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https://www.readbyqxmd.com/read/29776428/evidence-of-the-impact-of-systemic-inflammation-on-neuroinflammation-from-a-non-bacterial-endotoxin-animal-model
#1
Chunxia Huang, Michael Garnet Irwin, Gordon Tin Chun Wong, Raymond Chuen Chung Chang
BACKGROUND: Systemic inflammation induces neuroinflammation and cellular changes such as tau phosphorylation to impair cognitive function, including learning and memory. This study uses a single model, laparotomy without any pathogen, to characterize these changes and their responses to anti-inflammatory treatment in the intermediate term. METHODS: In a two-part experiment, wild-type C57BL/6N mice (male, 3 month old, 25 ± 2 g) were subjected to sevoflurane anesthesia alone or to a laparotomy...
May 17, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29772494/effects-of-ceftriaxone-induced-intestinal-dysbacteriosis-on-regulatory-t-cells-validated-by-anaphylactic-mice
#2
Xia Luo, Zengfeng Pan, Shuang Luo, Qi Liu, Shaowei Huang, Guanghua Yang, Feifei Nong, Yajun Fu, Xiangliang Deng, Lian Zhou
Both probiotics and pathogens in the human gut express pathogen-associated molecular patterns (PAMPs) and die with the release of endotoxin and bacterial DNA, which can stimulate our immune system and cause immune reaction. However, it's interesting and fascinating to address why the normal intestinal flora will not generate immunological rejection like the pathogen does. By investigating the changes in cells and molecules relevant to immune tolerance in mice with ceftriaxone-induced dysbacteriosis, our study discovered that both the Evenness indexes and Shannon Wiener index of intestinal flora showed a decrease in dysbacteriosis mice...
May 14, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29771447/intermedin1-53-protects-cardiac-function-in-rats-with-septic-shock-via-inhibiting-oxidative-stress-and-cardiomyocyte-apoptosis
#3
Y-J Yu, A-H Su, H-B Yang, J-X Chen
OBJECTIVE: To investigate the protective effect of intermedin1-53 (IMD1-53) on cardiac function in rats with septic shock and its underlying mechanism. MATERIALS AND METHODS: Twenty-four male Sprague-Dawley (SD) rats were randomly assigned into three groups, namely the control group (NC group), septic shock group (ET group) and IMD1-53 treatment group (IMD group), with 8 rats in each group. Levels of hemodynamic indicators, blood glucose, lactate acid, CK-MB (creatine kinase-MB) and cTnI (cardiac troponin I) in rats were determined...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29770592/particles-of-vaterite-a-metastable-caco-3-polymorph-exhibit-high-biocompatibility-for-human-osteoblasts-and-endothelial-cells-and-may-serve-as-a-biomaterial-for-rapid-bone-regeneration
#4
Romina Schröder, Laura Besch, Hannah Pohlit, Martin Panthöfer, Wilfried Roth, Holger Frey, Wolfgang Tremel, Ronald E Unger
We have previously described a promising alternative to conventional synthetic bone biomaterials using vaterite, a metastable CaCO3 polymorph, that increases the local Ca2+ concentration in vitro and leads to an over-saturation of phosphate, the primary bone mineral. This stimulates a natural bone-like mineralization in a short period of time. In this study, sterile and endotoxin-free vaterite particles were synthesized in a nearly quantitative yield. The 500-1000 nm vaterite particles did not exhibit any cytotoxic effects as measured by MTT, LDH or crystal violet assays on the human osteoblast cell line (MG-63) exposed to concentrations up to 500 μg/ml vaterite up to 72 hr...
May 16, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29770204/diverse-pro-inflammatory-endotoxin-recognition-systems-of-mammalian-innate-immunity
#5
REVIEW
Jerrold Weiss, Jason Barker
In humans and other mammals, recognition of endotoxins-abundant surface lipopolysaccharides (LPS) of Gram-negative bacteria-provides a potent stimulus for induction of inflammation and mobilization of host defenses. The structurally unique lipid A region of LPS is the principal determinant of this pro-inflammatory activity. This region of LPS is normally buried within the bacterial outer membrane and aggregates of purified LPS, making even more remarkable its picomolar potency and the ability of discrete variations in lipid A structure to markedly alter the pro-inflammatory activity of LPS...
