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Atenolol

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https://www.readbyqxmd.com/read/28431453/carboxymethyl-%C3%AE-cyclodextrin-as-chiral-selector-in-capillary-electrophoresis-enantioseparation-of-16-basic-chiral-drugs-and-its-chiral-recognition-mechanism-associated-with-drugs-structural-features
#1
Linlin Fang, Yueying Du, Xiaoyu Hu, Linda Luo, Xin Guo, Xingjie Guo, Jia Yu
Herein we present the enantioseparation of 10 cardiovascular agents and 6 bronchiectasis drugs including propranolol, carteolol, metoprolol, atenolol, pindolol, esmolol, bisoprolol, bevantolol, arotinolol, sotalol, clenbuterol, procaterol, bambuterol, tranterol, salbutamol and terbutaline sulfate using carboxymethyl-β-cyclodextrin (CM-β-CD) as chiral selector. To our knowledge, there is no literature about using CM-β-CD for separating carteolol, esmolol, bisoprolol, bevantolol, arotinolol, procaterol, bambuterol and tranterol...
April 21, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28424658/%C3%AE-and-%C3%AE-2-adrenoceptor-control-of-vascular-tension-and-catecholamine-release-in-female-normotensive-and-spontaneously-hypertensive-rats
#2
Torill Berg
As in humans, young, female, spontaneously hypertensive rats (SHR) have a lower blood pressure than male SHR. In male, normotensive rats (WKY), α2- and β1+2-adrenoceptors (AR) reciprocally controlled catecholamine release and vascular smooth muscle tension. This interaction was malfunctioning in male SHR. The present study analyzed if a favorable shift in the α2/β1+2AR interaction may represent an antihypertensive protection in females. Female SHR (early hypertension, 12-14 weeks) and age-matched WKY were infused with tyramine (15 min) to stimulate norepinephrine (NE) release through the reuptake transporter, consequently preventing reuptake...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28414144/intestinal-drug-interactions-mediated-by-oatps-a-systematic-review-of-pre-clinical-and-clinical-findings
#3
REVIEW
Jingjing Yu, Zhu Zhou, Jessica Tay-Sontheimer, René H Levy, Isabelle Ragueneau-Majlessi
In recent years, an increasing number of clinical drug-drug interactions (DDIs) have been attributed to inhibition of intestinal organic anion transporting polypeptides (OATPs); however, only a few of these DDI results were reflected in drug labels. This review aims to provide a thorough analysis of intestinal OATP-mediated pharmacokinetic-based DDIs, using both in vitro and clinical investigations, highlighting the main mechanistic findings and discussing their clinical relevance. On the basis of pharmacogenetic and clinical DDI results, a total of 12 drugs were identified as possible clinical substrates of OATP2B1 and/or OATP1A2...
April 13, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28410967/involvement-of-alpha-and-beta-adrenoceptors-in-the-automaticity-of-the-isolated-guinea-pig-pulmonary-vein-myocardium
#4
Masahiko Irie, Yayoi Tsuneoka, Mariko Shimobayashi, Nao Hasegawa, Yusuke Tanaka, Soh Mochizuki, Sho Ichige, Shogo Hamaguchi, Iyuki Namekata, Hikaru Tanaka
We examined the involvement of adrenoceptors in the automaticity of the pulmonary vein myocardium, which probably plays a crucial role in the generation of atrial fibrillation. The automatic activity of the myocardium in guinea pig pulmonary vein tissue preparations were monitored by contractile force or membrane potential measurement. In quiescent preparations, application of noradrenaline induced an automatic activity. The firing frequency was reduced by prazosin or atenolol. Methoxamine induced an automatic activity of low frequency, which was accelerated by further application of isoproterenol...
March 29, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28405886/pharmacokinetic-variability-of-drugs-used-for-prophylactic-treatment-of-migraine
#5
REVIEW
Peer Tfelt-Hansen, Frederik Nybye Ågesen, Agniezka Pavbro, Jacob Tfelt-Hansen
In this review, we evaluate the variability in the pharmacokinetics of 11 drugs with established prophylactic effects in migraine to facilitate 'personalized medicine' with these drugs. PubMed was searched for 'single-dose' and 'steady-state' pharmacokinetic studies of these 11 drugs. The maximum plasma concentration was reported in 248 single-dose and 115 steady-state pharmacokinetic studies, and the area under the plasma concentration-time curve was reported in 299 single-dose studies and 112 steady-state pharmacokinetic studies...
