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Cardiovascular disease model

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https://www.readbyqxmd.com/read/28239641/macrovascular-and-microvascular-cerebral-blood-flow-in-adults-at-risk-for-alzheimer-s-disease
#1
Lindsay R Clark, Sara E Berman, Leonardo A Rivera-Rivera, Siobhan M Hoscheidt, Burcu F Darst, Corinne D Engelman, Howard A Rowley, Cynthia M Carlsson, Sanjay Asthana, Patrick Turski, Oliver Wieben, Sterling C Johnson
INTRODUCTION: Capillary hypoperfusion is reported in asymptomatic adults at-risk for Alzheimer's disease (AD), but the extent that can be explained by reduced flow in intracranial arteries is unknown. METHODS: One hundred fifty-five asymptomatic adults enriched for AD risk (mean age 61 years) completed arterial spin labeling (pcASL) and 4D-flow MRI sequences. Voxel-wise regression models investigated the relationship between mean flow in bilateral cerebral arteries and capillary perfusion, and tested potential moderators of this relationship...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28238606/comparison-of-associations-of-dxa-and-ct-visceral-adipose-tissue-measures-with-insulin-resistance-lipid-levels-and-inflammatory-markers
#2
John T Schousboe, Lisa Langsetmo, Ann V Schwartz, Brent C Taylor, Tien N Vo, Allyson M Kats, Elizabeth Barrett-Connor, Eric S Orwoll, Lynn M Marshall, Iva Miljkovic, Nancy E Lane, Kristine E Ensrud
Visceral adipose tissue (VAT) measured by computed tomography (CT) is related to insulin resistance, lipids, and serum inflammatory markers. Our objective was to compare the strength of the associations of VAT measured using dual-energy X-ray absorptiometry (DXA-VAT) and CT (CT-VAT) with insulin resistance, serum lipids, and serum markers of inflammation. For 1117 men aged 65 and older enrolled in the Osteoporotic Fractures in Men Study, the cross-sectional associations of DXA-VAT and CT-VAT with homeostasis model assessment of insulin resistance (homa2ir), C-reactive protein, and high-density lipoprotein (HDL) cholesterol were estimated with regression models and compared using a Hausman test...
February 23, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28237973/modulatory-effects-of-melatonin-and-vitamin%C3%A2-%C3%A2-c-on-oxidative-stress-mediated-haemolytic-anaemia-and-associated-cardiovascular-dysfunctions-in-rats
#3
Temitayo Olabisi Ajibade, Ademola Adetokunbo Oyagbemi, Ladoke A Durotoye, Temidayo Olutayo Omóbòwálé, Ebunoluwa Racheal Asenuga, Funsho Olakitike Olayemi
Background Phenylhydrazine (PHE) in experimental animal models has been widely reported to cause haemolytic anaemia, via the induction of oxidative stress and thus causing deleterious cardiovascular complications. Hence, this study was designed to evaluate the possible modulatory role of melatonin (MLT) or vitamin C when co-administered with PHE. Methods Anaemia was established with PHE administration. MLT or vitamin C was co-administered with PHE. Haematological parameters, markers of oxidative stress, enzymic and non-enzymic antioxidants, blood pressure and electrocardiograms were assessed...
February 25, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28237309/impact-of-climate-change-on-heat-related-mortality-in-jiangsu-province-china
#4
Kai Chen, Radley M Horton, Daniel A Bader, Corey Lesk, Leiwen Jiang, Bryan Jones, Lian Zhou, Xiaodong Chen, Jun Bi, Patrick L Kinney
A warming climate is anticipated to increase the future heat-related total mortality in urban areas. However, little evidence has been reported for cause-specific mortality or nonurban areas. Here we assessed the impact of climate change on heat-related total and cause-specific mortality in both urban and rural counties of Jiangsu Province, China, in the next five decades. To address the potential uncertainty in projecting future heat-related mortality, we applied localized urban- and nonurban-specific exposure response functions, six population projections including a no population change scenario and five Shared Socioeconomic Pathways (SSPs), and 42 temperature projections from 21 global-scale general circulation models and two Representative Concentration Pathways (RCPs)...
February 22, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28237179/translating-the-biology-of-adipokines-in-atherosclerosis-and-cardiovascular-diseases-gaps-and-open-questions
#5
REVIEW
M Ruscica, A Baragetti, A L Catapano, G D Norata
AIM: Critically discuss the available data, to identify the current gaps and to provide key concepts that will help clinicians in translating the biology of adipokines in the context of atherosclerosis and cardio-metabolic diseases. DATA SYNTHESIS: Adipose tissue is nowadays recognized as an active endocrine organ, a function related to the ability to secrete adipokines (such as leptin and adiponectin) and pro-inflammatory cytokines (tumor necrosis factor alpha and resistin)...
