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Myocardial protection

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https://www.readbyqxmd.com/read/29356453/association-between-1p13-polymorphisms-and-peripheral-arterial-disease-in-a-chinese-population-with-diabetes
#1
Jiangyuan Qin, Jinli Tian, Guanhua Liu, Yazhong Zhang, Luobing Tian, Yanfeng Zhen, Hewei Zhang, Jing Xu, Xueling Sun, Hui Fang
AIMS/INTRODUCTION: Variants on chromosome 1p13 have been associated with coronary artery disease and acute myocardial infarction risk in different ethnics. This study was aimed to investigate the association between 1p13 polymorphisms and the development of peripheral artery disease (PAD) in a Chinese population with type 2 diabetic mellitus (T2DM). MATERIALS AND METHODS: 1p13 polymorphisms rs599839, rs646776 and rs12740374 were assessed in a cohort of 882 T2DM cases including 440 T2DM with PAD (DM+PAD group) and 442 cases without PAD (DM group)...
January 22, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29354958/-action-mechanism-of-acupuncture-along-meridians-on-improving-energy-metabolism-in-cardiomyocytes
#2
Ting Du, Yulan Ren, Yonggang He, Zhihan Chen, Fanrong Liang
OBJECTIVE: To explore the protective effect of acupuncture along meridians on rats with myocardial ischemia and its effect and action mechanism on cardiomyocyte energy metabolism. METHODS: A total of 104 healthy 12-week-old SD rats were fed adaptively for 1 week and included into study with no disease symptoms observed. Of them, 24 SD rats were selected regardless of gender, and were randomly divided into a blank group and a sham operation group, 12 rats in each one...
November 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29353233/cardiovascular-safety-long-term-noncardiovascular-safety-and-efficacy-of-sodium-glucose-cotransporter-2-inhibitors-in-patients-with-type-2-diabetes-mellitus-a-systemic-review-and-meta-analysis-with-trial-sequential-analysis
#3
REVIEW
Xin-Lin Zhang, Qing-Qing Zhu, Yu-Han Chen, Xue-Ling Li, Fu Chen, Jian-An Huang, Biao Xu
BACKGROUND: The cardiovascular and long-term noncardiovascular safety and efficacy of SGLT2 (sodium-glucose cotransporter 2) inhibitors have not been well documented. METHODS AND RESULTS: For cardiovascular outcomes, we performed a meta-analysis with trial sequential analysis of randomized controlled trials and adjusted observational studies, each with a minimum of 26 weeks and 2000 patient-years of follow-up. For long-term noncardiovascular safety and efficacy outcome analyses, we included only randomized controlled trials with at least 2 years and 1000 patient-years of follow-up...
January 20, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29352508/inhibition-of-brd4-attenuates-cardiomyocyte-apoptosis-via-nf-%C3%AE%C2%BAb-pathway-in-a-rat-model-of-myocardial-infarction
#4
Yiping Sun, Ying Xie, Luping Du, Jingwu Sun, Zhiqiang Liu
Myocardial infarction (MI) remains the most common cause of heart failure (HF) worldwide. For almost 50 years, HF has been recognized as a determinant of adverse prognosis after MI, but efforts to promote myocardial repair have failed to be translated into clinical therapies. In the present study, we investigated the effects of BRD4 on cardiac function and the underlying mechanism. We found that BRD4 protein expression was significantly increased in cardiomyocytes of MI rat model and cardiomyocytes under hypoxia, accompanied by the expression of natriuretic peptide A (NPPA) and natriuretic peptide B (NPPB)...
January 20, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29350784/novel-cardiovascular-magnetic-resonance-cmr-oxygenation-approaches-in-understanding-pathophysiology-of-cardiac-diseases
#5
Karthigesh Sree Raman, Gaetano Nucifora, Joseph B Selvanayagam
Cardiovascular Magnetic Resonance Imaging (CMR) permits accurate phenotyping of many cardiac diseases. CMR's inherent advantages are its non-invasive nature, lack of ionizing radiation and high accuracy and reproducibility. Furthermore, it is able to assess many aspects of cardiac anatomy, structure and function. Specifically, it can characterize myocardial tissue, myocardial function, myocardial mass, myocardial blood flow/perfusion, irreversible and reversible injury, all with a high degree of accuracy and reproducibility...
