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Han-Byeol Kang, Tae-Youb Kim, Yong-Hae Kim, Seong-Mok Cho, Sanghoon Cheon, Chi-Young Hwang, Chi-Sun Hwang, Seung-Yeol Lee, Sung-Min Yoon
A phase modulation device was proposed for the implementation of hologram image for display applications. A Ge2Sb2Te5 (GST) film as thin as 7 nm was prepared between the ITO films to form the cavities corresponding a unit pixel. Nitrogen was incorporated into the GST for improving the thermal stability of the GST active region. The effects of the nitrogen doping on the physical properties of GST was investigated with the variations in doping amounts. The nitrogen incorporation was found to reduce the surface micro-roughness and to improve the thermal stability of the GST even after the crystallization by effectively suppressing the excessive grain growth...
September 1, 2018: Journal of Nanoscience and Nanotechnology
Taesik Go, Jun Ho Kim, Hyeokjun Byeon, Sang Joon Lee
Accurate and immediate diagnosis of malaria is important for medication of the infectious disease. Conventional methods for diagnosing malaria are time consuming and rely on the skill of experts. Therefore, an automatic and simple diagnostic modality is essential for healthcare in developing countries that lack the expertise of trained microscopists. In the present study, a new automatic sensing method using digital in-line holographic microscopy (DIHM) combined with machine learning algorithms was proposed to sensitively detect unstained malaria-infected red blood cells (RBCs)...
April 19, 2018: Journal of Biophotonics
Junsheng Wang, Xiaomei Yu, Yanjuan Wang, Xinxiang Pan, Dongqing Li
A rapid detection of micro-algae activity is critical for analysis of ship ballast water. A new method for detecting micro-algae activity based on lens-free optofluidic holographic imaging is presented in this paper. A compact lens-free optofluidic holographic imaging device was developed. This device is mainly composed of a light source, a small through-hole, a light propagation module, a microfluidic chip, and an image acquisition and processing module. The excited light from the light source passes through a small hole to reach the surface of the micro-algae cells in the microfluidic chip, and a holographic image is formed by the diffraction light of surface of micro-algae cells...
March 2018: Biomicrofluidics
Teruyoshi Nobukawa, Tetsuhiko Muroi, Yutaro Katano, Nobuhiro Kinoshita, Norihiko Ishii
Single-shot phase-shifting incoherent digital holography with multiplexed checkerboard phase gratings is proposed for acquiring holograms of moving objects. The gratings presented here play the following three roles: dividing the beams, modulating the curvature of spherical beams, and introducing different phase shifts. With the gratings of our proposed method, four individual holograms of a spatially incoherent light are formed on an image sensor. Therefore, it is possible to simultaneously capture four holograms and implement a phase-shifting technique...
April 15, 2018: Optics Letters
Manon Rostykus, Mattia Rossi, Christophe Moser
We report on a method to increase the spatial resolution in a compact lensless microscope. A compact side illumination is fabricated to illuminate the sample with a collimated beam by diffraction from a volume phase grating. The wavelength of a semi-conductor laser source (vertical-cavity surface-emitting laser) is tuned with the injection current to alter the illumination direction by wavelength selective diffraction from the volume phase grating. The angle tuning is such that several subpixel shifted digital inline holograms are obtained...
April 15, 2018: Optics Letters
Fereshteh Shiri, Maryam Salahinejad, Rahmatollah Dijoor, Massoud Nejati-Yazdinejad
Pathogenic Gram-negative bacteria are responsible for nearly half of the serious human infections. Hologram quantitative structure-activity relationships (HQSAR), comparative molecular field analysis (CoMFA), and comparative molecular similarity index analysis (CoMSIA) were implemented on a group of 32 of potent Gram-negative LpxC inhibitors. The most effective HQSAR model was obtained using atoms, bonds, donor, and acceptor as fragment distinction. The cross-validated correlation coefficient (q2 ), non-cross-validated correlation coefficient (r2 ), and predictive correlation coefficient (r2 Pred ) for test set of HQSAR model were 0...
