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Interleukin-33

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https://www.readbyqxmd.com/read/29133357/myeloid-derived-suppressor-cells-ameliorate-cyclosporine-a-induced-hypertension-in-mice
#1
Valorie L Chiasson, Kelsey R Bounds, Piyali Chatterjee, Lochana Manandhar, Abhinandan R Pakanati, Marcos Hernandez, Bilal Aziz, Brett M Mitchell
The calcineurin inhibitor cyclosporine A (CsA) suppresses the immune system but promotes hypertension, vascular dysfunction, and renal damage. CsA decreases regulatory T cells and this contributes to the development of hypertension. However, CsA's effects on another important regulatory immune cell subset, myeloid-derived suppressor cells (MDSCs), is unknown. We hypothesized that augmenting MDSCs would ameliorate the CsA-induced hypertension and vascular and renal injury and dysfunction and that CsA reduces MDSCs in mice...
November 13, 2017: Hypertension
https://www.readbyqxmd.com/read/29131267/interleukin-33-promotes-the-inflammatory-reaction-in-chronic-rhinosinusitis-with-nasal-polyps-by-nf-%C3%AE%C2%BAb-signaling-pathway
#2
L Zhang, L-L Jiang, Z-W Cao
OBJECTIVE: Interleukin (IL)-33 promotes T helper (Th2) immune response and may be involved in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). Using murine and human specimens, we evaluated the role of IL-33 in CRSwNP. MATERIALS AND METHODS: To establish CRSwNP, Balb/c mice were sensitized with house dust mite, followed up by intranasal exposure to Staphylococcus aureus to stimulate the inflammatory response of nasal mucosa. The hematoxylin-eosin staining and total serum IgE were used to the successful construction of CRSwNP model...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29127199/the-full-length-interleukin-33-flil33-importin-5-interaction-does-not-regulate-flil33-s-nuclear-localization-but-controls-its-intracellular-degradation
#3
Andrew Clerman, Zahid Noor, Rita Fishelevich, Virginia Lockatell, Brian S Hampton, Nirav G Shah, Mariah V Salcedo, Nevins W Todd, Sergei P Atamas, Irina G Luzina
Human mature interleukin-33 (MIL33) is a member of the IL-1 family and a potent regulator of immunity through its pro-T helper cell 2 (Th2) activity. Its precursor form, full-length interleukin-33 (FLIL33), is an intranuclear protein in many cell types, including fibroblasts, and its intracellular levels can change in response to stimuli. However, the mechanisms controlling the nuclear localization of FLIL33 or its stability in cells are not understood. Here, we identified importin-5 (IPO5), a member of the importin family of nuclear transport proteins, as an intracellular binding partner of FLIL33...
November 10, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29122645/interleukin-33-levels-are-elevated-in-chronic-allograft-dysfunction-of-kidney-transplant-recipients-and-promotes-epithelial-to-mesenchymal-transition-of-human-kidney-hk-2-cells
#4
Zhen Xu, Chunchun Zhao, Zijie Wang, Jun Tao, Zhijian Han, Wei Zhang, Ruoyun Tan, Min Gu
This study is aimed to investigate the potential role of interleukin (IL)-33 in transplanted kidney interstitial fibrosis and the associated mechanism. Serum IL-33 levels were detected using an enzyme-linked immunosorbent assay (ELISA) in healthy volunteers, stable kidney transplantation recipients (KTRs) (stable), KTRs with acute rejection (AR), and KTRs with chronic allograft dysfunction (CAD) (CAD). Immunohistochemical (IHC) staining, Western blotting, and quantitative real-time PCR (qRT-PCR) were used to detect the expression of IL-33 in human kidney tissues obtained from control and CAD patients...
November 6, 2017: Gene
https://www.readbyqxmd.com/read/29107673/tranilast-inhibits-interleukin-33-production-by-macrophages
#5
Sachiko Hiraide, Yoshiki Yanagawa, Kenji Iizuka
Tranilast is an anti-allergy medication that inhibits the release of chemical mediators such as histamine. However, the mechanisms underlying its anti-allergy effects are not fully understood. Interleukin (IL)-33, a novel member of the IL-1 cytokine family, promotes T helper type 2 immune responses and plays a pathogenic role in allergic disorders. In the present study, we examined the effects of tranilast on IL-33 production by RAW264.7 macrophages. Lipopolysaccharide (LPS) increased both IL-33 mRNA expression and IL-33 protein synthesis...
