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Primary Prevention CAD

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https://www.readbyqxmd.com/read/28545400/the-role-of-a-behavioural-medicine-intervention-in-physiotherapy-for-the-effects-of-rehabilitation-outcomes-in-exercise-based-cardiac-rehabilitation-ecra-the-study-protocol-of-a-randomised-controlled-trial
#1
Sabina Borg, Birgitta Öberg, Lennart Nilsson, Anne Söderlund, Maria Bäck
BACKGROUND: To help patients with coronary artery disease (CAD) benefit from the positive health effects attained by exercise-based cardiac rehabilitation (CR), adherence to these programmes according to international guidelines is important. Strategies to increase adherence to exercise-based CR are mainly an unexplored area. The objective of this study is to investigate the effects of a behavioural medicine intervention in physiotherapy, containing goal-setting, self-monitoring and feedback, with the aim of improving rehabilitation outcomes for exercise-based CR, compared with usual care...
May 25, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28532406/the-addition-of-vildagliptin-to-metformin-prevents-the-elevation-of-interleukin-1%C3%A3-in-patients-with-type-2-diabetes-and-coronary-artery-disease-a-prospective-randomized-open-label-study
#2
Arwa Younis, Dana Eskenazi, Ronen Goldkorn, Jonathan Leor, Nili Naftali-Shani, Enrique Z Fisman, Alexander Tenenbaum, Ilan Goldenberg, Robert Klempfner
BACKGROUND: Patients with type 2 diabetes present with an accelerated atherosclerotic process. Animal evidence indicates that dipeptidyl peptidase-4 inhibitors (gliptins) have anti-inflammatory and anti-atherosclerotic effects, yet clinical data are scarcely available. DESIGN AND METHODS: A prospective, randomized, open-label study was performed in 60 patients with coronary artery disease (CAD) and type 2 diabetes, who participated in a cardiac rehabilitation program...
May 22, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28487302/prophylactic-use-of-eculizumab-during-surgery-in-chronic-cold-agglutinin-disease
#3
Eirik Tjønnfjord, Øystein A Vengen, Sigbjørn Berentsen, Geir Erland Tjønnfjord
Primary chronic cold agglutinin disease (CAD) is an autoimmune haemolytic anaemia in which a specific bone marrow lymphoproliferative disorder causes production of cold agglutinins (CA). Binding of CA to erythrocyte surface antigens results in a predominantly extravascular haemolysis that is entirely complement dependent. Because of complement activation, exacerbations are common during febrile infections, trauma or major surgery. Involvement of the terminal complement pathway with C5-mediated intravascular haemolysis is probably not prominent in stable disease but is supposed to be of importance in exacerbations following acute phase reaction...
May 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28462120/high-density-lipoprotein-cholesterol-hdl-c-in-cardiovascular-disease-effect-of-exercise-training
#4
REVIEW
Nayoung Ahn, Kijin Kim
Decreases in high-density lipoprotein cholesterol (HDL-C) levels are associated with an increased risk of coronary artery disease (CAD), whereas increased HDL-C levels are related to a decreased risk of CAD and myocardial infarction. Although HDL prevents the oxidation of low-density lipoprotein under normal conditions, it triggers a structural change, inhibiting antiarteriosclerotic and anti-inflammatory functions, under pathological conditions such as oxidative stress, inflammation, and diabetes. HDL can transform into various structures based on the quantitative reduction and deformation of apolipoprotein A1 and is the primary cause of increased levels of dysfunctional HDL, which can lead to an increased risk of CAD...
