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https://www.readbyqxmd.com/read/27893420/prognostic-value-of-three-dimensional-echocardiographic-right-ventricular-ejection-fraction-in-patients-with-pulmonary-arterial-hypertension
#1
Mitsushige Murata, Toshimitsu Tsugu, Takashi Kawakami, Masaharu Kataoka, Yugo Minakata, Jin Endo, Hikaru Tsuruta, Yuji Itabashi, Yuichiro Maekawa, Mitsuru Murata, Keiichi Fukuda
BACKGROUND: Right ventricular (RV) function is an independent predictor of clinical outcomes in patients with pulmonary arterial hypertension (PAH). However, it remains controversial which RV parameter should be measured as an appropriate index for the treatment of PAH. The aim of this study was to identify the most useful parameter that correlates with hemodynamics and predicts clinical outcomes in PAH. RESULTS: Most of the clinical and echocardiographic RV parameters were significantly correlated with pulmonary vascular resistance (PVR) as well as mean pulmonary arterial pressure (mPAP)...
November 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27866570/the-diagnosis-and-treatment-of-peripheral-arterial-vascular-disease
#2
Holger Lawall, Peter Huppert, Christine Espinola-Klein, Gerhard Rümenapf
BACKGROUND: In peripheral arterial occlusive disease (PAOD), arterial stenosis or occlusion impairs perfusion in the territory of the distal portion of the aorta and the iliac and leg arteries. In Germany, the prevalence of PAOD rises with age, reaching 20% among persons over age 70. METHODS: This guideline was prepared by a collaboration of 22 medical specialty societies and two patient self-help organizations on the basis of pertinent publications that were retrieved by a systematic search in PubMed for articles that appeared from 2008 to April 2014, with a subsequent update to May 2015...
October 28, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/27836897/positive-versus-negative-effects-of-vegf165-on-ca2-signaling-and-no-production-in-human-endothelial-cells
#3
Derek S Boeldt, Jennifer Krupp, Fu-Xian Yi, Nauman Khurshid, Dinesh M Shah, Ian M Bird
The role increased vascular endothelial growth factor (VEGF) plays in vascular function during normal vs preeclamptic pregnancy has been a source of some controversy of late. In this study we seek to understand how VEGF165 influences vasodilator production via Ca(2+) signaling mechanisms in human endothelial cells. We utilize human umbilical vein endothelial cells (HUVEC) as well as intact ex vivo human umbilical vein (HUV Endo) to address direct stimulation of Ca(2+) and NO by VEGF165 alone, as well as the effect of VEGF165 on subsequent ATP-stimulated Ca(2+) signaling and NO production...
November 11, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27829661/pathophysiology-of-preeclampsia-an-angiogenic-imbalance-and-long-lasting-systemic-vascular-dysfunction
#4
Takuji Tomimatsu, Kazuya Mimura, Masayuki Endo, Keiichi Kumasawa, Tadashi Kimura
Preeclampsia is a systemic vascular disorder characterized by new-onset hypertension and proteinuria after 20 weeks of gestation. This condition targets several organs, including the kidneys, liver and brain, and is the leading cause of maternal and perinatal morbidity and mortality. Furthermore, recent evidence has revealed preeclampsia as a significant risk factor for future cardiovascular diseases in these women. Over the past decade, increasing evidence has indicated that maternal angiogenic imbalances caused by placental antiangiogenic factors play a central role in the systemic vascular dysfunction underling preeclampsia...
November 10, 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/27818713/mechanism-of-enhanced-cellular-uptake-and-cytosolic-retention-of-mk2-inhibitory-peptide-nano-polyplexes
#5
Kameron V Kilchrist, Brian C Evans, Colleen M Brophy, Craig L Duvall
Electrostatic complexation of a cationic MAPKAP kinase 2 inhibitory (MK2i) peptide with the anionic, pH-responsive polymer poly(propylacrylic acid) (PPAA) yields MK2i nano-polyplexes (MK2i-NPs) that significantly increase peptide uptake and intracellular retention. This study focused on elucidating the mechanism of MK2i-NP cellular uptake and intracellular trafficking in vascular smooth muscle cells. Small molecule inhibition of various endocytic pathways showed that MK2i-NP cellular uptake involves both macropinocytosis and clathrin mediated endocytosis, whereas the free peptide exclusively utilizes clathrin mediated endocytosis for cell entry...
