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oral squamous cell cancer sentinel

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https://www.readbyqxmd.com/read/27878928/sentinel-lymph-node-biopsy-for-early-oral-cancers-westmead-hospital-experience
#1
Muzib Abdul-Razak, Hsiang Chung, Eva Wong, Carsten Palme, Michael Veness, David Farlow, Hedley Coleman, Gary Morgan
BACKGROUND: Sentinel lymph node biopsy (SLNB) has become an alternative option to elective neck dissection (END) for early oral cavity squamous cell carcinoma (OCSCC) outside of Australia. We sought to assess the technical feasibility of SLNB and validate its accuracy against that of END in an Australian setting. METHODS: We performed a prospective cohort study consisting of 30 consecutive patients with cT1-2 N0 OCSCC referred to the Head and Neck Cancer Service, Westmead Hospital, Sydney, between 2011 and 2014...
November 23, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27872522/sentinel-lymph-node-biopsy-in-n0-neck-for-squamous-cell-carcinoma-of-oral-cavity-a-prospective-study
#2
K Shivakumar, Goel Vipin, Manjunath Suraj, B V Rajaram, Ramesh Rakesh, A Anuradha, K Hemanth
Oral cancers in India are very common. SLNB (sentinel lymph node biopsy) for the management of the cN0 neck provides proper staging with less morbidity. The study aims at assessment of the technical feasibility and accuracy of SLNB. Two by two table and Kappa statistic was used to compare SLN and END. In 14 cases out of 16 cases, SLN was identified. Sensitivity and specificity of 100 % were found. One hundred percent agreement was observed between SLN and END using kappa statistics. A meta-analysis of 19 studies showed 97...
December 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27842990/review-of-sentinel-node-procedure-in-cn0-head-and-neck-squamous-cell-carcinomas-guidelines-from-the-french-evaluation-cooperative-subgroup-of-gettec
#3
R Garrel, G Poissonnet, S Temam, G Dolivet, N Fakhry, D de Raucourt
The reliability of the sentinel lymph node (SN) technique has been established for more than ten years in T1-T2 oral cavity and oropharynx squamous cell carcinoma. Although most authors stress the necessity of rigorous implementation, there are no agreed guidelines. Moreover, other indications have been described, in other anatomical areas of the upper aerodigestive tract and in case of previous surgery or radiotherapy. SN expert teams, under the GETTEC head and neck tumor study group, conducted a review of the key points for implementation in head and neck cancers through guidelines and a review of classical and extended indications...
November 11, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/27496008/sentinel-node-biopsy-for-oral-cancer-a-prospective-multicenter-phase-ii-trial
#4
Kouki Miura, Hitoshi Hirakawa, Hirokazu Uemura, Seiichi Yoshimoto, Akihiro Shiotani, Masashi Sugasawa, Akihiro Homma, Junkichi Yokoyama, Kiyoaki Tsukahara, Tomokazu Yoshizaki, Yasushi Yatabe, Keitaro Matsuo, Yasuo Ohkura, Shigeru Kosuda, Yasuhisa Hasegawa
OBJECTIVE: A recent study identified a survival benefit with prophylactic neck dissection (ND) at the time of primary surgery as compared with watchful waiting followed by therapeutic neck dissection for nodal relapse, in patients with cN0 oral squamous cell carcinoma (OSCC). Alternative management of cN0 neck cancer is recommended to minimize the adverse effects of ND, indicating the need for sentinel node biopsy (SNB) and limited neck dissection. We conducted a multicenter Phase II study to examine the feasibility of SNB for clinically N0 OSCC...
