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https://www.readbyqxmd.com/read/29931542/inflammatory-features-including-symptoms-increased-serum-interleukin-6-and-c-reactive-protein-in-igg4-related-vascular-diseases
#1
Satomi Kasashima, Atsuhiro Kawashima, Fuminori Kasashima, Masamitsu Endo, Yasushi Matsumoto, Kengo Kawakami
Immunoglobulin (IgG) 4-related diseases (IgG4-RDs) are fibro-inflammatory conditions characterized by tumorous swelling and serum IgG4 levels. Intrapelvic IgG4-RD has been subclassified according to the localization site and aortic shape as IgG4-related aortic aneurysms (IgG4-AAs), periaortitis (IgG4-PA), and retroperitoneal fibrosis (IgG4-RF). The IgG4-AA pathogenesis would involve interleukin (IL)-6 upregulation, and Th2-predominant and Treg-activated immune conditions. We characterized the features of intrapelvic IgG4-RD lesions, including presence of vascular lesions...
June 21, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29931295/prognostic-factors-of-non-ampullary-duodenal-adenocarcinoma
#2
Teijiro Hirashita, Masayuki Ohta, Kazuhiro Tada, Kunihiro Saga, Hiroomi Takayama, Yuichi Endo, Hiroki Uchida, Yukio Iwashita, Masafumi Inomata
Background: Non-ampullary duodenal adenocarcinoma, excluding carcinoma in the ampulla of Vater, is a rare disease. Although several prognostic factors have been reported, they remain controversial due to the rarity of non-ampullary duodenal adenocarcinoma. The aims of this study were to investigate prognostic factors in patients with non-ampullary duodenal adenocarcinoma and to assess chemotherapy in patients with recurrence. Patients and methods: Records of 25 patients who underwent surgical treatment for non-ampullary duodenal adenocarcinoma from 2004 to 2016 were retrospectively reviewed...
June 19, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29908693/collapsing-glomerulopathy-in-lambda-light-chain-amyloidosis-a-report-of-2-cases
#3
Mazdak A Khalighi, Alexander J Gallan, Anthony Chang, Shane M Meehan
Amyloid nephropathy is an uncommon disease that frequently presents with reduced kidney function and proteinuria and, in developed nations, is most often associated with underlying paraproteinemia. The histologic appearance of glomerular amyloid deposition includes mesangial and capillary wall infiltration by an amorphous eosinophilic material, and features of endo- or extracapillary proliferation are not typically seen. Rare cases of crescentic injury have been reported in a subset of patients with amyloid nephropathy, particularly those with amyloid derived from serum amyloid A protein...
June 13, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29846579/establishment-of-a-novel-scoring-system-for-colon-capsule-endoscopy-to-assess-the-severity-of-ulcerative-colitis-capsule-scoring-of-ulcerative-colitis
#4
Naoki Hosoe, Masaru Nakano, Ken Takeuchi, Yutaka Endo, Katsuyoshi Matsuoka, Takayuki Abe, Teppei Omori, Mari Hayashida, Taku Kobayashi, Atsushi Yoshida, Shinta Mizuno, Nakazato Yoshihiro, Makoto Naganuma, Takanori Kanai, Mamoru Watanabe, Fumiaki Ueno, Yasuo Suzuki, Toshifumi Hibi, Haruhiko Ogata
Background: The usefulness of second-generation colon capsule endoscopy (CCE-2) for ulcerative colitis (UC) has not been fully demonstrated. This study aimed to develop an endoscopic severity score of UC for CCE-2. Methods: Patients diagnosed with UC were enrolled prospectively and underwent colonoscopy and CCE-2 on the same day. The collected CCE-2 videos were adopted for the development of the score. These videos were scored by 4 blinded inflammatory bowel disease experts...