September 2016: Cellular and Molecular Bioengineering
https://www.readbyqxmd.com/read/27803400/excess-visceral-adipose-tissue-worsens-the-vascular-endothelial-function-in-patients-with-type-2-diabetes-mellitus
#6
Akira Kurozumi, Yosuke Okada, Tadashi Arao, Yoshiya Tanaka
Objective Visceral fat obesity and metabolic syndrome correlate with atherosclerosis in part due to insulin resistance and various other factors. The aim of this study was to determine the relationship between vascular endothelial dysfunction and excess visceral adipose tissue (VAT) in Japanese patients with type 2 diabetes mellitus (T2DM). Methods In 71 T2DM patients, the reactive hyperemia index (RHI) was measured using an Endo-PAT 2000, and VAT and subcutaneous adipose tissue (SAT) were measured via CT. We also measured various metabolic markers, including high-molecular-weight adiponectin (HMW-AN)...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27753095/store-operated-stim1-translocation-and-interaction-with-trpc1-at-the-plasma-membrane-stimulates-plc-activity-to-induce-channel-gating-in-vascular-smooth-muscle-cells
#7
Jian Shi, Francesc Miralles, Lutz Birnbaumer, William A Large, Anthony P Albert
In vascular smooth muscle cells (VSMCs), stimulation of TRPC1-based SOCs mediate Ca(2+) entry pathways which regulate contractility, proliferation and migration. It is therefore important to understand how these channels are activated. Studies have shown that stimulation of TRPC1-based SOCs requires Gαq/PLCβ1 activities and PKC phosphorylation, but it is unclear how store depletion stimulates this gating pathway. The present work examines this issue by focusing on the role of STIM1, an endo/sarcoplasmic reticulum Ca(2+) sensor...
October 18, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27719648/therapeutic-interventions-for-advanced-glycation-end-products-and-its-receptor-mediated-cardiovascular-disease
#8
Kailash Prasad, Shuchita Tiwari
Advanced glycation end products (AGEs) are heterogeneous group of molecules formed from non-enzymatic reaction of reducing sugars with amino group of proteins, lipids, and nucleic acid. Interaction of AGEs with its cell-bound receptor (RAGE) results in generation of oxygen radicals, nuclear factor kappa-β, pro-inflammatory cytokines and cell adhesion molecules, and is involved in the pathophysiology of cardiovascular diseases (CVD). Circulating soluble forms of RAGE (sRAGE) and endo-secretory RAGE (esRAGE) compete with RAGE for ligand binding and function as a decoy...
October 6, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27702746/caspase-1-deficiency-promotes-high-fat-diet-induced-adipose-tissue-inflammation-and-the-development-of-obesity
#9
Hiroaki Kimura, Tadayoshi Karasawa, Fumitake Usui, Akira Kawashima, Yuka Endo, Motoi Kobayashi, Ai Sadatomo, Jun Nakamura, Yusaku Iwasaki, Toshihiko Yada, Hiroko Tsutsui, Tadashi Kasahara, Masafumi Takahashi
Caspase-1 is a cysteine protease responsible for the processing of the proinflammatory cytokine interleukin-1β and activated by the formation of inflammasome complexes. Although several investigations have found a link between diet-induced obesity and caspase-1, the relationship of remains controversial. Here, we found that mice deficient in caspase-1 were susceptible to high-fat diet-induced obesity with increased adiposity as well as normal lipid and glucose metabolism. Caspase-1 deficiency clearly promoted the infiltration of inflammatory macrophages and increased the production of C-C motif chemokine ligand 2 (CCL2) in the adipose tissue...
October 4, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27682162/map-based-cloning-and-characterization-of-the-bph18-gene-from-wild-rice-conferring-resistance-to-brown-planthopper-bph-insect-pest
#10
Hyeonso Ji, Sung-Ryul Kim, Yul-Ho Kim, Jung-Pil Suh, Hyang-Mi Park, Nese Sreenivasulu, Gopal Misra, Suk-Man Kim, Sherry Lou Hechanova, Hakbum Kim, Gang-Seob Lee, Ung-Han Yoon, Tae-Ho Kim, Hyemin Lim, Suk-Chul Suh, Jungil Yang, Gynheung An, Kshirod K Jena
Brown planthopper (BPH) is a phloem sap-sucking insect pest of rice which causes severe yield loss. We cloned the BPH18 gene from the BPH-resistant introgression line derived from the wild rice species Oryza australiensis. Map-based cloning and complementation test revealed that the BPH18 encodes CC-NBS-NBS-LRR protein. BPH18 has two NBS domains, unlike the typical NBS-LRR proteins. The BPH18 promoter::GUS transgenic plants exhibited strong GUS expression in the vascular bundles of the leaf sheath, especially in phloem cells where the BPH attacks...
