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Osteoinduction

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https://www.readbyqxmd.com/read/29035127/healing-potential-of-nanohydroxyapatite-gelatin-and-fibrin-platelet-glue-combination-as-tissue-engineered-scaffolds-in-radial-bone-defects-of-rats
#1
Abdolhamid Meimandi-Parizi, Ahmad Oryan, Hojjat Gholipour
Different biomaterials have been used in orthopedic surgery. Evaluation of biomaterials for bone healing promotion has been a wide area of research of the orthopedic field. Sixty critical size defects of 5 mm long were bilaterally created in the radial diaphysis of 30 rats. The animals were randomly divided into six equal groups as empty defect, autograft, nanohydroxyapatite (nHA), Gelatin (Gel)-nHA, Fibrin-platelet glue (FPG)-nHA and Gel-FPG-nHA groups (n = 10 in each group). Radiographs of each forelimb were taken postoperatively on the 1(st) day and then at the 28(th) and 56(th) days post injury...
October 16, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/29032745/strategic-directions-in-biomimetics-and-osteoinduction
#2
Pamela Habibovic
Strategic Directions in Biomimetics and Osteoinduction.
October 15, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29031993/the-gdf5-mutant-bb-1-enhances-the-bone-formation-induced-by-an-injectable-plga-fiber-reinforced-brushite-forming-cement-in-a-sheep-defect-model-of-lumbar-osteopenia
#3
Francesca Gunnella, Elke Kunisch, Stefan Maenz, Victoria Horbert, Long Xin, Joerg Mika, Juliane Borowski, Sabine Bischoff, Harald Schubert, Andre Sachse, Bernhard Illerhaus, Jens Günster, Jörg Bossert, Klaus D Jandt, Frank Plöger, Raimund W Kinne, Olaf Brinkmann, Matthias Bungartz
BACKGROUND CONTEXT: Targeted delivery of osteoinductive bone morphogenetic proteins (BMPs; e.g., GDF5) in bioresorbable calcium phosphate cement (CPC), potentially suitable for vertebroplasty/kyphoplasty of osteoporotic vertebral fractures, may be required to counteract augmented local bone catabolism and support complete bone regeneration. The biologically optimized GDF5 mutant BB-1 may represent an attractive drug candidate for this purpose. PURPOSE: The aim of the current study was to test an injectable, poly (l-lactide-co-glycolide) acid (PLGA)-fiber reinforced, brushite-forming cement (CPC) containing low-dose BB-1 in a sheep lumbar osteopenia model...
October 12, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29025670/bone-regeneration-biomaterials-as-local-delivery-systems-with-improved-osteoinductive-properties
#4
REVIEW
Victor Martin, Ana Bettencourt
Bone is a mineralized conjunctive tissue, with a unique trauma healing capability. However, the replacement or regeneration of lost bone is not always successful and becomes more difficult the wider the bone defect. A significant growth in the demand for orthopedic and maxillofacial surgical procedures as a result of population aging and increase in chronic diseases as diabetes is a fact and successful approaches for bone regeneration are still needed. Until today, autogenous bone graft continues to be the best solution even with important limitations, as quantity and the requirement of a donator area...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29025652/high-activity-chitosan-nano-hydroxyapatite-zoledronic-acid-scaffolds-for-simultaneous-tumor-inhibition-bone-repair-and-infection-eradication
#5
Yao Lu, Mei Li, Lihua Li, Shuzhen Wei, Xiaoming Hu, Xiaolan Wang, Guiqiu Shan, Yu Zhang, Hong Xia, Qingshui Yin
Implanted biomaterials combined tumor inhibition and bone repair property are urgently needed to address the huge bone destruction and the high local recurrence following primary surgery in bone tumor therapy. In this work, a high-activity chitosan/nano hydroxyapatite (CS/nHA) scaffold containing zoledronic acid (CS/nHA/Zol) was prepared with a facile method. The prepared CS/nHA/Zol scaffolds exhibited excellent tumor inhibition property towards giant cell tumor of bone (GCT) in vitro through inducing cells apoptosis by up-regulating pro-apoptosis genes expression and reducing the osteoclastic activity of tumor cells by down-regulating osteoclastic genes...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29022110/monitoring-bone-tissue-engineered-bte-constructs-based-on-the-shifting-metabolism-of-differentiating-stem-cells
#6
Aaron D Simmons, Vassilios I Sikavitsas
Ever-increasing demand for bone grafts necessitates the realization of clinical implementation of bone tissue engineered constructs. The predominant hurdle to implementation remains to be securing FDA approval, based on the lack of viable methods for the rigorous monitoring of said constructs. The study presented herein details a method for such monitoring based on the shifting metabolism of mesenchymal stem cells (MSCs) as they differentiate into osteoblasts. To that end, rat MSCs seeded on 85% porous spunbonded poly(L-lactic acid) scaffolds were cultured in flow perfusion bioreactors with baseline or osteoinductive media, and levels of key physio-metabolic markers (oxygen, glucose, osteoprotegerin, and osteocalcin) were monitored throughout culture...
