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oxcarbazepine

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https://www.readbyqxmd.com/read/29658094/modification-of-polydopamine-coated-fe-3-o-4-nanoparticles-with-multi-walled-carbon-nanotubes-for-magnetic-%C3%AE-dispersive-solid-phase-extraction-of-antiepileptic-drugs-in-biological-matrices
#1
Ruiqi Zhang, Siming Wang, Ye Yang, Yulan Deng, Di Li, Ping Su, Yi Yang
In this study, multi-walled carbon nanotubes were coated on the surface of magnetic nanoparticles modified by polydopamine. The synthesized composite was characterized and applied to magnetic-μ-dispersive solid-phase extraction of oxcarbazepine (OXC), phenytoin (PHT), and carbamazepine (CBZ) from human plasma, urine, and cerebrospinal fluid samples prior to analysis by a high-performance liquid chromatography-photodiode array detector. The extraction parameters were investigated and the optimum condition was obtained when the variables were set to the following: sorbent type, Fe3 O4 @polyDA-MWCNTs (length < 2 μm); sample pH, 6; amount of sorbent, 15 mg; sorption time, 1...
April 16, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29653413/influence-of-propafenone-on-the-anticonvulsant-activity-of-various-novel-antiepileptic-drugs-in-the-mouse-maximal-electroshock-model
#2
Kinga K Borowicz-Reutt, Monika Popławska, Monika Banach, Dorota Wróblewska
BACKGROUND: The main mechanism of action of propafenone (antiarrhythmic drug) involves the inhibition of the fast inward sodium current during phase 0 of the action potential. Sodium channel-blocking activity is also characteristic for some antiepileptic drugs. Therefore, it could be assumed that propafenone may also affect seizures. In the present study, we evaluated the effect of propafenone on the protective effect of oxcarbazepine, lamotrigine, topiramate and pregabalin against the maximal electroshock-induced seizures in mice...
November 23, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29629814/association-between-hla-b-15-02-and-oxcarbazepine-induced-cutaneous-adverse-reaction-a-meta-analysis
#3
Yiwei Liu, Yuncui Yu, Xiaolu Nie, Libo Zhao, Xiaoling Wang
AIM: HLA-B*15:02 has been demonstrated as a key risk factor for carbamazepine-induced severe cutaneous adverse reaction (sCAR), especially in Asian population. Oxcarbazepine (OXC) is a drug that has a similar structure of carbamazepine. However, the relationship between HLA-B*15:02 and induced cutaneous adverse reaction (cADR) remains unknown. This study aims to analyze this association in the published literature. METHOD: After filtering studies, eight studies were finally included for meta-analysis, including 32 sCAR cases, 112 mild cutaneous adverse reaction (mcADR) cases, 281 OXC tolerant control and 946 population control cases...
April 9, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29625812/scn2a-mutation-in-an-infant-presenting-with-migrating-focal-seizures-and-infantile-spasm-responsive-to-a-ketogenic-diet
#4
Da-Jyun Su, Jyh-Feng Lu, Li-Ju Lin, Jao-Shwann Liang, Kun-Long Hung
SCN2A mutations have been identified in various encephalopathy phenotypes, ranging from benign familial neonatal-infantile seizure (BFNIS) to more severe forms of epileptic encephalopathy such as Ohtahara syndrome or epilepsy of infancy with migrating focal seizure (EIMFS). Thus far, no particularly effective treatment is available for severe epileptic encephalopathy caused by SCN2A mutations in children. We present the case of a boy who developed seizures on the third day of life and received a diagnosis of EIMFS based on his clinical presentations and electroencephalography reports...
April 3, 2018: Brain & Development
https://www.readbyqxmd.com/read/29621123/development-and-validation-of-a-u-hplc-ms-ms-method-for-the-concurrent-measurement-of-gabapentin-lamotrigine-levetiracetam-monohydroxy-derivative-mhd-of-oxcarbazepine-and-zonisamide-concentrations-in-serum-in-a-clinical-setting
#5
Michael J Palte, Sankha S Basu, Jameson L Dahlin, Ralitsa Gencheva, Donald Mason, Petr Jarolim, Athena K Petrides
BACKGROUND: Therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) is often necessary to prevent associated destructive toxicities. Tandem mass spectrometry (MS/MS) with stable-isotope-labeled (SIL) internal standards (ISs) is considered the gold standard for the measurement of AEDs. This study presents the development and validation of a clinical ultra-performance liquid chromatography (U-HPLC)-MS/MS method for the concurrent measurement of gabapentin, lamotrigine, levetiracetam, monohydroxy derivative (MHD) of oxcarbazepine, and zonisamide in human serum...
