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Maciej Sobkowski, Zbigniew Celewicz, Jarosław Kalinka, Krzysztof Szymanowski, Marcin Serafin, Katarzyna Śmieja, Anna Grzymała-Figura, Kinga Pacocha, Izabela Pieniążek, Jacek Walczak, Agnieszka Żyła, Adam Bierut
OBJECTIVES: The aim of this study was to compare the costs of using carbetocin in the prevention of uterine atony following delivery of the infant by Cesarean section (C-section) under epidural or spinal anesthesia with standard methods of prevention (SMP). MATERIAL AND METHODS: This retrospective multicenter study was based on data from three medical centers. A questionnaire was developed to gather patient records on consumption and costs of resources related to C-section, prevention of uterine atony and postpartum hemorrhage (PPH) treatment...
2016: Ginekologia Polska
Sung Hye Byun, So Young Lee, Seong Yeon Hong, Taeha Ryu, Baek Jin Kim, Jin Yong Jung
INTRODUCTION: In fetuses who are predicted to be at risk of catastrophic airway obstruction at delivery, the ex utero intrapartum treatment (EXIT) procedure is useful for securing the fetal airway while maintaining fetal oxygenation via placental circulation. Factors, including poor posture of the fetus and physician, narrow visual field, and issues of contamination in the aseptic surgical field, make fetal intubation during the EXIT procedure difficult. Herein, we report our experience of the usefulness of the GlideScope video laryngoscope (GVL) for intubation during the EXIT procedure...
September 2016: Medicine (Baltimore)
Mohammad Ahmed Maher, Tarek Mohammad Sayyed, Nabih Ibrahim Elkhouly
OBJECTIVES: To compare between three different utertonics (oxytocin, carbetocin, and misoprostol) given via three different routes (intra-umbilical, intravenous, and sublingual, respectively) in reducing the need for manual removal of placenta. METHODS: A randomized trial for cases with retained placenta 30 minutes following vaginal delivery. They received intraumbilical oxytocin, intravenous carbetocin, or sublingual misoprostol. Main outcome measures were delivery of the placenta within 30 minutes following drug administration, and need for manual removal of placenta...
September 27, 2016: Journal of Maternal-fetal & Neonatal Medicine
(no author information available yet)
BestBETs for Vets are generated by the Centre for Evidence-based Veterinary Medicine at the University of Nottingham to help answer specific questions and assist in clinical decision making. Although evidence is often limited, they aim to find, present and draw conclusions from the best available evidence, using a standardised framework. A more detailed description of how BestBETs for Vets are produced was published in VR, April 4, 2015, vol 176, pp 354-356.
August 13, 2016: Veterinary Record
John J Morrison, David A Crosby, Denis J Crankshaw
Uterine atony is a major cause of postpartum haemorrhage and maternal mortality. However, the comparative pharmacology of agents used to treat this condition is poorly understood. This study evaluates, using human pregnant myometrium in vitro, a range of contractile parameters for agents used in the clinical treatment of atonic postpartum haemorrhage. The effects of oxytocin, carbetocin, ergometrine, carboprost, syntometrine and misoprostol were investigated in 146 myometrial strips from 19 donors. The potency and maximal response values were obtained, and compared, using both maximal amplitude and mean contractile force as indices of contraction...
October 15, 2016: European Journal of Pharmacology
Ahmed E H Elbohoty, Walid E Mohammed, Mohamed Sweed, Ahmed M Bahaa Eldin, Ashraf Nabhan, Karim H I Abd-El-Maeboud
OBJECTIVE: To compare the effectiveness and safety of carbetocin, misoprostol, and oxytocin for the prevention of postpartum hemorrhage following cesarean deliveries. METHODS: A double-blind randomized controlled trial enrolled patients with a singleton pregnancy scheduled for an elective cesarean delivery at a maternity hospital in Cairo, Egypt, between October 1, 2012 and June 30, 2013. Participants were randomized using a computer-generated sequence to receive treatment with carbetocin, misoprostol, or oxytocin...
September 2016: International Journal of Gynaecology and Obstetrics
Ahmed Mohamed Maged, Ahmed Shaker Ragab, Noura Elnassery, Walaa Ai Mostafa, Sherif Dahab, Amal Kotb
OBJECTIVE: To compare effectiveness and tolerability of carbetocin versus syntometrine in prevention of postpartum hemorrhage (PPH) after cesarean section (CS). METHODS: A double-blind randomized study conducted on 300 pregnant subjected randomly either to single 100 μg IV dose of carbetocin (150 women) or combination of 5 IU oxytocin and 0.2 mg ergometrine (150 women) after fetal extraction and before placental removal. Primary outcome parameter was the occurrence of PPH...
