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oral squamous cell cancer sentinel

Manish Chand, Deborah S Keller, Laurence Devoto, Mark McGurk
To describe an innovative sentinel lymph node (SLN) guidance approach using a radionuclide tracer, 3D augmented reality-guided imaging, and near infrared (NIR) fluorescence over-lay imaging with hand-held probes to optimize accuracy, efficiency, and precise navigation for sentinel node (SN) localization in head and neck cancer. In a cT1N0M0 squamous cell carcinoma of the tongue, pre-operative radionuclide lymphoscintigraphy was performed with a sentinel node-specific radiolabeled tracer. Intraoperatively, a 3D hand-held augmented reality (AR) scanning SPECT probe assessed concordance of the SN with pre-operative SPECT-CT images...
January 22, 2018: Journal of Fluorescence
Valtteri Häyry, Åsa Kågedal, Eric Hjalmarsson, Pedro Farrajota Neves da Silva, Cecilia Drakskog, Gregori Margolin, Susanna Kumlien Georén, Eva Munck-Wikland, Ola Winqvist, Lars Olaf Cardell
BACKGROUND: Detection of metastatic spread of head and neck cancer to cervical lymph nodes is essential for optimal design of therapy. Undetected metastases lead to mortality, which can be prevented by better detection methods. METHODS: We analysed 41 lymph nodes from 19 patients with oral squamous cell carcinoma (OSCC). Each lymph node was divided in two, one half processed for histopathology and the other half dissociated into single-cell suspension, stained for the carcinoma cell markers cytokeratin 5/8 (CK5/8), epithelial cell adhesion molecule (EpCAM) and epithelial mucin (MUC-1), and analysed with flow cytometry...
February 6, 2018: British Journal of Cancer
S R Gvetadze, M Lv, K D Ilkaev, P Xiong, J Li, X Yang, J Sun
The paper describes properties of clinical visualization approaches which are applied for detection of sentinel lymph nodes in patients suffering from oral cavity squamous cell cancer. Diagnostic efficiency results and technological features of different imaging techniques are discussed.
2017: Stomatologii︠a︡
Deepti Sharma, George Koshy, Sonal Grover, Bhushan Sharma
Cervical lymph node metastasis affects the prognosis and overall survival rate of and therapeutic planning for patients with head and neck squamous cell carcinomas (HNSCCs). However, advanced diagnostic modalities still lack accuracy in detecting occult neck metastasis. A sentinel lymph node biopsy is a minimally invasive auxiliary method for assessing the presence of occult metastatic disease in a patient with a clinically negative neck. This technique increases the specificity of neck dissection and thus reduces morbidity among oral cancer patients...
February 2017: Sultan Qaboos University Medical Journal
Muzib Abdul-Razak, Hsiang Chung, Eva Wong, Carsten Palme, Michael Veness, David Farlow, Hedley Coleman, Gary Morgan
BACKGROUND: Sentinel lymph node biopsy (SLNB) has become an alternative option to elective neck dissection (END) for early oral cavity squamous cell carcinoma (OCSCC) outside of Australia. We sought to assess the technical feasibility of SLNB and validate its accuracy against that of END in an Australian setting. METHODS: We performed a prospective cohort study consisting of 30 consecutive patients with cT1-2 N0 OCSCC referred to the Head and Neck Cancer Service, Westmead Hospital, Sydney, between 2011 and 2014...
January 2017: ANZ Journal of Surgery
K Shivakumar, Goel Vipin, Manjunath Suraj, B V Rajaram, Ramesh Rakesh, A Anuradha, K Hemanth
Oral cancers in India are very common. SLNB (sentinel lymph node biopsy) for the management of the cN0 neck provides proper staging with less morbidity. The study aims at assessment of the technical feasibility and accuracy of SLNB. Two by two table and Kappa statistic was used to compare SLN and END. In 14 cases out of 16 cases, SLN was identified. Sensitivity and specificity of 100 % were found. One hundred percent agreement was observed between SLN and END using kappa statistics. A meta-analysis of 19 studies showed 97...