January 19, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29350681/aav-9-mediated-phosphatase-1-inhibitor-1-overexpression-improves-cardiac-contractility-in-unchallenged-mice-but-is-deleterious-in-pressure-overload
#6
D M Schwab, L Tilemann, R Bauer, M Heckmann, A Jungmann, M Wagner, J Burgis, C Vettel, H A Katus, A El-Armouche, O J Müller
The downregulation of β-adrenergic receptors (β-AR) and decreased cAMP-dependent protein kinase activity in failing hearts results in decreased phosphorylation and inactivation of phosphatase-inhibitor-1 (I-1), a distal amplifier element of β-adrenergic signaling, leading to increased protein phosphatase 1 activity and dephosphorylation of key phosphoproteins, including phospholamban. Downregulated and hypophosphorylated I-1 likely contributes to β-AR desensitization; therefore its modulation is a promising approach in heart failure treatment...
January 19, 2018: Gene Therapy
https://www.readbyqxmd.com/read/29348013/dose-dependent-cardioprotection-of-moderate-32%C3%A2-c-versus-mild-35%C3%A2-c-therapeutic-hypothermia-in-porcine-acute%C3%A2-myocardial-infarction
#7
Rajesh Dash, Yoshiaki Mitsutake, Wook Bum Pyun, Fady Dawoud, Jennifer Lyons, Atsushi Tachibana, Kazuyuki Yahagi, Yuka Matsuura, Frank D Kolodgie, Renu Virmani, Michael V McConnell, Uday Illindala, Fumiaki Ikeno, Alan Yeung
OBJECTIVES: The study investigated whether a dose response exists between myocardial salvage and the depth of therapeutic hypothermia. BACKGROUND: Cardiac protection from mild hypothermia during acute myocardial infarction (AMI) has yielded equivocal clinical trial results. Rapid, deeper hypothermia may improve myocardial salvage. METHODS: Swine (n = 24) undergoing AMI were assigned to 3 reperfusion groups: normothermia (38°C) and mild (35°C) and moderate (32°C) hypothermia...
January 22, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29345338/miat-lncrna-is-overexpressed-in-breast-cancer-and-its-inhibition-triggers-senescence-and-g1-arrest-in-mcf7-cell-line
#8
Firooz Jannat Alipoor, Malek Hossein Asadi, Masoud Torkzadeh-Mahani
Long non-coding RNAs are known as key regulators in the progression and metastasis of breast cancer. Miat originally has been considered as an lncRNA to be associated with a susceptibility to myocardial infarction. Here, we have detected the expression of Miat in different cancer cells and a series of breast tumor tissue. Miat expression was much higher in high-grade tumors compared to low-grade ones. Unlike P53 positive tumors, Miat expression was upregulated in ER, PR, Her2 positive tumor tissues. Knockdown Miat suppressed breast cancer cell proliferation and caused G1 arrest in cell cycle...
January 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29344719/phosphorylation-of-vasodilator-stimulated-phosphoprotein-contributes-to-myocardial-ischemic-preconditioning
#9
David Köhler, Sofia-Iris Bibli, Lothar P Klammer, Judith M Roth, Rainer Lehmann, Ingrid Fleming, Tiago F Granja, Andreas Straub, Peter M Benz, Peter Rosenberger
Ischemic preconditioning (IP) is a well-known strategy to protect organs against cell death following ischemia. The previous work has shown that vasodilator-stimulated phosphoprotein (VASP) is involved in cytoskeletal reorganization and that it holds significant importance for the extent of myocardial ischemia reperfusion injury. Yet, the role of VASP during myocardial IP is, to date, not known. We report here that VASP phosphorylation at serine157 and serine239 is induced during hypoxia in vitro and during IP in vivo...
January 17, 2018: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29344670/pgc-1%C3%AE-ameliorates-kidney-fibrosis-in-mice-with-diabetic-kidney-disease-through-an-antioxidative-mechanism
#10
Liwen Zhang, Jian Liu, Fangfang Zhou, Weiming Wang, Nan Chen
The production of reactive oxygen species (ROS) is a common phenomenon in podocyte impairment, which leads to the irreversible progression of chronic kidney diseases, such as diabetic kidney disease (DKD). Previous research has indicated that peroxisome proliferator‑activated receptor γ (PPARγ) coactivator‑1α (PGC‑1α) participates in mitochondrial biogenesis and energy metabolism in certain mitochondria‑enriched cells, including myocardial and skeletal muscle cells. Therefore, we hypothesized that PGC‑1α may be a protective nuclear factor against energy and oxidative stress in DKD...