September 2016: Integrative medicine research
https://www.readbyqxmd.com/read/28435446/cardiovascular-risk-assessment-in-patients-with-diabetes
#5
REVIEW
Marcello Casaccia Bertoluci, Viviane Zorzanelli Rocha
Although patients with diabetes have 2 to 4 times increased risk of cardiovascular morbidity and mortality than individuals without diabetes, recent studies indicate that a significant part of patients are in a lower cardiovascular risk category. Men younger than 35 years, women younger than 45 years, patients with diabetes duration of less than 10 years without other risk factors have a much lower risk than patients who have traditional cardiovascular risk factors, and subclinical or established coronary artery disease (CAD)...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28430669/low-previous-cardiovascular-risk-of-patients-with-st-elevation-myocardial-infarction
#6
Gustavo Rodrigues, Pedro de Araújo Gonçalves, Francisco Moscoso Costa, Rui Campante Teles, Dores Hélder, Luís Mariano, João Brito, Henrique Mesquita Gabriel, Manuel Almeida, Miguel Mendes
BACKGROUND: Myocardial infarction is frequently the initial form of presentation of coronary artery disease (CAD). Systemic Coronary Risk Estimation (SCORE) risk tables are used in primary prevention and provide an estimate of cardiovascular (CV) risk through known risk factors. The aim of this study was to evaluate the performance of the SCORE, calculated using data previous to the event, to estimate CV risk of a population of patients presenting with ST-elevation myocardial infarction (STEMI) as the first manifestation of CAD...
April 20, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28414761/identification-of-a-plasma-metabolomic-signature-of-thrombotic-myocardial-infarction-that-is-distinct-from-non-thrombotic-myocardial-infarction-and-stable-coronary-artery-disease
#7
Andrew P DeFilippis, Patrick J Trainor, Bradford G Hill, Alok R Amraotkar, Shesh N Rai, Glenn A Hirsch, Eric C Rouchka, Aruni Bhatnagar
AIMS: Current non-invasive diagnostics for acute myocardial infarction (MI) identify myocardial necrosis rather than the primary cause and therapeutic target-plaque disruption and resultant thrombosis. The aim of this study was to identify changes specific to plaque disruption and pathological thrombosis that are distinct from acute myocardial necrosis. METHODS AND RESULTS: We quantified 1,032 plasma metabolites by mass spectrometry in 11 thrombotic MI, 12 non-thrombotic MI, and 15 stable coronary artery disease (CAD) subjects at two acute phase (time of catheterization [T0], six hours [T6]) and one quiescent (>3 months follow-up) time points...
2017: PloS One
https://www.readbyqxmd.com/read/28384989/application-of-cad-cam-for-fabrication-of-metal-free-band-and-loop-space-maintainer
#8
Harleen Kaur Soni
An ideal occlusion with proper tooth alignment and fully functional teeth is the ultimate goal of all dental treatments. Premature extraction of deciduous teeth is a common sequeale of untreated dental caries in teeth in which the damage is far beyond repair. Premature extraction might lead to loss of space for the successor tooth, drifting of teeth and loss of arch integrity leading to malocclusion in the permanent teeth. To prevent the space loss, space maintainers are designed and delivered at the time of extraction to allow for development of proper functional occlusion in children till the eruption of the succedaneous permanent tooth...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28176521/withdrawal-implantable-cardioverter-defibrillators-for-primary-prevention-in-patients-with-nonischemic-cardiomyopathy-a-systematic-review-and-meta-analysis
#9
Tamer Akel, James Lafferty
The article by Akel T., Lafferty J. entitled "IMPLANTABLE CARDIOVERTER DEFIBRILLATORS FOR PRIMARY PREVENTION IN PATIENTS WITH NONISCHEMIC CARDIOMYOPATHY: A SYSTEMATIC REVIEW AND META-ANALYSIS" was published ahead of print in the journal Minerva Cardioangiologica on February 8, 2017. The corresponding author of the article, Dr. Tamel, and his group submitted the same manuscript to two different journal simultaneously (Minerva Cardioangiologica - Edizioni Minerva Medica and Cardiovascular therapeutics - Wiley on December 8, 2016), despite a properly handsigned copyright form stating the paper had not been submitted to any other journals was provided, with subsequent redundant publications...
