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oral squamous cell cancer sentinel

Kouki Miura, Hitoshi Hirakawa, Hirokazu Uemura, Seiichi Yoshimoto, Akihiro Shiotani, Masashi Sugasawa, Akihiro Homma, Junkichi Yokoyama, Kiyoaki Tsukahara, Tomokazu Yoshizaki, Yasushi Yatabe, Keitaro Matsuo, Yasuo Ohkura, Shigeru Kosuda, Yasuhisa Hasegawa
OBJECTIVE: A recent study identified a survival benefit with prophylactic neck dissection (ND) at the time of primary surgery as compared with watchful waiting followed by therapeutic neck dissection for nodal relapse, in patients with cN0 oral squamous cell carcinoma (OSCC). Alternative management of cN0 neck cancer is recommended to minimize the adverse effects of ND, indicating the need for sentinel node biopsy (SNB) and limited neck dissection. We conducted a multicenter Phase II study to examine the feasibility of SNB for clinically N0 OSCC...
August 2, 2016: Auris, Nasus, Larynx
Akimitsu Hiraki, Daiki Fukuma, Masashi Nagata, Shinya Shiraishi, Kenta Kawahara, Yuichiro Matsuoka, Yoshihiro Nakagawa, Ryoji Yoshida, Takuya Tanaka, Yoshihiro Yoshitake, Masanori Shinohara, Yasuyuki Yamashita, Hideki Nakayama
It has recently been established that sentinel node biopsy (SNB) is an applicable and feasible procedure for the prediction of neck lymph node status in patients with early oral squamous cell carcinoma (OSCC) who are clinically negative for neck metastasis (cN0). The aim of this study was to retrospectively compare excision followed by watchful waiting with excision and SNB, in order to determine the effectiveness of SNB. A total of 125 patients with cN0 early OSCC were divided into two groups, namely the excision alone (n=78) and excision with SNB (n=47) groups...
July 2016: Molecular and Clinical Oncology
Girolamo Tartaglione, Sandro J Stoeckli, Remco de Bree, Clare Schilling, Geke B Flach, Vivi Bakholdt, Jens Ahm Sorensen, Anders Bilde, Christian von Buchwald, Georges Lawson, Didier Dequanter, Pedro M Villarreal, Manuel Florentino Fresno Forcelledo, Julio Alvarez Amezaga, Augusto Moreira, Tito Poli, Cesare Grandi, Maurizio Giovanni Vigili, Michael O'Doherty, Davide Donner, Elisabeth Bloemena, Siavash Rahimi, Benjamin Gurney, Stephan K Haerle, Martina A Broglie, Gerhard F Huber, Annelise L Krogdah, Lars R Sebbesen, Edward Odell, Luis Manuel Junquera Gutierrez, Luis Barbier, Joseba Santamaria-Zuazua, Manuel Jacome, Marie-Cecile Nollevaux, Emma Bragantini, Philippe Lothaire, Enrico M Silini, Enrico Sesenna, Giles Dolivet, Romina Mastronicola, Agnes Leroux, Isabel Sassoon, Philip Sloan, Patrick M Colletti, Domenico Rubello, Mark McGurk
PURPOSE: Nuclear imaging plays a crucial role in lymphatic mapping of oral cancer. This evaluation represents a subanalysis of the original multicenter SENT trial data set, involving 434 patients with T1-T2, N0, and M0 oral squamous cell carcinoma. The impact of acquisition techniques, tracer injection timing relative to surgery, and causes of false-negative rate were assessed. METHODS: Three to 24 hours before surgery, all patients received a dose of Tc-nanocolloid (10-175 MBq), followed by lymphoscintigraphy...
July 2016: Clinical Nuclear Medicine
Ryota Oka, Koh-Ichi Nakashiro, Hiroyuki Goda, Kazuki Iwamoto, Norihiko Tokuzen, Hiroyuki Hamakawa
Cervical lymph node metastasis is an important prognostic factor in oral squamous cell carcinoma (OSCC), but its accurate assessment after sentinel node biopsy or neck dissection is often limited to the histopathological examination of only one or two sections. Previous our study showed the usefulness of the reverse transcription loop-mediated isothermal amplification (RT-LAMP) targeting keratin 19 (KRT19) mRNA for the genetic detection of lymph node metastasis, but the sensitivity was insufficient. Here, we have attempted to identify novel molecular markers for OSCC cells in lymph nodes...
