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https://www.readbyqxmd.com/read/29331588/antagonism-of-cysteinyl-leukotriene-receptor-1-cysltr1-by-montelukast-suppresses-cell-senescence-of-chondrocytes
#1
Wei Song, Yumin Zhang, Jun Wang, Tao Ma, Linjie Hao, Kunzheng Wang
Aging is closely associated with osteoarthritis (OA). Although its underlying mechanisms remain unknown, cellular senescence in chondrocytes has become an important therapeutic target for the treatment of OA. Cysteinyl leukotriene receptors (cysLTRs) mediate the pathobiological function of cysteinyl leukotrienes (cysLTs). However, the roles of cysLTRs in the pathogenesis of OA have not been reported before. In the current study, we found that cysLTR1 but not cysLTR2 is expressed in human primary chondrocytes...
January 10, 2018: Cytokine
https://www.readbyqxmd.com/read/29319028/comparison-of-oral-montelukast-with-oral-ozagrel-in-acute-asthma-a-randomized-double-blind-placebo-controlled-study
#2
Rahul Magazine, Vyshak Uddur Surendra, Bharti Chogtu
BACKGROUND: The need for more effective management of acute asthma has led to research on drugs which are otherwise approved for use in chronic asthma. OBJECTIVE: To study and compare the effects of oral montelukast with oral ozagrel in acute asthma. MATERIALS AND METHODS: One hundred and twenty patients with acute asthma were recruited for the study. Out of 120 study patients, forty each were randomized into placebo, montelukast, and ozagrel groups...
January 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29312540/cyslt1-receptor-antagonist-alleviates-pathogenesis-of-collagen-induced-arthritis-mouse-model
#3
Minwen Xu, Ruiyun Hong, Xiaoli Zhang, Hailin Zou, Yi Zhang, Zhiping Hou, Liefeng Wang
Cysteinyl leukotrienes (CysLTs) play a key role in inflammatory diseases such as asthma and their receptors' antagonists are currently used as anti-asthmatic drugs. CysLTs have also been found to participate in other inflammatory reactions. Here, we reported that in rheumatoid arthritis (RA) animals model, collagen-induced arthritis, (CIA), CysLT1, a receptor for CysLTs, was up-regulated in hind paw and lymph node, while CysLTs levels in the blood were also higher than normal mice. Montelukast, a drug targeting CysLT1, has been shown to effectively reduce the CIA incidence, peak severity, and cumulative disease scores...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29308548/management-of-recurrent-preschool-doctor-diagnosed-wheeze
#4
REVIEW
Ka-Ka Siu, Shuk-Yu Leung, Sum-Yi Kong, Daniel Kwok-Keung Ng
Preschool wheeze occurs in half of the children before they reach 6 y of age and recurrence is also common. Recurrent preschool wheeze is classified as either typical or atypical. For typical recurrent preschool wheeze, the diagnoses are either asthma or bronchiolitis/bronchitis. Responsiveness to a properly administered bronchodilator confirms asthma, atopic or otherwise. All atypical preschool wheeze should be referred to pediatric respirologist for assessment. Lung function test by impulse oscillometry (IOS) before and after bronchodilator is helpful to confirm airway hyperresponsiveness, an essential feature of asthma...
January 8, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29306232/evaluation-of-the-effects-of-montelukast-mometasone-furoate-and-combined-therapyon-adenoid-size-a-randomized-prospective-clinical-trial-with-objective-data
#5
Birgül Tuhanıoğlu, Sanem Okşan Erkan
Background/aim: The incidence of adenoid hypertrophy is 2%-3% in children. Adenoidectomy is a commonly performed procedure in children that may cause complications such as early or late bleeding (4%-5%), recurrence of adenoid tissue (10%-20%), and postoperative respiratory problems (27%). Therefore, medical therapy alternatives to adenoidectomy are important and must be tried before surgery. In this study, we investigated the efficacy of mometasone furoate, montelukast, and a combination of these drugs in pediatric patients with adenoid hypertrophy who were scheduled for reduction with medical therapy after not being recommended for surgery...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29248523/emerging-therapies-for-atopic-dermatitis-the-prostaglandin-leukotriene-pathway
#6
Daniel A Yanes, Joy L Mosser-Goldfarb
The role of leukotrienes and prostaglandins in development of atopy has been prototypically established in studies of asthma pathogenesis. Likewise, both in vitro and in vivo studies of atopic dermatitis have demonstrated that these molecules maintain important pathophysiologic roles. Thus, it follows that targeted therapies against these molecules may be promising in management of atopic dermatitis. Montelukast has had questionable efficacy in patients with atopic dermatitis, while small pilots using zileuton did have some clinically significant improvement...
