keyword
https://read.qxmd.com/read/38533375/comparative-efficacy-of-combined-antihistamine-and-montelukast-therapy-in-adult-patients-with-atopic-dermatitis
#1
JOURNAL ARTICLE
Kristina R Jamalyan, Helen G Azaryan
INTRODUCTION: Atopic dermatitis (AD) is one of the most common chronic skin conditions affecting about 20% of children and 5% of adults. However, the studies assessing novel therapies for AD have been focused mainly on paediatric patients and only few studies have involved adult participants. AIM: To compare the treatment outcomes between the antihistamine monotherapy and combined intervention with an antihistamine agent and a cysteinyl leukotriene receptor antagonist in adult patients with atopic dermatitis...
February 2024: Postȩpy Dermatologii i Alergologii
https://read.qxmd.com/read/38533280/evaluation-of-effect-of-montelukast-in-the-model-of-streptozotocin-induced-diabetic-nephropathy-in-rats
#2
JOURNAL ARTICLE
Dhananjay Kokate, Padmaja Marathe
BACKGROUND: Diabetic nephropathy is a progressive condition and a leading cause of end-stage renal disease. Oxidative stress and inflammation play an important role in its pathogenesis. In pre-clinical studies, Montelukast had shown renoprotective and anti-oxidant properties, hence the study was planned to evaluate the effect of Montelukast in a Streptozotocin (STZ) induced model of diabetic nephropathy. METHODS: 40 Wistar rats of either sex were randomly divided into four groups viz ...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38528652/the-contribution-of-the-wnt-pathway-to-the-therapeutic-effects-of-montelukast-in-experimental-murine-airway-inflammation-induced-by-ovalbumin-and-lipopolysaccharide
#3
JOURNAL ARTICLE
Yesim Kaya-Yasar, Seckin Engin, Elif Nur Barut, Cihan Inan, Ismail Saygin, Ilknur Erkoseoglu, Sena F Sezen
The wingless/integrase-1 (WNT) pathway involved in the pathogenesis of inflammatory airway diseases has recently generated considerable research interest. Montelukast, a leukotriene receptor antagonist, provides therapeutic benefits in allergic asthma involving eosinophils. We aimed to investigate the role of the WNT pathway in the therapeutic actions of montelukast (MT) in a mixed type of allergic-acute airway inflammation model induced by ovalbumin (OVA) and lipopolysaccharide (LPS) in mice. Female mice were sensitized with intraperitoneal OVA-Al(OH)3 administration in the initiation phase and intranasal OVA followed by LPS administration in the challenge phase...
April 2024: Drug Development Research
https://read.qxmd.com/read/38508226/ucomb-real-life-data-treatment-strategies-for-chronic-urticaria-patients-with-comorbidities
#4
JOURNAL ARTICLE
Petra Staubach, Benedikt Bilo, Joachim W Fluhr, Karoline Krause, Kanokvalai Kulthanan, Andac Salman, Connie Katelaris, Jonathan A Bernstein, Marcus Maurer, Caroline Mann
BACKGROUND: There is a lack of real-life safety data on treatment options for chronic urticaria in the presence of comedication and comorbidities. METHODS: We present a single-center UCARE pilot study of 212 outpatients with chronic urticaria. Patients were divided into three groups according to different CU therapies according to international guidelines. RESULTS: Of 212 patients, 108 (mean age 48.9 years, 71.3% female) had 59 comorbidities, including cardiovascular, autoimmune and malignant diseases...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38504551/a-review-of-the-therapeutic-potential-of-the-cysteinyl-leukotriene-antagonist-montelukast-in-the-treatment-of-bronchiolitis-obliterans-syndrome-following-lung-and-hematopoietic-stem-cell-transplantation-and-its-possible-mechanisms
#5
REVIEW
Nastaran Kordjazy, Shahideh Amini
Lung and hematopoietic stem cell transplantation are therapeutic modalities in chronic pulmonary and hematological diseases, respectively. One of the complications in these patients is the development of bronchiolitis obliterans syndrome (BOS). The efficacy and safety of available treatment strategies in BOS remain a challenge. A few mechanisms have been recognized for BOS in lung transplant and graft- versus -host disease (GVHD) patients involving the TH-1 and TH-2 cells, NF-kappa B, TGF-b, several cytokines and chemokines, and cysteinyl leukotrienes (CysLT)...