February 8, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28143388/effects-of-cardiac-telerehabilitation-in-patients-with-coronary-artery-disease-using-a-personalised-patient-centred-web-application-protocol-for-the-smartcare-cad-randomised-controlled-trial
#10
Rutger W M Brouwers, Jos J Kraal, Simone C J Traa, Ruud F Spee, Laurence M L C Oostveen, Hareld M C Kemps
BACKGROUND: Cardiac rehabilitation has beneficial effects on morbidity and mortality in patients with coronary artery disease, but is vastly underutilised and short-term improvements are often not sustained. Telerehabilitation has the potential to overcome these barriers, but its superiority has not been convincingly demonstrated yet. This may be due to insufficient focus on behavioural change and development of patients' self-management skills. Moreover, potentially beneficial communication methods, such as internet and video consultation, are rarely used...
January 31, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28129469/implantable-cardioverter-defibrillators-for-primary-prevention-in-patients-with-nonischemic-cardiomyopathy-a-systematic-review-and-meta-analysis
#11
Tamer Akel, James Lafferty
BACKGROUND: Implantable cardioverter defibrillators (ICDs) have proved their benefit in exerting favorable outcomes on survival in selected patients with cardiomyopathy. Although previous meta-analyses have shown benefit for their use in primary prevention, the evidence is less robust for patients with NICM in comparison to patients with CAD. OBJECTIVES: To evaluate the ability of ICD therapy in reducing all-cause mortality and sudden cardiac death (SCD) in patients with NICM...
January 27, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28070240/newer-perspectives-of-coronary-artery-disease-in-young
#12
REVIEW
Amitesh Aggarwal, Saurabh Srivastava, M Velmurugan
Coronary artery disease (CAD) occurring in less than 45 years of age is termed as young CAD. Recent studies show a prevalence of 1.2% of CAD cases in this age group. Ethnic wise south Asians especially Indians are more vulnerable to have CAD in young age group with a prevalence of 5% to 10%. Conventional risk factors such as smoking, diabetes, hypertension, obesity and family history seems to be as important as in older CAD subjects. But the prevalence of these risk factors seems to vary in younger subjects...
December 26, 2016: World Journal of Cardiology
https://www.readbyqxmd.com/read/28042727/new-evidence-for-cardiac-benefit-of-postmenopausal-hormone-therapy
#13
REVIEW
T S Mikkola, H Savolainen-Peltonen, M Venetkoski, O Ylikorkala
Coronary artery disease (CAD) is still the most common killer of western women. Coronary arteries, expressing estrogen receptors, are a target for estrogen action. Prior to the Women's Health Initiative (WHI) study, postmenopausal hormone therapy (HT) was widely advocated for primary prevention of CAD, but such use was criticized after the WHI publication. However, new data accumulated in the USA and in Europe indicate that the use of estradiol-based HT regimens does not endanger the heart, but rather, it significantly reduces the incidence of CAD events and mortality...
February 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/27928736/antiplatelet-agents-in-hemodialysis
#14
REVIEW
Massimiliano Migliori, Vincenzo Cantaluppi, Alessia Scatena, Vincenzo Panichi
Patients affected by cardiovascular disease (CVD) are treated with antiplatelet agents (AA) and/or anticoagulant drugs, which are fundamental in the management of stroke, coronary atherosclerotic disease, peripheral vascular disease and atrial fibrillation. CVD is the most important cause of death in chronic renal failure (CRF). Death rates from myocardial infarction (MI) and from all other cardiac causes exceed those for the general population. Incidence of MI in CRF is triple that in the general population...
