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https://www.readbyqxmd.com/read/29610557/dietary-intake-of-inorganic-phosphorus-has-a-stronger-influence-on-vascular-endothelium-function-than-organic-phosphorus
#1
Hiromi Kawamura, Sarasa Tanaka, Yuri Ota, Sumire Endo, Mariko Tani, Midori Ishitani, Motoyoshi Sakaue, Mikiko Ito
Phosphorus management through dietetic therapy is vital for the prevention of cardiovascular disease in chronic kidney disease patients. There are two main sources of phosphorus in the diet, organic phosphorus from protein and inorganic phosphorus from food additives. The adverse effects of high phosphorus intake on vascular-endothelium function have been reported; however, the differences in the effects of organic phosphorus versus inorganic phosphorus are not clear. In this study, we examined an acute effect of these high phosphorus meals intake on vascular-endothelium function...
March 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/29610036/paradoxical-association-of-symptomatic-local-vasogenic-edema-with-global-cerebral-hypoperfusion-after-direct-revascularization-surgery-for-adult-moyamoya-disease
#2
Ryosuke Tashiro, Miki Fujimura, Shunji Mugikura, Kuniyasu Niizuma, Hidenori Endo, Toshiki Endo, Teiji Tominaga
BACKGROUND: Superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis is the standard treatment for Moyamoya disease (MMD). Cerebral hyperperfusion syndrome is a potential complication of this procedure and can cause local vasogenic edema and/or delayed intracerebral hemorrhage. Cerebral hypoperfusion is a contradictory postoperative pathophysiological condition implicated in MMD, but its association with symptomatic local vasogenic edema has not been reported. CASE REPORT: A 31-year-old woman with MMD underwent left STA-MCA anastomosis 3 months after a minor completed stroke in bilateral hemispheres...
March 30, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29573275/a-role-for-alf4-during-gall-and-giant-cell-development-in-the-biotic-interaction-between-arabidopsis-and-meloidogyne-spp
#3
Rocio Olmo, Javier Cabrera, Carmen Fenoll, Carolina Escobar
Root-knot nematodes (RKNs; Meloidogyne spp.) are a major pest for the agriculture worldwide. RKNs induce specialized feeding cells (giant cells; GCs) inside galls which are de novo formed pseudo-organs in the roots that share similarities with other developmental processes as lateral root (LR) and callus formation or grafting involving new vascular development or pericycle proliferation. Hence, it is pertinent to study the molecular mechanisms directing the plant-nematode interaction. In this respect, ALF4 is a key gene during lateral root (LR) formation, vascular vessels reconnection in grafting, hormone-induced callus formation or de novo root organogenesis from leaf explants...
March 24, 2018: Physiologia Plantarum
https://www.readbyqxmd.com/read/29553089/is-trisomy-21-a-risk-factor-for-rapid-progression-of-pulmonary-arteriopathy-revisiting-histopathological-characteristics-using-282-lung-biopsy-specimens
#4
Naoki Masaki, Yuriko Saiki, Masato Endo, Kay Maeda, Osamu Adachi, Masatoshi Akiyama, Shunsuke Kawamoto, Yoshikatsu Saiki
BACKGROUND: Pulmonary hypertension (PH) is more progressive in trisomy 21 patients. However, pulmonary arteriopathic lesions in these patients have not been fully characterized histopathologically.Methods and Results:A retrospective review of a lung biopsy registry identified 282 patients: 188 patients with trisomy 21 (Group D) and 94 without (Group N). The mean age at lung biopsy was 3 and 7 months (P<0.0001). Pulmonary arterial pressure (PAP) and pulmonary vascular resistance were similar between the 2 groups...
March 16, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29548823/arginase-controls-soluble-vascular-endothelial-growth-factor-receptor-1-flt1-to-maintain-pregnancy-homeostasis
#5
Hiroko Tanaka, Keiichi Kumasawa, Aiko Kakigano, Kazuya Mimura, Masayuki Endo, Takuji Tomimatsu, Tadashi Kimura
Excessive soluble fms-like tyrosine kinase-1 (sFlt-1) has been strongly implicated in preeclampsia. An increase in the serum sFlt-1 level occurs before the onset of preeclampsia, and the sFlt-1 level is already higher in women who are predisposed to preeclampsia than in normotensive pregnant women. This study aimed to investigate the relation between arginase and sFlt-1 in the plasma of preeclamptic women and normotensive pregnant women. We suggested that a regulatory mechanism exists that suppresses the level of sFlt-1...