April 3, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29618181/preparation-of-interface-assembled-carbonyl-reductase-and-its-application-in-the-synthesis-of-s-licarbazepine-in-toluene-tris-hcl-buffer-biphasic-system
#6
Zhimin Ou, Jiahui Xu, Lihua Du, Lan Tang, Yangping Niu, Jian Cui
In this study, interface-assembled carbonyl reductase (IACR) is prepared and used in the synthesis of S-licarbazepine in a toluene/Tris-HCl biphasic system. The carbonyl reductase (CR) is conjugated with polystyrene to form a surfactant-like structure at the interface of the toluene/Tris-HCl biphasic system. The interface-assembled efficiency of IACR reached 83% when the CR (180 U/mg) and polystyrene concentration were 0.8 g/l and 3.75 g/l, respectively. The conversion reached 95.6% and the enantiometric excess of S-licarbazepine was 98...
April 6, 2018: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29610167/-hla-a-31-01-and-oxcarbazepine-induced-dress-in-a-patient-with-seizures-and-complete-dcx-deletion
#7
Hyun Kim, Laura Chadwick, Yasir Alzaidi, Jonathan Picker, Annapurna Poduri, Shannon Manzi
Oxcarbazepine is an antiepileptic drug (AED) commonly used as a first-line treatment option for focal epilepsy. Several AEDs, including carbamazepine, oxcarbazepine, and phenytoin are associated with various delayed-hypersensitivity reactions such as drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, or toxic epidermal necrolysis. The Food and Drug Administration-approved label for oxcarbazepine currently presents information regarding a pharmacogenomic association with the HLA antigen allele HLA-B*15:02 and hypersensitivity reactions in certain ancestry groups with a high incidence of this allele...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29594147/oxcarbazepine-therapy-for-complete-central-diabetes-insipidus
#8
Basmah Abdallah, Spencer Hodgins, Daniel Landry, Michael O'shea, Gregory Braden
Oxcarbazepine and carbamazepine cause hyponatremia by unknown mechanisms. We describe a patient with complete central diabetes insipidus and seizures who developed worsening hyponatremia when her dose of oxcarbazepine was increased. The patient maintained a normal serum sodium level and has had appropriately concentrated urine for 5 years on just oxcarbazepine, despite undetectable antidiuretic hormone (ADH) levels. This suggests that oxcarbazepine (or one of its metabolites) may stimulate collecting tubule V2 receptor-G protein complex independent of ADH, resulting in increased renal tubular water reabsorption...
January 2018: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/29576201/micellar-hplc-method-for-the-simultaneous-determination-of-three-anticonvulsant-drugs-in-dosage-forms-and-biological-fluids-application-to-dissolution-rate-testing
#9
F Belal, F Ibrahim, Z A Sheribah, H Alaa
This work describes a micellar liquid chromatographic method which was developed and validated to determine simultaneously three structurally-related antiepileptic drugs; namely carbamazepine (CMZ), oxcarbazepine (OCZ) and eslicarbazepine acetate (ECZ). The analysis was achieved using a phenyl column (250mm×4.6mm i.d., 5μm particle size), a mobile phase consisting of a mixture of 0.3% triethylamine and 10% n-butanol in a solution of 0.05M sodium dodecyl sulphate adjusted to pH 7.0 using 0.02M orthophosphoric acid...
March 22, 2018: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/29571152/comparative-efficacy-of-unique-antiepileptic-drug-regimens-in-focal-epilepsy-an-exploratory-study
#10
Alexander W Legge, Kamil Detyniecki, Asif Javed, Lawrence J Hirsch, Kenneth Kato, Richard Buchsbaum, Baibing Chen, Hyunmi Choi
OBJECTIVE: To compare efficacy of unique antiepileptic drug (AED) polytherapy regimens among patients with focal epilepsy. METHODS: From a longitudinal study of AED treatment, we identified patients with active focal epilepsy who had attempted at least two unique AED regimens (mono-, duo-, or tri-therapy). Efficacy was defined as the presence of at least one six-month period of continuous seizure freedom during exposure to a regimen. To control for individual variations in response and epilepsy severity, we used within-patient comparison approaches, in which we: 1) compared head-to-head unique regimens tried within the same patients; 2) compared one regimen versus aggregate of other regimens attempted in that patient; and 3) compared aggregated monotherapy versus polytherapy regimens...
