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https://www.readbyqxmd.com/read/28292886/optical-probing-of-gastrocnemius-in-patients-with-peripheral-artery-disease-characterizes-myopathic-biochemical-alterations-and-correlates-with-stage-of-disease
#1
Ryan A Becker, Kim Cluff, Nithyanandhi Duraisamy, Hootan Mehraein, Hussam Farhoud, Tracie Collins, George P Casale, Iraklis I Pipinos, Jeyamkondan Subbiah
Peripheral artery disease (PAD) is a condition caused by atherosclerotic blockages in the arteries supplying the lower limbs and is characterized by ischemia of the leg, progressive myopathy, and increased risk of limb loss. The affected leg muscles undergo significant changes of their biochemistry and metabolism including variations in the levels of many key proteins, lipids, and nucleotides. The mechanisms behind these changes are poorly understood. The objective of this study was to correlate the severity of the PAD disease stage and associated hemodynamic limitation (determined by the ankle brachial index, ABI) in the legs of the patients with alterations in the biochemistry of chronically ischemic leg muscle as determined by ATR-Fourier transform infrared micro-spectroscopy...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28212931/uv-protective-poly-lactic-acid-rosin-films-for-sustainable-packaging
#2
Meenu Narayanan, Sravanthi Loganathan, Ravi Babu Valapa, Sabu Thomas, T O Varghese
Recently, biopolymer based plastic materials are regarded as potential alternative for conventional plastics of fossil fuel origin in order to compensate depleting petroleum resources and address environmental pollution issues. Poly(lactic acid) (PLA) is one among the biopolymers which is rapidly commercialized for food packaging application. However, the demerits accompanied with PLA like brittle nature, slower crystallization rate, poor gas barrier and high ultraviolet radiation transmission properties confines its commercial application in food packaging sector...
June 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28191460/assessment-of-influences-of-stenoses-in-right-carotid-artery-on-left-carotid-artery-using-wall-stress-marker
#3
Arindam Bit, Dushali Ghagare, Albert A Rizvanov, Himadri Chattopadhyay
Purpose. Atherosclerosis is a diseased condition of blood vessel. It causes partial blockage in lumen of vessel and affects hemodynamic of localized flowing blood. Complex geometries like region of bifurcation also affects hemodynamic to a larger extent. Complexity further increases in presence of stenoses at region of bifurcation. Such morphological change in vessel largely affects parent as well as corresponding sister and daughter vessels. In this paper, complexity in hemodynamic of blood in pair of carotid arteries (left and right carotid arteries) is evaluated in presence of stenoses at basilar segment of right artery in three-dimensional domain using reconstructed tomographic images of patient...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28102346/human-p53-interacts-with-the-elongating-rnapii-complex-and-is-required-for-the-release-of-actinomycin-d-induced-transcription-blockage
#4
Barbara N Borsos, Ildikó Huliák, Hajnalka Majoros, Zsuzsanna Ujfaludi, Ákos Gyenis, Peter Pukler, Imre M Boros, Tibor Pankotai
The p53 tumour suppressor regulates the transcription initiation of selected genes by binding to specific DNA sequences at their promoters. Here we report a novel role of p53 in transcription elongation in human cells. Our data demonstrate that upon transcription elongation blockage, p53 is associated with genes that have not been reported as its direct targets. p53 could be co-immunoprecipitated with active forms of DNA-directed RNA polymerase II subunit 1 (RPB1), highlighting its association with the elongating RNA polymerase II...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27983906/-b-cell-non-hodgkin-s-lymphoma-with-the-involvement-of-inferior-turbinate-a-case-report
#5
Hasan Çetiner, Erol Keleş, Gülşah Kaygusuz, Yavuz Sultan Selim Yıldırım, Duygu Kankaya
The non-Hodgkin's lymphoma is a significant malignant disease that can involve in the extranodal region of the head and neck. It does not show any specific symptoms when it resides in this region. Swelling, pain and ulceration are important clinical findings. In this article, we report a 57-year-old male patient diagnosed with B cell non-Hodgkin's lymphoma by histopathologic examination, who had nasal blockage, snoring and headache complaints for one year, whose endoscopic nasal examination revealed a mass arising from the right inferior turbinate and the mass was removed surgically by endoscopic approach...
