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https://www.readbyqxmd.com/read/29350751/review-of-the-comparative-susceptibility-of-microbial-species-to-photoinactivation-using-380-480%C3%A2-nm-violet-blue-light
#1
Rachael M Tomb, Tracy A White, John E Coia, John G Anderson, Scott J MacGregor, Michelle Maclean
Antimicrobial violet-blue light is an emerging technology designed for enhanced clinical decontamination and treatment applications, due to its safety, efficacy and ease of use. This systematised review was designed to compile the current knowledge on the antimicrobial efficacy of 380-480 nm light on a range of healthcare and food related pathogens including vegetative bacteria, bacterial endospores, fungi and viruses. Data was compiled from 79 studies, with the majority focussing on wavelengths in the region of 405 nm...
January 19, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29350722/chemical-decontamination-of-ips-cell-derived-neural-cell-mixtures
#2
Di Mao, Xie Khim Watson Chung, Tomoko Andoh-Noda, Ying Qin, Shin-Ichi Sato, Yasushi Takemoto, Wado Akamatsu, Hideyuki Okano, Motonari Uesugi
This report describes the design and evaluation of phosphorylated 7-ethyl-10-hydroxycamptothecin (SN38-P), which selectively eliminates tumor-forming proliferative stem cells, including human induced pluripotent stem cells (hiPSCs) and neural stem cells, from iPSC-derived neural cell mixtures. Results of the present study demonstrate that simple phosphorylation of an anticancer drug can provide a safe, cost-effective, and chemically-defined tool for decontaminating hiPSC-derived neuron.
January 19, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29350117/-treating-poisoning-how-do-you-choose-the-best-type-of-gastrointestinal-decontamination
#3
M V Verschueren, F G A Jansman, D J Touw, C Kramers
- A new guideline: 'Intoxication: initial approach in the hospital' will be published this year. This guideline sets out the latest insights on gastrointestinal decontamination in intoxication; the advice is summarized in a flowchart.- The advice is to generally administer activated charcoal, unless there are indications that the toxin will not bind to activated charcoal or that the amount of toxin that the patient has ingested is too great; in these cases gastric lavage can be considered.- Activated charcoal can be administered up to 2 hours after the ingestion of a toxic substance, unless there are contra-indications...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29348551/designable-and-dynamic-single-walled-stiff-nanotubes-assembled-from-sequence-defined-peptoids
#4
Haibao Jin, Yan-Huai Ding, Mingming Wang, Yang Song, Zhihao Liao, Christina J Newcomb, Xuepeng Wu, Xian-Qiong Tang, Zheng Li, Yuehe Lin, Feng Yan, Tengyue Jian, Peng Mu, Chun-Long Chen
Despite recent advances in the assembly of organic nanotubes, conferral of sequence-defined engineering and dynamic response characteristics to the tubules remains a challenge. Here we report a new family of highly designable and dynamic nanotubes assembled from sequence-defined peptoids through a unique "rolling-up and closure of nanosheet" mechanism. During the assembly process, amorphous spherical particles of amphiphilic peptoid oligomers crystallize to form well-defined nanosheets before folding to form single-walled nanotubes...
January 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29341384/influence-of-spore-and-carrier-material-surface-hydrophobicity-on-decontamination-efficacy-with-condensing-hydrogen-peroxide-vapor
#5
Elisabeth Eschlbeck, Christina Seeburger, Ulrich Kulozik
AIMS: To investigate the influence of surface hydrophobicity of carrier material and bacterial spores of Bacillus subtilis SA 22 and Bacillus atrophaeus (DSM 675) on spore inactivation with condensing hydrogen peroxide gas. METHODS AND RESULTS: Surface hydrophobicity of bacterial spores and carrier material was determined by means of contact angle measurement. Spores of Bacillus subtilis showed water contact angles of 90 °, spores of Bacillus atrophaeus showed water contact angles of 42 °...
