Lauri I Lavikainen, Gordon H Guyatt, Ilkka E J Kalliala, Rufus Cartwright, Anna L Luomaranta, Robin W M Vernooij, Riikka M Tähtinen, Borna Tadayon Najafabadi, Tino Singh, Negar Pourjamal, Sanna M Oksjoki, Nadina Khamani, Päivi K Karjalainen, Kirsi M Joronen, Matthew L Izett-Kay, Jari Haukka, Alex L E Halme, Fang Zhou Ge, Päivi J Galambosi, P J Devereaux, Jovita L Cárdenas, Rachel J Couban, Karoliina M Aro, Riikka L Aaltonen, Kari A O Tikkinen
OBJECTIVE: To provide procedure-specific estimates of the risk of symptomatic venous thromboembolism (VTE) and major bleeding in gynecologic non-cancer surgeries. DATA SOURCES: We conducted comprehensive searches on Embase, MEDLINE, Web of Science, and Google Scholar. Furthermore, we performed separate searches for randomized trials addressing the effects of thromboprophylaxis. STUDY ELIGIBILITY CRITERIA: Observational studies enrolling ≥50 adult patients undergoing gynecologic non-cancer surgery procedures reporting absolute incidence for at least one of the following: symptomatic pulmonary embolism (PE), symptomatic deep vein thrombosis (DVT), symptomatic VTE, bleeding requiring reintervention (including re-exploration and angioembolization), bleeding leading to transfusion or post-operative hemoglobin <70 g/L...
December 8, 2023: American Journal of Obstetrics and Gynecology