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https://www.readbyqxmd.com/read/28211191/cigarette-smoking-increases-bronchial-mucosal-il-17a-expression-in-asthmatics-which-acts-in-concert-with-environmental-aeroallergens-to-engender-neutrophilic-inflammation
#1
Leonard Quok Chean Siew, Shih-Ying Wu, Sun Ying, Christopher John Corrigan
BACKGROUND: Mild asthmatics who smoke cigarettes may develop unstable disease and neutrophilic infiltration of the airways, features more usually associated with severe asthmatic disease. The mechanisms giving rise to this response remain unclear. OBJECTIVE: To address the hypothesis that smoking increases bronchial mucosal production of IL-17A which acts on bronchial epithelial cells directly and in concert with other environmental stimuli to induce the production of IL-6 and neutrophil chemotaxins...
February 17, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28208220/allergic-respiratory-disease-different-allergens-different-symptoms
#2
Antonio Valero, Santiago Quirce, Ignacio Dávila, Julio Delgado, Javier Domínguez-Ortega
BACKGROUND: Spanish population is rather homogeneous in its genetic and socio-cultural characteristics, but allergen sensitization shows wide geographical variations. We aimed at assessing whether sensitization to different allergens in the diverse geographical areas induced different clinical and quality of life characteristics in adult patients with a first-time diagnosis of rhinitis and/or asthma. METHODS: Two sequential, identically designed studies were carried out to evaluate such associations (PERFILAR I and II)...
February 16, 2017: Allergy
https://www.readbyqxmd.com/read/28194190/prevalence-of-allergen-sensitization-in-1000-adults-in-saskatchewan
#3
Stacey D Lok, Beth E Davis, Donald W Cockcroft
BACKGROUND: The prevalence of sensitization varies geographically based on multiple environmental factors including humidity. The aim of this study was to determine the prevalence of atopy in symptomatic adults. More importantly we aimed to obtain a regional statistic of sensitization to common allergens given Saskatchewan's dry climate. METHODS: One thousand consecutive symptomatic adults were screened for atopy via skin prick test over 10 years (2006-2016) in the Division of Respirology...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28188710/-prevalence-of-sensitization-to-inhalant-allergens-in-the-immunology-department-from-hospital-de-especialidades-pedi%C3%A3-tricas-mar%C3%A3-a-honduras-2016
#4
Victoria Alejandra Gonzales-González, Adolfo Martín Díaz-Flores, Karla Zobeyda Fernández-Zelaya, María Félix Rivera-Reyes
BACKGROUND: Allergic diseases are a public health problem; estimates indicate that between 30% and 40% of the world population is affected by some allergy. Knowing the prevalence of allergen sensitization allows for adequate diagnoses and treatments to be offered. In Honduras there are no studies available in pediatric patients. OBJECTIVE: The purpose of this research was to identify the most common types of sensitization in children and their correlation with the most common allergic diseases in patients on immunotherapy at the Maria Hospital of Pediatric Specialties...
January 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/28188708/-skin-reactivity-frequency-to-aeroallergens-in-patients-with-clinical-symptoms-of-allergic-disease
#5
Isabel Cristina Rojas-Méndez, Oswaldo Arana-Muñoz, Aída Inés López-García, Daniela Rivero-Yeverino, Chrystopherson Gengyny Caballero-López, Sergio Papaqui-Tapia, Heriberto Camero-Martínez, Elizabeth Vázquez-Rojas
BACKGROUND: Allergic diseases diagnosis must be based on adequate allergological anamnesis and an immunological sensitization test; the most sensitive and specific is the skin prick test. OBJECTIVE: To determine the frequency of skin reactivity to aeroallergens, by age groups, in patients of the Department of Allergy and Clinical Immunology of the Hospital Universitario de Puebla, in Mexico. METHODS: A cross-sectional study was conducted that included patients aged 2 to 64 years with symptoms suggestive of allergic disease, in which skin prick tests with aeroallergens were performed; the diagnostic criteria were those of international guidelines...
