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https://www.readbyqxmd.com/read/29447137/emerging-therapies-for-neuropathic-pain-new-molecules-or-new-indications-for-old-treatments
#1
Didier Bouhassira, Nadine Attal
Neuropathic pain represents a highly unmet medical need because most of the available treatments have a modest efficacy or dose-limiting side effects. Hence, novel therapeutic perspectives are warranted. Many compounds acting on new pain targets are in preclinical or early clinical development. Only few clinical trials have suggested their clinical relevance in neuropathic pain. This concerns in particular NaV1.7 antagonists and angiotensin type II inhibitors. Another type of emerging drug therapy in neuropathic pain is represented by drugs largely used for other indications, such as botulinum toxin A and the antiepileptic oxcarbazepine, which have recently found to be effective in peripheral neuropathic pain...
March 2018: Pain
https://www.readbyqxmd.com/read/29443722/characterizing-treatment-utilization-patterns-for-trigeminal-neuralgia-in-the-united-states
#2
Joanna M Zakrzewska, Ning Wu, John Y K Lee, Brian Werneburg, Deborah Hoffman, Ying Liu
BACKGROUND AND AIM: Trigeminal neuralgia (TN) is a rare orofacial disorder characterized by severe unilateral paroxysmal pain in the region of the fifth cranial nerve. Clinical guidelines recommend carbamazepine (only US Food and Drug Administration-approved drug for TN) and oxcarbazepine as first-line therapies. We utilized the US Truven Health MarketScan database to examine treatment patterns among patients with TN. METHODS: Included patients were aged ≥18 years, newly diagnosed with TN (≥2 TN diagnoses ≥14 days apart; no diagnosis in the prior year), continuously enrolled 1 year pre-index, with ≥3 years' follow-up post-index...
February 13, 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29442362/a-descriptive-systematic-review-of-salivary-tdm-in-neonates-and-infants
#3
Laura Hutchinson, Marlene Sinclair, Bernadette Reid, Kathryn Burnett, Bridgeen Callan
INTRODUCTION: Saliva, as a matrix, offers many benefits over blood in therapeutic drug monitoring (TDM), in particular for infantile TDM. However, the accuracy of salivary TDM in infants remains an area of debate. This review explored the accuracy, applicability and advantages of using saliva TDM in infants and neonates. METHODS: Databases were searched up to and including September 2016. Studies were included based on PICO as follows: P: Infants and neonates being treated with any medication, I: Salivary Therapeutic Drug Monitoring vs C: Traditional methods and O: accuracy, advantages/disadvantages and applicability to practice...
February 14, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29427285/effect-of-tadalafil-on-seizure-threshold-and-activity-of-antiepileptic-drugs-in-three-acute-seizure-tests-in-mice
#4
Katarzyna Socała, Dorota Nieoczym, Mateusz Pieróg, Elżbieta Wyska, Małgorzata Szafarz, Urszula Doboszewska, Piotr Wlaź
Tadalafil, a selective phosphodiesterase type 5 inhibitor, is a long-acting oral agent for the treatment of erectile dysfunction of multiple etiologies. Although generalized tonic-clonic seizures were reported in a healthy man after taking tadalafil, the influence of tadalafil on seizure susceptibility has not been studied so far. Therefore, the aim of the present study was to investigate the effect of tadalafil on seizure threshold as well as on the activity of some first- and second-generation antiepileptic drugs in three acute seizure tests in mice...
February 9, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29414565/current-state-of-the-union-of-epilepsy-care-in-the-united-states-antiepileptic-drugs-an-introduction-to-the-connectors-project
#5
Joseph I Sirven, Patricia O Shafer, Linda Kalilani, Imane Wild, Jesse Fishman, Steve Owens
PURPOSE: How antiepileptic drugs (AEDs) are used in the United States (US) is one proxy public health indicator for the current state of epilepsy management. The use of phenytoin, other older AEDs, and newer AEDs may act as an indicator for the quality of epilepsy practice in addition to the current American Academy of Neurology quality measures. Data on AED used by states and populations can help identify which public health interventions are necessary to improve the status of epilepsy care...
