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JOURNAL ARTICLE
Maximilian Mordig, Gunnar Rätsch, André Kahles
MOTIVATION: The Oxford Nanopore Technologies (ONT) ReadUntil API enables selective sequencing, which aims to selectively favor interesting over uninteresting reads, e.g., to deplete or enrich certain genomic regions. The performance gain depends on the selective sequencing decision-making algorithm (SSDA) which decides whether to reject a read, stop receiving a read, or wait for more data. Since real runs are time-consuming and costly, simulating the ONT sequencer with support for the ReadUntil API is highly beneficial for comparing and optimizing new SSDAs...
April 11, 2024: Bioinformatics
#2
JOURNAL ARTICLE
Gamze Ersan, Mohamed S Gaber, François Perreault, Sergi Garcia-Segura
Electro-regeneration is emerging as a new technique to regenerate spent carbon adsorbents through an electrochemical process. In this study, sequential adsorption and electro-regeneration of ciprofloxacin (CIP)-laden carbon were investigated using both pristine and iron (Fe)-doped F400 activated carbon in distilled, deionized (DI) water and reverse osmosis (RO) concentrate water. The impact of reactor flow rate and sequential adsorption/electro-regeneration cycles on the regeneration efficiency were also evaluated...
March 26, 2024: Water Research
#3
JOURNAL ARTICLE
Vanessa Muñoz-Gutierrez, Fabián A Cornejo, Katja Schmidt, Christian K Frese, Manuel Halte, Marc Erhardt, Alexander K W Elsholz, Kürşad Turgay, Emmanuelle Charpentier
Initiation of bacterial DNA replication takes place at the origin of replication ( oriC ), a region characterized by the presence of multiple DnaA boxes that serve as the binding sites for the master initiator protein DnaA. This process is tightly controlled by modulation of the availability or activity of DnaA and oriC during development or stress conditions. Here, we aimed to uncover the physiological and molecular consequences of stopping replication in the model bacterium Bacillus subtilis . We successfully arrested replication in B...
March 28, 2024: MSystems
#4
JOURNAL ARTICLE
Paul Kessler
Ultrasound (US) technology has significantly expanded the spectrum of regional anesthesiological procedures in recent years. Abdominal wall blocks are becoming an increasingly integral part of a multimodal postoperative pain concept after abdominal surgery, gynecological or urological interventions. Thoracic epidural analgesia remains the gold standard for extensive surgery. The requirement for rapid postoperative mobilization and discharge after lower extremity surgery has led to the abandonment of neuroaxial or plexus blocks in favor of selective, peripheral blocks such as the PENG block or adductor canal block...
March 2024: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
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JOURNAL ARTICLE
Marcílio Rodrigues Pinto, Kirlya Isabel da Silva Medeiros, Letícia Menezes Maia, Antonio Alexandre Coelho, Ana Paula Negreiros Nunes Alves, Caio Ferreira Freire Caetano, Karine Cestaro Mesquita, Paulo Goberlânio de Barros Silva, Fabricio Bitu Sousa
OBJECTIVE: To evaluate the role of induced nitric oxide synthase (iNOS) in nociception/orofacial discomfort in rats submitted to tooth whitening with hydrogen peroxide (H₂O₂). DESIGN: Wistar rats were divided into three groups (n = 24/group): a sham group not submitted to whitening treatment, a saline group submitted to whitening treatment, and a test group submitted to whitening treatment and blockade of iNOS with aminoguanidine 50 mg/kg/day...
May 2024: Archives of Oral Biology
#6
Tara Tritsch, Mohammadali M Shoja, Andrew Schleffer, R Shane Tubbs
The anterior communicating artery (ACoA) plays a pivotal role in maintaining cerebral hemodynamics, as its diameter is a major determinant of blood collateralization through the circle of Willis following internal carotid artery occlusion. While variations of this artery are not uncommon, data on their clinicopathologic relevance are limited. In this report, we present our observation from a fresh cadaver of a male individual who had succumbed to cardiac causes. The circle of Willis displayed a duplicated ACoA with atherosclerosis that predominantly affected the posterior horn while sparing the anterior horn...