March 13, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29546793/resection-of-puncture-site-necrosis-over-an-arteriovenous-fistula-endoclamp-use-for-preservation-of-cannulation-sites
#6
Alexandros Mallios, William Jennings, Benoit Boura, Alessandro Costanzo, Myriam Combes
Skin necrosis overlying an arteriovenous fistula at the cannulation site is a common and potentially life-threatening problem, often associated with underlying aneurysm formation. Arteriovenous fistula-skin necrosis generally requires resection of surrounding skin margins and the underlying aneurysmal vessel wall, allowing repair with healthy tissue of the arteriovenous fistula in addition to closure of soft tissue and skin. In patients with insufficient fistula length, salvage of these arteriovenous fistulas may result in difficult or insurmountable cannulation issues leading to attempts at one-needle cannulation dialysis or, most often, catheter placement...
March 1, 2018: Journal of Vascular Access
https://www.readbyqxmd.com/read/29527330/etv2-mediates-endothelial-transdifferentiation-of-glioblastoma
#7
Chengjian Zhao, Gustavo A Gomez, Yuwei Zhao, Yu Yang, Dan Cao, Jing Lu, Hanshuo Yang, Shuo Lin
Glioblastoma multiforme (GBM) is characterized by extensive endothelial hyperplasia. Recent studies suggest that a subpopulation of endothelial cells originates via vasculogenesis by the transdifferentiation of GBM tumor cells into endothelial cells (endo-transdifferentiation). The molecular mechanism underlying this process remains poorly defined. Here, we show that the expression of ETS variant 2 (ETV2), a master regulator of endothelial cell development, is highly correlated with malignancy. Functional studies demonstrate that ETV2 is sufficient and necessary for the transdifferentiation of a subpopulation of CD133+/Nestin+ GBM/neural stem cells to an endothelial lineage...
2018: Signal Transduction and Targeted Therapy
https://www.readbyqxmd.com/read/29486231/recent-trends-in-publications-of-us-and-european-directors-in-vascular-surgery
#8
Afsha Aurshina, Anil Hingorani, Amrit Hingorani, Natalie Marks, Enrico Ascher
OBJECTIVE: We hypothesized that there may be significant differences between academic productivity of the vascular training programs in the United States (US) and Europe. In an effort to explore theory, we reviewed the number of vascular publications listed in PubMed from 2010 to 2015 for US and European directors in vascular surgery. METHODS: The list of program directors from the Association of Program directors in Vascular Surgery (APDVS) and the European Union of Medical Specialists (EUMS) were queried for the names of the directors of vascular surgical training programs at the end of 2015...
February 24, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29484444/autophagy%C3%A2-mediated-adaptation-of-hepatocellular-carcinoma-cells-to-hypoxia%C3%A2-mimicking-conditions-constitutes-an-attractive-therapeutic-target
#9
Satoshi Owada, Hitoshi Endo, Yukari Shida, Chisa Okada, Kanako Ito, Takahiro Nezu, Masayuki Tatemichi
Hepatocellular carcinoma has extremely poor prognosis. In cancerous liver tissues, aberrant proliferation of cancer cells leads to the creation of an area where an immature vascular network is formed. Since oxygen is supplied to cancer tissues through the bloodstream, a part of the tumor is exposed to hypoxic conditions. As hypoxia is known to severely reduce the effectiveness of existing anticancer agents, novel valid therapeutic targets must be identified for the treatment of hepatocellular carcinoma. Generally, autophagy has been reported to play an important role in the adaptation of cancer cells to hypoxia...
February 23, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29479417/the-role-of-tevar-in-the-management-of-a-recurrent-aorto-gastric-fistula
#10
Terri-Ann T Russell, Pranitha Pinnamaraju, Maher Hamish
An aorto-gastric fistula is a catastrophic and rare cause of an upper gastrointestinal bleed. The diagnosis requires a high index of suspicion and expedient management as any delay in each of these component, will be to the detriment of the patient. We report a case of a patient with two episodes of this rare event, with haemodynamic compromise, 15 years after having had a trans-hiatal oesophagectomy for an adenocarcinoma of the oesophagus who presented on both occasions. He had thoracic endo-vascular aortic repair (TEVAR) on both presentations and survived...
