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Clinical microbiology

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https://www.readbyqxmd.com/read/29453860/fungal-infections-in-patients-with-inflammatory-bowel-disease-a-systematic-review
#1
REVIEW
George A Stamatiades, Petros Ioannou, George Petrikkos, Constantinos Tsioutis
BACKGROUND: Despite reports of fungal infections in patients with inflammatory bowel disease (IBD), their clinical and microbiological characteristics remain unknown. OBJECTIVES: The aim of this systematic review is to examine all available evidence regarding fungal infections in patients with IBD. METHODS: Systematic search of PubMed (through 27 May 2017) for studies providing data on clinical, microbiological, treatment and outcome data of fungal infections in patients with IBD...
February 17, 2018: Mycoses
https://www.readbyqxmd.com/read/29451055/early-discontinuation-of-empirical-antibacterial-therapy-in-febrile-neutropenia-the-antibiostop-study
#2
Lenaïg Le Clech, Jean-Philippe Talarmin, Marie-Anne Couturier, Jean-Christophe Ianotto, Christophe Nicol, Ronan Le Calloch, Stéphanie Dos Santos, Pascal Hutin, Didier Tandé, Virginie Cogulet, Christian Berthou, Gaëlle Guillerm
INTRODUCTION: Immediate empirical antibiotic therapy is mandatory in febrile chemotherapy-induced neutropenia, but its optimal duration is unclear, especially in patients with fever of unknown origin (FUO). OBJECTIVES: The primary objective of this 20-month prospective observational study was to evaluate the feasibility and safety of short-term antibiotic treatment in afebrile or febrile patients exhibiting FUO, irrespective of their neutrophil count. The secondary objective was to describe the epidemiology of all episodes of febrile neutropenia...
February 16, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29448846/are-infectious-diseases-and-microbiology-new-fields-for-thermal-therapy-research
#3
Deniz Gazel, Mehmet Yılmaz
Antimicrobial chemotherapy and surgery are classical methods for treating infectious diseases. However, there is a need for alternative methods to cure infections caused by antibiotic-resistant pathogens, recurrent or chronic infections, and unreachable local infections in which the use of drugs or surgery is anatomically and physically restricted. Several microorganisms are known to be sensitive to mild hyperthermia, and this sensitivity is one of the potential benefits proposed for the host during an episode of fever...
February 15, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29447900/microbiology-and-antibiotic-therapy-of-subperiosteal-orbital-abscess-in-children-with-acute-ethmoiditis
#4
A Coudert, S Ayari-Khalfallah, P Suy, E Truy
OBJECTIVE: The objective of this study was to investigate the microbiological cultures and the management of acute ethmoiditis complicated by subperiosteal orbital abscess (SPOA) in a pediatric population. METHODS: The medical records of children under 18 years old was performed in a tertiary referral pediatric center from January 2009 to April 2017. Clinical examination, computed tomography scans, medical and surgical treatments were reviewed and compared to other studies in literature...
March 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29447029/nanosilver-and-the-microbiological-activity-of-the-particulate-solids-versus-the-leached-soluble-silver
#5
Merisa B Faiz, Rose Amal, Christopher P Marquis, Elizabeth J Harry, Georgios A Sotiriou, Scott A Rice, Cindy Gunawan
Nanosilver (Ag NPs) is currently one of the most commercialized antimicrobial nanoparticles with as yet, still unresolved cytotoxicity origins. To date, research efforts have mostly described the antimicrobial contribution from the leaching of soluble silver, while the undissolved solid Ag particulates are often considered as being microbiologically inert, serving only as source of the cytotoxic Ag ions. Here, we show the rapid stimulation of lethal cellular oxidative stress in bacteria by the presence of the undissolved Ag particulates...