January 2024: Curēus
#7
JOURNAL ARTICLE
Omar Buksh, Anfar Jar, Ahmad Khogeer, Hani Alzahrani, Rabea Akram, Mohammad Taher, Mahmoud Al Akra'a, Adel Alammari, Islam Junaid
OBJECTIVES: Double J (DJ) stent is widely used in cases of ureteric strictures as a temporary solution; however, it has certain limitations, such as the need for frequent exchange. Alternatively, a long-lasting thermoexpandable stent (Memokath™ 051) has been used to relieve ureteral obstructions in comorbid patients with multiple reported advantages, such as longer durability which avoids the need of frequent exchanges. In addition, it can be used in certain cases of urethral strictures...
2024: Urology Annals
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JOURNAL ARTICLE
Michele Petrella, Anna Maria Borruto, Lorenzo Curti, Domi, Esi Domi, Li Xu, Estelle Barbier, Alice Ilari, Markus Heilig, Friedbert Weiss, Guido Mannaioni, Alessio Masi, Roberto Ciccocioppo
The Nociceptin/Orphanin FQ (N/OFQ) peptide and its receptor NOP are highly expressed within several regions of the mesolimbic system, including the ventral tegmental area (VTA). Evidence indicates that the N/OFQ-NOP receptor system is involved in reward processing and historically it has been proposed that activation of NOP receptors attenuates the motivation for substances of abuse. However, recent findings demonstrated that drug self-administration and relapse to drug-seeking are also attenuated after administration of NOP receptor antagonists...
February 14, 2024: Neuropharmacology
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JOURNAL ARTICLE
Bara Levit, Paul F Funk, Yael Hanein
The human body's vascular system is a finely regulated network: Blood vessels can change in shape (i.e. constrict, or dilate), their elastic response may shift and they may undergo temporary and partial blockages due to pressure applied by skeletal muscles in their immediate vicinity. Simultaneous measurement
of muscle activation and the corresponding changes in vessel diameter, in particular in regions such as the face, is challenging, and the manner by which muscle activation constricts blood vessels has been experimentally largely overlooked...
February 13, 2024: Biomedical Physics & Engineering Express
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JOURNAL ARTICLE
Tanzina Mollick, Suhas Darekar, Basile Dalarun, Flavia Plastino, Juan Zhang, Andres Pastor Fernández, Twana Alkasalias, Helder André, Sonia Laín
Retinoblastoma is an eye cancer that commonly affects young children. Despite significant advances, current treatments cause side effects even when administered locally, and patients may still have to undergo enucleation. This is particularly disheartening in cases of bilateral retinoblastoma. Hence, there is an urgent need for novel therapeutic strategies. Inhibitors of the enzyme dihydroorotate dehydrogenase (DHODH), which is involved in the de novo pyrimidine ribonucleotide synthesis pathway, have proven to be effective in preclinical trials against several cancers including pediatric cancers...
January 15, 2024: Heliyon
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JOURNAL ARTICLE
Saeid Vakilian, Sulaiman Al-Hashmi, Juhaina Al-Kindi, Fahad Al-Fahdi, Nasar Al-Wahaibi, Asem Shalaby, Hamad Al-Riyami, Ahmed Al-Harrasi, Fatemeh Jamshidi-Adegani
Post-operative adhesion can cause complications, such as pain, and organ blockage, in the abdominal regions. To address this issue, surgical techniques, and anti-adhesive treatments have been applied. Given the significant role of vascularization in adhesion band formation, Avastin (Ava) that targets VEGF can be applied to prevent peritoneal adhesion bands. Moreover, Alginate (Alg), a natural polysaccharide, is a promising physical barrier to prevent adhesion bands. Incorporating Ava into Alg hydrogel in a form of 3D-printed scaffold (Alg/Ava) has potential to suppress inflammation and angiogenesis, leading to reduce peritoneal adhesion bands...
