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K13 propeller

Sandie Menard, Joëlle Njila Tchoufack, Christelle Ngou Maffo, Sandrine E Nsango, Xavier Iriart, Luc Abate, Majoline Tchioffo Tsapi, Parfait H Awono-Ambéné, Francis A Abega Mekongo, Isabelle Morlais, Antoine Berry
BACKGROUND: The spread of Plasmodium falciparum resistance to artemisinin derivatives in Southeast Asia is a major source of concern and the emergence of resistance in Africa would have dramatic consequences, by increasing malaria mortality and morbidity. It is therefore urgent to implement regular monitoring in sentinel sites in sub-Saharan Africa using robust and easy-to-implement tools. The prevalence of k13-propeller mutations and the phenotypic profiles are poorly known in sub-Saharan Africa...
November 26, 2016: Malaria Journal
Mónica Guerra, Rita Neres, Patrícia Salgueiro, Cristina Mendes, Nicolas Ndong-Mabale, Pedro Berzosa, Bruno de Sousa, Ana Paula Arez
The efforts to control malaria may affect malaria parasite genetic variability and drug resistance, the latter associated with genetic events that promote mechanisms to escape drug action. The worldwide spread of drug resistance has been a major obstacle in controlling Plasmodium falciparum malaria, thus the study of the origin and spread of associated mutations may provide some insights in the prevention of its emergence.This study reports the analysis of P. falciparum genetic diversity focusing antimalarial resistance associated molecular markers in two socioeconomically different villages in mainland Equatorial Guinea...
October 24, 2016: Antimicrobial Agents and Chemotherapy
Eric P M Grist, Jennifer A Flegg, Georgina Humphreys, Ignacio Suay Mas, Tim J C Anderson, Elizabeth A Ashley, Nicholas P J Day, Mehul Dhorda, Arjen M Dondorp, M Abul Faiz, Peter W Gething, Tran T Hien, Tin M Hlaing, Mallika Imwong, Jean-Marie Kindermans, Richard J Maude, Mayfong Mayxay, Marina McDew-White, Didier Menard, Shalini Nair, Francois Nosten, Paul N Newton, Ric N Price, Sasithon Pukrittayakamee, Shannon Takala-Harrison, Frank Smithuis, Nhien T Nguyen, Kyaw M Tun, Nicholas J White, Benoit Witkowski, Charles J Woodrow, Rick M Fairhurst, Carol Hopkins Sibley, Philippe J Guerin
BACKGROUND: Artemisinin-resistant Plasmodium falciparum malaria parasites are now present across much of mainland Southeast Asia, where ongoing surveys are measuring and mapping their spatial distribution. These efforts require substantial resources. Here we propose a generic 'smart surveillance' methodology to identify optimal candidate sites for future sampling and thus map the distribution of artemisinin resistance most efficiently. METHODS: The approach uses the 'uncertainty' map generated iteratively by a geostatistical model to determine optimal locations for subsequent sampling...
October 24, 2016: International Journal of Health Geographics
Praveen K Bharti, Man M Shukla, Pascal Ringwald, Sri Krishna, Pushpendra P Singh, Ajay Yadav, Sweta Mishra, Usha Gahlot, Jai P Malaiya, Amit Kumar, Shambhu Prasad, Pradeep Baghel, Mohan Singh, Jaiprakash Vadadi, Mrigendra P Singh, Maria Dorina G Bustos, Leonard I Ortega, Eva-Maria Christophel, Sher S Kashyotia, Gagan S Sonal, Neeru Singh
BACKGROUND: Anti-malarial drug resistance continues to be a leading threat to malaria control efforts and calls for continued monitoring of waning efficacy of artemisinin-based combination therapy (ACT). Artesunate + sulfadoxine/pyrimethamine (AS + SP) is used for the treatment of uncomplicated Plasmodium falciparum malaria in India. However, resistance against AS + SP is emerged in northeastern states. Therefore, artemether-lumefantrine (AL) is the recommended first line treatment for falciparum malaria in north eastern states...
October 13, 2016: Malaria Journal
Jean Baptiste Roseau, Bruno Pradines, Nicolas Paleiron, Serge Vedy, Marylin Madamet, Fabrice Simon, Emilie Javelle
BACKGROUND: Artemisinin-based combination therapy (ACT) introduced in the mid-1990s has been recommended since 2005 by the World Health Organization as first-line treatment against Plasmodium falciparum in all endemic countries. In 2010, the combination dihydroartemisinin-piperaquine (DP) was recommended for the treatment of uncomplicated P. falciparum malaria. DP is one of the first-line treatments used by the French army since 2013. CASE PRESENTATION: A case of P...