October 28, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29099650/new-insights-into-graft-versus-host-disease-and-graft-rejection
#6
Eric Perkey, Ivan Maillard
Allogeneic transplantation of foreign organs or tissues has lifesaving potential, but can lead to serious complications. After solid organ transplantation, immune-mediated rejection mandates the use of prolonged global immunosuppression and limits the life span of transplanted allografts. After bone marrow transplantation, donor-derived immune cells can trigger life-threatening graft-versus-host disease. T cells are central mediators of alloimmune complications and the target of most existing therapeutic interventions...
November 3, 2017: Annual Review of Pathology
https://www.readbyqxmd.com/read/29095435/double-stranded-rna-released-from-damaged-articular-chondrocytes-promotes-cartilage-degeneration-via-toll-like-receptor-3-interleukin-33-pathway
#7
Changwei Li, Kaizhe Chen, Hui Kang, Yufei Yan, Kewei Liu, Changjun Guo, Jin Qi, Kai Yang, Fei Wang, Lei Guo, Chuan He, Lianfu Deng
Pattern recognition receptors (PRRs), including Toll-like receptor 3 (TLR3), are involved in arthritic responses; however, whether interleukin-33 (IL-33) is involved in TLR3-mediated cartilage degeneration is unknown. Here, we found that IL-33 was abundantly increased in chondrocytes of osteoarthritis, especially the chondrocytes of weight-bearing cartilage. Furthermore, double-stranded RNA (dsRNA) released from damaged articular chondrocytes induced by mechanical stretching upregulated IL-33 expression to a greater degree than IL-1β and tumor necrosis factor-α...
November 2, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29045903/hpari-protein-secreted-by-a-helminth-parasite-suppresses-interleukin-33
#8
Megan Osbourn, Dinesh C Soares, Francesco Vacca, E Suzanne Cohen, Ian C Scott, William F Gregory, Danielle J Smyth, Matilda Toivakka, Andrea M Kemter, Thierry le Bihan, Martin Wear, Dennis Hoving, Kara J Filbey, James P Hewitson, Holly Henderson, Andrea Gonzàlez-Cìscar, Claire Errington, Sonja Vermeren, Anne L Astier, William A Wallace, Jürgen Schwarze, Alasdair C Ivens, Rick M Maizels, Henry J McSorley
Infection by helminth parasites is associated with amelioration of allergic reactivity, but mechanistic insights into this association are lacking. Products secreted by the mouse parasite Heligmosomoides polygyrus suppress type 2 (allergic) immune responses through interference in the interleukin-33 (IL-33) pathway. Here, we identified H. polygyrus Alarmin Release Inhibitor (HpARI), an IL-33-suppressive 26-kDa protein, containing three predicted complement control protein (CCP) modules. In vivo, recombinant HpARI abrogated IL-33, group 2 innate lymphoid cell (ILC2) and eosinophilic responses to Alternaria allergen administration, and diminished eosinophilic responses to Nippostrongylus brasiliensis, increasing parasite burden...
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/29045902/epidermal-growth-factor-receptor-expression-licenses-type-2-helper-t-cells-to-function-in-a-t-cell-receptor-independent-fashion
#9
Carlos M Minutti, Sebastian Drube, Natalie Blair, Christian Schwartz, Jame C McCrae, Andrew N McKenzie, Thomas Kamradt, Michal Mokry, Paul J Coffer, Maria Sibilia, Alice J Sijts, Padraic G Fallon, Rick M Maizels, Dietmar M Zaiss
Gastro-intestinal helminth infections trigger the release of interleukin-33 (IL-33), which induces type-2 helper T cells (Th2 cells) at the site of infection to produce IL-13, thereby contributing to host resistance in a T cell receptor (TCR)-independent manner. Here, we show that, as a prerequisite for IL-33-induced IL-13 secretion, Th2 cells required the expression of the epidermal growth factor receptor (EGFR) and of its ligand, amphiregulin, for the formation of a signaling complex between T1/ST2 (the IL-33R) and EGFR...
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/28985997/il-33-gene-variants-and-protein-expression-in-pediatric-tunisian-asthmatic-patients
#10
Rihab Charrad, Wajih Kaabachi, Anissa Berraies, Kamel Hamzaoui, Agnès Hamzaoui
Interleukin-33 (IL-33) is one of the last discovered members of the human IL-1 family. It is involved in the pathogenesis of many inflammatory diseases. This study investigates the relationship between IL33 gene variants and serum protein levels with the development of childhood asthma. We analyzed in this case-control study the distribution of two IL33 polymorphisms, rs7044343 and rs1342326, within 200 Tunisian children, using predefined Taqman genotyping assays. IL-33 serum levels were assessed by commercial sandwich Enzyme-linked immunosorbent assay (ELISA)...