February 6, 2024: Macromolecular Bioscience
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JOURNAL ARTICLE
Cemal Cingi, Nuray Bayar Muluk, İbrahim Çukurova, Rıza Dündar, Ustün Osma, Cengiz Bal, Alaattin Zirek, Ali Budak, Ali Seyed Resuli, Asif Selimoğlu, Aslı Elif Tanuğur Samancı, Ayşe Karaoğullarından, Begüm Yılmaz, Bengi Arslan, Bilal Sizer, Celalettin Cihan, Çiğdem Fırat Koca, Deniz Avcı, Doğukan Aydenizöz, Ethem Ünver, Elvin Alaskarov, Emrah Gülmez, Fatih Gündoğan, Gözde Günay, Hasan Çetiner, Hilal Güngör, İsmail Salcan, Mahmut Emre Gündoğan, Makbule Özlem Akbay, Mehmet Akdağ, Mehmet Erkan Kaplama, Mehmet Yaşar, Mehtap Koparal, Murat Kar, Mustafa Altıntaş, Mümtaz Taner Torun, Nazım Bozan, Neslihan Sarı, Nihat Susaman, Nurten Küçük, Osman Erdoğan, Osman Gül, Özlem Sancaklı, Pınar Kundi, Rezzan Okyay Budak, Sait Karaman, Soner Taşar, Songül Demir, Şeyda Belli, Tarık Yağcı, Taylan Bilici, Turgut Çelik, Yavuz Sultan Selim Yıldırım, Ali Timucin Atayoglu, Reşat Kubilay Irkan, Duygu Zorlu, Demet Can
Objectives: This study aimed to evaluate how Rhinapi nasal spray affects symptoms of allergic rhinitis. Methods: In this prospective, multicenter, observational study, 10,000 patients (comprising 5028 males and 4972 females) exhibiting symptoms of allergic rhinitis (namely, nasal discharge, sneezing, nasal itching, and nasal obstruction) from different centers in different regions of Turkey were enrolled in the study between March 2022 and March 2023. All the patients wanted to participate in the study and were administered Rhinapi one puff to each nostril three times a day, for a period of 3 weeks...
January 29, 2024: Ear, Nose, & Throat Journal
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JOURNAL ARTICLE
Marina Petrova, Sergey Margasyuk, Margarita Vorobeva, Dmitry Skvortsov, Olga A Dontsova, Dmitri D Pervouchine
The mammalian BRD2 and BRD3 genes encode structurally related proteins from the bromodomain and extraterminal domain protein family. The expression of BRD2 is regulated by unproductive splicing upon inclusion of exon 3b, which is located in the region encoding a bromodomain. Bioinformatic analysis indicated that BRD2 exon 3b inclusion is controlled by a pair of conserved complementary regions (PCCR) located in the flanking introns. Furthermore, we identified a highly conserved element encoding a cryptic poison exon 5b and a previously unknown PCCR in the intron between exons 5 and 6 of BRD3 , however, outside of the homologous bromodomain...
March 2024: NAR genomics and bioinformatics
#14
JOURNAL ARTICLE
Xiaolin Ye, Ningxin Xiong, Shaopei Huang, Qixing Wu, Hongning Chen, Xuelong Zhou
Tin-based hybrid flow batteries have demonstrated dendrite-free morphology and superior performance in terms of cycle life and energy density. However, the quick accumulation of electrodeposits near the electrode/membrane interface blocks the ion transport pathway during the charging of the battery, resulting to a very limited areal capacity (especially at high current density) that significantly hinders its deployment in long-duration storage applications. Herein, a conductivity-activity dual-gradient design is disclosed by electrically passivating the carbon felt near the membrane/electrode interface and chemically activating the carbon felt near the electrode/current collector interface...
