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Aeroallergen

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https://www.readbyqxmd.com/read/29774148/genetic-variations-in-the-tlr3-locus-are-associated-with-eosinophilic-esophagitis
#1
Robledo Ávila-Castellano, José-Raúl García-Lozano, Stefan Cimbollek, Alfredo J Lucendo, Juan-Manuel Bozada, Joaquín Quiralte
Background: Eosinophilic esophagitis (EoE) is an antigen-driven disease mediated by an abnormal immune Th2 response. Objective: The objective of this article is to investigate genes associated with regulating immune responses leading to disease susceptibility. Methods: Twenty-seven tag single nucleotide polymorphisms (tSNPs) selected in five candidate genes ( TLR3, TLR4, FOXP3, FLG and TSLP ) were genotyped in 218 EoE patients and 376 controls...
April 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29766006/interaction-between-air-pollutants-and-pollen-grains-the-role-on-the-rising-trend-in-allergy
#2
Farnaz Sedghy, Abdol-Reza Varasteh, Mojtaba Sankian, Malihe Moghadam
Asthma and allergic diseases cases have risen in recent decades. Plant pollen is considered as the main aeroallergen causing allergic reactions. According to available data, urban residents experience more respiratory allergies than rural residents mainly due to the interaction between chemical air pollutants and pollen grains. This interaction can occur through several mechanisms; chemical pollutants might facilitate pollen allergen release, act as adjuvants to stimulate IgE-mediated responses, modify allergenic potential, and enhance the expression of some allergens in pollen grains...
April 2018: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29732293/skin-prick-test-reactivity-to-aeroallergens-in-adult-allergy-clinic-in-thailand-a-12-year-retrospective-study
#3
Supa Oncham, Umaporn Udomsubpayakul, Wannada Laisuan
Background: The global prevalence of allergic rhinitis, asthma, and atopic dermatitis has risen significantly over the last 2 decades. Allergic sensitization to aeroallergen is a major risk factor in developing the allergic disease. The prevalence of aeroallergen sensitization varies in different regions and countries. Objective: To determine the prevalence of common aeroallergen sensitization and the atopic status among adult patients. Methods: A cross-sectional, retrospective study...
April 2018: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29723941/-characterization-of-children-younger-than-five-years-with-suspected-allergic-diseases
#4
Laura Mar Vásquez, Manuela Olaya, Daniela Cleves, Luis Fernando Ramírez-Zuluaga, Carlos Serrano
BACKGROUND: Symptoms of allergic diseases are a common cause of consultation during childhood. OBJECTIVE: To describe the profile of a population of Colombian preschool children seen in an allergology department and assess possible risk factors. METHODS: Descriptive, cross-sectional study of patients younger than 5 years who were assessed for one year. A complete medical history was obtained and allergology workup was carried out with skin prick tests as appropriate for each case...
January 2018: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29723938/-prevalence-of-sensitization-and-allergy-to-kiwi-fruit-actinidia-deliciosa-in-adults-with-allergic-diseases
#5
Tonatiuh Ramses Bedolla-Pulido, Silvia Araceli Álvarez-Corona, Tonantzin Isis Bedolla-Pulido, Benjamín Uribe-Cota, Tania González-Mendoza, Martín Bedolla-Barajas
BACKGROUND: The kiwi fruit (Actinidia deliciosa) is a food that has been recognized for its allergenic capability for more than 30 years. In general, kiwi allergy is characterized by local discomfort, but systemic reactions such as rash, angioedema, rhinitis, conjunctivitis or anaphylaxis can be triggered. OBJECTIVE: To determine the prevalence of sensitization and allergy to kiwi in adults with allergic diseases. METHODS: By means of a cross-sectional, retrolective study, data corresponding to 370 patients aged ≥16 years were analyzed...