February 15, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29447024/microbiology-and-clinical-outcomes-of-puerperal-sepsis-a-prospective-cohort-study
#6
Rumbidzai Majangara, Muchabayiwa Francis Gidiri, Zvavahera Mike Chirenje
The objectives of this study were to determine the identity and antibacterial susceptibility profiles of bacteria colonising the female genital tract and blood stream and their association with clinical outcomes in women with puerperal sepsis. A prospective descriptive cohort study was conducted at two tertiary hospitals in Zimbabwe. Endocervical swabs and blood were collected for culture and susceptibility testing from 151 consecutive women who met the World Health Organisation criteria for puerperal sepsis...
February 15, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29446860/development-of-a-clinical-prediction-rule-for-tuberculous-meningitis-in-adults-in-lima-peru
#7
Lely Solari, Alonso Soto, Patrick van der Stuyft
OBJECTIVES: Diagnosis of Tuberculous Meningitis (TM) is a challenge in countries with a high burden of the disease and constrained resources and Clinical Prediction Rules (CPRs) could be of assistance. We aimed at developing a CPR for diagnosis of TM in a Latin American setting with high tuberculosis incidence and a concentrated HIV epidemic. METHODS: We enrolled adult patients with clinical suspicion of TM attending two hospitals in Lima, Peru. We obtained information on potential anamnestic, clinical and laboratory predictive findings that are easy to collect and promptly available...
February 15, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29446650/methods-for-culturing-anaerobes-from-human-specimen
#8
Elodie Guilhot, Saber Khelaifia, Bernard La Scola, Didier Raoult, Grégory Dubourg
Anaerobes represent the dominating population in the human gut microbiota and play a key role in gut homeostasis. In addition, several anaerobes are now considered as probiotics and they remain essential to several processes in the field of biotechnology. With the implementation of MALDI-TOF MS in routine laboratories, anaerobes are no longer neglected in clinical microbiology, as their identification is made easy. However, the isolation and identification of anaerobic bacteria, remains time consuming, fastidious and costly...
February 15, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29445617/pathogenic-leptospira-advances-in-understanding-the-molecular-pathogenesis-and-virulence
#9
REVIEW
Ciamak Ghazaei
Leptospirosis is a common zoonotic disease has emerged as a major public health problem, with developing countries bearing disproportionate burdens. Although the diverse range of clinical manifestations of the leptospirosis in humans is widely documented, the mechanisms through which the pathogen causes disease remain undetermined. In addition, leptospirosis is a much-neglected life-threatening disease although it is one of the most important zoonoses occurring in a diverse range of epidemiological distribution...
2018: Open Veterinary Journal
https://www.readbyqxmd.com/read/29444761/chronic-infection-sustained-by-a-pseudomonas-aeruginosa-high-risk-clone-producing-the-vim-1-metallo-%C3%AE-lactamase-in-a-cystic-fibrosis-patient-after-lung-transplantation
#10
Simona Pollini, Claudia Mugnaioli, Daniela Dolce, Silvia Campana, Anna Silvia Neri, Giovanni Taccetti, Gian Maria Rossolini
BACKGROUND: The significance of chronic lung infection by multidrug-resistant (MDR) pathogens in Cystic Fibrosis (CF) transplanted patients remains controversial, and the available information is overall limited. Here we describe the case of a chronic infection, sustained by a metallo-β-lactamase (MBL)-producing P. aeruginosa strain, in a CF patient following lung transplantation. METHODS: Twelve P. aeruginosa isolates collected from a CF patient over a 15-years follow-up period after lung transplantation were analysed for their antibiotic susceptibility profile, MBL production and clonal relatedness...
February 12, 2018: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29444749/microbiological-diagnosis-of-adult-tuberculous-meningitis-in-a-ten-year-cohort-in-indonesia
#11
Lidya Chaidir, Jessi Annisa, Sofiati Dian, Ida Parwati, Arlisa Alisjahbana, Feby Purnama, Adri van der Zanden, Ahmad Rizal Ganiem, Reinout van Crevel
We evaluated microbiological diagnosis of tuberculous (TB) meningitis in a referral hospital in Indonesia. Over a ten-year period, we examined cerebrospinal fluid (CSF) samples of 1180 adult meningitis suspects. Sensitivity of different methods was compared, and results were stratified for HIV status, disease severity, and CSF volume. TB meningitis was bacteriologically confirmed in 501 patients. Using clinical diagnosis as reference standard (n = 713), sensitivity of different methods was 12.2% (86/703) for microscopy, 42% (73/174) for Xpert MTB/RIF, 46...