November 2016: Kulak Burun Boğaz Ihtisas Dergisi: KBB, Journal of Ear, Nose, and Throat
https://www.readbyqxmd.com/read/27935059/rna-polymerase-i-dependent-transcription-coupled-nucleotide-excision-repair-of-uv-induced-dna-lesions-at-transcription-termination-sites-in-saccharomyces-cerevisiae
#6
François Peyresaubes, Carlos Zeledon, Laetitia Guintini, Romain Charton, Alexia Muguet, Antonio Conconi
If not repaired, ultraviolet light-induced DNA damage can lead to genome instability. Nucleotide excision repair (NER) of UV photoproducts is generally fast in the coding region of genes, where RNA polymerase-II (RNAP2) arrest at damage sites and trigger transcription-coupled NER (TC-NER). In Saccharomyces cerevisiae, there is RNA polymerase-I (RNAP1)-dependent TC-NER, but this process remains elusive. Therefore, we wished to characterize TC-NER efficiency in different regions of the rDNA locus: where RNAP1 are present at high density and start transcription elongation, where the elongation rate is slow, and in the transcription terminator where RNAP1 pause, accumulate and then are released...
December 9, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27854095/cerebral-venous-sinus-thrombosis-in-a-patient-with-sj%C3%A3-gren-s-syndrome-with-atypical-antibodies-a-case-report
#7
Tsung-Han Ho, Yu-Wei Hsu, Chih-Wei Wang, Jiunn-Tay Lee, Chi-Hsin Ting, Fu-Chi Yang
BACKGROUND: Although Sjögren's syndrome has been known to complicate with white matter lesions, encephalopathy, or stroke, reports of cerebral venous sinus thrombosis due to Sjögren's syndrome with atypical antibodies are rare. CASE REPORT: A 50-year-old woman was admitted to our neurological ward with nausea and vomiting following acute onset of severe headache in the left occipital region. Brain computed tomography revealed no abnormalities. The patient was fully conscious, with normal cognitive functioning, but exhibited unsteady tandem gait...
June 15, 2016: Acta Neurologica Taiwanica
https://www.readbyqxmd.com/read/27847404/neuroprotective-effects-of-bone-marrow-mesenchymal-stem-cells-on-bilateral-common-carotid-arteries-occlusion-model-of-cerebral-ischemia-in-rat
#8
Bagher Pourheydar, Sara Soleimani Asl, Mostafa Azimzadeh, Adel Rezaei Moghadam, Asghar Marzban, Mehdi Mehdizadeh
Cell therapy is the most advanced treatment of the cerebral ischemia, nowadays. Herein, we discuss the neuroprotective effects of bone marrow mesenchymal stem cells (BMSCs) on rat hippocampal cells following intravenous injection of these cells in an ischemia-reperfusion model. Adult male Wistar rats were divided into 5 groups: control, sham (surgery without blockage of common carotid arteries), ischemia (common carotid arteries were blocked for 30 min prior to reperfusion), vehicle (7 days after ischemia PBS was injected via the tail vein), and treatment (injections of BMSC into the tail veins 7 days after ischemia)...
2016: Behavioural Neurology
https://www.readbyqxmd.com/read/27827869/impacts-of-antibiotic-and-bacteriophage-treatments-on-the-gut-symbiont-associated-blissus-insularis-hemiptera-blissidae
#9
Yao Xu, Eileen A Buss, Drion G Boucias
The Southern chinch bug, Blissus insularis, possesses specialized midgut crypts that harbor dense populations of the exocellular symbiont Burkholderia. Oral administration of antibiotics suppressed the gut symbionts in B. insularis and negatively impacted insect host fitness, as reflected by retarded development, smaller body size, and higher susceptibility to an insecticide, bifenthrin. Considering that the antibiotics probably had non-lethal but toxic effects on host fitness, attempts were conducted to reduce gut symbionts using bacteriophage treatment...
November 3, 2016: Insects
https://www.readbyqxmd.com/read/27791148/rna-polymerase-ii-senses-obstruction-in-the-dna-minor-groove-via-a-conserved-sensor-motif
#10
Liang Xu, Wei Wang, Deanna Gotte, Fei Yang, Alissa A Hare, Timothy R Welch, Benjamin C Li, Ji Hyun Shin, Jenny Chong, Jeffrey N Strathern, Peter B Dervan, Dong Wang
RNA polymerase II (pol II) encounters numerous barriers during transcription elongation, including DNA strand breaks, DNA lesions, and nucleosomes. Pyrrole-imidazole (Py-Im) polyamides bind to the minor groove of DNA with programmable sequence specificity and high affinity. Previous studies suggest that Py-Im polyamides can prevent transcription factor binding, as well as interfere with pol II transcription elongation. However, the mechanism of pol II inhibition by Py-Im polyamides is unclear. Here we investigate the mechanism of how these minor-groove binders affect pol II transcription elongation...
