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https://www.readbyqxmd.com/read/27910804/sudden-cardiac-death-a-nationwide-cohort-study-among-the-young
#1
Bjarke Risgaard
Sudden cardiac death (SCD) is a tragic event affecting millions of individuals worldwide. Although several studies have investigated the epidemiology of SCD, these studies may have been affected by reporting and referral biases, which are reflected in the very different incidence rates and causes of deaths that have previously been reported. Among SCD victims aged < 36 years, inherited cardiac diseases are well known to play an important role. However, the extent to which inherited cardiac diseases also play a role in SCD victims aged < 50 years has not been completely described...
December 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27882006/framingham-risk-score-in-impaired-glucose-tolerant-population-a-sub-analysis-of-diabetes-prevention-and-awareness-program-of-pakistan
#2
Asher Fawwad, Hassan Moin, Iftikhar Ahmed Siddiqui, Muhammad Zafar Iqbal Hydrie, Abdul Basit
OBJECTIVE: To assess the 10-year risk of coronary artery disease (CAD) in subjects with impaired glucose tolerance (IGT) using Framingham risk score. METHODS: Data for this study was collected from Diabetes Prevention and Awareness Program. Primary prevention team visited different primary health care centers, factories, service organizations and offices within Karachi, Pakistan. IGT was diagnosed according to World Health Organization criteria after taking informed consent...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27875636/evaluation-of-coronary-artery-disease-in-potential-liver-transplant-recipients
#3
REVIEW
Brian J Hogan, Enoka Gonsalkorala, Michael A Heneghan
Improvements in the management of patients undergoing Liver Transplantation (LT) have resulted in a significant increase in survival over recent years. Cardiac disease is now the leading cause of early mortality and the stress of major surgery, haemodynamic shifts, the possibility of haemorrhage or reperfusion syndrome require the recipient to have good baseline cardiac function. The prevalence of coronary artery disease (CAD) is increasing in liver transplant candidates, especially in those with Non-Alcohol related Fatty Liver Disease (NAFLD)...
November 22, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27815829/genetics-current-and-future-role-in-the-prevention-and-management-of-coronary-artery-disease
#4
REVIEW
Robert Roberts
PURPOSE OF REVIEW: The purpose of this study is to review genetic risk variants for coronary artery disease (CAD) and how they will change the management and prevention of CAD currently and in the future. RECENT FINDINGS: Through the efforts of international consortia, 58 genetic risk variants for CAD of genome-wide significance have been replicated in appropriate independent populations. Only one third of these variants mediate their risk through known conventional risk factors for CAD...
December 2016: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/27798792/bleeding-risk-associated-with-eptifibatide-integrilin-bridging-in-thoracic-surgery-patients
#5
Nathan H Waldron, Torijaun Dallas, Loretta Erhunmwunsee, Tracy Y Wang, Mark F Berry, Ian J Welsby
Antiplatelet use for treatment of coronary artery disease (CAD) is common amongst thoracic surgery patients. Perioperative management of antiplatelet agents requires balancing the opposing risks of myocardial ischemia and excessive bleeding. Perioperative bridging with short-acting intravenous antiplatelet agents has shown promise in preventing myocardial ischemia, but may increase bleeding. We sought to determine whether perioperative bridging with eptifibatide increased bleeding associated with thoracic surgery...
October 31, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27798731/impact-of-combined-lipid-lowering-and-blood-pressure-control-on-coronary-plaque-myocardial-ischemia-treated-by-percutaneous-coronary-intervention-and-plaque-regression-by-lipid-lowering-and-blood-pressure-controlling-assessed-by-intravascular-ultrasonography
#6
Masa-Aki Kawashiri, Kenji Sakata, Kenshi Hayashi, Tadatsugu Gamou, Honin Kanaya, Kenji Miwa, Kosei Ueda, Toshinori Higashikata, Sumio Mizuno, Ichiro Michishita, Masanobu Namura, Yutaka Nitta, Shoji Katsuda, Kazuyasu Okeie, Hiroaki Hirase, Hayato Tada, Katsuharu Uchiyama, Tetsuo Konno, Hidekazu Ino, Keisuke Nagase, Masakazu Yamagishi
The aim of the study was to elucidate the aggressive reduction of both low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) reduced coronary atherosclerotic plaque volume compared with a standard treatment of LDL-C and BP in Japanese patients with coronary artery disease (CAD). This study is a prospective, randomized, and open-labelled with a blind-endpoint evaluation study. A total of 97 patients (81 men, mean age 62.0 ± 9.6) with CAD undergoing intravascular ultrasonography (IVUS)-guided percutaneous coronary intervention (PCI) were randomized, and 68 patients had IVUS examinations at baseline and at 18-24 months follow-up...
