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Quantitative imaging

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https://www.readbyqxmd.com/read/29236342/longitudinal-assessment-of-rabbit-renal-fibrosis-induced-by-unilateral-ureteral-obstruction-using-two-dimensional-susceptibility-weighted-imaging
#1
Jing-Gang Zhang, Zhao-Yu Xing, Ting-Ting Zha, Xiao-Juan Tian, Ya-Nan Du, Jie Chen, Wei Xing
BACKGROUND: Previous studies indicated that two-dimensional-susceptibility weighted imaging (2D-SWI) could serve as a useful biomarker for differentiating the grade of liver fibrosis. PURPOSE: To evaluate the feasibility of 2D-SWI in the dynamic quantification of renal fibrosis in a rabbit model. STUDY TYPE: Longitudinal study. ANIMAL MODEL: Twenty-Four New Zealand White Rabbits including control group (n = 4); and renal fibrosis group (n = 20), by means of a unilateral ureteral obstruction (UUO) model...
December 13, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29236297/mri-change-metrics-of-facioscapulohumeral-muscular-dystrophy-stir-and-t1
#2
Mark R Ferguson, Sandra L Poliachik, Christopher B Budech, Nancy E Gove, Gregory T Carter, Leo H Wang, Daniel G Miller, Dennis W W Shaw, Seth D Friedman
INTRODUCTION: MRI evaluation in facioscapulohumeral muscular dystrophy (FSHD) demonstrates fatty replacement and inflammation/edema in muscle. Our previous work demonstrated Short T1 Inversion Recovery (STIR)-hyperintense (STIR+) signal in muscle 2 years prior to fatty replacement. We evaluated leg muscle STIR changes and fatty replacement within 14 months. METHODS: FSHD subjects received 2 MRI scans of thigh and calf over a 6.9-13.8 month interval. Quality of life measures were collected...
December 13, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29235271/wide-field-of-view-common-path-lateral-shearing-digital-holographic-interference-microscope
#3
Priyanka Vora, Vismay Trivedi, Swapnil Mahajan, Nimit Patel, Mugdha Joglekar, Vani Chhaniwal, Ali-Reza Moradi, Bahram Javidi, Arun Anand
Quantitative three-dimensional (3-D) imaging of living cells provides important information about the cell morphology and its time variation. Off-axis, digital holographic interference microscopy is an ideal tool for 3-D imaging, parameter extraction, and classification of living cells. Two-beam digital holographic microscopes, which are usually employed, provide high-quality 3-D images of micro-objects, albeit with lower temporal stability. Common-path digital holographic geometries, in which the reference beam is derived from the object beam, provide higher temporal stability along with high-quality 3-D images...
December 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29234914/discriminating-mgmt-promoter-methylation-status-in-patients-with-glioblastoma-employing-amide-proton-transfer-weighted-mri-metrics
#4
Shanshan Jiang, Qihong Rui, Yu Wang, Hye-Young Heo, Tianyu Zou, Hao Yu, Yi Zhang, Xianlong Wang, Yongxing Du, Xinrui Wen, Fangyao Chen, Jihong Wang, Charles G Eberhart, Jinyuan Zhou, Zhibo Wen
OBJECTIVES: To explore the feasibility of using amide proton transfer-weighted (APTw) MRI metrics as surrogate biomarkers to identify the O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status in glioblastoma (GBM). METHODS: Eighteen newly diagnosed GBM patients, who were previously scanned at 3T and had a confirmed MGMT methylation status, were retrospectively analysed. For each case, a histogram analysis in the tumour mass was performed to evaluate several quantitative APTw MRI metrics...
December 12, 2017: European Radiology
https://www.readbyqxmd.com/read/29234913/prediction-of-the-histopathologic-findings-of-intrahepatic-cholangiocarcinoma-qualitative-and-quantitative-assessment-of-diffusion-weighted-imaging
#5
Sara Lewis, Cecilia Besa, Mathilde Wagner, Kartik Jhaveri, Shingo Kihira, Hongfa Zhu, Nima Sadoughi, Sandra Fischer, Amogh Srivastava, Eric Yee, Koenraad Mortele, James Babb, Swan Thung, Bachir Taouli
OBJECTIVE: To correlate qualitative and quantitative diffusion weighted imaging (DWI) characteristics of intrahepatic cholangiocarcinoma (ICC) with histopathologic tumour grade and fibrosis content. METHODS: Fifty-one patients (21M/30F; mean age 61y) with ICC and MRI including DWI were included in this IRB-approved multicentre retrospective study. Qualitative tumour features were assessed. Tumour apparent diffusion coefficient (ADC) mean, minimum, and normalized (nADCliver) values were computed...