2018: F1000Research
https://www.readbyqxmd.com/read/29768397/lipopolysaccharide-exposure-alleviates-asthma-in-mice-by-regulating-th1-th2-and-treg-th17-balance
#6
Fengxia Ding, Zhou Fu, Bo Liu
BACKGROUND It is generally believed that endotoxin exposure exacerbates risk of developing asthmatic symptoms. However, recent studies have indicated that prior bacterial exposure may prevent future symptoms of asthma. Here, we evaluated the influence of pre-exposure to different concentrations of lipopolysaccharide (LPS) to subsequent ovalbumin (OVA) allergen sensitization and challenge. MATERIAL AND METHODS Four-week-old Balb/c mice were treated intranasally with varying concentrations of LPS (1 ug, 10 ug, and 100 ug) or sterile PBS for 10 days, then 2 weeks later they were exposed to OVA...
May 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29767743/premeal-low-fat-yogurt-consumption-reduces-postprandial-inflammation-and-markers-of-endotoxin-exposure-in-healthy-premenopausal-women-in-a-randomized-controlled-trial
#7
Ruisong Pei, Diana M DiMarco, Kelley K Putt, Derek A Martin, Chureeporn Chitchumroonchokchai, Richard S Bruno, Bradley W Bolling
Background: Metabolic endotoxemia is associated with obesity and contributes to postprandial inflammation. Objective: We aimed to determine if low-fat yogurt consumption prevents postprandial inflammation and dysmetabolism in healthy women by inhibiting biomarkers of metabolic endotoxemia. Methods: Premenopausal women defined as obese and nonobese [body mass index (BMI, in kg/m2) 30-40 and 18.5-27, respectively, n = 120] were randomly assigned to consume 339 g of low-fat yogurt (YN, yogurt nonobese; YO, yogurt obese) or 324 g of soy pudding (CN, control nonobese; CO, control obese) for 9 wk (n = 30/group)...
May 15, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29767701/microbiome-mediated-effects-of-the-mediterranean-diet-on-inflammation
#8
Melisa A Bailey, Hannah D Holscher
The Mediterranean diet pattern is increasingly associated with improved metabolic health. Two mechanisms by which consuming a Mediterranean diet pattern may contribute to improved metabolic health are modulation of the gastrointestinal (GI) microbiota and reduction of metabolic endotoxemia. Metabolic endotoxemia, defined as a 2- to 3-fold increase in circulating levels of bacterial endotoxin, has been proposed as a cause of inflammation during metabolic dysfunction. As the largest source of endotoxins in the human body, the GI microbiota represents a crucial area for research on strategies for reducing endotoxemia...
May 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29765489/gallic-acid-l-leucine-conjugate-protects-mice-against-lps-induced-inflammation-and-sepsis-via-correcting-proinflammatory-lipid-mediator-profiles-and-oxidative-stress
#9
Yuanyuan Cheng, Xuechen Li, Hung-Fat Tse, Jianhui Rong
The pathology of endotoxin LPS-induced sepsis is hallmarked by aberrant production of proinflammatory lipid mediators and nitric oxide (NO). The aim of the present study was to determine whether the new product gallic acid-L-leucine (GAL) conjugate could ameliorate the LPS-induced dysregulation of arachidonic acid metabolism and NO production. We first investigated the effects of GAL conjugate on the expression of proinflammatory enzymes and the production of proinflammatory NO and lipid mediators in mouse macrophage cell line RAW264...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29763693/influence-of-lipopolysaccharide-on-proinflammatory-gene-expression-in-human-corneal-conjunctival-and-meibomian-gland-epithelial-cells
#10
Di Chen, Afsun Sahin, Wendy R Kam, Yang Liu, Raheleh Rahimi Darabad, David A Sullivan
PURPOSE: Lipopolysaccharide (LPS), a bacterial endotoxin, is known to stimulate leuokotriene B4 (LTB4) secretion by human corneal (HCECs), conjunctival (HConjECs) and meibomian gland (HMGECs) epithelial cells. We hypothesize that this LTB4 effect represents an overall induction of proinflammatory gene expression in these cells. Our objective was to test this hypothesis. METHODS: Immortalized HCECs, HConjECs and HMGECs were cultured in the presence or absence of LPS (15 μg/ml) and ligand binding protein (LBP; 150 ng/ml)...
