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Osteoinduction

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https://www.readbyqxmd.com/read/28731486/demineralized-dentin-and-enamel-matrices-as-suitable-substrates-for-bone-regeneration
#1
Nina Bono, Paolo Tarsini, Gabriele Candiani
BACKGROUND: In recent decades, tooth derivatives such as dentin (D) and enamel (E) have been considered as potential graft biomaterials to treat bone defects. This study aimed to investigate the effects of demineralization on the physical-chemical and biological behavior of D and E. METHODS: Human D and E were minced into particles (Ø<1 mm), demineralized and sterilized. Thorough physical-chemical and biochemical characterizations of native and demineralized materials were performed by SEM and EDS analysis and ELISA kits to determine mineral, collagen type I and BMP-2 contents...
July 20, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/28717129/3d-printed-scaffolds-of-calcium-silicate-doped-%C3%AE-tcp-synergize-with-co-cultured-endothelial-and-stromal-cells-to-promote-vascularization-and-bone-formation
#2
Yuan Deng, Chuan Jiang, Cuidi Li, Tao Li, Mingzheng Peng, Jinwu Wang, Kerong Dai
Synthetic bone scaffolds have potential application in repairing large bone defects, however, inefficient vascularization after implantation remains the major issue of graft failure. Herein, porous β-tricalcium phosphate (β-TCP) scaffolds with calcium silicate (CS) were 3D printed, and pre-seeded with co-cultured human umbilical cord vein endothelial cells (HUVECs) and human bone marrow stromal cells (hBMSCs) to construct tissue engineering scaffolds with accelerated vascularization and better bone formation...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28714236/effectiveness-of-tissue-engineered-three-dimensional-bioactive-graft-on-bone-healing-and-regeneration-an-in-vivo-study-with-significant-clinical-value
#3
Mostafa Shahrezaie, Ali Moshiri, Babak Shekarchi, Ahmad Oryan, Nicola Maffulli, Javad Parvizi
Several strategies have been used to promote bone repair; with many failing due to the lack of osteoinduction. We describe our approach for promoting bone healing that attempts to overcome prior shortcomings. First, we compared the role of different concentrations of Gelatin (Gel), nanostructured-hydroxyapatite (nHA), Simvastatin (Sim) and nHA-Sim particles on healing of small femoral bone defects in rabbits. The effective concentration of each of them was studied, and then a three-dimensional porous scaffold was designed using Gel, nHA and Sim which was then cross-linked with Genipin...
July 17, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28708200/periacetabular-bone-densitometry-after-total-hip-arthroplasty-with-highly-porous-titanium-cups-a-2-year-follow-up-prospective-study
#4
Leo Massari, Alessandro Bistolfi, Pier Paolo Grillo, Alda Borré, Gaetano Gigliofiorito, Carlotta Pari, Andrea Francescotto, Piermario Tosco, Davide Deledda, Laura Ravera, Araldo Causero
INTRODUCTION: Trabecular Titanium is an advanced cellular solid structure, composed of regular multiplanar hexagonal interconnected cells that mimic the morphology of the trabecular bone. This biomaterial demonstrated improved mechanical properties and enhanced osteoinduction and osteoconduction in several in vitro and in vivo studies. The aim of this study was to assess Trabecular Titanium osseointegration by measuring periacetabular changes in bone mineral density (BMD) with dual-emission X-ray absorptiometry (DEXA)...
July 1, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28707627/mussel-inspired-nano-building-block-assemblies-for-mimicking-extracellular-matrix-microenvironments-with-multiple-functions
#5
Zhenming Wang, Zhanrong Jia, Yanan Jiang, Pengfei Li, Lu Han, Xiong Lu, Fuzeng Ren, Ke-Feng Wang, Huipin Yuan
The assembly of nano-building blocks is an effective way to produce artificial extracellular matrix microenvironments with hierarchical micro/nano structures. However, it is hard to assemble different types of nano-building blocks, to form composite coatings with multiple functions, by traditional layer-by-layer (LbL) self-assembly methods. Inspired by the mussel adhesion mechanism, we developed polydopamine (PDA)-decorated bovine serum albumin nanoparticles (BSA-NPs) and nano-hydroxyapatite (nano-HA), and assembled them to form bioactive coatings with micro/nano structures encapsulating bone morphogenetic protein-2 (BMP-2)...
