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https://www.readbyqxmd.com/read/29140695/rna-g-quadruplexes-in-kirsten-ras-kras-oncogene-as-targets-for-small-molecules-inhibiting-translation
#1
Giulia Miglietta, Susanna Cogoi, Jessica Marinello, Giovanni Capranico, Alexander S Tikhomirov, Andrey E Shchekotikhin, Luigi E Xodo
The human KRAS transcript contains a G-rich 5'-UTR sequence (77 % GC) harbouring several G4 motifs capable to form stable RNA G-quadruplex (RG4) structures that can serve as targets for small molecules. A biotin-streptavidin pull-down assay showed that 4,11-bis(2-aminoethylamino)anthra[2,3-b]furan-5,10-dione (2a) binds to RG4s in the KRAS transcript under low-abundance cellular conditions. Dual-luciferase assays demonstrated that 2a and its analogue 4,11-bis(2-aminoethylamino)anthra[2,3-b]thiophene-5,10-dione 2b) repress translation in a dose-dependent manner...
November 15, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29140603/protic-nnn-and-ncn-pincer-type-ruthenium-complexes-featuring-trifluoromethyl-pyrazole-arms-synthesis-and-application-to-catalytic-hydrogen-evolution-from-formic-acid
#2
Yoshiko Nakahara, Tatsuro Toda, Asuka Matsunami, Yoshihito Kayaki, Shigeki Kuwata
The NNN and NCN pincer-type ruthenium(II) complexes featuring two protic pyrazol-3-yl arms with a trifluoromethyl (CF3) group at the 5-position were synthesized and structurally characterized to evaluate the impact of the substitution on the properties and catalysis. The Brønsted acidity increased by the highly electron-withdrawing CF3 pendants was demonstrated by the protonation-deprotonation experiments. By contrast, the infrared spectra of the carbonyl derivatives as well as the cyclic voltammogram indicated that the electron density of the ruthenium atom is little influenced by the CF3 group...
November 15, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29140082/self-assembly-and-catalytic-reactivity-of-binol-bridged-bis-phenanthroline-metallocages
#3
Kai-Yu Cheng, Shi-Cheng Wang, Yu-Sheng Chen, Yi-Tsu Chan
Upon treatment with Zn(II) ions, a series of BINOL-bridged bis(phenanthroline) ligands was self-assembled into [M2L3] metallocages, which were carefully characterized by NMR spectroscopy and ESI-MS spectrometry. Among them, a racemic mixture of the BINOL-bridged bis(phenanthrolines) underwent chiral self-sorting to afford two homochiral metallocages. The narcissistic self-sorting process of the metallocages was observed in the complexation reaction of the constitutionally isomeric bis(phenanthrolines) with varying connection positions...
November 15, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29140068/arginine-rich-peptide-induced-supramolecular-self-assembly-of-water-soluble-anionic-alkynylplatinum-ii-complexes-a-continuous-and-label-free-luminescence-assay-for-trypsin-and-inhibitor-screening
#4
Angela Sin-Yee Law, Margaret Ching-Lam Yeung, Vivian Wing-Wah Yam
A water-soluble anionic alkynylplatinum(II) 2,6-bis(benzimidazol-2'-yl)pyridine (bzimpy) complex has been strategically designed and synthesized to show supramolecular self-assembly with cationic arginine-rich peptides through unique noncovalent Pt(II)···Pt(II) and π-π stacking interactions. Upon introduction of trypsin, the arginine-rich peptides can be hydrolyzed into small fragments and deaggregation of the platinum(II) complex molecules is observed. The aggregation-deaggregation process has been probed by UV-vis absorption, emission, and resonance light scattering (RLS) studies...
November 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29139204/subporpholactone-subporpholactam-imidazolosubporphyrin-and-iridium-complexes-of-imidazolosubporphyrin-formation-of-iridium-carbene-complexes
#5
Atsuhiro Osuka, Kota Yoshida
Pyrrole-modified subporphyrins bearing a non-pyrrolic cyclic unit, subporpholactone, subporpholactam, and imidazolosubporphyrin were newly synthesized. They show subporphyrin-like absorption and fluorescence spectra that are red-shifted in the order of subporpholactam < subporpholactone < imidazolosubporphyrin. Metalation of the imidazolosubporphyrin with (pentamethylcyclopentadienyl)iridium(III) dichloride dimer gave a complex, in which the Ir(III) atom was attached at the peripheral nitrogen atom of the imidazole moiety and the ortho-position of the meso-phenyl group...
