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https://www.readbyqxmd.com/read/29232725/value-of-contrast-enhanced-ultrasound-quantification-criteria-for-identifying-patients-not-responding-to-bevacizumab-based-therapy-for-colorectal-liver-metastases
#1
François Tranquart, Paul-Armand Dujardin, Olivier Bouché, Claude Marcus, Christophe Borg, Philippe Manzoni, Jean-Yves Douillard, Catherine Labbe-Devilliers, Eric Terrebonne, Denis Smith, Herve Trillaud, Olivier Capitain, Cristophe Aubé, Jean-Philippe Spano, Olivier Lucidarme, Aurélie Ferru, Jean-Pierre Tasu, Sylvain Manfredi, Aurore Bleuzen, Julie Léger, Thierry Lecomte
Purpose To evaluate changes in tumor vascularization parameters based on contrast-enhanced ultrasound (CEUS) quantification criteria of at least one visible liver metastasis as an early predictor of non-response to chemotherapy, including bevacizumab for colorectal cancer (CRC) liver metastases. Materials and Methods This multicenter prospective study included patients who received first-line bevacizumab-based chemotherapy. Tumor enhancement measured using CEUS within one liver metastasis and in relation to the surrounding healthy liver was quantified within 8 days before the first infusion of bevacizumab (E0), 24 hours after the end of the first infusion of bevacizumab (E1), in the 24 hours before the 2nd and 3 rd infusion of bevacizumab on day 15 (E2) and day 30 (E3), respectively, and after 2 months of treatment (E4)...
December 12, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29232724/inter-rater-reliability-of-air-saline-hycosy-hyfosy-and-hyfosy-combined-with-power-doppler-for-screening-tubal-patency
#2
Inga Ludwin, Artur Ludwin, Carolina O Nastri, Marcela A Coelho Neto, Jan Kottner, Wellington P Martins
Purpose To estimate the inter-observer reliability and agreement of offline analyses of three different ultrasound techniques for assessing tubal patency. Methods 100 tubes (n = 100) in 50 women were evaluated for tubal patency between November 2013 and July 2015 using ultrasound as index tests and laparoscopy as the reference standard. Three different ultrasound techniques were applied: two-dimensional grayscale ultrasound using air + saline as the contrast media (2D-HyCoSy); two- and three-dimensional grayscale ultrasound using foam as the contrast media (2 D/3D-HyFoSy); and the same technique but adding bi-directional power Doppler (2 D/3D-Doppler-HyFoSy)...
December 12, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29232715/profound-loss-of-neprilysin-accompanied-by-decreased-levels-of-neuropeptides-and-increased-crp-in-ulcerative-colitis
#3
Zeynep Gök Sargın, Nuray Erin, Gokhan Tazegul, Gülsüm Özlem Elpek, Bülent Yıldırım
Neprilysin (NEP, CD10) acts to limit excessive inflammation partly by hydrolyzing neuropeptides. Although deletion of NEP exacerbates intestinal inflammation in animal models, its role in ulcerative colitis (UC) is not well explored. Herein, we aimed to demonstrate changes in NEP and associated neuropeptides at the same time in colonic tissue. 72 patients with UC and 27 control patients were included. Patients' demographic data and laboratory findings, five biopsy samples from active colitis sites and five samples from uninvolved mucosa were collected...
2017: PloS One
https://www.readbyqxmd.com/read/29232701/differential-impact-of-white-matter-hyperintensities-on-long-term-outcomes-in-ischemic-stroke-patients-with-large-artery-atherosclerosis
#4
Minyoul Baik, Kyoungsub Kim, Joonsang Yoo, Hyeon Chang Kim, Seong Ho Jeong, Ki Hoon Kim, Hyung Jong Park, Young Dae Kim, Ji Hoe Heo, Hyo Suk Nam
BACKGROUND: The presence of white matter hyperintensity (WMH) is related to poor long-term outcomes in stroke patients. However, the long-term outcome is unknown in patients with both large artery atherosclerosis (LAA) and WMH. METHODS: We investigated the impact of WMH on long-term outcome in patients with LAA. Consecutive patients in a prospective stroke registry were included. Patients were followed for a median of 7.7 years (interquartile range, 5.6-9.7). The degree of WMH was assessed by Fazekas grade on fluid-attenuated inversion recovery images...