October 31, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/27696319/coronary-computed-tomography-angiography-for-screening-in-patients-with-diabetes-can-enhanced-detection-of-subclinical-coronary-atherosclerosis-improve-outcome
#7
Joseph Brent Muhlestein, Fidela Ll Moreno
PURPOSE OF REVIEW: It is well known that there is a very high risk of cardiovascular complications among diabetic patients. In spite of all efforts at aggressive control of diabetes and its complications, the incidence of cardiovascular morbidity and mortality remains high, including in patients with no prior symptoms, underscoring a possible advantage for appropriate screening of asymptomatic patients for the presence of obstructive coronary artery disease (CAD). In this article, we sought primarily to review the results of studies designed to evaluate a possible role of coronary computed tomography angiography (CCTA) in the screening of asymptomatic diabetic patients for possible obstructive CAD...
November 2016: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/27585501/medical-treatment-and-revascularization-options-in-patients-with-type-2-diabetes-and-coronary-disease
#8
G B John Mancini, Michael E Farkouh, Maria M Brooks, Bernard R Chaitman, William E Boden, Helen Vlachos, Pamela M Hartigan, Flora S Siami, Mandeep S Sidhu, Vera Bittner, Robert Frye, Valentin Fuster
BACKGROUND: There are scant outcomes data in patients with type 2 diabetes and stable coronary artery disease (CAD) stratified by detailed angiographic burden of CAD or left ventricular ejection fraction (LVEF). OBJECTIVES: This study determined the effect of optimal medical therapy (OMT), with or without percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG), on long-term outcomes with respect to LVEF and number of diseased vessels, including proximal left anterior descending artery involvement...
September 6, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27576310/protocol-for-a-randomized-controlled-trial-to-compare-bone-loading-exercises-with-risedronate-for-preventing-bone-loss-in-osteopenic-postmenopausal-women
#9
Laura D Bilek, Nancy L Waltman, Joan M Lappe, Kevin A Kupzyk, Lynn R Mack, Diane M Cullen, Kris Berg, Meghan Langel, Melissa Meisinger, Ashlee Portelli-Trinidad, Molly Lang
BACKGROUND: In the United States, over 34 million American post-menopausal women have low bone mass (osteopenia) which increases their risk of osteoporosis and fractures. Calcium, vitamin D and exercise are recommended for prevention of osteoporosis, and bisphosphonates (BPs) are prescribed in women with osteoporosis. BPs may also be prescribed for women with low bone mass, but are more controversial due to the potential for adverse effects with long-term use. A bone loading exercise program (high-impact weight bearing and resistance training) promotes bone strength by preserving bone mineral density (BMD), improving bone structure, and by promoting bone formation at sites of mechanical stress...
August 30, 2016: BMC Women's Health
https://www.readbyqxmd.com/read/27539884/haptoglobin-2-2-genotype-and-the-risk-of-coronary-artery-disease-in-the-diabetes-control-and-complications-trial-epidemiology-of-diabetes-interventions-and-complications-study-dcct-edic
#10
Trevor J Orchard, Jye-Yu C Backlund, Tina Costacou, Patricia Cleary, Maria Lopes-Virella, Andrew P Levy, John M Lachin
AIMS/HYPOTHESIS: Haptoglobin(Hp) 2-2 genotype has been shown to increase coronary artery disease (CAD) risk in numerous type 2 diabetes studies but in only one type 1 diabetes cohort. We assessed the association of Hp2-2 with incident CAD over 26years of follow-up in 1303 Caucasian participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. METHODS: DCCT randomized volunteers with type 1 diabetes to intensive versus conventional therapy within two cohorts: 'primary prevention' with 1-5years diabetes duration and 'secondary intervention' with 1-15years diabetes duration and early retinopathy, with or without albuminuria, but no advanced complications...
