keyword
MENU ▼
Read by QxMD icon Read
search

Bis

keyword
https://www.readbyqxmd.com/read/28231422/adiponitrile-litfsi-solution-as-alkylcarbonate-free-electrolyte-for-lto-nmc-li-ion-batteries
#1
Douaa Farhat, Fouad Ghamouss, Julia Maibach, Kristina Edström, Daniel Lemordant
Recently, dinitriles (NC(CH2)nCN) and especially adiponitrile (ADN, n=4) have attracted the attention as secure electrolyte solvents due to their chemical stability, high boiling points, high flash points and low vapor pressure. The good solvating properties of ADN toward lithium salts and its high electrochemical stability (~ 6V vs. Li/Li+) make it suitable for safer Li-ions cells without performances loss. In this study, ADN is used as a single electrolyte solvent with lithium bis(trimethylsulfonyl)imide (LiTFSI)...
February 23, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28230989/development-of-the-first-generation-of-disulfide-based-subtype-selective-and-potent-covalent-pyruvate-dehydrogenase-kinase-1-pdk1-inhibitors
#2
Yifu Liu, Zuoquan Xie, Dan Zhao, Jin Zhu, Fei Mao, Shuai Tang, Hui Xu, Cheng Luo, Mei-Yu Geng, Min Huang, Jian Li
Pyruvate dehydrogenase kinases (PDKs) are overexpressed in most cancer cells and are responsible for aberrant glucose metabolism. We previously described Bis(4-morpholinyl thiocarbonyl)-disulfide (JX06, 16) as the first covalent inhibitor of PDK1. Here, based on the scaffold of 16, we identify two novel types of disulfide-based PDK1 inhibitors. The most potent analog, 3a, effectively inhibits PDK1 both at the molecular (kinact/Ki = 4.17×103M-1s-1) and the cellular level (down to 0.1 μM). In contrast to 16, 3a is a potent and subtype-selective inhibitor of PDK1 with >40-fold selectivity for PDK2-4...
February 23, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28230850/metal-and-additive-free-photoinduced-borylation-of-haloarenes
#3
Adelphe M Mfuh, Brett D Schneider, Westley Cruces, Oleg V Larionov
Boronic acids and esters have critical roles in the areas of synthetic organic chemistry, molecular sensors, materials science, drug discovery, and catalysis. Many of the current applications of boronic acids and esters require materials with very low levels of transition metal contamination. Most of the current methods for the synthesis of boronic acids, however, require transition metal catalysts and ligands that must be removed via additional purification procedures. This protocol describes a simple, metal- and additive-free method of conversion of haloarenes directly to boronic acids and esters...
March 2017: Nature Protocols
https://www.readbyqxmd.com/read/28230754/green-hydroselenation-of-aryl-alkynes-divinyl-selenides-as-a-precursor-of-resveratrol
#4
Gelson Perin, Angelita M Barcellos, Eduardo Q Luz, Elton L Borges, Raquel G Jacob, Eder J Lenardão, Luca Sancineto, Claudio Santi
A simple and efficient protocol to prepare divinyl selenides has been developed by the regio- and stereoselective addition of sodium selenide species to aryl alkynes. The nucleophilic species was generates in situ, from the reaction of elemental selenium with NaBH₄, utilizing PEG-400 as the solvent. Several divinyl selenides were obtained in moderate to excellent yields with selectivity for the (Z,Z)-isomer by a one-step procedure that was carried out at 60 °C in short reaction times. The methodology was extended to tellurium, giving the desired divinyl tellurides in good yields...
February 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28230362/oxidation-of-%C3%AE-ketoamides-the-synthesis-of-vicinal-tricarbonyl-amides
#5
Yueyang Liu, Zhiguo Zhang, Yameng Wan, Guisheng Zhang, Zhonglian Li, Jingjing Bi, Nana Ma, Tong-Xin Liu, Qingfeng Liu
A facile and direct oxidative reaction for the synthesis of vicinal tricarbonyl amides (VTAs) in moderate to excellent yields (53%-88%) was developed starting from readily available β-ketoamides in the presence of phenyliodine(III) bis(trifluoroacetate) (PIFA). The resulting products possess significant synthetic potential, making this approach a valuable addition to the traditional methods already available for the preparation of these molecules.