November 15, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29139160/assessing-the-ligand-properties-of-nhc-stabilized-phosphorus-i-cations
#6
Justin F Binder, Stephanie C Kosnik, Charles Lloyd Bergstrom Macdonald
The isolation and full characterization of a series of cationic metal carbonyl complexes bearing an N-heterocyclic carbene-stabilized phosphorus(I) ligand are reported. Specifically, the mononuclear coordination complexes [LM(CO)₅][BPh₄] (M = Cr, Mo, W), [LFe(CO)₄][BPh₄] and the dinuclear complexes [LMn₂(CO)₈][BPh₄] and [LCo₂(CO)₆][BPh₄], where L = [bis(1,3,4,5-tetramethylimidazol-2-ylidene)phosphanide]+, have all been isolated in the solid state and structurally confirmed by single crystal X-ray diffraction...
November 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29138806/effect-of-bis-hydroxymethyl-alkanoate-curcuminoid-derivative-mth-3-on-cell-cycle-arrest-apoptotic-and-autophagic-pathway-in-triple-negative-breast-adenocarcinoma-mda-mb-231-cells-an-in-vitro-study
#7
Ling-Chu Chang, Min-Tsang Hsieh, Jai-Sing Yang, Chi-Cheng Lu, Fuu-Jen Tsai, Je-Wei Tsao, Yu-Jen Chiu, Sheng-Chu Kuo, Kuo-Hsiung Lee
Curcumin has been shown to exert potential antitumor activity in vitro and in vivo involved in multiple signaling pathways. However, the application of curcumin is still limited because of its poor hydrophilicity and low bio-availability. In the present study, we investigated the therapeutic effects of a novel and water soluble bis(hydroxymethyl) alkanoate curcuminoid derivative, MTH-3, on human breast adenocarcinoma MDA-MB-231 cells. This study investigated the effect of MTH-3 on cell viability, cell cycle and induction of autophagy and apoptosis in MDA-MB-231 cells...
November 14, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29138773/cooperating-dipole-dipole-and-van-der-waals-interactions-driven-2d-self-assembly-of-fluorenone-derivatives-ester-chain-length-effect
#8
Meiqiu Dong, Kai Miao, Yi Hu, Juntian Wu, Jinxing Li, Peng Pang, Xinrui Miao, Wenli Deng
Two-dimensional supramolecular assemblies of a series of 2,7-bis(10-n-alkoxycarbonyl-decyloxy)-9-fluorenone derivatives (BAF-Cn, n = 1, 3-6) consisting of polar fluorenone moieties and ester alkoxy chains were investigated by scanning tunneling microscopy on highly oriented pyrolytic graphite surfaces. The chain-length effect was observed in the self-assembly of BAF-Cn. Self-assembly of BAF-C1 was composed of a linear I pattern, where the side chains adopted a fully interdigitated arrangement. As the length of side chains increased, the coexistence of a linear I pattern and a cyclic pattern for the self-assembly of BAF-C3 was observed...
November 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29138465/fine-tuning-the-energy-barrier-of-molecular-nanomagnets-via-lattice-solvent-molecules
#9
Cai-Ming Liu, De-Qing Zhang, Dao-Ben Zhu
Solvents play important roles in our lives, they are also of interest in molecular materials, especially for molecular magnets. The solvatomagnetic effect is generally used for trigger and/or regulation of magnetic properties in molecule-based systems, however, molecular nanomagnets showing solvatomagnetic effects are very difficult to obtain. Here we report four 3d-4f heterometallic cluster complexes containing ROH lattice solvent molecules, [Cu3Tb2(H3L)2(OAc)2(hfac)4]∙2ROH {H6L = 1,3-Bis[tris(hydroxymethyl)methylamino]propane, hfac(-) = hexafluoroacetylacetonate; R = CH3, 1; R = C2H5, 2; R = C3H7, 3; R = H, 4}...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137799/ultrasound-irradiation-effect-on-morphological-properties-of-a-3d-nano-zinc-ii-supramolecular-coordination-polymer
#10
Hai Ning Chang, Suo Xia Hou, Zeng Chuan Hao, Guang Hua Cui
Nano-structures of [Zn(L)(atpt)]n (1) (L=1,2-bis(2-methylbenzimidazol-1-ylmethyl)benzene and H2atpt=2-aminoterephthalic acid) were obtained by hydrothermal and sonochemical approaches, characterized by scanning electron microscopy (SEM), IR, powder X-ray diffraction (PXRD), and elemental analysis. CP 1 features a 2D (4,4) network with the point symbol {4(4).6(2)}, the 3D supramolecular architecture in CP 1 is controlled through π⋯π stacking interactions. The influence of various concentrations of initial reagents, power of ultrasound irradiation, and ultrasound time on the morphology and size of nano-structured CP 1 were studied in detail...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137790/thermal-and-morphological-properties-of-nanocomposite-materials-based-on-graphene-oxide-and-l-leucine-containing-poly-benzimidazole-amide-prepared-by-ultrasonic-irradiation
