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Kana Takahashi, Madoka Morota, Yoshikazu Kagami, Hiroyuki Okamoto, Shuhei Sekii, Koji Inaba, Naoya Murakami, Hiroshi Igaki, Yoshinori Ito, Takashi Uno, Jun Itami
BACKGROUND: This prospective study aimed to compare dose volume histograms (DVH) of the breasts and organs at risk (OARs) of whole breast radiotherapy in the supine and prone positions, and frequency and severity of acute and late toxicities were analyzed. METHODS: Early-stage breast cancer patients with large breasts (Japanese bra size C or larger, or the widest measurements of the bust ≥ 95 cm) undergoing partial mastectomy participated in this study. CT-based treatment plans were made in each position, and various dosimetric parameters for the breast and OARs were calculated to compare the supine and prone radiotherapy plans...
September 29, 2016: BMC Cancer
Michio Yoshida, Eriko Kajikawa, Daisuke Yamamoto, Daisuke Kurokawa, Shigenobu Yonemura, Kensaku Kobayashi, Hiroshi Kiyonari, Shinichi Aizawa
BACKGROUND: Previous comparative studies suggest that the requirement for Nodal in epiblast and hypoblast development is unique to mammalians. Expression of anterior visceral endoderm (AVE) genes in the visceral endoderm and of their orthologs in the hypoblast may be unique to mammalians and avians, and is absent in the reptilian hypoblast. Axis formation in reptiles is signaled by the formation of the posterior marginal epiblast (PME), which expresses a series of primitive streak genes...
September 26, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
Camila Fernandes Pollo Maranzatto, Hélio Amante Miot, Luciane Donida Bartoli Miot, Silmara Meneguin
BACKGROUND: Although asymptomatic, melasma inflicts significant impact on quality of life. MELASQoL is the main instrument used to assess quality of life associated with melasma, it has been validated in several languages, but its latent dimensional structure and psychometric properties haven´t been fully explored. OBJECTIVES: To evaluate psychometric characteristics, information and dimensional structure of the Brazilian version of MELASQoL. METHODS: Survey with patients with facial melasma through socio-demographic questionnaire, DLQI-BRA, MASI and MELASQoL-BP, exploratory and confirmatory factor analysis, internal consistency of MELASQoL and latent dimensions (Cronbach's alpha)...
July 2016: Anais Brasileiros de Dermatologia
(no author information available yet)
While 40% of women feel breast pain while riding, fewer than 20% wear a sports bra.
August 31, 2016: Nursing Standard
Zhenggang Zhang, Michael Chopp
Stroke activates neural stem cells in the ventricular-subventricular zone (V/SVZ) of the lateral ventricle, which increases neuroblasts and oligodendrocyte progenitor cells (OPCs). Within the ischemic brain, neural stem cells, neuroblasts and OPCs appear to actively communicate with cerebral endothelial cells and other brain parenchymal cells to mediate ischemic brain repair; however, stroke-induced neurogenesis unlikely plays any significant roles in neuronal replacement. In this mini-review, we will discuss recent findings how intercellular communications between stroke-induced neurogenesis and oligodendrogenesis and brain parenchymal cells could potentially facilitate brain repair processes...
September 2016: Journal of Stroke
Jenny Burbage, Lorna Cameron
For female horse riders, breast pain, bra issues and breast size may be important concerns which have yet to be considered. This study aimed to establish the prevalence of breast pain and bra issues in female horse riders and explores the impact of breast size on breast pain and bra issues. A 6-part, 32 question online survey was completed by 1324 females who participated in horse riding activities. Descriptive and chi-squared (χ(2)) analyses were utilised; data for 1265 participants were included in the final analysis...
July 25, 2016: Journal of Sports Sciences
Elthon G Ferreira, Maria da Conceição M Torres, Alison B da Silva, Larissa L F Colares, Karine Pires, Tito M C Lotufo, Edilberto R Silveira, Otília D L Pessoa, Leticia V Costa-Lotufo, Paula C Jimenez
Saint Peter and Saint Paul's Archipelago is a collection of 15 islets and rocks remotely located in the equatorial Atlantic Ocean. In this particular site, the present project intended to assess the biodiversity and biotechnological potential of bacteria from the actinomycete group. This study presents the first results of this assessment. From 21 sediment samples, 268 strains were isolated and codified as BRA followed by three numbers. Of those, 94 strains were grown in liquid media and submitted to chemical extractions with AcOEt (A), BuOH (B), and MeOH (M)...