December 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29231431/-micro-invasive-embedding-combined-with-montelukast-sodium-for-children-cough-variant-asthma-a-randomized-controlled-trial
#7
Xiaoyan Wang, Baoqin Liu, Bin Lu, Yanmei Zhang, Liran Wang, Haijin Li, Xue Han, Dan Ding
OBJECTIVE: To observe the effects of micro-invasive embedding combined with montelukast sodium and simple montelukast sodium for children cough variant asthma (CVA). METHODS: A total of 240 patients were randomly assigned into an observation group and a control group, 120 cases in each one. Considering of cases dropping, 101 patients in the observation group and 105 cases in the control group were included. Montelukast sodium chewable tablets were applied before sleep for 3 months in the control group, 5 mg a time, once a day...
March 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29218228/similar-adverse-events-from-two-disparate-agents-implicate-lipid-inflammatory-mediators-for-a-role-in-anxiety-states
#8
Gordon C McCarter, Lauren B Blanchard
We recently reported a case in which a 54-year-old male experienced maintenance insomnia, generalized anxiety and panic symptoms associated with consumption of a fish oil supplement enriched in eicosapentaenoic acid (EPA). We report here that the same patient has experienced identical but more severe symptoms in response to the use of the leukotriene receptor antagonist montelukast, in accordance with other cases reported to the Food and Drug Administration. Since omega-3 fatty acids like EPA are precursors for the biosynthesis of eicosanoids including leukotrienes, a common factor to these psychiatric adverse events may be perturbations in this highly complex system of lipid inflammatory mediators...
November 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29205659/role-of-montelukast-in-management-of-episodic-viral-wheeze
#9
Tristan W Harding, Anton Gm Harding
No abstract text is available yet for this article.
December 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29201275/resveratrol-and-montelukast-alleviate-paraquat-induced-hepatic-injury-in-mice-modulation-of-oxidative-stress-inflammation-and-apoptosis
#10
Noha A El-Boghdady, Nourtan F Abdeltawab, Mohammed M Nooh
Paraquat (PQ) is one of the most used herbicide worldwide. Its cytotoxicity is attributed to reactive radical generation. Resveratrol (Res) and montelukast (MK) have anti-inflammatory and antioxidant properties. The protective effects of Res, MK, or their combination against PQ-induced acute liver injury have not been investigated before. Therefore, we explored the protective potential of Res and/or MK against PQ hepatic toxicity in a mouse model. Mice were randomly assigned to five groups: group I served as the normal control and group II received a single dose of PQ (50 mg/kg, i...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29188782/pharmacokinetic-behavior-of-montelukast-in-indigenous-healthy-male-volunteers
#11
Amtul Fayyaz, Junaid Ali Khan, Muhammad Mudassar Ashraf, Naheed Akhter, Bilal Aslam, Muhammad Fiaz Khalid, Sidra Altaf, Rana Dawood Naseer, Muhammad Akram, Syed Muhammad Ali Shah, Muhammad Waqas Khadam, Imtiaz Mahmood Tahir
Aim of present study was to investigate the pharmacokinetic behavior of Montelukast in the healthy male volunteers under indigenous conditions. One tablet of montelukast 10 mg was administered in each subject and blood at different time intervals. Concentration of montelukast in plasma samples was analyzed by high performance liquid chromatography method to calculate pharmacokinetic parameters. The plasma concentration of montelukast was in the range of 1.31-1.76μg/mL at 0.5-12 hours with Cmax value of 1.59±0...
November 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29184413/near-fatal-asthma-responsive-to-mepolizumab-after-failure-of-omalizumab-and-bronchial-thermoplasty
#12
Francesco Menzella, Carla Galeone, Mirco Lusuardi, Anna Simonazzi, Claudia Castagnetti, Patrizia Ruggiero, Nicola Facciolongo
Severe asthma affects between 5% and 10% of patients with asthma worldwide and requires best standard therapies at maximal doses, but there is a subgroup of patients refractory to all treatments. We share a case report of a 53-year-old woman with a history of severe allergic asthma that progressively worsened over the years despite the best therapy. She had been hospitalized 35 times, including nine admissions to the respiratory intensive care unit due to severe exacerbations. To rule out other possible diagnoses, several investigations were performed, such as computed tomography scan of the chest and neck, fiberoptic laryngoscopy, antineutrophil cytoplasmic antibodies, and complete blood cell count...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29171020/clopidogrel-but-not-prasugrel-significantly-inhibits-the-cyp2c8-mediated-metabolism-of-montelukast-in-humans
#13
Matti K Itkonen, Aleksi Tornio, Anne M Filppula, Mikko Neuvonen, Pertti J Neuvonen, Mikko Niemi, Janne T Backman
The oxidation of montelukast is mainly mediated by cytochrome P450 (CYP) 2C8, but other mechanisms may contribute to its disposition. In healthy volunteers, we investigated the effects of two widely used P2Y12 inhibitors on montelukast pharmacokinetics. Clopidogrel (300 mg on day 1 and 75 mg on day 2) increased the area under the plasma concentration-time curve (AUC) of montelukast 2.0-fold (90% confidence interval (CI) 1.72-2.28, P < 0.001) and decreased the M6:montelukast AUC0-7h ratio to 45% of control (90% CI 40-50%, P < 0...
