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Osteoinduction

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https://www.readbyqxmd.com/read/28334693/fabrication-of-human-hair-keratin-jellyfish-collagen-eggshell-derived-hydroxyapatite-osteoinductive-biocomposite-scaffolds-for-bone-tissue-engineering-from-waste-to-regenerative-medicine-products
#1
Yavuz Emre Arslan, Tugba Sezgin Arslan, Burak Derkus, Emel Emregul, Kaan C Emregul
In the present study, we aimed at fabricating an osteoinductive biocomposite scaffold using keratin obtained from human hair, jellyfish collagen and eggshell-derived nano-sized spherical hydroxyapatite (nHA) for bone tissue engineering applications. Keratin, collagen and nHA were characterized with the modified Lowry method, free-sulfhydryl groups and hydroxyproline content analysis, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR) and thermal gravimetric analysis (TGA) which confirmed the success of the extraction and/or isolation processes...
March 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28332482/development-of-novel-silk-fibroin-polyvinyl-alcohol-sol-gel-bioactive-glass-composite-matrix-by-modified-layer-by-layer-electrospinning-method-for-bone-tissue-construct-generation
#2
B N Singh, K Pramanik
The worldwide occurrence of bone tissue related defects as well as diseases and lack of successful perpetual cure has attracted attention and accelerated exploration of composite scaffolding material with superior bioactivity, osteoinductivity and osteoconductivity properties. Among such biomaterials, silk fibroin and bioglass composite attained special emphasis to develop tissue engineered construct with a hierarchical structure ranging from nano to microscale thereby mimicking bone tissue extracellular matrix...
March 23, 2017: Biofabrication
https://www.readbyqxmd.com/read/28326400/staged-total-hip-arthroplasty-in-a-patient-with-hip-dysplasia-and-a-large-pertrochanteric-bone-cyst
#3
Joseph R Langston, Alexander M DeHaan, Thomas W Huff
Hip arthroplasty in young patients requires thoughtful preoperative planning. Patients with proximal femoral bone loss complicate this planning and may require a staged procedure to optimize implant insertion. We report on a case of a 26-year-old woman with secondary hip arthritis from developmental dysplasia of the hip and a large pertrochanteric bone cyst that was treated with staged total hip arthroplasty. The cyst was decompressed and filled with an osteoconductive and osteoinductive bone graft substitute called EquivaBone...
June 2016: Arthroplasty Today
https://www.readbyqxmd.com/read/28325318/preparation-and-characterization-of-amine-functional-nano-hydroxyapatite-chitosan-bionanocomposite-for-bone-tissue-engineering-applications
#4
Besir Hakan Atak, Berna Buyuk, Merve Huysal, Sevim Isik, Mehmet Senel, Wolfgang Metzger, Guven Cetin
In this study, three different types of scaffolds including a uniquely modified composite scaffold - namely chitosan (CTS), nano-hydroxyapatite/chitosan composite (CTS+nHAP), and amine group (NH2) modified nano-hydroxyapatite/chitosan composite (CTS+nHAP-NH2) scaffolds - were synthesized for bone tissue engineering (BTE) purposes. As results of the study, it was found that all scaffold types were biodegradable with CTS and CTS+nHAP scaffolds losing up to 15% of their initial weight, while the CTS+nHAP-NH2 scaffold showing 10% of weight loss after six weeks of lysozyme treatment...
May 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28324211/comparison-of-in-vitro-osteogenic-potential-of-iliac-crest-and-degenerative-facet-joint-bone-autografts-for-intervertebral-fusion-in-lumbar-spinal-stenosis
#5
Jeroen Geurts, Daniela Ramp, Stefan Schären, Cordula Netzer
PURPOSE: The promotion of spinal fusion using bone autografts is largely mediated by the osteoinductive potential of progenitors/mesenchymal stem cells (MSC) that reside in the marrow spaces of cancellous bone. Iliac crest is the common autograft donor site, but its use presents an increased risk for donor site pain, morbidity and infection. Degenerative bone samples harvested during facetectomy might provide an alternative viable source of osteoinductive autografts. In this study, we conducted an intra-individual comparison of the osteogenic potential of isolated low passage MSC from both sources...