January 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/28183432/lessons-learned-from-birth-cohort-studies-conducted-in-diverse-environments
#6
REVIEW
Daniel J Jackson, James E Gern, Robert F Lemanske
Childhood asthma develops from a complex interaction among host and environmental factors in early life. Birth cohort studies have provided valuable insight into asthma risk factors and the natural history of wheezing and asthma through childhood and beyond. Early life aeroallergen sensitization and wheezing illnesses associated with virus and bacterial infections have been identified as pivotal risk factors for asthma inception. Recently, focus has turned toward protective factors that promote lung health in children...
February 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28128470/factors-influencing-serum-concentrations-of-igd-in-the-adult-population-an-observational-study-in-spain
#7
Iago Carballo, Noelia Rabuñal, Lucía Alvela, Luis-Fernando Pérez, Carmen Vidal, Manuela Alonso, Bernardo Sopeña, Francisco Gude, Arturo Gonzalez-Quintela
Immunoglobulin D (IgD) is the least studied of immunoglobulin classes. This study sought to investigate the potential relationship between demographic, metabolic, lifestyle and immunologic factors, and serum IgD concentrations in a general adult population. We measured serum IgD concentrations by means of a commercial turbidimetric assay in 413 individuals (median age, 55 years; 45% males), randomly selected from the adult population of a Spanish municipality. Serum IgD concentrations displayed considerable variation in the population, ranging from undetectable (<6...
January 27, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28124848/the-prevalence-of-grass-pollen-related-allergic-rhinoconjunctivitis-in-elite-amateur-irish-athletes
#8
M Grace, D Hunt, J O'B Hourihane
Allergic rhinoconjunctivitis (AR/C), has been shown to impact upon athletic performance. The championships of the unique, amateur Irish sports of hurling and Gaelic football (collectively known as GAA) take place during the prime pollen months of summer. Elite GAA players must perform optimally when most exposed to pollen. Elite GAA subjects (n=254) underwent skin prick testing to 6 aeroallergens and completed a validated questionnaire (AQUA), producing a score indicating likelihood of having allergy. The prevalence of allergy (positive to at least one aeroallergen on SPT and positive AQUA score) was 27...
September 9, 2016: Irish Medical Journal
https://www.readbyqxmd.com/read/28118241/management-of-preschool-recurrent-wheezing-and-asthma-a-phenotype-based-approach
#9
Avraham Beigelman, Leonard B Bacharier
PURPOSE OF REVIEW: The purpose of this review is to summarize the recent evidence on the management of preschool children with wheezing and asthma, and to propose a phenotype-based approach to the management of these children. RECENT FINDINGS: Recent studies have begun to identify populations of preschool children that are likely to benefit from inhaled corticosteroids (ICS) therapy and defined ICS regimens: daily ICS in preschool children with persistent asthma, and pre-emptive high-dose intermittent ICS among preschool children with intermittent disease reduce the risk of exacerbation...
January 21, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28102718/vitamin-d-status-aeroallergen-sensitization-and-allergic-rhinitis-a-systematic-review-and-meta-analysis
#10
Zahra Aryan, Nima Rezaei, Carlos A Camargo
PURPOSE: The role of vitamin D status in the etiology of allergic diseases is uncertain. The aim of this study was to investigate the association of vitamin D status with risk of two main outcomes: aeroallergen sensitization and allergic rhinitis (AR). METHODS: We performed a systematic review of Medline, Scopus, Science Citation Index, and Google Scholar databases. Studies were included if they reported on prevalent or incident cases of aeroallergen sensitization or AR according to vitamin D status...
January 2, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28076322/aeroallergen-der-p-2-promotes-motility-of-human-non-small-cell-lung-cancer-cells-via-toll-like-receptor-mediated-up-regulation-of-urokinase-type-plasminogen-activator-and-integrin-focal-adhesion-kinase-signaling
#11
Chun-Hsiang Lin, Hui-Han Lin, Cheng-Yi Kuo, Shao-Hsuan Kao
House dust mite (HDM) allergens are one of the major causes leading to respiratory hypersensitiveness and airway remodeling. Here we hypothesized that a major HDM allergen Der p 2 could increase cell motility and invasiveness of non-small cell lung cancer (NSCLC) cells. Our results showed that low dose (1 and 3 μg/mL) recombinant Der p 2 protein (DP2) enhanced the migration and invasiveness of human NSCLC cell A549, H1299 and CL1-5, but nonsignificantly altered their growth. Further investigation revealed that integrin αV level was increased and its downstream signaling including focal adhesion kinase (FAK) and paxillin were activated in A549 cells exposed to DP2...