February 23, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28230283/low-band-gap-bistetracene-based-organic-semiconductors-exhibiting-air-stability-high-aromaticity-and-mobility
#6
Kamal Sbargoud, Masashi Mamada, Tanguy Jousselin-Oba, Yasunori Takeda, Shizuo Tokito, Abderrahim Yassar, Jérôme Marrot, Michel Frigoli
The benchmark of soluble organic semiconductors based on acenes is the 6,13-bis(triisopropylsilylethynyl)pentacene (TIPS-PEN). However TIPS-PEN still suffers from photoinduced oxidation due to its low aromaticity. Increasing the aromaticity while keeping similar optical and electrochemical properties and shape suitable for good transport can be achieved with two-dimensional polycyclic aromatic hydrocarbons (2D-PAHs). Herein, we present an efficient synthesis and characterization of bistetracene derivatives that exhibit a band gap up to 1...
February 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28230220/small-molecule-activation-sbf3-auto-ionization-supported-by-transfer-and-mesoionic-nhc-rearrangement
#7
Blaž Alič, Aleš Štefančič, Gašper Tavčar
The reactivity of antimony trifluoride, SbF3, in non-polar aprotic solvents has been unexplored due to its negligible solubility. The reaction of the [SbF3(tmen)] complex (2) with the N-heterocyclic carbene, 1,3-bis(2,6-diisopropylphenyl)imidazole-2-ylidene, (L(Dipp)), probably leads to the formation of a neutral [(L(Dipp))SbF3] intermediate (3) in non-polar solvents. Mild heat treatment of the reaction mixture unexpectedly activates the SbF3 molecules to undergo the auto-ionization reaction. In this process, one of the (L(Dipp)) ligands undergoes rearrangement into the mesoionic carbene (MIC) and further coordinates to the cation to form [(L(Dipp))2SbF2](+)[SbF4](-), product (4)...
February 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28229949/predicting-reactivity-of-model-dom-compounds-towards-chlorine-with-mediated-electrochemical-oxidation
#8
Glen Andrew de Vera, Wolfgang Gernjak, Jelena Radjenovic
Chlorine demand of a water sample depends on the characteristics of dissolved organic matter (DOM). It is an important parameter for water utilities used to assess oxidant and/or disinfectant consumption of source waters during treatment and distribution. In this study, model compounds namely resorcinol, tannic acid, vanillin, cysteine, tyrosine, and tryptophan were used to represent the reactive moieties of complex DOM mixtures. The reactivity of these compounds was evaluated in terms of Cl2 demand and electron donating capacity (EDC)...
January 23, 2017: Water Research
https://www.readbyqxmd.com/read/28229500/money-for-microbes-pathogen-avoidance-and-out-group-helping-behaviour
#9
Michael Laakasuo, Nils Köbis, Jussi Palomäki, Markus Jokela
Humans have evolved various adaptations against pathogens, including the physiological immune system. However, not all of these adaptations are physiological: the cognitive mechanisms whereby we avoid potential sources of pathogens-for example, disgust elicited by uncleanliness-can be considered as parts of a behavioural immune system (BIS). The mechanisms of BIS extend also to inter-group relations: Pathogen cues have been shown to increase xenophobia/ethnocentrism, as people prefer to keep their societal in-group norms unaltered and "clean...
February 23, 2017: International Journal of Psychology: Journal International de Psychologie
https://www.readbyqxmd.com/read/28229494/cobalt-catalyzed-regioselective-borylation-of-arenes-n-heterocyclic-silylene-as-electron-donors-in-metal-mediated-activation-of-c%C3%AF-h-bonds
#10
Chunming Cui, Hailong Ren, Yu-Peng Zhou, Yun-Ping Bai, Matthias Driess
C-H Borylation of arenes has been a subject of great current interest because of its atom-economy and the wide applicability of borylated products in value-added synthesis. A new bis(silylene)cobalt(II) complex bearing a bis(N-heterocyclic silylene)-pyridine pincer ligand (SiNSi) has been synthesized and structurally characterized. It enabled the regioselective catalytic C-H borylation of pyridines, furans and fluorinated arenes. Notably, it exhibited the complementary regioselectivity for the borylation of fluorinated arenes compared to previously known catalytic systems, demonstrating that N-heterocyclic silylene donors have enormous potential in metal-catalyzed catalytic applications...
February 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28229152/an-anionic-metal-organic-framework-with-ternary-building-units-for-rapid-and-selective-adsorption-of-dyes
#11
Shuo Yao, Tong Xu, Nian Zhao, Lirong Zhang, Qisheng Huo, Yunling Liu
A novel metal-organic framework, [(CH3)2NH2]2[Cu3O(SO4)3Cu2L2(DMF)(H2O)]·9DMF (JLU-Liu39) H2L = pyridine-3,5-bis(phenyl-4-carboxylic acid), has been successfully synthesized under solvothermal conditions. Structure analysis indicates that the framework of JLU-Liu39 is constructed by ternary building units which include a rare hexa-nuclear [Cu6O2(SO4)6] cluster, a classical [Cu2(CO2)4] paddlewheel, and a 3-connected hetero-N, O donor ligand. The whole 3D framework possesses a (3,4,4)-connected fjh topology and a large window size of 25...
