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tuberculous meningitis

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https://www.readbyqxmd.com/read/29777209/tuberculous-meningitis-a-roadmap-for-advancing-basic-and-translational-research
#1
Sanjay K Jain, David M Tobin, Elizabeth W Tucker, Vishwanath Venketaraman, Alvaro A Ordonez, Lakshmi Jayashankar, Omar K Siddiqi, Dima A Hammoud, Nemani V Prasadarao, Matyas Sandor, Richard Hafner, Zsuzsanna Fabry
No abstract text is available yet for this article.
May 18, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29758242/diagnostic-accuracy-of-nucleic-acid-amplification-based-assays-for-tuberculous-meningitis-a-meta-analysis
#2
Renu Gupta, Puneet Talwar, Pumanshi Talwar, Sarbjeet Khurana, Suman Kushwaha, Nupur Jalan, Rajeev Thakur
BACKGROUND: Numerous in-house and commercial nucleic acid amplification tests (NAAT) have been evaluated using variable reference standards for diagnosis of TBM but their diagnostic potential is still not very clear. METHODS: We conducted a meta-analysis to assess the diagnostic accuracy of different NAAT based assays for diagnosing TBM against 43 data sets of confirmed TBM (n=1066) and 61 data sets of suspected TBM (n=3721) as two reference standards. The summary estimate of the sensitivity and the specificity were obtained using the bivariate model...
May 11, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29705393/diagnostic-scoring-system-for-tuberculous-meningitis-among-adult-patients-with-non-suppurative-and-non-bacterial-meningitis
#3
Sarunyou Chusri, Thanaporn Hortiwakul, Natthaka Sathaporn, Boonsri Charernmak, Manthana Phengmak, Walailuk Jitpiboon, Alan Frederick Geater
Tuberculous meningitis (TBM) is the most severe form of extra-pulmonary tuberculosis. The definite diagnosis of this disease is difficult and can result in delayed treatment. Conventional culture yields low sensitivity while high-sensitivity diagnostic techniques are costly and unpractical. Adenosine deaminase (ADA) is used to diagnose several settings of extra-pulmonary tuberculosis but it is limited in TBM especially among HIV-infected patients. We retrospectively reviewed the data of patients with non-suppurative meningitis and compared the patient data with TBM and other causes including carcinomatous, lymphomatous, lymphocytic and fungal meningitis...
April 25, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29665948/preclinical-tools-for-the-evaluation-of-tuberculosis-treatment-regimens-for-children
#4
E W Tucker, K E Dooley
Tuberculosis (TB) treatment regimens have been extrapolated from adults to children. However, pediatric disease merits different treatment strategies to avoid under- or over-treatment. While animal models have been pivotal in identifying effective regimens for adult disease, pediatric TB is heterogeneous and cannot be represented by a single preclinical model. Infants and young children most commonly have disseminated disease or tuberculous meningitis (TBM), school-aged children have paucibacillary disease, and adolescents have adult-like cavitary lung disease...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29660820/human-immunodeficiency-virus-in-patients-with-tuberculous-meningitis-systematic-review-and-meta-analysis
#5
REVIEW
Ali Pormohammad, Mohammad Javad Nasiri, Seyed Mohammad Riahi, Fatemeh Fallah
INTRODUCTION: Human immunodeficiency virus (HIV) -infected individuals are at increased risk for all forms of extrapulmonary tuberculosis (TB), including tuberculous meningitis (TBM). The current study aimed to investigate the frequency of HIV in TBM patients. METHODS: PubMed, Embase and Cochrane Library were searched for articles including relevant data. Stata version 14.0 (StataCorp, College Station, Texas, USA) was used to analyze the data. RESULTS: Twenty studies were identified...
April 16, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29652742/use-of-linezolid-in-a-child-with-tuberculous-meningitis
#6
Maria Vittoria De Vita, Erika Silvestro, Carlotta Canavese, Valentina Pennacchietti, Carlo Scolfaro
No abstract text is available yet for this article.
May 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29622715/chiari-malformation-and-tuberculous-meningitis-aetiology-and-management
#7
Jose Danilo Bengzon Diestro, Jesi Ellen Cueto Bautista, Abdelsimar T Omar Ii, James Garcia Mercado, Philip Asuncion Ramiro
This is the first reported case of a Chiari 1 malformation in association with tuberculous (TB) meningitis. We present a case of a 23-year-old woman with a 2-week history nocturnal fever, vertigo, headache and projectile vomiting. She had nystagmus, scanning speech, bilateral papilloedema and ataxia. Cranial imaging showed a 10 mm tonsillar herniation. Posterior fossa decompression was done. Because the patient's gamut of symptoms was highly suspicious for a central nervous system infection, a lumbar tap was done which revealed TB meningitis...