December 12, 2017: European Radiology
https://www.readbyqxmd.com/read/29234459/a-structure-design-method-for-reduction-of-mri-acoustic-noise
#6
Jiaofen Nan, Nannan Zong, Qiqiang Chen, Liangliang Zhang, Qian Zheng, Yongquan Xia
The acoustic problem of the split gradient coil is one challenge in a Magnetic Resonance Imaging and Linear Accelerator (MRI-LINAC) system. In this paper, we aimed to develop a scheme to reduce the acoustic noise of the split gradient coil. First, a split gradient assembly with an asymmetric configuration was designed to avoid vibration in same resonant modes for the two assembly cylinders. Next, the outer ends of the split main magnet were constructed using horn structures, which can distribute the acoustic field away from patient region...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/29234137/ratiometric-mass-spectrometry-for-cell-identification-and-quantitation-using-intracellular-dual-biomarkers
#7
Xiaoming Chen, Fangjie Wo, Jiang Chen, Jie Tan, Tao Wang, Xiao Liang, Jianmin Wu
This study proposed an easy-to-use method for cell identification and quantitation by ratiometric matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Two pairs of MS peaks in the molecular fingerprint of cells were selected as intracellular dual-biomarkers due to the stability and specificity of their ratio values in different types of hepatocellular cancer (HCC) cell lines. Five types of HCC cells can be thereafter differentiated based on these two pairs of intracellular peptides/proteins...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29234043/multipulse-sodium-magnetic-resonance-imaging-for-multicompartment-quantification-proof-of-concept
#8
Alina Gilles, Armin M Nagel, Guillaume Madelin
We present a feasibility study of sodium quantification in a multicompartment model of the brain using sodium (23Na) magnetic resonance imaging. The proposed method is based on a multipulse sequence acquisition and simulation at 7 T, which allows to differentiate the 23Na signals emanating from three compartments in human brain in vivo: intracellular (compartment 1), extracellular (compartment 2), and cerebrospinal fluid (compartment 3). The intracellular sodium concentration C 1 and the volume fractions α 1, α 2, and α 3 of all respective three brain compartments can be estimated...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29234002/dual-energy-micro-ct-for-quantifying-the-time-course-and-staining-characteristics-of-ex-vivo-animal-organs-treated-with-iodine-and-gadolinium-based-contrast-agents
#9
Juliana Martins de Souza E Silva, Julian Utsch, Melanie A Kimm, Sebastian Allner, Michael F Epple, Klaus Achterhold, Franz Pfeiffer
Chemical staining of soft-tissues can be used as a strategy to increase their low inherent contrast in X-ray absorption micro-computed tomography (micro-CT), allowing to obtain fast three-dimensional structural information of animal organs. Though some staining agents are commonly used in this context, little is known about the staining agents' ability to stain specific types of tissues; the times necessary to provide a sufficient contrast; and the effect of staining solution in distorting the tissue. Here we contribute to studies of animal organs (mouse heart and lungs) using staining combined with dual-energy micro-CT (DECT)...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233836/radiomic-features-are-superior-to-conventional-quantitative-computed-tomographic-metrics-to-identify-coronary-plaques-with-napkin-ring-sign
#10
Márton Kolossváry, Júlia Karády, Bálint Szilveszter, Pieter Kitslaar, Udo Hoffmann, Béla Merkely, Pál Maurovich-Horvat
BACKGROUND: Napkin-ring sign (NRS) is an independent prognostic imaging marker of major adverse cardiac events. However, identification of NRS is challenging because of its qualitative nature. Radiomics is the process of extracting thousands of quantitative parameters from medical images to create big-data data sets that can identify distinct patterns in radiological images. Therefore, we sought to determine whether radiomic analysis improves the identification of NRS plaques. METHODS AND RESULTS: From 2674 patients referred to coronary computed tomographic angiography caused by stable chest pain, expert readers identified 30 patients with NRS plaques and matched these with 30 non-NRS plaques with similar degree of calcification, luminal obstruction, localization, and imaging parameters...
December 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29233823/large-cardiac-muscle-patches-engineered-from-human-induced-pluripotent-stem-cell-derived-cardiac-cells-improve-recovery-from-myocardial-infarction-in-swine
#11
Ling Gao, Zachery R Gregorich, Wuqiang Zhu, Saidulu Mattapally, Yasin Oduk, Xi Lou, Ramaswamy Kannappan, Anton V Borovjagin, Gregory P Walcott, Andrew E Pollard, Vladimir G Fast, Xinyang Hu, Steven G Lloyd, Ying Ge, Jianyi Zhang
Background -Here, we generated human cardiac muscle patches (hCMPs) of clinically relevant dimensions (4 cm × 2 cm × 1.25 mm) by suspending cardiomyocytes, smooth-muscle cells, and endothelial cells that had been differentiated from human induced-pluripotent stem cells (hiPSCs) in a fibrin scaffold and then culturing the construct on a dynamic (rocking) platform. Methods -In vitro assessments of hCMPs suggest maturation in response to dynamic culture stimulation. In vivo assessments were conducted in a porcine model of myocardial infarction (MI)...