March 10, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29569740/the-medication-risk-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-asians-the-major-drug-causality-and-comparison-to-the-usa-fda-label
#11
Yu-Hsin Wang, Chun-Bing Chen, Wichittra Tassaneeyakul, Yoshiro Saito, Michiko Aihara, Siew Eng Choon, Haur Yueh Lee, Mimi Mee Chang, Francisca D Roa, Cheng-Wei Wu, Jing Zhang, Nontaya Nakkam, Parinya Konyoung, Yoshimi Okamoto-Uchida, Christina Man-Tung Cheung, Jin-Wen Huang, Chao Ji, Bo Cheng, Rosaline Chung-Yee Hui, Chia-Yu Chu, Yi-Ju Chen, Ching-Ying Wu, Chao-Kai Hsu, Tsu-Man Chiu, Hsin-Chun Ho, Jing-Yi Lin, Chih-Hsun Yang, Ya-Ching Chang, Shih-Chi Su, Chuang Wei Wang, Wen-Hung Chung
Specific ethnic genetic backgrounds associated with risk of Stevens-Johnson syndrome/toxic epidermal necrolysis(SJS/TEN) especially in Asians. However, there have been no large cohort, multiple-country epidemiological studies of medication risk related to SJS/TEN in Asian populations. Thus, we analyzed the registration databases from multiple Asian countries who were treated during 1998-2017. A total 1028 SJS/TEN cases were identified by ALDEN. Furthermore, those medications labeled by USFDA as carrying a risk of SJS/TEN were also compared to the common causes of SJS/TEN in Asian countries...
March 23, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29563858/eslicarbazepine-acetate-in-the-treatment-of-adults-with-partial-onset-epilepsy-an-evidence-based-review-of-efficacy-safety-and-place-in-therapy
#12
REVIEW
Simona Lattanzi, Francesco Brigo, Claudia Cagnetti, Alberto Verrotti, Gaetano Zaccara, Mauro Silvestrini
Introduction: Up to 30% of the patients diagnosed with epilepsy will continue suffering from seizures despite treatment with antiepileptic drugs, either in monotherapy or polytherapy. Hence, there remains the need to develop new effective and well-tolerated therapies. Aim: The objective of this article was to review the evidence for the efficacy and safety of eslicarbazepine acetate (ESL) as adjunctive treatment in adult patients with focal onset seizures. Evidence review: ESL is the newest, third-generation, single enantiomer member of the dibenzazepine family...
2018: Core Evidence
https://www.readbyqxmd.com/read/29559784/a-meta-analysis-of-randomized-controlled-trials-on-levetiracetam-in-the-treatment-of-pediatric-patients-with-epilepsy
#13
REVIEW
Lanlan Zhang, Chengzhong Wang, Wei Li
Objective: To evaluate clinical efficacy, safety, and tolerability of levetiracetam as mono- or adjunctive therapy in the treatment of children and adolescents with epilepsy. Materials and methods: We performed a meta-analysis of randomized controlled trials published from January 2007 to December 2016 in the databases Web of Science, Medline, Embase, Cochrane Library, and PubMed, Bing, Baidu, Google Scholar, Chinese National Knowledge Infrastructure (CNKI), and Wanfang Data...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29527636/possible-pharmacodynamic-and-pharmacokinetic-drug-drug-interactions-that-are-likely-to-be-clinically-relevant-and-or-frequent-in-bipolar-disorder
#14
REVIEW
Jose de Leon, Edoardo Spina
PURPOSE OF REVIEW: Patients with bipolar disorder are frequently treated with polypharmacy. This article should provide clinicians with an understanding of how polypharmacy can contribute to pharmacokinetic and pharmacodynamic drug-drug interactions (DDIs). RECENT FINDINGS: The pharmacokinetics and pharmacodynamics of lithium and other mood stabilizers (valproate, lamotrigine, carbamazepine, oxcarbazepine, and eslicarbazepine), antipsychotics, and selective serotonin reuptake inhibitors (SSRIs) were reviewed and summarized in the first four tables describing their pharmacokinetic and pharmacodynamic mechanisms...
March 12, 2018: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29524819/insights-into-influencing-factor-degradation-mechanism-and-potential-toxicity-involved-in-aqueous-ozonation-of-oxcarbazepine-chem46939r1
#15
Tao Wang, Zhen-Xing Huang, Heng-Feng Miao, Wen-Quan Ruan, Xiao-Ping Ji, Fu-Bao Sun, Ming-Xing Zhao, Hong-Yan Ren
Oxcarbazepine (OXC), as a potent antiepileptic drug, is widely used in recent years, but its residue is potentially harmful to the environment. Although ozonation is a high-efficient technology for chemical oxidation during water treatment, it cannot completely mineralize organic matters, but partially transforms them into some unidentified by-products. In order to provide more insight into OXC ozonation process, the influencing factor, transformation mechanism and potential toxicity were comprehensively investigated in this study...