April 12, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28402006/virus-myocarditis-in-a-1-month-old-boy-presenting-as-two-types-of-paroxysmal-supraventricular-tachycardia
#6
Shuhei Fujita, Takeshi Futatani, Tatsuya Kubo, Masae Itamochi, Yusuke Yachi, Hidenori Iwasaki, Ayako Shimao, Shihomi Ina, Hiroyuki Higashiyama, Noboru Igarashi, Kiyoshi Hatasaki
Herein we describe the case of a 1-month-old boy with acute viral myocarditis, who presented with two kinds of paroxysmal supraventricular tachycardia, and who was cured after medical treatment. He was brought to the emergency room with poor feeding due to fever. On the third day of hospitalization, a narrow QRS tachycardia (180-200 beats/min) was detected. Echocardiography showed a high echoic area at the atrial septum around the atrioventricular node. The patient was clinically diagnosed with acute myocarditis...
April 12, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28397088/combination-of-anti-hypertensive-drugs-a-molecular-dynamics-simulation-study
#7
Abbas Yousefpour, Hamid Modarress, Fatemeh Goharpey, Sepideh Amjad-Iranagh
The anti-hypertensive drugs amlodipine, atenolol and lisinopril, in ordinary and PEGylated forms, with different combined-ratios, were studied by molecular dynamics simulations using GROMACS software. Twenty simulation systems were designed to evaluate the interactions of drug mixtures with a dimyristoylphosphatidylcholine (DMPC) lipid bilayer membrane, in the presence of water molecules. In the course of simulations, various properties of the systems were investigated, including drug location, diffusion and mass distribution in the membrane; drug orientation; the lipid chain disorder as a result of drug penetration into the DMPC membrane; the number of hydrogen bonds; and drug surface area...
May 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28390280/removal-of-pharmaceuticals-in-conventionally-treated-wastewater-by-a-polishing-moving-bed-biofilm-reactor-mbbr-with-intermittent-feeding
#8
Kai Tang, Gordon T H Ooi, Klaus Litty, Kim Sundmark, Kamilla M S Kaarsholm, Christina Sund, Caroline Kragelund, Magnus Christensson, Kai Bester, Henrik R Andersen
Previous studies have demonstrated that aerobic moving bed biofilm reactors (MBBRs) remove pharmaceuticals better than activated sludge. Thus we used a MBBR system to polish the effluent of an activated sludge wastewater treatment plant. To overcome that effluent contains insufficient organic matter to sustain enough biomass, the biofilm was intermittently fed with raw wastewater. The capacity of pharmaceutical degradation was investigated by spiking pharmaceuticals. Actual removal during treatment was assessed by sampling the inlets and outlets of reactors...
March 30, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28389095/chemometric-evaluation-of-the-combined-effect-of-temperature-pressure-and-co-solvent-fractions-on-the-chiral-separation-of-basic-pharmaceuticals-using-actual-vs-set-operational-conditions
#9
Erik Forss, Dan Haupt, Olle Stålberg, Martin Enmark, Jörgen Samuelsson, Torgny Fornstedt
The need to determine the actual operational conditions, instead of merely using the set operational conditions, was investigated for in packed supercritical fluid chromatography (SFC) by design of experiments (DoE) using a most important type of compounds, pharmaceutical basics, as models. The actual values of temperature, pressure, and methanol levels were recorded and calculated from external sensors, while the responses in the DoE were the retention factors and selectivity. A Kromasil CelluCoat column was used as the stationary phase, carbon dioxide containing varying methanol contents as the mobile phase, and the six racemates of alprenolol, atenolol, metoprolol, propranolol, clenbuterol, and mianserin were selected as model solutes...
March 28, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28384602/removal-characteristics-of-pharmaceuticals-and-personal-care-products-comparison-between-membrane-bioreactor-and-various-biological-treatment-processes
#10
Junwon Park, Naoyuki Yamashita, Chulhwi Park, Tatsumi Shimono, Daniel M Takeuchi, Hiroaki Tanaka
We investigated the concentrations of 57 target compounds in the different treatment units of various biological treatment processes in South Korea, including modified biological nutrient removal (BNR), anaerobic-anoxic-aerobic (A2O), and membrane bioreactor (MBR) systems, to elucidate the occurrence and removal fates of PPCPs in WWTPs. Biological treatment processes appeared to be most effective in eliminating most PPCPs, whereas some PPCPs were additionally removed by post-treatment. With the exception of the MBR process, the A2O system was effective for PPCPs removal...