January 9, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29443394/catheter-related-bloodstream-infections-in-adults-receiving-home-parenteral-nutrition-substantial-differences-in-incidence-comparing-a-strict-microbiological-to-a-clinically-based-diagnosis
#12
Siri Tribler, Christopher F Brandt, Mark Hvistendahl, Michael Staun, Per Brøbech, Claus E Moser, Palle B Jeppesen
BACKGROUND: A common complication in patients receiving home parenteral nutrition (HPN) is catheter-related bloodstream infections (CRBSIs). The CRBSI incidence has been advocated as an outcome parameter assessing the quality of care. This study aimed to illustrate how the use of different CRBSI definitions affects the reported incidence. MATERIALS AND METHODS: In an observational study based on the Copenhagen intestinal failure database, all clinically reported CRBSIs from 2002-2013 were compared with data from the affiliated microbiological database according to recommended CRBSI criteria...
February 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29442084/comparative-evaluation-of-antiplaque-and-antigingivitis-effects-of-an-herbal-and-chlorine-dioxide-mouthwashes-a-clinicomicrobiological-study
#13
Srinivasa T Siddeshappa, Shruti Bhatnagar, Ramreddy K Yeltiwar, Humera Parvez, Asmita Singh, Saket Banchhor
Aim: The aim of the present study was to compare the efficacy of herbal mouthwash and chlorine dioxide mouthwash in reduction of plaque and gingivitis. Settings and Design: In a randomized clinical trial, forty patients were randomly selected and divided equally into two groups. Materials and Methods: After professional oral prophylaxis, the clinical parameters plaque index, gingival index, and modified sulcular bleeding index were recorded at baseline, 7 th day, 14 th day, and 21 st day...
January 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29440788/effectiveness-of-erythrosine-mediated-photodynamic-antimicrobial-chemotherapy-on-dental-plaque-aerobic-microorganisms-a-randomized-controlled-trial
#14
Manohar Bhat, Swathi Acharya, Kakarla Veera Venkata Prasad, Raghavendra Kulkarni, Anithraj Bhat, Devikripa Bhat
Background: Dental plaque is one of the predominant causes of major oral diseases. Although mechanical and chemical methods are extensively followed to control the development of plaque, plaque-related diseases still persist. Therefore, this necessitates for alternative measures of plaque control, one such alternative is photodynamic antimicrobial chemotherapy (PACT). Materials and Methods: Split mouth randomized clinical trial (CTRI/2017/03/008239) was conducted on 30 participants who reported to the hospital...
May 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29437495/incidence-of-endophthalmitis-after-intravitreal-injections-risk-factors-microbiology-profile-and-clinical-outcomes
#15
Chitaranjan Mishra, Prajna Lalitha, Gunasekaran Rameshkumar, Rupesh Agrawal, Praveen Kumar Balne, Mani Iswarya, Naresh Babu Kannan, Kim Ramasamy
PURPOSE: To report the incidence and characteristics of endophthalmitis after intravitreal injections (IVI) of antivascular endothelial growth factor agents and triamcinolone acetonide. METHODS: Patients' medical records were retrospectively reviewed from January 2009 to June 2016, and the incidence, risk factors, clinical and microbiological characteristics of post-IVI endophthalmitis were evaluated. RESULTS: The total number of intravitreal injections given, which included ranibizumab, bevacizumab, and triamcinolone acetonide, was 20,566, of which 27 cases developed endophthalmitis, giving an overall incidence of 0...