April 6, 2018: Journal of Receptor and Signal Transduction Research
Jianbo Tong, Pei Zhan, Xiang Simon Wang, Yingji Wu
Quionolone carboxylic acid derivatives as inhibitors of HIV-1 integrase were investigated as a potential class of drugs for the treatment of acquired immunodeficiency syndrome (AIDS). Hologram quantitative structure-activity relationships (HQSAR) and translocation comparative molecular field vector analysis (topomer CoMFA) were applied to a series of 48 quionolone carboxylic acid derivatives. The most effective HQSAR model was obtained using atoms and bonds as fragment distinctions: cross-validation q 2 = 0...
December 2017: Journal of Chemometrics
Colton M Bigler, Pierre-Alexandre Blanche, Kalluri Sarma
The field of view of traditional heads-up display systems is limited by the size of the projection optics. Our research is focused on overcoming this limitation by coupling image-bearing light into a waveguide using holographic elements, propagating the light through that waveguide, and extracting the light several times with additional holographic optical elements. With this configuration, we demonstrated both longitudinal magnification and pupil expansion of the heads-up display. We created a ray-trace model of the optical system to optimize the component parameters and implemented the solution in a prototype that demonstrates the merit of our approach...
March 20, 2018: Applied Optics
Daniel L Marks, David R Smith
Multiplex volume holograms are conventionally constructed by the repeated exposure of a photosensitive medium to a sequence of external fields, each field typically being the superposition of a reference wave that reconstructs the hologram and the other being a desired signal wave. Because there are no sources of radiation internal to the hologram, the pattern of material modulation is limited to the solutions to Helmholtz's equation in the medium. If the three-dimensional structure of the medium could be engineered at each point rather than limited to the patterns produced by standing waves, more versatile structures may result that can overcome the typical limitations to hologram dynamic range imposed by sequentially superimposing holograms...
April 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Zi-Lan Deng, Junhong Deng, Xin Zhuang, Shuai Wang, Kingfai Li, Yao Wang, Yihui Chi, Xuan Ye, Jian Xu, Guo Ping Wang, Rongkuo Zhao, Xiaolei Wang, Yaoyu Cao, Xing Cheng, Guixin Li, Xiangping Li
The emerging metasurfaces with the exceptional capability of manipulating an arbitrary wavefront have revived the holography with unprecedented prospects. However, most of the reported meta-holograms suffer from limited polarization controls for a restrained bandwidth, in addition to their complicated meta-atom designs with spatially-variant dimensions. Here, we demonstrate a new concept of vectorial holography based on diatomic metasurfaces consisting of meta-molecules formed by two orthogonal meta-atoms. Based on a simply linear relationship between phase and polarization modulations with displacements and orientations of identical meta-atoms, active diffraction of multiple polarization states and reconstruction of holographic images are simultaneously achieved, which is robust against both incident angles and wavelengths...
March 28, 2018: Nano Letters
Yuqian Li, Bruno Cornelis, Alexandra Dusa, Geert Vanmeerbeeck, Dries Vercruysse, Erik Sohn, Kamil Blaszkiewicz, Dimiter Prodanov, Peter Schelkens, Liesbet Lagae
Three-part white blood cell differentials which are key to routine blood workups are typically performed in centralized laboratories on conventional hematology analyzers operated by highly trained staff. With the trend of developing miniaturized blood analysis tool for point-of-need in order to accelerate turnaround times and move routine blood testing away from centralized facilities on the rise, our group has developed a highly miniaturized holographic imaging system for generating lens-free images of white blood cells in suspension...
March 14, 2018: Computers in Biology and Medicine
Ghazaleh Kafaie Shirmanesh, Ruzan Sokhoyan, Ragip A Pala, Harry A Atwater
Active metasurfaces composed of electrically reconfigurable nanoscale subwavelength antenna arrays can enable real-time control of scattered light amplitude and phase. Achievement of widely tunable phase and amplitude in chip-based active metasurfaces operating at or near 1550 nm wavelength have considerable potential for active beam steering, dynamic hologram rendition, and realization of flat optics with reconfigurable focal lengths. Previously, electrically tunable conducting oxide-based reflectarray metasurfaces have demonstrated dynamic phase control of reflected light with a maximum phase shift of 184° (Nano Lett...