September 2016: Chemistry & Biodiversity
Luciano S de Lima, Eric Martineau, Francilaine E De Marchi, Marie-France Palin, Geraldo T Dos Santos, Hélène V Petit
The objective of this study was to develop a technique for carrying out repeated biopsies of the mammary gland of lactating dairy cows that provides enough material to monitor enzyme activities and gene expression in mammary secretory tissue. A total of 16 Holstein cows were subjected to 4 mammary biopsies each at 3-week intervals for a total of 64 biopsies. A 0.75-cm incision was made through the skin and subcutaneous tissue of the mammary gland and a trocar and cannula were inserted using a circular motion...
July 2016: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
Otavio Tavares Ranzani, Daniel Neves Forte, Antonio Carlos Forte, Igor Mimica, Wilma Carvalho Neves Forte
Objective: Ventilator-associated pneumonia (VAP) is the leading type of hospital-acquired infection in ICU patients. The diagnosis of VAP is challenging, mostly due to limitations of the diagnostic methods available. The aim of this study was to determine whether antibody-coated bacteria (ACB) evaluation can improve the specificity of endotracheal aspirate (EA) culture in VAP diagnosis. Methods: We conducted a diagnostic case-control study, enrolling 45 patients undergoing mechanical ventilation...
May 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Ji-Hye Byun, Sun-Hong Kwon, Ji-Hye Ha, Eui-Kyung Lee
PURPOSE: The benefit-risk balance for drugs can alter post approval owing to additional data on efficacy or adverse events. This study developed a quantitative benefit-risk assessment (BRA) model for statins using multicriteria decision analysis with discrete choice experiments and compared a recent BRA with that at the time of approval. PATIENTS AND METHODS: Following a systematic review of the literature, the benefit criteria within the statin BRA model were defined as a reduction in the plasma low-density lipoprotein cholesterol level and a reduction in myocardial infarction incidence; the risk criteria were hepatotoxicity (Liv) and fatal rhabdomyolysis (Rha)...
2016: Therapeutics and Clinical Risk Management
María Victoria Vieiro Medina, Ramón Gómez Sanz, Eneida Bra Insa, Iván Domínguez Sánchez, Marta de la Fuente Bartolomé, David Díaz Pérez, Oana Anisa Nutu, Felipe de la Cruz Vigo
We present the case of a 69 year old woman with a history of cholecystitis, who consulted for severe abdominal pain, nausea and vomiting. Abdominal CT showed duodenal obstruction caused by a gallstone, cholecystoduodenal fistula and pneumobilia, what is known as Bouveret's syndrome, a rare form of gallstone ileus. Additionally, she presented free duodenal and vesicular perforation to retroperitoneum at the same level of the cholecystoduodenal transit point. The patient underwent a difficult cholecystectomy, enterolithotomy, repair of the duodenal defect, extensive washing and drainage of the retroperitoneum...
June 2016: Revista Española de Enfermedades Digestivas
Kashyap Komarraju Tadisina, Gianfranco Frojo, Christina M Plikaitis, Michael L Bernstein
No abstract text is available yet for this article.
October 2016: Plastic and Reconstructive Surgery
Virgílio Gavicho Uarrota, Eduardo da Costa Nunes, Luiz Augusto Martins Peruch, Enilto de Oliveira Neubert, Bianca Coelho, Rodolfo Moresco, Moralba Garcia Domínguez, Teresa Sánchez, Jorge Luis Luna Meléndez, Dominique Dufour, Hernan Ceballos, Luis Augusto Becerra Lopez-Lavalle, Clair Hershey, Miguel Rocha, Marcelo Maraschin
Food losses can occur during production, postharvest, and processing stages in the supply chain. With the onset of worldwide food shortages, interest in reducing postharvest losses in cassava has been increasing. In this research, the main goal was to evaluate biochemical changes and identify the metabolites involved in the deterioration of cassava roots. We found that high levels of ascorbic acid (AsA), polyphenol oxidase (PPO), dry matter, and proteins are correlated with overall lower rates of deterioration...
