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https://www.readbyqxmd.com/read/29031144/senegenin-exerts-anti-depression-effect-in-mice-induced-by-chronic-un-predictable-mild-stress-via-inhibition-of-nf-%C3%AE%C2%BAb-regulating-nlrp3-signal-pathway
#1
Hongwei Li, Shiyi Lin, Tingting Qin, Hongyan Li, Zhanqiang Ma, Shiping Ma
Depressive disorder is a kind of affective disturbance disease. Emerging evidence has suggested that inflammation may contribute to the pathologic process of depressive disorder. Senegenin (SEN), a major bioactive constituent in Polygala tenuifolia Willd, has much bioactivity including anti-inflammatory and neuroprotection effects. However, the mechanism of its anti-depressant effect in mice remains unknown. This study aimed to explore the anti-depressant effects of SEN on behavioral changes and inflammatory responses in mice induced by chronic un-predictable mild stress (CUMS)...
October 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29029362/altered-tdp-43-dependent-splicing-in-hspb8-related-distal-hereditary-motor-neuropathy-and-myofibrillar-myopathy
#2
Andrea Cortese, Matilde Laurà, Carlo Casali, Ichizo Nishino, Yukiko K Hayashi, Stefania Magri, Franco Taroni, Cristiana Stuani, Paola Saveri, Maurizio Moggio, Michela Ripolone, A Prelle, C Pisciotta, A Sagnelli, Anna Pichiecchio, Mary M Reilly, Emanuele Buratti, Davide Pareyson
INTRODUCTION: Mutations in the small heat shock protein 22 gene (HSPB8) have been associated with Charcot-Marie-Tooth type 2L, distal hereditary motor neuropathy (dHMN) type IIa and, more recently, distal myopathy/myofibrillar myopathy (MFM) with protein aggregates and TDP-43 inclusions. OBJECTIVE: To report a novel family with HSPB8 (K141E) -related dHMN/MFM and to investigate, in a patient muscle biopsy, whether the presence of protein aggregates was paralleled by altered TDP-43 function...
October 13, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29028880/semantic-memory-in-hiv-associated-neurocognitive-disorders-an-evaluation-of-the-cortical-versus-subcortical-hypothesis
#3
Savanna Tierney, Steven Paul Woods, Marizela Verduzco, Jessica Beltran, Paul J Massman, Rodrigo Hasbun
Objective: HIV-associated neurocognitive disorders (HAND) have historically been characterized as a subcortical condition that does not affect semantic memory; however, recent evidence suggests that the cortical regions that support semantic memory may be affected in HIV. Method: The current study examined the effects of HAND on semantic memory in 85 HIV+ individuals with HAND, 193 HIV+ individuals without HAND, and 181 HIV- individuals who completed the Boston Naming Test (BNT) and the Famous Faces subtest of the Kauffman Adolescent and Adult Intelligence Test (KAIT-FF)...
September 28, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29028778/essential-oils-and-gastroparesis-power-for-transforming-health-hope-and-quality-of-life
#4
Chalyce Macoskey, Dorothy J Dunn
This study explored how essential oils for persons with gastroparesis symptoms affect the quality of life. Gastroparesis is a chronic delayed gastric motility disorder characterized by postprandial fullness, early satiety, nausea, vomiting, abdominal discomfort, bloating, depression, and anxiety. The aim of this study was to determine how essential oils support digestion and eliminate inflammation in the body as evidenced by self-reporting a decrease in symptoms, thereby improving quality of life. A qualitative descriptive methodology using Barrette's Theory of Power as Knowing Participation in Change thematic framework was used...
November 2017: Holistic Nursing Practice
https://www.readbyqxmd.com/read/29028627/local-dynamic-stability-during-treadmill-walking-can-detect-children-with-developmental-coordination-disorder
#5
Merete B Speedtsberg, Sofie B Christensen, Jan Stenum, Thomas Kallemose, Jesper Bencke, Derek J Curtis, Bente R Jensen
OBJECTIVE: Developmental coordination disorder (DCD) is an innate impairment of motor coordination that affects basic locomotion and balance. This study investigated local dynamic stability of trunk accelerations during treadmill walking as an objective evaluation of gait stability and the sensitivity and specificity of this measure to discriminate children with DCD from typically developing children. METHOD: Eight children with DCD and ten age- and gender-matched typically developing children (TD) walked four minutes on a treadmill...
