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https://www.readbyqxmd.com/read/29345235/news-on-climate-change-air-pollution-and-allergic-trigger-factors-of-asthma
#1
REVIEW
M D Amato, L Cecchi, I Annesi-Maesano, G D Amato
The rising frequency of obstructive respiratory diseases,in particular allergic asthma, observed over the last years, can be partially explained by changes occurring in the environment, with increasing presence in atmosphere of chemical (particulate matter and gaseous components such as nitrogen dioxide and ozone) and biologic (aeroallergens) trigger factors. Aeroallergens are able to stimulate, in allergic subjects, the airways' sensitization, inducing symptoms of bronchial asthma. Over the last 50 years, global earth's temperature has markedly risen likely because of growing emission of anthropogenic greenhouse gas concentrations...
January 17, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29341450/characterization-of-a-novel-papain-inducible-murine-model-of-eosinophilic-rhinosinusitis
#2
Anuj Tharakan, Alex Dobzanski, Nyall R London, Syed M Khalil, Nitya Surya, Andrew P Lane, Murugappan Ramanathan
BACKGROUND: Eosinophilic chronic rhinosinusitis (ECRS) is a disease characterized by eosinophilic inflammatory infiltrate and a local type 2 cytokine milieu. Current animal models fail to recapitulate many of the innate and adaptive immunologic hallmarks of the disease, thus hindering the development of effective therapeutics. In the present study, mice were exposed intranasally to the cysteine protease papain, which shares functional similarities with parasitic proteases and aeroallergens, to generate a rapidly inducible murine model of eosinophilic rhinosinusitis...
January 17, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29339956/csaci-position-statement-prescribing-sublingual-immunotherapy-tablets-for-aeroallergens
#3
REVIEW
J Quirt, R Gagnon, A K Ellis, H L Kim
No abstract text is available yet for this article.
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29338965/quality-of-life-and-clinical-characterization-of-patients-with-vernal-keratoconjunctivitis-in-a-pediatric-population-in-colombia
#4
C M Gómez-Henao, C I Herrera-Morales, R Ramírez-Giraldo, R Cardona-Villa
Vernal keratoconjunctivitis is one of the most serious ocular allergies that have the potential to induce large ocular morbidity and significant visual changes affecting the quality of life of these individuals. METHODOLOGY: This study was conducted in two phases. The first phase consisted of the clinical characterization of 32 patients from the Clinical Allergology center of the I.P.S. Universitaria from July 2014 to February 2015. A retrospective analysis of medical records was performed...
January 12, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29337913/proteomic-analysis-and-identification-of-possible-allergenic-proteins-in-mature-pollen-of-populus-tomentosa
#5
Liuqiang Wang, Xiaoling Zhang, Jin Zhang, Wei Fan, Mengzhu Lu, Jianjun Hu
Pollen grains from Populus tomentosa, a widely cultivated tree in northern area of China, are considered to be an important aeroallergen causing severe allergic diseases. To gain insight into their allergenic components, mature Populus tomentosa pollen proteins were analyzed by two-dimensional gel electrophoresis (2-DE) and matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF/TOF MS). A total of 412 spots from mature pollen were resolved on pH 4-7 immobilized pH gradient (IPG) strips and 159 distinct proteins were identified from 242 spots analyzed...
January 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29332097/is-the-atopy-patch-test-reliable-in-the-evaluation-of-food-allergy-related-atopic-dermatitis
#6
Mahboubeh Mansouri, Elham Rafiee, Sepideh Darougar, Mehrnaz Mesdaghi, Zahra Chavoshzadeh
BACKGROUND: Aeroallergens and food allergens are found to be relevant in atopic dermatitis. The atopy patch test (APT) can help to detect food allergies in children with atopic dermatitis. This study evaluates if the APT is a valuable tool in the diagnostic workup of children with food allergy-related atopic dermatitis. METHODS: 42 children between 6 months and 12 years of age were selected at the Mofid Children Hospital. Atopic dermatitis was diagnosed, and the severity of the disease was determined...