May 12, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29760677/one-week-exposure-to-a-free-choice-high-fat-high-sugar-diet-does-not-interfere-with-the-lipopolysaccharide-induced-acute-phase-response-in-the-hypothalamus-of-male-rats
#11
Evita Belegri, Leslie Eggels, Susanne E la Fleur, Anita Boelen
Obesity has been associated with increased susceptibility to infection in humans and rodents. Obesity is also associated with low-grade hypothalamic inflammation that depends not only on body weight but also on diet. In the present study, we investigated if the bacterial endotoxin [lipopolysaccharide (LPS)]-induced acute phase response is aggravated in rats on a 1-week free-choice high-fat high-sugar (fcHFHS) diet and explained by diet-induced hypothalamic inflammation. Male Wistar rats were on an fcHFHS diet or chow for 1 week and afterwards intraperitoneally injected with LPS or saline...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29759437/cleaning-and-sterilization-of-used-cardiac-implantable-electronic-devices-with-process-validation-the-next-hurdle-in-device-recycling
#12
Thomas C Crawford, Craig Allmendinger, Jay Snell, Kevin Weatherwax, Balasundaram Lavan, Timir S Baman, Pat Sovitch, Daniel Alyesh, Thomas Carrigan, Noah Klugman, Denis Kune, Andrew Hughey, Daniel Lautenbach, Nathan Sovitch, Karman Tandon, George Samson, Charles Newman, Sheldon Davis, Archie Brown, Brad Wasserman, Ed Goldman, Sandra L Arlinghaus, Hakan Oral, Kim A Eagle
OBJECTIVES: This study sought to develop a validated, reproducible sterilization protocol, which could be used in the reprocessing of cardiac implantable electronic devices (CIEDs). BACKGROUND: Access to cardiac CIED therapy in high-income and in low- and middle-income countries varies greatly. CIED reuse may reduce this disparity. METHODS: A cleaning and sterilization protocol was developed that includes washing CIEDs in an enzymatic detergent, screw cap and set screw replacement, brushing, inspection, and sterilization in ethylene oxide...
June 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29758401/factors-determining-the-exposure-of-dairy-farmers-to-thoracic-organic-dust
#13
Hugo Pfister, Laurent Madec, Pierre Le Cann, Nathalie Costet, Martine Chouvet, Stéphane Jouneau, Laurent Vernhet
Bronchial respiratory diseases are more common in dairy farmers than in the general population, perhaps because the repeated inhalation of organic dust contributes to the development of these disorders. However, the factors determining the exposure of farmers to particles that can enter the lower bronchial tract and interact with it, i.e. the thoracic fraction of the inhalable dust, remain to be identified. We therefore measured the exposure of dairy farmers to thoracic organic dust and identified the farm features and tasks that increased exposure...
May 11, 2018: Environmental Research
https://www.readbyqxmd.com/read/29755842/lipopolysaccharide-endotoxemia-induces-amyloid-%C3%AE-and-p-tau-formation-in-the-rat-brain
#14
Li-Ming Wang, Qi Wu, Ryan A Kirk, Kevin P Horn, Ahmed H Ebada Salem, John M Hoffman, Jeffrey T Yap, Joshua A Sonnen, Rheal A Towner, Fernando A Bozza, Rosana S Rodrigues, Kathryn A Morton
Amyloid beta (Aβ) plaques are not specific to Alzheimer's disease and occur with aging and neurodegenerative disorders. Soluble brain Aβ may be neuroprotective and increases in response to neuroinflammation. Sepsis is associated with neurocognitive compromise. The objective was to determine, in a rat endotoxemia model of sepsis, whether neuroinflammation and soluble Aβ production are associated with Aβ plaque and hyperphosphorylated tau deposition in the brain. Male Sprague Dawley rats received a single intraperitoneal injection of 10 mg/kg of lipopolysaccharide endotoxin (LPS)...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29753474/intramammary-25-hydroxyvitamin-d-3-treatment-modulates-innate-immune-responses-to-endotoxin-induced-mastitis
#15
Kathryn E Merriman, Jessi L Powell, Jose E P Santos, Corwin D Nelson
Vitamin D signaling in response to pathogen-associated molecules contributes to activation of innate immune responses of bovine monocytes. We hypothesized that lipopolysaccharide (LPS) of bacteria associated with mastitis in dairy cows activates the vitamin D pathway in innate immune cells of the udder and that increasing availability of 25-hydroxyvitamin D3 [25(OH)D3 ] would augment expression of vitamin D-associated genes. The objective of this experiment was to determine the effects of intramammary LPS and 25(OH)D3 treatments on activation of the vitamin D pathway and innate immune responses of mammary immune cells...