January 16, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29341288/lipid-and-nucleic-acid-chemistries-combining-the-best-of-both-worlds-to-construct-advanced-biomaterials
#6
REVIEW
Julie Baillet, Valérie Desvergnes, Aladin Hamoud, Laurent Latxague, Philippe Barthélémy
Hybrid synthetic amphiphilic biomolecules are emerging as promising supramolecular materials for biomedical and technological applications. Herein, recent progress in the field of nucleic acid based lipids is highlighted with an emphasis on their molecular design, synthesis, supramolecular properties, physicochemical behaviors, and applications in the field of health science and technology. In the first section, the design and the study of nucleolipids are in focus and then the glyconucleolipid family is discussed...
January 17, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29340947/the-impact-of-depuration-on-mussel-hepatopancreas-bacteriome-composition-and-predicted-metagenome
#7
J A Rubiolo, A Lozano-Leon, R Rodriguez-Souto, N Fol Rodríguez, M R Vieytes, L M Botana
Due to the rapid elimination of bacteria through normal behaviour of filter feeding and excretion, the decontamination of hazardous contaminating bacteria from shellfish is performed by depuration. This process, under conditions that maximize shellfish filtering activity, is a useful method to eliminate microorganisms from bivalves. The microbiota composition in bivalves reflects that of the environment of harvesting waters, so quite different bacteriomes would be expected in shellfish collected in different locations...
January 17, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29336224/treatment-of-a-klebsiella-pneumoniae-kpc-cellulitis-and-gut-decolonization-with-ceftazidime-avibactam-in-a-migrant-from-libya
#8
Novella Carannante, Carlo Pallotto, Mariano Bernardo, Giovanni Di Caprio, Carlo Tascini
KPC-producing Klebsiella pneumoniae (KPC-Kp) is nowadays a global concern. Ceftazidime/avibactam is the most promising novel antibiotic combination available at the moment. We describe the case of a migrant with no risk factors for an infection due to multidrug resistant bacteria. He suffered from a KPC-Kp cellulitis and was treated with a ceftazidime/avibactam-meropenem-fosfomycin combination that not only eradicated the infection but also decontaminated his gut. Ceftazidime/avibactam-based treatment can be useful also in decontamination procedures...
January 16, 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29334858/case-study-of-occupational-mercury-exposure-during-decontamination-of-turnaround-in-refinery-plant
#9
Maytiya Muadchim, Wantanee Phanprasit, Mark Gregory Robson, Dusit Sujirarat, Rawee Detchaipitak
Decontamination during turnaround (TA) can lead to high exposure to toxic chemicals among workers. The decontamination process in refinery plants usually comprises two types, i.e. steam and chemical decontamination. No matter the method used, concentrations of toxic chemicals must be measured using the direct reading instrument at the end of each decontamination cycle, which maybe repeated several times until the readings are in acceptable level. To evaluate mercury exposure of decontamination workers during decontamination procedure in comprehensive turnaround of a refinery plant...
January 15, 2018: International Journal of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29333698/design-of-enzyme-micelles-with-controllable-concavo-convex-micromorphologies-for-highly-enhanced-stability-and-catalytical-activity
#10
Tao Chen, Yuanhong Xu, Wenrong Yang, Aihua Li, Yao Wang, Jing Sun, Jingquan Liu
Concavo-convex micelles with controllable sizes and nanostructures are prepared via self-assembling polymer-enzyme (e.g., shellac enzyme) conjugates with heterogeneous polymer chains, which exhibit higher enzyme stability (300%) and bioactivity (760%) comparing with the well-defined ones. The applied amphiphilic and negatively charged copolymer, poly (methyl methacrylate)-block-poly (sodium p-styrene sulfonate), is synthesized via reversible addition-fragmentation chain transfer polymerization to modify shellac enzyme and immobilize the enzyme bioactivity inducer by covalent conjugation and electrostatic attraction, respectively...
