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Shuling Yu, Jintao Yuan, Yi Zhang, Shufang Gao, Ying Gan, Meng Han, Yuewen Chen, Qiaoqiao Zhou, Jiahua Shi
AIM: Sodium-glucose cotransporter 2 (SGLT2) is a promising target for diabetes therapy. We aimed to develop computational approaches to identify structural features for more potential SGLT2 inhibitors. MATERIALS & METHODS: In this work, 46 triazole derivatives as SGLT2 inhibitors were studied using a combination of several approaches, including hologram quantitative structure-activity relationships (HQSAR), topomer comparative molecular field analysis (CoMFA), homology modeling, and molecular docking...
June 21, 2017: Future Medicinal Chemistry
Satyajit Maji, Maruthi M Brundavanam
A pair of stable noncanonical scalar vortices of the same charge is generated experimentally across the cross section of an optical beam using a computer-generated hologram with higher-order fractional screw dislocation. The noncanonical nature of the generated vortices is identified by the gradient of the phase around each vortex and also the crossing angle between the zero contours of the real and imaginary parts of the optical field. The anisotropy of the vortices is controlled by the fractional order of the computer-generated hologram...
June 15, 2017: Optics Letters
Tetsuhiko Muroi, Yutaro Katano, Nobuhiro Kinoshita, Norihiko Ishii
To increase the reproduced data transfer rate in holographic memory, we have investigated simultaneous reproduction of two data pages. By irradiating s- and p-polarization reference beams whose angle gap is equal to the angle between the neighboring data pages in angle-multiplexed holograms, two different data pages can simultaneously be reproduced with a bit error rate low enough to decode. This technology is effective to double the data transfer rate in holographic memory.
June 15, 2017: Optics Letters
Marcelle L F Bispo, Camilo H S Lima, Laura N F Cardoso, André L P Candéa, Flávio A F M Bezerra, Maria C S Lourenço, Maria G M O Henriques, Ricardo B Alencastro, Carlos R Kaiser, Marcus V N Souza, Magaly G Albuquerque
In an ongoing research program for the development of new anti-tuberculosis drugs, we synthesized three series (A, B, and C) of 7-chloro-4-aminoquinolines, which were evaluated in vitro against Mycobacterium tuberculosis (MTB). Now, we report the anti-MTB and cytotoxicity evaluations of a new series, D (D01-D21). Considering the active compounds of series A (A01-A13), B (B01-B13), C (C01-C07), and D (D01-D09), we compose a data set of 42 compounds and carried out hologram quantitative structure-activity relationship (HQSAR) analysis...
June 9, 2017: Pharmaceuticals
Ching-Han Yang, Andy Ying-Guey Fuh
In this study, we generate various complex beams carrying angular momentum (AM) by using a programmable beam shaping system to mimic typical q-plates. When a circularly polarized wave is incident onto the system, the emerging beam reverses its spin handedness and obtains a spatial phase factor. This phase factor can be engineered by designing a computer-generated hologram (CGH) and applying it to a spatial light modulator (SLM) to produce a beam with controllable spatially distributed orbital angular momentum (OAM) density...
June 5, 2017: Scientific Reports
Yu-Chih Lin, Chau-Jern Cheng, Li-Chien Lin
This study presents a time-resolved imaging technique for detecting ultrafast events in the sample with tunable tick-tock pulses in common-path digital holographic microscopy. The tick-tock pulses are generated from the same single femtosecond pulse source and manipulated through a spatial-multiplexing encoding/decoding scheme with two complementary binary codes for digital hologram recording and reconstruction. The spatial-multiplexing encoding/decoding scheme with compressive sensing on the Fresnel digital hologram is used to recover missing data and achieve high-fidelity wavefront reconstruction...
June 1, 2017: Optics Letters
Danielle Grolman, Diya Bandyopadhyay, Abdullah Al-Enizi, Ahmed Elzatahry, Alamgir Karim
Synthetic topographically patterned films and coatings are typically contoured on one side, yet many of nature's surfaces have distinct textures on different surfaces of the same object. Common examples are the top and bottom sides of the butterfly wing or lotus leaf, onion shells, and the inside versus outside of the stem of a flower. Inspired by nature, we create dual (top and bottom) channel patterned polymer films. To this end, we first develop a novel fabrication method to create ceramic line channel relief structures by converting the oligomeric residue of stamped poly(dimethylsiloxane) (PDMS) nanopatterns on silicon substrates to glass (SiOx, silica) by ultraviolet-ozone (UVO) exposure...