December 12, 2017: Circulation
https://www.readbyqxmd.com/read/29233668/expression-of-hmgb1-in-maternal-exposure-to-fine-particulate-air-pollution-induces-lung-injury-in-rat-offspring-assessed-with-micro-ct
#12
Wenting Tang, Suran Huang, Lili Du, Wen Sun, Zhiqiang Yu, Yanmei Zhou, Jingsi Chen, Xiuying Li, Xiaomei Li, Bolan Yu, Dunjin Chen
OBJECTIVES: Maternal particulate matter with less than 2.5 μm in diameter (PM2.5) is associated with an increased risk for acute lower respiratory infections and allergic airway inflammation; however, its effect on the developing lung remains unclear. The aim of this study is to determine the effect of maternal PM2.5 during pregnancy on lung development in offspring. METHODS: Timed pregnant Sprague-Dawley rats were treated with PM2.5 (0.1, 0.5, 2.5, or 7.5 mg/kg) once every 3 days from day 0-18 of pregnancy and delivered at term...
December 9, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29233632/rationale-and-design-of-the-worldwide-prospective-multicenter-registry-on-radiation-dose-estimates-of-cardiac-ct-angiography-in-daily-practice-in-2017-protection-vi
#13
Thomas J Stocker, Simon Deseive, Marcus Chen, Jonathon Leipsic, Martin Hadamitzky, Ronen Rubinshtein, Erik L Grove, Xiang-Ming Fang, John Lesser, Pál Maurovich-Horvat, Hugo Marques, Daniele Andreini, Ramzi Tabbalat, Joon-Won Kang, Joachim Eckert, Patricia Dickson, Signe H Forsdahl, Jess Lambrechtsen, Roberto C Cury, Jörg Hausleiter
BACKGROUND: Cardiac computed tomography angiography (cardiac CTA) is an increasingly used versatile imaging method to evaluate coronary and cardiac morphology. Owing to improvements in technology, image quality has continuously improved over the last 10-20 years. At the same time, numerous non-randomized and randomized studies have been performed to reduce the associated radiation exposure. Currently, it is unclear if the advances in technology and knowledge about radiation reduction translated into reduced levels of cardiac CTA radiation dose in daily clinical practice as well as a wide utilization of dose-saving strategies...
December 5, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29233600/noise-reduction-in-flair2-images-using-total-generalized-variation-gaussian-and-wiener-filtering
#14
René Schranzer, Alexander Rauscher, Evelin Haimburger, Kristian Bredies, Gernot Reishofer, Günther Grabner
PURPOSE: Multiplication of FLAIR and T2-weighted MRI scans results in images (called FLAIR2) with an improved contrast-to-noise ratio (CNR) for multiple sclerosis (MS) lesions but with a reduced signal-to-noise ratio (SNR). Denoising of these images may therefore further improve FLAIR2 image quality. The purpose of this work is to present a systematic investigation of FLAIR2 image denoising methods using Gaussian, Wiener and Total Generalized Variation (TGV) filtering approaches. MATERIALS AND METHODS: T2-weighted and FLAIR data of four MS patients were used...
December 9, 2017: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/29233163/intra-articular-injection-of-expanded-autologous-bone-marrow-mesenchymal-cells-in-moderate-and-severe-knee-osteoarthritis-is-safe-a-phase-i-ii-study
#15
Mahasen Al-Najar, Hiba Khalil, Jihad Al-Ajlouni, Eman Al-Antary, Mohammad Hamdan, Reem Rahmeh, Dana Alhattab, Osama Samara, Mohamad Yasin, Amenah Al Abdullah, Esraa Al-Jabbari, Dima Hmaid, Hanan Jafar, Abdalla Awidi
BACKGROUND: Knee osteoarthritis (KOA) is a major health problem especially in the aging population. There is a need for safe treatment that restores the cartilage and reduces the symptoms. The use of stem cells is emerging as a possible option for the moderate and severe cases. This study aimed at testing the safety of autologous bone marrow mesenchymal stem cells (BM-MSCs) expanded in vitro when given intra-articularly to patients with stage II and III KOA. As a secondary end point, the study tested the ability of these cells to relieve symptoms and restore the knee cartilage in these patients as judged by normalized knee injury and Osteoarthritis Outcome Score (KOOS) and by magnetic resonance imaging (MRI)...