January 26, 2016: Oncotarget
Clare Schilling, Sandro J Stoeckli, Stephan K Haerle, Martina A Broglie, Gerhard F Huber, Jens Ahm Sorensen, Vivi Bakholdt, Annelise Krogdahl, Christian von Buchwald, Anders Bilde, Lars R Sebbesen, Edward Odell, Benjamin Gurney, Michael O'Doherty, Remco de Bree, Elisabeth Bloemena, Geke B Flach, Pedro M Villarreal, Manuel Florentino Fresno Forcelledo, Luis Manuel Junquera Gutiérrez, Julio Alvarez Amézaga, Luis Barbier, Joseba Santamaría-Zuazua, Augusto Moreira, Manuel Jacome, Maurizio Giovanni Vigili, Siavash Rahimi, Girolamo Tartaglione, Georges Lawson, Marie-Cecile Nollevaux, Cesare Grandi, Davide Donner, Emma Bragantini, Didier Dequanter, Philippe Lothaire, Tito Poli, Enrico M Silini, Erinco Sesenna, Giles Dolivet, Romina Mastronicola, Agnes Leroux, Isabel Sassoon, Philip Sloan, Mark McGurk
PURPOSE: Optimum management of the N0 neck is unresolved in oral cancer. Sentinel node biopsy (SNB) can reliably detect microscopic lymph node metastasis. The object of this study was to establish whether the technique was both reliable in staging the N0 neck and a safe oncological procedure in patients with early-stage oral squamous cell carcinoma. METHODS: An European Organisation for Research and Treatment of Cancer-approved prospective, observational study commenced in 2005...
December 2015: European Journal of Cancer
Anders Christensen, Karina Juhl, Birgitte Charabi, Jann Mortensen, Katalin Kiss, Andreas Kjær, Christian von Buchwald
BACKGROUND: Sentinel node biopsy (SNB) is an established method in oral squamous cell carcinoma (OSCC) for staging the cN0 neck and to select patients who will benefit from a neck dissection. Near-infrared fluorescence (NIRF) imaging has the potential to improve the SNB procedure by facilitating intraoperative visual identification of the sentinel lymph node (SN). The purpose of this study was to evaluate the feasibility of fluorescence tracer imaging for SN detection in conjunction with conventional radio-guided technique...
February 2016: Annals of Surgical Oncology
R Murase, H Tanaka, T Hamakawa, H Goda, T Tano, A Ishikawa, S Hino, T Sumida, K Nakashiro, H Hamakawa
Oral squamous cell carcinoma (OSCC) frequently metastasizes to cervical lymph nodes, which is the most known prognostic factor. Screening methods to identify sentinel lymph nodes (SLNs) are therefore of great interest for the management of potential neck metastasis. The purpose of this study was to evaluate the clinical benefit of double SLN mapping with indocyanine green (ICG) and 99m-technetium-tin colloid ((99m)Tc-tin colloid) for sentinel node navigation surgery (SNNS). Between 2007 and 2010, 16 patients diagnosed with OSCC were investigated by SLN biopsy using the double mapping method...
October 2015: International Journal of Oral and Maxillofacial Surgery
T M Govers, W H Schreuder, W M C Klop, J P C Grutters, M M Rovers, M A W Merkx, R P Takes
OBJECTIVES: To examine health utilities in patients with cT1-2 oral cavity squamous cell carcinoma following different diagnostic and treatment modalities for the neck and to investigate the relation between shoulder morbidity and health utility. DESIGN: Cross-sectional survey. SETTING: Two Dutch hospitals. PARTICIPANTS: Four subgroups of patients with oral cavity cancer who underwent watchful waiting, sentinel lymph node biopsy, elective supraomohyoid neck dissection or therapeutic modified radical neck dissection...