May 26, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29731883/evidence-for-critical-role-of-tie2-ang1-interaction-in-metastatic-oral-cancer
#5
Daisuke Kitajima, Atsushi Kasamatsu, Dai Nakashima, Isao Miyamoto, Yasushi Kimura, Yosuke Endo-Sakamoto, Masashi Shiiba, Hideki Tanzawa, Katsuhiro Uzawa
Angiopoietin-1 (Ang1) is a binding partner of endothelial cell-specific tyrosine-protein kinase receptor (Tie2), which serves important roles in vascular development and angiogenesis. Tie2 is closely associated with the metastasis of oral squamous cell carcinomas (OSCCs) however, little is known about the correlation between Tie2 and Ang1. In the present study, the functional mechanisms of the Tie2/Ang1 interaction were investigated using Tie2 overexpressed (oeTie2) OSCC cells and recombinant Ang1 protein. oeTie2 cells had increased cell-cell and cell-extracellular matrix adhesions compared with the control cells...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29701340/comparaison-between-endovascular-approach-and-aorto-bifemoral-bypass-for-tasc-d-aorto-iliac-disease-patients-treated-between-2011-2017
#6
Joel Sousa, João Neves, André Ferreira, José Vidoedo, José Teixeira
INTRODUCTION: In the last few years, endovascular approaches have been demonstrating remarkable results on the treatment of aortoiliac TASC D lesions. However, the results remain conflictuous and proper evidence regarding the best treatment option for this group of patients is still lacking. Through this work, we aim to compare patency, cost-effectiveness and quality of life in patients successfully treated by these two approaches. METHODS: Patients with TASC D aorto-iliac disease, from two independent Vascular Surgery Centers, treated either by open surgery and endovascular intervention between 2011- 2017, were retrospectively analyzed and consecutively included (n=59)...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29692722/the-deletion-of-endothelial-sodium-channel-%C3%AE-%C3%AE-enac-impairs-endothelium-dependent-vasodilation-and-endothelial-barrier-integrity-in-endotoxemia-in-vivo
#7
Magdalena Sternak, Anna Bar, Mateusz G Adamski, Tasnim Mohaissen, Brygida Marczyk, Anna Kieronska, Marta Stojak, Kamil Kus, Antoine Tarjus, Frederic Jaisser, Stefan Chlopicki
The role of epithelial sodium channel (ENaC) activity in the regulation of endothelial function is not clear. Here, we analyze the role of ENaC in the regulation of endothelium-dependent vasodilation and endothelial permeability in vivo in mice with conditional αENaC subunit gene inactivation in the endothelium (endo-αENaCKO mice) using unique MRI-based analysis of acetylcholine-, flow-mediated dilation and vascular permeability. Mice were challenged or not with lipopolysaccharide (LPS, from Salmonella typhosa , 10 mg/kg, i...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29682110/igg4-related-arterial-disease
#8
REVIEW
Fuminori Kasashima, Kengo Kawakami, Yasushi Matsumoto, Masamitsu Endo, Satomi Kasashima, Atsuhiro Kawashima
Immunoglobulin G4-related diseases (IgG4-RD) are systemic inflammatory conditions, characterized by high serum IgG4 concentrations, and pathologically IgG4-positive plasmacytes infiltrations and storiform fibrosis. We described IgG4-related inflammatory abdominal aortic aneurysm in 2008, and revealed the existence of vascular lesions. IgG4-related vascular lesions frequently occur in the aorta and branching medium-sized arteries with or without aneurysmal change. The inflammatory lesion mainly involves in the adventitia, indicating remarkable adventitial fibrous thickening with infiltration of inflammatory cells...
March 25, 2018: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29610557/dietary-intake-of-inorganic-phosphorus-has-a-stronger-influence-on-vascular-endothelium-function-than-organic-phosphorus
#9
Hiromi Kawamura, Sarasa Tanaka, Yuri Ota, Sumire Endo, Mariko Tani, Midori Ishitani, Motoyoshi Sakaue, Mikiko Ito
Phosphorus management through dietetic therapy is vital for the prevention of cardiovascular disease in chronic kidney disease patients. There are two main sources of phosphorus in the diet, organic phosphorus from protein and inorganic phosphorus from food additives. The adverse effects of high phosphorus intake on vascular-endothelium function have been reported; however, the differences in the effects of organic phosphorus versus inorganic phosphorus are not clear. In this study, we examined an acute effect of these high phosphorus meals intake on vascular-endothelium function...
March 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/29610036/paradoxical-association-of-symptomatic-local-vasogenic-edema-with-global-cerebral-hypoperfusion-after-direct-revascularization-surgery-for-adult-moyamoya-disease
#10
Ryosuke Tashiro, Miki Fujimura, Shunji Mugikura, Kuniyasu Niizuma, Hidenori Endo, Toshiki Endo, Teiji Tominaga
BACKGROUND: Superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis is the standard treatment for Moyamoya disease (MMD). Cerebral hyperperfusion syndrome is a potential complication of this procedure and can cause local vasogenic edema and/or delayed intracerebral hemorrhage. Cerebral hypoperfusion is a contradictory postoperative pathophysiological condition implicated in MMD, but its association with symptomatic local vasogenic edema has not been reported. CASE REPORT: A 31-year-old woman with MMD underwent left STA-MCA anastomosis 3 months after a minor completed stroke in bilateral hemispheres...