October 11, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29018937/local-effect-of-zoledronic-acid-on-new-bone-formation-in-posterolateral-spinal-fusion-with-demineralized-bone-matrix-in-a-murine-model
#7
Pawel Zwolak, Jan Farei-Campagna, Thorsten Jentzsch, Brigitte von Rechenberg, Clément M Werner
BACKGROUND: Posterolateral spinal fusion is a common orthopaedic surgery performed to treat degenerative and traumatic deformities of the spinal column. In posteriolateral spinal fusion, different osteoinductive demineralized bone matrix products have been previously investigated. We evaluated the effect of locally applied zoledronic acid in combination with commercially available demineralized bone matrix putty on new bone formation in posterolateral spinal fusion in a murine in vivo model...
October 10, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29018836/one-step-fabrication-of-bone-morphogenetic-protein-2-gene-activated-porous-poly-l-lactide-scaffold-for-bone-induction
#8
Jingwen Xue, Hang Lin, Allison Bean, Ying Tang, Jian Tan, Rocky S Tuan, Bing Wang
Bone morphogenetic protein 2 (BMP2) is an efficacious inducer for the osteogenesis of mesenchymal stem cells (MSCs). Conventional applications of BMP2 have involved either the direct incorporation of BMP2 protein or ex vivo BMP2 gene transfer into stem cells prior to their transplantation. These approaches are able to promote bone formation to some extent; however, they are hampered by either the lack of stability and sustainability of BMP2 protein or the time-consuming and cost-prohibitive in vitro cell culture procedure...
December 15, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/28976356/creating-hierarchical-porosity-hydroxyapatite-scaffold-with-osteoinduction-by-three-dimensional-printing-and-microwave-sintering
#9
Xuan Pei, Liang Ma, Boqing Zhang, Jianxun Sun, Yong Sun, Yujiang Fan, Zhongru Gou, Changchun Zhou, Xingdong Zhang
Hierarchical porosity, which includes micropores and macropores in scaffolds, contributes to important multiple biological functions for tissue regeneration. This paper introduced a two-step method of combining three-dimensional printing (3DP) and microwave sintering to fabricate two-level hierarchical porous scaffolds. The results showed that 3D printing made the macroporous structure well-controlled and microwave sintering generated micropores on macropore surface. The resulting hierarchical macro-/micro-porous hydroxyapatite scaffold induced bone formation following intramuscular implantation...
October 4, 2017: Biofabrication
https://www.readbyqxmd.com/read/28960963/sr-ha-graft-poly-%C3%AE-benzyl-l-glutamate-nanocomposite-microcarriers-controllable-sr-2-release-for-accelerating-osteogenenisis-and-bony-nonunion-repair
#10
Long Gao, Zhongyue Huang, Shifeng Yan, Kunxi Zhang, Shenghua Xu, Guifei Li, Lei Cui, Jingbo Yin
The microcarrier system offers an attractive method for cellular amplification and phenotype enhancement in the field of bone tissue engineering. However, it remains a challenge to fabricate porous microcarriers with osteoinductive activity for speedy and high-quality osseointegration in regeneration of serious complication of bone fracture, like nonunion. Here, we present a facile method for the first time manufacture microcarriers with osteogenic effects and properties based on well controlled and long-term Sr(2+) release...
October 10, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28960906/hplc-ms-ms-a-potential-method-to-track-the-in-vivo-degradation-of-zein-based-biomaterial
#11
Hua-Jie Wang, Shunji Kato, Yue Zhang, Kiyotaka Nakagawa, Teruo Miyazawa, Jin-Ye Wang
Given the inadequacies of existing clinic tracking strategies, such as isotopic tracer techniques, one of the major thrusts in protein-based tissue engineering substitutes prior to use in clinic is to develop a safe technique that can effectively track their degradation in vivo. Keeping in view the possible application of a natural polymer, zein as a novel bone substitute, with the advantages of good bio-compatibility, bio-degradability and outstanding mechanical properties, we attempted here to construct a HPLC-MS/MS method to track the in vivo degradation of zein porous scaffold...