#11
Mohammad Dinari, Elahe Salehi, Amir Abdolmaleki
A new poly(benzimidazole-amide) (PBIA) was fabricated by polycondensation of 1,3-bis(5-amino-1H-benzimidazole-2-yl)benzene with chiral diacid under green media by using tetra-n-butylammonium bromide as a cheap commercially available molten ionic salt at 120°C. The affection of reaction time on the polymer yield and viscosity was tested and optimized for PBIA. Inherent viscosity value of the prepared PBIA under optimized conditions is 0.31dL/g. Then to acquire a uniformly dispersion of graphene oxide (GO) in the PBIA matrix, GO was prepared through strong oxidation procedure...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137773/ultrasonic-assisted-synthesis-of-batio3-nanoparticles-at-25%C3%A2-%C3%A2-c-and-atmospheric-pressure
#12
Songkot Utara, Sitchai Hunpratub
Barium titanate (BaTiO3) nanoparticles were successfully synthesized via a sonochemical method (25 kHz) at a constant temperature of 25 °C and atmospheric pressure without a calcination step. Barium hydroxide Ba(OH)2 and diisopropoxytitanium bis(acetylacetonate) (C12H28O6Ti) were used as the starting materials. The effects of the concentration of NaOH used and ultrasonic reaction time were investigated. The phase composition, functional groups and morphology of synthesized powders were characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Fourier transform Raman spectroscopy (FT-Raman) and transmission electron microscopy (TEM)...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137760/a-novel-high-performance-nano-chemosensor-for-copper-ii-ion-based-on-an-ultrasound-assisted-synthesized-diphenylamine-based-schiff-base-design-fabrication-and-density-functional-theory-calculations
#13
Zohreh Parsaee, Pouya Haratipour, Milad Janghorban Lariche, Arash Vojood
A novel high selective colorimetric chemosensor was introduced based on a nano diphenyl-based Schiff base (H2L), 2,2'-((1E,1'E)-(((hexylazanediyl)bis(4,1-phenylene))bis(methanylylidene))bis(azanylylidene))bis(4-methylphenol) that synthesized using sonochemical method. H2L was characterized by FT-IR, MS, TGA, (1)H NMR, (13)C NMR, SEM and elemental analysis techniques, then fabricated as the portable strips for sensing copper (II) ions in aqueous media. The binding interaction between H2L and various metal ions was investigated by UV-Vis spectroscopic that showed favorable coordination toward Cu(2+) ion...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137744/luminescence-electrochemical-and-photocatalytic-properties-of-sub-micron-nickel-ii-and-cobalt-ii-coordination-polymers-synthesized-by-sonochemical-process
#14
Jun Xuan Li, Yu Feng Li, Li Wei Liu, Guang Hua Cui
Submicron structures of Ni(II)/Co(II)-based coordination polymers (CPs) [Ni(L1)(mip)·H2O]n (1) and {[Co(L2)(mip)]·0·.5H2O}n(2) (L1=1,6-bis(5,6-dimethylbenzimidazole)hexane, L2=1,6-bis(benzimidazole)hexane, H2mip=5-methylisophthalic acid) were obtained by ultrasonic irradiation and structurally characterized by elemental analysis, powder X-ray diffraction and scanning electron microscopy. Structural analysis show that two CPs feature uninodal 3-connected 2D hcb layer, whilst CP 2 is further extended into a 3D complicated supramolecular network by C14-H14⋯O2 hydrogen bonds...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137743/sonochemical-synthesis-of-amide-functionalized-metal-organic-framework-graphene-oxide-nanocomposite-for-the-adsorption-of-methylene-blue-from-aqueous-solution
#15
Mahboobeh Tanhaei, Ali Reza Mahjoub, Vahid Safarifard
Graphene oxide-[Zn2(oba)2(bpfb)]·(DMF)5 metal-organic framework nanocomposite (GO-TMU-23; H2oba=4,4'-oxybisbenzoic acid, bpfb=N,N'-bis-(4-pyridylformamide)-1,4-benzenediamine, DMF=N,N-dimethylformamide) is prepared through a simple and large-scale sonochemical preparation method at room temperature. The obtained nanocomposite is characterized by Field Emission Scanning Electron Microscopy (FE-SEM), powder X-ray diffraction (PXRD) and FT-IR spectroscopy. Additionally, the absorption ability of GO-TMU-23 nanocomposite toward cationic dye methylene blue was also performed...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137737/acoustic-cavitation-in-1-butyl-3-methylimidazolium-bis-triflluoromethyl-sulfonyl-imide-based-ionic-liquid