February 9, 2018: Chemosphere
https://www.readbyqxmd.com/read/29498493/effect-of-antiepileptic-drug-comedication-on-lamotrigine-concentrations
#16
Mila Lovrić, Ivana Čajić, Željka Petelin Gadže, Iva Klarica Domjanović, Nada Božina
AIM: To estimate the effect size of concomitant antiepileptic therapy on the concentrations of lamotrigine, a drug often prescribed in combination with other antiepileptic drugs (AED), which can act as enzyme inducers or inhibitors. METHODS: A total of 304 patients with epilepsy, aged 18-70 years, were divided into a lamotrigine monotherapy group and groups receiving lamotrigine with AEDs that act as enzyme inducers, enzyme inhibitors, or both. We compared lamotrigine monotherapy serum concentrations with those where lamotrigine was administered with a metabolic inhibitor valproate, metabolic inducers carbamazepine, oxcarbazepine, phenobarbital, phenytoin, or topiramate, and both an inducer and an inhibitor...
February 28, 2018: Croatian Medical Journal
https://www.readbyqxmd.com/read/29496230/role-of-voltage-gated-sodium-channel-blockers-in-the-treatment-of-chronic-pain-potential-uses-in-clinical-practice-based-on-available-evidence
#17
A Alcántara Montero, C I Sánchez Carnerero
Once patients have failed first line therapy, there is an apparent lack of knowledge on how to proceed with choosing subsequent therapy. To choose amongst alternative agents, an understanding of pharmacology, pharmacokinetics, and available evidence in targeting various pain conditions is necessary. This article focuses on the use of the carboxamide class of voltage-gated sodium channel blockers (carbamazepine, oxcarbazepine, eslicarbazepine acetate) for adjunct pain medication management; including research updates in pharmacology, pharmacokinetics, and evidence for pain along on this therapeutic group with promising future areas of research...
February 26, 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29487964/-use-of-antiepileptic-drugs-during-breastfeeding-what-do-we-tell-the-mother
#18
M Crettenand, A O Rossetti, T Buclin, U Winterfeld
BACKGROUND: Knowledge about the passage of various antiepileptic drugs into breast milk and its consequences for the infant is limited. Faced with this uncertainty, breastfeeding is often discouraged for these patients. The aim of this study was to comprehensively review the available data regarding antiepileptic drugs during breastfeeding, to compare these data with information provided by the summary of product characteristics (SmPCs), and to provide recommendations for the use of these drugs in breastfeeding women...
February 27, 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/29477837/a-survey-of-antiepileptic-drug-responses-identifies-drugs-with-potential-efficacy-for-seizure-control-in-wolf-hirschhorn-syndrome
#19
Karen S Ho, Leah M Markham, Hope Twede, Amanda Lortz, Lenora M Olson, Xiaoming Sheng, Cindy Weng, E Robert Wassman, Tara Newcomb, E Robert Wassman, John C Carey, Agatino Battaglia
Seizures are present in over 90% of infants and children with Wolf-Hirschhorn syndrome (WHS). When present, they significantly affect quality of life. The goal of this study was to use caregiver reports to describe the comparative efficacies of commonly used antiepileptic medications in a large population of individuals with WHS. A web-based, confidential caregiver survey was developed to capture seizure semiology and a chronologic record of seizure treatments as well as responses to each treatment. Adverse events for each drug were also cataloged...
February 22, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29467570/reference-ranges-for-antiepileptic-drugs-revisited-a-practical-approach-to-establish-national-guidelines
#20
Arne Reimers, Jon Andsnes Berg, Margrete Larsen Burns, Eylert Brodtkorb, Svein I Johannessen, Cecilie Johannessen Landmark
Background and objective: Laboratories sometimes use different reference ranges for the same antiepileptic drug (AED), particularly for new and poorly investigated drugs. This may contribute to misunderstandings, concerns or inappropriate dose changes, which in turn may affect therapeutic effect, drug safety or treatment adherence. Therefore, the Norwegian Association of Clinical Pharmacology wished to update and harmonize the reference ranges for AEDs and establish national guidelines for Norway...
2018: Drug Design, Development and Therapy
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