September 29, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28960767/gellan-gum-hydroxyapatite-composite-hydrogels-for-bone-tissue-engineering
#12
Marianthi G Manda, Lucilia P da Silva, Mariana T Cerqueira, Diana R Pereira, Mariana B Oliveira, João F Mano, Alexandra P Marques, Joaquim M Oliveira, Vitor M Correlo, Rui L Reis
Osteoinductive biomaterials represent a promising approach to advance bone grafting. Despite promising, the combination of sustained biodegradability, mechanical strength and biocompatibility in a unique biomaterial that can also support cell performance and bone formation in vivo is demanding. Herein, we developed gellan gum (GG)-hydroxyapatite (HAp) spongy-like hydrogels to mimic the organic (GG) and inorganic (HAp) phases of the bone. HAp was successfully introduced within the GG polymeric networks, as determined by FTIR and XRD, without compromising the thermostability of the biomaterials, as showed by TGA...
September 29, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28953153/the-elution-kinetics-of-bmp-2-bmp-4-and-bmp-7-from-a-commercial-human-demineralized-bone-matrix-putty
#13
William S Pietrzak, Saba N Ali
Bone morphogenetic proteins (BMPs) are associated with bone extracellular matrix and impart osteoinductive properties to demineralized bone matrix (DBM) grafts. The first step of the osteoinductive process is BMP release from DBM in situ; however, this has not been characterized for human DBM. The authors investigated the release of BMPs 2, 4, and 7 from a clinical human DBM putty (Bonus II DBM, Biomet Inc, Warsaw, IN). The DBM was placed in Sorensen buffer and the BMP concentrations in the Sorensen buffer and guanidine extracts of the DBM were measured concurrently by enzymelinked immunosorbant assay for up to 7 days...
September 25, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28952824/maxillary-sinus-lift-using-osteoinductive-simvastatin-combined-with-%C3%AE-tcp-versus-%C3%AE-tcp-a-comparative-pilot-study-to-evaluate-simvastatin-enhanced-and-accelerated-bone-formation
#14
Ayman Gouda, Eman Helal, Sherif Ali, Saleh Bakry, Salah Yassin
PURPOSE: The aim of this study was to evaluate available bone quality and quantity after performing sinus augmentation using simvastatin/β-TCP combination versus β-TCP alone. MATERIALS AND METHODS: This study included eight sinus lift procedures conducted on six patients. The sinuses were divided into two equal groups. The patients were recalled one, two weeks two, five, nine months post-operatively for post-operative evaluation. Radiographic evaluation involved cone beam computed tomography (CBCT) radiographs taken for every patient one week and nine months post-operatively to evaluate the changes in bone height, while histomorphometric evaluation involved transcortical bone biopsies taken after nine months during the second-stage surgery for implant placement...
September 27, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28946792/calvarial-bone-regeneration-is-enhanced-by-sequential-delivery-of-fgf-2-and-bmp-2-from-layer-by-layer-coatings-with-a-biomimetic-calcium-phosphate-barrier-layer
#15
Gloria Gronowicz, Emily Jacobs, Tao Peng, Li Zhu, Marja Hurley, Liisa T Kuhn
A drug delivery coating for synthetic bone grafts has been developed to provide sequential delivery of multiple osteoinductive factors to better mimic aspects of the natural regenerative process. The coating is composed of a biomimetic calcium phosphate (bCaP) layer that is applied to a synthetic bone graft and then covered with a poly-L-Lysine/poly-L-Glutamic acid polyelectrolyte multilayer (PEM) film. Bone morphogenetic protein-2 (BMP-2) was applied prior to the coating process directly on the synthetic bone graft and then bCaP-PEM was deposited followed by adsorption of fibroblast growth factor-2 (FGF-2) into the PEM layer...