2017: PloS One
https://www.readbyqxmd.com/read/29232679/clinicopathological-and-prognostic-features-of-surgical-management-in-duodenal-gastrointestinal-stromal-tumors
#5
Hong Peng Shi, Min Lu Huang, Zhen Qiang Wang, Ya Nan Zheng, Zheng Lun Zhu, Birendra Kumar Sah, Wen Tao Liu, Min Yan, Zheng Gang Zhu, Chen Li
BACKGROUND AND OBJECTIVES: The rarity of duodenal gastrointestinal stromal tumors (DGIST) led to only limited data being available on their management and prognosis. We retrospectively analyzed the clinicopathological features, surgical treatments, adjuvant therapy, and prognosis of DGIST. METHODS: Sixty-one patients were identified at diagnosis of primary DGIST from February 2005 to December 2015. One hundred twenty six patients with small intestinal gastrointestinal stromal tutors (GIST) were selected as control groups...
December 12, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/29232669/implication-of-haemodiafiltration-flow-rate-on-amikacin-pharmacokinetic-parameters-in-critically-ill-patients
#6
Jesús Ruiz-Ramos, Esther Villarreal, Mónica Gordon, María Martin-Cerezula, Maria Jesús Broch, María Remedios Marqués, Jose Luis Poveda, Álvaro Castellanos-Ortega, Paula Ramírez
BACKGROUND: To analyse the effect of haemodiafiltration (CVVHDF) flow rate on amikacin pharmacokinetics and blood concentrations. METHODS: Prospective observational study. Patients receiving CVVHDF and amikacin treatment were included. Pharmacokinetic parameters were calculated using Bayesian analysis. Spearman correlation test was used in order to assess the influence of CVVHDF flux on amikacin minimum concentration (Cmin) and plasma clearance. RESULTS: Thirty patients undergoing CVVHDF procedures were included...
December 12, 2017: Blood Purification
https://www.readbyqxmd.com/read/29232666/validation-of-the-hebrew-version-of-the-eating-assessment-tool-10-h-eat-10
#7
Sara Abu-Ghanem, Melissa Schechter, Hanna Flesh-Eyni, Liat Litwin, Esti Makai, Yael Oestreicher-Kedem, Moshe Yehuda
BACKGROUND AND OBJECTIVES: Dysphagia is a common disability with different etiologies. In order to measure dysphagia symptom severity and effects on quality of life, the Eating Assessment Tool (EAT-10) was developed and validated in the English language. We aimed to develop a Hebrew version of the EAT-10 and to evaluate its internal consistency, test-retest reliability, and validity in Hebrew-speaking adults with dysphagia. SUBJECTS AND METHODS: The Hebrew EAT-10 (H-EAT-10) questionnaire was completed by 132 patients: 56 patients with dysphagia and 76 controls...
December 12, 2017: Folia Phoniatrica et Logopaedica
https://www.readbyqxmd.com/read/29232648/template-directed-fabrication-of-mil-101-cr-mesoporous-silica-composite-layer-packed-structure-and-enhanced-performance-for-co2-capture
#8
Chong Chen, Nengjie Feng, Qirui Guo, Zhong Li, Xue Li, Jing Ding, Lei Wang, Hui Wan, Guofeng Guan
A novel hybrid material constituted of MIL-101(Cr) and mesoporous silica was successfully assembled through an in-situ hydrothermal method. The MCM-41 with well-ordered mesopores acted as the structure-directing agent, which regulated the growth of MIL-101(Cr) crystals along a certain direction and restricted the expansion of framework. Meanwhile, the hydroxyl groups existed in MCM-41 preferentially coordinated with the Cr3+ centers in MOF, followed by the layer-packed arrangement of MIL-101(Cr) nanocrystals on the surface of matrix...
December 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29232646/determination-of-uv-filters-in-human-breast-milk-using-turbulent-flow-chromatography-and-babies-daily-intake-estimation
#9
Daniel Molins-Delgado, María Del Mar Olmo-Campos, Gemma Valeta-Juan, Vanessa Pleguezuelos-Hernández, Damià Barceló, M Silvia Díaz-Cruz
UV filters (UV-Fs) are a group of hormonally active chemical compounds used to protect against the deleterious effects of UVA and UVB solar radiation, which are currently present in most consumer goods (personal care products, plastics, fabrics, paints, etc). Last years the concern about these emerging contaminants has been on the rise, and increasing efforts are being taken in order to properly asses the hazard that the exposure to these compounds in the early stages of life may pose. In this study, a new method for the analysis of 11 UV-Fs residues in human breast milk samples has been developed...