January 2018: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29678409/phototherapy-for-neonatal-hyperbilirubinemia-and-childhood-eczema-rhinitis-and-wheeze
#6
Elizabeth Huiwen Tham, Evelyn Xiu Ling Loo, Anne Goh, Oon Hoe Teoh, Fabian Yap, Kok Hian Tan, Keith M Godfrey, Hugo Van Bever, Bee Wah Lee, Yap Seng Chong, Lynette Pei-Chi Shek
BACKGROUND: The pathogenesis of allergic diseases in childhood may be attributed to influences of early environmental stimuli on fetal and neonatal immune regulation. Neonatal hyperbilirubinemia is common in the Asian population and up to 20% of infants require phototherapy. We examined the hypothesis that phototherapy for neonatal hyperbilirubinemia modulates the infant's risk of developing eczema, rhinitis and wheeze in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort...
March 24, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29677491/the-allergen-der-p3-from-house-dust-mite-stimulates-store-operated-ca-2-channels-and-mast-cell-migration-through-par4-receptors
#7
Yu-Ping Lin, Charmaine Nelson, Holger Kramer, Anant B Parekh
The house dust mite is the principal source of perennial aeroallergens in man. How these allergens activate innate and adaptive immunity is unclear, and therefore, there are no therapies targeting mite allergens. Here, we show that house dust mite extract activates store-operated Ca2+ channels, a common signaling module in numerous cell types in the lung. Activation of channel pore-forming Orai1 subunits by mite extract requires gating by STIM1 proteins. Although mite extract stimulates both protease-activated receptor type 2 (PAR2) and PAR4 receptors, Ca2+ influx is more tightly coupled to the PAR4 pathway...
April 19, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29670037/expression-and-regulation-of-thymic-stromal-lymphopoietin-and-thymic-stromal-lymphopoietin-receptor-heterocomplex-in-the-innate-adaptive-immunity-of-pediatric-asthma
#8
REVIEW
Sheng-Chieh Lin, Fang-Yi Cheng, Jun-Jen Liu, Yi-Ling Ye
Asthma is a chronic inflammatory disease affecting the airway, and it is characterized by a wheezing breathing sound, variable airflow obstruction and the presence of inflammatory cells in the submucosa of the bronchi. Viral infection, pollutants and sensitivity to aeroallergens damage the epithelium from childhood, which causes asthma. The pathogenesis of asthma includes pathways of innate stimulation by environmental microbes and irritant pathogens. Damaged epithelial cells produce thymic stromal lymphopoietin (TSLP) and stimulate myeloid dendritic cell maturation through the thymic stromal lymphopoietin receptor (TSLPR) heterocomplex...
April 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29667465/association-of-serum-specific-ige-levels-with-asthma-in-autumn-pollen-induced-allergic-rhinitis-a-retrospective-analysis
#9
Le Cui Md, Jia Yin Md
BACKGROUND: Artemisia and Humulus pollen are the two most important aeroallergens of autumn allergies in North China. Cross-sectional data in 2001 have shown that allergic rhinitis often preceded or occurred at the same time as asthma in patients with autumn pollinosis in North China. OBJECTIVE: We used this cross-sectional data to investigate the association of serum specific IgE (sIgE) levels to Humulus and/or Artemisia pollen with the onset of asthma in patients with autumn pollen-induced allergic rhinitis...
April 18, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29642904/relationships-between-aeroallergen-levels-and-hospital-admissions-for-asthma-in-the-brussels-capital-region-a-daily-time-series-analysis
#10
Ariane Guilbert, Bianca Cox, Nicolas Bruffaerts, Lucie Hoebeke, Ann Packeu, Marijke Hendrickx, Koen De Cremer, Sandrine Bladt, Olivier Brasseur, An Van Nieuwenhuyse
BACKGROUND: Outdoor pollen grain and fungal spore concentrations have been associated with severe asthma exacerbations at the population level. The specific impact of each taxon and the concomitant effect of air pollution on these symptoms have, however, still to be better characterized. This study aimed to investigate the short-term associations between ambient concentrations of various aeroallergens and hospitalizations related to asthma in the Brussels-Capital Region (Belgium), an area recording especially high rates of admissions...