May 2016: Food Science & Nutrition
Kentaro Tanaka, Kazuto Takada, Eiji Kojima, Takahiro Shimizu, Shohko Miyamatsu, Kango Nohara, Tsutomu Sakurai, Takaaki Mizuno, Yuuki Yamashita
A 69-year-old man visited a clinic for left leg weakness. With suspicions of lung cancer and a metastatic brain tumor, he was referred to our hospital and was diagnosed with large cell neuroendocrine carcinoma, cT1bN0M1b (BRA), stage IV. After stereotactic radiosurgery for his brain metastasis, he was treated with chemotherapy containing cisplatin and irinotecan. A week after initiating chemotherapy, he suddenly developed severe right leg pain and adynamia. A computed tomography angiogram revealed occlusion of the right common femoral artery, and percutaneous thrombectomy was performed...
May 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Lorenzo Ricci, Fabien Cabrera, Sonia Lotito, Stefano Tiozzo
In all non-vertebrate metazoan phyla, species that evolved non-embryonic developmental pathways as means of propagation or regeneration can be found. In this context, new bodies arise through asexual reproduction processes (such as budding) or whole body regeneration, that lack the familiar temporal and spatial cues classically associated with embryogenesis, like maternal determinants, or gastrulation. The molecular mechanisms underlying those non-embryonic developments (i.e., regeneration and asexual reproduction), and their relationship to those deployed during embryogenesis are poorly understood...
August 1, 2016: Developmental Biology
Kenneth K Hansraj
OBJECTIVE: It is a well-established fact that women who have large, heavy breasts suffer from spine pain. The objective of this study is to assess the forces that the breast exerts on the spine. It is important that such women understand the stresses that the spine is forced to sustain because of heavy breasts. MATERIALS AND METHODS: The study was conducted using finite element analyses (FEA) of a human spine under different loads, loads being defined as incremental weights being sustained by the spine...
April 2016: Surgical Technology International
Emma K Farley, Katrina M Olson, Wei Zhang, Daniel S Rokhsar, Michael S Levine
Transcriptional enhancers are short segments of DNA that switch genes on and off in response to a variety of intrinsic and extrinsic signals. Despite the discovery of the first enhancer more than 30 y ago, the relationship between primary DNA sequence and enhancer activity remains obscure. In particular, the importance of "syntax" (the order, orientation, and spacing of binding sites) is unclear. A high-throughput screen identified synthetic notochord enhancers that are activated by the combination of ZicL and ETS transcription factors in Ciona embryos...
June 7, 2016: Proceedings of the National Academy of Sciences of the United States of America
Charles W Heaps, David A Mazziotti
Trajectory-based Gaussian basis sets have been tremendously successful in describing high-dimensional quantum molecular dynamics. In this paper, we introduce a pseudospectral Gaussian-based method that achieves accurate quantum dynamics using efficient, real-space sampling of the time-dependent basis set. As in other Gaussian basis methods, we begin with a basis set expansion using time-dependent Gaussian basis functions guided by classical mechanics. Unlike other Gaussian methods but characteristic of the pseudospectral and collocation methods, the basis set is tested with N Dirac delta functions, where N is the number of basis functions, rather than using the basis function as test functions...
April 28, 2016: Journal of Chemical Physics
Celeste E Coltman, Deirdre E McGhee, Julie R Steele
BACKGROUND: This study aimed to compare breast volume calculated from scanning large ptotic breasts of women while they were standing upright relative to when lying prone in order to identify the error associated with breast volume calculations Methods: Breast volume and visualization were compared in 50 women with large breasts (D(+) bra cup size) while they were scanned in three different positions. RESULTS: Full visualization of both breasts occurred in 100% of participants in the prone position and only 5% of participants in either standing position...
April 12, 2016: Ergonomics
Kai Yang, Qiu-ping Su, Qi-zhong Qin, Bai-jie Tu
OBJECTIVE: To investigate the neurotoxic effect of benzo[α]pryene (B[α]P) and protective effect of butylated hydroxyl anisole (BHA) on learning and memory in hippocampus of rats. METHODS: Ninety male, SD rats were randomly divided into blank control group, solvent control group, B[α]P exposed group [(2 mg/(kg x d)], BRA group [50 mg/(kg x d)] and B[α]P + BHA combined group. Rats were given the appropriate dose oral treatment according to body mass and group (the same volume of saline and peanut oil were given to blank and solvent control group, respectively) for 90 d...
January 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
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