August 2, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27330766/sentinel-lymph-node-biopsy-reduces-the-incidence-of-secondary-neck-metastasis-in-patients-with-oral-squamous-cell-carcinoma
#5
Akimitsu Hiraki, Daiki Fukuma, Masashi Nagata, Shinya Shiraishi, Kenta Kawahara, Yuichiro Matsuoka, Yoshihiro Nakagawa, Ryoji Yoshida, Takuya Tanaka, Yoshihiro Yoshitake, Masanori Shinohara, Yasuyuki Yamashita, Hideki Nakayama
It has recently been established that sentinel node biopsy (SNB) is an applicable and feasible procedure for the prediction of neck lymph node status in patients with early oral squamous cell carcinoma (OSCC) who are clinically negative for neck metastasis (cN0). The aim of this study was to retrospectively compare excision followed by watchful waiting with excision and SNB, in order to determine the effectiveness of SNB. A total of 125 patients with cN0 early OSCC were divided into two groups, namely the excision alone (n=78) and excision with SNB (n=47) groups...
July 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27088386/sentinel-node-in-oral-cancer-the-nuclear-medicine-aspects-a-survey-from-the-sentinel-european-node-trial
#6
Girolamo Tartaglione, Sandro J Stoeckli, Remco de Bree, Clare Schilling, Geke B Flach, Vivi Bakholdt, Jens Ahm Sorensen, Anders Bilde, Christian von Buchwald, Georges Lawson, Didier Dequanter, Pedro M Villarreal, Manuel Florentino Fresno Forcelledo, Julio Alvarez Amezaga, Augusto Moreira, Tito Poli, Cesare Grandi, Maurizio Giovanni Vigili, Michael O'Doherty, Davide Donner, Elisabeth Bloemena, Siavash Rahimi, Benjamin Gurney, Stephan K Haerle, Martina A Broglie, Gerhard F Huber, Annelise L Krogdah, Lars R Sebbesen, Edward Odell, Luis Manuel Junquera Gutierrez, Luis Barbier, Joseba Santamaria-Zuazua, Manuel Jacome, Marie-Cecile Nollevaux, Emma Bragantini, Philippe Lothaire, Enrico M Silini, Enrico Sesenna, Giles Dolivet, Romina Mastronicola, Agnes Leroux, Isabel Sassoon, Philip Sloan, Patrick M Colletti, Domenico Rubello, Mark McGurk
PURPOSE: Nuclear imaging plays a crucial role in lymphatic mapping of oral cancer. This evaluation represents a subanalysis of the original multicenter SENT trial data set, involving 434 patients with T1-T2, N0, and M0 oral squamous cell carcinoma. The impact of acquisition techniques, tracer injection timing relative to surgery, and causes of false-negative rate were assessed. METHODS: Three to 24 hours before surgery, all patients received a dose of Tc-nanocolloid (10-175 MBq), followed by lymphoscintigraphy...
July 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/26700817/annexin-a8-is-a-novel-molecular-marker-for-detecting-lymph-node-metastasis-in-oral-squamous-cell-carcinoma
#7
COMPARATIVE STUDY
Ryota Oka, Koh-Ichi Nakashiro, Hiroyuki Goda, Kazuki Iwamoto, Norihiko Tokuzen, Hiroyuki Hamakawa
Cervical lymph node metastasis is an important prognostic factor in oral squamous cell carcinoma (OSCC), but its accurate assessment after sentinel node biopsy or neck dissection is often limited to the histopathological examination of only one or two sections. Previous our study showed the usefulness of the reverse transcription loop-mediated isothermal amplification (RT-LAMP) targeting keratin 19 (KRT19) mRNA for the genetic detection of lymph node metastasis, but the sensitivity was insufficient. Here, we have attempted to identify novel molecular markers for OSCC cells in lymph nodes...