January 16, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29344374/cardioprotection-by-an-anti-masp-2-antibody-in-a-murine-model-of-myocardial-infarction
#11
James E Clark, Thomas Dudler, Michael S Marber, Wilhelm Schwaeble
Background: Myocardial ischaemia-reperfusion injury is a major cause of mortality and morbidity in the developed world. Many approaches have been investigated to counteract the pathological consequences associated with acute myocardial infarction (AMI) and cardiac remodelling. It is accepted that inflammation, and therefore activation of the complement pathway, is a crucial step in the pathogenesis of this injury, and many attempts have been made to ameliorate the infarction and consequent dysfunction using anticomplement therapy, with mixed success...
2018: Open Heart
https://www.readbyqxmd.com/read/29341932/synthetic-extracellular-matrix-mimic-hydrogel-improves-efficacy-of-mesenchymal-stromal-cell-therapy-for-ischemic-cardiomyopathy
#12
Maria Chiara Ciuffreda, Giuseppe Malpasso, Cindy Chokoza, Deon Bezuidenhout, Kyle P Goetsch, Manuela Mura, Federica Pisano, Neil H Davies, Massimiliano Gnecchi
BACKGROUND: Mesenchymal stromal cells (MSC) repair infarcted hearts mainly through paracrine mechanisms. Low cell engraftment limits the release of soluble paracrine factors (SF) over time and, consequently, MSC efficacy. We tested whether a synthetic extracellular matrix mimic, a hydrogel containing heparin (H-HG), could ameliorate MSC engraftment and binding/release of SF, thus improving MSC therapy efficacy. METHODS AND RESULTS: In vitro, rat bone-marrow MSC (rBM-MSC) were seeded and grown into H-HG...
January 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29341322/isthmus-sites-identified-by-ripple-mapping-are-usually-anatomically-stable-a-novel-method-to-guide-atrial-substrate-ablation
#13
Vishal Luther, Norman Qureshi, Phang Boon Lim, Michael Koa-Wing, Shahnaz Jamil-Copley, Fu Siong Ng, Zachary Whinnett, D Wyn Davies, Nicholas S Peters, Prapa Kanagaratnam, Nick Linton
BACKGROUND: Post ablation reentrant ATs depend upon conducting isthmuses bordered by scar. Bipolar voltage maps highlight scar as sites of low voltage, but the voltage amplitude of an electrogram depends upon the myocardial activation sequence. Furthermore, a voltage threshold that defines atrial scar is unknown. We used Ripple Mapping (RM) to test whether these isthmuses were anatomically fixed between different activation vectors and atrial rates. METHODS: We studied post-AF ablation ATs where > 1 rhythm was mapped...
January 17, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29341213/detection-of-subclinical-left-ventricular-dysfunction-by-tissue-doppler-imaging-in-horses-with-aortic-regurgitation
#14
S Ven, A Decloedt, D De Clercq, L Vera, F Rademakers, G van Loon
BACKGROUND: Aortic regurgitation (AR) can have an important clinical impact and in some cases leads to left ventricular (LV) failure. Tissue Doppler imaging (TDI) is an echocardiographic technique that has been used in horses to detect LV dysfunction. OBJECTIVES: To examine whether TDI detects changes in radial myocardial wall motion in horses with AR compared to control horses. STUDY DESIGN: Case-control study. METHODS: Echocardiography was performed in 30 healthy Warmblood horses and 34 Warmblood horses with AR, subdivided in groups with mild, moderate or severe AR...
January 17, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29340805/cardiorespiratory-fitness-and-cardiovascular-disease-prevention-an-update
#15
REVIEW
Mouaz H Al-Mallah, Sherif Sakr, Ada Al-Qunaibet
PURPOSE OF REVIEW: Cardiovascular diseases account for nearly one third of all deaths globally. Improving exercise capacity and cardiorespiratory fitness (CRF) has been an important target to reduce cardiovascular events. In addition, the American Heart Association defined decreased physical activity as the fourth risk factor for coronary artery disease. Multiple large cohort studies have evaluated the impact of CRF on outcomes. In this review, we will discuss the role of CRF in reducing cardiovascular morbidity and mortality...