September 25, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28946646/impact-of-surface-potential-on-apatite-formation-in-ti-alloys-subjected-to-acid-and-heat-treatments
#16
Seiji Yamaguchi, Hideki Hashimoto, Ryusuke Nakai, Hiroaki Takadama
Titanium metal (Ti) and its alloys are widely used in orthopedic and dental fields. We have previously shown that acid and heat treatment was effective to introduce bone bonding, osteoconduction and osteoinduction on pure Ti. In the present study, acid and heat treatment with or without initial NaOH treatment was performed on typical Ti-based alloys used in orthopedic and dental fields. Dynamic movements of alloying elements were developed, which depended on the kind of treatment and type of alloy. It was found that the simple acid and heat treatment enriched/remained the alloying elements on Ti-6Al-4V, Ti-15Mo-5Zr-3Al and Ti-15Zr-4Nb-4Ta, resulting in neutral surface charges...
September 24, 2017: Materials
https://www.readbyqxmd.com/read/28944060/one-ion-to-rule-them-all-combined-antibacterial-osteoinductive-and-anticancer-properties-of-selenite-incorporated-hydroxyapatite
#17
Vuk Uskoković, Maheshwar Adiraj Iyer, Victoria M Wu
Although hydroxyapatite (HAp) has been doped with dozens of different ions, the quest for an ion imparting a combination of properties conducive to bone healing is still ongoing. Because of its protean potency and the similarity in size and shape to the phosphate tetrahedron, selenite ion presents a natural ionic substitute in HAp. The incorporation of selenite into synthetic HAp using two different methods - co-precipitation and ion-exchange sorption - was studied for its effect on crystal properties and on a triad of biological responses: antibacterial, anticancer and osteoinductive...
2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/28943430/microrna-21-promotes-osteogenesis-of-bone-marrow-mesenchymal-stem-cells-via-the-smad7-smad1-5-8-runx2-pathway
#18
Xiaoyan Li, Lijia Guo, Yitong Liu, Yingying Su, Yongmei Xie, Juan Du, Jian Zhou, Gang Ding, Hao Wang, Yuxing Bai, Yi Liu
Bone marrow mesenchymal stem cells (BMMSCs) are pluripotent stem cells, and the osteogenic differentiation of BMMSCs has been drawing attention for a long time. Bone formation is regulated by numerous molecular and cellular signaling pathways, and the differentiation of BMMSCs is controlled by a well-defined genetic program. In the present study, we isolated BMMSCs from the bone cavities of wild-type (WT) and microRNA-21 knock-out (miR-21-KO) mice and found that miR-21 was significantly upregulated during the osteogenic differentiation of BMMSCs...
November 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28942129/bone-regeneration-with-micro-nano-hybrid-structured-biphasic-calcium-phosphate-bioceramics-at-segmental-bone-defect-and-the-induced-immunoregulation-of-mscs
#19
Yu Zhu, Kun Zhang, Rui Zhao, Xingjiang Ye, Xuening Chen, Zhanwen Xiao, Xiao Yang, Xiangdong Zhu, Kai Zhang, Yujiang Fan, Xingdong Zhang
Adequate bone regeneration has been difficult to achieve at segmental bone defects caused by disease. The surface structure and phase composition of calcium phosphate bioceramic are crucial for its bioactivity and osteoinductivity. In the present study, biphasic calcium phosphate (BCP) bioceramics composed of micro-whiskers and nanoparticles hybrid-structured surface (hBCP) were fabricated via a hydrothermal reaction. The in vivo long bone defect model of beagle dogs implanted with hBCP bioceramics achieved a higher quality regenerated bone as compared to the traditional smooth-surface BCP control group...
September 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28938197/a-collagen-membrane-containing-osteogenic-protein-1-facilitates-bone-regeneration-in-a-rat-mandibular-bone-defect
#20
Manami Ozaki, Tadahiro Takayama, Takanobu Yamamoto, Yasumasa Ozawa, Mayu Nagao, Natsuko Tanabe, Akira Nakajima, Naoto Suzuki, Masao Maeno, Seiichi Yamano, Shuichi Sato
OBJECTIVES: Osteogenic protein-1 (OP-1) has shown osteoinductive activities and is useful for clinical treatments, including bone regeneration. Regenerative procedures using a bioabsorbable collagen membrane (BCM) are well established in periodontal and implant dentistry. We evaluated the subsequent effects of the BCM in combination with OP-1 on bone regeneration in a rat mandibular circular critical-sized bone defect in vivo. DESIGN: We used 8 rats that received surgery in both sides of the mandible, and created the total 16 defects which were divided into 4 groups: Group 1; no treatment, as a control, Group 2; BCM alone, Group 3; BCM containing low dose 0...
September 8, 2017: Archives of Oral Biology
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