December 23, 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28236917/outcomes-of-native-superficial-femoral-artery-chronic-total-occlusion-recanalization-after-failed-femoropopliteal-bypass
#6
Mark G Davies, Hosam F El-Sayed
OBJECTIVE: When a bypass fails, the options are lysis, redo bypass, or endovascular intervention. If lysis of the original bypass is not considered an option, which is better-redo bypass or attempts at endovascular recanalization of the native system? This retrospective study examined the outcomes of native superficial femoral artery (SFA) chronic total occlusion (CTO) recanalization compared with redo bypass after failed femoropopliteal bypass. METHODS: Patients presenting with a symptomatic failed femoropopliteal bypass that underwent attempted CTO endovascular (EV) recanalization of the native SFA or a redo femoropopliteal bypass (BP) from 2000 to 2015 were analyzed...
March 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28236703/rgd-modified-and-pegylated-lipid-nanoparticles-loaded-with-puerarin-formulation-characterization-and-protective-effects-on-acute-myocardial-ischemia-model
#7
Zhaoqiang Dong, Jing Guo, Xiaowei Xing, Xuguang Zhang, Yimeng Du, Qinghua Lu
CONTEXT: Puerarin has been widely used as a therapeutic agent for the treatment of cardiovascular diseases. However, its rapid elimination half-life in plasma and poor water solubility limits its clinical efficacy. OBJECTIVE: RGD modified and PEGylated solid lipid nanoparticles loaded with puerarin (RGD/PEG-PUE-SLN) were developed to improve bioavailability of PUE, to prolong retention time in vivo and to enhance its protective effect on acute myocardial ischemia model...
February 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28236330/contesting-lifestyle-risk-and-gendering-coronary-candidacy-lay-epidemiology-of-heart-disease-in-finland-in-the-1970s
#8
Mikko Jauho
This study addresses two issues currently under critical discussion in the epidemiology of cardiovascular diseases (CVD), the relative neglect of women and the individualised nature of key risk factors. It focuses on the North Karelia project (NKP), a community programme aimed at coronary heart disease (CHD) prevention in a predominantly rural Finnish region in the early 1970s, that is, during a period when the epidemiological understanding of CVD still was relatively new and actively promoted. Adopting the notions of lay epidemiology and coronary candidacy, culturally mediated explanatory models lay people use to assess who is likely to develop heart disease and why, the study shows that locals targeted by the project critically engaged with both of these bias...
February 24, 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/28236138/progression-of-kidney-disease-in-elderly-stage-3-and-4-chronic-kidney-disease-patients
#9
Pradeep Arora, Kabir Jalal, Anu Gupta, Randolph L Carter, James W Lohr
PURPOSE: The prevalence of chronic kidney disease (CKD) has been rising steadily in the elderly population. We studied the rate of progression of CKD in this population and the factors associated with progression of CKD to better identify patients who are likely to progress to ESRD. METHODS: This was an observational study including 4562 patients older than 65 years with two outpatient estimated glomerular filtration rates (eGFRs) of <60 ml/min/1.73 m(2), at least 90 days apart with no intervening eGFR >60 ml/min/1...
February 24, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28235819/does-the-risk-of-hospitalisation-for-ischaemic-heart-disease-rise-already-before-widowhood
#10
Elina Einiö, Heta Moustgaard, Pekka Martikainen, Taina Leinonen
BACKGROUND: The death of a spouse has been shown to increase mortality from various causes, including ischaemic heart disease. It is unclear, however, whether cardiac problems are already on the rise before widowhood. METHODS: Using longitudinal register data of Finnish widows-to-be aged 65 and over at baseline (N=19 185), we assessed the risk of hospitalisation for ischaemic heart disease 18 months before and after widowhood. Hospital admissions were derived from national hospital discharge registers between 1996 and 2002...
