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https://www.readbyqxmd.com/read/28526281/effects-of-maternal-immune-activation-on-brain-arginine-metabolism-of-postnatal-day-2-rat-offspring
#1
Jiaxian Zhang, Yu Jing, Hu Zhang, David K Bilkey, Ping Liu
l-Arginine is a versatile semi-essential amino acid with a number of bioactive metabolites, and altered arginine metabolism has been implicated in the pathogenesis of schizophrenia. Earlier research has demonstrated that maternal immune activation (MIA; a risk factor for schizophrenia) alters arginine metabolism in the prefrontal cortex and hippocampus of the adult offspring. The present study investigated how MIA affected the levels of l-arginine and its downstream metabolites in the whole forebrain, frontal cortex, hippocampus and cerebellum of male and female rat offspring at the age of postnatal day 2...
May 16, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28523350/comparison-of-a-radiomic-biomarker-with-volumetric-analysis-for-decoding-tumour-phenotypes-of-lung-adenocarcinoma-with-different-disease-specific-survival
#2
Mei Yuan, Yu-Dong Zhang, Xue-Hui Pu, Yan Zhong, Hai Li, Jiang-Fen Wu, Tong-Fu Yu
OBJECTIVES: To compare a multi-feature-based radiomic biomarker with volumetric analysis in discriminating lung adenocarcinomas with different disease-specific survival on computed tomography (CT) scans. METHODS: This retrospective study obtained institutional review board approval and was Health Insurance Portability and Accountability Act (HIPAA) compliant. Pathologically confirmed lung adenocarcinoma (n = 431) manifested as subsolid nodules on CT were identified...
May 18, 2017: European Radiology
https://www.readbyqxmd.com/read/28523282/comparative-study-of-computational-visual-attention-models-on-two-dimensional-medical-images
#3
Gezheng Wen, Brenda Rodriguez-Niño, Furkan Y Pecen, David J Vining, Naveen Garg, Mia K Markey
Computational modeling of visual attention is an active area of research. These models have been successfully employed in applications such as robotics. However, most computational models of visual attention are developed in the context of natural scenes, and their role with medical images is not well investigated. As radiologists interpret a large number of clinical images in a limited time, an efficient strategy to deploy their visual attention is necessary. Visual saliency maps, highlighting image regions that differ dramatically from their surroundings, are expected to be predictive of where radiologists fixate their gaze...
April 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28520708/hepatitis-b-surface-antigen-screening-among-pregnant-women-and-care-of-infants-of-hepatitis-b-surface-antigen-positive-mothers-guam-2014
#4
Winston E Abara, Susan Cha, Tasneem Malik, Mia S DeSimone, Bernadette Schumann, Esther Mallada, Michael Klemme, Vince Aguon, Anne Marie Santos, Melissa Collier, Mary Kamb
Hepatitis B virus (HBV) infection is endemic among adults in the U.S. territory of Guam (1,2). Perinatal HBV transmission, which occurs at birth from an infected mother to her newborn infant, is a major mode of HBV transmission and maintains HBV endemicity (3). Approximately 90% of HBV-infected infants will develop chronic HBV infection, and approximately 25% of those will die prematurely from liver failure or hepatocellular carcinoma (4,5). Since 1988, the Advisory Committee on Immunization Practices has recommended that all pregnant women be screened for hepatitis B surface antigen (HBsAg), an indicator of HBV infection, and that infants of women who screen positive (HBsAg-positive women) receive postexposure prophylaxis (PEP) (hepatitis B vaccine and hepatitis B immunoglobulin [HBIG])...
May 19, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28518345/severe-neonatal-alloimmune-thrombocytopenia-caused-by-maternal-sensitization-against-a-new-low-frequency-alloantigen-dom-b-located-on-platelet-glycoprotein-iiia
#5
Mia J Sullivan, Randy Kuhlmann, Julie A Peterson, Brian R Curtis
No abstract text is available yet for this article.
May 18, 2017: Transfusion
https://www.readbyqxmd.com/read/28516214/interactions-of-cisplatin-and-the-copper-transporter-ctr1-in-human-colon-cancer-cells
#6
Mia C Akerfeldt, Carmen M-N Tran, Clara Shen, Trevor W Hambley, Elizabeth J New
There is much interest in understanding the mechanisms by which platinum-based anticancer agents enter cells, and the copper transporter CTR1 has been the focus of many recent studies. While there is a clinical correlation between CTR1 levels and platinum efficacy, cellular studies have provided conflicting evidence relating to the relationship between cisplatin and CTR1. We report here our studies of the relationship between cisplatin and copper homeostasis in human colon cancer cells. While the accumulation of copper and platinum do not appear to compete with each other, we did observe that cisplatin perturbs CTR1 distribution within 10 min, a far shorter incubation time than commonly employed in cellular studies of cisplatin...
