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gangyong huang

Gangyong Huang, Guanglei Zhao, Jun Xia, Yibing Wei, Feiyan Chen, Jie Chen, Jingsheng Shi
Osteonecrosis of the femoral head (ONFH) is a common orthopedic disease associated with high disability, and femoral neck fracture (FNF) is one of the most common reasons for traumatic ONFH. This study was designed to reveal the mechanisms underlying ONFH. Using fastx_toolkit and prinseq-lite tools, quality control was conducted for the sequencing data. The differentially expressed genes (DEGs, including both mRNAs and lncRNAs) between ONFH and FNF samples were identified using the edgeR package in R, and were then subjected to enrichment analysis using the BioCloud platform...
January 27, 2018: Gene
Gangyong Huang, Yibing Wei, Guanglei Zhao, Jun Xia, Siqun Wang, Jianguo Wu, Feiyan Chen, Jie Chen, Jingshen Shi
The underlying mechanisms of glucocorticoid (GC)‑induced avascular necrosis of the femoral head (ANFH) have yet to be fully understood, in particular the mechanisms associated with the change of gene expression pattern. The present study aimed to identify key genes with a differential expression pattern in GC‑induced ANFH. E‑MEXP‑2751 microarray data were downloaded from the ArrayExpress database. Differentially expressed genes (DEGs) were identified in 5 femoral head samples of steroid‑induced ANFH rats compared with 5 placebo‑treated rat samples...
June 2017: Molecular Medicine Reports
Gangyong Huang, Jun Xia, Siqun Wang, Yibing Wei, Jianguo Wu, Feiyan Chen, Jie Chen, Jingsheng Shi
BACKGROUND: Apart from transepicondylar axis, the native femoral sulcus was also reported to be used as a guide for the femoral component position in total knee arthroplasty (TKA). However, it was not shown in patients with severe knee osteoarthritis. This study was conducted to compare the position of trochlear groove in patients with and without osteoarthritis, and to assess whether trochlear groove could be used as a guide for position of femoral component in TKA for severe knee osteoarthritis...
May 23, 2016: BMC Surgery
Gangyong Huang, Jianguo Wu, Siqun Wang, Yibing Wei, Feiyan Chen, Jie Chen, Jingsheng Shi, Jun Xia
CONTEXT: Pycnogenol(®) extracted from French maritime pine bark (Pinus pinaster Ait. subsp. atlantica) is functional for its antioxidant activity. OBJECTIVE: To investigate the effects of Pycnogenol(®) on bone mineral density (BMD), trabecular microarchitecture and bone metabolism in ovariectomized (OVX) rats. MATERIALS AND METHODS: Thirty Sprague-Dawley rats were randomized into 3 groups: SHAM group (sham-operated rats), OVX group (OVX rats), and treatment group (OVX rats supplemented with 40 mg/kg Pycnogenol(®) by oral gavage)...
2015: International Journal of Clinical and Experimental Medicine
Shi Jingsheng, Wei Yibing, Xia Jun, Wang Siqun, Wu Jianguo, Chen Feiyan, Huang Gangyong, Chen Jie
Osteoarthritis is an aging-related degenerative disease that severely influences the elders' life quality. However, there have been few clinical approaches available until now. Currently, more knowledge of the pathology of osteoarthritis has been illustrated. Especially, diabetes can be the only predictor of osteoarthritis. Due to its outstanding characteristics, MicroRNA has been considered as an efficient target in treating diseases. In this review, we will discuss a new insight focusing on the roles of microRNA in the progression of osteoarthritis-induced by diabetes, especially type II diabetes mellitus...
January 2015: Journal of Bone and Mineral Metabolism
Siqun Wang, Jun Xia, Yibin Wei, Jianguo Wu, Gangyong Huang
OBJECTIVE: This study investigated the effect of the knee position during wound closure on early knee function recovery after total knee arthroplasty (TKA). METHODS: This study included 80 primary total knee arthroplasties due to osteoarthritis. The patients were randomized according to the type of wound closure: extension group for full extension and flexion group for 90° flexion. The incision of articular capsule was marked for precise wound alignment. In the flexion group, the knee was kept in high flexion for 1 to 2 min after wound closure...
2014: Journal of Orthopaedic Surgery and Research
JingSheng Shi, Jun Xia, YiBing Wei, SiQun Wang, JianGuo Wu, FeiYan Chen, GangYong Huang, Jie Chen
BACKGROUND: Dextroscope® three-dimensional (3D) imaging has been extensively used to generate virtual reality (VR) workspaces for neurosurgery and laparoscopy, but few applications have been reported for orthopedic surgery. Here, we investigated orthopedic periarticular tumor surgery planning and anatomical characteristics using a Dextroscope. MATERIAL AND METHODS: Patients undergoing surgery for periarticular tumors (n=10) between October 2008 and June 2010 were enrolled and presurgically subjected to computed tomography (CT), magnetic resonance imaging (MRI), and MRI angiography (MRI-A)...