June 8, 2016: Journal of Maternal-fetal & Neonatal Medicine
Fernanda Francine Zimmermann, Karina Vidarte Gaspary, Anna Maria Siebel, Carla Denise Bonan
Changes in social behavior occur in several neuropsychiatric disorders such as schizophrenia and autism. The interaction between individuals is an essential aspect and an adaptive response of several species, among them the zebrafish. Oxytocin is a neuroendocrine hormone associated with social behavior. The aim of the present study was to investigate the effects of MK-801, a non-competitive antagonist of glutamate NMDA receptors, on social interaction and aggression in zebrafish. We also examined the modulation of those effects by oxytocin, the oxytocin receptor agonist carbetocin and the oxytocin receptor antagonist L-368,899...
September 15, 2016: Behavioural Brain Research
Benjamin Deniau, Nacima Bouhadjari, Valentina Faitot, Antoine Mortazavi, Gilles Kayem, Laurent Mandelbrot, Hawa Keita
OBJECTIVE: To assess the performance of a multidisciplinary programme for enhanced recovery after caesarean delivery under neuraxial anaesthesia. STUDY DESIGN: Prospective single-centre study. METHODS: Programme in 6 steps including 3 professional practice audits based on clinical records and questioning patients: audit T0, first "existing state", creation of a working group, drafting and implementation of a multidisciplinary rehabilitation procedure, second audit (T0+4 months), information about and implementation of corrective measures and a third audit (T0+8 months)...
April 27, 2016: Anaesthesia, Critical Care & Pain Medicine
Salome Dell-Kuster, Irene Hoesli, Olav Lapaire, Esther Seeberger, Luzius A Steiner, Heiner C Bucher, Thierry Girard
BACKGROUND: The two most commonly used uterotonic drugs in caesarean section are oxytocin and carbetocin, a synthetic oxytocin analogue. Carbetocin has a longer half-life when compared to oxytocin, resulting in a reduced use of additional uterotonics. Oxytocin is known to cause fewer cardiovascular side effects when administered as a short-infusion compared to as an intravenous bolus. Based on these findings, we aim at comparing carbetocin 100 mcg given as a slow intravenous bolus with carbetocin 100 mcg applied as a short-infusion in 100 ml 0...
2016: Trials
Mariana Widmer, Gilda Piaggio, Hany Abdel-Aleem, Guillermo Carroli, Yap-Seng Chong, Arri Coomarasamy, Bukola Fawole, Shivaprasad Goudar, G Justus Hofmeyr, Pisake Lumbiganon, Kidza Mugerwa, Thi My Huong Nguyen, Zahida Qureshi, Joao Paulo Souza, A Metin Gülmezoglu
BACKGROUND: Postpartum haemorrhage (PPH) is the leading cause of maternal mortality in low-income countries and contributes to nearly a quarter of maternal deaths globally. The current available interventions for prevention of postpartum haemorrhage, oxytocin and carbetocin, are limited by their need for refrigeration to maintain potency, as the ability to maintain a cold chain across the drug distribution and storage network is inconsistent, thus restricting their use in countries with the highest burden of maternal mortality...
2016: Trials
Xiaolu Meng, Fang Shen, Chunlu Li, Yonghui Li, Xuewei Wang
Tree shrews, a species phylogenetically close to primates, are regarded as a suitable and naturalistic animal model for depression studies. However, psychological symptoms that are essential for depression diagnosis and treatment, such as helplessness and social withdrawal, have not been studied in this model. Therefore, in this study, we first investigated learned helplessness, social interaction and sucrose preference induced by two chronic stress paradigms: uncontrollable foot shocks (1-week foot shocks) and multiple unpredictable stimuli (1-week foot shocks and 3-week unpredictable stressors) in tree shrews...
June 2016: Pharmacology, Biochemistry, and Behavior
Carole-Anne Whigham, Alexandra Gorelik, Terrence E Loughnan, Amar Trivedi
OBJECTIVE: We compared the efficacy of Carbetocin (long-acting oxytocin receptor agonist) versus Oxytocin given at non-elective caesarean section. METHOD: We performed a double-blind, randomised, single-centre study. Eligible women were ≥37 weeks of gestation undergoing emergency caesarean section. Participants received either carbetocin of 100 μg or oxytocin 5 international units. The primary outcome was the need to administer additional uterotonics, as determined by the clinician...
December 2016: Journal of Maternal-fetal & Neonatal Medicine
P P Tang, H Y Hu, J S Gao, J Hu, Y F Zhong, T Wang, Y N Song, X Y Zhou, J Q Yang, J T Liu, J Pan, H F Shi
OBJECTIVE: To evaluate the efficacy and safety of pelvic arterial embolization (PAE) in women with intractable primary postpartum hemorrhage (PPH). METHODS: Clinical data of 36 cases were analyzed retrospectively in which women underwent PAE for intractable primary PPH in Peking Union Medical College Hospital between Jan 2006 and Jan 2015. The success rate of PAE were measured and possible predictive risk factors associated with treatment failure were analyzed. The complications secondary to PAE were also recorded...
