keyword
MENU ▼
Read by QxMD icon Read
search

Affective disorder

keyword
https://www.readbyqxmd.com/read/29475178/progranulin-facilitates-the-increase-of-platelet-count-in-immune-thrombocytopenia
#1
Yingyi Yu, Yuanyuan Shi, Xinyi Zuo, Qi Feng, Yu Hou, Wei Tang, Yi Lu, Fan Yi, Ming Hou, Yuan Yu, Jun Peng
INTRODUCTION: Progranulin (PGRN) is emerging as a critical immune mediator involved in a variety of autoimmune disorders. However, its role in immune thrombocytopenia (ITP) remains unclear. MATERIALS AND METHODS: In this study, the enzyme-linked immunosorbent assay was used for determining the plasma levels of PGRN in ITP patients vs. healthy controls. In addition, the role of PGRN in ITP was investigated in two kinds of ITP murine models. Further, we explored whether PGRN functioned by affecting the number of T regulatory cells (Tregs) using flow cytometry...
February 17, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29475105/the-prevalence-of-posttraumatic-stress-in-adolescents-eight-years-after-the-wenchuan-earthquake
#2
Bingli Du, Xiaozhi Ma, Xiancai Ou, Ye Jin, Pengwei Ren, Jing Li
In 2008, an 8.0 Richter scale earthquake devastated Wenchuan in China, which resulted in heavy casualties, and had wide-reaching psychological effects on survivors. To examine its impact on the survivors, this study aims to investigate the prevalence of posttraumatic stress disorder (PTSD) and posttraumatic growth (PTG) in adolescents eight years after the earthquake. The cross-section survey was conducted in two different earthquake-affected areas, and data were collected from 4118 respondents. Instruments included the questionnaire on demographic information, the questionnaire on seismic exposure, PTSD Checklist-Civilian Version (PCL-C) questionnaire, Posttraumatic Growth Inventory (PTGI), Perceived Social Support Scale (PSSS) and Simple Coping Style Questionnaire (SCSQ)...
February 5, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29475017/anxiolytic-effects-of-ascorbic-acid-and-ketamine-in-mice
#3
Daiane B Fraga, Gislaine Olescowicz, Morgana Moretti, Aline Siteneski, Mauren K Tavares, Dayane Azevedo, André R S Colla, Ana Lúcia S Rodrigues
Some studies have demonstrated that ascorbic acid, similarly to ketamine, exhibits antidepressant-like effects mediated, at least in part, by modulation of the glutamatergic system. Despite the involvement of glutamatergic system in the pathophysiology of anxiety disorders, the ability of ascorbic acid and ketamine to elicit anxiolytic effects in animal models remains to be established. Therefore, this study investigated the effects of a single administration of ascorbic acid, ketamine or diazepam (positive control) in different animal models of anxiety...
February 13, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29475011/the-cranky-thermometers-visual-analogue-scales-measuring-irritability-in-youth
#4
Glenn A Melvin, Bruce J Tonge, Melissa Mulraney, Michael Gordon, John Taffe, Ester Klimkeit
This study assessed the psychometric properties of two visual analogue scales of irritability, known as the Cranky Thermometers (CT), in both an Australian community secondary-school sample (N = 164) and a sample of adolescents with a depressive disorder (N = 127). The first scale Cranky Now measures current irritability, and the second, Cranky Two Weeks, measures peak irritability within the last two weeks. CT scores were significantly higher in adolescents with major depressive disorder than in the school sample and showed improvement following treatment for depression...
February 20, 2018: Journal of Adolescence
https://www.readbyqxmd.com/read/29474954/orexin-1-and-orexin-2-receptor-antagonism-in-the-basolateral-amygdala-modulate-long-term-potentiation-of-the-population-spike-in-the-perforant-path-dentate-gyrus-evoked-field-potential-in-rats
#5
Motahareh Rouhi Ardeshiri, Narges Hosseinmardi, Esmaeil Akbari
Involvement of amygdalo-hippocampal substructures in patients with narcolepsy due to deficiencies in the orexinergic system, and the presence of hippocampus-dependent memory impairments in this disorder, have led us to investigate the effects of orexin 1 and 2 receptor antagonism in the basolateral amygdala (BLA) on long-term potentiation (LTP) of dentate gyrus (DG) granular cells. We used a 200-Hz high-frequency stimulation protocol in anesthetized rats. We studied the long-term synaptic plasticity of perforant path-dentate gyrus granule cells following the inactivation of orexin receptors before and after tetanic stimulation...
