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Quantitative imaging

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https://www.readbyqxmd.com/read/29458234/ultrasonographic-anatomy-of-reproductive-female-leopard-geckos-eublepharis-macularius
#1
Ophélie Cojean, Claire Vergneau-Grosset, Isabelle Masseau
Captive leopard geckos (Eublepharis macularius) often present to the exotic clinic for gastrointestinal impactions, follicular stasis, or dystocia. To our knowledge, normal ultrasonographic anatomy of these lizards has not been described. The objectives of this prospective, anatomic, analytical study were to develop ultrasound techniques for this species and to describe the normal sonographic anatomy of the head, coelomic cavity, and tail. Eleven, healthy, female leopard geckos were included. A linear array 13-18 MHz transducer was used...
February 19, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29458122/regional-variations-of-cortical-bone-in-the-humeral-head-region-a-preliminary-study
#2
Yeming Wang, Jian Li, Jianhua Yang, Jingming Dong
BACKGROUND: Incidence of proximal humeral fractures dramatically increased over the last decade due to demographic changes. The goal of this study was to analyze regional characteristics of cortical bone in the humeral head region using cortical bone mapping (CBM) technique. METHODS: The proximal humerus of 103 healthy volunteers was imaged by clinical computed tomography (CT) scans. Three groups of volunteers were identified according to age: group A (20-39 years), group B (40-59 years), and group C (>60 years)...
February 16, 2018: Bone
https://www.readbyqxmd.com/read/29457791/quantitative-mapping-and-minimization-of-super-resolution-optical-imaging-artifacts
#3
Siân Culley, David Albrecht, Caron Jacobs, Pedro Matos Pereira, Christophe Leterrier, Jason Mercer, Ricardo Henriques
Super-resolution microscopy depends on steps that can contribute to the formation of image artifacts, leading to misinterpretation of biological information. We present NanoJ-SQUIRREL, an ImageJ-based analytical approach that provides quantitative assessment of super-resolution image quality. By comparing diffraction-limited images and super-resolution equivalents of the same acquisition volume, this approach generates a quantitative map of super-resolution defects and can guide researchers in optimizing imaging parameters...
February 19, 2018: Nature Methods
https://www.readbyqxmd.com/read/29457319/the-impact-of-b-1-correction-on-mp2rage-cortical-t-1-and-apparent-cortical-thickness-at-7t
#4
Roy A M Haast, Dimo Ivanov, Kâmil Uludağ
Determination of cortical thickness using MRI has often been criticized due to the presence of various error sources. Specifically, anatomical MRI relying on T1 contrast may be unreliable due to spatially variable image contrast between gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF). Especially at ultra-high field (≥ 7T) MRI, transmit and receive B1 -related image inhomogeneities can hamper correct classification of tissue types. In the current paper, we demonstrate that residual B1+ (transmit) inhomogeneities in the T1 -weighted and quantitative T1 images using the MP2RAGE sequence at 7T lead to biases in cortical thickness measurements...
February 18, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29457299/t1%C3%AF-mapping-of-articular-cartilage-grafts-after-autologous-osteochondral-transplantation-for-osteochondral-lesions-of-the-talus-a-longitudinal-evaluation
#5
Naoki Haraguchi, Koki Ota, Naoki Nishida, Takuma Ozeki, Takashige Yoshida, Atsushi Tsutaya
BACKGROUND: Clinical results of autologous osteochondral transplantation (AOT) for treatment of osteochondral lesions of the talus have been mixed. T1ρ imaging can be used to noninvasively detect early cartilage degeneration. PURPOSE OR HYPOTHESIS: To quantitatively assess, by means of T1ρ imaging, changes over time in the biochemical health of grafted cartilage after AOT for osteochondral lesions of the talus. STUDY TYPE: Retrosepctive case series...
February 19, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29456878/non-destructive-two-photon-excited-fluorescence-imaging-identifies-early-nodules-in-calcific-aortic-valve-disease
#6
Lauren M Baugh, Zhiyi Liu, Kyle P Quinn, Sam Osseiran, Conor L Evans, Gordon S Huggins, Philip W Hinds, Lauren D Black, Irene Georgakoudi
Calcifications occur during the development of healthy bone, and at the onset of calcific aortic-valve disease (CAVD) and many other pathologies. Although the mechanisms regulating early calcium deposition are not fully understood, they may provide targets for new treatments and for early interventions. Here, we show that two-photon excited fluorescence (TPEF) can provide quantitative and sensitive readouts of calcific nodule formation, in particular in the context of CAVD. Specifically, by means of the decomposition of TPEF spectral images from excised human CAVD valves and from rat bone prior to and following demineralization, as well as from calcific nodules formed within engineered gels, we identified an endogenous fluorophore that correlates with the level of mineralization in the samples...
