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https://www.readbyqxmd.com/read/29457878/genetic-determinants-of-heart-failure-facts-and-numbers
#1
EDITORIAL
Frauke S Czepluch, Bernd Wollnik, Gerd Hasenfuß
The relevance of gene mutations leading to heart diseases and hence heart failure has become evident. The risk for and the course of heart failure depends on genomic variants and mutations underlying the so-called genetic predisposition. Genetic contribution to heart failure is highly heterogenous and complex. For any patient with a likely inherited heart failure syndrome, genetic counselling is recommended and important. In the last few years, novel sequencing technologies (named next-generation sequencing - NGS) have dramatically improved the availability of molecular testing, the efficiency of genetic analyses, and moreover reduced the cost for genetic testing...
February 19, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29457808/cds-nanosphere-decorated-hollow-polyhedral-zco-derived-from-a-metal-organic-framework-mof-for-effective-photocatalytic-water-evolution
#2
Wenxia Chen, Jiasheng Fang, Yiwei Zhang, Guangliang Chen, Shuo Zhao, Chao Zhang, Ran Xu, Jiehua Bao, Yuming Zhou, Xin Xiang
Semiconductor nanostructures have received considerable attention in the field of photocatalytic hydrogen evolution. However, eco-friendly, high efficiency, and low-cost semiconductor materials are still desired. In consideration of this, herein, we design a new and economic noble-metal-free CdS/Znx Co3-x O4 (CdS/ZCO) nanohybrid photocatalyst using a metal-organic framework (MOF) template, which is a framework structure composed of organic ligands and metal ion nodes with different numbers of connections. The as-prepared CdS/ZCO composites with a large specific surface area and porous hollow structure exhibit remarkable catalytic activity and high stability for hydrogen generation...
February 19, 2018: Nanoscale
https://www.readbyqxmd.com/read/29457632/rapid-eradication-of-bacterial-phytopathogens-by-atmospheric-pressure-glow-discharge-generated-in-contact-with-a-flowing-liquid-cathode
#3
Agata Motyka, Anna Dzimitrowicz, Piotr Jamroz, Ewa Lojkowska, Wojciech Sledz, Pawel Pohl
Diseases caused by phytopathogenic bacteria are responsible for significant economic losses, and these bacteria spread through diverse pathways including waterways and industrial wastes. It is therefore of interest to develop potent methods for their eradication. Here, antibacterial properties of direct current atmospheric pressure glow discharge (dc-APGD) generated in contact with flowing bacterial suspensions were examined against five species of phytopathogens. Complete eradication of Clavibacter michiganensis subsp...
February 19, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29457631/non-invasive-genetic-censusing-and-monitoring-of-primate-populations
#4
REVIEW
Mimi Arandjelovic, Linda Vigilant
Knowing the density or abundance of primate populations is essential for their conservation management and contextualizing socio-demographic and behavioral observations. When direct counts of animals are not possible, genetic analysis of non-invasive samples collected from wildlife populations allows estimates of population size with higher accuracy and precision than is possible using indirect signs. Furthermore, in contrast to traditional indirect survey methods, prolonged or periodic genetic sampling across months or years enables inference of group membership, movement, dynamics, and some kin relationships...
February 19, 2018: American Journal of Primatology
https://www.readbyqxmd.com/read/29457446/roll-to-roll-printing-of-meter-scale-composite-transparent-electrodes-with-optimized-mechanical-and-optical-properties-for-photoelectronics
#5
Xiangchuan Meng, Xiaotian Hu, Xia Yang, Jingping Yin, Qingxia Wang, Liqiang Huang, Zoukangning Yu, Ting Hu, Licheng Tan, Weihua Zhou, Yiwang Chen
Flexible transparent electrodes (FTEs) are an indispensable component for flexible optoelectronic devices. In this work, the meter-scale composite transparent electrode (CTEs) composing of poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) and Ag-grid/PET with optimized mechanical and optical properties is demonstrated by slot-die roll-to-roll technique with solution printing method under a low cost (2.8 $ for per square meter), via control of the viscosity and surface energy of PEDOT:PSS ink as well as the printing parameters...