January 13, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29331643/glucagon-like-peptide-1-signaling-inhibits-allergen-induced-lung-il-33-release-and-reduces-group-2-innate-lymphoid-cell-ilc2-cytokine-production-in-vivo
#7
Shinji Toki, Kasia Goleniewska, Sara Reiss, Jian Zhang, Melissa H Bloodworth, Matthew T Stier, Weisong Zhou, Dawn C Newcomb, Lorraine B Ware, Gregg D Stanwood, Aurelio Galli, Kelli L Boyd, Kevin D Niswender, R Stokes Peebles
BACKGROUND: IL-33 is one of the most consistently associated gene candidates for asthma identified by GWAS. Studies in mice and in human cells have confirmed the importance of IL-33 in inducing type-2 cytokine production from both group 2 innate lymphoid cells (ILC2) and Th2 cells. However, there are no pharmacologic agents known to inhibit IL-33 release from airway cells. OBJECTIVE: To determine the effect of glucagon like peptide receptor-1 GLP-1R signaling on aeroallergen-induced airway IL-33 production and release and on innate type-2 airway inflammation...
January 10, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29331026/the-asthma-rhinitis-multimorbidity-is-associated-with-ige-polysensitization-in-adolescents-and-adults
#8
Valérie Siroux, Natalia Ballardini, Marion Soler, Christian Lupinek, Anne Boudier, Isabelle Pin, Jocelyne Just, Rachel Nadif, Josep M Anto, Erik Melen, Rudolf Valenta, Magnus Wickman, Jean Bousquet
BACKGROUND: Children with multimorbid asthma and rhinitis show IgE polysensitization to several allergen sources. This association remain poorly studied in adolescents and adults using defined allergen molecules. We investigated IgE sensitization patterns towards a broad panel of aeroallergen components in adults and adolescents with a focus on individuals with asthma and rhinitis multimorbidity. METHODS: IgE reactivity to 64 microarrayed aeroallergen molecules was determined with the MeDALL-chip in samples from the French EGEA study (n=840, age=40...
January 13, 2018: Allergy
https://www.readbyqxmd.com/read/29315920/percutaneous-prick-test-irritant-threshold-concentrations-for-eight-allergens-in-healthy-nonsedated-dogs-in-the-usa
#9
Matthew J H Carnett, Jon D Plant
BACKGROUND: Percutaneous testing (PT) is preferred to intradermal testing in humans for the in vivo identification of allergen hypersensitivity, but the methodology has not been well described for use in dogs with atopic dermatitis. HYPOTHESIS/OBJECTIVES: To identify the irritant threshold concentrations (ITC) of eight aeroallergens using a commercial prick test device in normal dogs. ANIMALS: Twenty healthy, privately owned dogs. METHODS: Percutaneous testing was performed using the GREER® Pick® System (Stallergenes Greer; Lenoir, NC, USA)...
January 8, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29314322/association-between-pro-inflammatory-alleles-and-allergic-phenotypes-in-xhosa-adolescents
#10
Craig Laurence, Lize van der Merwe, Guicheng Zhang, Peter LeSouëf, Michael Levin
BACKGROUND: Significant differences exist in the prevalence, spectrum and severity of allergic diseases between developing and developed countries and between sub-populations within single countries. These discrepancies likely result from a complex interaction between genetic and environmental factors. However, the precise nature of the contribution of ethnicity to genetic differences in the predisposition to allergic disease is not yet fully understood. In particular, there is a paucity of literature regarding the genetic determinants of allergic disease in people of black African origin with little or no genetic admixture...
January 4, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29284188/repeated-doses-of-salbutamol-and-aeroallergen-sensitisation-both-increased-salbutamol-induced-hypoxia-in-children-and-adolescents-with-acute-asthma
#11
Murat Ozer, Betul Buyuktiryaki, Umit Murat Sahiner, Ozlem Teksam, Betul Karaatmaca, Ozge Soyer, Bulent Enis Sekerel
AIM: We aimed to identify the frequency, magnitude and risk factors of salbutamol-induced hypoxia in children with acute asthma. METHODS: This study was conducted at Hacettepe University on children who presented to the paediatric allergy clinic or the paediatric emergency room with acute asthma between July 2014 and June 2015. Vital signs, pulse oximeter defined oxygen saturation and modified pulmonary index scores were evaluated before and after the first, second and third doses of nebulised salbutamol and repeated one and 10 days later...