May 17, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28515522/comparison-of-airtraq%C3%A2-mccoy%C3%A2-and-macintosh-laryngoscopes-for-endotracheal-intubation-in-patients-with-cervical-spine-immobilisation-a-randomised-clinical-trial
#7
Vinod Hosalli, B K Arjun, Uday Ambi, Shivanand Hulakund
BACKGROUND AND AIMS: The study aimed at comparing the performance of the novel optical Airtraq™ laryngoscope with the McCoy™ and conventional Macintosh laryngoscopes for ease of endotracheal intubation in patients with neck immobilisation using manual inline axial cervical spine stabilisation (MIAS) technique. METHODS: Ninety consenting American Society of Anaesthesiologist's physical status I-II patients, aged 18-60 years, scheduled for various surgeries requiring tracheal intubation were randomly assigned into three groups of thirty each to undergo intubation with Macintosh, Airtraq™, or McCoy™ laryngoscope with neck immobilisation by MIAS technique...
April 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28515448/involvement-of-vascular-aldosterone-synthase-in-phosphate-induced-osteogenic-transformation-of-vascular-smooth-muscle-cells
#8
Ioana Alesutan, Jakob Voelkl, Martina Feger, Denise V Kratschmar, Tatsiana Castor, Sobuj Mia, Michael Sacherer, Robert Viereck, Oliver Borst, Christina Leibrock, Meinrad Gawaz, Makoto Kuro-O, Stefan Pilz, Andreas Tomaschitz, Alex Odermatt, Burkert Pieske, Carsten A Wagner, Florian Lang
Vascular calcification resulting from hyperphosphatemia is a major determinant of mortality in chronic kidney disease (CKD). Vascular calcification is driven by aldosterone-sensitive osteogenic transformation of vascular smooth muscle cells (VSMCs). We show that even in absence of exogenous aldosterone, silencing and pharmacological inhibition (spironolactone, eplerenone) of the mineralocorticoid receptor (MR) ameliorated phosphate-induced osteo-/chondrogenic transformation of primary human aortic smooth muscle cells (HAoSMCs)...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28514242/risks-of-cardiovascular-adverse-events-and-death-in-patients-with-previous-stroke-undergoing-emergency-noncardiac-nonintracranial-surgery-the-importance-of-operative-timing
#9
Mia N Christiansen, Charlotte Andersson, Gunnar H Gislason, Christian Torp-Pedersen, Robert D Sanders, Per Føge Jensen, Mads E Jørgensen
BACKGROUND: The outcomes of emergent noncardiac, nonintracranial surgery in patients with previous stroke remain unknown. METHODS: All emergency surgeries performed in Denmark (2005 to 2011) were analyzed according to time elapsed between previous ischemic stroke and surgery. The risks of 30-day mortality and major adverse cardiovascular events were estimated as odds ratios (ORs) and 95% CIs using adjusted logistic regression models in a priori defined groups (reference was no previous stroke)...
May 17, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28509696/on-top-index-pollicization-after-a-partial-amputation-of-a-syndactylized-hypoplastic-thumb-in-a-patient-with-townes-brocks-syndrome
#10
Mia Lorencin, Kresimir Bulic
Townes-Brocks syndrome is a rare autosomal dominant syndrome characterized by multiple malformations, including thumb anomalies. Thumb hypoplasia poses a specific problem, where a deficient thumb creates a significant handicap in hand function. The treatment goal is enabling pinch and grip activity, and the preferred procedure for a severely hypoplastic thumb is index finger pollicization. We present a case of on-top index pollicization in a 10-year-old, after a partial amputation of a previously syndactylized hypoplastic thumb, with a well-formed first carpometacarpal joint...