January 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/26597442/sentinel-european-node-trial-sent-3-year-results-of-sentinel-node-biopsy-in-oral-cancer
#8
MULTICENTER STUDY
Clare Schilling, Sandro J Stoeckli, Stephan K Haerle, Martina A Broglie, Gerhard F Huber, Jens Ahm Sorensen, Vivi Bakholdt, Annelise Krogdahl, Christian von Buchwald, Anders Bilde, Lars R Sebbesen, Edward Odell, Benjamin Gurney, Michael O'Doherty, Remco de Bree, Elisabeth Bloemena, Geke B Flach, Pedro M Villarreal, Manuel Florentino Fresno Forcelledo, Luis Manuel Junquera Gutiérrez, Julio Alvarez Amézaga, Luis Barbier, Joseba Santamaría-Zuazua, Augusto Moreira, Manuel Jacome, Maurizio Giovanni Vigili, Siavash Rahimi, Girolamo Tartaglione, Georges Lawson, Marie-Cecile Nollevaux, Cesare Grandi, Davide Donner, Emma Bragantini, Didier Dequanter, Philippe Lothaire, Tito Poli, Enrico M Silini, Erinco Sesenna, Giles Dolivet, Romina Mastronicola, Agnes Leroux, Isabel Sassoon, Philip Sloan, Mark McGurk
PURPOSE: Optimum management of the N0 neck is unresolved in oral cancer. Sentinel node biopsy (SNB) can reliably detect microscopic lymph node metastasis. The object of this study was to establish whether the technique was both reliable in staging the N0 neck and a safe oncological procedure in patients with early-stage oral squamous cell carcinoma. METHODS: An European Organisation for Research and Treatment of Cancer-approved prospective, observational study commenced in 2005...
December 2015: European Journal of Cancer
https://www.readbyqxmd.com/read/26467454/feasibility-of-real-time-near-infrared-fluorescence-tracer-imaging-in-sentinel-node-biopsy-for-oral-cavity-cancer-patients
#9
Anders Christensen, Karina Juhl, Birgitte Charabi, Jann Mortensen, Katalin Kiss, Andreas Kjær, Christian von Buchwald
BACKGROUND: Sentinel node biopsy (SNB) is an established method in oral squamous cell carcinoma (OSCC) for staging the cN0 neck and to select patients who will benefit from a neck dissection. Near-infrared fluorescence (NIRF) imaging has the potential to improve the SNB procedure by facilitating intraoperative visual identification of the sentinel lymph node (SN). The purpose of this study was to evaluate the feasibility of fluorescence tracer imaging for SN detection in conjunction with conventional radio-guided technique...
February 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/26209419/double-sentinel-lymph-node-mapping-with-indocyanine-green-and-99m-technetium-tin-colloid-in-oral-squamous-cell-carcinoma
#10
R Murase, H Tanaka, T Hamakawa, H Goda, T Tano, A Ishikawa, S Hino, T Sumida, K Nakashiro, H Hamakawa
Oral squamous cell carcinoma (OSCC) frequently metastasizes to cervical lymph nodes, which is the most known prognostic factor. Screening methods to identify sentinel lymph nodes (SLNs) are therefore of great interest for the management of potential neck metastasis. The purpose of this study was to evaluate the clinical benefit of double SLN mapping with indocyanine green (ICG) and 99m-technetium-tin colloid ((99m)Tc-tin colloid) for sentinel node navigation surgery (SNNS). Between 2007 and 2010, 16 patients diagnosed with OSCC were investigated by SLN biopsy using the double mapping method...
October 2015: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/26198548/quality-of-life-after-different-procedures-for-regional-control-in-oral-cancer-patients-cross-sectional-survey
#11
T M Govers, W H Schreuder, W M C Klop, J P C Grutters, M M Rovers, M A W Merkx, R P Takes
OBJECTIVES: To examine health utilities in patients with cT1-2 oral cavity squamous cell carcinoma following different diagnostic and treatment modalities for the neck and to investigate the relation between shoulder morbidity and health utility. DESIGN: Cross-sectional survey. SETTING: Two Dutch hospitals. PARTICIPANTS: Four subgroups of patients with oral cavity cancer who underwent watchful waiting, sentinel lymph node biopsy, elective supraomohyoid neck dissection or therapeutic modified radical neck dissection...