December 2016: Indian Journal of Surgical Oncology
R Garrel, G Poissonnet, S Temam, G Dolivet, N Fakhry, D de Raucourt
The reliability of the sentinel lymph node (SN) technique has been established for more than ten years in T1-T2 oral cavity and oropharynx squamous cell carcinoma. Although most authors stress the necessity of rigorous implementation, there are no agreed guidelines. Moreover, other indications have been described, in other anatomical areas of the upper aerodigestive tract and in case of previous surgery or radiotherapy. SN expert teams, under the GETTEC head and neck tumor study group, conducted a review of the key points for implementation in head and neck cancers through guidelines and a review of classical and extended indications...
November 11, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
Kouki Miura, Hitoshi Hirakawa, Hirokazu Uemura, Seiichi Yoshimoto, Akihiro Shiotani, Masashi Sugasawa, Akihiro Homma, Junkichi Yokoyama, Kiyoaki Tsukahara, Tomokazu Yoshizaki, Yasushi Yatabe, Keitaro Matsuo, Yasuo Ohkura, Shigeru Kosuda, Yasuhisa Hasegawa
OBJECTIVE: A recent study identified a survival benefit with prophylactic neck dissection (ND) at the time of primary surgery as compared with watchful waiting followed by therapeutic neck dissection for nodal relapse, in patients with cN0 oral squamous cell carcinoma (OSCC). Alternative management of cN0 neck cancer is recommended to minimize the adverse effects of ND, indicating the need for sentinel node biopsy (SNB) and limited neck dissection. We conducted a multicenter Phase II study to examine the feasibility of SNB for clinically N0 OSCC...
June 2017: Auris, Nasus, Larynx
Akimitsu Hiraki, Daiki Fukuma, Masashi Nagata, Shinya Shiraishi, Kenta Kawahara, Yuichiro Matsuoka, Yoshihiro Nakagawa, Ryoji Yoshida, Takuya Tanaka, Yoshihiro Yoshitake, Masanori Shinohara, Yasuyuki Yamashita, Hideki Nakayama
It has recently been established that sentinel node biopsy (SNB) is an applicable and feasible procedure for the prediction of neck lymph node status in patients with early oral squamous cell carcinoma (OSCC) who are clinically negative for neck metastasis (cN0). The aim of this study was to retrospectively compare excision followed by watchful waiting with excision and SNB, in order to determine the effectiveness of SNB. A total of 125 patients with cN0 early OSCC were divided into two groups, namely the excision alone (n=78) and excision with SNB (n=47) groups...
July 2016: Molecular and Clinical Oncology
Girolamo Tartaglione, Sandro J Stoeckli, Remco de Bree, Clare Schilling, Geke B Flach, Vivi Bakholdt, Jens Ahm Sorensen, Anders Bilde, Christian von Buchwald, Georges Lawson, Didier Dequanter, Pedro M Villarreal, Manuel Florentino Fresno Forcelledo, Julio Alvarez Amezaga, Augusto Moreira, Tito Poli, Cesare Grandi, Maurizio Giovanni Vigili, Michael O'Doherty, Davide Donner, Elisabeth Bloemena, Siavash Rahimi, Benjamin Gurney, Stephan K Haerle, Martina A Broglie, Gerhard F Huber, Annelise L Krogdah, Lars R Sebbesen, Edward Odell, Luis Manuel Junquera Gutierrez, Luis Barbier, Joseba Santamaria-Zuazua, Manuel Jacome, Marie-Cecile Nollevaux, Emma Bragantini, Philippe Lothaire, Enrico M Silini, Enrico Sesenna, Giles Dolivet, Romina Mastronicola, Agnes Leroux, Isabel Sassoon, Philip Sloan, Patrick M Colletti, Domenico Rubello, Mark McGurk
PURPOSE: Nuclear imaging plays a crucial role in lymphatic mapping of oral cancer. This evaluation represents a subanalysis of the original multicenter SENT trial data set, involving 434 patients with T1-T2, N0, and M0 oral squamous cell carcinoma. The impact of acquisition techniques, tracer injection timing relative to surgery, and causes of false-negative rate were assessed. METHODS: Three to 24 hours before surgery, all patients received a dose of Tc-nanocolloid (10-175 MBq), followed by lymphoscintigraphy...