March 21, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28314478/osteoinductive-effects-of-glyceollins-on-adult-mesenchymal-stromal-stem-cells-from-adipose-tissue-and-bone-marrow
#6
Marjorie E Bateman, Amy L Strong, Ryan S Hunter, Melyssa R Bratton, Rajesh Komati, Jayalakshmi Sridhar, Kevin E Riley, Guangdi Wang, Daniel J Hayes, Stephen M Boue, Matthew E Burow, Bruce A Bunnell
BACKGROUND: While current therapies for osteoporosis focus on reducing bone resorption, the development of therapies to regenerate bone may also be beneficial. Promising anabolic therapy candidates include phytoestrogens, such as daidzein, which effectively induce osteogenesis of adipose-derived stromal cells (ASCs) and bone marrow stromal cells (BMSCs). PURPOSE: To investigate the effects of glyceollins, structural derivatives of daidzein, on osteogenesis of ASCs and BMSCs...
April 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28299448/capacity-of-muscle-derived-stem-cells-and-pericytes-to-promote-tendon-graft-integration-and-ligamentization-following-anterior-cruciate-ligament-reconstruction
#7
Tomislav Ćuti, Maja Antunović, Inga Marijanović, Alan Ivković, Andreja Vukasović, Igor Matić, Marko Pećina, Damir Hudetz
PURPOSE: The aim of this study is to examine the capacity of muscle tissue preserved on hamstring tendons forming candy-stripe grafts in order to improve tendon to bone ingrowth and ligamentization. We hypothesized that muscle tissue does possess a stem cell population that could enhance the healing process of the ACL graft when preserved on the tendons. METHODS: Human samples from gracilis and semitendinosus muscles were collected during ACL surgery from ten patients and from these tissue samples human muscle-derived stem cells and tendon-derived stem cells were isolated and propagated...
March 15, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28291900/study-of-mesenchymal-stem-cells-cultured-on-a-poly-lactic-co-glycolic-acid-scaffold-containing-simvastatin-for-bone-healing
#8
Dario Mendes Junior, Juliana A Domingues, Moema A Hausen, Silvia M M Cattani, Aguedo Aragones, Alexandre L R Oliveira, Rodrigo F Inácio, Maria L P Barbo, Eliana A R Duek
BACKGROUND: Tissue engineering is a promising alternative for the development of bone substitutes; for this purpose, three things are necessary: stem cells, a scaffold to allow tissue growth and factors that induce tissue regeneration. METHODS: To congregate such efforts, we used the bioresorbable and biocompatible polymer poly(lactic-co-glycolic acid) (PLGA) as scaffold. For the osteoinductive factor, we used simvastatin (SIM), a drug with a pleiotropic effect on bone growth...
March 8, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/28286524/mesenchymal-stem-cells-for-the-treatment-of-spinal-arthrodesis-from-preclinical-research-to-clinical-scenario
#9
REVIEW
F Salamanna, M Sartori, G Barbanti Brodano, C Griffoni, L Martini, S Boriani, M Fini
The use of spinal fusion procedures has rapidly augmented over the last decades and although autogenous bone graft is the "gold standard" for these procedures, alternatives to its use have been investigated over many years. A number of emerging strategies as well as tissue engineering with mesenchymal stem cells (MSCs) have been planned to enhance spinal fusion rate. This descriptive systematic literature review summarizes the in vivo studies, dealing with the use of MSCs in spinal arthrodesis surgery and the state of the art in clinical applications...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28286388/autogenous-bone-marrow-aspirate-coated-synthetic-hydroxyapatite-for-reconstruction-of-maxillo-mandibular-osseous-defects-a-prospective-study
#10
Raja Sekhar Gali, Sathya Kumar Devireddy, N Mohan Rao, R V Kishore Kumar, Sridhar Reddy Kanubaddy, Mallikarjuna Dasari, K Sowjanya, Rama Mohan Pathapati
PURPOSE: This prospective study was conducted to evaluate the bone regeneration capacity of synthetic hydroxyapatite mixed with autogenous bone marrow aspirate when used as a bone graft substitute in maxillo-mandibular osseous defects. METHODS: This study included nine patients with histopathalogically proven benign osteolytic lesions in maxilla and mandible that were treated with enucleation or marginal resection followed by bone marrow aspirate coated synthetic biphasic hydroxyapatite (hydroxyapatite and beta tricalcium phosphate) graft placement...