July 14, 2017: Biofabrication
https://www.readbyqxmd.com/read/28697075/posterolateral-bone-grafting-for-distal-tibia-nonunion
#6
Sanjit Konda, Hesham Saleh, Nina Fisher, Kenneth A Egol
INTRODUCTION: This video demonstrates the technique of posterolateral bone grafting with iliac crest bone graft for a distal tibial nonunion. METHODS: The patient is a 42-year-old man who is 6 months status post an open distal tibia-fibula fracture treated surgically, and presents complaints of persistent right ankle pain. The fracture site was tender to palpation, and 3 consecutive plain radiographs spaced 6 weeks apart demonstrated no evidence of callus formation...
August 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28688862/programmable-cells-of-monocytic-origin-as-a-source-of-osteochondroprogenitors-effect-of-growth-factors-on-osteogenic-differentiation
#7
Yahya Açil, Björn Möller, Jörg Wiltfang, Fred Fändrich, Hendrik Ungefroren
We have demonstrated previously that peripheral blood monocytes can be converted in vitro to a multipotent stem cell-like cell termed programmable cell of monocytic origin (PCMO) and subsequently into cells with chondrocyte-like phenotype. Here, we investigated whether PCMO could also be differentiated into osteoblast-like cells using growth factors with known osteoinductive potency. Following stimulation with BMP-2, BMP-7, IGF-1 or TGF-β1 for 7 and 14 days, PCMOs were analyzed for mRNA expression of collagen types I and V, alkaline phosphatase, osteocalcin, runt-related transcription factor-2 (Runx2) and Osterix (Osx) by quantitative RT-PCR (qPCR) and the levels of collagen I in culture supernatants by ELISA...
June 4, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28688362/ph-dependent-silver-nanoparticles-releasing-titanium-implant-a-novel-therapeutic-approach-to-control-peri-implant-infection
#8
Yiwen Dong, Hui Ye, Yi Liu, Lihua Xu, Zuosu Wu, Xiaohui Hu, Jianfeng Ma, Janak L Pathak, Jinsong Liu, Gang Wu
Peri-implant infection control is crucial for implant fixation and durability. Antimicrobial administration approaches to control peri-implant infection are far from satisfactory. During bacterial infection, pH level around the peri-implant surface decreases as low as pH 5.5. This change of pH can be used as a switch to control antimicrobial drug release from the implant surface. Silver nanoparticles (AgNPs) have broad-spectrum antimicrobial properties. In this study, we aimed to design a pH-dependent AgNPs releasing titania nanotube arrays (TNT) implant for peri-implant infection control...
June 23, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28683667/early-immunomodulatory-effects-of-implanted-human-perivascular-stromal-cells-during-bone-formation
#9
Carolyn A Meyers, Jiajia Xu, Lei Zhang, Greg Asatrian, Catherine Ding, Noah Yan, Kristen Broderick, Justin Sacks, Raghav Goyal, Xinli Zhang, Kang Ting, Bruno Péault, Chia Soo, Aaron W James
Human perivascular stem/stromal cells (PSC) are a multipotent mesodermal progenitor cell population defined by their perivascular residence. PSC are most commonly derived from subcutaneous adipose tissue, and recent studies have demonstrated the high potential for clinical translation of this fluorescence activated cell sorting (FACS) derived cell population for bone tissue engineering. Specifically, purified PSC induce greater bone formation than unpurified stroma taken from the same patient sample. Here, we examined the differences in early innate immune response to human PSC or unpurified stroma (stromal vascular fraction, SVF) during the in vivo process of bone formation...