June 2016: Clinical Otolaryngology
Nicklas Juel Pedersen, David Hebbelstrup Jensen, Nora Hedbäck, Martin Frendø, Katalin Kiss, Giedrius Lelkaitis, Jann Mortensen, Anders Christensen, Lena Specht, Christian von Buchwald
BACKGROUND: The purpose of this study was to examine the diagnostic accuracy of detecting lymph node metastases and to identify predictive and prognostic clinicopathological factors in patients with oral squamous cell carcinoma (OSCC) undergoing sentinel lymph node biopsy (SLNB). METHODS: All patients diagnosed with cT1 to T2N0 OSCC who underwent a diagnostic SLNB between 2007 and 2013 were included. RESULTS: We identified 253 patients, of whom 27% had a positive sentinel lymph node (SLB)...
April 2016: Head & Neck
Devaki Shilpa Surasi, Janis O'Malley, Pradeep Bhambhvani
Preoperative lymphatic mapping in conjunction with intraoperative γ-probe detection is widely used for sentinel node localization in melanoma, breast cancer, and other malignancies. (99m)Tc-radiocolloids have been the standard radiotracers used for sentinel node mapping. (99m)Tc-tilmanocept is a receptor-binding molecular imaging agent approved by the U.S. Food and Drug Administration for lymphatic mapping and lymph node localization in breast cancer, melanoma, clinically node-negative squamous cell carcinoma of the oral cavity, and other solid tumors...
June 2015: Journal of Nuclear Medicine Technology
Roger W Farmer, Linda McCall, Francisco J Civantos, Jeffrey N Myers, Wendell G Yarbrough, Barbara Murphy, Miriam O'Leary, Robert Zitsch, Barry A Siegel
OBJECTIVE: The purpose of our study was to correlate sentinel lymph nodes (SLN) found on planar lymphoscintigraphy (LS) to SLN found with gamma probe-directed sentinel lymph node biopsy (SLNB) for T1/T2 N0 oral cavity cancer. STUDY DESIGN: Prospective cooperative group trial. SETTING: Academic medical centers. SUBJECTS AND METHODS: One hundred forty adults with untreated T1/T2 N0 squamous cell carcinoma (SCC) of the oral cavity underwent planar LS, resection, SLNB, and neck dissection...
April 2015: Otolaryngology—Head and Neck Surgery
Rajaraman Ramamurthy, Rajkumar Kottayasamy Seenivasagam, Subbiah Shanmugam, Kathirvelkumaran Palanivelu
Sentinel Lymph Node (SLN) biopsy using a combination of radioisotopes and blue dyes have a good accuracy rate in predicting subclinical neck nodal metastases in head and neck cancers. However, the limited availability of lymphoscintigraphy facilities in India requires exploration of alternative methods of SLN detection. We evaluated the feasibility of using methylene blue dye alone in detecting SLN in cN0 early oral cancers. 32 patients with cN0 early (T1, T2) oral squamous cell cancers underwent SLN biopsy using peri tumoural methylene blue dye injection...
September 2014: Indian Journal of Surgical Oncology
Geoffrey P Luke, Jeffrey N Myers, Stanislav Y Emelianov, Konstantin V Sokolov
Metastases rather than primary tumors are responsible for killing most patients with cancer. Cancer cells often invade regional lymph nodes (LN) before colonizing other parts of the body. However, due to the low sensitivity and specificity of current imaging methods to detect localized nodal spread, an invasive surgical procedure--sentinel LN biopsy--is generally used to identify metastatic cancer cells. Here, we introduce a new approach for more sensitive in vivo detection of LN micrometastases, based on the use of ultrasound-guided spectroscopic photoacoustic (sPA) imaging of molecularly activated plasmonic nanosensors (MAPS)...
October 1, 2014: Cancer Research
Christina Bluemel, Ken Herrmann, Alexander Kübler, Andreas K Buck, Eva Geissinger, Vanessa Wild, Stefan Hartmann, Constantin Lapa, Christian Linz, Urs Müller-Richter
PURPOSE: The aim of this study was to prospectively evaluate the feasibility and potential advantages of freehand single-photon emission computed tomography (fhSPECT) compared with conventional intraoperative localization techniques for sentinel lymph node biopsy (SLNB) in oral cancer. METHODS: Between November 2012 and February 2014, 23 consecutive patients with clinical T1/T2 oral squamous cell carcinoma and a cN0 neck were recruited. All patients underwent SLNB followed by elective neck dissection (END)...