March 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28281315/silicates-in-orthopaedics-and-bone-tissue-engineering-materials
#11
REVIEW
Xianfeng Zhou, Nianli Zhang, Steven Mankoci, Nita Sahai
Following the success of silicate-based glasses as bioactive materials, silicates are believed to play important roles in promoting bone formation and have therefore been considered to provide a hydroxyapatite surface layer capable of binding to bone as well as potentially being a pro-osteoinductive factor. Natural silicate minerals and silicate-substituted hydroxyapatites are also being actively investigated as orthopaedic bone and dental biomaterials for application in tissue engineering. However, the mechanisms for the proposed roles of silicate in these materials have not been fully understood and are controversial...
March 9, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28266688/the-bmp2-variant-l51p-restores-the-osteogenic-differentiation-of-human-mesenchymal-stromal-cells-in-the-presence-of-intervertebral-disc-cells
#12
A Tekari, R D May, D A Frauchiger, S C Chan, L M Benneker, B Gantenbein
Spinal fusion is hampered by the presence of remaining intervertebral disc (IVD) tissue and leads to spinal non-union. While the exact mechanism remains unknown, we hypothesise that factors preventing disc ossification, such as antagonists of the bone morphogenetic proteins (BMP), could be responsible for this process. The objective of this study was to investigate spinal non-union using an in vitro human model with a focus on the BMP signalling components and to identify factors contributing to the incomplete and delayed ossification...
February 23, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28260001/icaritin-a-novel-plant-derived-osteoinductive-agent-enhances-the-osteogenic-differentiation-of-human-bone-marrow-and-human-adipose-tissue-derived-mesenchymal-stem-cells
#13
Tao Wu, Tao Shu, Le Kang, Jinhui Wu, Jianzhou Xing, Zhiqin Lu, Shuxiang Chen, Jun Lv
For the treatment of diseases affecting bones using bone regenerative medicine, there is an urgent need to develop safe, inexpensive drugs that can strongly induce bone formation. In the present study, we systematically investigated the effects of icaritin, a metabolic product of icariin, on the osteogenic differentiation of human bone marrow‑derived mesenchymal stem cells (hBMSCs) and human adipose tissue‑derived stem cells (hADSCs) in vitro. After treatment with icaritin at concentrations of 10‑8-10‑5 M, hBMSCs and hADSCs were examined for alkaline phosphatase activity, osteocalcin (OC) secretion, matrix mineralization and expression levels of bone‑related mRNA and proteins...
February 24, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28256809/insulin-like-growth-factor-1-igf-1-enhances-the-osteogenic-activity-of-bone-morphogenetic-protein-6-bmp-6-in-vitro-and-in-vivo-and-together-have-a-stronger-osteogenic-effect-than-when-igf-1-is-combined-with-bmp-2
#14
Gustavo A Rico-Llanos, Jose Becerra, Rick Visser
Bone morphogenetic protein-2 (BMP-2) is widely used in orthopedic surgery and bone tissue engineering because of its strong osteogenic activity. However, BMP-2 treatments have several drawbacks and many groups are actively exploring alternatives. Since BMP-6 has been demonstrated to be more osteoinductive, its use, either alone or together with other growth factors, might be an interesting option. In this work we have compared the osteogenic effect of BMP-2, BMP-6 or insulin-like growth factor-1 (IGF-1), either alone or in combination...
March 3, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28254319/evaluation-of-bioactive-glass-incorporated-poly-caprolactone-poly-vinyl-alcohol-matrix-and-the-effect-of-bmp-2-modification
#15
Khamsone Keothongkham, Narattaphol Charoenphandhu, Jirawan Thongbunchoo, Panan Suntornsaratoon, Nateetip Krishnamra, I-Ming Tang, Weeraphat Pon-On
Composite materials having mechanical and biological properties similar to those of human bones are needed for bone regeneration and repair. In the present study, composites were made by incorporating bioactive glass (BG) into polycaprolactone (PCL)-polyvinyl alcohol (PVA) (PCLPVA) matrix. Composites with different BG contents of 10, 25 and 50wt% were fabricated by an in-situ blending method. Physicochemical properties measurements found that the composite with 50wt% BG in the PCLPVA organic matrix exhibited the best mechanical properties (compressive strength and compressive young's modulus up to 32...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28254298/2-n-6-o-sulfated-chitosan-assisted-bmp-2-immobilization-of-pcl-scaffolds-for-enhanced-osteoinduction
#16
Lingyan Cao, Yuanman Yu, Jing Wang, Jerome A Werkmeister, Keith M McLean, Changsheng Liu
The aim of this study was to develop a 2-N, 6-O-sulfated chitosan (26SCS) modified electrospun fibrous PCL scaffold for bone morphogenetic protein-2 (BMP-2) delivery to improve osteoinduction. The PCL scaffold was modified by an aminolysis reaction using ethylenediamine (ED) and 26SCS was immobilized via electrostatic interactions (PCL-N-S). Scaffolds were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS) and contact angle measurements...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28250771/the-influence-of-electrolytic-concentration-on-the-electrochemical-deposition-of-calcium-phosphate-coating-on-a-direct-laser-metal-forming-surface
#17
Qianyue Sun, Yuhui Yang, Wenjing Luo, Jinghui Zhao, Yanmin Zhou
A calcium phosphate (CaP) coating on titanium surface enhances its biocompatibility, thus facilitating osteoconduction and osteoinduction with the inorganic phase of the human bone. Electrochemical deposition has been suggested as an effective means of fabricating CaP coatings on porous surface. The purpose of this study was to develop CaP coatings on a direct laser metal forming implant using electrochemical deposition and to investigate the effect of electrolytic concentration on the coating's morphology and structure by X-ray diffraction, scanning electron microscopy, water contact angle analysis, and Fourier transform infrared spectroscopy...