January 16, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29340110/curcumin-attenuates-myocardial-ischemia-reperfusion-injury
#16
Kun Liu, Honglin Chen, Qing-Sheng You, Qing Ye, Fei Wang, Shuo Wang, Shuang-Long Zhang, Kang-Jun Yu, Qi Lu
Background: Cardiovascular diseases (CVDs) are at a badly high-risk of morbidity and mortality in the world. Methods: Our study was attempted to investigate the cardioprotective role of curcumin. Hearts injury was assessed in isolated hearts and the rats of coronary artery ligated. Results and Conclusions: The inhibition of pro-inflammatory cytokines was observed by curcumin in coronary artery ligated rats. ST segment was also reduced by curcumin...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29340072/hyperbaric-oxygen-protects-against-myocardial-reperfusion-injury-via-the-inhibition-of-inflammation-and-the-modulation-of-autophagy
#17
Chunxia Chen, Wan Chen, Yaoxuan Li, Yanling Dong, Xiaoming Teng, Zhihuan Nong, Xiaorong Pan, Liwen Lv, Ying Gao, Guangwei Wu
Our previous study demonstrated that hyperbaric oxygen (HBO) preconditioning protected against myocardial ischemia reperfusion injury (MIRI) and improved myocardial infarction. However, HBO's effect on MIRI-induced inflammation and autophagy remains unclear. In this study, we investigate the potential impact and underlying mechanism of HBO preconditioning on an MIRI-induced inflammatory response and autophagy using a ligation of the left anterior descending (LAD) coronary artery rat model. Our results showed that HBO restored myocardial enzyme levels and decreased the apoptosis of cardiomyocytes, which were induced by MIRI...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339693/simultaneous-total-occlusion-of-two-coronary-arteries-associated-with-use-of-drospirenone-ethinyl-estradiol-oral-contraceptive
#18
Hüsnü Atmaca, Diyar Köprülü, Tuncay Kiriş, Gönül Zeren, İrfan Şahin
Although the use of oral contraceptives is associated with an increased risk of venous thromboembolic disease, the risk of myocardial infarction (MI) is unclear. A new, third-generation contraceptive agent, drospirenone-ethinyl estradiol, which contains less estrogen and a new progestogen, drospirenone, in a different combination, has been considered more reliable in terms of risk of MI. However, there have been some cases of MI associated with the use of drospirenone-ethinyl estradiol, despite the protective effects of this oral contraceptive...
January 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29339262/the-long-term-physical-and-psychological-health-impacts-of-flooding-a-systematic-mapping
#19
REVIEW
Shuang Zhong, Lianping Yang, Sam Toloo, Zhe Wang, Shilu Tong, Xiaojie Sun, David Crompton, Gerard FitzGerald, Cunrui Huang
BACKGROUND: Flooding has caused significant and wide ranging long-term health impacts for affected populations. However, until now, the long-term health outcomes, epidemiological trends and specific impact factors of flooding had not been identified. In this study, the relevant literature was systematically mapped to create the first synthesis of the evidence of the long-term health impacts of flooding. METHODS: The systematic mapping method was used to collect and categorize all the relevant literature...
January 13, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29337195/secretoneurin-suppresses-cardiac-hypertrophy-through-suppression-of-oxidant-stress
#20
Hua-Li Chen, Yan Liu, Wei Jiang, Xiao-Xiao Wang, Guo-Lin Yuan, Yi-Lin Zhao, Chao Yu
The neuropeptide secretoneurin (SN) plays protective roles in myocardial ischemia. In the present study, the effect of SN in cardiac hypertrophy was investigated. We observed that, in isoproterenol (ISO) treatment induced cardiac or cardiomyocytes hypertrophy, a marked increase in the expression of endogenous SN in mouse plasma, myocardium and primary-cultured cardiomyocytes occurs. In hypertrophic mice, the heart size, heart weight/body weight (HW/BW) ratio, cardiomyocyte size, and atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) expression were significantly higher than those in controls but were effectively suppressed by SN gene therapy...
January 11, 2018: European Journal of Pharmacology
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