November 24, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29114905/leukotriene-receptor-antagonism-may-not-be-effective-in-atopic-dermatitis-treatment-after-all
#14
W K Chin
WHAT IS KNOWN AND OBJECTIVE: Literature evidence suggests leukotriene involvement in the pathogenesis of atopic dermatitis. This article aimed to discuss whether the off-label use of montelukast, a leukotriene receptor antagonist, is justifiable for the treatment of atopic dermatitis. COMMENT: Most non-randomized studies supported the use of montelukast for atopic dermatitis treatment. However, evidence from these studies should be interpreted with caution as it is relatively weak due to the absence of randomization, control groups and blinding processes, subjecting the results to high risk of selection and reporting biases...
February 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29114894/lack-of-long-term-add-on-effect-by-montelukast-in-postoperative-chronic-rhinosinusitis-patients-with-nasal-polyps
#15
Laura Van Gerven, Cristobal Langdon, Arturo Cordero, Sara Cardelús, Joaquim Mullol, Isam Alobid
OBJECTIVES/HYPOTHESIS: Eosinophils and mast cells are among the key cells in inflammatory diseases like chronic rhinosinusitis (CRS) and asthma. Leukotriene antagonists have proven to be effective in the treatment of asthma, but data about their efficacy in CRS are scarce, whereas data on montelukast as an add-on treatment to intranasal corticosteroids (INCS) in a postoperative setting are completely lacking. STUDY DESIGN: Prospective, randomized, open-label trial...
November 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29090647/response-to-in-reference-to-the-effect-of-montelukast-on-mild-persistent-osa-after-adenotonsillectomy-in-children-a-preliminary-study
#16
Bing Wang, Jia Liang
No abstract text is available yet for this article.
November 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29090646/in-reference-to-the-effect-of-montelukast-on-mild-persistent-osa-after-adenotonsillectomy-in-children-a-preliminary-study
#17
Hyun Jin Min, Kyung Soo Kim
No abstract text is available yet for this article.
November 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29079387/management-of-allergic-rhinitis-a-review-for-the-community-pharmacist
#18
REVIEW
J Russell May, William K Dolen
PURPOSE: Allergic rhinitis is a highly prevalent disease affecting the quality of life of millions of North Americans. The management of allergic rhinitis includes allergen avoidance, pharmacotherapy, and immunotherapy. Current pharmacologic options include oral and intranasal antihistamines, intranasal corticosteroids, oral and intranasal decongestants, oral and intranasal anticholinergics, and leukotriene receptor antagonists. Second-generation oral antihistamines and intranasal corticosteroids are the mainstays of treatment, with practice guidelines recommending intranasal corticosteroids as first-line treatment for moderate to severe allergic rhinitis...
October 24, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29076063/neuropsychiatric-events-associated-with-leukotriene-modifying-agents-a-systematic-review
#19
REVIEW
Sharon W Y Law, Angel Y S Wong, Shweta Anand, Ian C K Wong, Esther W Chan
INTRODUCTION: Leukotriene-modifying agents (LTMAs) including montelukast, zafirlukast, and zileuton are approved by the US Food and Drug Administration (FDA) for the treatment of asthma and allergic rhinitis. Various neuropsychiatric events (NEs) have been reported; however, the evidence of the association is conflicting. This systematic review investigates the association between NEs and LTMAs by assessing the relevant published literature. METHODS: PubMed, EMBASE, MEDLINE, and Cochrane Library were searched using keywords...
October 26, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29070274/long-term-omalizumab-use-in-the-treatment-of-exercise-induced-anaphylaxis
#20
Mark R Peterson, Christopher A Coop
Reported is a case of a 39-year-old male who was diagnosed with exercise-induced anaphylaxis (EIA). He was initially treated prophylactically with fexofenadine, montelukast, and ranitidine. He also used an epinephrine autoinjector as needed. He was refractory to these medications and continued to have episodes of EIA. He was then started on a trial of omalizumab, an immunoglobulin E monoclonal antibody, and had resolution of the EIA episodes. After discontinuation of the omalizumab, the EIA episodes returned...
October 1, 2017: Allergy & Rhinology
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