October 5, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29028610/systematic-review-and-meta-analysis-of-dropout-rates-in-individual-psychotherapy-for-generalized-anxiety-disorder
#6
REVIEW
Elon Gersh, David J Hallford, Simon M Rice, Nikolaos Kazantzis, Hannah Gersh, Benji Gersh, Carolyn A McCarty
BACKGROUND: Despite being a relatively prevalent and debilitating disorder, Generalized Anxiety Disorder (GAD) is the second least studied anxiety disorder and among the most difficult to treat. Dropout from psychotherapy is concerning as it is associated with poorer outcomes, leads to service inefficiencies and can disproportionately affect disadvantaged populations. No study to date has calculated a weighted mean dropout rate for GAD and explored associated correlates. METHODS: A systematic review was conducted using PsycINFO, Medline and Embase databases, identifying studies investigating individual psychotherapies for adults with GAD...
October 6, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29028582/internalized-stigma-and-its-impact-in-indian-outpatients-with-bipolar-disorder
#7
Arghya Pal, Pratap Sharan, Rakesh Kumar Chadda
Patients with many psychiatric disorders have considerable internalized stigma. The current study intended to examine the level and impact of internalized stigma in patients with bipolar affective disorder (BPAD). 60 patients with BPAD, 33 patients with schizophrenia and 30 patients with anxiety disorders were compared on Internalized Stigma of Mental Illness scale and The Stigma Scale. The patients with BPAD were assessed using Rosenberg Self-Esteem Scale (RSES), Participation scale (PS) and World Health Organization Quality Of Life - Brief Version - Hindi (WHOQOL-bref)...
October 3, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29028550/paternal-exposure-to-environmental-17-alpha-ethinylestradiol-concentrations-modifies-testicular-transcription-affecting-the-sperm-transcript-content-and-the-offspring-performance-in-zebrafish
#8
David G Valcarce, Elena Vuelta, Vanesa Robles, Maria Paz Herráez
The synthetic estrogen 17-α-ethinylestradiol (EE2), a major constituent in contraceptive pills, is an endocrine disrupting chemical (EDC) present in the aquatic environment at concentrations of ng/L. Developmental exposure to these low concentrations in fish can induce several disorders. Zebrafish (Danio rerio) is a perfect organism for monitoring the effects of environmental contaminants. Our hypothesis is that changes promoted by EE2 in the germ line of male adults could be transmitted to the unexposed progeny...
September 28, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29028500/neural-network-topology-in-adhd-evidence-for-maturational-delay-and-default-mode-network-alterations
#9
T W P Janssen, A Hillebrand, A Gouw, K Geladé, R Van Mourik, A Maras, J Oosterlaan
OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) has been associated with widespread brain abnormalities in white and grey matter, affecting not only local, but global functional networks as well. In this study, we explored these functional networks using source-reconstructed electroencephalography in ADHD and typically developing (TD) children. We expected evidence for maturational delay, with underlying abnormalities in the default mode network. METHODS: Electroencephalograms were recorded in ADHD (n=42) and TD (n=43) during rest, and functional connectivity (phase lag index) and graph (minimum spanning tree) parameters were derived...