2014: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
JingSheng Shi, Jun Xia, YiBing Wei, SiQun Wang, JianGuo Wu, FeiYan Chen, GangYong Huang, Jie Chen
UNLABELLED: Dextroscope three-dimensional (3D) imaging has been extensively applied for generation of virtual reality (VR) workspaces for in neurosurgery and laparoscopy, though few applications in orthopedic surgery have been reported. Patients undergoing surgery for periarticular tumors (n = 10) from Oct. 2008 to Jun. 2010 were enrolled and presurgically subjected to computed tomography (CT), magnetic resonance imaging (MRI), and MRI angiography (MRI-A). Imaging data was transferred and integrated in Dextroscope, producing a VR simulation...
March 2014: Acta Orthopaedica Belgica
Jingsheng Shi, Yibing Wei, Jun Xia, Siqun Wang, Jianguo Wu, Feiyan Chen, Gangyong Huang, Jie Chen
The CXCL12-CXCR4 axis is postulated to be a key pathway in the interaction between (cancer) stem cells and their surrounding supportive cells in the (cancer) stem cell niche. As the bone marrow constitutes a unique microenvironment for cancer cells, the CXCL12-CXCR4 axis assists the bone marrow in regulating cancer progression. This interaction can be disrupted by CXCR4 antagonists, and this concept is being used clinically to harvest hematopoietic stem/progenitor cells from the bone marrow. The functions of CXCL12-CXCR4 axis in cancer cell-tumor microenvironment interaction and angiogenesis have been recently studied...
April 2014: Future Oncology
Jingsheng Shi, Yibing Wei, Siqun Wang, Feiyan Chen, Jianguo Wu, Gangyong Huang, Jie Chen, Licheng Wei, Jun Xia
Research has added evidence in favor of computer-navigated techniques over conventional surgery for total knee arthroplasty (TKA). The goal of the current meta-analysis was to compare the outcome of outliers in mechanical axis and postoperative complications in patients undergoing conventional vs computer-navigated techniques for TKA. English literature searches were performed in PubMed, EMBASE, Web of Science, and the Cochrane Library for studies published between January 2002 and August 2012. Randomized, controlled trials comparing computer navigation with conventional surgery for the measurement of mechanical axes in patients with primary osteoarthritis were considered eligible...
January 2014: Orthopedics
Zheyong Huang, Yunli Shen, Aijun Sun, Gangyong Huang, Hongmin Zhu, Bingqing Huang, Jianfeng Xu, Yanan Song, Ning Pei, Jing Ma, Xiangdong Yang, Yunzeng Zou, Juying Qian, Junbo Ge
INTRODUCTION: Retrograde coronary venous infusion is a promising delivery method for cellular cardiomyoplasty. Poor cell retention is the major obstacle to the establishment of this method as the preferred route for cell delivery. Here, we explored whether magnetic targeting could enhance retrograde cell retention in a rat model of myocardial infarction. METHODS: Rat mesenchymal stem cells were labeled with superparamagnetic oxide nanoparticles. The magnetic responsiveness of MSCs was observed while cells flowed through a tube that served as a model of blood vessels in a 0...
2013: Stem Cell Research & Therapy
Zheyong Huang, Yunli Shen, Ning Pei, Aijun Sun, Jianfeng Xu, Yanan Song, Gangyong Huang, Xiaoning Sun, Shuning Zhang, Qing Qin, Hongming Zhu, Shan Yang, Xiangdong Yang, Yunzeng Zou, Juying Qian, Junbo Ge
Magnetic targeting has been recently introduced to enhance cell retention in animals with acute myocardial infarction. However, it is unclear whether the magnetic accumulation of intravascular cells increases the risk of coronary embolism. Upon finite element analysis, we found that the permanent magnetic field was nonuniform, manifestated as attenuation along the vertical axis and polarisation along the horizontal axis. In the in vitro experiments, iron-labelled mesenchymal stem cells (MSCs) were accumulated in layers predominantly at the edge of the magnet...
December 2013: Biomaterials
Feiyan Chen, Jun Xia, Siqun Wang, Yibing Wei, Jianguo Wu, Gangyong Huang, Jie Chen, Jingsheng Shi
BACKGROUND: The purpose of this study was to investigate the clinical efficacy of extended resection with osteotomy, fenestration and conservation of muscle (tendon) insertion in the treatment of bone tumors. METHODS: A total of 15 patients with locally aggressive bone tumors (Enneking stage II) in the adjacent muscle (tendon) insertion of the proximal extremity were enrolled in the present study (mean age of 29 years). Extended curettage of lesions with osteotomy, fenestration and/or conservation of muscle (tendon) insertion and internal fixation with a bone graft or bone cement was performed at stage I...
2013: World Journal of Surgical Oncology
Feiyan Chen, Jun Xia, Yibing Wei, Siqun Wang, Jianguo Wu, Gangyong Huang, Jie Chen, Jingsheng Shi
Wide en bloc excision of proximal ulna sections is used to treat traumatic and pathological fractures of the ulna, though poor standardization of clinical treatment often results in long-term failure of such reconstructed biomechanical structures. In order to provide insight into effective ulnar reconstructive treatments, the case of an 80-year-old Chinese Han male presenting with pathological fracture caused by a proximal ulnar metastatic tumor concurrent with metastatic renal cancer complicated by occurrence in the brain and lungs is reported and contrasted with alternative treatment techniques...
2012: European Journal of Medical Research
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