July 6, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28682898/heterotopic-ossification-related-to-the-use-of-recombinant-human-bmp-2-in-osteonecrosis-of-femoral-head
#10
Lijun Shi, Wei Sun, Fuqiang Gao, Liming Cheng, Zirong Li
Despite the wide use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in bone defect, its application in treating osteonecrosis of femoral head (ONFH) is yet to be elucidated. The heterotopic ossification (HO) after rhBMP-2 usage in some orthopedic surgeries has been reported previously; however, only a few studies describe this complication in the treatment of ONFH.The present study investigated whether the rhBMP-2 application would increase the risk of HO formation in selected ONFH patients with nonvascularized bone grafting surgery and enhance the surgical results of nonvascularized bone grafting as compared to patients who did not receive intraoperative rhBMP-2...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28665112/nacre-topography-produces-higher-crystallinity-in-bone-than-chemically-induced-osteogenesis
#11
Enateri V Alakpa, Karl E V Burgess, Peter Chung, Mathis O Riehle, Nikolaj Gadegaard, Matthew John Dalby, Maggie Cusack
It is counter-intuitive that invertebrate shells can induce bone formation yet nacre, or mother of pearl, from marine shells is both osteoinductive and osteointegrative. Nacre is composed of aragonite (calcium carbonate) and induces production of vertebrate bone (calcium phosphate). Exploited by the Mayans for dental implants, this remarkable phenomenon has been confirmed in vitro and in vivo yet the characteristic of nacre that induces bone formation remains unknown. By isolating nacre topography from its inherent chemistry in the production of polycaprolactone (PCL) nacre replica, we show that, for mesenchymal stem cells, nacre topography is osteoinductive...
June 30, 2017: ACS Nano
https://www.readbyqxmd.com/read/28659417/human-adipose-stem-cells-induced-to-osteogenic-differentiation-by-an-innovative-collagen-hydroxylapatite-hybrid-scaffold
#12
Elisa Mazzoni, Antonio D'Agostino, Marco Manfrini, Stefania Maniero, Andrea Puozzo, Elena Bassi, Stefano Marsico, Cinzia Fortini, Lorenzo Trevisiol, Simone Patergnani, Mauro Tognon
Novel biomaterials are of paramount importance for bone regrowth. In this study, we investigated human adipose stem cells (hASCs) for osteogenic, osteoconductivity, and osteoinductivity effects of an innovative collagen/hydroxylapatite hybrid scaffold. In hASCs that were grown on this scaffold, osteogenic genes were analyzed for their expression profiles, together with adhesion and extracellular matrix genes. In hASC integrins, basement membrane constituents and collagens were up-regulated, together with cell proliferation...
June 28, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28653337/hardystonite-coated-poly-l-lactide-nanofibrous-scaffold-and-efficient-osteogenic-differentiation-of-adipose-derived-mesenchymal-stem-cells
#13
Banafsheh Tavangar, Shaghayegh Arasteh, Haleh Edalatkhah, Ali Salimi, Ali Doostmohammadi, Ehsan Seyedjafari
In this study, a ceramic-coated nanofibrous scaffold has been fabricated to biomimic the microstructure of natural extracellular matrix and the stiffening inorganic compartment of bone. Poly-l-lactic acid (PLLA) nanofibers were electrospun and exposed to oxygen plasma to induce hydrophilicity and promote ceramic adsorption. Hardystonite (HS), which possesses superior osteoinduction potential over hydroxyapatite, was coated on plasma-treated PLLA nanofibers by drenching the nanofibers in HS suspension. Pure and composite PLLA-based scaffolds were characterized in terms of physical and biological properties...
June 27, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28649897/platelet-concentrates-for-bone-regeneration-current-evidence-and-future-challenges
#14
Zahi Badran, Mohamed-Nur Abdallah, Jesus Torres, Faleh Tamimi
Activated platelet concentrates are autologous blood preparations containing supraphysiological concentration of platelets. Platelet concentrates are commonly used for bone regeneration purposes based on the fact that growth factors released from activated platelets alpha granules have osteoinductive effects on bone cells. Although most preclinical and clinical studies show that platelet concentrates improve the outcomes of bone regeneration procedures, some studies reported conflicting results and even negative effects on bone healing...
June 26, 2017: Platelets
https://www.readbyqxmd.com/read/28647733/role-of-mesenchymal-stem-cells-in-bone-regenerative-medicine-what-is-the-evidence
#15
Ahmad Oryan, Amir Kamali, Ali Moshiri, Mohamadreza Baghaban Eslaminejad
Healing and regeneration of bone injuries, particularly those that are associated with large bone defects, are a complicated process. There is growing interest in the application of osteoinductive and osteogenic growth factors and mesenchymal stem cells (MSCs) in order to significantly improve bone repair and regeneration. MSCs are multipotent stromal stem cells that can be harvested from many different sources and differentiated into a variety of cell types, such as preosteogenic chondroblasts and osteoblasts...
