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https://www.readbyqxmd.com/read/29029079/sialylation-of-extracellular-superoxide-dismutase-ec-sod-enhances-furin-mediated-cleavage-and-secretion
#1
Fumi Ota, Yasuhiko Kizuka, Miyako Nakano, Yoshiki Yamaguchi, Shinobu Kitazume, Tomomi Ookawara, Naoyuki Taniguchi
Extracellular superoxide dismutase (EC-SOD, SOD3) protects tissues against oxidative damage by detoxifying superoxide anions, particularly in the lungs and cardiovascular system. EC-SOD undergoes several posttranslational modifications including N-glycosylation and proteolytic cleavage. While the roles of proteolytic cleavage have been well studied, the structure and function of EC-SOD N-glycans are poorly understood. Here we analyzed glycan structures on native EC-SOD purified from human sera, and identified sialylated biantennary structures...
October 4, 2017: Glycobiology
https://www.readbyqxmd.com/read/29028556/buspirone-maintenance-does-not-alter-the-reinforcing-subjective-and-cardiovascular-effects-of-intranasal-methamphetamine
#2
Anna R Reynolds, Justin C Strickland, William W Stoops, Joshua A Lile, Craig R Rush
BACKGROUND: Medications development efforts for methamphetamine-use disorder have targeted central monoamines because these systems are directly involved in the effects of methamphetamine. Buspirone is a dopamine autoreceptor and D3 receptor antagonist and partial agonist at serotonin 1A receptors, making it a logical candidate medication for methamphetamine-use disorder. Buspirone effects on abuse-related behaviors of methamphetamine have been mixed in clinical and preclinical studies...
September 22, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29028353/activated-microglia-targeting-dendrimer-minocycline-conjugate-as-therapeutics-for-neuroinflammation
#3
Rishi Sharma, Soo-Young Kim, Anjali Sharma, Zhi Zhang, Siva Pramodh Kambhampati, Sujatha Kannan, Rangaramanujam M Kannan
Brain related disorders have outmatched cancer and cardiovascular diseases worldwide as the leading cause of morbidity and mortality. The lack of effective therapies and the relatively dry central nervous system (CNS) drug pipeline pose formidable challenge. Superior, targeted delivery of current clinically approved drugs may offer significant potential. Minocycline has shown promise for the treatment of neurological diseases owing to its ability to penetrate the blood brain barrier (BBB), and potency. Despite its potential in the clinic, and in preclinical models, the high doses needed to affect a positive therapeutic response has led to side effects...
October 13, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29027807/annals-express-biochemistry-of-the-menopause
#4
John W Honour
The life of a human female is characterised from teenage years by monthly menstruation which ceases (the menopause) typically between the age of 40 and 60 years. The potential for reproduction declines and ceases as the ovaries become depleted of follicles. A transition period in mid-life, for 2 to 10 years, when menstruation is less regular is called the peri-menopause. The menopause is associated with a significant decline in plasma concentrations of sex hormones, an increase in the concentrations of the gonadotrophins and changes in other hormones such as the inhibins...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29027531/-costal-cartilage-structural-and-functional-changes-in-children-with-a-funnel-or-keeled-chest
#5
A V Kurkov, A B Shekhter, V S Paukov
Congenital chest wall deformities (CCWDs) in children are severe diseases leading to cosmetic defects and diseases of the respiratory and cardiovascular systems. The most common of these deformities are funnel-shaped (pectus excavatum, FD) and keeled (pectus carinatum, KD) ones. The pathogenesis of CCWDs and the role of costal cartilage structural and functional changes in their pathogenesis have now been not well studied, which makes it difficult to elaborate pathogenetic approaches to correcting these diseases...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/29027470/next-generation-sequencing-applications-for-cardiovascular-disease
#6
Samira Kalayinia, Hamidreza Goodarzynejad, Majid Maleki, Nejat Mahdieh
The Human Genome Project (HGP), as the primary sequencing of the human genome, lasted more than one decade to be completed using the traditional Sanger's method. At present, next-generation sequencing (NGS) technology could provide the genome sequence data in hours. NGS has also decreased the expense of sequencing; therefore, nowadays it is possible to carry out both whole-genome (WGS) and whole-exome sequencing (WES) for the variations detection in patients with rare genetic diseases as well as complex disorders such as common cardiovascular diseases (CVDs)...