February 20, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29474844/cardiac-output-in-pre-eclampsia-is-associated-with-the-presence-of-fetal-growth-restriction-not-gestation-at-onset-a-prospective-cohort-study
#6
Jasmine Tay, Lin Foo, Giulia Masini, Phillip R Bennett, Carmel M Mceniery, Ian B Wilkinson, Christoph C Lees
BACKGROUND AND OBJECTIVES: Pre-eclampsia (PE) and fetal growth restriction (FGR) are considered to be placentally-mediated disorders. The clinical manifestations are widely held to relate to gestation age at onset with early- and late-onset PE considered to be phenotypically distinct. Recent studies have reported conflicting findings in relation to cardiovascular function, and in particular cardiac output, in PE and FGR. STUDY DESIGN: We investigated maternal cardiovascular function in relation to clinical subtype in 45 pathological pregnancies (14 'PE only', 16 'FGR only', 15 'PE and FGR') and compared these with 107 healthy person observations...
February 20, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29474555/health-related-quality-of-life-of-patients-after-surgery-for-acute-type-a-aortic-dissection
#7
Uyanga Adam, Helmut Habazettl, Katharina Graefe, Hermann Kuppe, Maximilian Wundram, Stephan Dominik Kurz
OBJECTIVES: Acute Type A aortic dissection (ATAAD) and the ensuing surgical therapy may be experienced as a traumatic event by patients. This study aimed at analysing the prevalence of post-traumatic stress disorder (PTSD) and the physical and mental well-being of survivors of surgically treated ATAAD. METHODS: A total of 393 survivors were contacted and asked to fill in various health questionnaires. RESULTS: Two hundred and ten (53%) patients returned the questionnaires...
February 20, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29474207/health-related-fitness-in-preschool-children-with-and-without-motor-delays
#8
Sara King-Dowling, Christine Rodriguez, Cheryl Missiuna, Brian W Timmons, John Cairney
PURPOSE: School-age children with Developmental Coordination Disorder (DCD) have poor health-related fitness (HRF), but little is known about when these deficits emerge. The purpose of this study was to determine if 4- and 5-year old children who meet the criteria for DCD exhibit poorer HRF than typically developing (TD) children, and if this relationship is mediated by vigorous physical activity (VPA) engagement. METHODS: Five-hundred and ninety-two children participated (age 5...
February 23, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29474070/molecular-mechanism-dynamics-and-energetics-of-protein-mediated-dinucleotide-flipping-in-a-mismatched-dna-a-computational-study-of-rad4-dna-complex
#9
Kartheek Pitta, Marimuthu Krishnan
DNA damages alter genetic information and adversely affect gene expression pathways leading to various complex genetic disorders and cancers. DNA repair proteins recognize and rectify DNA damages with high fidelity. A critical molecular event that occurs during most protein-mediated DNA repair processes is the extrusion of orphaned bases at the damaged site facilitated by specific repairing enzymes. The molecular-level understanding of the mechanism, dynamics, and energetics of base extrusion is necessary to elucidate the molecular basis of protein-mediated DNA damage repair...
February 23, 2018: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29473907/pharmacological-inhibition-of-protein-kinase-c-reduces-west-nile-virus-replication
#10
Ana B Blázquez, Ángela Vázquez-Calvo, Miguel A Martín-Acebes, Juan-Carlos Saiz
Flaviviruses are relevant animal and human pathogens that include West Nile virus (WNV), Japanese encephalitis virus, dengue virus, or Zika virus, among others. Currently, no licensed therapy is available to fight flaviviral infections. Protein kinases C (PKCs) constitute a family of multifunctional lipid-dependent isoenzymes that regulate a wide variety of cellular processes (apoptosis, differentiation, proliferation, cellular transformation, motility, adhesion, etc.) being currently considered at the front line of drug development for the treatment of diverse human disorders...
