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https://www.readbyqxmd.com/read/29783197/quantification-of-21-antihypertensive-drugs-in-serum-using-uhplc-ms-ms
#1
Per Ole M Gundersen, Arne Helland, Olav Spigset, Solfrid Hegstad
BACKGROUND: Poor drug adherence in hypertensive patients can lead to treatment failure and increased cardiovascular morbidity, as well as increased costs to society. An analytical method based on ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MSMS) was developed and validated for use in routine therapeutic drug monitoring (TDM). The method includes 21 antihypertensive drugs or active metabolites from the groups beta blockers (n=5), calcium antagonists (n=5), angiotensin II receptor antagonists (n=4), angiotensin converting enzyme (ACE) inhibitors (n=3) and diuretics (n = 3), in addition to one α1-selective alpha blocker...
April 28, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29779481/absorptive-and-secretory-transport-of-selected-artemisinin-derivatives-across-caco-2-cell-monolayers
#2
Jaco Heyns, Clarissa Willers, Richard K Haynes, Ho N Wong, Josias H Hamman, Chrisna Gouws
Malaria continues to be a major health concern and affects more than 200 million people a year. Drugs currently used for treatment of malaria are increasingly rendered ineffectual by the ongoing emergence of parasite resistance. For any new drugs, however, knowledge of their membrane permeability is an essential pre-requisite for eventual use. Treatment failure and emergence of resistance can occur as a result of reduced availability of the drug at the desired site of action. Cell-based permeability assays such as Caco-2 cell monolayers serve as a model for predicting drug absorption and efflux, and provide an estimate of drug bioavailability...
May 18, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29752864/%C3%AE-blockers-interfere-with-cell-homing-receptors-and-regulatory-proteins-in-a-model-of-spontaneously-hypertensive-rats
#3
Bruna Eibel, Melissa Kristochek, Thiago R Peres, Lucinara D Dias, Daniela R Dartora, Karina R Casali, Renato A K Kalil, Alexandre M Lehnen, Maria Claudia Irigoyen, Melissa M Markoski
AIM: To examine the interference of β-blockers with the chemokine stromal cell-derived factor-1 (SDF-1) found in cell homing receptors, C-X-C chemokine receptor type 4 (CXCR-4) and CXCR-7 and regulatory proteins of homing pathways, we administered atenolol, carvedilol, metoprolol and propranolol for 30 days using an orogastric tube to hypertensive rats. METHOD: We collected blood samples before and after treatment and quantified the levels of SDF-1 with enzyme linked immunosorbent assay (ELISA)...
May 12, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29748091/development-and-validation-of-a-hydrophilic-interaction-liquid-chromatography-tandem-mass-spectrometry-method-for-the-quantification-of-the-antidiabetic-drug-metformin-and-six-others-pharmaceuticals-in-wastewater
#4
Reinhard Oertel, Julien Baldauf, Julia Rossmann
A rapid and sensitive hydrophilic interaction liquid chromatography (HILIC)-tandem mass spectrometry method was developed and fully validated for the simultaneous determination of the antidiabetic drug metformin and six further pharmaceuticals (atenolol, gabapentin, levofloxacin, ciprofloxacin, propranolol and trimethoprim) in influent and effluent wastewater. Five deuterated related compounds were used as internal standards in order to control the extraction, injection and ionization variability. Two solid phase extraction methods and Oasis HLB 1cc cartridge, using only 1 mL sample with acid or basic pH-value were optimized and compared in order to match the specificity of both influent and effluent wastewater matrixes...
May 4, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29744815/correction-to-first-development-optimization-and-stability-control-of-a-pediatric-oral-atenolol-formulation
#5
Mauro Morri, Patricia Castellano, Darío Leonardi, Silvana Vignaduzzo
In the INTRODUCTION section, Atenolol is defined in parenthesis as (ATN, Fig. 1.) The correct definition is (ATN). Fig 1 corresponds to the RESULTS section.