June 24, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/28645809/enhanced-in-vivo-retention-of-low-dose-bmp-2-via-heparin-microparticle-delivery-does-not-accelerate-bone-healing-in-a-critically-sized-femoral-defect
#16
Marian H Hettiaratchi, Tel Rouse, Catherine Chou, Laxminarayanan Krishnan, Hazel Y Stevens, Mon-Tzu A Li, Todd C McDevitt, Robert E Guldberg
Bone morphogenetic protein-2 (BMP-2) is an osteoinductive growth factor used clinically to induce bone regeneration and fusion. Some complications associated with BMP-2 treatment have been attributed to rapid release of BMP-2 from conventional collagen scaffolds, motivating the development of tunable sustained-release strategies. We incorporated BMP-2-binding heparin microparticles (HMPs) into a hydrogel scaffold to improve spatiotemporal control of BMP-2 delivery to large bone defects. HMPs pre-loaded with BMP-2 were mixed into alginate hydrogels and compared to hydrogels containing BMP-2 alone...
June 20, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28645044/mussel-inspired-nano-multilayered-coating-on-magnesium-alloys-for-enhanced-corrosion-resistance-and-antibacterial-property
#17
Bi Wang, Liang Zhao, Weiwei Zhu, Liming Fang, Fuzeng Ren
Magnesium alloys are promising candidates for load-bearing orthopedic implants due to their biodegradability and mechanical resemblance to natural bone tissue. However, the high degradation rate and the risk of implant-associated infections pose grand challenges for their clinical applications. Herein, we developed a nano-multilayered coating strategy through polydopamine and chitosan assisted layer-by-layer assembly of osteoinductive carbonated apatite and antibacterial sliver nanoparticles on the surface of AZ31 magnesium alloys...
June 17, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28644543/osteogenic-potential-of-three-different-autogenous-bone-particles-harvested-during-implant-surgery
#18
Chao Liang, Xiao Lin, Song-Ling Wang, Li-Hua Guo, Xiao-Yu Wang, Jun Li
OBJECTIVES: The aim was to compare the osteoblast activity and osteogenic potential of autogenous bone particles harvested using three different techniques, determine the most advantageous method of collecting autogenous bone particles. SUBJECTS AND METHODS: Bone particles were harvested from 20 patients during dental implant surgery using bone scraping, low-speed drilling, and bone trap filtering. After the osteoblasts were cultured, cell proliferation, migration, mineralization, transcription of osteogenesis-related genes, secretion of osteogenesis-related proteins, and osteoinductive protein content in the bone particle matrix were evaluated...
June 23, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28643418/protein-engineering-of-recombinant-human-bone-morphogenetic-protein-2-with-higher-interaction-with-ca-phosphate-based-scaffold-usedfor-osteogenesis
#19
Mohammad Bayat, Sahar Shojaei, Naghmeh Bahrami, Abdol Reza Mohamadnia, Pegah Shojaei, Naeim Bahrami
The aim of the present studywas to assess the recombinant bonemorphogenetic protein 2 (RHBMP-2)with higher substantively and solubility for use in calcium phosphate scaffolds for better release in differentiation of mesenchymal stem cells to osteoblast cells. By using bioinformatics tools,2 mutations (p. L10D and p. S12E) werechosen and applied in BMP2 CDS sequenceto increase interaction with calcium derived composite. The new recombinant mutated sequence (BMP2(mut) ) was synthesized and then subcloned to expression vector pBV220...
June 23, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28629069/evaluation-of-electrospun-biomimetic-substrate-surface-decorated-with-nanohydroxyapatite-precipitation-for-osteoblasts-behavior
#20
Sai Zhang, Guojun Jiang, Molamma P Prabhakaran, Xiaohong Qin, Seeram Ramakrishna
To engineer bone tissue, it is crucial to design scaffolds with micro- and nano-sized architecture imitating approximate hierarchical structure of native bone, and afford desirable biological properties by introducing biocompatible polymers and bioceramics into the scaffolds. Here, a novel scaffold consisting of poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV)/polyaspartic acid (PAA) was fabricated by electrospinning and nano-hydroxyapatite (nHA) was deposited by calcium-phosphate dipping process for bone tissue regeneration...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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