June 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/26040238/staging-of-early-lymph-node-metastases-with-the-sentinel-lymph-node-technique-and-predictive-factors-in-t1-t2-oral-cavity-cancer-a-retrospective-single-center-study
#12
Nicklas Juel Pedersen, David Hebbelstrup Jensen, Nora Hedbäck, Martin Frendø, Katalin Kiss, Giedrius Lelkaitis, Jann Mortensen, Anders Christensen, Lena Specht, Christian von Buchwald
BACKGROUND: The purpose of this study was to examine the diagnostic accuracy of detecting lymph node metastases and to identify predictive and prognostic clinicopathological factors in patients with oral squamous cell carcinoma (OSCC) undergoing sentinel lymph node biopsy (SLNB). METHODS: All patients diagnosed with cT1 to T2N0 OSCC who underwent a diagnostic SLNB between 2007 and 2013 were included. RESULTS: We identified 253 patients, of whom 27% had a positive sentinel lymph node (SLB)...
April 2016: Head & Neck
https://www.readbyqxmd.com/read/25956693/99mtc-tilmanocept-a-novel-molecular-agent-for-lymphatic-mapping-and-sentinel-lymph-node-localization
#13
REVIEW
Devaki Shilpa Surasi, Janis O'Malley, Pradeep Bhambhvani
Preoperative lymphatic mapping in conjunction with intraoperative γ-probe detection is widely used for sentinel node localization in melanoma, breast cancer, and other malignancies. (99m)Tc-radiocolloids have been the standard radiotracers used for sentinel node mapping. (99m)Tc-tilmanocept is a receptor-binding molecular imaging agent approved by the U.S. Food and Drug Administration for lymphatic mapping and lymph node localization in breast cancer, melanoma, clinically node-negative squamous cell carcinoma of the oral cavity, and other solid tumors...
June 2015: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/25749001/lymphatic-drainage-patterns-in-oral-squamous-cell-carcinoma-findings-of-the-acosog-z0360-alliance-study
#14
Roger W Farmer, Linda McCall, Francisco J Civantos, Jeffrey N Myers, Wendell G Yarbrough, Barbara Murphy, Miriam O'Leary, Robert Zitsch, Barry A Siegel
OBJECTIVE: The purpose of our study was to correlate sentinel lymph nodes (SLN) found on planar lymphoscintigraphy (LS) to SLN found with gamma probe-directed sentinel lymph node biopsy (SLNB) for T1/T2 N0 oral cavity cancer. STUDY DESIGN: Prospective cooperative group trial. SETTING: Academic medical centers. SUBJECTS AND METHODS: One hundred forty adults with untreated T1/T2 N0 squamous cell carcinoma (SCC) of the oral cavity underwent planar LS, resection, SLNB, and neck dissection...
April 2015: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/25419060/a-prospective-study-on-sentinel-lymph-node-biopsy-in-early-oral-cancers-using-methylene-blue-dye-alone
#15
Rajaraman Ramamurthy, Rajkumar Kottayasamy Seenivasagam, Subbiah Shanmugam, Kathirvelkumaran Palanivelu
Sentinel Lymph Node (SLN) biopsy using a combination of radioisotopes and blue dyes have a good accuracy rate in predicting subclinical neck nodal metastases in head and neck cancers. However, the limited availability of lymphoscintigraphy facilities in India requires exploration of alternative methods of SLN detection. We evaluated the feasibility of using methylene blue dye alone in detecting SLN in cN0 early oral cancers. 32 patients with cN0 early (T1, T2) oral squamous cell cancers underwent SLN biopsy using peri tumoural methylene blue dye injection...
