Yasuo Shimizu, Hidemasa Kuwabara, Akihiro Ono, Seiichi Higuchi, Takeshi Hisada, Kunio Dobashi, Mitsuyoshi Utsugi, Yoshinori Mita, Masatomo Mori
The balance between CD4(+) T helper (Th1) lymphocytes producing interferon-gamma or Interleukin-4 (Th2) in the lungs may vary among diseases and during the progression of interstitial pneumonia (IP). Both idiopathic pulmonary fibrosis (IPF) and collagen vascular diseases (CVD) are associated with IP, but the clinical course and the response to treatment are different. Since Th1 or Th2 modulating drugs have been proven to alter the lymphocyte balance in vitro, it is important to elucidate the Th1/Th2 profile in patients with active IP...
2006: Immunopharmacology and Immunotoxicology