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https://www.readbyqxmd.com/read/28733907/multiple-intracranial-aneurysms-a-direct-hemodynamic-comparison-between-ruptured-and-unruptured-vessel-malformations
#1
Philipp Berg, Oliver Beuing
PURPOSE: Despite numerous studies addressing the rupture risk of intracranial aneurysms that have been published, the assessment thereof still remains challenging. Image-based simulations enable a precise prediction of patient-specific blood flow information. However, those approaches normally consider only small segments of the complete cerebral vasculature. METHODS: To test the validity of the consideration of single aneurysms in one computational setup, domains of the complete anterior and posterior circulations with multiple intracranial aneurysms (MIA) were simulated...
July 21, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28731891/white-wine-consumption-influences-inflammatory-phase-of-repair-following-myocardial-infarction-in-rats
#2
Nikola Ključević, Ana Marija Milat, Mia Grga, Ivana Mudnić, Mladen Boban, Ivica Grković
Effects of white wine consumption on the expression of inflammatory markers/mediators (MMP-2, MMP-9, NF-ĸB p65 and TGF-β1) in myocardial tissue following experimentally induced permanent myocardial ischemia was investigated. Male Sprague-Dawley rats were given either a combination of white wine and water or water only, for 28 days. After coronary ligation, animals were left to survive for 24 hours. Three representative areas: infarct/ischemic, peri-infarct/border zone and control/non-ischemic zones were analysed for expression of immunoreactivity by measuring threshold area % of signal density...
July 19, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28731719/discovery-structure-activity-relationship-and-binding-mode-of-imidazo-1-2-a-pyridine-series-of-autotaxin-inhibitors
#3
Agnès Joncour, Nicolas Desroy, Christopher Housseman, Xavier Bock, Natacha Bienvenu, Laëtitia Cherel, Virginie Labeguere, Christophe Peixoto, Denis Annoot, Luce Lepissier, Jörg Heiermann, Willem Jan Hengeveld, Gregor Pilzak, Alain Monjardet, Emanuelle Wakselman, Veronique Roncoroni, Sandrine Le Tallec, René Galien, Christelle David, Nele Vandervoort, Thierry Christophe, Katja Conrath, Mia Jans, Alexandre Wohlkonig, Robert Touitou, Damien Fleury, Lionel Vercheval, Patrick Mollat, Nicolas Triballeau, Ellen Van der Aar, Reginald Brys, Bertrand Heckmann
Autotaxin (ATX) is a secreted enzyme playing a major role in the production of lysophosphatidic acid (LPA) in blood through hydrolysis of lysophosphatidyl choline (LPC). The ATX-LPA signaling axis arouses a high interest in the drug discovery industry as it has been implicated in several diseases including cancer, fibrotic diseases and inflammation among others. An imidazo[1,2-a]pyridine series of ATX inhibitors was identified out of a high throughput screening (HTS). A co-crystal structure with one of these compounds and ATX revealed a novel binding mode with occupancy of the hydrophobic pocket and channel of ATX but no interaction with zinc ions of the catalytic site...
July 21, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28731575/the-automation-of-regression-modeling-in-osteometric-sorting-an-ordination-approach
#4
Jeffrey James Lynch
This study compares the original osteometric sorting association method with an ordination approach across all combinations of the humerus, ulna, radius, femur, tibia, and fibula. This includes both the original prediction interval and t-statistic approaches. Standard measurements are utilized in the models with full measurements combined and without length measurements. The sample is the osteometric sorting reference from the Defense POW/MIA Accounting Agency. A full set of performance statistics is provided...
July 21, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28730863/non-operative-management-of-ulnar-collateral-ligament-injuries-in-the-throwing-athlete
#5
Mia Smucny, Robert W Westermann, Matthew Winters, Mark S Schickendantz
Medial ulnar collateral ligament (UCL) injuries have become increasingly prevalent in overhead athletes. The orthopaedic literature contains a wealth of information on operative management of these injuries. However, there are few high-quality longitudinal studies on non-operative care of UCL injuries. The purpose of this review is to describe the non-operative approach to managing UCL injuries, including recommended rehabilitation strategies and predictors of successful non-operative treatment.