February 24, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28235781/pathogenesis-of-depression-and-anxiety-like-behavior-in-an-animal-model-of-hypertrophic-cardiomyopathy
#11
Amanda M Dossat, Marcos A Sanchez-Gonzalez, Andrew P Koutnik, Stefano Leitner, Edda L Ruiz, Brittany Griffin, Jens T Rosenberg, Samuel C Grant, Francis D Fincham, Jose R Pinto, Mohamed Kabbaj
Cardiovascular dysfunction is highly comorbid with mood disorders, such as anxiety and depression. However, the mechanisms linking cardiovascular dysfunction with the core behavioral features of mood disorder remain poorly understood. In this study, we used mice bearing a knock-in sarcomeric mutation, which is exhibited in human hypertrophic cardiomyopathy (HCM), to investigate the influence of HCM over the development of anxiety and depression. We employed behavioral, MRI, and biochemical techniques in young (3-4 mo) and aged adult (7-8 mo) female mice to examine the effects of HCM on the development of anxiety- and depression-like behaviors...
February 24, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28235776/cost-effectiveness-of-a-text-message-programme-for-the-prevention-of-recurrent-cardiovascular-events
#12
Edward Burn, Son Nghiem, Stephen Jan, Julie Redfern, Anthony Rodgers, Aravinda Thiagalingam, Nicholas Graves, Clara K Chow
OBJECTIVE: To estimate the cost-effectiveness of Tobacco, Exercise and Diet Messages (TEXT ME), a text message-based intervention that provides advice, motivation, information and support to improve health-related behaviours. METHODS: A lifetime Markov model was used to estimate major vascular events (myocardial infarctions and strokes) avoided, quality-adjusted life years (QALYs) gained, costs to the health system and the incremental cost per QALY gained. The model was informed by data from a randomised controlled trial of TEXT ME, with evidence from systematic reviews and meta-analyses used to estimate the effects of changes in risk factors on the risk of major vascular events...
February 24, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28235613/impaired-hepatic-lipid-synthesis-from-polyunsaturated-fatty-acids-in-tm6sf2-e167k-variant-carriers-with-nafld
#13
Panu K Luukkonen, You Zhou, P A Nidhina Haridas, Om P Dwivedi, Tuulia Hyötyläinen, Ashfaq Ali, Anne Juuti, Marja Leivonen, Taru Tukiainen, Linda Ahonen, Emma Scott, Jeremy M Palmer, Johanna Arola, Marju Orho-Melander, Petter Vikman, Quentin M Anstee, Vesa M Olkkonen, Matej Orešič, Leif Groop, Hannele Yki-Järvinen
BACKGROUND: Carriers of the transmembrane 6 superfamily member 2 E167K gene variant (TM6SF2(EK/KK)) have decreased expression of the TM6SF2 gene and increased risk of NAFLD and NASH. Unlike common 'obese/metabolic' NAFLD, these subjects lack hypertriglyceridemia and have lower risk of cardiovascular disease. In animals, phosphatidylcholine (PC) deficiency results in a similar phenotype. PCs surround the core of VLDL consisting of triglycerides (TGs) and cholesteryl-esters (CEs). We determined the effect of the TM6SF2 E167K on these lipids in the human liver and serum and on hepatic gene expression and studied the effect of TM6SF2 knockdown on hepatocyte handling of these lipids...
February 21, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28235400/implementation-of-cardiovascular-disease-prevention-in-primary-health-care-enhancing-understanding-using-normalisation-process-theory
#14
Nerida Volker, Lauren T Williams, Rachel C Davey, Thomas Cochrane, Tanya Clancy
BACKGROUND: The reorientation of primary health care towards prevention is fundamental to addressing the rising burden of chronic disease. However, in Australia, cardiovascular disease prevention practice in primary health care is not generally consistent with existing guidelines. The Model for Prevention study was a whole-of-system cardiovascular disease prevention intervention, with one component being enhanced lifestyle modification support and addition of a health coaching service in the general practice setting...
February 24, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28229926/the-role-of-frailty-in-explaining-the-association-between-the-metabolic-syndrome-and-mortality-in-older-adults
#15
Emiel O Hoogendijk, Martijn Huisman, Adriana J van Ballegooijen
The association between the metabolic syndrome (MetS) and adverse outcomes in older adults may be explained by other health conditions. This study examined the role of frailty in explaining the association between MetS and mortality, independent of comorbidity. Data were used from 1247 men and women aged ≥65years of the Longitudinal Aging Study Amsterdam. MetS was assessed using the definition of the US National Cholesterol Education Program. Frailty was measured by the frailty phenotype. Mortality was monitored from 1995 until 2015...