September 2014: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25106426/sentinel-lymph-node-biopsy-revisited-ultrasound-guided-photoacoustic-detection-of-micrometastases-using-molecularly-targeted-plasmonic-nanosensors
#16
Geoffrey P Luke, Jeffrey N Myers, Stanislav Y Emelianov, Konstantin V Sokolov
Metastases rather than primary tumors are responsible for killing most patients with cancer. Cancer cells often invade regional lymph nodes (LN) before colonizing other parts of the body. However, due to the low sensitivity and specificity of current imaging methods to detect localized nodal spread, an invasive surgical procedure--sentinel LN biopsy--is generally used to identify metastatic cancer cells. Here, we introduce a new approach for more sensitive in vivo detection of LN micrometastases, based on the use of ultrasound-guided spectroscopic photoacoustic (sPA) imaging of molecularly activated plasmonic nanosensors (MAPS)...
October 1, 2014: Cancer Research
https://www.readbyqxmd.com/read/25077931/intraoperative-3-d-imaging-improves-sentinel-lymph-node-biopsy-in-oral-cancer
#17
Christina Bluemel, Ken Herrmann, Alexander Kübler, Andreas K Buck, Eva Geissinger, Vanessa Wild, Stefan Hartmann, Constantin Lapa, Christian Linz, Urs Müller-Richter
PURPOSE: The aim of this study was to prospectively evaluate the feasibility and potential advantages of freehand single-photon emission computed tomography (fhSPECT) compared with conventional intraoperative localization techniques for sentinel lymph node biopsy (SLNB) in oral cancer. METHODS: Between November 2012 and February 2014, 23 consecutive patients with clinical T1/T2 oral squamous cell carcinoma and a cN0 neck were recruited. All patients underwent SLNB followed by elective neck dissection (END)...
December 2014: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/24948411/maxillary-squamous-cell-carcinoma-an-11-year-retrospective-study-of-one-regional-cancer-centre
#18
J Philip, R James
Intraoral maxillary squamous cell carcinoma (IOMSCC) tumours are comparatively rare compared to those occurring at other oral sites. This has resulted in limited studies regarding their pattern of local and regional behaviour. In a review of the IOMSCC cohort (N=39) at the study institution, IOMSCC was found to demonstrate a pattern of levels 1-3 nodal disease in the N+ neck at presentation (33.3%), with a total metastatic rate of 46.1%, which is similar to that for other intraoral sites. IOMSCC demonstrated metastatic potential to the contralateral neck, with 20% of patients progressing to present with disease...
October 2014: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/24908285/oral-cavity-squamous-cell-carcinoma-role-of-pretreatment-imaging-and-its-influence-on-management
#19
S Arya, P Rane, A Deshmukh
Squamous cell carcinoma (SCC) is the commonest malignancy in the oral cavity. The oral cavity has several subsites. Knowledge of the patterns of disease spread at each subsite with the impact on treatment and prognosis provides a deeper understanding of the role of imaging. Information from imaging helps accurate staging, assess resectability, and plan multimodality treatment. Mandibular erosion, posterior soft tissue extent, and perineural spread influence treatment and prognosis in gingival, buccal, and retromolar trigone (RMT) cancers...
September 2014: Clinical Radiology
https://www.readbyqxmd.com/read/24890924/prospective-study-of-ultrasound-guided-fine-needle-aspiration-cytology-and-sentinel-node-biopsy-in-the-staging-of-clinically-negative-t1-and-t2-oral-cancer
#20
Pankaj Chaturvedi, Sourav Datta, Supreeta Arya, Venkatesh Rangarajan, Shubhada V Kane, Deepa Nair, Sudhir Nair, Devendra A Chaukar, Prathamesh S Pai, Gouri Pantvaidya, Anuja D Deshmukh, Archi Agrawal, Anil K D'Cruz
BACKGROUND: The purpose of this study was to compare sentinel node biopsy (SNB) and ultrasound-guided fine-needle aspiration cytology (FNAC) for preoperative evaluation of the N0 neck in T1 to T2 oral cavity squamous cell carcinoma (SCC). METHODS: Fifty-one consecutive patients with T1 to T2 N0 oral cavity SCC were included in this study. Preoperative ultrasound was performed in all patients. Ultrasound-guided FNAC was performed in patients in whom the ultrasound result was reported as indeterminate or positive...
October 2015: Head & Neck
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