February 13, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29433835/towards-automated-detection-semi-quantification-and-identification-of-microbial-growth-in-clinical-bacteriology-a-proof-of-concept
#16
Antony Croxatto, Raphaël Marcelpoil, Cédrick Orny, Didier Morel, Guy Prod'hom, Gilbert Greub
BACKGROUND: Automation in microbiology laboratories impacts management, workflow, productivity and quality. Further improvements will be driven by the development of intelligent image analysis allowing automated detection of microbial growth, release of sterile samples, identification and quantification of bacterial colonies and reading of AST disk diffusion assays. We investigated the potential benefit of intelligent imaging analysis by developing algorithms allowing automated detection, semi-quantification and identification of bacterial colonies...
December 2017: Biomedical Journal
https://www.readbyqxmd.com/read/29433799/international-survey-among-orthopaedic-trauma-surgeons-lack-of-a-definition-of-fracture-related-infection
#17
M Morgenstern, T F Moriarty, R Kuehl, R G Richards, M A McNally, M H J Verhofstad, O Borens, C Zalavras, M Raschke, S L Kates, W J Metsemakers
INTRODUCTION: Fracture-related infection (FRI) is one of the most challenging musculoskeletal complications in orthopaedic-trauma surgery. Although the orthopaedic community has developed and adopted a consensus definition of prosthetic joint infections (PJI), it still remains unclear how the trauma surgery community defines FRI in daily clinical practice or in performing clinical research studies. The central aim of this study was to survey the opinions of a global network of trauma surgeons on the definitions and criteria they routinely use, and their opinion on the need for a unified definition of FRI...
February 6, 2018: Injury
https://www.readbyqxmd.com/read/29432657/clinical-profile-antibiotic-susceptibility-pattern-of-bacterial-isolates-and-factors-associated-with-complications-in-culture-proven-typhoid-patients-admitted-to-an-urban-hospital-in-bangladesh
#18
Halima Khatun, Shoeb Bin Islam, Nurun Nahar Naila, Syed Aminul Islam, Baitun Nahar, Md Nur Haque Alam, Tahmeed Ahmed
OBJECTIVES: Typhoid fever is one of the major causes of morbidity and mortality in typhoid endemic countries like Bangladesh. However, data on the clinical and microbiological profile as well as factors associated with complications of typhoid in Bangladesh are scarce. We intended to characterize the clinical and microbiological profile of culture-proven typhoid fever and to identify factors associated with complications. METHODOLOGY: Retrospective analysis of clinical data from 431 patients with culture-confirmed typhoid fever admitted to Dhaka hospital of International Centre for Diarrhoeal Disease Research, Bangladesh, between January 2010 and December 2014...
February 12, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29432640/diamond-burs-versus-curettes-in-root-planing-a-randomized-clinical-trial
#19
Fatma Türktekin, Nurcan Buduneli, David F Lappin, Tuğba Türk, Eralp Buduneli
AIM: This study compares diamond burs and curettes by clinical, microbiological, biochemical, scanning electron microscopic parameters and treatment time data in the non-surgical periodontal treatment of patients with chronic periodontitis. METHODS: Two quadrants of each of the 12 patients received root planing with diamond burs whereas other 2 quadrants were treated with curettes. Clinical periodontal measurements were recorded at baseline and then 1, 3, 6 months after completion of non-surgical periodontal treatment...
February 12, 2018: Australian Dental Journal
https://www.readbyqxmd.com/read/29430190/salmonella-enterica-serovars-typhimurium-and-enteritidis-causing-mixed-infections-in-febrile-children-in-mozambique
#20
Vanesa García, Inácio Mandomando, Joaquim Ruiz, Silvia Herrera-León, Pedro L Alonso, M Rosario Rodicio
Background and purpose: Invasive nontyphoidal salmonellosis, mostly caused by serovars Typhimurium and Enteritidis of Salmonella enterica, has emerged as a major public health problem in sub-Saharan Africa. The aim of this study was the clinical and microbiological characterization of nontyphoidal salmonellosis episodes affecting febrile children in Mozambique. Patients and methods: The clinical records of the patients were evaluated, and S. enterica isolates were characterized with regard to serovar, phage type, antimicrobial resistance (phenotype/responsible genes), plasmid content, pulsed-field gel electrophoresis, and multilocus sequence typing...
2018: Infection and Drug Resistance
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