April 11, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29629055/accuracy-of-immunoblotting-assay-for-detection-of-specific-ige-compared-with-immunocap-in-allergic-patients
#11
Raheleh Shokouhi Shoormasti, Mohammad Reza Fazlollahi, Anoshirvan Kazemnejad, Masoud Movahedi, Behnoosh Tayebi, Zahra Yazdanyar, Zakieh Azadi, Zahra Pourpak, Mostafa Moin
Background and aim: Standardized techniques help us to better diagnosis and follow up of allergic diseases. In this study, we determined the sensitivity, accuracy, and specificity of an Immunoblotting test compared to ImmunoCAP as the reference in vitro test for detection of specific IgE in allergic patients. Methods: In this cross-sectional study, specific IgE level was determined in patients with allergic symptoms who referred to the Immunology, Asthma and Allergy Research Institute, Tehran, Iran from 2010-2016, by two techniques...
February 2018: Electronic Physician
https://www.readbyqxmd.com/read/29604461/assessing-potential-confounding-and-misclassification-bias-when-studying-the-safety-of-the-childhood-immunization-schedule
#12
Matthew F Daley, Jo Ann Shoup, Sophia R Newcomer, Michael L Jackson, Holly C Groom, Steven J Jacobsen, Huong Q McLean, Nicola P Klein, Eric S Weintraub, Michael M McNeil, Jason M Glanz
OBJECTIVES: Some parents are concerned the childhood immunization schedule could increase risk for allergic disorders, including asthma. To inform future safety studies of this speculated association, a parent survey was conducted to: 1) examine risk of misclassification of vaccination status in electronic health record (EHR) data; and 2) assess potential for confounding if asthma risk factors varied by vaccination status. METHODS: A survey was conducted among parents of children 19-35 months old at 6 medical organizations within the Vaccine Safety Datalink...
March 28, 2018: Academic Pediatrics
https://www.readbyqxmd.com/read/29599965/airborne-protein-concentration-a-key-metric-for-type-1-allergy-risk-assessment-in-home-measurement-challenges-and-considerations
#13
Liz Tulum, Zoë Deag, Matthew Brown, Annette Furniss, Lynn Meech, Anja Lalljie, Stella Cochrane
Background: Exposure to airborne proteins can be associated with the development of immediate, IgE-mediated respiratory allergies, with genetic, epigenetic and environmental factors also playing a role in determining the likelihood that sensitisation will be induced. The main objective of this study was to determine whether airborne concentrations of selected common aeroallergens could be quantified in the air of homes using easily deployable, commercially available equipment and analytical methods, at low levels relevant to risk assessment of the potential to develop respiratory allergies...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29590653/misleading-allergens-in-the-diagnosis-of-latex-allergy-profilin-and-cross-reactive-carbohydrate-determinants
#14
Feridun Gürlek, Mehmet Ünsel, Ömür Ardeniz, Zeynep Peker Koc, Okan Gülbahar, Aytül Zerrin Sin, Ali Kokuludag, Nihal Mete Gokmen
BACKGROUND: It has been suggested that latex-specific IgE analysis may lead to false-positive results, especially in patients with pollen allergy. In the present study, the reasons underlying clinically irrelevant latex-specific IgE positivity were investigated. METHODS: Thirty patients with latex allergy (group 1), 89 patients sensitised to aeroallergens (group 2a), and 98 healthy individuals without allergy (group 2b) were enrolled. Participants from all 3 groups were subjected to skin prick tests with aeroallergens including latex, latex-specific IgE analysis (ImmunoCAP), and nasal provocation test with latex...
2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29579655/dynamic-ecological-observations-from-satellites-inform-aerobiology-of-allergenic-grass-pollen
#15
Rakhesh Devadas, Alfredo R Huete, Don Vicendese, Bircan Erbas, Paul J Beggs, Danielle Medek, Simon G Haberle, Rewi M Newnham, Fay H Johnston, Alison K Jaggard, Bradley Campbell, Pamela K Burton, Constance H Katelaris, Ed Newbigin, Michel Thibaudon, Janet M Davies
Allergic diseases, including respiratory conditions of allergic rhinitis (hay fever) and asthma, affect up to 500 million people worldwide. Grass pollen are one major source of aeroallergens globally. Pollen forecast methods are generally site-based and rely on empirical meteorological relationships and/or the use of labour-intensive pollen collection traps that are restricted to sparse sampling locations. The spatial and temporal dynamics of the grass pollen sources themselves, however, have received less attention...