September 23, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29028375/health-disparities-in-patients-with-pulmonary-arterial-hypertension-a-blueprint-for-action-an-official-american-thoracic-society-statement
#10
Arunabh Talwar, Joe G N Garcia, Halley Tsai, Matthew Moreno, Tim Lahm, Roham T Zamanian, Roberto Machado, Steven M Kawut, Mona Selej, Stephen Mathai, Laura Hoyt D'Anna, Sonu Sahni, Erik J Rodriquez, Richard Channick, Karen Fagan, Michael Gray, Jessica Armstrong, Josanna Rodriguez Lopez, Vinicio de Jesus Perez
BACKGROUND: Health disparities have a major impact in the quality of life and clinical care received by minorities in the United States. Pulmonary arterial hypertension (PAH) is a rare cardiopulmonary disorder that affects children and adults and that, if untreated, results in premature death. The impact of health disparities in the diagnosis, treatment, and clinical outcome of patients with PAH has not been systematically investigated. OBJECTIVES: The specific goals of this research statement were to conduct a critical review of the literature concerning health disparities in PAH, identify major research gaps and prioritize direction for future research...
October 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29028369/toll-like-receptors-significance-ligands-signaling-pathways-and-functions-in-mammals
#11
Mallenahally Kusha Vidya, V Girish Kumar, Veerasamy Sejian, Madiajagan Bagath, Govindan Krishnan, Raghavendra Bhatta
This review attempts to cover the implication of the toll-like receptors (TLRs) in controlling immune functions with emphasis on their significance, function, regulation and expression patterns. The tripartite TLRs are type I integral transmembrane receptors that are involved in recognition and conveying of pathogens to the immune system. These paralogs are located on cell surfaces or within endosomes. The TLRs are found to be functionally involved in the recognition of self and non-self-antigens, maturation of DCs and initiation of antigen-specific adaptive immune responses as they bridge the innate and adaptive immunity...
October 13, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/29028353/activated-microglia-targeting-dendrimer-minocycline-conjugate-as-therapeutics-for-neuroinflammation
#12
Rishi Sharma, Soo-Young Kim, Anjali Sharma, Zhi Zhang, Siva Pramodh Kambhampati, Sujatha Kannan, Rangaramanujam M Kannan
Brain related disorders have outmatched cancer and cardiovascular diseases worldwide as the leading cause of morbidity and mortality. The lack of effective therapies and the relatively dry central nervous system (CNS) drug pipeline pose formidable challenge. Superior, targeted delivery of current clinically approved drugs may offer significant potential. Minocycline has shown promise for the treatment of neurological diseases owing to its ability to penetrate the blood brain barrier (BBB), and potency. Despite its potential in the clinic, and in preclinical models, the high doses needed to affect a positive therapeutic response has led to side effects...
October 13, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29028242/public-mental-health
#13
Jutta Lindert, Johan Bilsen, Marija Jakubauskiene
Public mental health (PMH) is a major challenge for public health research and practice. This article is organized in six parts. First, we will highlight the significance of PMH; second, we will define mental health and mental disorders; third, we identify and describe determinants of mental health and mental disorders on which we worked in the past 10 years since the establishment of the PMH section such as social determinants and violence. Fourth, we will describe the development of the EUPHA PMH section and provide details on vulnerable groups in the field of PMH, on violence as a main determinant and on suicide as an outcome which affects all countries in the European region...
October 1, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29028149/solitary-perianal-rectal-mass-as-the-only-manifestation-of-crohn-s-disease
#14
Hu Dan Dan, Bei Tan, Jia Ming Qian
Crohn's disease (CD) is a chronic relapsing inflammatory disorder that can affect any part of the gastrointestinal tract, from mouth to anus. Bissell et al first described the regional enteritis with perianal disease in 1934(1) .