#16
Slimane Merouani, Oualid Hamdaoui, Boumediene Haddad
In this work, a comparison between the temperatures/pressures within acoustic cavitation bubble in an imidazolium-based room-temperature ionic liquid (RTIL), 1-butyl-3-methylimidazolium bis(triflluoromethyl-sulfonyl)imide ([BMIM][NTf2]), and in water has been made for a wide range of cavitation parameters including frequency (140-1000kHz), acoustic intensity (0.5-1Wcm(-2)), liquid temperature (20-50°C) and external static pressure (0.7-1.5atm). The used cavitation model takes into account the liquid compressibility as well as the surface tension and the viscosity of the medium...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29136462/on-surface-annulation-reaction-cascade-for-the-selective-synthesis-of-diindenopyrene
#17
Frank Eisenhut, Thomas Lehmann, Andreas Viertel, Dmitry Skidin, Justus Krüger, Seddigheh Nikipar, Dmitry A Ryndyk, Christian Joachim, Stefan Hecht, Francesca Moresco, Gianaurelio Cuniberti
We investigated the thermally induced on-surface cyclization of 4,10-bis(2'-bromo-4'-methylphenyl)-1,3-dimethylpyrene to form the previously unknown, non-alternant polyaromatic hydrocarbon diindeno[1,2,3-cd:1´,2´,3´-mn]pyrene on Au(111) using scanning tunneling microscopy and spectroscopy. The observed unimolecular reaction involves thermally induced debromination followed by selective ring-closure to fuse the neighboring benzene moieties via a five-membered ring. The structure of the product has been verified experimentally as well as theoretically...
November 14, 2017: ACS Nano
https://www.readbyqxmd.com/read/29136192/assessing-the-hydration-status-of-children-with-chronic-kidney-disease-and-on-dialysis-a-comparison-of-techniques
#18
Caroline S Y Eng, Devina Bhowruth, Mark Mayes, Lynsey Stronach, Michelle Blaauw, Amy Barber, Lesley Rees, Rukshana C Shroff
Background: Fluid balance is pivotal in the management of children with chronic kidney disease (CKD) and on dialysis. Although many techniques are available to assess fluid status, there are only a few studies for children, of which none have been comparable against cardiovascular outcome measures. Methods: We performed a longitudinal study in 30 children with CKD5-5D and 13 age-matched healthy controls (71 measurements) to determine a correlation between optimal weight by bioimpedance spectroscopy (Wt-BIS) and clinical assessment (Wt-CA)...
November 9, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29136083/differentiation-of-enantiomeric-anions-by-nmr-spectroscopy-with-chiral-bisurea-receptors
#19
Suguru Ito, Manami Okuno, Masatoshi Asami
Chiral anionic species are ubiquitous and play important roles in biological systems. Despite the recent advancements in synthetic anion receptors bearing urea functionalities, urea-based chiral solvating agents (CSAs) that can separate the NMR signals of racemic anions remain limited. Herein, three dibenzofuran-based C2-symmetric chiral bisureas were synthesized from the reaction of (R,R)-4,6-bis(1-aminopropyl)dibenzo[b,d]furan with phenyl isocyanate, phenyl thioisocyanate, or tosyl isocyanate. The chiral anion recognition properties of these bisureas were examined by (1)H NMR spectroscopy using dl-tetrabutylammonium mandelate (TBAM) as a model substrate...
November 14, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29136075/coordinatively-and-electronically-unsaturated-square-planar-cobalt-iii-complexes-of-a-pyridine-dianionic-pincer-ligand
#20
Faidh Hana, Alan J Lough, Gino G Lavoie
A series of low-valent Co(iii) square planar complexes supported by a dianionic pincer ligand bis(arylamido)pyridine ([NNN](2-)) was synthesized, including the first structurally characterized square planar hydroxide complex ([NNN]Co(OH), 4) of a 3d transition metal in the +3 oxidation state. The magnetic properties of the Co(iii) complexes were highly dependent on the charge of the complex and on the coordination environment of the metal. The diamagnetic cationic complex {[NNN]Co(py)}BF4 (2) can be converted to neutral paramagnetic complexes [NNN]Co(OR) (R = Ph 3a, iPr 3b, and H 4) by a simple substitution of the ancillary pyridine ligand in 2...
November 14, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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