Shuzhan Wen, Xin Huang, Jingchun Ma, Guanglei Zhao, Tiancong Ma, Kangming Chen, Gangyong Huang, Jie Chen, Jingsheng Shi, Siqun Wang
Osteoarthritis (OA) is the most common degenerative disease of the joint with irreversible cartilage damage as the main pathological feature. With the development of regenerative medicine, mesenchymal stem cells (MSCs) have been found to have strong therapeutic potential. However, intraarticular MSCs injection therapy is limited by economic costs and ethics. Exosomes derived from MSC (MSC-Exos), as the important intercellular communication mode of MSCs, contain nucleic acid, proteins, lipids, microRNAs, and other biologically active substances...
2024: Frontiers in Bioengineering and Biotechnology