January 15, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29332617/decontamination-of-extracorporeal-membrane-oxygenator-devices-with-an-intensified-disinfection-protocol-how-strict-is-too-strict
#11
Rami Sommerstein, Tobias M Merz, Stephan M Jakob, Jukka Takala, Jonas Marschall
No abstract text is available yet for this article.
January 15, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29331919/removal-of-pharmaceutical-pollutants-from-synthetic-wastewater-using-chemically-modified-biomass-of-green-alga-scenedesmus-obliquus
#12
Mohamed E M Ali, Azza M Abd El-Aty, Mohamed I Badawy, Rizka K Ali
Pharmaceutical compounds are considered emerging environmental pollutants that have a potential harmful impact on environment and human health. In this study, the biomass of alga (Scenedesmus obliquus) was modified using alkaline solution, and used for the biosorption of tramadol (TRAM) and other pharmaceuticals. The adsorption kinetics and isotherms were investigated. The obtained results reveal high adsorption capacity of tramadol over modified algal biomass (MAB) after 45min with removal percentage of 91%...
January 11, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29331341/effects-of-the-gut-liver-axis-on-ischemia-mediated-hepatocellular-carcinoma-recurrence-in-the-mouse-liver
#13
Lorenzo A Orci, Stéphanie Lacotte, Vaihere Delaune, Florence Slits, Graziano Oldani, Vladimir Lazarevic, Carlo Rossetti, Laura Rubbia-Brandt, Philippe Morel, Christian Toso
BACKGROUND & AIMS: There is growing evidence that liver graft ischemia-reperfusion (I/R) is a risk factor for hepatocellular carcinoma (HCC) recurrence, but the involved mechanisms are unclear. Here, we tested the hypothesis that mesenteric congestion due to portal blood flow interruption induces endotoxin-mediated Toll-Like Receptor 4 (Tlr4) engagement, resulting in elevated liver cancer burden. We also assessed the role of remote ischemic preconditioning (RIPC) in this context. METHODS: C57Bl/6j mice were exposed to standardized models of liver I/R injury and RIPC, by occluding hepatic and femoral blood vessels...
January 10, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29330188/germination-outgrowth-and-vegetative-growth-kinetics-of-dry-heat-treated-individual-spores-of-bacillus-species
#14
Lin He, Zhan Chen, Shiwei Wang, Muying Wu, Peter Setlow, Yong-Qing Li
DNA damage kills dry-heated spores of Bacillus subtilis, but dry heat-treatment effects on spore germination and outgrowth have not been studied. This is important, since if dry heat-killed spores germinate and undergo outgrowth, toxic proteins could be synthesized. Here, Raman spectroscopy and differential interference contrast microscopy were used to study germination and outgrowth of individual dry heat-treated B. subtilis and Bacillus megaterium spores. Major findings in this work were as follows. 1) Spores dry heat-treated at 140°C for 20 min nearly all lost viability but retained their Ca2+-dipicolinic acid (CaDPA) depot...
January 12, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29329231/development-of-a-cytocompatible-scaffold-from-pig-immature-testicular-tissue-allowing-human-sertoli-cell-attachment-proliferation-and-functionality
#15
Maxime Vermeulen, Federico Del Vento, Francesca de Michele, Jonathan Poels, Christine Wyns
Cryopreservation of immature testicular tissue before chemo/radiotherapy is the only option to preserve fertility of cancer-affected prepubertal boys. To avoid reintroduction of malignant cells, development of a transplantable scaffold by decellularization of pig immature testicular tissue (ITT) able to support decontaminated testicular cells could be an option for fertility restoration in these patients. We, therefore, compared decellularization protocols to produce a cytocompatible scaffold. Fragments of ITT from 15 piglets were decellularized using three protocols: sodium dodecyl sulfate (SDS)-Triton (ST), Triton-SDS-Triton (TST) and trypsin 0...