February 1, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29392710/clinical-pharmacogenetics-implementation-consortium-guideline-for-hla-genotype-and-use-of-carbamazepine-and-oxcarbazepine-2017-update
#6
Elizabeth J Phillips, Chonlaphat Sukasem, Michelle Whirl-Carrillo, Daniel J Müller, Henry M Dunnenberger, Wasun Chantratita, Barry Goldspiel, Yuan-Tsong Chen, Bruce C Carleton, Alfred L George, Taisei Mushiroda, Teri Klein, Roseann S Gammal, Munir Pirmohamed
The variant allele HLA-B*15:02 is strongly associated with greater risk of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients treated with carbamazepine or oxcarbazepine. The variant allele HLA-A*31:01 is associated with greater risk of maculopapular exanthema, drug reaction with eosinophilia and systemic symptoms, and SJS/TEN in patients treated with carbamazepine. We summarize evidence from the published literature supporting these associations and provide recommendations for carbamazepine and oxcarbazepine use based on HLA genotypes...
February 2, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29389596/flavonoid-compounds-as-reversing-agents-of-the-p-glycoprotein-mediated-multidrug-resistance-an-in-vitro-evaluation-with-focus-on-antiepileptic-drugs
#7
Ana Ferreira, Márcio Rodrigues, Ana Fortuna, Amílcar Falcão, Gilberto Alves
The pharmacoresistance to antiepileptic drugs (AEDs) remains a major unsolved therapeutic need. The overexpression of multidrug transporters, as the P-glycoprotein (P-gp), at the level of the blood-brain barrier of epileptic patients has been suggested as a key mechanism underlying the refractory epilepsy. Thus, efforts have been made to search for therapeutically useful P-gp inhibitors. Herein, the strategy of flavonoid/AED combined therapy was exploited as a possible approach to overcome the P-gp-mediated pharmacoresistance...
January 2018: Food Research International
https://www.readbyqxmd.com/read/29377062/adverse-effects-of-anti-epileptics-in-trigeminal-neuralgiform-pain
#8
V Tentolouris-Piperas, G Lee, J Reading, A G O'Keeffe, J M Zakrzewska, R Cregg
BACKGROUND: Side effects of anti-epileptic drugs (AEDs) have not been adequately documented in trigeminal neuralgia and its variants. The aim of this observational cross-sectional study was to compare the A-B Neuropsychological Assessment Schedule (ABNAS), which measures cognitive side effects to the Adverse Events Profile (AEP), which looks at a broader range of side effects, and to investigate drug/dosage relationships with questionnaire scores to help determine a point at which a drug change would be indicated...
January 28, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29370880/association-between-hla-genotypes-and-oxcarbazepine-induced-cutaneous-adverse-drug-reactions-a-systematic-review-and-meta-analysis
#9
Wimonchat Tangamornsuksan, Norman Scholfield, Manupat Lohinavy
PURPOSE: To systematically review and quantitatively synthesize associations between HLA genotypes and oxcarbazepine-induced cutaneous adverse drug reactions (OXC-cADRs), including Stevens-Johnson syndrome (SJS) and maculopapular rash. METHODS: Studies investigating associations between HLA genotypes and OXC-cADRs were systematically searched irrespective of language, in PubMed, HuGENet (Human Genome Epidemiology Network), and the Cochrane Library from their inception until January, 2017...
2018: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29370761/hepatitis-c-related-cryoglobulinemic-neuropathy-potential-role-of-oxcarbazepine-for-pain-control
#10
Rita Moretti, Paola Caruso, Matteo Dal Ben, Silvia Gazzin, Claudio Tiribelli
BACKGROUND: Peripheral neuropathy is one most common, limiting and invalidating neurological symptom in subjects with hepatitis C virus and mixed cryoglobulinemia. Notably, the medical therapy proposed to eradicate HCV, can frequently exacerbate the painful neuropathy. Therefore, neuropathy therapies are insufficient and inadequate, and comprise immunosuppressive drugs, such as steroid or cyclosporine, intravenous immunoglobulin or plasma exchange. These have shown variable success in case reports, with a presumably temporary effect, but with major side effects...