October 13, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/29026833/primary-prevention-of-cardiovascular-disease-in-older-adults-in-china
#7
REVIEW
Jian Yong, Dong Lin, Xue-Rui Tan
Over the past two decades, the percentage of Chinese who is 60 years or older has increased from 5.2% in 1995 to 10.5% in 2015. Approximately 16% of the population in China was 60 years old and above in 2015. Since 1990, cardiovascular disease (CVD) has been the leading cause of death in China. Cardiovascular medications of older adults are usually more complicated than younger age groups due to polypharmacy, the presence of comorbidities and more susceptible to treatment-related adverse outcomes. Therefore, effective primary prevention of CVD for older adults is important in sustaining the health of older adults and reducing the burden of the healthcare system...
September 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/29026772/lateral-medullary-syndrome-after-a-scorpion-sting
#8
Vineeth Varghese Thomas, Tina George, Ajay Kumar Mishra, Pavithra Mannam, I Ramya
Scorpion bites are a common problem in Southern parts of India. The sting of Mesobuthus tamulus belonging to the Buthidae family is known for being fatal. The toxidrome of scorpion sting is known for its effect on the cardiovascular system, and there have been rare reports of cerebrovascular accidents as well. We describe a case of lateral medullary syndrome secondary to scorpion sting. As per the knowledge of the authors, this is the first case report of the same.
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29025760/prediction-for-intravenous-immunoglobulin-resistance-by-using-weighted-genetic-risk-score-identified-from-genome-wide-association-study-in-kawasaki-disease
#9
Ho-Chang Kuo, Henry Sung-Ching Wong, Wei-Pin Chang, Ben-Kuen Chen, Mei-Shin Wu, Kuender D Yang, Kai-Sheng Hsieh, Yu-Wen Hsu, Shih-Feng Liu, Xiao Liu, Wei-Chiao Chang
BACKGROUND: Intravenous immunoglobulin (IVIG) is the treatment of choice in Kawasaki disease (KD). IVIG is used to prevent cardiovascular complications related to KD. However, a proportion of KD patients have persistent fever after IVIG treatment and are defined as IVIG resistant. METHODS AND RESULTS: To develop a risk scoring system based on genetic markers to predict IVIG responsiveness in KD patients, a total of 150 KD patients (126 IVIG responders and 24 IVIG nonresponders) were recruited for this study...
October 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29025749/late-onset-postcapillary-pulmonary-hypertension-in-patients-with-transposition-of-the-great-arteries-and-mustard-or-senning-baffles
#10
Marie-A Chaix, Annie Dore, Lise-Andrée Mercier, François-Pierre Mongeon, François Marcotte, Réda Ibrahim, Anita W Asgar, Azadeh Shohoudi, Fabien Labombarda, Blandine Mondésert, Nancy Poirier, Paul Khairy
BACKGROUND: There is a paucity of data regarding late-onset pulmonary hypertension (PH) in patients with transposition of the great arteries and atrial switch surgery. METHODS AND RESULTS: A retrospective cohort study was conducted on 140 adults with transposition of the great arteries and atrial switch surgery, age 37.3±7.8, 37.1% female, in order to assess the prevalence and characteristics of late-onset PH and explore associated factors. Patients were followed for a median of 32...