April 16, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29728280/intensification-of-uv-c-tertiary-treatment-disinfection-and-removal-of-micropollutants-by-sulfate-radical-based-advanced-oxidation-processes
#6
J Rodríguez-Chueca, C García-Cañibano, R-J Lepistö, Á Encinas, J Pellinen, J Marugán
This study explores the enhancement of UV-C tertiary treatment by sulfate radical based Advanced Oxidation Processes (SR-AOPs), including photolytic activation of peroxymonosulfate (PMS) and persulfate (PS) and their photocatalytic activation using Fe(II). Their efficiency was assessed both for the inactivation of microorganisms and the removal or micropollutants (MPs) in real wastewater treatment plant effluents. Under the studied experimental range (UV-C dose 5.7-57 J/L; UV-C contact time 3 to 28 s), the photolysis of PMS and PS (0...
April 21, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29728279/occurrence-control-and-fate-of-contaminants-of-emerging-concern-in-environmental-compartments-in-brazil
#7
Maria Clara V M Starling, Camila C Amorim, Mônica Maria D Leão
This is the first review to present data obtained in Brazil over the years regarding contaminants of emerging concern (CEC) and to contrast it with contamination in other countries. Data gathered indicated that caffeine, paracetamol, atenolol, ibuprofen, cephalexin and bisphenol A occur in the μg L-1 range in streams near urban areas. While endocrine disruptors are frequently detected in surface waters, highest concentrations account for 17α-ethynylestradiol and 17β-estradiol. Organochlorine pesticides are the most frequently found and persistent in sediments in agricultural regions...
April 22, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29724583/evaluation-of-tricuspid-annular-plane-systolic-excursion-measured-by-two-dimensional-echocardiography-in-healthy-dogs-repeatability-reference-intervals-and-comparison-with-m-mode-assessment
#8
L C Visser, D J Sintov, M S Oldach
INTRODUCTION: We sought to determine the feasibility, measurement variability, and within-day repeatability of tricuspid annular plane systolic excursion (TAPSE) measured by two-dimensional echocardiography (2D TAPSE), generate reference intervals for 2D TAPSE, assess agreement and correlation between 2D TAPSE and the conventional TAPSE measured by M-mode echocardiography (MM TAPSE), and to assess the ability of 2D TAPSE to track a drug-induced decrease in right ventricular (RV) function compared with MM TAPSE...
April 30, 2018: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/29715759/cardioprotective-effect-of-amaranthus-tricolor-extract-in-isoprenaline-induced-myocardial-damage-in-ovariectomized-rats
#9
Kamrun Nahar, Fariha Kabir, Priota Islam, Md Mizanur Rahman, Md Abdullah Al Mamun, Md Faruk, Nusrat Subhan, G M Sayedur Rahman, Hasan Mahmud Reza, Md Ashraful Alam
Red spinach (Amaranthus tricolor) has been reported to possess many benefits and medicinal properties and used as a part of traditional medicine in Ayurveda and Siddha. The aim of the study was to investigate the effects of Amaranthus tricolor on isoproterenol-induced oxidative stress, fibrosis, and myocardial damage in ovariectomized rats. Ovariectomy surgery was conducted to remove both ovaries from the rats. After recovery, rats were administered with ISO subcutaneously (50 mg/kg) twice a week and were treated with ethanolic extracts of A...
April 27, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29710617/illicit-drugs-and-pharmaceuticals-in-swimming-pool-waters
#10
G Fantuzzi, G Aggazzotti, E Righi, G Predieri, S Castiglioni, F Riva, E Zuccato
The occurrence of illicit drugs (cocaine, opioids, amphetamines and cannabis derivatives), some of their metabolites and 48 pharmaceuticals, was investigated in pool and source waters in ten Italian indoor swimming pools. The samples were analyzed by highperformance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), after solid phase extraction (SPE). Cocaine and its metabolites were found in nine swimming pools, at concentrations from 0.3 to 4.2 ng/L for cocaine, 1.1 to 48.7 ng/L for norcocaine, 0...