February 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28229146/c4-ferrocenylsilyl-bridged-and-substituted-n-heterocyclic-carbenes-complexation-of-germanium-chloride
#12
Yuzhong Wang, Hunter P Hickox, Pingrong Wei, Gregory H Robinson
While the 1 : 1 reaction of C4-trichlorosilyl-functionalized N-heterocyclic carbene (NHC) (2) with [(η(5)-C5H4Li)2Fe]3[TMEDA]2 (3) gives C4-sila[1]ferrocenophane-substituted NHC (4), C4-ferrocenylsilyl-bridged bis-NHC (6) is synthesized by combining 3 with C4-chlorodimethylsilyl-functionalized NHC (5) in a 1 : 2 ratio, (compound 5 is prepared by reaction of the anionic N-heterocyclic dicarbene (NHDC) [:C{[N(2,6-Pr(i)2C6H3)]2CHCLi}]n (1) with Me2SiCl2). In addition, ligand 4- and 6-based GeCl2 complexes (7 and 8) are also synthesized...
February 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28228855/a-new-class-of-organogelators-based-on-triphenylmethyl-derivatives-of-primary-alcohols-hydrophobic-interactions-alone-can-mediate-gelation
#13
Wangkhem P Singh, Rajkumar S Singh
In the present work, we have explored the use of the triphenylmethyl group, a commonly used protecting group for primary alcohols as a gelling structural component in the design of molecular gelators. We synthesized a small library of triphenylmethyl derivatives of simple primary alcohols and studied their gelation properties in different solvents. Gelation efficiency for some of the derivatives was moderate to excellent with a minimum gelation concentration ranging between 0.5-4.0% w/v and a gel-sol transition temperature range of 31-75 °C...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28228039/cell-quintupling-structural-phase-transition-in-a-molecular-crystal-bis-trans-4-butylcyclohexyl-methanol
#14
Kazuya Saito, Takaaki Ikeda, Yasuhisa Yamamura, Hideki Saitoh, Mafumi Hishida, Yutaro Kobayashi, Takeshi Fujita, Junji Ichikawa
A structural phase transition at 151.6 K of the title compound [bis(trans-4-butylcyclohexyl)methanol] is examined by X-ray diffraction crystallography, Fourier-transform infrared spectroscopy, and adiabatic calorimetry. A general consideration on possible superstructures indicates that a single modulation wave is sufficient to drive this cell-quintupling transition. The entropy of transition determined calorimetrically indicates that two conformations are dominant in the room-temperature phase in contrast to the fivefold disorder expected from the structure of the low-temperature phase...
February 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28227981/assessment-of-sedation-analgesia-by-means-of-poincare%C3%AC-analysis-of-the-electroencephalogram
#15
Jose D Bolanos, Montserrat Vallverdu, Pere Caminal, Daniel F Valencia, Xavi Borrat, Pedro L Gambus, Jose F Valencia, Jose D Bolanos, Montserrat Vallverdu, Pere Caminal, Daniel F Valencia, Xavi Borrat, Pedro L Gambus, Jose F Valencia, Jose D Bolanos, Xavi Borrat, Jose F Valencia, Montserrat Vallverdu, Pere Caminal, Pedro L Gambus, Daniel F Valencia
Monitoring the levels of sedation-analgesia may be helpful for managing patient stress on minimally invasive medical procedures. Monitors based on EEG analysis and designed to assess general anesthesia cannot distinguish reliably between a light and deep sedation. In this work, the Poincaré plot is used as a nonlinear technique applied to EEG signals in order to characterize the levels of sedation-analgesia, according to observed categorical responses that were evaluated by means of Ramsay Sedation Scale (RSS)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227693/using-bioimpedance-spectroscopy-parameters-as-real-time-feedback-during-tdcs
#16
Isar Nejadgholi, Herschel Caytak, Miodrag Bolic, Isar Nejadgholi, Herschel Caytak, Miodrag Bolic, Isar Nejadgholi, Miodrag Bolic, Herschel Caytak
An exploratory analysis is carried out to investigate the feasibility of using BioImpedance Spectroscopy (BIS) parameters, measured on scalp, as real-time feedback during Transcranial Direct Current Stimulation (tDCS). TDCS is shown to be a potential treatment for neurological disorders. However, this technique is not considered as a reliable clinical treatment, due to the lack of a measurable indicator of treatment efficacy. Although the voltage that is applied on the head is very simple to measure during a tDCS session, changes of voltage are difficult to interpret in terms of variables that affect clinical outcome...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227494/localised-impedance-monitoring-device-for-the-remote-clinical-assessment-of-home-based-dialysis-patients