June 21, 2017: ACS Applied Materials & Interfaces
Vincenzo Grillo, Amir H Tavabi, Federico Venturi, Hugo Larocque, Roberto Balboni, Gian Carlo Gazzadi, Stefano Frabboni, Peng-Han Lu, Erfan Mafakheri, Frédéric Bouchard, Rafal E Dunin-Borkowski, Robert W Boyd, Martin P J Lavery, Miles J Padgett, Ebrahim Karimi
Electron waves that carry orbital angular momentum (OAM) are characterized by a quantized and unbounded magnetic dipole moment parallel to their propagation direction. When interacting with magnetic materials, the wavefunctions of such electrons are inherently modified. Such variations therefore motivate the need to analyse electron wavefunctions, especially their wavefronts, to obtain information regarding the material's structure. Here, we propose, design and demonstrate the performance of a device based on nanoscale holograms for measuring an electron's OAM components by spatially separating them...
May 24, 2017: Nature Communications
Philipp M Holl, Friedemann Reinhard
Wireless data transmission systems such as wi-fi or Bluetooth emit coherent light-electromagnetic waves with a precisely known amplitude and phase. Propagating in space, this radiation forms a hologram-a two-dimensional wave front encoding a three-dimensional view of all objects traversed by the light beam. Here we demonstrate a scheme to record this hologram in a phase-coherent fashion across a meter-sized imaging region. We recover three-dimensional views of objects and emitters by feeding the resulting data into digital reconstruction algorithms...
May 5, 2017: Physical Review Letters
Zengji Yue, Gaolei Xue, Juan Liu, Yongtian Wang, Min Gu
Holography has extremely extensive applications in conventional optical instruments spanning optical microscopy and imaging, three-dimensional displays and metrology. To integrate holography with modern low-dimensional electronic devices, holograms need to be thinned to a nanometric scale. However, to keep a pronounced phase shift modulation, the thickness of holograms has been generally limited to the optical wavelength scale, which hinders their integration with ultrathin electronic devices. Here, we break this limit and achieve 60 nm holograms using a topological insulator material...
May 18, 2017: Nature Communications
Ivani Pauli, Leonardo G Ferreira, Mariana L de Souza, Glaucius Oliva, Rafaela S Ferreira, Marco A Dessoy, Brian W Slafer, Luiz C Dias, Adriano D Andricopulo
AIM: Chagas disease is endemic in Latin America and no effective treatment is available. Efforts in drug research have focused on several enzymes from Trypanosoma cruzi, among which cruzain is a validated pharmacological target. METHODOLOGY: Chemometric analyses were performed on the data set using the hologram quantitative structure-activity relationship, comparative molecular field analysis and comparative molecular similarity index analysis methods. Docking simulations were executed using the crystallographic structure of cruzain in complex with a benzimidazole inhibitor...
May 2017: Future Medicinal Chemistry
Stephanie C Malek, Ho-Seok Ee, Ritesh Agarwal
We demonstrate reconfigurable phase-only computer-generated metasurface holograms with up to three image planes operating in the visible regime fabricated with gold nanorods on a stretchable polydimethylsiloxane substrate. Stretching the substrate enlarges the hologram image and changes the location of the image plane. Upon stretching, these devices can switch the displayed holographic image between multiple distinct images. This work opens up the possibilities for stretchable metasurface holograms as flat devices for dynamically reconfigurable optical communication and display...
June 14, 2017: Nano Letters
Kentaro Soma, Stan Konings, Ryotaro Aso, Naoto Kamiuchi, Genki Kobayashi, Hideto Yoshida, Seiji Takeda
An apparatus is developed for transmission electron microscopy (TEM) to acquire image and spectral data, such as TEM images, electron holograms, and electron energy loss spectra, synchronized with the measurement of the dynamic response of a specimen under an applied alternating current (AC) electric potential (voltage, denoted VAC). From a VAC of frequency f, a shutter pulse signal is generated to open and close a pre-specimen shutter in a base TEM apparatus. A pulse is generated per VAC cycle from the targeted phase Φ to Φ +∆Φ with phase width ∆Φ (∆Φ <2π)...