April 20, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29710587/sorption-of-pharmaceuticals-to-soil-organic-matter-in-a-constructed-wetland-by-electrostatic-interaction
#11
Jongkwan Park, Kyung Hwa Cho, Eunkyung Lee, Sungyun Lee, Jaeweon Cho
There is a growing interest in the removal of pharmaceuticals from wastewater because pharmaceuticals have potential ecotoxicological effects. Among several removal mechanisms, the sorption of pharmaceuticals to sediment organic matter is an important mechanism related to the mobility of pharmaceuticals. This study investigated the sorption of pharmaceuticals to soil organic matter (SOM) by electrostatic interactions. SOM located on the surface of soil/sediment generally has a negative charge because of the functional groups present (i...
April 23, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29705646/sol-gel-based-biogenic-silica-composite-as-green-nanosorbent-for-chemometric-optimization-of-micro-solid-phase-extraction-of-beta-blockers
#12
Hakimu Nsubuga, Chanbasha Basheer, Muhammad Baseer Haider, Rasheed Bakdash
An environmentally friendly micro-solid phase extraction (μ-SPE) method utilizing a plant based nanocomposite as a sorbent for determination of trace level beta blockers (ß-blockers) in hospital wastewater prior to Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. μ-SPE extraction conditions were evaluated using a multivariate chemometric approach. Rice husk silica-carbon nanocomposite (5-20 Wt.% Fe) in glycerol were synthesized via hydrolytic sol-gel method. The nanosorbent were fully characterized and then evaluated for μ-SPE of trace level ß-blockers in hospital wastewater...
April 21, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29703387/food-drug-interactions-precipitated-by-fruit-juices-other-than-grapefruit-juice-an-update-review
#13
REVIEW
Meng Chen, Shu-Yi Zhou, Erlinda Fabriaga, Pian-Hong Zhang, Quan Zhou
This review addressed drug interactions precipitated by fruit juices other than grapefruit juice based on randomized controlled trials (RCTs). Literature was identified by searching PubMed, Cochrane Library, Scopus and Web of Science till December 30 2017. Among 46 finally included RCTs, six RCTs simply addressed pharmacodynamic interactions and 33 RCTs studied pharmacokinetic interactions, whereas seven RCTs investigated both pharmacokinetic and pharmacodynamic interactions. Twenty-two juice-drug combinations showed potential clinical relevance...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29702480/spectrofluorimetric-method-for-atenolol-determination-based-on-gold-nanoparticles
#14
Esam Bakir, Mohamed Gouda, Ahmed Alnajjar, Waleed E Boraie
A simple and sensitive spectrofluorimetric method for determination of atenolol (ATE) using gold nanoparticles (AuNPs) was developed. The method is based on the quenching effect of atenolol on photoluminescence of AuNPs at λem = 705 nm. Variables affecting luminescence of gold nanoparticles such as the solvent, pH value and surfactant were studied and optimized. The method was preliminarily validated according to ICH guidelines. A linear correlation was recorded within the range of 1.0-10 mg mL-1 ATE with the coefficient of determination R2 of 0...
June 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29702422/assessing-the-removal-of-organic-micropollutants-by-a-novel-baffled-osmotic-membrane-bioreactor-microfiltration-hybrid-system
#15
Nirenkumar Pathak, Sheng Li, Youngjin Kim, Laura Chekli, Sherub Phuntsho, Am Jang, Noreddine Ghaffour, TorOve Leiknes, Ho Kyong Shon
A novel approach was employed to study removal of organic micropollutants (OMPs) in a baffled osmotic membrane bioreactor-microfiltration (OMBR-MF) hybrid system under oxicanoxic conditions. The performance of OMBR-MF system was examined employing three different draw solutes (DS), and three model OMPs. The highest forward osmosis (FO) membrane rejection was attained with atenolol (100%) due to its higher molar mass and positive charge. With inorganic DS caffeine (94-100%) revealed highest removal followed by atenolol (89-96%) and atrazine (16-40%) respectively...
April 14, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29679752/thermodynamic-compatibility-between-cyclodextrin-supramolecular-complexes-and-surfactant
#16
Larissa H R Meira, Guilherme A B Soares, Homero I M Bonomini, Juliana Fedoce Lopes, Frederico B De Sousa
Supramolecular structures based on cyclodextrins have been extensively used for drug delivery systems over decades. However, combining host and guest molecules in a pharmaceutical formulation is not a trivial process, being one of the majors concern the inclusion complex compatibility with other excipients presented in the final formulation. Herein, experimental and theoretical calculations were used to investigate the competition of sodium dodecyl sulfate (SDS) with atenolol (ATE) or losartan (LOS), antihypertensive drugs widely used in the treatment of hypertension...