December 9, 2017: Environmental Research
https://www.readbyqxmd.com/read/29232622/cognitive-mechanisms-underlying-third-graders-arithmetic-skills-expanding-the-pathways-to-mathematics-model
#10
Ulf Träff, Linda Olsson, Kenny Skagerlund, Rickard Östergren
A modified pathways to mathematics model was used to examine the cognitive mechanisms underlying arithmetic skills in third graders. A total of 269 children were assessed on tasks tapping the four pathways and arithmetic skills. A path analysis showed that symbolic number processing was directly supported by the linguistic and approximate quantitative pathways. The direct contribution from the four pathways to arithmetic proficiency varied; the linguistic pathway supported single-digit arithmetic and word problem solving, whereas the approximate quantitative pathway supported only multi-digit calculation...
December 9, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29232610/electrospun-polydimethylsiloxane-polyacrylonitrile-titanium-dioxide-nanofibers-as-a-new-coating-for-determination-of-alpha-linolenic-acid-in-milk-by-direct-immersion-solid-phase-nanoextraction
#11
Sahar Sadeghi, Afsaneh Mollahosseini
In this study, polydimethylsiloxane/polyacrylonitrile/titanium dioxide (PDMS/PAN/TiO2) nanofibers were synthesized via electrospinning method to extract and quantify alpha-linolenic acid (ALA, C18:3), as a model analyte, in milk by direct immersion-solid phase nanoextraction (DI-SPNE) with gas chromatography-flame ionization detector (GC-FID). The affecting factors on the electrospinning process such as, PDMS concentration, amount of TiO2 nanoparticles (NPs), voltage, and electrospinning distance were optimized using Taguchi's orthogonal design...
December 9, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29232572/facile-biological-synthetic-strategy-to-morphologically-aligned-ceo2-zro2-core-nanoparticles-using-justicia-adhatoda-extract-and-ionic-liquid-enhancement-of-its-bio-medical-properties
#12
Nithya Pandiyan, Balaji Murugesan, Jegatheeswaran Sonamuthu, Selvam Samayanan, Sundrarajan Mahalingam
In this study, a typical green synthesis route has approached for CeO2/ZrO2 core metal oxide nanoparticles using ionic liquid mediated Justicia adhatoda extract. This synthesis method is carried out at simple room temperature condition to obtain the core metal oxide nanoparticles. XRD, SEM and TEM studies employed to study the crystalline and surface morphological properties under nucleation, growth, and aggregation processes. CeO2/ZrO2 core metal oxides display agglomerated nano stick-like structure with 20-45nm size...
November 28, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29232571/investigating-the-excited-state-optical-properties-and-origin-of-large-stokes-shift-in-benz-c-d-indole-n-heteroarene-bf2-dyes-with-ab-initio-tools
#13
Yogesh Gawale, Nagaiyan Sekar
Density Functional Theory and Time Dependent Density Functional Theory computations reveal experimental trends accurately and provide an insight into the origin of red shifted optical spectra, large Stokes shift, nonlinear optical responses and quantitative description of the singlet-triplet energy gap of recently synthesized highly fluorescent membrane permeable benz[c,d]indole N-heteroarene BF2 rigidified BBN and BBC dyes. Our results benchmark the importance of the DFT functionals and polarization functions using the accurate basis set for the calculations of excitation energies, band gaps, dipole moment, non-linear optical properties and geometrical parameters...
December 7, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29232563/immunologic-burden-links-periodontitis-to-acute-coronary-syndrome
#14
John M Liljestrand, Susanna Paju, Milla Pietiäinen, Kåre Buhlin, G Rutger Persson, Markku S Nieminen, Juha Sinisalo, Päivi Mäntylä, Pirkko J Pussinen
BACKGROUND AND AIMS: Periodontitis, a common polymicrobial inflammatory disease in the tooth supporting tissues, is a risk factor for coronary artery disease. One of the proposed underlying mechanisms is the systemic immune response to periodontal infection. We studied how serum antibodies against seven periodontal pathogens and their subgingival levels associate with each other, periodontitis, and coronary artery disease. METHODS: The Parogene cohort included 505 Finnish patients (mean age 63 y) who underwent coronary angiography, and clinical and radiographic oral examinations...