December 28, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29283260/targeting-acidic-mammalian-chitinase-is-effective-in-animal-model-of-asthma
#12
Marzena Mazur, Jacek Olczak, Sylwia Olejniczak, Robert Koralewski, Wojciech Czestkowski, Anna Jedrzejczak, Jakub Golab, Karolina Dzwonek, Barbara Dymek, Piotr L Sklepkiewicz, Agnieszka Zagozdzon, Tom Noonan, Keyvan Mahboubi, Bruce Conway, Ryan Sheeler, Paul Beckett, William M Hungerford, Alberto D Podjarny, Andre Mitschler, Alexandra Cousido-Siah, Firas Fadel, Adam Golebiowski
This article highlights our work toward the identification of a potent, selective, and in vivo efficacious acidic mammalian chitinase (AMCase) inhibitor. Rational design, guided by X-ray analysis of several inhibitors bound to human chitotriosidase (hCHIT1) led to the identification of compound 7f as a highly potent, AMCase inhibitor (IC50 values of 14 and 19 nM against human and mouse enzyme, respectively) and selective (>150x against mCHIT1) with very good PK properties. This compound dosed once daily at 30 mg/kg p...
December 28, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29281052/mite-fauna-assessment-in-houses-of-two-distinct-socioeconomic-groups-from-southern-brazil
#13
Moisés S Dutra, Cristian Roncada, Guilherme L da Silva, Noeli J Ferla, Paulo M Pitrez
House dust mites (HDM) are the main source of aeroallergens worldwide, yet epidemiological differences between socioeconomic factors in association with this medical condition have not been studied in the south region of Brazil. To assess the prevalence of HDM in two socioeconomically distinct populations of patients with allergic asthma or rhinitis, the differences between samples from houses of high-income families and low-income families were analyzed. Mite samples were collected between July and December 2015, in Porto Alegre, Brazil...
December 21, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29273134/reliability-of-allergy-skin-testing
#14
Maria Shtessel, Jody Tversky
BACKGROUND: Percutaneous allergen skin testing remains an established benchmark for diagnosing atopic disease. The reliability of skin testing depends greatly on the performance of allergen extracts used, methods used, and the presence of antihistamine medications. OBJECTIVE: To determine the differential effect of cetirizine on 2 different concentrations of histamine control solution and 5 common allergens used for percutaneous skin testing. METHODS: Twelve individuals underwent skin testing with histamine (1 and 6 mg/mL), control diluent, and 5 common aeroallergens...
January 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29244204/respiratory-viral-infections-and-atopic-development-from-possible-mechanisms-to-advances-in-treatment
#15
REVIEW
Lisa M Martorano, Mitchell H Grayson
Atopic sensitization and allergic diseases are increasing in modernized countries. These diseases affect millions of individuals, but the mechanisms behind their development are not fully understood. One hypothesis relates to early life respiratory viral infections driving the development of atopic disease including asthma. This review presents the current state of the field, focusing on epidemiologic data supporting a role for early life respiratory viruses in the development of specific IgE, both against aeroallergens and the respiratory virus...
December 15, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29227043/the-association-of-air-pollutants-and-allergic-and-nonallergic-rhinitis-in-chronic-rhinosinusitis
#16
Leila J Mady, Hannah L Schwarzbach, John A Moore, Robert M Boudreau, Thomas M Kaffenberger, Thomas J Willson, Stella E Lee
BACKGROUND: There has been little investigation regarding air quality and rhinitis in the pathophysiology of upper airway disease. In this study, we assessed the impact of inhalant pollutants (particulate matter 2.5 [PM2.5 ] and black carbon [BC]) on allergic rhinitis and chronic rhinosinusitis (CRS) disease severity. METHODS: CRS patients with nasal polyps (CRSwNP) and without polyps (CRSsNP) were identified. Spatial modeling from pollutant monitoring sites was used to estimate exposures for patients meeting the inclusion criteria (total, n = 125; CRSsNP, n = 67; CRSsNP, n = 58)...