July 21, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/28730536/effectiveness-and-feasibility-of-robotic-gastric-neurostimulator-placement-in-patients-with-refractory-gastroparesis
#6
Mia Mowzoon, Francisco Igor B Macedo, Jaskiran Kaur, Ramachandra Kolachalam
Gastric neurostimulation (GNS) with Enterra(®) therapy device (Medtronic, Minneapolis, MN) appears as the last resort for patients with refractory gastroparesis. Currently, the device has Humanitarian Use status by Food and Drug Administration, thereby requiring further investigation. We aim to describe its feasibility and clinical outcomes using robotic technique. From June 2014 to September 2016, 15 consecutive patients underwent robotic insertion of Enterra(®) device. Patient demographics, comorbidities, and clinical outcomes including mortality, length of stay, readmission rates, reoperation and complications were retrospectively collected...
July 20, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28729400/vessel-targeted-chemophototherapy-with-cationic-porphyrin-phospholipid-liposomes
#7
Dandan Luo, Jumin Geng, Nasi Li, Kevin A Carter, Shuai Shao, G Ekin Atilla-Gokcumen, Jonathan F Lovell
Cationic liposomes have been used for targeted drug delivery to tumor blood vessels, via mechanisms that are not fully elucidated. Doxorubicin (Dox)-loaded liposomes were prepared that incorporate a cationic lipid; 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), along with a small amount of porphyrin-phospholipid (PoP). Near infrared (NIR) light induced release of entrapped Dox via PoP-mediated DOTAP photo-oxidation. The formulation was optimized to enable extremely rapid NIR light-triggered Dox release (i...
July 20, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28727546/a-formative-evaluation-of-a-diabetes-prevention-program-using-the-re-aim-framework-in-a-learning-health-care-system-utah-2013-2015
#8
Kimberly D Brunisholz, Jaewhan Kim, Lucy A Savitz, Mia Hashibe, Lisa H Gren, Sharon Hamilton, Kelly Huynh, Elizabeth A Joy
INTRODUCTION: Evaluation of interventions can help to close the gap between research and practice but seldom takes place during implementation. Using the RE-AIM framework, we conducted a formative evaluation of the first year of the Intermountain Healthcare Diabetes Prevention Program (DPP). METHODS: Adult patients who met the criteria for prediabetes (HbA1c of 5.70%-6.49% or fasting plasma glucose of 100-125 mg/dL) were attributed to a primary care provider from August 1, 2013, through July 31, 2014...
July 20, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28726805/prepl-deficiency-delineation-of-the-phenotype-and-development-of-a-functional-blood-assay
#9
Luc Régal, Emma Mårtensson, Isabelle Maystadt, Nicol Voermans, Damien Lederer, Alberto Burlina, María Jesús Juan Fita, A Jeannette M Hoogeboom, Mia Olsson Engman, Tess Hollemans, Meyke Schouten, Sandra Meulemans, Tord Jonson, Inge François, David Gil Ortega, Erik-Jan Kamsteeg, John W M Creemers
PurposePREPL deficiency causes neonatal hypotonia, ptosis, neonatal feeding difficulties, childhood obesity, xerostomia, and growth hormone deficiency. Different recessive contiguous gene deletion syndromes involving PREPL and a variable combination of SLC3A1 (hypotonia-cystinuria syndrome), CAMKMT (atypical hypotonia-cystinuria syndrome), and PPM1B (2p21 deletion syndrome) have been described. In isolated PREPL deficiency, previously described only once, the absence of cystinuria complicates the diagnosis...
July 20, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28724618/initiation-of-sevelamer-and-mortality-among-hemodialysis-patients-treated-with-calcium-based-phosphate-binders
#10
Hirotaka Komaba, Mia Wang, Masatomo Taniguchi, Suguru Yamamoto, Takanobu Nomura, Douglas E Schaubel, Abigail R Smith, Jarcy Zee, Angelo Karaboyas, Brian Bieber, Masafumi Fukagawa, Francesca Tentori
BACKGROUND AND OBJECTIVES: Prior studies have shown that sevelamer attenuates progression of arterial calcification and may reduce the risk of death compared with calcium-based phosphate binders. In clinical practice, however, sevelamer is used not only as an alternative but also as an add-on therapy in patients already being treated with calcium-based phosphate binders. We analyzed the Dialysis Outcomes and Practice Patterns Study (DOPPS) data to test the hypothesis that the initiation of sevelamer is associated with improved survival in patients on hemodialysis treated with calcium-based phosphate binders...