June 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/27927204/different-effect-of-hypercholesterolemia-on-mortality-in-hemodialysis-patients-based-on-coronary-artery-disease-or-myocardial-infarction
#15
Yi-Chun Lin, Yen-Chung Lin, Hsi-Hsien Chen, Tzen-Wen Chen, Chih-Cheng Hsu, Chiung-Chi Peng, Mai-Szu Wu
BACKGROUND: Studies on the association of total cholesterol (TC) levels and mortality in hemodialysis (HD) patients demonstrated conflicting results. The differenct effect of Hypercholesterolemia on HD patients based on the presence of myocardial infarction (MI) or coronary artery disease (CAD) is unknown. METHODS: We analyzed data from the Taiwan Renal Registry Data System (TWRDS) between 2005 and 2012. Patients were divided into MI/CAD or non-MI/CAD group. The primary outcome was three-year mortality...
December 8, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27910804/sudden-cardiac-death-a-nationwide-cohort-study-among-the-young
#16
REVIEW
Bjarke Risgaard
Sudden cardiac death (SCD) is a tragic event affecting millions of individuals worldwide. Although several studies have investigated the epidemiology of SCD, these studies may have been affected by reporting and referral biases, which are reflected in the very different incidence rates and causes of deaths that have previously been reported. Among SCD victims aged < 36 years, inherited cardiac diseases are well known to play an important role. However, the extent to which inherited cardiac diseases also play a role in SCD victims aged < 50 years has not been completely described...
December 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27882006/framingham-risk-score-in-impaired-glucose-tolerant-population-a-sub-analysis-of-diabetes-prevention-and-awareness-program-of-pakistan
#17
Asher Fawwad, Hassan Moin, Iftikhar Ahmed Siddiqui, Muhammad Zafar Iqbal Hydrie, Abdul Basit
OBJECTIVE: To assess the 10-year risk of coronary artery disease (CAD) in subjects with impaired glucose tolerance (IGT) using Framingham risk score. METHODS: Data for this study was collected from Diabetes Prevention and Awareness Program. Primary prevention team visited different primary health care centers, factories, service organizations and offices within Karachi, Pakistan. IGT was diagnosed according to World Health Organization criteria after taking informed consent...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27875636/evaluation-of-coronary-artery-disease-in-potential-liver-transplant-recipients
#18
REVIEW
Brian J Hogan, Enoka Gonsalkorala, Michael A Heneghan
Improvements in the management of patients undergoing liver transplantation (LT) have resulted in a significant increase in survival in recent years. Cardiac disease is now the leading cause of early mortality, and the stress of major surgery, hemodynamic shifts, and the possibilities of hemorrhage or reperfusion syndrome require the recipient to have good baseline cardiac function. The prevalence of coronary artery disease (CAD) is increasing in LT candidates, especially in those with nonalcoholic fatty liver disease...
March 2017: Liver Transplantation
https://www.readbyqxmd.com/read/27815829/genetics-current-and-future-role-in-the-prevention-and-management-of-coronary-artery-disease
#19
REVIEW
Robert Roberts
PURPOSE OF REVIEW: The purpose of this study is to review genetic risk variants for coronary artery disease (CAD) and how they will change the management and prevention of CAD currently and in the future. RECENT FINDINGS: Through the efforts of international consortia, 58 genetic risk variants for CAD of genome-wide significance have been replicated in appropriate independent populations. Only one third of these variants mediate their risk through known conventional risk factors for CAD...
December 2016: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/27798792/bleeding-risk-associated-with-eptifibatide-integrilin-bridging-in-thoracic-surgery-patients
#20
Nathan H Waldron, Torijaun Dallas, Loretta Erhunmwunsee, Tracy Y Wang, Mark F Berry, Ian J Welsby
Antiplatelet use for treatment of coronary artery disease (CAD) is common amongst thoracic surgery patients. Perioperative management of antiplatelet agents requires balancing the opposing risks of myocardial ischemia and excessive bleeding. Perioperative bridging with short-acting intravenous antiplatelet agents has shown promise in preventing myocardial ischemia, but may increase bleeding. We sought to determine whether perioperative bridging with eptifibatide increased bleeding associated with thoracic surgery...
February 2017: Journal of Thrombosis and Thrombolysis
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