December 11, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29223148/exhaled-nitric-oxide-helps-discriminating-asthmatic-children-with-and-without-positive-specific-ige-to-aeroallergens
#17
Li-Ching Fang, Shyh-Dar Shyur, Jun Yang, Jen-Yu Wang, Yu-Hsuan Kao, Chien-Hui Yang, Yu-Ting Yu
BACKGROUND: Aeroallergen sensitization may predict higher fractional exhaled nitric oxide (FeNO) levels. OBJECTIVE: We evaluate cut-off values of FeNO in asthmatic children with and without positive specific immunoglobulin E (IgE) to at least one of 5 aeroallergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat, dog, and cockroach). METHODS: 564 patients with asthma and allergic rhinitis (AR) aged 5 to 18 years were enrolled into two groups...
December 10, 2018: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/29221817/polyunsaturated-fatty-acids-in-plasma-at-8%C3%A2-years-and-subsequent-allergic-disease
#18
Jessica Magnusson, Sandra Ekström, Inger Kull, Niclas Håkansson, Sara Nilsson, Magnus Wickman, Erik Melén, Ulf Risérus, Anna Bergström
BACKGROUND: Polyunsaturated fatty acids (PUFAs) are hypothesized to modulate the risk of allergic disease. However, evidence from previous studies is inconclusive, and limited longitudinal data exist using circulating biomarkers of PUFA intake and metabolism. OBJECTIVE: We aimed to investigate associations between n-3 and n-6 PUFAs at age 8 years and asthma, rhinitis, and aeroallergen sensitization at age 16 years. METHODS: Proportions of n-3 PUFAs (very long-chain n-3 [VLC n-3; sum of eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid] and α-linolenic acid) and n-6 PUFAs (linoleic acid and arachidonic acid [AA]) in blood samples at age 8 years were measured for 940 children from the prospective Swedish birth cohort BAMSE (Children, Allergy, Milieu, Stockholm, Epidemiology)...
November 29, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29209493/comparison-of-atopy-patch-testing-to-skin-prick-testing-for-diagnosing-mite-induced-atopic-dermatitis-a-systematic-review-and-meta-analysis
#19
REVIEW
Yumei Liu, Jianglong Peng, Ying Zhou, Yubao Cui
Background: Atopic dermatitis (AD) can occur after contact with aeroallergens like house dust mites, pollen, and animal dander. Despite its controversial diagnostic value, the atopy patch test (APT) has been used as an important tool in the diagnosis of AD caused by house dust mites. Here, we present a meta-analysis comparing APT to the common skin prick test (SPT) in the diagnosis of mite-induced AD. Methods: A structured search was performed using online databases and bibliographies published as of April 30, 2017...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29171402/a-short-period-of-breast-feeding-in-infancy-excessive-house-cleaning-absence-of-older-sibling-and-passive-smoking-are-related-to-more-severe-atopic-dermatitis-in-children
#20
Maria Fotopoulou, Maria Iordanidou, Eleni Vasileiou, Grigorios Trypsianis, Athanasios Chatzimichael, Emmanouil Paraskakis
BACKGROUND: Atopic dermatitis (AD) is one of the most common, chronic or chronically relapsing inflammatory skin diseases that affect children. Multiple genetic and environmental factors appear to regulate the pathogenesis of AD. OBJECTIVES: Our aim was to investigate the possible association between family, social, dieting, atopic and environmental factors and the severity of AD evaluated by SCORAD scores in children. MATERIALS & METHODS: The study group included 100 children with AD who attended a paediatric dermatology outpatient clinic with a median age of 18...
November 24, 2017: European Journal of Dermatology: EJD
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