January 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28073701/effect-of-asthma-therapies-on-the-natural-course-of-asthma
#12
REVIEW
Elissa M Abrams, Stanley J Szefler, Allan B Becker
OBJECTIVE: To provide an evidence-based review on the role of pharmacologic (inhaled corticosteroids, leukotriene receptor antagonists, biologic therapies, aeroallergen immunotherapy) and nonpharmacologic therapies (environmental modifications, microbiome) in secondary and tertiary asthma prevention. DATA SOURCES: A PubMed search for English-language publications regarding asthma and secondary or tertiary prevention was performed. Some articles cited in selected studies were also considered for inclusion in this review...
December 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28049188/association-of-polysensitization-allergic-multimorbidity-and-allergy-severity-a-cross-sectional-study-of-school-children
#13
Eun Kyo Ha, Ji Hyeon Baek, So-Yeon Lee, Yong Mean Park, Woo Kyung Kim, Youn Ho Sheen, Seung Jin Lee, Youngoh Bae, Jihyeon Kim, Kee-Jae Lee, Kangmo Ahn, Ho-Jang Kwon, Man Yong Han
BACKGROUND: Aeroallergen sensitization is related to the coexistence of allergic diseases, but the nature of this relationship is poorly understood. The aim of this study was to clarify the relationship of polysensitization with allergic multimorbidities and the severity of allergic diseases. METHODS: This study is a cross-sectional analysis of 3,368 Korean children aged 6-7 years-old. We defined IgE-mediated allergic diseases based on structured questionnaires, and classified the sensitivity to 18 aeroallergens by logistic regression and the Ward hierarchical clustering method...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28045458/bacteria-isolated-from-lung-modulate-asthma-susceptibility-in-mice
#14
Aude Remot, Delphyne Descamps, Marie-Louise Noordine, Abdelhak Boukadiri, Elliot Mathieu, Véronique Robert, Sabine Riffault, Bart Lambrecht, Philippe Langella, Hamida Hammad, Muriel Thomas
Asthma is a chronic, non-curable, multifactorial disease with increasing incidence in industrial countries. This study evaluates the direct contribution of lung microbial components in allergic asthma in mice. Germ-Free and Specific-Pathogen-Free mice display similar susceptibilities to House Dust Mice-induced allergic asthma, indicating that the absence of bacteria confers no protection or increased risk to aeroallergens. In early life, allergic asthma changes the pattern of lung microbiota, and lung bacteria reciprocally modulate aeroallergen responsiveness...
January 3, 2017: ISME Journal
https://www.readbyqxmd.com/read/28034578/staphylococcus-aureus-enterotoxin-sensitization-involvement-and-its-association-with-the-cysltr1-variant-in-different-asthma-phenotypes
#15
Hisako Matsumoto, Yoshihiro Kanemitsu, Tadao Nagasaki, Yuji Tohda, Takahiko Horiguchi, Hideo Kita, Kazunobu Kuwabara, Keisuke Tomii, Kojiro Otsuka, Masaki Fujimura, Noriyuki Ohkura, Katsuyuki Tomita, Akihito Yokoyama, Hiroshi Ohnishi, Yasutaka Nakano, Tetsuya Oguma, Soichiro Hozawa, Yumi Izuhara, Isao Ito, Tsuyoshi Oguma, Hideki Inoue, Tomoko Tajiri, Toshiyuki Iwata, Junya Ono, Shoichiro Ohta, Tomomitsu Hirota, Takahisa Kawaguchi, Mayumi Tamari, Tetsuji Yokoyama, Yasuharu Tabara, Fumihiko Matsuda, Kenji Izuhara, Akio Niimi, Michiaki Mishima
BACKGROUND: Sensitization to Staphylococcus aureus enterotoxin (SE) is a known risk factor for asthma susceptibility and severity. However, how SE sensitization is involved in asthma, particularly nonatopic asthma and/or late-onset asthma, remains uncertain. OBJECTIVE: To clarify the involvement of SE sensitization in nonatopic and/or late-onset asthma and its association with a polymorphism of the cysteinyl leukotriene receptor 1 gene (CysLTR1), which was examined because CysLT signaling is closely associated with late-onset eosinophilic asthma...