February 14, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28228117/the-association-between-consecutive-days-heat-wave-and-cardiovascular-disease-mortality-in-beijing-china
#16
Qian Yin, Jinfeng Wang
BACKGROUND: Although many studies have examined the effects of heat waves on the excess mortality risk (ER) posed by cardiovascular disease (CVD), scant attention has been paid to the effects of various combinations of differing heat wave temperatures and durations. We investigated such effects in Beijing, a city of over 20 million residents. METHODS: A generalized additive model (GAM) was used to analyze the ER of consecutive days' exposure to extreme high temperatures...
February 23, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28227821/dual-modality-arterial-pulse-monitoring-system-for-continuous-blood-pressure-measurement
#17
Wen-Xuan Dai, Yuan-Ting Zhang, Jing Liu, Xiao-Rong Ding, Ni Zhao, Wen-Xuan Dai, Yuan-Ting Zhang, Jing Liu, Xiao-Rong Ding, Ni Zhao, Wen-Xuan Dai, Yuan-Ting Zhang, Xiao-Rong Ding, Ni Zhao, Jing Liu
Accurate and ambulatory measurement of blood pressure (BP) is essential for efficient diagnosis, management and prevention of cardiovascular diseases (CVDs). However, traditional cuff-based BP measurement methods provide only intermittent BP readings and can cause discomfort with the occlusive cuff. Although pulse transit time (PTT) method is promising for cuffless and continuous BP measurement, its pervasive use is restricted by its limited accuracy and requirement of placing sensors on multiple body sites...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227777/analysis-of-a-cardiovascular-model-for-the-study-of-the-autonomic-response-of-brugada-syndrome-patients
#18
Mireia Calvo, Virginie Le Rolle, Daniel Romero Perez, Nathalie Behar, Pedro Gomis, Philippe Mabo, Alfredo I Hernandez, Mireia Calvo, Virginie Le Rolle, Daniel Romero Perez, Nathalie Behar, Pedro Gomis, Philippe Mabo, Alfredo I Hernandez, Mireia Calvo, Daniel Romero Perez, Pedro Gomis, Philippe Mabo, Nathalie Behar, Alfredo I Hernandez, Virginie Le Rolle
This paper describes the integration of mathematical models of the cardiac electrical activity, the cardiovascular system and the baroreceptor reflex control of the autonomic nervous system, with a model representing a head-up tilt test. Sensitivity analyses are performed in order to determine those model parameters producing the greatest significant effects on heart rate and blood pressure. An optimization step is then applied to the most influential parameters in order to find the best model fit to real cardiac data obtained from a patient suffering from Brugada syndrome and a healthy subject, in supine and upright postures during a tilt test...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227484/design-of-peripheral-edema-measurement-device-for-home-use
#19
Stephanie M George, Brandon D Langley, Elizabeth M B Weaver, Sonya R Hardin, Jianchu Yao, Stephanie M George, Brandon D Langley, Elizabeth M B Weaver, Sonya R Hardin, Jianchu Yao, Brandon D Langley, Elizabeth M B Weaver, Jianchu Yao, Sonya R Hardin, Stephanie M George
Due to improvements in cardiovascular care, more patients are living longer but ultimately developing heart failure. It is important for patients with chronic conditions, like heart failure, to self-manage and monitor their symptoms. One symptoms that can be indicative of worsening heart failure is peripheral edema. Therefore, we present a concept for a HeartSMART system capable of edema measurement in the home with remote connection to and feedback from providers. The goal of the system is to provide a tool for heart failure patients to manage their disease...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227067/computational-estimation-of-the-severity-of-coronary-lesions-with-intravascular-ultrasound-images-a-pilot-study
#20
Panagiotis K Siogkas, Michail I Papafaklis, Bill D Gogas, Habib Samady, Lampros K Michalis, Dimitrios I Fotiadis, Panagiotis K Siogkas, Michail I Papafaklis, Bill D Gogas, Habib Samady, Lampros K Michalis, Dimitrios I Fotiadis, Bill D Gogas, Habib Samady, Michail I Papafaklis, Dimitrios I Fotiadis, Panagiotis K Siogkas, Lampros K Michalis
The fast and accurate hemodynamic functional assessment of the coronary vasculature is of utmost importance in clinical practice due to the fact that Cardiovascular Diseases have become the leading cause of death globally. In this work we propose a novel method that combines two of the most efficient methods of hemodynamic status assessment of coronary arteries, Intravascular UtraSound and virtual Functional Assessment Index, an index that correlates well to the measured Fractional Flow Reserve. One Left Anterior Descending segment was reconstructed both in a straight manner (using only IVUS images) as well as using the actual 3D geometry of the vessel (using IvUS images combined with the respective coronary angiographic images [2])...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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