November 2017: Nature Biomedical Engineering
https://www.readbyqxmd.com/read/29455281/sensitive-colorimetric-assay-for-uric-acid-and-glucose-detection-based-on-multilayer-modified-paper-with-smartphone-as-signal-readout
#7
Xu Wang, Fang Li, Ziqi Cai, Kaifan Liu, Jing Li, Boyang Zhang, Jianbo He
In this work, a multilayer-modified paper-based colorimetric sensing platform with improved color uniformity and intensity was developed for the sensitive and selective determination of uric acid and glucose with smartphone as signal readout. In detail, chitosan, different kinds of chromogenic reagents, and horseradish peroxidase (HRP) combined with a specific oxidase, e.g., uricase or glucose oxidase (GOD), were immoblized onto the paper substrate to form a multilayer-modified test paper. Hydrogen peroxide produced by the oxidases (uricase or GOD) reacts with the substrates (uric acid or glucose), and could oxidize the co-immoblized chromogenic reagents to form colored products with HRP as catalyst...
February 17, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29455067/gap-enhanced-raman-tags-for-high-contrast-sentinel-lymph-node-imaging
#8
Zhouzhou Bao, Yuqing Zhang, Ziyang Tan, Xia Yin, Wen Di, Jian Ye
The sentinel lymph node (SLN) biopsy is gaining in popularity as a procedure to investigate the lymphatic metastasis of malignant tumors. The commonly used techniques to identify the SLNs in clinical practice are blue dyes-guided visualization, radioisotope-based detection and near-infrared fluorescence imaging. However, all these methods have not been found to perfectly fit the clinical criteria with issues such as short retention time in SLN, poor spatial resolution, autofluorescence, low photostability and high cost...
February 10, 2018: Biomaterials
https://www.readbyqxmd.com/read/29454770/molecular-imaging-of-apoptosis-in-ischemia-reperfusion-injury-with-radiolabeled-duramycin-targeting-phosphatidylethanolamine-effective-target-uptake-and-reduced-nontarget-organ-radiation-burden
#9
Hideki Kawai, Farhan Chaudhry, Aditya Shekhar, Artiom Petrov, Takehiro Nakahara, Takashi Tanimoto, Dongbin Kim, Jiqiu Chen, Djamel Lebeche, Francis G Blankenberg, Koon Y Pak, Frank D Kolodgie, Renu Virmani, Partho Sengupta, Navneet Narula, Roger J Hajjar, Harry W Strauss, Jagat Narula
OBJECTIVES: The purpose of this study was to evaluate the feasibility of imaging apoptosis in experimental ischemia-reperfusion model by technetium-99m (99m Tc)-labeled Duramycin, and compare it to an established tracer,99m Tc-labeled Annexin-V, which has a relative disadvantage of high radiation burden to nontarget organs. BACKGROUND: During apoptosis, the cell membrane phospholipids-phosphatidylserine (PS) and phosphatidylethanolamine (PE) are exposed and can be targeted by Annexin-V and Duramycin, respectively, for in vivo imaging...
February 9, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29454767/diagnostic-performance-of-fully-automated-pixel-wise-quantitative-myocardial-perfusion-imaging-by-cardiovascular-magnetic-resonance
#10
Li-Yueh Hsu, Matthew Jacobs, Mitchel Benovoy, Allison D Ta, Hannah M Conn, Susanne Winkler, Anders M Greve, Marcus Y Chen, Sujata M Shanbhag, W Patricia Bandettini, Andrew E Arai
OBJECTIVES: The authors developed a fully automated framework to quantify myocardial blood flow (MBF) from contrast-enhanced cardiac magnetic resonance (CMR) perfusion imaging and evaluated its diagnostic performance in patients. BACKGROUND: Fully quantitative CMR perfusion pixel maps were previously validated with microsphere MBF measurements and showed potential in clinical applications, but the methods required laborious manual processes and were excessively time-consuming...