April 2, 2017: Chemosphere
https://www.readbyqxmd.com/read/28369986/preconcentration-of-%C3%AE-blockers-using-functionalized-ordered-mesoporous-silica-as-sorbent-for-solid-phase-extraction-and-their-determination-in-waters-by-chiral-capillary-electrophoresis
#11
Mariana Silva, Sonia Morante-Zarcero, Damián Pérez-Quintanilla, María Luisa Marina, Isabel Sierra
A method for simultaneous separation and determination of four enantiomeric pairs of β-blockers in waters by chiral capillary electrophoresis (CE) has been developed. Off-line solid phase extraction (SPE) was employed using functionalized ordered mesoporous silica as sorbent. Separation by CE was achieved using a background electrolyte composed by methylated-β-CD (1.25% w/v) dissolved in a 50 mM phosphate buffer (pH 2.5) and 30 °C, with good chiral resolution for all enantiomers. Mesoporous silica functionalized with octadecyl groups (denoted SBA15-C18) was prepared by a post-synthesis method and applied for the preconcentration of atenolol, propranolol, metoprolol and pindolol enantiomers in waters by off-line SPE...
March 30, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28353407/replicated-evidence-for-aminoacylase-3-and-nephrin-gene-variations-to-predict-antihypertensive-drug-responses
#12
Jenni M Rimpelä, Kimmo K Kontula, Frej Fyhrquist, Kati M Donner, Annukka M Tuiskula, Antti-Pekka Sarin, Robert P Mohney, Steven M Stirdivant, Timo P Hiltunen
AIM: To replicate the genome-wide associations of the antihypertensive effects of bisoprolol and losartan in GENRES, using the Finnish patients of LIFE study. PATIENTS & METHODS: We analyzed association of four SNPs with atenolol and three SNPs with losartan response in 927 Finnish LIFE patients (467 for atenolol and 460 for losartan). RESULTS: rs2514036, a variation at a transcription start site of ACY3, was associated with blood pressure response to atenolol in men in LIFE...
March 29, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28353311/blockade-of-beta2-adrenoceptor-rather-than-beta1-adrenoceptor-deteriorates-cardiac-anaphylaxis-in-isolated-blood-perfused-rat-hearts
#13
Yuhichi Kuda, Toshishige Shibamoto, Wei Yang, Tao Zhang, Mamoru Tanida, Yasutaka Kurata
BACKGROUND: Cardiac anaphylaxis is one of the features of anaphylactic hypotension. Patients treated with propranolol, a nonselective b-adrenoceptor (AR) antagonist, develop severe anaphylaxis, but the mechanism remains unknown. Under examination were the effects of b₁- and b₂-AR antagonist on anaphylaxis-induced coronary vasoconstriction and cardiac dysfunction in isolated blood-perfused rat hearts. METHODS: Isolated hearts from ovalbumin-sensitized Wistar rats were subjected to coronary perfusion with blood at a constant pressure and measurements were made of coronary blood flow and left ventricular (LV) pressure...
March 29, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28351746/competition-and-enhancement-effect-in-coremoval-of-atenolol-and-copper-by-an-easily-regenerative-magnetic-cation-exchange-resin
#14
Qimeng Li, Zheng Wang, Qiang Li, Chendong Shuang, Qing Zhou, Aimin Li, Canzhu Gao
This paper aimed to investigate the removal of combined Cu(2+) and atenolol (ATL) in aqueous solution by using a newly synthesized magnetic cation exchange resin (MCER) as the adsorbent. The MCER exhibited efficient removal performance in sole, binary, pre-loading and saline systems. The adsorption kinetics of Cu(2+) and ATL fitted both pseudo-first-order and pseudo-second order model, while better described by pseudo-second order model in binary system. In mixed Cu(2+) and ATL solution, the adsorption of ATL was suppressed due to direct competition of carboxylic groups, while Cu(2+) adsorption was enhanced because of the formation of surface complexes...
March 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28345378/probing-the-behavior-of-bovine-serum-albumin-upon-binding-to-atenolol-insights-from-spectroscopic-and-molecular-docking-approaches
#15
Tuo-Ying Jiang, Kai-Li Zhou, Yan-Yue Lou, Dong-Qi Pan, Jie-Hua Shi
Molecular interaction of atenolol, a selective β1 receptor antagonist with the major carrier protein, bovine serum albumin (BSA), was investigated under imitated physiological conditions (pH 7.4) by means of fluorescence spectroscopy, UV absorption spectroscopy, Fourier transform infrared spectroscopy (FT-IR), and molecular modeling studies. The steady-state fluorescence spectra manifested that static type, due to formation of the atenolol-BSA complex, was the dominant mechanism for fluorescence quenching...