January 25, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29369456/assessment-of-efficacy-and-safety-of-eslicarbazepine-acetate-for-the-treatment-of-trigeminal-neuralgia
#11
A Sanchez-Larsen, D Sopelana-Garay, I Diaz-Maroto, A B Perona-Moratalla, J Gracia-Gil, S García-Muñozguren, E Palazón-García, T Segura
BACKGROUND: Antiepileptic drugs are the first line treatment for trigeminal neuralgia (TN). Carbamazepine and oxcarbazepine are the most studied with well-known efficacy. Eslicarbazepine acetate is a third-generation antiepileptic drug that has not previously been evaluated for the treatment of TN. We aim to assess the efficacy, tolerability, and safety of eslicarbazepine for TN. DESIGN AND METHODS: Retrospective, open-label, multicentric, intention-to-treat study...
January 25, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29364494/oxcarbazepine-causes-neurocyte-apoptosis-and-developing-brain-damage-by-triggering-bax-bcl-2-signaling-pathway-mediated-caspase-3-activation-in-neonatal-rats
#12
Y Song, M Zhong, F-C Cai
OBJECTIVE: Anti-epileptic drugs (AEDs) are the main methods for treatment of neonatal seizures; however, a few AEDs may cause developing brain damage of neonate. This study aims to investigate effects of oxcarbazepine (OXC) on developing brain damage of neonatal rats. MATERIALS AND METHODS: Both of neonatal and adult rats were divided into 6 groups, including Control, OXC 187.5 mg/kg, OXC 281.25 mg/kg, OXC 375 mg/kg group, LEV and PHT group. Body weight and brain weight were evaluated...
January 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29362853/volumetric-absorptive-microsampling-as-an-alternative-tool-for-therapeutic-drug-monitoring-of-first-generation-anti-epileptic-drugs
#13
Sofie Velghe, Christophe P Stove
Dosage adjustment of anti-epileptic drugs by therapeutic drug monitoring (TDM) is very useful, especially for the first-generation anti-epileptic drugs (AEDs). Microsampling-the collection of small volumes of blood-is increasingly considered a valuable alternative to conventional venous sampling for TDM. Volumetric absorptive microsampling (VAMS) allows accurate and precise collection of a fixed volume of blood, eliminating the volumetric blood hematocrit bias coupled to conventional dried blood spot collection...
January 23, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29358420/comparative-efficacy-and-acceptability-of-antiepileptic-drugs-for-classical-trigeminal-neuralgia-a-bayesian-network-meta-analysis-protocol
#14
Zongshi Qin, Shang Xie, Zhi Mao, Yan Liu, Jiani Wu, Toshi A Furukawa, Joey S W Kwong, Jinhui Tian, Zhishun Liu
INTRODUCTION: Trigeminal neuralgia (TN) affects 4 to 28.9/100 000 people worldwide, and antiepileptic drugs such as carbamazepine and oxcarbazepine are the firstline treatment options. However, the efficacy and safety of other antiepileptic drugs remain unclear due to insufficient direct comparisons. OBJECTIVE: To compare the efficacy and acceptability of all currently available antiepileptic agents for the treatment of patients with classical TN. METHODS: We will search the PubMed, EMBASE, Cochrane Library and Web of Science databases for unpublished or undergoing research listed in registry platforms...