November 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27770627/phylogenetic-and-functional-analyses-of-a-plant-protein-related-to-human-b-cell-receptor-associated-proteins
#11
Anastasia K Atabekova, Anna V Pankratenko, Svetlana S Makarova, Ekaterina A Lazareva, Robert A Owens, Andrey G Solovyev, Sergey Y Morozov
Human B-cell receptor-associated protein BAP31 (HsBAP31) is the endoplasmic reticulum-resident protein involved in protein sorting and transport as well as pro-apoptotic signaling. Plant orthologs of HsBAP31 termed 'plant BAP-like proteins' (PBL proteins) have thus far remained unstudied. Recently, the PBL protein from Nicotiana tabacum (NtPBL) was identified as an interactor of Nt-4/1, a plant protein known to interact with plant virus movement proteins and affect the long-distance transport of potato spindle tuber viroid (PSTVd) via the phloem...
January 2017: Biochimie
https://www.readbyqxmd.com/read/27720815/toll-interacting-protein-deficiency-promotes-neurodegeneration-via-impeding-autophagy-completion-in-high-fat-diet-fed-apoe-mouse-model
#12
Keqiang Chen, Ruoxi Yuan, Shuo Geng, Yao Zhang, Taojing Ran, Elizabeth Kowalski, Jingze Liu, Liwu Li
The excessive accumulation of specific cellular proteins or autophagic vacuoles (AVs) within neurons is a pathologic hallmark of neurodegenerative diseases. Constitutive autophagy in neurons prevents abnormal intracellular protein aggregation and is critical for maintaining cell survival. Since our previous study showed that Toll-interacting protein (Tollip)-deficient macrophages had constitutive disruption of endosome-lysosome fusion, we hypothesize that Tollip deficiency may also promote neuron death via blockage of autophagy completion...
January 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27636334/stabilization-of-the-geo2-ge-interface-by-nitrogen-incorporation-in-a-one-step-no-thermal-oxynitridation
#13
Gabriela Copetti, Gabriel V Soares, Cláudio Radtke
The thermal instability of GeO2/Ge structures lasts as a barrier against the development of Ge-based metal-oxide-semiconductor devices. In the present work, stabilization was achieved through the incorporation of nitrogen into the oxide layer by thermally growing GeOxNy films in NO. With this approach, a stable layer is obtained in a single step as opposed to other nitridation techniques (like plasma immersion) which require additional processing. Significant reduction of GeO desorption from the surface and a strong barrier against additional substrate oxidation were obtained by the insertion of a small amount of nitrogen content (N/O ≈ 10%)...
October 12, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27614163/grafting-pnipaam-from-%C3%AE-barrel-shaped-transmembrane-nanopores
#14
Himanshu Charan, Julia Kinzel, Ulrich Glebe, Deepak Anand, Tayebeh Mirzaei Garakani, Leilei Zhu, Marco Bocola, Ulrich Schwaneberg, Alexander Böker
The research on protein-polymer conjugates by grafting from the surface of proteins has gained significant interest in the last decade. While there are many studies with globular proteins, membrane proteins have remained untouched to the best of our knowledge. In this study, we established the conjugate formation with a class of transmembrane proteins and grow polymer chains from the ferric hydroxamate uptake protein component A (FhuA; a β-barrel transmembrane protein of Escherichia coli). As the lysine residues of naturally occurring FhuA are distributed over the whole protein, FhuA was reengineered to have up to 11 lysines, distributed symmetrically in a rim on the membrane exposed side (outside) of the protein channel and exclusively above the hydrophobic region...