2024: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38501316/clinical-efficacy-of-montelukast-sodium-combination-therapy-for-cough-variant-asthma-in-children-a-meta-analysis
#6
REVIEW
Shihai Yang, Xia He, Rixia Zhang
This meta-analysis aims to assess the clinical effectiveness of combination therapy with montelukast sodium for the treatment of cough variant asthma (CVA) in children, intending to provide clinical evidence and data to guide the selection of clinical therapy. A literature review was conducted using numerous databases, including China National Knowledge Infrastructure (CNKI), Wanfang database, Embase, PubMed, and Web of Science, from inception to December 2023. Trials meeting the criteria for the combined treatment of montelukast sodium for CVA in children were included...
March 19, 2024: Pediatric Pulmonology
https://read.qxmd.com/read/38500132/four-chemometric-models-enhanced-by-latin-hypercube-sampling-design-for-quantification-of-anti-covid-drugs-sustainability-profiling-through-multiple-greenness-carbon-footprint-blueness-and-whiteness-metrics
#7
JOURNAL ARTICLE
Noha S Katamesh, Ahmed Emad F Abbas, Shimaa A Mahmoud
Montelukast sodium (MLK) and Levocetirizine dihydrochloride (LCZ) are widely prescribed medications with promising therapeutic potential against COVID-19. However, existing analytical methods for their quantification are unsustainable, relying on toxic solvents and expensive instrumentation. Herein, we pioneer a green, cost-effective chemometrics approach for MLK and LCZ analysis using UV spectroscopy and intelligent multivariate calibration. Following a multilevel multifactor experimental design, UV spectral data was acquired for 25 synthetic mixtures and modeled via classical least squares (CLS), principal component regression (PCR), partial least squares (PLS), and genetic algorithm-PLS (GA-PLS) techniques...
March 18, 2024: BMC chemistry
https://read.qxmd.com/read/38485149/ers-ebmt-clinical-practice-guideline-on-treatment-of-pulmonary-chronic-graft-versus-host-disease-in-adults
#8
JOURNAL ARTICLE
Saskia Bos, John Murray, Monia Marchetti, Guang-Shing Cheng, Anne Bergeron, Daniel Wolff, Clare Sander, Akshay Sharma, Sherif M Badawy, Zinaida Peric, Agnieszka Piekarska, Joseph Pidala, Kavita Raj, Olaf Penack, Samar Kulkarni, Molly Beestrum, Andrea Linke, Matthew Rutter, Courtney Coleman, Thomy Tonia, Hélène Schoemans, Daiana Stolz, Robin Vos
Chronic graft- versus -host disease (cGvHD) is a common complication after allogeneic haematopoietic stem cell transplantation, characterised by a broad disease spectrum that can affect virtually any organ. Although pulmonary cGvHD is a less common manifestation, it is of great concern due to its severity and poor prognosis. Optimal management of patients with pulmonary cGvHD is complicated and no standardised approach is available.The purpose of this joint European Respiratory Society and European Society for Blood and Marrow Transplantation Task Force was to develop evidence-based recommendations regarding the treatment of pulmonary cGvHD phenotype bronchiolitis obliterans syndrome in adults...
March 14, 2024: European Respiratory Journal
https://read.qxmd.com/read/38476566/effect-of-combination-montelukast-and-nasal-mometasone-on-childhood-adenoid-hypertrophy
#9
JOURNAL ARTICLE
Mohsen Jafari, Bahar Pourroshani, Kambiz Eftekhari, Armen Malekiantaghi, Parisa Ashournia, Alireza Shafiei
INTRODUCTION: Adenoid hypertrophy is a common childhood disease; its standard treatment is adenoidectomy. The desire for medical management is increasing due to fewer complications and more convenience. The present study investigated the effect of adding oral montelukast to mometasone nasal spray in treating adenoid hypertrophy. MATERIALS AND METHODS: This was a randomized, double-blind, placebo-controlled study conducted at a referral teaching hospital (Tehran, Iran) from September 2020 to September 2021...
March 2024: Iranian Journal of Otorhinolaryngology
https://read.qxmd.com/read/38460418/pharmacological-interventions-for-pediatric-obstructive-sleep-apnea-osa-network-meta-analysis
#10
REVIEW
Yuxiao Zhang, Siqi Leng, Qian Hu, Yingna Li, Yumeng Wei, You Lu, Di Qie, Fan Yang
IMPORTANCE: Pediatric obstructive sleep apnea (OSA) is a common disease that can have significant negative impacts on a child's health and development. A comprehensive evaluation of different pharmacologic interventions for the treatment of OSA in children is still lacking. OBJECTIVE: This study aims to conduct a comprehensive systematic review and network meta-analysis of pharmacological interventions for the management of obstructive sleep apnea in pediatric population...