March 30, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29573275/a-role-for-alf4-during-gall-and-giant-cell-development-in-the-biotic-interaction-between-arabidopsis-and-meloidogyne-spp
#11
Rocio Olmo, Javier Cabrera, Carmen Fenoll, Carolina Escobar
Root-knot nematodes (RKNs; Meloidogyne spp.) are a major pest for the agriculture worldwide. RKNs induce specialized feeding cells (giant cells; GCs) inside galls which are de novo formed pseudo-organs in the roots that share similarities with other developmental processes as lateral root (LR) and callus formation or grafting involving new vascular development or pericycle proliferation. Hence, it is pertinent to study the molecular mechanisms directing the plant-nematode interaction. In this respect, ALF4 is a key gene during lateral root (LR) formation, vascular vessels reconnection in grafting, hormone-induced callus formation or de novo root organogenesis from leaf explants...
March 24, 2018: Physiologia Plantarum
https://www.readbyqxmd.com/read/29553089/is-trisomy-21-a-risk-factor-for-rapid-progression-of-pulmonary-arteriopathy-revisiting-histopathological-characteristics-using-282-lung-biopsy-specimens
#12
Naoki Masaki, Yuriko Saiki, Masato Endo, Kay Maeda, Osamu Adachi, Masatoshi Akiyama, Shunsuke Kawamoto, Yoshikatsu Saiki
BACKGROUND: Pulmonary hypertension (PH) is more progressive in trisomy 21 patients. However, pulmonary arteriopathic lesions in these patients have not been fully characterized histopathologically.Methods and Results:A retrospective review of a lung biopsy registry identified 282 patients: 188 patients with trisomy 21 (Group D) and 94 without (Group N). The mean age at lung biopsy was 3 and 7 months (P<0.0001). Pulmonary arterial pressure (PAP) and pulmonary vascular resistance were similar between the 2 groups...
March 16, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29548823/arginase-controls-soluble-vascular-endothelial-growth-factor-receptor-1-sflt1-to-maintain-pregnancy-homeostasis
#13
Hiroko Tanaka, Keiichi Kumasawa, Aiko Kakigano, Kazuya Mimura, Masayuki Endo, Takuji Tomimatsu, Tadashi Kimura
Excessive soluble fms-like tyrosine kinase-1 (sFlt-1) has been strongly implicated in preeclampsia. An increase in the serum sFlt-1 level occurs before the onset of preeclampsia, and the sFlt-1 level is already higher in women who are predisposed to preeclampsia than in normotensive pregnant women. This study aimed to investigate the relation between arginase and sFlt-1 in the plasma of preeclamptic women and normotensive pregnant women. We suggested that a regulatory mechanism exists that suppresses the level of sFlt-1...
May 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29546793/resection-of-puncture-site-necrosis-over-an-arteriovenous-fistula-endoclamp-use-for-preservation-of-cannulation-sites
#14
Alexandros Mallios, William Jennings, Benoit Boura, Alessandro Costanzo, Myriam Combes
Skin necrosis overlying an arteriovenous fistula at the cannulation site is a common and potentially life-threatening problem, often associated with underlying aneurysm formation. Arteriovenous fistula-skin necrosis generally requires resection of surrounding skin margins and the underlying aneurysmal vessel wall, allowing repair with healthy tissue of the arteriovenous fistula in addition to closure of soft tissue and skin. In patients with insufficient fistula length, salvage of these arteriovenous fistulas may result in difficult or insurmountable cannulation issues leading to attempts at one-needle cannulation dialysis or, most often, catheter placement...
May 2018: Journal of Vascular Access
https://www.readbyqxmd.com/read/29527330/etv2-mediates-endothelial-transdifferentiation-of-glioblastoma
#15
Chengjian Zhao, Gustavo A Gomez, Yuwei Zhao, Yu Yang, Dan Cao, Jing Lu, Hanshuo Yang, Shuo Lin
Glioblastoma multiforme (GBM) is characterized by extensive endothelial hyperplasia. Recent studies suggest that a subpopulation of endothelial cells originates via vasculogenesis by the transdifferentiation of GBM tumor cells into endothelial cells (endo-transdifferentiation). The molecular mechanism underlying this process remains poorly defined. Here, we show that the expression of ETS variant 2 (ETV2), a master regulator of endothelial cell development, is highly correlated with malignancy. Functional studies demonstrate that ETV2 is sufficient and necessary for the transdifferentiation of a subpopulation of CD133+/Nestin+ GBM/neural stem cells to an endothelial lineage...