February 23, 2018: Viruses
https://www.readbyqxmd.com/read/29473778/assessment-of-the-praxis-circuit-in-glioma-surgery-to-reduce-the-incidence-of-postoperative-and-long-term-apraxia-a-new-intraoperative-test
#11
Marco Rossi, Luca Fornia, Guglielmo Puglisi, Antonella Leonetti, Gianmarco Zuccon, Enrica Fava, Daniela Milani, Alessandra Casarotti, Marco Riva, Federico Pessina, Gabriella Cerri, Lorenzo Bello
OBJECTIVE Apraxia is a cognitive-motor deficit affecting the execution of skilled movements, termed praxis gestures, in the absence of primary sensory or motor disorders. In patients affected by stroke, apraxia is associated with lesions of the lateral parietofrontal stream, connecting the posterior parietal areas with the ventrolateral premotor area and subserving sensory-motor integration for the hand movements. In the neurosurgical literature to date, there are few reports regarding the incidence of apraxia after glioma surgery...
February 23, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29473691/assessing-cognitive-dysfunction-in-parkinson-s-disease-an-online-tool-to-detect-visuo-perceptual-deficits
#12
Rimona S Weil, Dietrich S Schwarzkopf, Bahador Bahrami, Stephen M Fleming, Ben M Jackson, Tristam J C Goch, Ayse P Saygin, Luke E Miller, Katerina Pappa, Ivanna Pavisic, Rachel N Schade, Alastair J Noyce, Sebastian J Crutch, Aidan G O'Keeffe, Anette E Schrag, Huw R Morris
BACKGROUND: People with Parkinson's disease (PD) who develop visuo-perceptual deficits are at higher risk of dementia, but we lack tests that detect subtle visuo-perceptual deficits and can be performed by untrained personnel. Hallucinations are associated with cognitive impairment and typically involve perception of complex objects. Changes in object perception may therefore be a sensitive marker of visuo-perceptual deficits in PD. OBJECTIVE: We developed an online platform to test visuo-perceptual function...
February 23, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29473661/facial-emotion-recognition-in-parkinson-s-disease-a-review-and-new-hypotheses
#13
REVIEW
Soizic Argaud, Marc Vérin, Paul Sauleau, Didier Grandjean
Parkinson's disease is a neurodegenerative disorder classically characterized by motor symptoms. Among them, hypomimia affects facial expressiveness and social communication and has a highly negative impact on patients' and relatives' quality of life. Patients also frequently experience nonmotor symptoms, including emotional-processing impairments, leading to difficulty in recognizing emotions from faces. Aside from its theoretical importance, understanding the disruption of facial emotion recognition in PD is crucial for improving quality of life for both patients and caregivers, as this impairment is associated with heightened interpersonal difficulties...
February 23, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29473532/the-promising-pharmacological-effects-and-therapeutic-medicinal-applications-of-punica-granatum-l-pomegranate-as-a-functional-food-in-humans-and-animals
#14
Kuldeep Dhama
BACKGROUND: Punica granatum L (pomegranate), is a shrub mostly available in the Mediterranean Sea region. The fruits have gained the substantial attention among researchers due to its promising biological activities including anti-inflammatory, antibacterial, antidiarrheal, immune modulatory, antitumor, wound healing and antifungal that have been attributed to various constituents of seeds, bark, juice, pericarp and leaf of this tree across the globe. The phenolic compounds of pomegranate have been documented to possess numbers of prophylactic and therapeutic utilities against various pathological infections as well as non-infectious disorders...
February 21, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29473262/local-functional-connectivity-suggests-functional-immaturity-in-children-with-attention-deficit-hyperactivity-disorder
#15
Luis Marcos-Vidal, Magdalena Martínez-García, Clara Pretus, David Garcia-Garcia, Kenia Martínez, Joost Janssen, Oscar Vilarroya, Francisco X Castellanos, Manuel Desco, Jorge Sepulcre, Susanna Carmona
Previous studies have associated Attention-Deficit/Hyperactivity Disorder (ADHD) with a maturational lag of brain functional networks. Functional connectivity of the human brain changes from primarily local to more distant connectivity patterns during typical development. Under the maturational lag hypothesis, we expect children with ADHD to exhibit increased local connectivity and decreased distant connectivity compared with neurotypically developing (ND) children. We applied a graph-theory method to compute local and distant connectivity levels and cross-sectionally compared them in a sample of 120 children with ADHD and 120 age-matched ND children (age range = 7-17 years)...