February 9, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29454098/quantitative-imaging-features-and-postoperative-hepatic-insufficiency-a-multi-institutional-expanded-cohort
#11
Linda M Pak, Jayasree Chakraborty, Mithat Gonen, William C Chapman, Richard Kg Do, Bas Groot Koerkamp, Kees Verhoef, Ser Yee Lee, Marco Massani, Eric P van der Stok, Amber L Simpson
BACKGROUND: Post-hepatectomy liver insufficiency (PHLI) is a significant cause of morbidity and mortality after liver resection. Quantitative imaging analysis using CT scans measures variations in pixel intensity related to perfusion. A preliminary study demonstrated a correlation between quantitative imaging features of the future liver remnant (FLR) parenchyma from preoperative CT scans and PHLI. The objective of the present study was to explore the potential application of quantitative imaging analysis in PHLI in an expanded, multi-institutional cohort...
February 14, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29454006/predicting-cognitive-decline-with-deep-learning-of-brain-metabolism-and-amyloid-imaging
#12
Hongyoon Choi, Kyong Hwan Jin
For effective treatment of Alzheimer's disease (AD), it is important to identify subjects who are most likely to exhibit rapid cognitive decline. We aimed to develop an automatic image interpretation system based on a deep convolutional neural network (CNN) which can accurately predict future cognitive decline in mild cognitive impairment (MCI) patients using flurodeoxyglucose and florbetapir positron emission tomography (PET). PET images of 139 patients with AD, 171 patients with MCI and 182 normal subjects obtained from Alzheimer's Disease Neuroimaging Initiative database were used...
February 14, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29453592/patient-specific-registration-of-3d-ct-angiography-cta-with-x-ray-fluoroscopy-for-image-fusion-during-transcatheter-aortic-valve-implantation-tavi-increases-performance-of-the-procedure
#13
I Vernikouskaya, W Rottbauer, J Seeger, B Gonska, V Rasche, Jochen Wöhrle
OBJECTIVES: The aim of this study was to adapt patient-specifically a co-registration procedure for image fusion (IF) of a pre-interventional CT dataset with real-time X-ray (XR) fluoroscopy during transfemoral transcatheter aortic valve implantation (TAVI), enabling improved performance of the procedure. BACKGROUND: The ability to use 3D models of the respective anatomies to complement the anatomic information obtained by XR fluoroscopy and provide a greater degree of real-time anatomical guidance holds great potential for complex cardiac interventions, especially for TAVI procedures with cerebral protection...
February 16, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29452984/quantitative-cerebrovascular-pathology-in-a-community-based-cohort-of-older-adults
#14
Swati Rane, Natalie Koh, Peter Boord, Tara Madhyastha, Mary K Askren, Suman Jayadev, Brenna Cholerton, Eric Larson, Thomas J Grabowski
Cerebrovascular disease, especially small vessel pathology, is the leading comorbidity in degenerative disorders. We applied arterial spin labeling and cerebrovascular reserve (CVR) imaging to quantify small vessel disease and study its effect on cognitive symptoms in nondemented older adults from a community-based cohort. We evaluated baseline cerebral blood flow (CBF) using arterial spin labeling and percent signal change as a marker of CVR using blood-oxygen level-dependent imaging following a breath-hold stimulus...
January 31, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29452619/monitoring-response-to-therapy
#15
REVIEW
Mike M Sathekge, Alfred O Ankrah, Ismaheel Lawal, Mariza Vorster
Monitoring response to treatment is a key element in the management of infectious diseases, yet controversies still persist on reliable biomarkers for noninvasive response evaluation. Considering the limitations of invasiveness of most diagnostic procedures and the issue of expression heterogeneity of pathology, molecular imaging is better able to assay in vivo biologic processes noninvasively and quantitatively. The usefulness of 18 F-FDG-PET/CT in assessing treatment response in infectious diseases is more promising than for conventional imaging...