March 23, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29574077/wheat-amylase-trypsin-inhibitors-exacerbate-intestinal-and-airway-allergic-immune-responses-in-humanized-mice
#16
Iris Bellinghausen, Benno Weigmann, Victor Zevallos, Joachim Maxeiner, Sonja Reißig, Ari Waisman, Detlef Schuppan, Joachim Saloga
BACKGROUND: Amylase-trypsin inhibitors (ATIs) in wheat and related cereals are potent activators of myeloid innate immune cells via engagement of TLR4. Furthermore, ATIs have been shown to serve as adjuvants in experimental intestinal inflammatory diseases. OBJECTIVE: The aim of this study was to analyze whether ATIs are also modifiers of allergic inflammation. METHODS: Therefore, CD4+ T cells from grass or birch pollen sensitized donors were stimulated with autologous allergen-pulsed dendritic cells in the presence or absence of ATIs or the control storage protein zein from corn...
March 21, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29572287/allergen-specific-immunotherapy-in-the-treatment-of-pediatric-asthma-a-systematic-review
#17
REVIEW
Jessica L Rice, Gregory B Diette, Catalina Suarez-Cuervo, Emily P Brigham, Sandra Y Lin, Murugappan Ramanathan, Karen A Robinson, Antoine Azar
CONTEXT: Treatment options for allergic asthma include allergen avoidance, pharmacotherapy, and allergen immunotherapy. OBJECTIVES: Summarize and update current evidence for the efficacy and safety of subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) in pediatric allergic asthma. DATA SOURCES: PubMed, Embase, Cochrane Central Register of Controlled Trials (January 1, 2005, through May 8, 2017), ClinicalTrials.gov, and the US Food and Drug Administration Adverse Event Reporting System...
March 23, 2018: Pediatrics
https://www.readbyqxmd.com/read/29563159/-alternaria-sensitisation-at-age-6-years-is-associated-with-subsequent-airway-hyper-responsiveness-in-non-asthmatics
#18
Anunya Hiranrattana, Debra A Stern, Stefano Guerra, Marilyn Halonen, Anne L Wright, Michael Daines, Fernando D Martinez, Wayne J Morgan
In the non-selected birth cohort Tucson Children's Respiratory Study, early sensitisation to Alternaria was associated with increased airway hyper-responsiveness (AHR) into adult life among non-asthmatics. The increase in AHR was of a similar magnitude to that seen for Alternaria sensitised asthmatics and was primarily evident among those who were overweight or obese. In contrast, there was no significant association between early sensitisation to aeroallergens other than Alternaria and AHR among non-asthmatics...
March 21, 2018: Thorax
https://www.readbyqxmd.com/read/29545433/recurrence-of-eosinophilic-oesophagitis-with-subcutaneous-grass-pollen-immunotherapy
#19
Rosy Wells, A T Fox, Mark Furman
Case reports have described an association between oral food/aeroallergen immunotherapy with the development of eosinophilic oesophagitis (EoE). The underlying mechanism of this is poorly understood, as is the role that both food/aeroallergen sensitisation plays in the pathogenesis of EoE. Specific immunotherapy has a long-standing history of use in the management of moderate/severe seasonal allergic rhinitis (AR), caused by tree/grass pollens. Subcutaneous immunotherapy (SCIT) to grass pollen is less commonly used in children than sublingual immunotherapy (SLIT) or oral immunotherapy for practical reasons...
March 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29520147/a-10-year-retrospective-study-of-alterative-aeroallergens-sensitization-spectrum-in-urban-children-with-allergic-rhinitis
#20
Li-Fen Yang, Liang-Ming Cai, Ming Li, Jin-Tao Liu, Zhao-Ni Wang, Wei-Hao Wang, Qin-Tai Yang, Zhuang-Gui Chen
Objective: To investigate the alterative spectrum and trends of aeroallergens sensitization in children with allergic rhinitis (AR) in Guangzhou, China in the past 10 years. Participants and methods: In this retrospective study, 4,111 children with complaints of nasal hyper-reactivity who visited the Pediatric Department and/or Otolaryngology Department from January 2007 to November 2016 were enrolled. Serum specific immunoglobulin E was measured and positive detection was made in 3,328 patients, who were, therefore, diagnosed with AR...
2018: Therapeutics and Clinical Risk Management
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