October 13, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29028088/antitumor-effect-of-mir-27b-3p-on-lung-cancer-cells-via-targeting-fzd7
#15
Y Sun, T Xu, Y-W Cao, X-Q Ding
OBJECTIVE:   Lung cancer is the most common malignancy with the highest mortality rate among cancers. microRNAs (miRNAs) have been confirmed to be closely related to the physiological disorder, especially the tumor process. This study aimed to investigate the effect of miR-27b-3p on lung tumor cells. MATERIALS AND METHODS: The expressions of miR-27b-3p in lung tumors and adjacent non-tumors lung tissues were compared. We test the bonding effect of miR-27b-3p on the Fzd7 promoter, and miR-27b-3p effects on the Fzd7 expression in both NCI-H446 and A549 cells...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29027984/the-effect-of-intra-articular-injection-of-autologous-microfragmented-fat-tissue-on-proteoglycan-synthesis-in-patients-with-knee-osteoarthritis
#16
Damir Hudetz, Igor Borić, Eduard Rod, Željko Jeleč, Andrej Radić, Trpimir Vrdoljak, Andrea Skelin, Gordan Lauc, Irena Trbojević-Akmačić, Mihovil Plečko, Ozren Polašek, Dragan Primorac
Osteoarthritis (OA) is one of the leading musculoskeletal disorders in the adult population. It is associated with cartilage damage triggered by the deterioration of the extracellular matrix tissue. The present study explores the effect of intra-articular injection of autologous microfragmented adipose tissue to host chondrocytes and cartilage proteoglycans in patients with knee OA. A prospective, non-randomized, interventional, single-center, open-label clinical trial was conducted from January 2016 to April 2017...
October 13, 2017: Genes
https://www.readbyqxmd.com/read/29027913/neural-hyperexcitability-in-autism-spectrum-disorders
#17
REVIEW
Yukari Takarae, John Sweeney
Despite the progress that has been made in research on autism spectrum disorders (ASD), the understanding of the biological basis of ASD to identify targets for novel, effective treatment remains limited. One of the leading biological theories of autism is a model of cortical hyperexcitability. While numerous genetic and epigenetic studies support this model, how this particular biological alteration relates to known phenotypes in ASD is not well established. Using examples of sensory processing alterations, this review illustrates how cortical excitability may affect neural processes to result eventually in some core clinical phenotypes in ASD...
October 13, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29027838/the-role-of-appraisal-in-dysphoric-affect-reactivity-to-positive-laboratory-films-and-daily-life-events-in-depression
#18
Vanessa Panaite, Alana Whittington, Alexandra Cowden Hindash
Hedonic deficits are linked to protracted dysphoric affect (DA) in depression, a disorder characterised by emotion context insensitivity (ECI). Recent findings from daily life studies contradict the ECI view. This study longitudinally investigated DA across laboratory and daily life contexts and the conditions associated with discrepancies in DA reactivity. Thirty-three healthy controls and 41 adults with major depressive disorder (MDD) provided responses to neutral and positive (a) films viewed in the laboratory and (b) daily events recorded over the course of three days using ecological momentary assessment (EMA) methodology...
October 13, 2017: Cognition & Emotion
https://www.readbyqxmd.com/read/29027829/mental-health-pain-symptoms-and-systemic-comorbidities-in-women-with-endometriosis-a-cross-sectional-study
#19
Silvia Vannuccini, Lucia Lazzeri, Cinzia Orlandini, Giuseppe Morgante, Giuseppe Bifulco, Andrea Fagiolini, Felice Petraglia
INTRODUCTION: Endometriosis is a gynecological disease with a severe impact on quality of life. The aim of this study is to assess mental health status in a group of women with endometriosis, investigating their clinical history, pain symptoms and systemic comorbidities. METHODS: An observational cross-sectional study was performed on a group of Italian Caucasian women with endometriosis (n = 134). All patients filled the 'Patient Health Questionnaire' (PHQ), a self-administered screening tool for mental health disorders...
October 13, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29027827/triggering-receptor-expressed-on-myeloid-cells-in-the-pathogenesis-of-periodontitis-potential-novel-treatment-strategies
#20
Courtney P Rudick, Takanari Miyamoto, Melissa S Lang, Devendra K Agrawal
Periodontal diseases are polymicrobial inflammatory disorders of the tissue, ligament, and bone structures supporting teeth. Periodontitis (inflammation with corresponding loss of attachment) affects 40-50% of adults. Recently, members of the Triggering Receptor on Myeloid Cell (TREM) family have been studied to determine their relationship to these diseases. Areas covered: TREM-1 is a receptor expressed on the surface of PMNs, monocytes, macrophages, dendritic cells, vascular smooth muscle cells, and keratinocytes upregulated in the presence of periodontal inflammation...
October 13, 2017: Expert Review of Clinical Immunology
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