January 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29350111/sustained-viral-suppression-with-co-administration-of-oxcarbazepine-and-dolutegravir
#15
Manar M Kandil, Melissa E Badowski, Christopher A Schriever
Co-administration of dolutegravir and oxcarbazepine has been reported to reduce levels of dolutegravir and therefore is contraindicated due to insufficient data to make dosing recommendations. We present eight cases in which patients with human immunodeficiency virus (HIV) inadvertently received oxcarbazepine while concurrently receiving 50 mg of dolutegravir daily as part of their antiretroviral therapy. Upon further evaluation, lab results revealed that despite the risk of decreased levels of dolutegravir due to possible oxcarbazepine enzyme induction, patients maintained at or near virologic suppression (viral load <20 copies/ml)...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29337102/polymeric-microspheres-of-okra-mucilage-and-alginate-for-the-controlled-release-of-oxcarbazepine-in-vitro-in-vivo-evaluation
#16
Shazia Akram Ghumman, Sajid Bashir, Sobia Noreen, Abdul Muqeet Khan, Sualeha Riffat, Mateen Abbas
Oxcarbazepine-loaded alginate/okra pods mucilage microspheres were prepared through inotropic gelation technique for the sustained release of oxcarbazepine. The drug encapsulating efficiency of these microspheres was found 76.22 ± 0.01% to 90.57 ± 0.02% and their average particle sizes were 496 μm ± 0.41 to 692 μm ± 0.22. These microspheres were characterized in terms of swelling capacity, FTIR, DSC and SEM analysis. The in vitro drug release from these microspheres was followed sustained release (Korsemeyer - Peppas model) pattern (R2 = 0...
January 11, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29322880/reversible-splenial-lesion-syndrome-due-to-oxcarbazepine-withdrawal-case-report-and-literature-review
#17
Chaoyang Jing, Lichao Sun, Zhuo Wang, Chaojia Chu, Weihong Lin
Background Reversible splenial lesion syndrome is a distinct entity radiologically characterized by a reversible lesion in the splenium of the corpus callosum. According to previous reports, this condition may be associated with antiepileptic drug use or withdrawal. We herein report a case of reversible splenial lesion syndrome associated with oxcarbazepine withdrawal. Case Report A 39-year-old man presented with an 8-year history of epileptic seizures. During the previous 3 years, he had taken oxcarbazepine irregularly...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29318116/expression-of-multidrug-resistance-genes-in-peripheral-blood-of-patients-with-refractory-epilepsy-and-the-reverse-effect-of-oxcarbazepine-on-its-expression
#18
Jinming Ji, Gang Li, Yunxia Ma, Shuangshuang Pan, Rongrong Yuan
Background: We aimed to investigate the expression levels of multidrug resistance gene 1 (MDR1), multidrug resistance-associated protein 1 (MRP1) and multidrug resistance P-glycoprotein (P-gp) in peripheral blood of patients with refractory epilepsy. Methods: Patients with epilepsy (n=24) and those with refractory epilepsy (n=24) were selected, and 30 normal volunteers were enrolled as control. The expression level of MDR1 genes was detected using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR)...
January 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29302292/dental-implants-placement-in-paranoid-squizofrenic-patient-with-obsessive-compulsive-disorder-a-case-report
#19
Lizett Castellanos-Cosano, José-Ramón Corcuera-Flores, María Mesa-Cabrera, José Cabrera-Domínguez, Daniel Torres-Lagares, Guillermo Machuca-Portillo
Background: Paranoid schizophrenia is a mental illness that involves no observable anatomical alteration. Main characteristic affects the personality of the individual, as well as areas of his own psychology. Case Report: A 33-year-old man with paranoid schizophrenia and obsessive-compulsive disorder in treatment with Haloperidol, Oxcarbazepine, Olanzapine and Seroquel is presented. Dental exploration showed widespread decay mostly cervical with numerous root fragments, agenesis of lateral incisors, impacted wisdom teeth, missing teeth and malocclusion...
November 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29301160/-pharmacotherapy-of-vestibular-disorders-nystagmus-and-cerebellar-disorders
#20
K Feil, N Böttcher, O Kremmyda, C Muth, J Teufel, A Zwergal, T Brandt, M Strupp
There are currently different groups of drugs for the pharmacotherapy of vertigo, nystagmus and cerebellar disorders: antiemetics; anti-inflammatories, antimenieres, and antimigraineous medications and antidepressants, anticonvulsants, aminopyridines as well as acetyl-DL-leucine. In acute unilateral vestibulopathy, corticosteroids improve the recovery of peripheral vestibular function, but currently there is not sufficient evidence for a general recommendation. There is insufficient evidence to support the view that 16 mg t...
January 2018: Laryngo- Rhino- Otologie
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