May 9, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29752735/rbpi-21-opebacan-promotes-rapid-trilineage-hematopoietic-recovery-in-a-murine-model-of-high-dose-total-body-irradiation
#16
Kenneth J Janec, Huaiping Yuan, James E Norton, Rowan H Kelner, Christian K Hirt, Rebecca A Betensky, Eva C Guinan
The complexity of providing adequate care after radiation exposure has drawn increasing attention. While most therapeutic development has focused on improving survival at lethal radiation doses, acute hematopoietic syndrome (AHS) occurs at substantially lower exposures. Thus, it is likely that a large proportion of such a radiation-exposed population will manifest AHS of variable degree and that the medical and socioeconomic costs of AHS will accrue. Here, we examined the potential of rBPI21 (opebacan), used without supportive care, to accelerate hematopoietic recovery after radiation where expected survival was substantial (42-75%) at 30 days)...
May 11, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29748216/intrinsic-anti-inflammatory-properties-in-the-serum-of-two-species-of-deep-diving-seal
#17
Aranya Bagchi, Annabelle J Batten, Milton Levin, Kaitlin N Allen, Michael L Fitzgerald, Luis A Hückstädt, Daniel P Costa, Emmanuel S Buys, Allyson G Hindle
Weddell and elephant seals are deep diving mammals, which rely on lung collapse to limit nitrogen absorption and prevent decompression injury. Repeated collapse and re-expansion exposes the lungs to multiple stressors, including ischemia/reperfusion, alveolar shear stress, and inflammation. There is no evidence, however, that diving damages pulmonary function in these species. To investigate potential protective strategies in deep-diving seals, we examined the inflammatory response of seal whole blood exposed to lipopolysaccharide (LPS), a potent endotoxin...
May 10, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29746405/long-term-physical-stability-sterility-and-anti-vegf-bioactivity-of-repackaged-bevacizumab-in-2-ml-glass-vials
#18
Jan S Peterson, Kenneth Rockwell, Ingrid U Scott, Michael S Ip, Paul C VanVeldhuisen, Barbara A Blodi
PURPOSE: Repackaged bevacizumab in single-dose, prefilled syringes for intravitreal injection is available, but with shelf life limited from 60 days to 90 days. For the Study of COmparative Treatments for REtinal Vein Occlusion 2 (SCORE2), 2-mL sterile glass vials were used rather than prefilled syringes to provide a longer shelf life for study supplies. METHODS: Repackaged bevacizumab in glass vials was tested at release and, for 1 lot, after 1, 3, 6, and 12 months for physical stability, including concentration, purity and appearance, and for sterility and endotoxins...
May 9, 2018: Retina
https://www.readbyqxmd.com/read/29743185/lung-cancer-mortality-and-exposure-to-synthetic-metalworking-fluid-and-biocides-controlling-for-the-healthy-worker-survivor-effect
#19
Erika Garcia, Sally Picciotto, Andreas M Neophytou, Patrick T Bradshaw, John R Balmes, Ellen A Eisen
OBJECTIVES: Synthetic metalworking fluids (MWFs), widely used to cool and lubricate industrial machining and grinding operations, have been linked with increased risk of several cancers. Estimates of their relation with lung cancer, however, are inconsistent. Controlling for the healthy worker survivor effect, we examined the relations between lung cancer mortality and exposure to synthetic MWF, as well as to biocides added to water-based fluids to control microbial growth, in a cohort of autoworkers...
May 9, 2018: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29737632/mesenchymal-stem-cell-microvesicles-restore-protein-permeability-across-primary-cultures-of-injured-human-lung-microvascular-endothelial-cells
#20
Shuling Hu, Jeonghyun Park, Airan Liu, JaeHoon Lee, Xiwen Zhang, Qi Hao, Jae-Woo Lee
Our previous study demonstrated that mesenchymal stem cell (MSC) microvesicles (MV) reduced lung inflammation, protein permeability, and pulmonary edema in endotoxin-induced acute lung injury in mice. However, the underlying mechanisms for restoring lung protein permeability were not fully understood. In this current study, we hypothesized that MSC MV would restore protein permeability across injured human lung microvascular endothelial cells (HLMVEC) in part through the transfer of angiopoietin-1 (Ang1) mRNA to the injured endothelium...
May 8, 2018: Stem Cells Translational Medicine
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