July 2016: Clinical Nuclear Medicine
Ryota Oka, Koh-Ichi Nakashiro, Hiroyuki Goda, Kazuki Iwamoto, Norihiko Tokuzen, Hiroyuki Hamakawa
Cervical lymph node metastasis is an important prognostic factor in oral squamous cell carcinoma (OSCC), but its accurate assessment after sentinel node biopsy or neck dissection is often limited to the histopathological examination of only one or two sections. Previous our study showed the usefulness of the reverse transcription loop-mediated isothermal amplification (RT-LAMP) targeting keratin 19 (KRT19) mRNA for the genetic detection of lymph node metastasis, but the sensitivity was insufficient. Here, we have attempted to identify novel molecular markers for OSCC cells in lymph nodes...
January 26, 2016: Oncotarget
Clare Schilling, Sandro J Stoeckli, Stephan K Haerle, Martina A Broglie, Gerhard F Huber, Jens Ahm Sorensen, Vivi Bakholdt, Annelise Krogdahl, Christian von Buchwald, Anders Bilde, Lars R Sebbesen, Edward Odell, Benjamin Gurney, Michael O'Doherty, Remco de Bree, Elisabeth Bloemena, Geke B Flach, Pedro M Villarreal, Manuel Florentino Fresno Forcelledo, Luis Manuel Junquera Gutiérrez, Julio Alvarez Amézaga, Luis Barbier, Joseba Santamaría-Zuazua, Augusto Moreira, Manuel Jacome, Maurizio Giovanni Vigili, Siavash Rahimi, Girolamo Tartaglione, Georges Lawson, Marie-Cecile Nollevaux, Cesare Grandi, Davide Donner, Emma Bragantini, Didier Dequanter, Philippe Lothaire, Tito Poli, Enrico M Silini, Erinco Sesenna, Giles Dolivet, Romina Mastronicola, Agnes Leroux, Isabel Sassoon, Philip Sloan, Mark McGurk
PURPOSE: Optimum management of the N0 neck is unresolved in oral cancer. Sentinel node biopsy (SNB) can reliably detect microscopic lymph node metastasis. The object of this study was to establish whether the technique was both reliable in staging the N0 neck and a safe oncological procedure in patients with early-stage oral squamous cell carcinoma. METHODS: An European Organisation for Research and Treatment of Cancer-approved prospective, observational study commenced in 2005...
December 2015: European Journal of Cancer
Anders Christensen, Karina Juhl, Birgitte Charabi, Jann Mortensen, Katalin Kiss, Andreas Kjær, Christian von Buchwald
BACKGROUND: Sentinel node biopsy (SNB) is an established method in oral squamous cell carcinoma (OSCC) for staging the cN0 neck and to select patients who will benefit from a neck dissection. Near-infrared fluorescence (NIRF) imaging has the potential to improve the SNB procedure by facilitating intraoperative visual identification of the sentinel lymph node (SN). The purpose of this study was to evaluate the feasibility of fluorescence tracer imaging for SN detection in conjunction with conventional radio-guided technique...
February 2016: Annals of Surgical Oncology
R Murase, H Tanaka, T Hamakawa, H Goda, T Tano, A Ishikawa, S Hino, T Sumida, K Nakashiro, H Hamakawa
Oral squamous cell carcinoma (OSCC) frequently metastasizes to cervical lymph nodes, which is the most known prognostic factor. Screening methods to identify sentinel lymph nodes (SLNs) are therefore of great interest for the management of potential neck metastasis. The purpose of this study was to evaluate the clinical benefit of double SLN mapping with indocyanine green (ICG) and 99m-technetium-tin colloid ((99m)Tc-tin colloid) for sentinel node navigation surgery (SNNS). Between 2007 and 2010, 16 patients diagnosed with OSCC were investigated by SLN biopsy using the double mapping method...