March 27, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28344390/algal-cultivation-in-urban-wastewater-an-efficient-way-to-reduce-pharmaceutical-pollutants
#16
Francesco G Gentili, Jerker Fick
The purpose of this study was to investigate whether pharmaceutical pollutants in urban wastewater can be reduced during algal cultivation. A mixed population of wild freshwater green algal species was grown on urban wastewater influent in a 650 L photobioreactor under natural light and with the addition of flue gases. Removal efficiencies were very high (>90 %), moderate (50-90 %), low (10-50 %), and very low or non-quantifiable (<10 %) for 9, 14, 11, and 18 pharmaceuticals, respectively, over a 7-day period...
2017: Journal of Applied Phycology
https://www.readbyqxmd.com/read/28342346/can-wastewater-based-epidemiology-be-used-to-evaluate-the-health-impact-of-temperature-an-exploratory-study-in-an-australian-population
#17
Dung Phung, Jochen Mueller, Foon Yin Lai, Jake O'Brien, Nhung Dang, Lidia Morawska, Phong K Thai
Ambient temperature is known to have impact on population health but assessing its impact by the traditional cohort approach is resource intensive. Wastewater-based epidemiology (WBE) could be an alternative for the traditional approach. This study was to provide the first evaluation to see if WBE can be used to assess the impact of temperature exposure to a population in South East Queensland, Australia using selected pharmaceuticals and personal care products (PPCPs) as biomarkers. Daily loads of eight PPCPs in wastewater collected from a wastewater treatment plant were measured from February 2011 to June 2012...
March 22, 2017: Environmental Research
https://www.readbyqxmd.com/read/28332406/continuous-glucose-monitor-interference-with-commonly-prescribed-medications
#18
Ananda Basu, Michael Q Slama, Wayne T Nicholson, Loralie Langman, Thomas Peyser, Rickey Carter, Rita Basu
BACKGROUND: Reliability of continuous glucose monitors (CGM) is a prerequisite for therapeutic dosing of insulin without the need for confirmatory blood glucose meter measurements. Interference of CGMs with commonly prescribed substances has not been extensively evaluated. METHODS: We sought to undertake a novel pilot study to determine the susceptibility of FDA-approved CGM systems (Medtronic Guardian Sof-Sensor, Dexcom G4 Platinum) to erroneous readings in the presence of common medications...
March 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28320606/autoantibodies-with-beta-adrenergic-activity-from-chronic-chagasic-patients-induce-cardiac-arrhythmias-and-early-afterdepolarization-in-a-drug-induced-lqt2-rabbit-hearts
#19
Marco Antonio Vidal Jiménez, José H M Nascimento, Gustavo Monnerat, Leonardo Maciel, Claudia N Paiva, Roberto Coury Pedrosa, Antonio C Campos de Carvalho, Emiliano Medei
BACKGROUND: Cardiac arrhythmias are one of the main causes of death in ChCP and other dilated cardiomyopathies. Previous studies demonstrated that ventricular arrhythmias are associated with the presence of autoantibodies with beta-adrenergic activity, Ab-β. OBJECTIVES: The aim of this study was to investigate whether Ab-β, present in chronic chagasic patients (ChCP), induce cardiac arrhythmias in the pharmacological type-2 long QT syndrome model (LQTS-2). METHODS/RESULTS: The LQTS2 was established by perfusion of Tyrode saline solution with a potassium channel blocker E-4031 (5μM) in isolated rabbit hearts or in rabbit cardiac strips, in order to record ECG or action potential, respectively...
March 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28300420/a-new-lc-ms-ms-bioanalytical-method-for-atenolol-in-human-plasma-and-milk
#20
Ei Mon Phyo Lwin, Cobus Gerber, Yunmei Song, Catherine Leggett, Usha Ritchie, Sean Turner, Sanjay Garg
AIM: A new sensitive LC-MS/MS method for the quantification of atenolol in human plasma and milk has been developed for clinical lactation studies. METHODS & RESULTS: Atenolol and the internal standard, phenazone, were extracted from biological matrices by protein precipitation. A Phenomenex(®) C-18 column and gradient chromatographic conditions were used for separation of the analyte, followed by detection with MS. Stability of samples was confirmed for atenolol in human plasma and milk for up to 3 months...
March 16, 2017: Bioanalysis
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