December 26, 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28032359/opisthorchis-felineus-negatively-associates-with-skin-test-reactivity-in-russia-europrevall-inco-study
#16
Olga S Fedorova, Jacqueline J Janse, Ludmila M Ogorodova, Marina M Fedotova, Rogier A Achterberg, Jaco J Verweij, Montserrat Fernández-Rivas, Serge A Versteeg, James Potts, Cosetta Minelli, Ronald van Ree, Peter Burney, Maria Yazdanbakhsh
BACKGROUND: Most studies on the relationship between helminth infections and atopic disorders have been conducted in (sub)tropical developing countries where exposure to multiple parasites and lifestyle can confound the relationship. We aimed to study the relationship between infection with the fish-borne helminth Opishorchis felineus and specific IgE, skin prick testing and atopic symptoms in Western-Siberia, with lifestyle and hygiene standards of a developed country. METHODS: Schoolchildren aged 7 to 11 years were sampled from one urban and two rural regions...
December 29, 2016: Allergy
https://www.readbyqxmd.com/read/28030377/microbes-allergic-sensitization-and-the-natural-history-of-asthma
#17
Halie M Anderson, Daniel J Jackson
PURPOSE OF REVIEW: Understanding factors that lead to asthma development in early life is essential to developing strategies aimed at primary or secondary prevention. RECENT FINDINGS: This article will review current evidence addressing the development of early life allergic sensitization in relation to microbes and the gut and airway microbiome. Wheezing illnesses, particularly viral, remain a significant risk factor for asthma inception; however, bacterial pathogens have recently emerged as an additional important contributor to asthma risk, either alone or as cofactors with viral infections...
December 24, 2016: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28008277/technical-and-clinical-validation-of-an-environmental-exposure-unit-for-ragweed
#18
Paul J Gomes, Keith J Lane, Endri Angjeli, Linda Stein, Mark B Abelson
BACKGROUND: Allergic rhinitis is a common condition, with ragweed pollen one of the more prevalent aeroallergens. Environmental exposure units such as the Allergen BioCube(®) are valuable models for clinical allergy studies. A study was conducted to validate the Allergen BioCube for uniform ragweed pollen concentrations and clinically relevant sign and symptom responses to ragweed exposure. METHODS: Ragweed pollen concentrations were measured on 3 consecutive days in the Allergen BioCube and verified by Rotorod collection and continuous laser particle count measurements...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27996940/allergic-fungal-airway-disease
#19
REVIEW
E M Rick, K Woolnough, C H Pashley, A J Wardlaw
Fungi are ubiquitous and form their own kingdom. Up to 80 genera of fungi have been linked to type I allergic disease, and yet, commercial reagents to test for sensitization are available for relatively few species. In terms of asthma, it is important to distinguish between species unable to grow at body temperature and those that can (thermotolerant) and thereby have the potential to colonize the respiratory tract. The former, which include the commonly studied Alternaria and Cladosporium genera, can act as aeroallergens whose clinical effects are predictably related to exposure levels...
2016: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/27992959/allergic-sensitization-at-school-age-is-a-systemic-low-grade-inflammatory-disorder
#20
B L Chawes, J Stokholm, A-M M Schoos, N R Fink, S Brix, H Bisgaard
BACKGROUND: Systemic low-grade inflammation has been demonstrated in a range of the frequent noncommunicable diseases (NCDs) proposing a shared mechanism, but is largely unexplored in relation to allergic sensitization. We therefore aimed to investigate the possible association with childhood allergic sensitization. METHODS: High-sensitivity C-reactive protein (hs-CRP), interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α), and chemokine (C-X-C motif) ligand 8 (CXCL8) were measured in plasma at age 6 months (N = 214) and 7 years (N = 277) in children from the Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000 ) birth cohort...
December 19, 2016: Allergy
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