October 12, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29025425/prognostic-utility-of-differential-tissue-characterization-of-cardiac-neoplasm-and-thrombus-via-late-gadolinium-enhancement-cardiovascular-magnetic-resonance-among-patients-with-advanced-systemic-cancer
#11
Angel T Chan, Andrew J Plodkowski, Shawn C Pun, Yuliya Lakhman, Darragh F Halpenny, Jiwon Kim, Samantha R Goldburg, Mathew J Matasar, Chaya S Moskowitz, Dipti Gupta, Richard Steingart, Jonathan W Weinsaft
BACKGROUND: Late gadolinium enhancement (LGE-) cardiovascular magnetic resonance (CMR) is well-validated for cardiac mass (CMASS) tissue characterization to differentiate neoplasm (CNEO) from thrombus (CTHR): Prognostic implications of CMASS subtypes among systemic cancer patients are unknown. METHODS: CMASS + patients and controls (CMASS -) matched for cancer diagnosis and stage underwent a standardized CMR protocol, including LGE-CMR (IR-GRE) for tissue characterization and balanced steady state free precession cine-CMR (SSFP) for cardiac structure/function...
October 12, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29025323/cardiovascular-autonomic-responses-in-the-vcd-rat-model-of-menopause-effects-of-short-and-long-term-ovarian-failure
#12
Domitila A Huber, Darlan Bazilio, Flaviano Lorenzon, Sibele Sehnem, Lucas Pacheco, Janete A Anselmo-Franci, Fernanda B Lima
After menopause, hypertension elevates the risk of cardiac diseases, one of the major causes of women's morbidity. The gradual depletion of ovarian follicles in rats, induced by 4-vinylcyclohexene diepoxide (VCD), is a model for studying the physiology of menopause. 4-Vinylcyclohexene diepoxide treatment leads to early ovarian failure (OF) and a hormonal profile comparable to menopause in humans. We have hypothesized that OF can compromise the balance between sympathetic and parasympathetic tones of the cardiovascular system, shifting toward dominance of the former...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29024702/polycystic-ovarian-syndrome-pcos-long-term-metabolic-consequences
#13
Panagiotis Anagnostis, Basil C Tarlatzis, Robert P Kauffman
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women during their reproductive ages, associated with a plethora of cardiometabolic consequences, with obesity, insulin resistance and hyperandrogenemia playing a major role in the degree of such manifestations. These consequences include increased risk of glucose intolerance and diabetes mellitus (both type 2 and gestational), atherogenic dyslipidemia, systemic inflammation, non-alcoholic fatty liver disease, hypertension and coagulation disorders...
October 9, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29024031/first-genetic-analysis-of-atypical-phenotype-of-pseudoxanthoma-elasticum-with-ocular-manifestations-in-the-absence-of-characteristic-skin-lesions
#14
Takeshi Fukumoto, Akira Iwanaga, Atsushi Fukunaga, Mari Wataya-Kaneda, Yuta Koike, Chikako Nishigori, Atsushi Utani
Pseudoxanthoma elasticum (PXE) is an autosomal recessive disease, characterized by mineralization and degeneration of the elastic fibers in the skin, retina, and cardiovascular system.(1-4) PXE is caused by mutations in the ATP-binding cassette subfamily C member 6 (ABCC6) gene, but it remains unknown how these mutations lead to the clinical phenotype.(2-4) Although an association between mutations and phenotypes has been postulated, no definite correlation has been established.(5) Patients with PXE usually exhibit typical skin lesions that are frequently the first diagnostic signs...
October 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29023744/the-relationship-of-oral-health-with-general-health-and-ncds-a-brief-review
#15
Christof Dörfer, Christoph Benz, Jun Aida, Guillaume Campard
Oral health is closely related to systemic health. Periodontitis, a chronic inflammatory disease which is highly prevalent worldwide, interacts with a variety of noncommunicable diseases (NCDs). It is a risk factor in the complex pathogenesis of diabetes mellitus and cardiovascular disease and plays a role in the development of endocarditis and recurrent pneumonia in elderly people. However, the available data may be interpreted in different ways, and more and better-designed studies are still needed to answer relevant questions about the causal role of periodontitis in NCDs...