October 3, 2017: Cytokine
https://www.readbyqxmd.com/read/28981455/a-unique-tgfb1-driven-genomic-program-links-astrocytosis-low-grade-inflammation-and-partial-demyelination-in-spinal-cord-periplaques-from-progressive-multiple-sclerosis-patients
#11
Serge Nataf, Marc Barritault, Laurent Pays
We previously reported that, in multiple sclerosis (MS) patients with a progressive form of the disease, spinal cord periplaques extend distance away from plaque borders and are characterized by the co-occurrence of partial demyelination, astrocytosis and low-grade inflammation. However, transcriptomic analyses did not allow providing a comprehensive view of molecular events in astrocytes vs. oligodendrocytes. Here, we re-assessed our transcriptomic data and performed co-expression analyses to characterize astrocyte vs...
October 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28977161/the-relationship-between-circulating-irisin-retinol-binding-protein-4-adiponectin-and-inflammatory-mediators-in-patients-with-metabolic-syndrome
#12
Omur Tabak, Gonul Simsek, Fusun Erdenen, Volkan Sozer, Tuna Hasoglu, Remise Gelisgen, Esma Altunoglu, Cuneyt Muderrisoglu, Abdulhalim Senyigit, Hafize Uzun
OBJECTIVE: We wanted to investigate whether there is a relationship between circulating irisin, retinol binding protein-4 (RBP-4), adiponectin and proinflammatory mediators implicated in the development of insulin resistance (IR) in metabolic syndrome (MetS). SUBJECTS AND METHODS: In 180 individuals, including controls and patients with MetS, we measured fasting plasma insulin, high sensitivity C-reactive protein (hsCRP), pentraxin-3 (PTX-3), interleukin-33 (IL-33), irisin, RBP-4, and adiponectin using ELISA kits...
September 18, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28974430/predictive-value-of-low-interleukin-33-in-critically-ill-patients
#13
Konstantin A Krychtiuk, Stefan Stojkovic, Max Lenz, Mira Brekalo, Kurt Huber, Johann Wojta, Gottfried Heinz, Svitlana Demyanets, Walter S Speidl
Patients admitted to a medical intensive care unit (ICU) are characterized by an activated immune system and exhibit a high mortality rate irrespective of the underlying cause of admission. Interleukin (IL)-33 has been shown to be protective in experimental sepsis models and it has been demonstrated that circulating levels of its "decoy" receptor soluble ST2 (sST2) are associated with outcome in critically ill patients. The aim of the present study was to investigate whether circulating IL-33 is associated with 30-day mortality in patients admitted to a medical ICU...
September 30, 2017: Cytokine
https://www.readbyqxmd.com/read/28966754/comparison-of-interleukin-33-serum-levels-in-asthmatic-patients-with-a-control-group-and-relation-with-the-severity-of-the-disease
#14
Tooba Momen, Hamid Ahanchian, Mohsen Reisi, Seyedeh Azra Shamsdin, Armindokht Shahsanai, Majid Keivanfar
BACKGROUND: The relation between interleukin-33 (IL-33) and asthma is not precisely known yet. The present study set to compare the serum level of IL-33 in patients with asthma and controls and study the relation with the severity of disease. METHODS: The serum level of IL-33 and total IgE in 89 asthmatic patients and 57 controls were analyzed. The association of levels of IL-33 with the severity of disease, levels of total IgE, measures of spirometry (forced expiratory volume in 1 s [FEV1]), age, sex, presence or absence of other allergic diseases, and the disease duration was evaluated...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28965952/interleukin-33-attenuates-doxorubicin-induced-cardiomyocyte-apoptosis-through-suppression-of-ask1-jnk-signaling-pathway
#15
Yongwei Yao, Rong Chen, Chunyang Ying, Guohui Zhang, Tao Rui, Aibin Tao
Interleukin-33 (IL-33), a new member of the IL-1 cytokine family, has cardiac protective effect in many circumstances. The aims of present study are to assess whether IL-33 can protect cardiomyocytes from doxorubicin (DOX)-induced apoptosis and the mechanism involved in the protection. Cardiomyocytes derived from either wild-type or c-Jun N-terminal kinase deficient (JNK(-/-)) mice were challenged with DOX (1  μM) with or without IL-33 (10 ng/ml). Myocyte apoptosis was assessed by measuring Caspase 3 activity, fragmented DNA and the TUNEL staining...