2017: International Journal of Analytical Chemistry
https://www.readbyqxmd.com/read/28244328/facile-preparation-of-poly-lactic-acid-brushite-bilayer-coating-on-biodegradable-magnesium-alloys-with-multiple-functionalities-for-orthopedic-application
#18
Lei Zhang, Jia Pei, Haodong Wang, Yongjuan Shi, Jialin Niu, Feng Yuan, Hua Huang, Hua Zhang, Guangyin Yuan
Recently magnesium and its alloys have been proposed as a promising next generation orthopedic implant material, whereas the poor corrosion behavior, potential cytotoxicity, and the lack of efficient drug delivery system have limited its further clinical application, especially for the local treatment of infections or musculoskeletal disorders and diseases. In this study, we designed and developed a multifunctional bilayer composite coating of poly(lactic acid)/brushite with high interfacial bonding strength on a Mg-Nd-Zn-Zr alloy, aiming to improve the biocorrosion resistance and biocompatibility of the magnesium-based substrate, as well as to further incorporate the biofunctionality of localized drug delivery...
March 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28240417/engineering-photocrosslinkable-bicomponent-hydrogel-constructs-for-creating-3d-vascularized-bone
#19
Mehdi Kazemzadeh-Narbat, Jeroen Rouwkema, Nasim Annabi, Hao Cheng, Masoumeh Ghaderi, Byung-Hyun Cha, Mansi Aparnathi, Akbar Khalilpour, Batzaya Byambaa, Esmaiel Jabbari, Ali Tamayol, Ali Khademhosseini
Engineering bone tissue requires the generation of a highly organized vasculature. Cellular behavior is affected by the respective niche. Directing cellular behavior and differentiation for creating mineralized regions surrounded by vasculature can be achieved by controlling the pattern of osteogenic and angiogenic niches. This manuscript reports on engineering vascularized bone tissues by incorporating osteogenic and angiogenic cell-laden niches in a photocrosslinkable hydrogel construct. Two-step photolithography process is used to control the stiffness of the hydrogel and distribution of cells in the patterned hydrogel...
February 27, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28230059/synergistic-effects-of-dimethyloxallyl-glycine-and-recombinant-human-bone-morphogenetic-protein-2-on-repair-of-critical-sized-bone-defects-in-rats
#20
Xin Qi, Yang Liu, Zhen-Yu Ding, Jia-Qing Cao, Jing-Huan Huang, Jie-Yuan Zhang, Wei-Tao Jia, Jing Wang, Chang-Sheng Liu, Xiao-Lin Li
In bone remodeling, osteogenesis is closely coupled to angiogenesis. Bone tissue engineering using multifunctional bioactive materials is a promising technique which has the ability to simultaneously stimulate osteogenesis and angiogenesis for repair of bone defects. We developed mesoporous bioactive glass (MBG)-doped poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) composite scaffolds as delivery vehicle. Two bioactive molecules, dimethyloxalylglycine (DMOG), a small-molecule angiogenic drug, and recombinant human bone morphogenetic protein-2 (rhBMP-2), an osteoinductive growth factor, were co-incorporated into the scaffold...
February 23, 2017: Scientific Reports
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