March 23, 2018: Nano Letters
S A Amin, N Adhikari, S Bhargava, T Jha, S Gayen
The current study deals with chemometric modelling strategies (Naïve Bayes classification, hologram-based quantitative structure-activity relationship (HQSAR), comparative molecular field analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA)) to explore the important features of hydroxylamine derivatives for exerting potent human immunodeficiency virus-1 (HIV-1) protease inhibition. Depending on the statistically validated reliable and robust quantitative structure-activity relationship (QSAR) models, important and crucial structural features have been identified that may be responsible for enhancing the activity profile of these hydroxylamine compounds...
March 23, 2018: SAR and QSAR in Environmental Research
Jannis Köhler, Jegor Ruschke, Katja Bettina Ferenz, Cemal Esen, Michael Kirsch, Andreas Ostendorf
Albumin-derived perfluorocarbon-based capsules are promising as artificial oxygen carriers with high solubility. However, these capsules have to be studied further to allow initial human clinical tests. The aim of this paper is to provide and characterize a holographic optical tweezer to enable contactless trapping and moving of individual capsules in an environment that mimics physiological (in vivo) conditions most effectively in order to learn more about the artificial oxygen carrier behavior in blood plasma without recourse to animal experiments...
February 1, 2018: Biomedical Optics Express
Jose Luis Martínez Fuentes, Ignacio Moreno
A new technique for encoding the amplitude and phase of diffracted fields in digital holography is proposed. It is based on a random spatial multiplexing of two phase-only diffractive patterns. The first one is the phase information of the intended pattern, while the second one is a diverging optical element whose purpose is the control of the amplitude. A random number determines the choice between these two diffractive patterns at each pixel, and the amplitude information of the desired field governs its discrimination threshold...
March 5, 2018: Optics Express
Jani Mäkinen, Erdem Sahin, Atanas Gotchev
We propose a speckle noise reduction method for generation of coherent holographic stereograms. The method employs densely sampled light field (DSLF) of the scene together with depth information acquired for each ray in the captured DSLF. Speckle reduction is achieved based on the ray separation technique where the scene is first described as a superposition of sparse sets of point sources corresponding to separated sets of rays and then the holographic reconstructions corresponding to these sparse sets of point sources are added incoherently (intensity-wise) to obtain the final reconstruction...
March 5, 2018: Optics Express
Okan Yurduseven, Daniel L Marks, Thomas Fromenteze, David R Smith
We present a reconfigurable, dynamic beam steering holographic metasurface aperture to synthesize a microwave camera at K-band frequencies. The aperture consists of a 1D printed microstrip transmission line with the front surface patterned into an array of slot-shaped subwavelength metamaterial elements (or meta-elements) dynamically tuned between "ON" and "OFF" states using PIN diodes. The proposed aperture synthesizes a desired radiation pattern by converting the waveguide-mode to a free space radiation by means of a binary modulation scheme...
March 5, 2018: Optics Express
Muhammed Veli, Aydogan Ozcan
We present a cost-effective and portable platform based on contact lenses for non-invasively detecting Staphylococcus aureus, which is part of the human ocular microbiome and resides on the cornea and conjunctiva. Using Staphylococcus aureus-specific antibodies and a surface chemistry protocol that is compatible with human tear, contact lenses are designed to specifically capture Staphylococcus aureus. After the bacteria capture on the lens, and right before its imaging, the captured bacteria are tagged with surface-functionalized polystyrene microparticles...
March 9, 2018: ACS Nano
Hamid Salvdari, M Taghi Tavassoly
Fresnel diffraction from the edge of a transparent plate with arbitrary orientation of its surfaces is formulated in transmission mode. It is shown theoretically and evaluated experimentally that the thickness of a plate and the angles between its surfaces, near the edge, can be determined accurately. This allows us to construct a quantitative 3D image of the plate edge. It is also illustrated that the recorded diffraction pattern of a plate edge can be regarded as a hologram produced by the interference of two diffracted waves: one passing above the plate and the other transmitting through the plate near the edge...
March 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Timothy O'Connor, Siddharth Rawat, Adam Markman, Bahram Javidi
We propose a compact imaging system that integrates an augmented reality head mounted device with digital holographic microscopy for automated cell identification and visualization. A shearing interferometer is used to produce holograms of biological cells, which are recorded using customized smart glasses containing an external camera. After image acquisition, segmentation is performed to isolate regions of interest containing biological cells in the field-of-view, followed by digital reconstruction of the cells, which is used to generate a three-dimensional (3D) pseudocolor optical path length profile...
March 1, 2018: Applied Optics
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