November 2016: Biomaterials
https://www.readbyqxmd.com/read/27604741/determination-of-vascular-reactivity-of-middle-cerebral-arteries-from-stroke-and-spinal-cord-injury-animal-models-using-pressure-myography
#15
Mohammad A Anwar, Ali H Eid
Stroke and other neurovascular derangements are main causes of global death. They, along with spinal cord injuries, are responsible for being the principal cause of disability due to neurological and cognitive problems. These problems then lead to a burden on scarce financial resources and societal care facilities as well as have a profound effect on patients' families. The mechanism of action in these debilitating diseases is complex and unclear. An important component of these problems arises from derangement of blood vessels, such as blockage due to clotting/embolism, endothelial dysfunction, and overreactivity to contractile agents, as well as alteration in endothelial permeability...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27599414/minimal-contribution-of-severe-hypertriglyceridemia-in-l-asparaginase-associated-pancreatitis-developed-in-a-child-with-acute-lymphocytic-leukemia
#16
Yoshinori Goto, Ryosei Nishimura, Atsushi Nohara, Shintaro Mase, Toshihiro Fujiki, Hitoshi Irabu, Rie Kuroda, Raita Araki, Yasuhiro Ikawa, Hideaki Maeba, Akihiro Yachie
A 10-year-old girl developed L-asparaginase (ASP)-associated pancreatitis during chemotherapy for acute lymphocytic leukemia. Her symptoms showed alleviation with continuous regional arterial infusion of protease inhibitor and systemic somatostatin analog therapy. She had intermittent and marked hypertriglyceridemia, an initial trigger for pancreatitis, probably as a side effect of ASP and steroids. However, we considered the pancreatitis to have developed mainly because of factors other than hypertriglyceridemia as lipoprotein analysis confirmed chylomicron levels to be nearly undetectable...
August 2016: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/27594753/anesthetic-management-of-urgent-cesarean-section-with-undiagnosed-transposition-of-great-arteries
#17
Nurullah Yilmaz, Ersin Koksal, Gokce Ultan Ozgen, Ersan Ozen, Ahmet Dilek, Deniz Karakaya, Fatma Ulger
We consider that general anesthesia will be an appropriate and safe method as regional methods could lead to significant time loss in the prevention or minimization of complications. High blockage required for regional anesthetic methods in pregnant women with TGA and the maintenance of hemodynamic stability may become difficult due to neuroaxial sympathectomy even if a successful neuroaxial block has been provided. Agents with minimal effect on cardiovascular functions should be preferred for anesthesia induction and maintenance and close hemodynamic monitoring should be done during intraoperative and postoperative periods...
June 2016: Medical Archives
https://www.readbyqxmd.com/read/27591456/bilateral-greater-occipital-nerve-block-for-treatment-of-post-dural-puncture-headache-after-caesarean-operations
#18
Esra Uyar Türkyilmaz, Nuray Camgöz Eryilmaz, Nihan Aydin Güzey, Özlem Moraloğlu
BACKGROUND: Post-dural puncture headache (PDPH) is an important complication of neuroaxial anesthesia and more frequently noted in pregnant women. The pain is described as severe, disturbing and its location is usually fronto-occipital. The conservative treatment of PDPH consists of bed rest, fluid theraphy, analgesics and caffeine. Epidural blood patch is gold standard theraphy but it is an invasive method. The greater occipital nerve (GON) is formed of sensory fibers that originate in the C2 and C3 segments of the spinal cord and it is the main sensory nerve of the occipital region...
September 2016: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/27563598/the-use-of-superficial-cervical-plexus-block-in-oral-and-maxillofacial-surgical-practice-as-an-alternative-to-general-anesthesia-in-selective-cases
#19
R Kamal Kanthan
AIM: (1) To assess the feasibility, safety, and effectiveness of superficial cervical plexus (SCP) block in oral and maxillofacial surgical (OMFS) practice as an alternative to general anesthesia in selective cases. (2) To assess any associated complication specifically related to the procedure. SUBJECTS AND METHODS: The total number of patients was 10, out of which 6 were male and 4 were female patients. Six patients had incision and drainage of perimandibular space infections, two patients had Level Ib cervical lymph node biopsies, one patient had enucleation of cyst in the body of mandible, one patient had open reduction and internal fixation isolated angle fracture...
January 2016: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/27546062/bde47-induces-rat-cyp3a1-by-targeting-the-transcriptional-regulation-of-mir-23b
#20
Zhenzhen Sun, Zhan Zhang, Minghui Ji, Hongbao Yang, Meghan Cromie, Jun Gu, Chao Wang, Lu Yang, Yongquan Yu, Weimin Gao, Shou-Lin Wang
Cytochrome P450 3A (CYP3A) is the most abundant CYP450 enzyme in the liver and is involved in the metabolism of over 50% of xenobiotics. Our previous studies revealed that 2,2',4,4'-tetrabromodiphenyl ether (BDE47) could induce rat CYP3A1 expression, but the molecular basis remains unclear. Using in silico analysis, we identified a potential miR-23b recognition element (MRE23b) in the 3'-UTR region of CYP3A1 mRNA, which was verified by the luciferase assay. The miR-23b mimic and inhibitor significantly down- and up-regulated the expression of CYP3A1, respectively...
2016: Scientific Reports
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