February 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29467541/inhibition-of-endo-lysosomal-function-exacerbates-vascular-calcification
#11
Yujun Cai, Xue-Lin Wang, Alyssa M Flores, Tonghui Lin, Raul J Guzman
Vascular calcification is a pathologic response to mineral imbalances and is prevalent in atherosclerosis, diabetes mellitus, and chronic kidney disease. When located in the media, it is highly associated with increased cardiovascular morbidity and mortality, particularly in patients on dialysis. Vascular calcification is tightly regulated and controlled by a series of endogenous factors. In the present study, we assess the effects of lysosomal and endosomal inhibition on calcification in vascular smooth muscle cells (VSMCs) and aortic rings...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29459015/endovascular-interventions-decrease-length-of-hospitalization-and-are-cost-effective-in-acute-mesenteric-ischemia
#12
Young Erben, Clinton D Protack, Raymond A Jean, Brandon J Sumpio, Samuel M Miller, Shirley Liu, Gerardo Trejo, Bauer E Sumpio
OBJECTIVE: Acute mesenteric ischemia (AMI) continues to be one of the most devastating diagnoses requiring emergent vascular intervention. There is a national trend toward increased use of endovascular procedures, with improved survival for the treatment of these patients. Our aim was to evaluate whether this trend has changed the treatment of AMI and the subsequent impact on length of hospitalization and hospitalization costs. METHODS: We identified all patients admitted for AMI from the National Inpatient Sample from 2004 to 2014 who received open surgical revascularization (OPEN) or an endovascular intervention (ENDO)...
February 16, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29398035/perioperative-and-long-term-outcome-of-intrahepatic-cholangiocarcinoma-involving-the-hepatic-hilus-after-curative-intent-resection-comparison-with-peripheral-intrahepatic-cholangiocarcinoma-and-hilar-cholangiocarcinoma
#13
Xu-Feng Zhang, Fabio Bagante, Qinyu Chen, Eliza W Beal, Yi Lv, Matthew Weiss, Irinel Popescu, Hugo P Marques, Luca Aldrighetti, Shishir K Maithel, Carlo Pulitano, Todd W Bauer, Feng Shen, George A Poultsides, Olivier Soubrane, Guillaume Martel, B Groot Koerkamp, Alfredo Guglielmi, Endo Itaru, Timothy M Pawlik
BACKGROUND: Intrahepatic cholangiocarcinoma with hepatic hilus involvement has been either classified as intrahepatic cholangiocarcinoma or hilar cholangiocarcinoma. The present study aimed to investigate the clinicopathologic characteristics and short- and long-term outcomes after curative resection for hilar type intrahepatic cholangiocarcinoma in comparison with peripheral intrahepatic cholangiocarcinoma and hilar cholangiocarcinoma. METHODS: A total of 912 patients with mass-forming peripheral intrahepatic cholangiocarcinoma, 101 patients with hilar type intrahepatic cholangiocarcinoma, and 159 patients with hilar cholangiocarcinoma undergoing curative resection from 2000 to 2015 were included from two multi-institutional databases...
February 2, 2018: Surgery
https://www.readbyqxmd.com/read/29397865/the-role-of-purkinje-cell-derived-vegf-in-cerebellar-astrogliosis-in-niemann-pick-type-c-mice
#14
Min Hee Park, Ju Youn Lee, Min Seock Jeong, Hyung Sup Jang, Shogo Endo, Jae-Sung Bae, Hee Kyung Jin
Niemann-Pick type C disease (NP-C) is a fatal neurodegenerative disorder caused by a deficiency of NPC1 gene function, which leads to severe neuroinflammation such as astrogliosis. While reports demonstrating neuroinflammation are prevalent in NP-C, information about the onset and progression of cerebellar astrogliosis in this disorder is lacking. Using gene targeting, we generated vascular endothelial growth factor (VEGF) conditional null mutant mice. Deletion of VEGF in cerebellar Purkinje neurons (PNs) led to a significant increase of astrogliosis in the brain of NP-C mice in addition to the loss of PNs, suggesting PN-derived VEGF as an important factor in NP-C pathology...
February 5, 2018: BMB Reports
https://www.readbyqxmd.com/read/29390282/giant-solitary-fibrous-tumor-of-the-pleura-with-high-grade-sarcomatous-overgrowth-accompanied-by-lipid-rich-rhabdomyosarcomatous-and-pleomorphic-components-a-case-report
#15
Takeo Nakaya, Hisashi Oshiro, Ayako Takigami, Yoshihiko Kanai, Kenji Tetsuka, Koichi Hagiwara, Hirofumi Fujii, Shunsuke Endo, Akira Tanaka
RATIONALE: Solitary fibrous tumors are mesenchymal tumors presenting as fibroblastic neoplasms with prominent branching vascular patterns, which are often generated from the pleura. Most solitary fibrous tumors are benign; however, some can turn malignant. High-grade sarcomas from solitary fibrous tumors include multidirectional histopathological components. PATIENT CONCERNS: We describe our experience of a giant high-grade sarcoma with mixed components generated from a solitary fibrous tumor of the pleura in a 67-year-old female patient presenting with cough and left-sided chest pain...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29363720/antitumor-effects-of-tubeimoside-1-in-nci-h1299-cells-are-mediated-by-microrna-126-5p-induced-inactivation-of-vegf-a-vegfr-2-erk-signaling-pathway
#16
Hanbing Shi, Hongxia Bi, Xingyuan Sun, Haiying Dong, Yunfei Jiang, Haijun Mu, Guohua Liu, Weili Kong, Ruizhi Gao, Jiang Su
Tubeimoside-1 (TBMS1), a triterpenoid saponin isolated from the tuber of Bolbostemma paniculatum (Maxim) Franquet, serves an universal suppressive role in multiple cancer types, including lung cancer. However, the mechanism involved in non‑small cell lung cancer (NSCLC) cells by which TBMS1 elicits its antitumor effects is not yet comple-tely understood. The present study indicated that 10 µmol/l TBMS1 significantly enhanced apoptosis and notably blocked the migration and invasion of NCI‑H1299 cells...