December 12, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29232698/low-energy-extracorporeal-shockwave-therapy-eswt-improves-metaphyseal-fracture-healing-in-an-osteoporotic-rat-model
#16
Gina A Mackert, Matthias Schulte, Christoph Hirche, Dimitra Kotsougiani, Julian Vogelpohl, Bernd Hoener, Teresa Fiebig, Stefanie Kirschner, Marc A Brockmann, Marcus Lehnhardt, Ulrich Kneser, Leila Harhaus
PURPOSE: As result of the current demographic changes, osteoporosis and osteoporotic fractures are becoming an increasing social and economic burden. In this experimental study, extracorporeal shock wave therapy (ESWT), was evaluated as a treatment option for the improvement of osteoporotic fracture healing. METHODS: A well-established fracture model in the metaphyseal tibia in the osteoporotic rat was used. 132 animals were divided into 11 groups, with 12 animals each, consisting of one sham-operated group and 10 ovariectomized (osteoporotic) groups, of which 9 received ESWT treatment...
2017: PloS One
https://www.readbyqxmd.com/read/29232649/multi-hypothesis-tracking-of-the-tongue-surface-in-ultrasound-video-recordings-of-normal-and-impaired-speech
#17
Catherine Laporte, Lucie Ménard
Characterizing tongue shape and motion, as they appear in real-time ultrasound (US) images, is of interest to the study of healthy and impaired speech production. Quantitative anlaysis of tongue shape and motion requires that the tongue surface be extracted in each frame of US speech recordings. While the literature proposes several automated methods for this purpose, these either require large or very well matched training sets, or lack robustness in the presence of rapid tongue motion. This paper presents a new robust method for tongue tracking in US images that combines simple tongue shape and motion models derived from a small training data set with a highly flexible active contour (snake) representation and maintains multiple possible hypotheses as to the correct tongue contour via a particle filtering algorithm...
December 5, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/29232571/investigating-the-excited-state-optical-properties-and-origin-of-large-stokes-shift-in-benz-c-d-indole-n-heteroarene-bf2-dyes-with-ab-initio-tools
#18
Yogesh Gawale, Nagaiyan Sekar
Density Functional Theory and Time Dependent Density Functional Theory computations reveal experimental trends accurately and provide an insight into the origin of red shifted optical spectra, large Stokes shift, nonlinear optical responses and quantitative description of the singlet-triplet energy gap of recently synthesized highly fluorescent membrane permeable benz[c,d]indole N-heteroarene BF2 rigidified BBN and BBC dyes. Our results benchmark the importance of the DFT functionals and polarization functions using the accurate basis set for the calculations of excitation energies, band gaps, dipole moment, non-linear optical properties and geometrical parameters...
December 7, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29232142/janus-iron-oxides-semiconducting-polymer-nanoparticle-tracer-for-cell-tracking-by-magnetic-particle-imaging
#19
Guosheng Song, Min Chen, Yanrong Zhang, Liyang Cui, Haibo Qu, Xianchuang Zheng, Max Wintermark, Zhuang Liu, Jianghong Rao
Iron oxides nanoparticles tailored for magnetic particle imaging (MPI) have been synthesized, and their MPI signal intensity is 3 times of commercial MPI contrast (Ferucarbotran, also called Vivotrax) and 7 times of MRI contrast (Feraheme) at the same Fe concentration. MPI tailored iron oxide nanoparticles were encapsulated with semiconducting polymers to produce Janus nanoparticles that possessed optical and magnetic properties for MPI and fluorescence imaging. Janus particles were applied to cancer cell labeling and in vivo tracking, and as few as 250 cells were imaged by MPI after implantation, corresponding to an amount of 7...
December 12, 2017: Nano Letters
https://www.readbyqxmd.com/read/29232024/myocardial-perfusion-reserve-index-in-children-with-kawasaki-disease
#20
Richard M Friesen, Michal Schäfer, Pei-Ni Jone, Nana Appiawiah, Daniel Vargas, Brian Fonseca, Michael V DiMaria, Uyen Truong, LaDonna Malone, Lorna P Browne
BACKGROUND: Coronary artery lesions in patients with Kawasaki disease (KD) can impair myocardial perfusion, yet evaluation of perfusion defects by cardiac magnetic resonance (MR) in children is often qualitative. PURPOSE: In this study we aimed to use a quantitative method of myocardial perfusion using stress cardiac MR-derived myocardial perfusion reserve index (MPRI) in children with KD and compare MPRI with ventricular mechanical performance evaluated by cardiac MR strain analysis...
December 12, 2017: Journal of Magnetic Resonance Imaging: JMRI
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