2016: Malaria Journal
Grégoire Falq, Rafael Van Den Bergh, Martin De Smet, William Etienne, Chea Nguon, Huy Rekol, Mallika Imwong, Arjen Dondorp, Jean-Marie Kindermans
BACKGROUND: In Cambodia, elimination of artemisinin resistance through direct elimination of the Plasmodium falciparum parasite may be the only strategy. Prevalence and incidence at district and village levels were assessed in Chey Saen district, Preah Vihear province, North of Cambodia. Molecular and clinical indicators for artemisinin resistance were documented. METHODS: A cross sectional prevalence survey was conducted at village level in the district of Chey Saen from September to October 2014...
2016: Malaria Journal
Costanza Tacoli, Prabhanjan P Gai, Claude Bayingana, Kevin Sifft, Dominik Geus, Jules Ndoli, Augustin Sendegeya, Jean Bosco Gahutu, Frank P Mockenhaupt
Emerging artemisinin resistance is a threat to global malaria control. Mutations in the Plasmodium falciparum Kelch 13 (K13) propeller domain confer artemisinin resistance and constitute molecular markers for its detection and monitoring. We sequenced 222 P. falciparum isolates obtained from community children in the Huye District of southern Rwanda in 2010, 2014, and 2015 to investigate the presence of K13 polymorphisms. No polymorphisms were observed in 2010 but they were present in 2.5% and 4.5% in 2014 and 2015, respectively...
November 2, 2016: American Journal of Tropical Medicine and Hygiene
Moses Ocan, Freddie Bwanga, Alfred Okeng, Fred Katabazi, Edgar Kigozi, Samuel Kyobe, Jasper Ogwal-Okeng, Celestino Obua
BACKGROUND: In the absence of an effective vaccine, malaria treatment and eradication is still a challenge in most endemic areas globally. This is especially the case with the current reported emergence of resistance to artemisinin agents in Southeast Asia. This study therefore explored the prevalence of K13-propeller gene polymorphisms among Plasmodium falciparum parasites in northern Uganda. METHODS: Adult patients (≥18 years) presenting to out-patients department of Lira and Gulu regional referral hospitals in northern Uganda were randomly recruited...
2016: BMC Infectious Diseases
Aurore Ogouyèmi-Hounto, Georgia Damien, Awa Bineta Deme, Nicaise T Ndam, Constance Assohou, Didier Tchonlin, Atika Mama, Virgile Olivier Hounkpe, Jules Doumitou Moutouama, Franck Remoué, Daouda Ndiaye, Dorothée Kinde Gazard
AIM: In Benin, artemisinin-based combination therapy (ACT) has been recommended as the first-line treatment for uncomplicated Plasmodium falciparum malaria since 2004. The emergence in Southeast Asia of parasites that are resistant to artemisinins poses a serious threat to global control of this disease. The presence of artemisinin resistance genotypes in parasite populations in Benin is currently unknown. The present study investigated the prevalence of relevant K13-propeller gene polymorphisms in parasite isolates from the north-western region of Benin...
2016: Parasite: Journal de la Société Française de Parasitologie
Lina M Q Alareqi, Mohammed A K Mahdy, Yee-Ling Lau, Mun-Yik Fong, Rashad Abdul-Ghani, Rohela Mahmud
Since 2005, artesunate (AS) plus sulfadoxine/pyrimethamine (SP) combination has been adopted as the first-line treatment for uncomplicated malaria in Yemen in response to the high level of Plasmodium falciparum resistance to chloroquine (CQ). Therefore, the aim of the present study was to determine the frequency distribution of molecular markers associated with resistance to CQ and AS plus SP combination among P. falciparum isolates from a malaria-endemic area in Taiz governorate, Yemen. Fifty P. falciparum isolates were collected during a cross-sectional study in Mawza district, Taiz, in the period from October 2013 to April 2014...
October 2016: Acta Tropica
Améyo M Dorkenoo, Degninou Yehadji, Yao M Agbo, Yao Layibo, Foli Agbeko, Poukpessi Adjeloh, Kossi Yakpa, Efoe Sossou, Fantchè Awokou, Pascal Ringwald
BACKGROUND: Since 2005, the Togo National Malaria Control Programme has recommended two different formulations of artemisinin-based combination therapy (ACT), artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL), for the treatment of uncomplicated malaria. Regular efficacy monitoring of these two combinations is conducted every 2 or 3 years. This paper reports the latest efficacy assessment results and the investigation of mutations in the k13 propeller domain. METHODS: The study was conducted in 2012-2013 on three sentinel sites of Togo (Lomé, Sokodé and Niamtougou)...
June 22, 2016: Malaria Journal
Johanna P Daily
No abstract text is available yet for this article.