December 2014: European Journal of Nuclear Medicine and Molecular Imaging
J Philip, R James
Intraoral maxillary squamous cell carcinoma (IOMSCC) tumours are comparatively rare compared to those occurring at other oral sites. This has resulted in limited studies regarding their pattern of local and regional behaviour. In a review of the IOMSCC cohort (N=39) at the study institution, IOMSCC was found to demonstrate a pattern of levels 1-3 nodal disease in the N+ neck at presentation (33.3%), with a total metastatic rate of 46.1%, which is similar to that for other intraoral sites. IOMSCC demonstrated metastatic potential to the contralateral neck, with 20% of patients progressing to present with disease...
October 2014: International Journal of Oral and Maxillofacial Surgery
S Arya, P Rane, A Deshmukh
Squamous cell carcinoma (SCC) is the commonest malignancy in the oral cavity. The oral cavity has several subsites. Knowledge of the patterns of disease spread at each subsite with the impact on treatment and prognosis provides a deeper understanding of the role of imaging. Information from imaging helps accurate staging, assess resectability, and plan multimodality treatment. Mandibular erosion, posterior soft tissue extent, and perineural spread influence treatment and prognosis in gingival, buccal, and retromolar trigone (RMT) cancers...
September 2014: Clinical Radiology
Pankaj Chaturvedi, Sourav Datta, Supreeta Arya, Venkatesh Rangarajan, Shubhada V Kane, Deepa Nair, Sudhir Nair, Devendra A Chaukar, Prathamesh S Pai, Gouri Pantvaidya, Anuja D Deshmukh, Archi Agrawal, Anil K D'Cruz
BACKGROUND: The purpose of this study was to compare sentinel node biopsy (SNB) and ultrasound-guided fine-needle aspiration cytology (FNAC) for preoperative evaluation of the N0 neck in T1 to T2 oral cavity squamous cell carcinoma (SCC). METHODS: Fifty-one consecutive patients with T1 to T2 N0 oral cavity SCC were included in this study. Preoperative ultrasound was performed in all patients. Ultrasound-guided FNAC was performed in patients in whom the ultrasound result was reported as indeterminate or positive...
October 2015: Head & Neck
Seraina Denoth, Martina A Broglie, Stephan K Haerle, Gerhard F Huber, Sarah R Haile, Alex Soltermann, Wolfram Jochum, Sandro J Stoeckli
BACKGROUND: Sentinel lymph node biopsy is a reliable technique for accurate determination of the cervical lymph node status in patients with early oral and oropharyngeal cancer but analyses on the distribution pattern of metastatic spread within sentinel lymph nodes are lacking. METHODS: The localizations of carcinoma deposits were analyzed with a virtual microscope by creating digital images from the microscopic glass slides. RESULTS: Metastatic deposits were not randomly distributed within sentinel lymph nodes but were predominant in the central planes closer to the lymphatic inlet...
October 2015: Head & Neck
Ken Omura
The primary treatment modality of oral cancer is generally determined according to the stage of the disease, with surgical treatment remaining the mainstay of multimodal treatment. When selecting the treatment, many factors are taken into consideration, and the treatment should be tailored individually to the patient's needs and consider the quality of life as well as the survival of the patient. Early-stage disease is primarily managed with surgery or brachytherapy without functional morbidity, whereas for advanced-stage disease multidisciplinary treatment is recommended, not only for enhanced survival but also for improved quality of life...
2014: International Journal of Clinical Oncology
Inne J Den Toom, Derrek A Heuveling, Géke B Flach, Stijn van Weert, K Hakki Karagozoglu, Annelies van Schie, Elisabeth Bloemena, C René Leemans, Remco de Bree
BACKGROUND: Sentinel node biopsy (SNB) in head and neck cancer is recently introduced as the staging technique of oral squamous cell carcinoma. We report the results of SNB in patients diagnosed with a T1-T2 oral squamous cell carcinoma and clinically negative (N0) neck in a single center. METHODS: A retrospective analysis of 90 previously untreated patients who underwent SNB between 2007 and 2012 was performed. The SNB procedure consisted of preoperatively performed lymphoscintigraphy, intraoperative detection using blue dye, and gamma probe guidance and histopathologic examination including step-serial sectioning (SSS) and immunohistochemical (IHC) staining...
April 2015: Head & Neck
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