September 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27647027/traumatic-spinal-perimedullary-arteriovenous-fistula-induced-by-a-cervical-glass-stab-injury
#11
Shogo Ogita, Toshiki Endo, Tomoo Inoue, Kenichi Sato, Hidenori Endo, Teiji Tominaga
BACKGROUND: In the literature, perimedullary arteriovenous fistula (AVF) is an uncommon spinal vascular malformation that is generally regarded as a congenital lesion. To our knowledge, only a few cases of traumatic perimedullary AVF have been reported in the literature so far. CASE DESCRIPTION: A 58-year-old man presented with subarachnoid hemorrhage (SAH) resulting from a secondary perimedullary arteriovenous fistula (AVF) induced by a glass stab injury to his right posterior neck...
September 16, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27625377/blood-flow-into-basilar-tip-aneurysms-a-predictor-for-recanalization-after-coil-embolization
#12
Shin-Ichiro Sugiyama, Kuniyasu Niizuma, Kenichi Sato, Sherif Rashad, Misaki Kohama, Hidenori Endo, Toshiki Endo, Yasushi Matsumoto, Makoto Ohta, Teiji Tominaga
BACKGROUND AND PURPOSE: Hemodynamic forces may play a role in the recanalization of coiled aneurysms. The purpose of this study was to investigate the influence of presurgical hemodynamics on the efficacy of coil embolization for basilar tip aneurysms. METHODS: We identified 82 patients who underwent endovascular coil embolization for basilar tip aneurysms with a follow-up of >1 year. Presurgical hemodynamics were investigated using computational fluid dynamics with 3-dimensional data derived from rotational angiography...
October 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27616748/siah-1-is-associated-with-expression-of-hypoxia-inducible-factor-1%C3%AE-in-oral-squamous-cell-carcinoma
#13
Mitsuharu Aga, Satoru Kondo, Naohiro Wakisaka, Makiko Moriyama-Kita, Kazuhira Endo, Yosuke Nakanishi, Shigeyuki Murono, Hisashi Sugimoto, Takayoshi Ueno, Tomokazu Yoshizaki
OBJECTIVE: Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric basic helix-loop-helix transcription factor composed of the HIF-1α and HIF-1β subunits. HIF-1 is a central regulator of responses to hypoxia; it enhances metastasis-related factors such as matrix metalloproteinases and vascular endothelial growth factor (VEGF). We have reported critical roles for HIF-1α in tumor microenvironments, and oncogenic properties of HIF-1α have been suggested in malignancies. Seven in absentia homologue (Siah) appeared to upregulate HIF-1 production, which prompted us to investigate the Siah association with HIF-1α expression in oral squamous cell carcinoma (OSCC)...
September 8, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27593938/tumour-cell-derived-wnt5b-modulates-in-vitro-lymphangiogenesis-via-induction-of-partial-endothelial-mesenchymal-transition-of-lymphatic-endothelial-cells
#14
S-H Wang, J S Chang, J-R Hsiao, Y-C Yen, S S Jiang, S-H Liu, Y-L Chen, Y-Y Shen, J-Y Chang, Y-W Chen
Metastasis of the cervical lymph nodes frequently leads to poor survival of patients with oral squamous cell carcinoma (OSCC). The underlying mechanisms of lymph node metastasis are unclear. Wingless-type MMTV integration site family, member 5B (WNT5B), one component of the WNT signal pathway, was markedly up-regulated in OSCC sublines with high potential of lymphatic metastasis compared to that in OSCC cells with low nodal metastasis. Increased WNT5B mRNA was demonstrated in human OSCC tissues in comparison with adjacent non-tumorous tissues...
September 5, 2016: Oncogene
https://www.readbyqxmd.com/read/27592734/outcome-for-endovascular-and-open-procedures-in-infrapopliteal-lesions-for-critical-limb-ischemia-registry-based-single-center-study
#15
F Gentile, G Lundberg, R Hultgren
OBJECTIVE/BACKGROUND: To describe the risk factor distribution and outcome for patients with critical limb ischemia (CLI) due to infrapopliteal arterial lesions treated by endovascular or open procedures, with special consideration of diabetic patients. METHODS: Data were collected from the Swedish Vascular Registry, Swedvasc, covering all procedures performed on 549 consecutive patients between May 2008 and January 2014 at the Karolinska University Hospital. Diagnosis of ischemic rest pain and/or tissue loss and treatment of infrapopliteal arterial occlusive disease were considered...