July 19, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28722777/nurses-and-nurse-assistants-beliefs-attitudes-and-actions-related-to-role-and-function-in-an-inpatient-stroke-rehabilitation-unit-a-qualitative-study
#11
Mia Ingerslev Loft, Ingrid Poulsen, Bente Appel Esbensen, Helle Klingenberg Iversen, Lone Lunbak Mathiesen, Bente Martinsen
AIMS AND OBJECTIVE: To explore nurses' and nurse assistants' beliefs, attitudes, and actions related to their function in an inpatient stroke rehabilitation unit. BACKGROUND: Several attempts have been made to describe nurses' roles and functions in inpatient neurorehabilitation. However, current understandings of the contributions that nurses and nurse assistants make to neurorehabilitation remain sparse. DESIGN: Descriptive, interpretive qualitative study...
July 19, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28719220/egfr-targeted-cationic-polymeric-mixed-micelles-for-co-delivery-of-gemcitabine-and-mir-205-for-treating-advanced-pancreatic-cancer
#12
Goutam Mondal, Saud Almawash, Amit Kumar Chaudhary, Ram I Mahato
Gemcitabine (GEM), a first-line chemotherapy for pancreatic cancer undergoes rapid metabolism and develops chemoresistance after repeated administration. We previously demonstrated that the combination of GEM and miR-205 provides an effective therapeutic strategy to sensitize GEM-resistant pancreatic cancer cells. Since epidermal growth factor receptor (EGFR) is overexpressed in pancreatic cancer cells, in this study, we aimed to deliver mixed micelles containing GEM and miR-205 decorated with EGFR-targeting cetuximab (C225) monoclonal antibody for targeted therapy...
July 18, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28718882/an-analysis-on-the-choice-of-alpha-level-in-the-osteometric-pair-matching-of-the-os-coxa-scapula-and-clavicle
#13
Jeffrey James Lynch
This study compares the use of 0.05 and 0.10 alpha levels with the updated osteometric pair-matching model on two samples of the os coxa, scapula, and clavicle. The samples include the Forensic Data Bank, and the osteometric sorting reference used within the Defense POW/MIA Accounting Agency. Mixed-effects two-way analyses of variance were used to analyze bilateral asymmetry in the standard measurements. In total, 3,793,566 t-tests were conducted for osteometric pair-matching analysis. The results indicate high levels of exclusion power, and accuracy can be obtained with the os coxa and scapula...
July 18, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28718862/preventivt-arbete-kan-minska-l%C3%A3-kemedelsbiverkningar
#14
Pär Hallberg, Sofie Collin, Mia Wadelius
No abstract text is available yet for this article.
July 14, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28717858/complete-nucleotide-sequence-of-a-novel-bovine-viral-diarrhea-virus-subtype-1-isolate-from-italy
#15
Moira Bazzucchi, Luigi Bertolotti, Letizia Ceglie, Monica Giammarioli, Elisabetta Rossi, Sergio Rosati, Gian Mario De Mia
To gain further insight into the genomic features of bovine viral diarrhea virus 1 (BVDV-1) subtypes, we sequenced the complete genome of the BVDV-1 isolate VE/245/12. This is an uncommon subtype that was isolated from a persistently infected animal. Here, we report the complete genome sequence, consisting of 12,295 nucleotides (nt) with an open reading frame of 11,694 nt encoding 3,898 amino acids. Phylogenetic analysis of the full-length genome, 5'-UTR, and N(pro) region confirmed that the BVDV-1 isolate differed significantly from all of the bovine pestiviruses identified so far, providing evidence for the presence of a distinct novel genetic group...
July 17, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28716313/telemedicine-for-management-of-inflammatory-bowel-disease-myibdcoach-a-pragmatic-multicentre-randomised-controlled-trial
#16
Marin J de Jong, Andrea E van der Meulen-de Jong, Mariëlle J Romberg-Camps, Marco C Becx, Jeroen P Maljaars, Mia Cilissen, Ad A van Bodegraven, Nofel Mahmmod, Tineke Markus, Wim M Hameeteman, Gerard Dijkstra, Ad A Masclee, Annelies Boonen, Bjorn Winkens, Astrid van Tubergen, Daisy M Jonkers, Marie J Pierik
BACKGROUND: Tight and personalised control of inflammatory bowel disease in a traditional setting is challenging because of the disease complexity, high pressure on outpatient clinics, and rising incidence. We compared the effects of self-management with a telemedicine system, which was developed for all subtypes of inflammatory bowel disease, on health-care utilisation and patient-reported quality of care versus standard care. METHODS: We did this pragmatic, randomised trial in two academic and two non-academic hospitals in the Netherlands...