#17
A Montalibet, W Arkouche, P Bogonez Franco, S Bonnet, A Clarion, G Delhomme, C Gehin, S Gharbi, R Guillemaud, P Jallon, B Massot, P Pham, E Ribbe-Cornet, E McAdams, A Montalibet, W Arkouche, P Bogonez Franco, S Bonnet, A Clarion, G Delhomme, C Gehin, S Gharbi, R Guillemaud, P Jallon, B Massot, P Pham, E Ribbe-Cornet, E McAdams, B Massot, P Pham, A Montalibet, P Jallon, E Ribbe-Cornet, P Bogonez Franco, G Delhomme, S Bonnet, R Guillemaud, W Arkouche, A Clarion, C Gehin, S Gharbi, E McAdams
BioImpedance Spectroscopy (BIS) has been clinically used to determine the hydrational status of patients undergoing haemodialysis (HD). In the present project we are developing a calf-localised, integrated impedimetric device to periodically and conveniently measure and transmit information on the hydrational status of home-based patients to a remote clinic. Surprisingly, we have found that simple postural changes before or during measurement lead to significant fluid shifts in the lower leg that are as important and as long lasting as the effects of haemodialysis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225274/a-rational-design-of-a-selective-inhibitor-for-kv1-1-channels-prevalent-in-demyelinated-nerves-that-improves-their-impaired-axonal-conduction
#18
Ahmed Al-Sabi, Declan Daly, Patrick Hoefer, Gemma K Kinsella, Charles P E Metais, Mark Pickering, Caroline Herron, Seshu Kumar Kaza, Kieran J Nolan, J Oliver Dolly
K(+) channels containing Kv1.1 α subunits, which become prevalent at internodes in demyelinated axons, may underlie their dysfunctional conduction akin to muscle weakness in multiple sclerosis. Small inhibitors were sought with selectivity for the culpable hyper-polarising K(+) currents. Modelling of interactions with the extracellular pore in a Kv1.1 deduced-structure identified a diaryldi-(2-pyrrolyl)methane (DPM) as a suitable scaffold, with optimised alkyl ammonium side chains. The resultant synthesised candidate [2,2'-((5,5'(di-p-topyldiaryldi-(2-pyrrolyl)methane)bis(2,2'carbonyl)bis (azanediyl)) diethaneamine...
February 22, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28225184/bis-picolinamide-ruthenium-iii-dihalide-complexes-dichloride-to-diiodide-exchange-generates-single-trans-isomers-with-high-potency-and-cancer-cell-selectivity
#19
Aida M Basri, Rianne M Lord, Simon J Allison, Andrea Rodríguez-Bárzano, Stephanie J Lucas, Felix D Janeway, Helena J Shepherd, Christopher M Pask, Roger M Phillips, Patrick Columba McGowan
A library of new bis-picolinamide ruthenium(III) dihalide complexes of the type RuX2L2 (X = Cl or I and L = picolinamide) have been synthesized and characterized. They exhibit different picolinamide ligand binding modes, whereby one ligand is bound (N,N) and the other bound (N,O). Structural studies reveal a mixture of cis and trans isomers for the RuCl2L2 complexes but upon a halide exchange reaction to RuI2L2, only single trans isomers are present. High cytotoxic activity against human cancer cell lines was observed, with potencies for some complexes similar to or better than cisplatin...
February 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28225113/solvent-controlled-reversible-switching-between-adsorbed-self-assembled-nanoribbons-and-nanotubes
#20
Asad Jamal, Irina Nyrkova, Philippe Mesini, Swann Militzer, Günter Reiter
We have demonstrated that solutions of 3,5-bis-(5-hexylcarbamoylpentyloxy)-benzoic acid decyl ester (BHPB-10) can form metastable nanostructures on solid substrates and in the bulk. BHPB-10 is an achiral molecule involving several distinct, strongly interacting groups (SIGs), one aromatic-ester ring and two amide groups per molecule. Specific solvents affect the interactions between particular SIGs, thus promoting various nano-structures: lamellae, nanoribbons, helical ribbons, or nanotubes. In cyclohexane, a solvent allowing for both inter-amide hydrogen bonds and mutual attraction of rings, the formation of nanotubes with a diameter of 28 ± 5 nm was observed in the bulk and on surfaces...
February 22, 2017: Nanoscale
keyword
keyword
5436
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"