April 29, 2017: Ultramicroscopy
Longqing Cong, Prakash Pitchappa, Chengkuo Lee, Ranjan Singh
Controlling the phase of local radiation by using exotic metasurfaces has enabled promising applications in a diversified set of electromagnetic wave manipulation such as anomalous wavefront deflection, flat lenses, and holograms. Here, we theoretically and experimentally demonstrate an active phase transition in a micro-electromechanical system-based metadevice where both the phase response and the dispersion of the metamaterial cavity are dynamically tailored. The phase transition is determined by the radiative and the absorptive losses in a metal-insulator-metal cavity that obeys the coupled-mode theory...
May 4, 2017: Advanced Materials
Tatsuki Tahara, Yasuhiko Arai
We propose single-shot multiwavelength digital holography with an extremely large incident angle and show the digital recording of multiple object waves at multiple wavelengths with an angle of more than 40 degrees and no beam combiner to generate interference light. Both the avoidance of the crosstalk between the object waves at different wavelengths and the space-bandwidth extension are simultaneously achieved with a single-shot exposure of a monochromatic image sensor and a reference beam even when the wavelength difference between the object waves is small...
May 1, 2017: Applied Optics
Cesar G Tavera R, Manuel H De la Torre-I, Jorge M Flores-M, Ma Del Socorro Hernandez M, Fernando Mendoza-Santoyo, Manuel de J Briones-R, Jorge Sanchez-P
A bone's fracture could be produced by an excessive, repetitive, or sudden load. A regular medical practice to heal it is to fix it in two possible ways: external immobilization, using a ferule, or an internal fixation, using a prosthetic device commonly attached to the bone by means of surgical screws. The bone's volume loss due to this drilling modifies its structure either in the presence or absence of a fracture. To observe the bone's surface behavior caused by the drilling effects, a digital holographic interferometer is used to analyze the displacement surface's variations in nonfractured post-mortem porcine femoral bones...
May 1, 2017: Applied Optics
Hao Zhang, Liangcai Cao, Guofan Jin
We propose a layer-based algorithm with single-viewpoint rendering geometry to calculate a three-dimensional (3D) computer-generated hologram (CGH) with occlusion effect. The 3D scene is sliced into multiple parallel layers according to the depth information. Slab-based orthographic projection is implemented to generate shading information for each layer, which renders hidden primitives for occlusion processing. The layer-based angular spectrum with silhouette mask culling is used to calculate the wave propagations from the layers to the CGH plane without paraxial approximation...
May 1, 2017: Applied Optics
Zhenxiang Zeng, Huadong Zheng, Yingjie Yu, Anand K Asundi, Sergiy Valyukh
Among the important features of holographic displays are the wide viewing angles and the full color of the reconstructed images. The present work focuses on achievement of both features. We propose an increased-viewing-angle full-color holographic display using two tiled phase-only spatial light modulators (SLMs), a 4f concave mirrors system, and a temporal-spatial multiplexing method. The 4f optical system consists of two concave mirrors and serves to increase the viewing angle. A temporal-spatial multiplexing synchronization control (TSMSC) method is developed to achieve a full-color image and to remove the color crosstalk of the image...
May 1, 2017: Applied Optics
Tianlong Man, Yuhong Wan, Fan Wu, Dayong Wang
Fresnel incoherent correlation holography (FINCH) was proposed to break the barrier of spatial incoherent digital holographic imaging and show the potential of super-resolution imaging preferences. We developed FINCH as a compressive sensing modality and reconstruction procedure as an inverse problem in order to realize 3D tomographic imaging. Improved axial resolution is obtained via compressive reconstruction. Reconstruction guarantees and accuracy of the proposed method are discussed. Compared with the real-valued signal operation, the signal-to-noise ratio of the results is increased when reconstructing from the complex-valued hologram obtained from the FINCH system...
May 1, 2017: Applied Optics
Yuki Nagahama, Tomoyoshi Shimobaba, Takashi Kakue, Nobuyuki Masuda, Tomoyoshi Ito
A holographic projector utilizes holography techniques. However, there are several barriers to realizing holographic projections. One is deterioration of hologram image quality caused by speckle noise and ringing artifacts. The combination of the random phase-free method and the Gerchberg-Saxton (GS) algorithm has improved the image quality of holograms. However, the GS algorithm requires significant computation time. We propose faster methods for image quality improvement of random phase-free holograms using the characteristics of ringing artifacts...
May 1, 2017: Applied Optics
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