May 15, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28507472/schisandrae-fructus-ethanol-extract-ameliorates-inflammatory-responses-and-articular-cartilage-damage-in-monosodium-iodoacetate-induced-osteoarthritis-in-rats
#11
Jin-Woo Jeong, Jongsik Kim, Eun Ok Choi, Da Hye Kwon, Gyu Min Kong, Il-Whan Choi, Bum Hoi Kim, Gi-Young Kim, Ki Won Lee, Ki Young Kim, Sung Goo Kim, Young Whan Choi, Su Hyun Hong, Cheol Park, Yung Hyun Choi
Schisandrae Fructus, the fruit of Schisandra chinensis (Turcz.) Baill., is widely used in traditional medicine for the treatment of a number of chronic diseases. Although, Schisandrae Fructus was recently reported to attenuate the interleukin (IL)-1β-induced inflammatory response in chondrocytes in vitro, its protective and therapeutic potential against osteoarthritis (OA) in an animal model remains unclear. Therefore, we investigated the effects of the ethanol extract of Schisandrae Fructus (SF) on inflammatory responses and cartilage degradation in a monosodium iodoacetate (MIA)-induced OA rat model...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28504116/exercise-reverses-pain-related-weight-asymmetry-and-differentially-modulates-trabecular-bone-microarchitecture-in-a-rat-model-of-osteoarthritis
#12
Jim Cormier, Katherine Cone, Janell Lanpher, Abigail Kinens, Terry Henderson, Lucy Liaw, Edward J Bilsky, Tamara King, Clifford J Rosen, Glenn W Stevenson
There is great interest in developing and utilizing non-pharmacological/non-invasive forms of therapy for osteoarthritis (OA) pain including exercise and other physical fitness regimens. AIMS: The present experiments determined the effects of prior wheel running on OA-induced weight asymmetry and trabecular bone microarchitecture. MAIN METHODS: Wheel running included 7 or 21days of prior voluntary access to wheels followed by OA induction, followed by 21days post-OA access to wheels...
May 11, 2017: Life Sciences
https://www.readbyqxmd.com/read/28502647/an-accurate-specific-sensitive-high-throughput-method-based-on-a-microsphere-immunoassay-for-multiplex-detection-of-three-viruses-and-bacterial-fruit-blotch-bacterium-in-cucurbits
#13
Ratthaphol Charlermroj, Manlika Makornwattana, Orawan Himananto, Channarong Seepiban, Sudtida Phuengwas, Nuchnard Warin, Oraprapai Gajanandana, Nitsara Karoonuthaisiri
To employ a microsphere immunoassay (MIA) to simultaneously detect multiple plant pathogens (potyviruses, Watermelon silver mottle virus, Melon yellow spot virus, and Acidovorax avenae subsp. citrulli) in actual plant samples, several factors need to be optimized and rigorously validated. Here, a simple extraction method using a single extraction buffer was successfully selected to detect the four pathogens in various cucurbit samples (cucumber, cantaloupe, melon, and watermelon). The extraction method and assay performance were validated with inoculated and field cucurbit samples...
May 11, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28500966/synthesis-of-novel-benzylidene-analogues-of-betulinic-acid-as-potent-cytotoxic-agents
#14
Nidhi Gupta, Santosh K Rath, Jasvinder Singh, Arem Qayum, Shashank Singh, Payare L Sangwan
Different benzylidene derivatives (15a-o and 16a-o) of betulinic acid were designed and synthesized in an effort to develop potent anticancer agents. All the synthesized derivatives along with betulinic acid were evaluated for cytotoxicity against a panel of five different human cancer cell lines A-549 (Lung), PC-3 (Prostate), HCT 116 (Colon), MCF-7 (Breast) and MIA PaCa-2 (Pancreatic) using SRB assay. Pharmacological results showed that compounds 15b, 15c, 15i, 15k, 16a-c and 16l were found to have promising cytotoxic profile against various cancer cell lines tested (IC50 1-2 μM)...
April 25, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28500224/evaluating-the-safety-of-%C3%AE-interferons-in-ms-a-series-of-nested-case-control-studies
#15
Hilda J I de Jong, Elaine Kingwell, Afsaneh Shirani, Jan Willem Cohen Tervaert, Raymond Hupperts, Yinshan Zhao, Feng Zhu, Charity Evans, Mia L van der Kop, Anthony Traboulsee, Paul Gustafson, John Petkau, Ruth Ann Marrie, Helen Tremlett
OBJECTIVE: To examine the association between interferon-β (IFN-β) and potential adverse events using population-based health administrative data in British Columbia, Canada. METHODS: Patients with relapsing-remitting multiple sclerosis (RRMS) who were registered at a British Columbia Multiple Sclerosis Clinic (1995-2004) were eligible for inclusion and were followed up until death, absence from British Columbia, exposure to a non-IFN-β disease-modifying drug, or December 31, 2008...