April 18, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29674046/development-of-a-chromatographic-method-with-multi-criteria-decision-making-design-for-simultaneous-determination-of-nifedipine-and-atenolol-in-content-uniformity-testing
#17
Sameh Ahmed, Abdulmalik Alqurshi, Abdel-Maaboud Ismail Mohamed
A new robust and reliable high-performance liquid chromatography (HPLC) method with multi-criteria decision making (MCDM) approach was developed to allow simultaneous quantification of atenolol (ATN) and nifedipine (NFD) in content uniformity testing. Felodipine (FLD) was used as an internal standard (I.S.) in this study. A novel marriage between a new interactive response optimizer and a HPLC method was suggested for multiple response optimizations of target responses. An interactive response optimizer was used as a decision and prediction tool for the optimal settings of target responses, according to specified criteria, based on Derringer's desirability...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29670504/clozapine-induced-cardiovascular-side-effects-and-autonomic-dysfunction-a-systematic-review
#18
Jessica W Y Yuen, David D Kim, Ric M Procyshyn, Randall F White, William G Honer, Alasdair M Barr
Background: Clozapine is the antipsychotic of choice for treatment-resistant schizophrenia and has minimal risk for extrapyramidal symptoms. Therapeutic benefits, however, are accompanied by a myriad of cardiometabolic side-effects. The specific reasons for clozapine's high propensity to cause adverse cardiometabolic events remain unknown, but it is believed that autonomic dysfunction may play a role in many of these. Objective: This systematic review summarizes the literature on autonomic dysfunction and related cardiovascular side effects associated with clozapine treatment...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29650764/genetic-variants-influencing-plasma-renin-activity-in-hypertensive-patients-from-the-pear-study-pharmacogenomic-evaluation-of-antihypertensive-responses
#19
Caitrin W McDonough, Oyunbileg Magvanjav, Ana C C Sá, Nihal M El Rouby, Chintan Dave, Amelia N Deitchman, Marina Kawaguchi-Suzuki, Wenbin Mei, Yong Shen, Ravi Shankar Prasad Singh, Mohamed Solayman, Kent R Bailey, Eric Boerwinkle, Arlene B Chapman, John G Gums, Amy Webb, Steven E Scherer, Wolfgang Sadee, Stephen T Turner, Rhonda M Cooper-DeHoff, Yan Gong, Julie A Johnson
BACKGROUND: Plasma renin is an important regulator of blood pressure (BP). Plasma renin activity (PRA) has been shown to correlate with variability in BP response to antihypertensive agents. We conducted a genome-wide association study to identify single-nucleotide polymorphisms (SNPs) associated with baseline PRA using data from the PEAR study (Pharmacogenomic Evaluation of Antihypertensive Responses). METHODS: Multiple linear regression analysis was performed in 461 whites and 297 blacks using an additive model, adjusting for age, sex, and ancestry-specific principal components...
April 2018: Circulation. Genomic and precision medicine
https://www.readbyqxmd.com/read/29627347/trpa1-mediates-the-cardiac-effects-of-acrolein-through-parasympathetic-dominance-but-also-sympathetic-modulation-in-mice
#20
Nicole Kurhanewicz, Allen Ledbetter, Aimen Farraj, Mehdi Hazari
Numerous studies have demonstrated that short-term air pollution exposure causes cardiac autonomic imbalance as measured by heart rate variability (HRV). We previously showed that a single exposure to acrolein, a ubiquitous gaseous component of air pollution, not only causes autonomic imbalance, but also increases arrhythmia through transient receptor potential A1 (TRPA1) cation channels. Thus, the goal of this study was to characterize acrolein-induced autonomic changes in both normal and TRPA1-knockout mice (KO)...
April 5, 2018: Toxicology and Applied Pharmacology
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