March 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29451788/a-systematic-evaluation-of-the-use-of-human-plasma-and-serum-for-mass-spectrometry-based-shotgun-proteomics
#16
Jiayi Lan, Antonio Núñez Galindo, James Doecke, Christopher Fowler, Ralph N Martins, Stephanie R Rainey-Smith, Ornella Cominetti, Loïc Dayon
Over the last two decades, EDTA-plasma has been used as the preferred sample matrix for human blood proteomic profiling. Serum has also been employed widely. Only a few studies have assessed the difference and relevance of the proteome profiles obtained from plasma samples, such as EDTA-plasma or lithium-heparin-plasma, and serum. A more complete evaluation of the use of EDTA-plasma, heparin-plasma, and serum would greatly expand the comprehensiveness of shotgun proteomics of blood samples. In this study, we evaluated the use of heparin-plasma with respect to EDTA-plasma and serum to profile blood proteomes using a scalable automated proteomic pipeline (ASAP2)...
February 16, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29451775/fluorescence-imaging-of-huntingtin-mrna-knockdown
#17
Eunseon Oh, Yuhong Liu, Mahesh V Sonar, Diane Merry, Eric Wickstrom
Huntington's disease (HD) is an autosomal-dominant neurodegenerative genetic disorder caused by CAG repeat expansion in exon 1 of the HTT gene. Expression of the mutant gene results in the production of a neurotoxic polyglutamine (polyQ)-expanded huntingtin (Htt) protein. Clinical trials of knockdown therapy of mutant polyglutamine-encoding HTT mRNA in Huntington's disease (HD) have begun. To measure HTT mRNA knockdown effectiveness in human cells, we utilized a fluorescent hybridization imaging agent specific to the region encompassing the human HTT mRNA initiation codon...
February 16, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29451726/single-organelle-dynamics-linked-to-3d-structure-by-correlative-live-cell-3d-electron-microscopy
#18
Job Fermie, Nalan Liv, Corlinda Ten Brink, Elly G van Donselaar, Wally H Müller, Nicole L Schieber, Yannick Schwab, Hans C Gerritsen, Judith Klumperman
Live-cell correlative light-electron microscopy (live-cell-CLEM) integrates live movies with the corresponding EM image, but a major challenge is to relate the dynamic characteristics of single organelles to their 3D ultrastructure. Here we introduce focused ion beam scanning electron microscopy (FIB-SEM) in a modular live-cell CLEM pipeline for single organelle CLEM. We transfected cells with LAMP-1-GFP, analyzed the dynamics of individual GFP-positive spots, and correlated these to their corresponding fine-architecture and immediate cellular environment...
February 16, 2018: Traffic
https://www.readbyqxmd.com/read/29451329/high-spatiotemporal-resolution-bssfp-imaging-of-hyperpolarized-1-13-c-pyruvate-and-1-13-c-lactate-with-spectral-suppression-of-alanine-and-pyruvate-hydrate
#19
Eugene Milshteyn, Cornelius von Morze, Jeremy W Gordon, Zihan Zhu, Peder E Z Larson, Daniel B Vigneron
PURPOSE: The balanced steady-state free precession (bSSFP) acquisition enables high spatiotemporal resolution for hyperpolarized 13 C MRI at 3T but is limited by spectral contamination from adjacent resonances. The purpose of this study was to develop a framework for in vivo dynamic high resolution imaging of hyperpolarized [1- 13 C]pyruvate and [1- 13 C]lactate generated in vivo at 3T by simplifying the spectrum through the use of selective suppression pulses. METHODS: Spectral suppression pulses were incorporated into the bSSFP sequence for suppression of [1- 13 C]alanine and [1- 13 C]pyruvate-hydrate signals, leaving only the pyruvate and lactate resonances...
February 16, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29451130/intrinsic-optical-signal-imaging-of-the-blood-volume-changes-is-sufficient-for-mapping-the-resting-state-functional-connectivity-in-the-rodent-cortex
#20
Sreekanth Kura, Hongyu Xie, Buyin Fu, Cenk Ayata, David A Boas, Sava Sakadzic
OBJECTIVE: Resting state functional connectivity (RSFC) allows the study of functional organization in normal and diseased brain by measuring the spontaneous brain activity generated under resting conditions. Intrinsic optical signal imaging (IOSI) based on multiple illumination wavelengths has been used successfully to compute RSFC maps in animal studies. The IOSI setup complexity would be greatly reduced if only a single wavelength can be used to obtain comparable RSFC maps. APPROACH: We used anesthetized mice and performed various comparisons between the RSFC maps based on single wavelength as well as oxy-, deoxy- and total hemoglobin concentration changes...
February 16, 2018: Journal of Neural Engineering
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