October 2015: International Journal of Oral and Maxillofacial Surgery
T M Govers, W H Schreuder, W M C Klop, J P C Grutters, M M Rovers, M A W Merkx, R P Takes
OBJECTIVES: To examine health utilities in patients with cT1-2 oral cavity squamous cell carcinoma following different diagnostic and treatment modalities for the neck and to investigate the relation between shoulder morbidity and health utility. DESIGN: Cross-sectional survey. SETTING: Two Dutch hospitals. PARTICIPANTS: Four subgroups of patients with oral cavity cancer who underwent watchful waiting, sentinel lymph node biopsy, elective supraomohyoid neck dissection or therapeutic modified radical neck dissection...
June 2016: Clinical Otolaryngology
Nicklas Juel Pedersen, David Hebbelstrup Jensen, Nora Hedbäck, Martin Frendø, Katalin Kiss, Giedrius Lelkaitis, Jann Mortensen, Anders Christensen, Lena Specht, Christian von Buchwald
BACKGROUND: The purpose of this study was to examine the diagnostic accuracy of detecting lymph node metastases and to identify predictive and prognostic clinicopathological factors in patients with oral squamous cell carcinoma (OSCC) undergoing sentinel lymph node biopsy (SLNB). METHODS: All patients diagnosed with cT1 to T2N0 OSCC who underwent a diagnostic SLNB between 2007 and 2013 were included. RESULTS: We identified 253 patients, of whom 27% had a positive sentinel lymph node (SLB)...
April 2016: Head & Neck
Devaki Shilpa Surasi, Janis O'Malley, Pradeep Bhambhvani
Preoperative lymphatic mapping in conjunction with intraoperative γ-probe detection is widely used for sentinel node localization in melanoma, breast cancer, and other malignancies. (99m)Tc-radiocolloids have been the standard radiotracers used for sentinel node mapping. (99m)Tc-tilmanocept is a receptor-binding molecular imaging agent approved by the U.S. Food and Drug Administration for lymphatic mapping and lymph node localization in breast cancer, melanoma, clinically node-negative squamous cell carcinoma of the oral cavity, and other solid tumors...
June 2015: Journal of Nuclear Medicine Technology
Roger W Farmer, Linda McCall, Francisco J Civantos, Jeffrey N Myers, Wendell G Yarbrough, Barbara Murphy, Miriam O'Leary, Robert Zitsch, Barry A Siegel
OBJECTIVE: The purpose of our study was to correlate sentinel lymph nodes (SLN) found on planar lymphoscintigraphy (LS) to SLN found with gamma probe-directed sentinel lymph node biopsy (SLNB) for T1/T2 N0 oral cavity cancer. STUDY DESIGN: Prospective cooperative group trial. SETTING: Academic medical centers. SUBJECTS AND METHODS: One hundred forty adults with untreated T1/T2 N0 squamous cell carcinoma (SCC) of the oral cavity underwent planar LS, resection, SLNB, and neck dissection...
April 2015: Otolaryngology—Head and Neck Surgery
Rajaraman Ramamurthy, Rajkumar Kottayasamy Seenivasagam, Subbiah Shanmugam, Kathirvelkumaran Palanivelu
Sentinel Lymph Node (SLN) biopsy using a combination of radioisotopes and blue dyes have a good accuracy rate in predicting subclinical neck nodal metastases in head and neck cancers. However, the limited availability of lymphoscintigraphy facilities in India requires exploration of alternative methods of SLN detection. We evaluated the feasibility of using methylene blue dye alone in detecting SLN in cN0 early oral cancers. 32 patients with cN0 early (T1, T2) oral squamous cell cancers underwent SLN biopsy using peri tumoural methylene blue dye injection...
September 2014: Indian Journal of Surgical Oncology
Geoffrey P Luke, Jeffrey N Myers, Stanislav Y Emelianov, Konstantin V Sokolov
Metastases rather than primary tumors are responsible for killing most patients with cancer. Cancer cells often invade regional lymph nodes (LN) before colonizing other parts of the body. However, due to the low sensitivity and specificity of current imaging methods to detect localized nodal spread, an invasive surgical procedure--sentinel LN biopsy--is generally used to identify metastatic cancer cells. Here, we introduce a new approach for more sensitive in vivo detection of LN micrometastases, based on the use of ultrasound-guided spectroscopic photoacoustic (sPA) imaging of molecularly activated plasmonic nanosensors (MAPS)...
October 1, 2014: Cancer Research
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