June 23, 2016: New England Journal of Medicine
Didier Ménard, Nimol Khim, Johann Beghain, Ayola A Adegnika, Mohammad Shafiul-Alam, Olukemi Amodu, Ghulam Rahim-Awab, Céline Barnadas, Antoine Berry, Yap Boum, Maria D Bustos, Jun Cao, Jun-Hu Chen, Louis Collet, Liwang Cui, Garib-Das Thakur, Alioune Dieye, Djibrine Djallé, Monique A Dorkenoo, Carole E Eboumbou-Moukoko, Fe-Esperanza-Caridad J Espino, Thierry Fandeur, Maria-Fatima Ferreira-da-Cruz, Abebe A Fola, Hans-Peter Fuehrer, Abdillahi M Hassan, Socrates Herrera, Bouasy Hongvanthong, Sandrine Houzé, Maman L Ibrahim, Mohammad Jahirul-Karim, Lubin Jiang, Shigeyuki Kano, Wasif Ali-Khan, Maniphone Khanthavong, Peter G Kremsner, Marcus Lacerda, Rithea Leang, Mindy Leelawong, Mei Li, Khin Lin, Jean-Baptiste Mazarati, Sandie Ménard, Isabelle Morlais, Hypolite Muhindo-Mavoko, Lise Musset, Kesara Na-Bangchang, Michael Nambozi, Karamoko Niaré, Harald Noedl, Jean-Bosco Ouédraogo, Dylan R Pillai, Bruno Pradines, Bui Quang-Phuc, Michael Ramharter, Milijaona Randrianarivelojosia, Jetsumon Sattabongkot, Abdiqani Sheikh-Omar, Kigbafori D Silué, Sodiomon B Sirima, Colin Sutherland, Din Syafruddin, Rachida Tahar, Lin-Hua Tang, Offianan A Touré, Patrick Tshibangu-wa-Tshibangu, Inès Vigan-Womas, Marian Warsame, Lyndes Wini, Sedigheh Zakeri, Saorin Kim, Rotha Eam, Laura Berne, Chanra Khean, Sophy Chy, Malen Ken, Kaknika Loch, Lydie Canier, Valentine Duru, Eric Legrand, Jean-Christophe Barale, Barbara Stokes, Judith Straimer, Benoit Witkowski, David A Fidock, Christophe Rogier, Pascal Ringwald, Frederic Ariey, Odile Mercereau-Puijalon
BACKGROUND: Recent gains in reducing the global burden of malaria are threatened by the emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations in portions of a P. falciparum gene encoding kelch (K13)-propeller domains are the major determinant of resistance has provided opportunities for monitoring such resistance on a global scale. METHODS: We analyzed the K13-propeller sequence polymorphism in 14,037 samples collected in 59 countries in which malaria is endemic...
June 23, 2016: New England Journal of Medicine
Aung Pyae Phyo, Elizabeth A Ashley, Tim J C Anderson, Zbynek Bozdech, Verena I Carrara, Kanlaya Sriprawat, Shalini Nair, Marina McDew White, Jerzy Dziekan, Clare Ling, Stephane Proux, Kamonchanok Konghahong, Atthanee Jeeyapant, Charles J Woodrow, Mallika Imwong, Rose McGready, Khin Maung Lwin, Nicholas P J Day, Nicholas J White, Francois Nosten
BACKGROUND: Deployment of mefloquine-artesunate (MAS3) on the Thailand-Myanmar border has led to a sustained reduction in falciparum malaria, although antimalarial efficacy has declined substantially in recent years. The role of Plasmodium falciparum K13 mutations (a marker of artemisinin resistance) in reducing treatment efficacy remains controversial. METHODS: Between 2003 and 2013, we studied the efficacy of MAS3 in 1005 patients with uncomplicated P. falciparum malaria in relation to molecular markers of resistance...
September 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Koukeo Phommasone, Bipin Adhikari, Gisela Henriques, Tiengkham Pongvongsa, Panom Phongmany, Lorenz von Seidlein, Nicholas J White, Nicholas P J Day, Arjen M Dondorp, Paul N Newton, Mallika Imwong, Mayfong Mayxay
BACKGROUND: A large fraction of Plasmodium infections do not cause clinical signs and symptoms of disease and persist at densities in blood that are not detectable by microscopy or rapid diagnostic tests. These infections may be critical as a transmission reservoir in areas of low malaria endemicity. Understanding the epidemiology of these infections would be helpful for malaria elimination. METHODS: A cross-sectional survey was conducted in Thapangthong and Nong Districts of Savannakhet Province, Lao PDR, to determine the prevalence of parasitaemia...