February 6, 2024: Sleep Medicine
https://read.qxmd.com/read/38455695/eosinophilic-gastroenteritis-following-covid-19-mrna-vaccination
#11
JOURNAL ARTICLE
Yuta Yoshino, Ken Tsuboi
INTRODUCTION: Large-scale clinical studies for COVID-19 vaccines have shown the infection-preventing effect and short-term adverse effects. Some rare illnesses such as eosinophilia can develop following COVID-19 vaccinations. CASE DESCRIPTION: We report a case of 65-year-old man with unexplained abdominal pain that developed 2 weeks after COVID-19 mRNA vaccination. The patient had received a second dose of COVID-19 mRNA vaccine and revealed eosinophilia at the first visit to our hospital...
2024: European Journal of Case Reports in Internal Medicine
https://read.qxmd.com/read/38443098/montelukast-regulator-reviewing-asthma-drug-over-concerns-about-mental-health-effects
#12
JOURNAL ARTICLE
Elisabeth Mahase
No abstract text is available yet for this article.
March 5, 2024: BMJ: British Medical Journal
https://read.qxmd.com/read/38442638/comparison-of-treatment-efficacy-of-omega-3-fish-oil-and-montelukast-in-ovalbumin-protease-induced-allergic-rhinitis-model-in-rats
#13
JOURNAL ARTICLE
Alper Tabaru, Sahin Ogreden, Salih Akyel, Mehmet Faruk Oktay, Kemal Uslu, Funda Kaya Emre
OBJECTIVES: Montelukast is a well-known leukotriene receptor antagonist commonly used in treating allergic rhinitis and asthma. Omega-3 fatty acid is also known as an antiallergic and immunomodulator molecule. This study aimed to elucidate the efficacy of systemic montelukast and omega-3 fatty acid treatment in allergic rhinitis models in Wistar Hannover rats. METHODS: This research was conducted on 28 healthy Wistar Hannover rats weighing 250-350 g. After establishing the allergic rhinitis model, nasal symptoms were observed and scored, and the nasal mucosa of all rats was investigated histologically...
February 21, 2024: Brazilian Journal of Otorhinolaryngology
https://read.qxmd.com/read/38337010/montelukast-an-available-and-safe-anti-asthmatic-drug-prevents-maladaptive-remodelling-and-maintains-cardiac-functionality-following-myocardial-infarction
#14
JOURNAL ARTICLE
Majeda Muluhie, Laura Castiglioni, Joanna Rzemieniec, Benedetta Mercuriali, Paolo Gelosa, Luigi Sironi
Preclinical and clinical data indicate that the 5-lipoxygenase pathway becomes activated in cardiovascular diseases suggesting an important role of CysLTs in atherosclerosis and in its ischemic complications. This study aims to investigate the effects of montelukast, a CysLTR-1 antagonist, in a mouse model of myocardial infarction (MI). C57BL/6N female mice were subjected to coronary artery ligation and received montelukast (10 mg/kg/day, intraperitoneal) or vehicle. Montelukast exerted beneficial effects in the infarcted area, decreasing mRNA expression of inflammatory genes, such Il1β and Ccl2 (p < 0...
February 9, 2024: Scientific Reports
https://read.qxmd.com/read/38332955/public-interest-in-montelukast-prior-to-and-after-announcement-of-black-box-warning-and-associations-with-adverse-event-reports
#15
JOURNAL ARTICLE
Samer Abdelkader, Micah Hartwell, Amy D Hendrix-Dicken, Michelle Escala, Michelle Condren
No abstract text is available yet for this article.
2024: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/38306389/effect-of-montelukast-in-preventing-dengue-with-warning-signs-among-patients-with-dengue-a-multicenter-randomized-double-blind-placebo-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Nattapat Nitinai, Worapong Nasomsong, Worayon Chuerboonchai, Akarawin Tweekittikul, Vutthikorn Khingmontri, Bawornnan Panuvatvanich, Thananut Bangchuad, Maynanchaya Pongpraijaroen, Tanapol Roongfa-Ngarm, Vasin Vasikasin
BACKGROUND: Montelukast has shown potential as a candidate treatment for dengue. This study aimed to evaluate the efficacy and safety of montelukast in preventing dengue with warning signs. METHODS: This multicenter, randomized, double-blind, placebo-controlled trial enrolled adult participants with NS1 antigenemia in Thailand. The participants were randomly assigned to receive either oral montelukast (10 mg) or a placebo for 10 days or until all symptoms resolved...