February 2016: Zhonghua Fu Chan Ke za Zhi
Nuguelis Razali, Ida Lilywaty Md Latar, Yoo Kuen Chan, Siti Zawiah Omar, Peng Chiong Tan
OBJECTIVE: To evaluate the uterotonic effect of carbetocin compared with oxytocin in emergency cesarean delivery. STUDY DESIGN: Participants were randomized to intravenous bolus injection of 100mcg carbetocin or 10IU oxytocin after cesarean delivery of the baby. The primary outcome is any additional uterotonic which may be administered by the blinded provider for perceived inadequate uterine tone with or without hemorrhage in the first 24hours after delivery. Secondary outcomes include operating time, perioperative blood loss, change in hemoglobin and hematocrit levels, blood transfusion and reoperation for postpartum hemorrhage...
March 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Naida M Cole, Jose C A Carvalho, Magda Erik-Soussi, Nivetha Ramachandran, Mrinalini Balki
BACKGROUND: The purpose of this study was to compare in vitro contractile effects of oxytocin and carbetocin on human term pregnant myometrium with and without oxytocin pretreatment. METHODS: This laboratory investigation was conducted on myometrial samples from women undergoing elective cesarean deliveries. The samples were dissected into four strips and suspended in individual organ bath chambers containing physiologic salt solution. After equilibration, they were pretreated with oxytocin 10 M (experimental group) or physiologic salt solution (control group) for 2 h and then subjected to dose-response testing with increasing concentrations of oxytocin or carbetocin (10 to 10 M)...
February 2016: Anesthesiology
Ahmed Mohamed Maged, AbdelGany M A Hassan, Nesreen A A Shehata
OBJECTIVE: The objective of this study is to compare the effectiveness and safety of carbetocin vs. oxytocin in the management of atonic post partum haemorrhage (PPH) after vaginal delivery. METHODS: A prospective randomised study was conducted in which 100 pregnant women were randomised into 2 equal groups: group 1 received Carbetocin 100 µgm (Pabal(®) Ferring, UK) and group 2 received oxytocin 5 IU (Syntocinon(®), Novartis, Switzerland). RESULTS: The amount of blood loss and the need for other uterotonics were significantly lower in the carbetocin group (811 ± 389...
May 2016: Archives of Gynecology and Obstetrics
Polymnia Georgiou, Panos Zanos, Juan-Antonio Garcia-Carmona, Susanna Hourani, Ian Kitchen, Brigitte L Kieffer, Maria-Luisa Laorden, Alexis Bailey
Relapse to illicit drug-seeking following abstinence is a major challenge for the treatment of addiction as no effective pharmacotherapy is available. We have recently shown that activating the central oxytocinergic system prevents emotional impairment and stress-induced reinstatement associated with opioid withdrawal. Here, we investigated whether the oxytocin analogue carbetocin (CBT) is able to reverse morphine-primed reinstatement of conditioned-place preference (CPP) in mice. The mechanism underlining the behavioural effect of CBT was investigated by assessing the involvement of the striatal noradrenergic and dopaminergic systems in CBT reversal of priming- and stress-induced reinstatement of opioid CPP...
December 2015: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
W Zaremba, T Udluft, H Bostedt
OBJECTIVE: The effects of various parturition controlling measures in sows on the relevant parameters for parturition were investigated. MATERIAL AND METHODS: A total of 1975 study animals were divided into five groups: control group: A (n = 710); trial groups: B (n = 719), C (n = 180), D (n = 175), E (n = 191). The control group (A) included sows that spontaneously farrowed until day 114 of gestation. The remaining sows were administered a PGF2α-analogue (175 µg cloprostenol) on day 114...
2015: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
Jérôme Mairesse, Eleonora Gatta, Marie-Line Reynaert, Jordan Marrocco, Sara Morley-Fletcher, Marion Soichot, Lucie Deruyter, Gilles Van Camp, Hammou Bouwalerh, Francesca Fagioli, Anna Pittaluga, Delphine Allorge, Ferdinando Nicoletti, Stefania Maccari
Oxytocin receptors are known to modulate synaptic transmission and network activity in the hippocampus, but their precise function has been only partially elucidated. Here, we have found that activation of presynaptic oxytocin receptor with the potent agonist, carbetocin, enhanced depolarization-evoked glutamate release in the ventral hippocampus with no effect on GABA release. This evidence paved the way for examining the effect of carbetocin treatment in "prenatally restraint stressed" (PRS) rats, i.e., the offspring of dams exposed to repeated episodes of restraint stress during pregnancy...
December 2015: Psychoneuroendocrinology
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