January 9, 2024: Small Methods
#15
Liyi Chen, Zhengdao Deng, Boateng Asamoah, Myles Mc Laughlin
UNLABELLED: Transcranial direct current stimulation (tDCS) is a noninvasive neuromodulation method that can modulate many brain functions including learning and memory. Recent evidence suggests that tDCS memory effects may be caused by co-stimulation of scalp nerves such as the trigeminal nerve (TN), and not the electric field in the brain. The TN gives input to brainstem nuclei, including the locus coeruleus that controls noradrenaline release across brain regions, including hippocampus...
December 13, 2023: bioRxiv
#16
JOURNAL ARTICLE
Yangyang Tang, Cong Tao, Zheng Zhang, Song Liu, Fulin Dong, Duohuai Zhang, Jinchang Zhang, Xiaoling Wang
Understanding the mechanism of biofilm distribution and detachment is very important to effectively improve water treatment and prevent blockage in porous media. The existing research is more related to the local biofilm evolving around one or few microposts and the lack of the integral biofilm evolution in a micropost array for a longer growth period. This study combines microfluidic experiments and mathematical simulations to study the distribution and detachment of biofilm in porous media. Microfluidic chips with an array of microposts with different sizes are designed to simulate the physical pore structure of soil...
December 2023: Water Science and Technology: a Journal of the International Association on Water Pollution Research
#17
JOURNAL ARTICLE
Abdulsalam Aleid, Rahaf Alghareeb, Eyad Omar, Ayman S Almukhlifi, Abdulmohsen Mohammad, Ali A Alqarni, Yazid Binobaiad, Abbas Al Mutair, Mohammed Alessa, Loai Albinsaad
Introduction Peripheral Arterial Disease (PAD) is characterized by arterial narrowing or blockage, causing pain and reduced quality of life. Endovascular interventions, like angioplasty and stenting, offer less invasive treatment options with potential benefits. This study, conducted in the Al-Ahsa region of Saudi Arabia from January to August 2023, aims to assess the impact of these interventions on PAD management in Saudi patients. Specifically, we aim to evaluate their effectiveness in improving clinical outcomes, such as symptom relief and quality of life, and their cost-effectiveness in the Saudi healthcare system...
November 2023: Curēus
#18
JOURNAL ARTICLE
Gregory Smutzer, Emilie Lee, Saleh Salimshahshahani, Visha Puwar, Jeane Gama Wilson
Piperine is an alkaloid that is responsible for the pungency of black pepper and long pepper. This hydrophobic compound causes a spicy sensation when it comes in contact with trigeminal neurons of the oral cavity. Piperine has low solubility in water, which presents difficulties in examining the psychophysical properties of this stimulus by standard aqueous chemosensory tests. This report describes approaches that utilize novel edible film formulations for delivering precise amounts of piperine to the human oral cavity...
December 21, 2023: Physiology & Behavior
#19
Raj Kumar Manas, Sujoy Kumar Chatterji
Management of post-electric burn microstomia is a challenging task, especially in children, as it causes difficulty in feeding and airway problems (secondary to nasal airway blockage). The recreated defect is often full thickness and requires full-thickness tissue for reconstruction. The free flap can provide adequate normal tissue for the restoration of functions and aesthesis of the perioral region. However, performing free flaps in children is equally demanding due to small-diameter vessel anastomosis and postoperative monitoring...
December 2023: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
#20
JOURNAL ARTICLE
Marshall W Ritchie, Jennifer F Provencher, Jane E Allison, Matthew J Muzzatti, Heath A MacMillan
Microplastics (MPs; <5 mm) are a growing concern and a poorly understood threat to biota. We used a generalist insect (a cricket; Gryllodes sigillatus) to examine whether individuals would ingest and physically degrade MPs in their food. We fed crickets a range of concentrations (0, 2.5, 5, and 10% w/w) of fluorescent polyethylene MPs mixed into a standard diet and dissected the gut regions to isolate the MPs within. Comparing plastic content and fragment size within gut regions, we sought to identify whether and where crickets can fragment ingested MP particles...
December 15, 2023: Environmental Pollution
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