January 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29329120/re-osseointegration-of-dental-implants-after-periimplantitis-treatments-a-systematic-review
#16
Marwa Madi, Moe Htet, Osama Zakaria, Adel Alagl, Shohei Kasugai
PURPOSE: This review considers possible surgical treatment modalities for induced periimplantitis to regain re-osseointegration as reported in the recent literature. MATERIALS AND METHODS: Electronic searches in MEDLINE/PubMed and Google Scholar databases were performed on experimental studies considering induced periimplantitis and attempts to achieve re-osseointegration from 2003 up to December 2016. Conflicts about articles were solved by authors' discussion...
January 11, 2018: Implant Dentistry
https://www.readbyqxmd.com/read/29317001/video-based-learning-vs-traditional-lecture-for-instructing-emergency-medicine-residents-in-disaster-medicine-principles-of-mass-triage-decontamination-and-personal-protective-equipment
#17
Henry A Curtis, Karen Trang, Kevin W Chason, Paul D Biddinger
Introduction Great demands have been placed on disaster medicine educators. There is a need to develop innovative methods to educate Emergency Physicians in the ever-expanding body of disaster medicine knowledge. The authors sought to demonstrate that video-based learning (VBL) could be a promising alternative to traditional learning methods for teaching disaster medicine core competencies. Hypothesis/Problem The objective was to compare VBL to traditional lecture (TL) for instructing Emergency Medicine residents in the American College of Emergency Physicians (ACEP; Irving, Texas USA) disaster medicine core competencies of patient triage and decontamination...
January 10, 2018: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29316786/controlled-growth-and-grafting-of-high-density-au-nanoparticles-on-zinc-oxide-thin-films-by-photo-deposition
#18
Jeremy Cure, Hala Assi, Kévin Cocq, Lorena Marín, Katia Fajerwerg, Pierre Fau, Eric Beche, Yves J Chabal, Alain Esteve, Carole Rossi
The integration of high-purity nano-objects on substrates remains a great challenge for addressing scaling-up issues in nanotechnology. For instance, grafting gold nanoparticles (NPs) on zinc oxide films, a major step process for catalysis or photovoltaic applications, still remains difficult to master. We report a modified photo-deposition (P-D) approach that achieves tight control of the NPs size (7.5 ± 3 nm), shape (spherical), purity, and high areal density (3500 ± 10 NPs/m2) on ZnO films. This deposition method is also compatible with large ZnO surface areas...
January 9, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29315700/binding-affinity-and-decontamination-of-dermal-decontamination-gel-to-model-chemical-warfare-agent-simulants
#19
Yachao Cao, Akram Elmahdy, Hanjiang Zhu, Xiaoying Hui, Howard Maibach
Six chemical warfare agent simulants (trimethyl phosphate, dimethyl adipate, 2-chloroethyl methyl sulfide, diethyl adipate, chloroethyl phenyl sulfide and diethyl sebacate) were studied in in vitro human skin to explore relationship between dermal penetration/absorption and the mechanisms of simulant partitioning between stratum corneum (SC) and water as well as between dermal decontamination gel (DDGel) and water. Both binding affinity to and decontamination of simulants using DDGel were studied. Partition coefficients of six simulants between SC and water (Log PSC/w ) and between DDGel and water (Log PDDGel/w ) were determined...
January 7, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29311436/legionnaires-disease-as-an-occupational-risk-related-to-decontamination-work-after-the-fukushima-nuclear-disaster-a-case-report
#20
Toyoaki Sawano, Masaharu Tsubokura, Akihiko Ozaki, Claire Leppold, Shigeaki Kato, Toshiyuki Kambe
OBJECTIVES: Legionnaires' disease (LD), which is atypical pneumonia with a broad variety of clinical symptoms, can lead to death despite its low incidence. There are multiple risk factors for LD, yet little information is available concerning what kind of environmental factors are linked to higher risk of LD development. We have experienced a fatal case of LD, which occurred in a decontamination worker after the Fukushima nuclear disaster. CASE: A 53-year-old Japanese male visited our hospital with symptoms of fever, vomiting, diarrhea, and altered mental status, but not with respiratory manifestations...
December 28, 2017: Journal of Occupational Health
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