December 6, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29232519/using-density-based-indexes-and-wavefunction-methods-for-the-description-of-excited-states-excited-state-proton-transfer-reactions-as-test-case
#15
Juan Sanz García, Federica Maschietto, Marco Campetella, Ilaria Ciofini
To provide tools to interpret photochemical reactions, in this paper we demonstrate how a recently developed density-based index (DCT), up to now used in conjunction with Time Dependent Density Functional Theory methods, can be extended to multi-configurational methods. This index can guide chemists in the interpretation of photochemical reactions providing a measure of the spatial extent of a photo-induced charge transfer and, more generally, of charge transfer phenomena. This qualitative and quantitative description can be particularly relevant in the case of multi-configurational calculations providing a simple tool for the interpretation of their complex outputs...
December 12, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29232518/theoretical-study-on-the-photoinduced-electron-transfer-mechanisms-of-different-peroxynitrite-probes
#16
Li Li, Minghui Zan, Xingwang Qie, Juan Yue, Peng Miao, Mingfeng Ge, Zhimin Chang, Zheng Wang, Fuquan Bai, Hong-Xing Zhang, James Kit Ferri, Wen-Fei Dong
The development of probes for rapid and selective detection of peroxynitrite in vivo is of great importance in biological science. We investigate different photoinduced electron transfer (PET) processes of two generations of peroxynitrite probes. Each has fluorescein and phenol moieties; one is conjugated by an ether linkage while the other is conjugated via an amine linkage. Using theoretical calculations, we demonstrated that the PET in the probe with an ether linkage occurs from the benzoic acid to the xanthene moiety...
December 12, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29232517/formation-of-c9h2-and-c10h2-from-reactions-c3h-c6h2-and-c4h-c6h2
#17
Yi-Lun Sun, Wen-Jian Huang, Shih-Huang Lee
The reactions of C3H and C4H radicals with C6H2 were investigated for the first time. Reactants C3H, C4H, and C6H2 were synthesized in two beams of C2H2 diluted with helium by pulsed high-voltage discharge. We measured translational-energy distributions, angular distributions, and photoionization-efficiency spectra of C9H2 and C10H2 produced from the title reactions in a crossed molecular-beam apparatus using synchrotron vacuum-ultraviolet photoionization. The C3H (C4H) + C6H2 reaction releases 42% (33%) of available energy into the translational degrees of freedom of product C9H2 (C10H2) + H and scatters products into a nearly isotropic angular distribution...
December 12, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29232511/quadratic-response-properties-from-tddft-trials-and-tribulations
#18
Shane M Parker, Dmitrij Rappoport, Filipp Furche
We report on the efficient Turbomole implementation of quadratic response properties within the time-dependent density functional theory (TDDFT) context that includes the static and dynamic dipole hyperpolarizability, ground-to-excited-state two-photon absorption amplitudes (through a single residue) and state-to-state one-photon absorption amplitudes (through a double residue). Our implementation makes full use of arbitrary (including non-Abelian) point-group symmetry as well as permutational symmetry and enables the calculation of nonlinear properties with hybrid density functionals for molecules with hundreds of atoms and thousands of basis functions at a cost that is a fixed multiple of the cost of the corresponding linear properties...
December 12, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29232503/calculation-of-magnetic-shielding-constants-with-meta-gga-functionals-employing-the-multipole-accelerated-resolution-of-the-identity-implementation-and-assessment-of-accuracy-and-efficiency
#19
Kevin Reiter, Fabian Mack, Florian Weigend
We present a highly efficient implementation for density functional calculations of chemical shielding constants. It employs the multipole-accelerated resolution of the identity for the calculation of the Coulomb part, which complements the usage of low order scaling routines for the evaluation of the exchange-correlation part and the Hartree-Fock exchange part. Introduced errors for shifts of chemical shielding constants of H, C, F and P are evaluated for respective test sets of molecules and are related to the accuracy of shifts obtained with hybrid and non-hybrid functionals of the generalized gradient approximation type as well as for meta-GGA functionals themselves, also considering solvation effects...
December 12, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29232410/early-variations-of-laboratory-parameters-predicting-shunt-dependent-hydrocephalus-after-subarachnoid-hemorrhage
#20
Min Kyun Na, Yu Deok Won, Choong Hyun Kim, Jae Min Kim, Jin Hwan Cheong, Je Il Ryu, Myung-Hoon Han
BACKGROUND AND PURPOSE: Hydrocephalus is a frequent complication following subarachnoid hemorrhage. Few studies investigated the association between laboratory parameters and shunt-dependent hydrocephalus. This study aimed to investigate the variations of laboratory parameters after subarachnoid hemorrhage. We also attempted to identify predictive laboratory parameters for shunt-dependent hydrocephalus. METHODS: Multiple imputation was performed to fill the missing laboratory data using Bayesian methods in SPSS...
2017: PloS One
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