2018: Signal Transduction and Targeted Therapy
https://www.readbyqxmd.com/read/29486231/recent-trends-in-publications-of-us-and-european-directors-in-vascular-surgery
#16
Afsha Aurshina, Anil Hingorani, Amrit Hingorani, Natalie Marks, Enrico Ascher
BACKGROUND: We hypothesized that there may be significant differences between academic productivity of the vascular training programs in the United States (US) and Europe. In an effort to explore this theory, we reviewed the number of vascular publications listed in PubMed from 2010 to 2015 for US and European directors in vascular surgery. METHODS: The list of program directors from the Association of Program Directors in Vascular Surgery (APDVS) and the European Union of Medical Specialists (EUMS) were queried for the names of the directors of vascular surgical training programs at the end of 2015...
February 24, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29484444/autophagy%C3%A2-mediated-adaptation-of-hepatocellular-carcinoma-cells-to-hypoxia%C3%A2-mimicking-conditions-constitutes-an-attractive-therapeutic-target
#17
Satoshi Owada, Hitoshi Endo, Yukari Shida, Chisa Okada, Kanako Ito, Takahiro Nezu, Masayuki Tatemichi
Hepatocellular carcinoma has extremely poor prognosis. In cancerous liver tissues, aberrant proliferation of cancer cells leads to the creation of an area where an immature vascular network is formed. Since oxygen is supplied to cancer tissues through the bloodstream, a part of the tumor is exposed to hypoxic conditions. As hypoxia is known to severely reduce the effectiveness of existing anticancer agents, novel valid therapeutic targets must be identified for the treatment of hepatocellular carcinoma. Generally, autophagy has been reported to play an important role in the adaptation of cancer cells to hypoxia...
April 2018: Oncology Reports
https://www.readbyqxmd.com/read/29479417/the-role-of-tevar-in-the-management-of-a-recurrent-aorto-gastric-fistula
#18
Terri-Ann T Russell, Pranitha Pinnamaraju, Maher Hamish
An aorto-gastric fistula is a catastrophic and rare cause of an upper gastrointestinal bleed. The diagnosis requires a high index of suspicion and expedient management as any delay in each of these component, will be to the detriment of the patient. We report a case of a patient with two episodes of this rare event, with haemodynamic compromise, 15 years after having had a trans-hiatal oesophagectomy for an adenocarcinoma of the oesophagus who presented on both occasions. He had thoracic endo-vascular aortic repair (TEVAR) on both presentations and survived...
February 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29467541/inhibition-of-endo-lysosomal-function-exacerbates-vascular-calcification
#19
Yujun Cai, Xue-Lin Wang, Alyssa M Flores, Tonghui Lin, Raul J Guzman
Vascular calcification is a pathologic response to mineral imbalances and is prevalent in atherosclerosis, diabetes mellitus, and chronic kidney disease. When located in the media, it is highly associated with increased cardiovascular morbidity and mortality, particularly in patients on dialysis. Vascular calcification is tightly regulated and controlled by a series of endogenous factors. In the present study, we assess the effects of lysosomal and endosomal inhibition on calcification in vascular smooth muscle cells (VSMCs) and aortic rings...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29459015/endovascular-interventions-decrease-length-of-hospitalization-and-are-cost-effective-in-acute-mesenteric-ischemia
#20
Young Erben, Clinton D Protack, Raymond A Jean, Brandon J Sumpio, Samuel M Miller, Shirley Liu, Gerardo Trejo, Bauer E Sumpio
OBJECTIVE: Acute mesenteric ischemia (AMI) continues to be one of the most devastating diagnoses requiring emergent vascular intervention. There is a national trend toward increased use of endovascular procedures, with improved survival for the treatment of these patients. Our aim was to evaluate whether this trend has changed the treatment of AMI and the subsequent impact on length of hospitalization and hospitalization costs. METHODS: We identified all patients admitted for AMI from the National Inpatient Sample from 2004 to 2014 who received open surgical revascularization (OPEN) or an endovascular intervention (ENDO)...
February 16, 2018: Journal of Vascular Surgery
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