February 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29456815/crispr-cas9-a-new-approach-to-successful-knockdown-of-abcb1-p-glycoprotein-and-reversal-of-chemosensitivity-in-human-epithelial-ovarian-cancer-cell-line
#6
Leyla Norouzi-Barough, Mohammadreza Sarookhani, Rasoul Salehi, Mohammadreza Sharifi, Sahar Moghbelinejad
Objectives: Multidrug resistance (MDR) is a major obstacle in the successful chemotherapy of ovarian cancer. Inhibition of P-glycoprotein (P-gp), a member of ATP-binding cassette (ABC) transporters, is a well-known strategy to overcome MDR in cancer. The aim of this study was to investigate the efficiency and ability of CRISPR/Cas9 genome editing technology to knockdown ABCB1 gene expression in adriamycin resistant (A2780/ADR) ovarian cancer cell line and evaluate the sensitivity changes to doxorubicin...
February 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29455935/engineering-pgpmos-through-gene-editing-and-systems-biology-a-solution-for-phytoremediation
#7
REVIEW
Supratim Basu, Roel C Rabara, Sangeeta Negi, Pratyoosh Shukla
In light of extensive urbanization and deforestation, toxic wastes are being released into the atmosphere, causing increased air and soil pollution. Conventional methods of soil remediation are time consuming and labor and cost intensive, rendering them uneconomical to maintain sustainable agriculture. One solution is to use natural resources like plants and microbes for phytoremediation. A thorough systemic knowledge of plant-microbe interactions will allow the use of gene editing and gene manipulation techniques to increase the efficiency of plants in phytoremediation...
February 15, 2018: Trends in Biotechnology
https://www.readbyqxmd.com/read/29455686/cost-utility-analysis-of-private-contracting-to-reduce-public-waiting-times-for-joint-replacement-surgery
#8
Jonathan Karnon, Bahareh Mesgarian Haghighi, Babu Sajjad, Sokunthea Yem, Anuji Gamage, Aaron Thorpe
OBJECTIVES: Earlier treatment of publicly funded patients may achieve health gains that justify the additional costs of reducing waiting times. This study reports on the cost-effectiveness of implementing a private contracting model to meet alternative maximum waiting time targets for publicly funded patients undergoing total knee replacement surgery in Australia. METHODS: A linked decision tree and cohort Markov model was developed and populated and validated using secondary data sources to represent the pathways, costs, and quality adjusted life-years (QALYs) gained of non-urgent patients with alternative waiting times for total knee replacement surgery to a maximum age of 100 years...
February 19, 2018: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29455472/double-digest-rad-sequencing-outperforms-microsatellite-loci-at-assigning-paternity-and-estimating-relatedness-a-proof-of-concept-in-a-highly-promiscuous-bird
#9
Derrick J Thrasher, Bronwyn G Butcher, Leonardo Campagna, Michael S Webster, Irby J Lovette
Information on genetic relationships among individuals is essential to many studies of the behavior and ecology of wild organisms. Parentage and relatedness assays based on large numbers of SNP loci hold substantial advantages over the microsatellite markers traditionally used for these purposes. We present a double-digest restriction site-associated DNA sequencing (ddRAD-seq) analysis pipeline that, as such, simultaneously achieves the SNP discovery and genotyping steps and which is optimized to return a statistically powerful set of SNP markers (typically 150-600 after stringent filtering) from large numbers of individuals (up to 240 per run)...
February 17, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29455188/laboratory-hemostasis-from-biology-to-the-bench
#10
Giuseppe Lippi, Emmanuel J Favaloro
Physiological hemostasis is an intricate biological system, where procoagulant and anticoagulant forces interplay and preserves blood fluidity when blood vessels are intact, or trigger clot formation to prevent excessive bleeding when blood vessels are injured. The modern model of hemostasis is divided into two principal phases. The first, defined as primary hemostasis, involves the platelet-vessel interplay, whilst the second, defined as secondary hemostasis, mainly involves coagulation factors, damaged cells and platelet surfaces, where the so-called coagulation cascade rapidly develops...
February 19, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29454824/candida-albicans-biology-molecular-characterization-pathogenicity-and-advances-in-diagnosis-and-control-an-update
#11
REVIEW
Maryam Dadar, Ruchi Tiwari, Kumaragurubaran Karthik, Sandip Chakraborty, Youcef Shahali, Kuldeep Dhama
Candida albicans is an emerging multidrug-resistant fungal pathogen representing an important source of invasive disease in humans and generating high healthcare costs worldwide. This fungus is frequently found in different anatomical sites of healthy persons and could induce systemic and superficial infections under optimal environmental conditions. Invasive candidiasis (IC) is an important nosocomial infection with high morbidity and mortality rates in hospitalized children. It represents a major source of prolonged infections in intensive care unit (ICU), particularly in immunosuppressed or elderly patients...