November 25, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28960823/changes-in-inflammatory-mediators-as-a-result-of-intermittent-hypoxia-in-obstructive-sleep-apnea-syndrome
#16
Volkan Sozer, Müge Kutnu, Ersan Atahan, Buket Calıskaner Ozturk, Ergi Hysi, Cansu Cabuk, Benan Musellim, Gonul Simsek, Hafize Uzun
BACKGROUND: Inflammation plays an important role in obstructive sleep apnea syndrome (OSAS). The objective of this study was to investigate the relationship of serum C-reactive protein(CRP), pentraxin-3(PTX-3), procalcitonin(ProCT), interleukin-33(IL-33) and its soluble receptor ST2 (sST2) with the syndrome severity and to show theirs importance as biomarkers. METHODS: This study comprises a total of 84 identical (sex and age wise) cases. Full-night polysomnography was performed in each patient...
September 29, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28943296/il-33-exacerbates-liver-sterile-inflammation-by-amplifying-neutrophil-extracellular-trap-formation
#17
Hamza O Yazdani, Hui-Wei Chen, Samer Tohme, Sheng Tai, Dirk J van der Windt, Patricia Loughran, Brian R Rosborough, Vikas Sud, Donna Beer-Stolz, Heth R Turnquist, Allan Tsung, Hai Huang
BACKGROUND: Neutrophils and Liver sinusoidal endothelial cells (LSECs) both contribute to sterile inflammatory injury during ischemia/reperfusion (I/R), a well-known liver surgical stress. Interleukin-33 (IL-33) has been shown to drive neutrophil infiltration during inflammatory responses through its receptor ST2. We recently reported that infiltrating neutrophils form neutrophil extracellular traps (NETs), which exacerbate sterile inflammatory injury in liver I/R. Here, we sought to determine the role of IL-33 in NET formation during liver sterile inflammation...
September 21, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28919759/association-of-interleukin-33-gene-polymorphisms-with-susceptibility-to-late-onset-alzheimer-s-disease-a-meta-analysis
#18
Xin Zhong, Ming-Yan Liu, Miao He, Ke Du, Min-Jie Wei
The association between interleukin-33 (IL-33) gene polymorphisms and late onset Alzheimer's disease (LOAD) remains controversial in previous studies. Thus, a meta-analysis was conducted to assess the association between the IL-33 polymorphisms (rs11792633 and rs7044343) and LOAD susceptibility. Crude odds ratio (OR) and 95% confidence interval (CI) were used to investigate the relationship strength. Sensitivity analysis was performed, and publication bias was estimated by the Begg's and Egger's tests. Overall, six independent studies involving 2,589 patients and 8,414 control samples met our inclusion criteria and were included in this meta-analysis...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28898270/cyclic-stretch-induced-il-33-production-through-hmgb1-tlr-4-signaling-pathway-in-murine-respiratory-epithelial-cells
#19
Jing Chang, Yuefeng Xia, Karla Wasserloos, Meihong Deng, Kory J Blose, David A Vorp, Heth R Turnquist, Timothy R Billiar, Bruce A Pitt, Ma-Zhong Zhang, Li-Ming Zhang
Interleukin 33 (IL-33), an inflammatory and mechanically responsive cytokine, is an important component of a TLR4-dependent innate immune process in mucosal epithelium. Although TLR4 also plays a role in sensing biomechanical stretch, a pathway of stretch-induced TLR4-dependent IL-33 biosynthesis has not been revealed. In the current study, we show that short term (6 h) cyclic stretch (CS) of cultured murine respiratory epithelial cells (MLE-12) increased intracellular IL-33 expression in a TLR4 dependent fashion...
2017: PloS One
https://www.readbyqxmd.com/read/28889151/hydrogen-water-ameliorates-the-severity-of-atopic-dermatitis-like-lesions-and-decreases-interleukin-1%C3%AE-interleukin-33-and-mast-cell-infiltration-in-nc-nga-mice
#20
Takuya Kajisa, Takuji Yamaguchi, Ailing Hu, Nobuhiro Suetake, Hiroyuki Kobayashi
OBJECTIVES: To examine the effect of hydrogen water (HW) on the severity of atopic dermatitis (AD) and elucidate the underlying pathophysiological mechanisms. METHODS: For this experimental study between March 2015 and December 2015, NC/Nga mice characterized by mild AD severity were given either HW (n=11) or purified water (PW) (n=9) ad libitum; specific-pathogen-free mice (n=9) were used as AD-free control. Atopic dermatitis severity score and transepidermal water loss (TEWL) were examined at baseline (0 week), and after 4 weeks of HW/PW treatment...
September 2017: Saudi Medical Journal
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