November 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27537556/beneficial-effects-through-aggressive-coronary-screening-for-type-2-diabetes-patients-with-advanced-vascular-complications
#11
Tetsuro Tsujimoto, Takehiro Sugiyama, Ritsuko Yamamoto-Honda, Miyako Kishimoto, Hiroshi Noto, Miyako Morooka, Kazuo Kubota, Munehiro Kamimura, Hisao Hara, Hiroshi Kajio, Masafumi Kakei, Mitsuhiko Noda
Glycemic control alone does not reduce cardiovascular events in patients with type 2 diabetes (T2D), and routine screening of all T2D patients for asymptomatic coronary artery disease (CAD) is not effective for preventing acute cardiac events. We examined the effectiveness of an aggressive screening protocol for asymptomatic CAD in T2D patients with advanced vascular complications.We designed a 3-year cohort study investigating the effectiveness of the aggressive coronary screening for T2D patients with advanced vascular complications and no known coronary events using propensity score adjusted analysis at a national center in Japan...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27504330/a-therapeutic-effects-of-atorvastatin-on-genetic-damage-in-coronary-artery-disease
#12
Kishore Kumar Gundapaneni, Nivas Shyamala, Rajesh Kumar Galimudi, Sanjib Kumar Sahu, Surekha Rani Hanumanth
INTRODUCTION: Coronary Artery Disease (CAD) a multifactorial chronic heart disease and the most frequent cause of death and disabling symptoms worldwide, occurs due to the formation of atheromatous lipid rich plaques in the arteries. Statins, which inhibit cholesterol biosynthesis, have both pleiotropic and Low-Density Lipoprotein (LDL)-lowering properties. Atorvastatin is one of the choices for the primary and secondary prevention of cardiovascular disease and management of hypercholesterolaemia...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27488764/nitrates-for-the-prevention-of-cardiac-morbidity-and-mortality-in-patients-undergoing-non-cardiac-surgery
#13
REVIEW
Na Zhao, Jin Xu, Balwinder Singh, Xuerong Yu, Taixiang Wu, Yuguang Huang
BACKGROUND: Cardiac complications are not uncommon in patients undergoing non-cardiac surgery, especially in patients with coronary artery disease (CAD) or at high risk of CAD. Perioperative cardiac complications can lead to mortality and morbidity, as well as higher costs for patient care. Nitrates, which are among the most commonly used cardiovascular drugs, perform the function of decreasing cardiac preload while improving cardiac blood perfusion. Sometimes, nitrates are administered to patients undergoing non-cardiac surgery to reduce the incidence of cardiac complications, especially for patients with CAD...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27437273/knowledge-and-awareness-of-familial-hypercholesterolaemia-among-registered-medical-practitioners-in-tamil-nadu-are-they-suboptimal
#14
Nandhini Rangarajan, Shanthi Balasubramanian, Jing Pang, Gerald F Watts
INTRODUCTION: Familial Hypercholesterolaemia (FH) is the most common monogenic disorder causing premature Coronary Artery Disease (CAD). However, the majority of people with FH are undiagnosed and under treated. AIM: To determine awareness, knowledge and practices of registered medical practitioners regarding FH in India. MATERIALS AND METHODS: Physicians from a southern state of India (Tamil Nadu) who see the general cases were requested to complete a structured online survey questionnaire based on the outcomes on screening, diagnostic and service aspects of FH...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27431761/association-between-body-mass-index-and-age-of-presentation-with-symptomatic-coronary-artery-disease
#15
Syed M Atique, Bruce Shadbolt, Paul Marley, Ahmad Farshid
BACKGROUND: Obesity is increasingly recognized as an important risk factor for coronary artery disease (CAD). HYPOTHESIS: Patients with increased body mass index (BMI) present at a younger age with symptomatic CAD. METHODS: We analyzed data on 2137 consecutive patients admitted for treatment of CAD proven on angiography from 2010 to 2013, excluding those with prior coronary intervention or bypass surgery. RESULTS: Mean age was 64...