September 1, 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27575680/endoscopic-transsphenoidal-surgery-using-pedicle-vascularized-nasoseptal-flap-for-cholesterol-granuloma-in-petrous-apex-a-technical-note
#16
Yukitomo Ishi, Hiroyuki Kobayashi, Hiroaki Motegi, Shogo Endo, Shigeru Yamaguchi, Shunsuke Terasaka, Kiyohiro Houkin
BACKGROUND: Compared with surgical resection, endoscopic transsphenoidal surgery (TSS) for cholesterol granuloma (CG) in the petrous apex (PA) is associated with local recurrence due to obstruction of the drainage route. We present a detailed procedure of an endoscopic TSS using pedicle vascularized nasoseptal flap (PVNF). METHODS: A 40-year-old woman with a history of repeated surgery for left tympanitis was referred to our institution. Neurological examination revealed severe hearing loss in the left ear...
August 20, 2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/27562783/%C3%AE-1-3-glucans-are-components-of-brown-seaweed-phaeophyceae-cell-walls
#17
Sandra Cristina Raimundo, Sivakumar Pattathil, Stefan Eberhard, Michael G Hahn, Zoë A Popper
LAMP is a cell wall-directed monoclonal antibody (mAb) that recognizes a β-(1,3)-glucan epitope. It has primarily been used in the immunolocalization of callose in vascular plant cell wall research. It was generated against a brown seaweed storage polysaccharide, laminarin, although it has not often been applied in algal research. We conducted in vitro (glycome profiling of cell wall extracts) and in situ (immunolabeling of sections) studies on the brown seaweeds Fucus vesiculosus (Fucales) and Laminaria digitata (Laminariales)...
August 25, 2016: Protoplasma
https://www.readbyqxmd.com/read/27558002/evaluation-of-the-vascular-protective-effects-of-new-oral-anticoagulants-in-high-risk-patients-with-atrial-fibrillation-prefer-af-study-protocol-for-a-randomized-controlled-trial
#18
Jin-Bae Kim, Hyun Jun Joung, Jung Myung Lee, Jong Shin Woo, Woo-Shik Kim, Kwon Sam Kim, Kyung Hye Lee, Weon Kim
BACKGROUND: Atrial fibrillation (AF) is known to be associated with several pathophysiological mechanisms including endothelial dysfunction of the heart and arterial vessels. Recent evidence suggests that new oral anticoagulant (NOAC) treatment may improve endothelial function and the inflammatory process involved in atherosclerosis in AF patients. This study is designed to determine the efficacy of NOAC therapy in the prevention of endothelial dysfunction and the progression of atherosclerosis of AF subjects...
2016: Trials
https://www.readbyqxmd.com/read/27554072/development-of-abnormal-hemispheric-vascular-networks-mimicking-cerebral-proliferative-angiopathy-in-a-child-originally-diagnosed-with-deep-seated-arteriovenous-fistula
#19
Hiroyuki Sakata, Miki Fujimura, Kenichi Sato, Kuniyasu Niizuma, Hidenori Endo, Teiji Tominaga
Cerebral proliferative angiopathy (CPA), which is characterized by diffuse vascular abnormalities with intermingled normal brain parenchyma, is a rare clinical entity distinct from classical cerebral arteriovenous malformations. Its pathology at initial state and subsequent course of progression has totally been undetermined. We herein presented a case of a child who was initially diagnosed with deep-seated arteriovenous fistula (AVF), and ultimately developed symptomatic CPA-like vascular lesion over a long period of clinical follow-up...
October 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27545033/-management-of-endo-graft-infection-following-endovascular-repair-of-abdominal-aortic-aneurysm
#20
H H Yin, M Wang, Z L Li, C Yao, Z J Hu, J S Wang, G Q Chang, S M Wang
OBJECTIVE: To summarize our experience in the management of stent-graft infection after endo-vascular aortic repair (EVAR) of abdominal aortic aneurysm (AAA). METHODS: Data of patients who were diagnosed as endo-graft infection following EVAR and admitted in our center between January 2000 and December 2015 were reviewed. Clinical records including causes of infection, medical history, re-operative procedures, and prognostic data were analysed. RESULTS: A total of 10 male patients, aged 45-72 years (averaged 62...
August 9, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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