February 15, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29454799/identification-of-genomic-variants-causing-sperm-abnormalities-and-reduced-male-fertility
#12
REVIEW
Jeremy F Taylor, Robert D Schnabel, Peter Sutovsky
Whole genome sequencing has identified millions of bovine genetic variants; however, there is currently little understanding about which variants affect male fertility. It is imperative that we begin to link detrimental genetic variants to sperm phenotypes via the analysis of semen samples and measurement of fertility for bulls with alternate genotypes. Artificial insemination (AI) bulls provide a useful model system because of extensive fertility records, measured as sire conception rates (SCR). Genetic variants with moderate to large effects on fertility can be identified by sequencing the genomes of fertile and subfertile or infertile sires identified with high or low SCR as adult AI bulls or yearling bulls that failed Breeding Soundness Evaluation...
February 10, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29454738/-satellite-center-of-human-milk-analysis-of-cost-reduction
#13
L Affumicato, T Sánchez Tamayo, M G Espinosa Fernandez, M Peña Caballero, C E Ruiz Morcillo, R Acebes Tosti, E Salguero García
INTRODUCTION: Donor milk is the second best alternative for a newborn after the mother's own milk, especially when the baby is a premature or a sick child since this milk has the advantage of protecting against necrotizing enterocolitis. There are currently 13 milk banks in Spain, however this is not sufficient to supply all Spanish neonatal units with donor milk. In order to bring donor milk to the babies in Neonatal Unit of the Regional University Hospital of Malaga, a Satellite Centre (CS) was created in 2012, depending on the Milk Bank of Virgen de las Nieves Hospital in Granada...
February 14, 2018: Revista de Calidad Asistencial: Organo de la Sociedad Española de Calidad Asistencial
https://www.readbyqxmd.com/read/29454300/gold-copper-bimetallic-nanoparticles-supported-on-nano-p-zeolite-modified-carbon-paste-electrode-as-an-efficient-electrocatalyst-and-sensitive-sensor-for-determination-of-hydrazine
#14
Fatemeh Amiripour, Seyed Naser Azizi, Shahram Ghasemi
In this report, a facile, efficient and low cost electrochemical sensor based on bimetallic Au-Cu nanoparticles supported on P nanozeolite modified carbon paste electrode (Au-Cu/NPZ/CPE) was constructed and its efficiency for determination of hydrazine in trace level was studied. For this purpose, agro waste material, stem sweep ash (SSA) was employed as the starting material (silica source) for the synthesis of nano P zeolite (NPZ). After characterization of the synthesized NPZ by analytical instruments (scanning electronic microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and Fourier transform infrared (FT-IR) spectroscopy), construction of Au-Cu/NPZ/CPE was performed by three steps procedure involving preparation of nano P zeolite modified carbon paste electrode (NPZ/CPE), introducing Cu +2 ions into nano zeolite structure by ion exchange and electrochemical reduction of Cu +2 ions upon applying constant potential...
February 5, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29454276/use-of-mixed-wastewaters-from-piggery-and-winery-for-nutrient-removal-and-lipid-production-by-chlorella-sp-mm3
#15
Vimalkumar Ganeshkumar, Suresh R Subashchandrabose, Rajarathnam Dharmarajan, Kadiyala Venkateswarlu, Ravi Naidu, Mallavarapu Megharaj
The larger-scale generation of piggery and winery wastewaters and consequent eutrophication are quite alarming, necessitating the use of a cost-effective treatment. This study attempted to remediate wastewaters from piggery and winery mixed in the ratios of 20:80, 50:50, 80:20, 100:0 and 0:100, in terms of nutrient removal and subsequent lipid accumulation by soil microalga, Chlorella sp. MM3. The per cent removal of total nitrogen and phosphates by the alga from mixed wastewaters within 10-days ranged between 51 and 89 and 26-49, respectively...