February 22, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29473194/radiographic-measurements-of-the-hindlimbs-in-crab-eating-foxes-cerdocyon-thous-linnaeus-1766
#16
M S Castilho, S C Rahal, M J Mamprim, L R Inamassu, A Melchert, F S Agostinho, L R Mesquita, R H F Teixeira, C R Teixeira
Life expectancy of crab-eating foxes in captivity is approximately 11 years, which favours the development of diseases including orthopaedic disorders. However, to understand disorders that may affect these animals, it is worth determining a normal range of measurements. Therefore, this study aimed to evaluate radiographic measurements of joint angles of the hindlimbs and the ratio of patellar ligament length to patellar length in healthy crab-eating foxes. Fifteen captive crab-eating foxes (Cerdocyon thous), eight males and seven females, aged more than 1 year old, weighing 5...
February 22, 2018: Anatomia, Histologia, Embryologia
https://www.readbyqxmd.com/read/29472954/evaluation-of-the-effectiveness-of-the-friends-for-life-program-on-children-s-anxiety-and-depression
#17
Fatemeh Moharreri, Aazam-Sadat Heydari Yazdi
Objective: Anxiety disorders and depression during childhood and adolescence are among highly prevalent serious mental health problems, which lead to reduced performance in children and can also negatively affect children's emotional and social long-term development. This study, which was conducted in Mashhad in 2015, aimed at evaluating the effectiveness of the Friends for Life cognitive-behavioral program in reducing the symptoms of anxiety and depression in children. Method: In this controlled clinical trial, 248 male students aged 10 were screened for mild to moderate symptoms of anxiety and depression using the Revised Children's Manifest Anxiety (RCMA) and the Children's Depression Inventory (CDI)...
October 2017: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/29472949/the-relationship-between-motor-imitation-and-early-social-communication-skills-in-children-with-autism
#18
Hooshang Dadgar, Javad Alaghband Rad, Zahra Soleymani, Anahita Khorammi, Joe McCleery, Saman Maroufizadeh
Objective: Development of early social skills in children is a complex process. To understand this process, it is important to assess how strengths or weaknesses in other developmental domains may be affected by these skills. The present study aimed at investigating the association of motor skills and imitation ability with early social communication skills in children with autism spectrum disorder (ASD). Method: In this study, 20 children with ASD aged 3 to 5 years (M = 4.05, SD = 0.55) participated. All children were diagnosed as ASD based on the DSM-V criteria by an independent child psychiatrist...
October 2017: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/29472931/dendritic-cell-migration-to-skin-draining-lymph-nodes-is-controlled-by-dermatan-sulfate-and-determines-adaptive-immunity-magnitude
#19
Reza Nadafi, Jasper J Koning, Henrike Veninga, Xanthi N Stachtea, Tanja Konijn, Antonie Zwiers, Anders Malmström, Joke M M den Haan, Reina E Mebius, Marco Maccarana, Rogier M Reijmers
For full activation of naïve adaptive lymphocytes in skin-draining lymph nodes (LNs), presentation of peptide:MHC complexes by LN-resident and skin-derived dendritic cells (DCs) that encountered antigens (Ags) is an absolute prerequisite. To get to the nearest draining LN upon intradermal immunization, DCs need to migrate from the infection site to the afferent lymphatics, which can only be reached by traversing a collagen-dense network located in the dermis of the skin through the activity of proteolytic enzymes...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29472852/it-is-not-just-in-faces-processing-of-emotion-and-intention-from-biological-motion-in-psychiatric-disorders
#20
REVIEW
Łukasz Okruszek
Social neuroscience offers a wide range of techniques that may be applied to study the social cognitive deficits that may underlie reduced social functioning-a common feature across many psychiatric disorders. At the same time, a significant proportion of research in this area has been conducted using paradigms that utilize static displays of faces or eyes. The use of point-light displays (PLDs) offers a viable alternative for studying recognition of emotion or intention inference while minimizing the amount of information presented to participants...
2018: Frontiers in Human Neuroscience
keyword
keyword
54303
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"