July 14, 2017: Lancet
https://www.readbyqxmd.com/read/28716065/the-validity-of-the-sf-12-and-sf-6d-instruments-in-people-living-with-hiv-aids-in-kenya
#17
Anik R Patel, Richard T Lester, Carlo A Marra, Mia L van der Kop, Paul Ritvo, Lidia Engel, Sarah Karanja, Larry D Lynd
BACKGROUND: Health-related quality of life (HRQoL) and health state utility value (HSUV) measurements are vital components of healthcare clinical and economic evaluations. Accurate measurement of HSUV and HRQoL require validated instruments. The 12-item Short-Form Health Survey (SF-12) is one of few instruments that can evaluate both HRQoL and HSUV, but its validity has not been assessed in people living with HIV/AIDS (PLWHA) in east Africa, where the burden of HIV is high. METHODS: This cross-sectional study used baseline data from a randomized trial involving PLWHA in Kenya...
July 17, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28715440/transcriptional-profiling-of-the-rat-nucleus-accumbens-after-modest-or-high-alcohol-exposure
#18
Julia Morud, Arghavan Ashouri, Erik Larsson, Mia Ericson, Bo Söderpalm
Alcohol use disorder is a chronic relapsing brain disorder and a global health issue. Prolonged high alcohol consumption increases the risk for dependence development, a complex state that includes progressive alterations in brain function. The molecular mechanisms behind these changes remain to be fully disclosed, but several genes show altered expression in various regions of the rat brain even after modest alcohol exposure. The present study utilizes whole-transcriptome sequencing (RNA-seq) to investigate expression changes in the brain nucleus accumbens (NAc), an area of particular interest in addictive disorders, of alcohol consuming rats...
2017: PloS One
https://www.readbyqxmd.com/read/28710831/dietary-fiber-intake-and-head-and-neck-cancer-risk-a-pooled-analysis-in-the-international-head-and-neck-cancer-epidemiology-consortium
#19
Daisuke Kawakita, Yuan-Chin Amy Lee, Federica Turati, Maria Parpinel, Adriano Decarli, Diego Serraino, Keitaro Matsuo, Andrew F Olshan, Jose P Zevallos, Deborah M Winn, Kirsten Moysich, Zuo-Feng Zhang, Hal Morgenstern, Fabio Levi, Karl Kelsey, Michael McClean, Cristina Bosetti, Werner Garavello, Stimson Schantz, Guo-Pei Yu, Paolo Boffetta, Shu-Chun Chuang, Mia Hashibe, Monica Ferraroni, Carlo La Vecchia, Valeria Edefonti
The possible role of dietary fiber in the etiology of head and neck cancers (HNCs) is unclear. We used individual-level pooled data from 10 case-control studies (5959 cases and 12,248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium, to examine the association between fiber intake and cancer of the oral cavity/pharynx and larynx. Odds Ratios (ORs) and their 95% Confidence Intervals (CIs) were estimated using unconditional multiple logistic regression applied to quintile categories of non-alcohol energy-adjusted fiber intake and adjusted for tobacco and alcohol use and other known or putative confounders...
July 14, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28710575/software-based-risk-stratification-of-pulmonary-adenocarcinomas-manifesting-as-pure-ground-glass-nodules-on-computed-tomography
#20
Ursula Nemec, Benedikt H Heidinger, Kevin R Anderson, Michael S Westmore, Paul A VanderLaan, Alexander A Bankier
OBJECTIVES: To assess the performance of the "Computer-Aided Nodule Assessment and Risk Yield" (CANARY) software in the differentiation and risk assessment of histological subtypes of lung adenocarcinomas manifesting as pure ground glass nodules on computed tomography (CT). METHODS: 64 surgically resected and histologically proven adenocarcinomas manifesting as pure ground-glass nodules on CT were assessed using CANARY software, which classifies voxel-densities into three risk components (low, intermediate, and high risk)...
July 14, 2017: European Radiology
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