February 6, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29454246/screening-of-physicochemical-treatment-processes-for-reducing-toxicity-of-hair-care-products-wastewaters
#16
Elisa Dias de Melo, Ann Mounteer, Eduarda Reis, Ellen Costa, Alana Vilete
Toxicity reduction in wastewaters from small hair care products manufacturing companies using coagulation/flocculation/sedimentation or flotation, membrane separation and powdered activated charcoal adsorption was evaluated. Raw wastewater composition varied widely within and especially between companies, but all exhibited high acute toxicity to Daphnia similis (EC(I)50; 48 h < 0.02-0.33%). Coagulation with aluminum sulfate and polyaluminum chloride aided by cationic or anionic polymers, as well as filtration on ultra (UF) and nanofiltration (NF) membranes efficiently removed turbidity (>99%) and oil and grease (>99%) and all treated samples exhibited similar dissolved organic matter contents...
February 14, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29454059/towards-a-regulatory-use-of-alternative-developmental-neurotoxicity-testing-dnt
#17
Andrea Terron, Susanne Hougaard Bennekou
There is a need for a more effective Developmental Neurotoxicity (DNT) screening which is scientifically driven by the fact that the developing nervous system might be more sensitive to exposures to some hazardous chemical. Additional concern comes from the recent societal concerns that toxic chemicals can contribute to the prevalence of neurodevelopment disabilities. Consequently, hazard identification and actions to reduce exposure to these chemicals is a priority in chemical risk assessment. To reach this goal a cost-efficient testing strategy based on a reliable in-vitro testing battery should be developed...
February 14, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29453765/statistical-assessment-of-dna-extraction-methodology-for-culture-independent-analysis-of-microbial-community-associated-with-diverse-environmental-samples
#18
Rishi Mahajan, Sampan Attri, Kavita Sharma, Niharika Singh, Deepika Sharma, Gunjan Goel
Cost-effectiveness, quality, time-effectiveness and ease of the methodology are the most crucial factors in isolating quality DNA from wide variety of samples. Thus, research efforts focusing on the development of an efficient DNA extraction protocol is the need of the hour. The present study therefore, focuses on development of an efficient, rapid and free of inhibitory substances based methodology for extracting metagenomic DNA from diverse environmental samples viz. anaerobic biogas digesta, ruminant stomach, human feces, soil, and microbial starter cultures used for preparation of fermented food...
February 16, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/29453721/fenton-treatment-of-bio-treated-fermentation-based-pharmaceutical-wastewater-removal-and-conversion-of-organic-pollutants-as-well-as-estimation-of-operational-costs
#19
Yunqin Cheng, Yunlu Chen, Juncheng Lu, Jianxin Nie, Yan Liu
The Fenton process is used as a tertiary treatment to remove organic pollutants from the effluent of bio-treated pharmaceutical wastewater (EBPW). The optimal and most appropriate Fenton conditions were determined by an orthogonal array test and single-factor experiments. The removal of chemical oxygen demand (COD) was influenced by the following factors in a descending order: H 2 O 2 /Fe(II) molar ratio > H 2 O 2 dosage > reaction time. Under the most appropriate Fenton conditions (H 2 O 2 /Fe(II) molar ratio of 1:1, H 2 O 2 dosage of 120 mg L -1 and reaction time of 10 min), the COD and dissolved organic carbon (DOC) were removed with efficiencies of 62 and 53%, respectively, which met the national discharge standard (GB 21903-2008) for the Lake Tai Basin, China...
February 16, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29453693/exploiting-the-unique-phenotypes-of-the-earthworm-eudrilus-eugeniae-to-evaluate-the-toxicity-of-chemical-substances
#20
Beryl Vedha Yesudhason, Paulkumar Kanniah, Elaiya Raja Subramanian, Vasanthakumar Ponesakki, Veeraragavan Rajendiran, Sudhakar Sivasubramaniam
Both the evaluation and the determination of toxicity of chemical substances present in the environment have implications in human health. In this present study, the natural phenomenon named autotomy, a self-defense mechanism employed by several animals against the toxic chemical contaminants, was considered to assess the toxicity of different chemical substances. We investigated the effects of glucose, sodium chloride, kanamycin, mercuric chloride, arsenic trioxide, and lead oxide on the phenotypes of earthworm Eudrilus eugeniae...
February 16, 2018: Environmental Monitoring and Assessment
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