2016: Malaria Journal
Hui Liu, Jian-Wei Xu, Heng-Lin Yang, Mei Li, Cheng-De Sun, Yi-Jie Yin, Zhi-Liang Zheng, Guang-Yun Zhang, Ai-Shui Yu, Yong-Hui Yang, Chun-Hui Li, Shui Ai
BACKGROUND: From 2007 to 2013, intensive control measures reduced malaria burden by 90 % along the China-Myanmar border. However, despite these measures a P. falciparum malaria outbreak was reported in the Shan Special Region II of Myanmar in June of 2014. METHODS: Epidemiological, parasitological and entomological investigations were performed. Dihydroartemisinin piperaquine (DAPQ) was immediately administered to treat parasite positive individuals. Long lasting insecticidal nets (LLIN), indoor residual spraying (IRS) with insecticides and behavior change communication (BCC) were also provided for outbreak control...
April 25, 2016: Infectious Diseases of Poverty
Jian Li, Jiangtao Chen, Dongde Xie, Urbano Monsuy Eyi, Rocio Apicante Matesa, Maximo Miko Ondo Obono, Carlos Sala Ehapo, Liye Yang, Huitian Yang, Min Lin
OBJECTIVE: With emergence and geographically expanding of antimalarial resistance worldwide, molecular markers are essential tool for surveillance of resistant Plasmodium parasites. Recently, single-nucleotide polymorphisms (SNPs) in the PF3D7_1343700 kelch propeller (K13-propeller) domain are shown to be associated with artemisinin (ART) resistance in vivo and in vitro. This study aims to investigate the ART resistance-associated polymorphisms of K13-propeller and PfATPase6 genes in Plasmodium falciparum isolates from Bioko Island, Equatorial Guinea (EG)...
April 2016: International Journal for Parasitology, Drugs and Drug Resistance
Kyaw Myo Tun, Atthanee Jeeyapant, Mallika Imwong, Min Thein, Sai Soe Moe Aung, Tin Maung Hlaing, Prayoon Yuentrakul, Cholrawee Promnarate, Mehul Dhorda, Charles J Woodrow, Arjen M Dondorp, Elizabeth A Ashley, Frank M Smithuis, Nicholas J White, Nicholas P J Day
BACKGROUND: Artemisinin resistance in Plasmodium falciparum extends across Southeast Asia where it is associated with worsening partner drug resistance and a decline in the efficacy of frontline artemisinin-based combination therapy. Dihydroartemisinin-piperaquine (DP) is an essential component of preventive and curative treatment in the region, but its therapeutic efficacy has fallen in Cambodia. METHODS: A prospective clinical and parasitological evaluation of DP was conducted at two sites in Upper Myanmar between August 2013 and December 2014, enrolling 116 patients with acute uncomplicated falciparum malaria...
2016: Malaria Journal
Rupam Tripura, Thomas J Peto, Jeremy Chalk, Sue J Lee, Pasathorn Sirithiranont, Chea Nguon, Mehul Dhorda, Lorenz von Seidlein, Richard J Maude, Nicholas P J Day, Mallika Imwong, Nicholas J White, Arjen M Dondorp
BACKGROUND: Subclinical Plasmodium parasitaemia is an important reservoir for the transmission and persistence of malaria, particularly in low transmission areas. METHODS: Using ultrasensitive quantitative PCR (uPCR) for the detection of parasitaemia, the entire population of three Cambodian villages in Pailin province were followed for 1 year at three-monthly intervals. A cohort of adult participants found initially to have asymptomatic malaria parasitaemia was followed monthly over the same period...
2016: Malaria Journal
Toshihiro Mita, Richard Culleton, Nobuyuki Takahashi, Masatoshi Nakamura, Takahiro Tsukahara, Carol W Hunja, Zin Zayar Win, Wah Win Htike, Aung S Marma, Lek Dysoley, Mathieu Ndounga, Mawuli Dzodzomenyo, Willis S Akhwale, Jun Kobayashi, Haruki Uemura, Akira Kaneko, Francis Hombhanje, Marcelo U Ferreira, Anders Björkman, Hiroyoshi Endo, Jun Ohashi
The emergence and spread of artemisinin-resistant Plasmodium falciparum is of huge concern for the global effort toward malaria control and elimination. Artemisinin resistance, defined as a delayed time to parasite clearance following administration of artemisinin, is associated with mutations in the Pfkelch13 gene of resistant parasites. To date, as many as 60 nonsynonymous mutations have been identified in this gene, but whether these mutations have been selected by artemisinin usage or merely reflect natural polymorphism independent of selection is currently unknown...
June 2016: Antimicrobial Agents and Chemotherapy
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