March 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29279500/hepatic-angiomyolipoma-staining-in-the-post-vascular-phase-of-contrast-enhanced-ultrasound-due-to-the-presence-of-macrophages
#17
Kei Endo, Hidekatsu Kuroda, Keisuke Kakisaka, Takayoshi Oikawa, Kei Sawara, Kazuyuki Ishida, Tamotsu Sugai, Yasuhiro Takikawa
A 47-year-old Japanese man was referred to hospital after the detection of a liver tumor. Dynamic computed tomography and Gd-EOB-DTPA-enhanced magnetic resonance imaging were consistent with a diagnosis of hepatocellular carcinoma (HCC). No perfusion defect was observed in the post-vascular phase of contrast-enhanced ultrasound (CEUS). Histopathological staining of the tumor cells was positive for antibodies against HMB-45 and CD68, confirming the diagnosis of hepatic angiomyolipoma (HAML). These findings indicated the presence of macrophages in HAML...
December 27, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29249737/evidence-of-pulmonary-vascular-reverse-remodeling-after-pulmonary-artery-banding-performed-in-early-infancy-in-patients-with-congenital-heart-defects
#18
Naoki Masaki, Yuriko Saiki, Masato Endo, Kay Maeda, Osamu Adachi, Masatoshi Akiyama, Shunsuke Kawamoto, Yoshikatsu Saiki
BACKGROUND: Histomorphometric evidence of the effect of pulmonary artery banding (PAB) in infancy on pulmonary vascular reverse remodeling has not been fully described.Methods and Results:We retrospectively reviewed 34 patients who underwent serial lung biopsies before and after PAB.Index of pulmonary vascular disease (IPVD) as a measure of the degree of progression of pulmonary arteriopathy significantly decreased after PAB (1.22±0.25 at 1st and 1.13±0.21 at 2nd biopsy, P=0.04)...
February 23, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29218644/cardiovascular-complications-of-marijuana-and-related-substances-a-review
#19
REVIEW
Amitoj Singh, Sajeev Saluja, Akshat Kumar, Sahil Agrawal, Munveer Thind, Sudip Nanda, Jamshid Shirani
The recreational use of cannabis has sharply increased in recent years in parallel with its legalization and decriminalization in several countries. Commonly, the traditional cannabis has been replaced by potent synthetic cannabinoids and cannabimimetics in various forms. Despite overwhelming public perception of the safety of these substances, an increasing number of serious cardiovascular adverse events have been reported in temporal relation to recreational cannabis use. These have included sudden cardiac death, vascular (coronary, cerebral and peripheral) events, arrhythmias and stress cardiomyopathy among others...
December 7, 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/29209775/effect-of-aggressive-lipid-lowering-treatment-with-rosuvastatin-on-vascular-endothelium-function-evaluation-of-vascular-endothelium-function-earth-study
#20
Tadateru Takayama, Takafumi Hiro, Shunichi Yoda, Daisuke Fukamachi, Hironori Haruta, Takaaki Kogo, Takashi Mineki, Hironobu Murata, Toru Oshima, Atsushi Hirayama
Vascular endothelial dysfunction plays an important role in the process of atherosclerosis up to the final stage of plaque rupture. Vascular endothelial dysfunction is reversible, and can be recovered by medications and life-style changes. Improvement in endothelial function may reduce cardiovascular events and improve long-term prognosis. A total of 50 patients with stable angina and dyslipidemia were enrolled, including patients who had not received prior treatment with statins and had serum LDL-C levels ≥ 100 mg/dL, and patients who had previously received statin treatment...
December 5, 2017: Heart and Vessels
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