May 12, 2017: Neurology
https://www.readbyqxmd.com/read/28498896/inhibition-of-prdm14-expression-in-pancreatic-cancer-suppresses-cancer-stem-like-properties-and-liver-metastasis-in-mice
#16
Chiharu Moriya, Hiroaki Taniguchi, Kanjiro Miyata, Nobuhiro Nishiyama, Kazunori Kataoka, Kohzoh Imai
Pancreatic cancer is one of the most lethal types of cancer, with aggressive properties characterized by metastasis, recurrence, and drug resistance. Cancer stem cells are considered to be responsible for these properties. PRDM14, a transcriptional regulator that maintains pluripotency in embryonic stem cells, is overexpressed in some cancers. Here, we assessed PRDM14 expression and the effects of PRDM14 knockdown on cancer stem-like phenotypes in pancreatic cancer. We observed that PRDM14 protein was overexpressed in pancreatic cancer tissues compared with normal pancreatic tissues...
May 12, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28497655/nicotine-self-administration-reverses-cognitive-deficits-in-a-rat-model-for-schizophrenia
#17
Uta Waterhouse, Katharine A Brennan, Bart A Ellenbroek
High comorbidity between schizophrenia and tobacco addiction has been well established. Explanatory theories include nicotine as a cognitive enhancer ameliorating symptoms of schizophrenia and underlying shared substrates increasing susceptibility to addiction in these individuals. To test these non-mutually exclusive theories, the maternal immune activation (MIA) model was utilized. To this end, pregnant Sprague Dawley rats were subcutaneously injected with a bacterial endotoxin, lipopolysaccharide (0.5 mg/kg), on gestation days 10 and 11...
May 12, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28496359/efficacy-of-cr4056-a-first-in-class-imidazoline-2-analgesic-drug-in-comparison-with-naproxen-in-two-rat-models-of-osteoarthritis
#18
Eleonora Comi, Marco Lanza, Flora Ferrari, Valeria Mauri, Gianfranco Caselli, Lucio Claudio Rovati
PURPOSE: CR4056, (2-phenyl-6-(1H-imidazol-1yl) quinazoline), an imidazoline-2 (I2) receptor ligand, is a promising analgesic drug that has been reported to be effective in several animal models of pain. The aim of this study was to evaluate the effects of CR4056 in two well-established rat models of osteoarthritis (OA), mimicking the painful and structural components of human OA. METHODS: Knee OA was induced either by single intra-articular injection of monoiodoacetate (MIA) or by medial meniscal tear (MMT) in the right knee of male rats...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28490735/design-synthesis-and-biological-evaluation-of-novel-hedgehog-inhibitors-for-treating-pancreatic-cancer
#19
Vinod Kumar, Amit Kumar Chaudhary, Yuxiang Dong, Haizhen A Zhong, Goutam Mondal, Feng Lin, Virender Kumar, Ram I Mahato
Hedgehog (Hh) pathway is involved in epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) maintenance resulting in tumor progression. GDC-0449, an inhibitor of Hh pathway component smoothened (Smo) has shown promise in the treatment of various cancers including pancreatic cancer. However, the emergence of resistance during GDC-0449 treatment with numerous side effects limits its use. Therefore, here we report the design, synthesis and evaluation of novel GDC-0449 analogs using N-[3-(2-pyridinyl) phenyl] benzamide scaffold...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28489730/improved-hiv-1-viral-load-monitoring-capacity-using-pooled-testing-with-marker-assisted-deconvolution
#20
Tao Liu, Joseph W Hogan, Michael J Daniels, Mia Coetzer, Yizhen Xu, Gerald Bove, Allison K Delong, Lauren Ledingham, Millicent Orido, Lameck Diero, Rami Kantor
OBJECTIVE: Improve pooled viral load (VL) testing to increase HIV treatment monitoring capacity, particularly relevant for resource-limited settings. DESIGN: We developed mMPA (marker-assisted mini-pooling with algorithm), a new VL pooling deconvolution strategy that utilizes information from low-cost, routinely-collected clinical markers to determine an efficient order of sequential individual VL testing and dictates when the sequential testing can be stopped. METHODS: We simulated the use of pooled testing to ascertain virological failure status on 918 participants from three studies conducted at the Academic Model Providing Access to Healthcare (AMPATH) in Eldoret, Kenya, and estimated the number of assays needed when using mMPA and other pooling methods...
April 25, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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