July 19, 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/27390938/culprit-lesion-only-versus-complete-multivessel-percutaneous-intervention-in-st-elevation-myocardial-infarction-a-systematic-review-and-meta-analysis-of-randomized-trials
#16
Pedro A Villablanca, David F Briceno, Daniele Massera, Ota Hlinomaz, Marissa Lombardo, Anna E Bortnick, Mark A Menegus, Robert T Pyo, Mario J Garcia, Farouk Mookadam, Harish Ramakrishna, Jose Wiley, Michela Faggioni, George D Dangas
BACKGROUND: ST-segment elevation myocardial infarction (STEMI) in patients with concomitant multivessel (MV) coronary artery disease (CAD) is associated with poor outcomes. Percutaneous coronary intervention (PCI) of the culprit-lesion only (CLO) as compared with a MV PCI approach to revascularization remains uncertain. Our objective is to gain a better understanding of the efficacy and safety of CLO as compared with MV PCI in patients with STEMI by conducting an updated meta-analysis...
October 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27383534/pneumonia-and-influenza-hospitalizations-among-children-under-5-years-of-age-in-suzhou-china-2005-2011
#17
Xiyan Zhang, Jun Zhang, Liling Chen, Luzhao Feng, Hongjie Yu, Genming Zhao, Tao Zhang
BACKGROUND: The disease burden of influenza among children in China has not been well described. OBJECTIVE: To estimate the influenza-associated excess hospitalization rate and compare the hospitalization length and costs between pneumonia and influenza (P&I) and other community-acquired diseases (CAD) in Suzhou, China. METHODS: We retrospectively collected hospital discharge data on pediatric patients' discharge diagnosis, hospital costs and length of hospital stay in Suzhou...
July 6, 2016: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/27382201/circulating-thrombotic-risk-factors-in-young-patients-with-coronary-artery-disease-who-are-on-statins-and-anti-platelet-drugs
#18
Reema George, Harikrishnan Sivadasanpillai, Narayani Jayakumari, Anugya Bhatt, Jissa V Thulaseedharan, Jaganmohan A Tharakan
Thrombotic risk factors may contribute to premature coronary artery disease (CAD), in addition to the conventional risk factors. There is paucity of data on studies evaluating the role of thrombotic factors in premature CAD in Indian patients. Thus a case-control study was performed to evaluate the role of thrombotic and atherogenic factors in young patients with angiographically proven CAD who are on treatment with statins and anti-platelet drugs. 152 patients (≤55 years) with angiographically proven CAD and 102 asymptomatic controls were recruited...
July 2016: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/27295083/effect-of-statin-therapy-on-mortality-in-older-adults-hospitalized-with-coronary-artery-disease-a-propensity-adjusted-analysis
#19
Daniel P Rothschild, Eric Novak, Michael W Rich
OBJECTIVES: To examine the effect of statins on long-term mortality in older adults hospitalized with coronary artery disease (CAD). DESIGN: Retrospective analysis. SETTING: University teaching hospital. PARTICIPANTS: Individuals aged 80 and older (mean aged 85.2, 56% female) hospitalized from January 2006 to December 2010 with acute myocardial infarction (AMI), unstable angina pectoris, or chronic CAD and discharged alive (N = 1,262)...
July 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27292052/can-we-identify-termination-of-resuscitation-criteria-in-cardiac-arrest-due-to-drowning-results-from-the-french-national-out-of-hospital-cardiac-arrest-registry
#20
Hervé Hubert, Joséphine Escutnaire, Pierre Michelet, Evgéniya Babykina, Carlos El Khoury, Karim Tazarourte, Christian Vilhelm, Lahcen El Hiki, Benjamin Guinhouya, Pierre-Yves Gueugniaud
RATIONALE, AIMS AND OBJECTIVES: The aim of this study was to describe the cohort of persons having experiences fatal and non-fatal drowning events, registered in the French cardiac arrest registry and to identify termination of resuscitation criteria. METHODS: We performed a prospective multicenter study based on data from French cardiac arrest registry database. All patients with cardiac arrest after drowning (CAD) recorded between July 2011 and November 2014 were included...
December 2016: Journal of Evaluation in Clinical Practice
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