February 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38304615/computational-screening-of-biomarkers-and-potential-drugs-for-arthrofibrosis-based-on-combination-of-sequencing-and-large-nature-language-model
#17
JOURNAL ARTICLE
Xi Chen, Cheng Li, Ziyuan Wang, Yixin Zhou, Ming Chu
BACKGROUND: Arthrofibrosis (AF) is a fibrotic joint disease resulting from excessive collagen production and fibrous scar formation after total knee arthroplasty (TKA). This devastating complication may cause consistent pain and dramatically reduction of functionality. Unfortunately, the conservative treatments to prevent the AF in the early stage are largely unknown due to the lack of specific biomarkers and reliable therapeutic targets. METHODS: In this study, we extracted1782 fibrosis related genes (FRGs) from 373,461published literature based on the large natural language processing models (ChatGPT) and intersected with the 2750 differential expressed genes (DEGs) from mRNA microarray (GSE135854)...
January 2024: Journal of Orthopaedic Translation
https://read.qxmd.com/read/38303771/a-48-year-old-man-with-a-hip-fracture-and-skin-rash-a-case-report
#18
J Anthony Parker, Runhua Hou
BACKGROUND/OBJECTIVE: Patients with systemic mastocytosis are at high risk of developing osteoporosis and fractures. Herein, we report a case of hip fragility fracture in a patient with indolent systemic mastocytosis and normal bone density. CASE REPORT: A 48-year-old man experienced a left femoral neck fracture after a fall. After a dose of oxycodone/hydromorphone postoperatively, he developed an anaphylactic reaction. Previously, he experienced a few other episodes of flushing, dizziness, and syncope precipitated by stress and alcohol...
2024: AACE Clinical Case Reports
https://read.qxmd.com/read/38300251/the-landscape-of-very-important-pharmacogenes-variants-and-potential-clinical-relevance-in-the-chinese-jingpo-population-a-comparative-study-with-worldwide-populations
#19
JOURNAL ARTICLE
Xiaoya Ma, Yujie Li, Xufeng Zang, Jinping Guo, Wenqian Zhou, Junhui Han, Jing Liang, Panpan Wan, Hua Yang, Tianbo Jin
BACKGROUND: Pharmacogenomics is a facet of personalized medicine that explores how genetic variants affect drug metabolism and adverse drug reactions. Therefore, this study aims to detect distinct pharmacogenomic variations among the Jingpo population and explore their clinical correlation with drug metabolism and toxicity. METHODS: Agena MassARRAY Assay was used to genotype 57 VIP variants in 28 genes from 159 unrelated Jingpo participants. Subsequently, the chi-squared test and Bonferroni's statistical tests were utilized to conduct a comparative analysis of genotypes and allele frequencies between the Jingpo population and the other 26 populations from the 1000 Genome Project...
February 1, 2024: Cancer Chemotherapy and Pharmacology
https://read.qxmd.com/read/38298631/anti-enzymatic-and-dna-docking-studies-of-montelukast-a-multifaceted-molecular-scaffold-with-in-vitro-investigations-molecular-expression-analysis-and-molecular-dynamics-simulations
#20
JOURNAL ARTICLE
Shawana Abdullah, Ambar Iqbal, Avinash Karkada Ashok, Farah Chafika Kaouche, Misbah Aslam, Safdar Hussain, Jameel Rahman, Muhammad Munawar Hayat, Muhammad Ashraf
Montelukast, an approved leukotriene receptor 1 (Cys-LT 1) antagonist with anti-inflammatory properties is used for the treatment of asthma and allergic rhinitis. In the present studies, montelukast was subjected to in vitro inhibitory assays followed by kinetic and in silico investigations. Montelukast demonstrated inhibitory activity against yeast α-glucosidase (IC50 44.31 ± 1.21 μM), jack bean urease (JB urease, IC50 8.72 ± 0.23 μM), human placental alkaline phosphatase (hPAP, IC50 17...
January 30, 2024: Heliyon
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