September 2017: International Dental Journal
https://www.readbyqxmd.com/read/29023675/european-marketing-authorizations-granted-based-on-a-single-pivotal-clinical-trial-the-rule-or-the-exception
#16
Anne Vinther Morant, Henrik Tang Vestergaard
A minimum of two positive, adequate and well-controlled clinical trials has historically been the gold standard for providing substantial evidence to support regulatory approval of a new medicine. Nevertheless, the present analysis of European marketing authorizations granted between 2012 and 2016 showed that 45% of new active substances were approved based on a single pivotal clinical trial. For therapeutic areas such as oncology and cardiovascular diseases, approvals based on a single pivotal trial are the rule rather than the exception, whereas new medicines within the nervous system area were generally supported by two or more pivotal trials...
October 11, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29023363/lps-induced-systemic-inflammation-does-not-alter-atherosclerotic-plaque-area-or-inflammation-in-apoe3-leiden-mice-in-the-early-phase-up-to-15-days
#17
Wessel W Fuijkschot, Martine C Morrison, Ilse P A Zethof, Paul A J Krijnen, Robert Kleemann, Hans W M Niessen, Yvo M Smulders
BACKGROUND AND AIMS: Observational studies show a peak incidence in cardiovascular events during and early after clinical conditions associated with substantial systemic inflammation, such as pneumonia. The acuteness of this increased risk suggests rapid plaque destabilization and associated intra-plaque inflammation. We evaluated whether LPS-evoked acute systemic inflammation would induce such detrimental vascular changes in murine aortas with manifest atherosclerotic lesions. METHODS AND RESULTS: ApoE3*Leiden mice were fed a high cholesterol diet for 20 weeks to establish atherosclerosis...
October 11, 2017: Shock
https://www.readbyqxmd.com/read/29023274/the-injury-and-illness-profile-of-male-and-female-participants-in-a-94-7-km-cycle-race-a-cross-sectional-study
#18
Mia Breedt, Dina C Janse van Rensburg, Lizelle Fletcher, Catharina C Grant, Martin P Schwellnus
OBJECTIVE: To describe the incidence and patterns of injury and illness of male and female participants during a 94.7 km distance cycling event. DESIGN: Descriptive study. SETTING: Momentum 94.7 Cycle Challenge 2014. PARTICIPANTS: All 23 055 race starters (males = 17 520, females = 5236, not specified = 299). MAIN OUTCOME MEASURES: The incidence and type of all medical complaints and difference between sexes...
October 11, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29022680/patients-risk-of-causing-traffic-violations-and-traffic-accidents-while-driving
#19
Nevenka Šestan, Metoda Dodič Fikfak, Zvone Balantič
OBJECTIVES: This study examines whether drivers suffering from epilepsy, chronic alcoholism and/or hazardous drinking, psychoactive substance abuse, other diseases of the nervous system, mental and behavioural disorders, cardiovascular diseases, severe diabetes, and severe eye diseases are at a greater risk of causing traffic accidents and traffic violations than drivers that cause accidents and violations without these diagnoses. METHODS: A case control study was carried out...
September 2017: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29022570/arterial-stiffness-as-a-risk-factor-for-clinical-hypertension
#20
REVIEW
Michel E Safar
In patients with uncomplicated essential hypertension, cardiac output remains within normal ranges and intravascular volume is normal or low, assuming the presence of a sufficient Windkessel effect and usual resistance and compliance calculations. However, mean circulatory pressure is elevated in these patients. In addition, vascular resistance is augmented, and most importantly, the viscoelasticity of the cardiovascular system is substantially impaired. Such considerations are essential to understanding the mechanisms behind carotid-femoral arterial stiffness, a major risk factor in individuals with hypertension...
October 12, 2017: Nature Reviews. Cardiology
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