April 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29617975/neuromarker-levels-also-predict-mortality-in-adult-tuberculous-meningitis
#8
Arjan van Laarhoven, Valerie A C M Koeken, Sofiati Dian, Ahmad Rizal Ganiem, Reinout van Crevel
No abstract text is available yet for this article.
March 30, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29604973/other-central-nervous-system-infections-cytomegalovirus-mycobacterium-tuberculosis-and-treponema-pallidum
#9
Christina M Marra
Human immunodeficiency virus (HIV)-infected individuals are particularly susceptible to several central nervous system infections: human cytomegalovirus, which may cause encephalitis, ventriculitis, polyradiculitis, or polyradiculomyelitis; Mycobacterium tuberculosis, which can cause meningitis or space-occupying lesions; and Treponema pallidum subspecies pallidum (T. pallidum), which affects the meninges, cerebrospinal fluid, cranial nerves, and vasculature in early neurosyphilis, and additionally the brain and spinal cord parenchyma in late neurosyphilis...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29579432/clinical-features-vary-by-the-aetiology-of-meningitis-in-hiv-seropositive-patients-a-four-year-study-from-a-tertiary-hospital-in-india
#10
Amalakanti Sridhar, Gajula Krishna Sagar
Meningitis is a serious infection of the nervous system associated with high mortality in Human Immunodeficiency Virus (HIV) seropositive individuals. Asian clinical studies describing meningitis in people living with HIV are scarce. We describe the clinical features of meningitis in 116 HIV seropositive patients from a tertiary hospital in India as a cross-sectional observational study. The mean age of the patients in our study was 35±9 years with 70.6% of them being men. Eighty-five percent of the patients had an altered sensorium during the illness...
April 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29562995/a-study-of-atrial-and-brain-natriuretic-peptides-in-tuberculous-meningitis-and-acute-encephalitis
#11
U K Misra, J Kalita, M Kumar, A Tripathi
OBJECTIVE: To report atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) levels in patients with tuberculous meningitis (TBM) and acute encephalitis syndrome (AES), and evaluate their relationship with hyponatraemia. METHODS: Consecutive patients with TBM and AES were included in the study. Hyponatraemia was categorised as cerebral salt wasting (CSW), syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and a miscellaneous group based on clinical and laboratory criteria...
April 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29560861/can-aspirin-help
#12
Ashwini Kalantri, Shriprakash Kalantri
Using a combination of aspirin, anti-tuberculosis drugs and steroids may help to reduce the number of strokes and deaths in patients with tuberculous meningitis.
March 21, 2018: ELife
https://www.readbyqxmd.com/read/29559684/comparative-whole-genome-sequence-analysis-of-mycobacterium-tuberculosis-isolated-from-tuberculous-meningitis-and-pulmonary-tuberculosis-patients
#13
Kiatichai Faksri, Eryu Xia, Rick Twee-Hee Ong, Jun Hao Tan, Ditthawat Nonghanphithak, Nampueng Makhao, Nongnard Thamnongdee, Arirat Thanormchat, Arisa Phurattanakornkul, Somcharn Rattanarangsee, Chate Ratanajaraya, Prapat Suriyaphol, Therdsak Prammananan, Yik-Ying Teo, Angkana Chaiprasert
Tuberculous meningitis (TBM) is a severe form of tuberculosis with a high mortality rate. The factors associated with TBM pathogenesis are still unclear. Using comparative whole-genome sequence analysis we compared Mycobacterium tuberculosis (Mtb) isolates from cerebrospinal fluid of TBM cases (n = 73) with those from sputum of pulmonary tuberculosis (PulTB) patients (n = 220) from Thailand. The aim of this study was to seek genetic variants of Mtb associated with TBM. Regardless of Mtb lineage, we found 242 variants that were common to all TBM isolates...
March 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29536453/progress-on-diagnosis-of-tuberculous-meningitis
#14
Yi-Yi Wang, Bing-di Xie
Central nervous system (CNS) disease caused by Mycobacterium tuberculosis (MTB) is highly devastating. Tuberculous meningitis (TBM) is the most common form of CNS tuberculosis (TB). Rapid, sensitive, and affordable diagnostic tests are not available. Ziehl-Neelsen (ZN) stain has a very low sensitivity in cases of TBM, the sensitivity rates is of about 10-20%.The detection rate can be improved by taking large volume CSF samples (>6 ml) and prolonged slide examination (30 min). Culture of MTB from the CSF is slow and insufficiently sensitive...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29512478/pediatric-acute-severe-neurologic-illness-and-injury-in-an-urban-and-a-rural-hospital-in-the-democratic-republic-of-the-congo
#15
Taty Tshimangani, Jean Pongo, Joseph Bodi Mabiala, Marcel Yotebieng, Nicole F O'Brien
Empirical knowledge suggests that acute neurologic disorders are common in sub-Saharan Africa, but studies examining the true burden of these diseases in children are scarce. We performed this prospective, observational study to evaluate the prevalence, clinical characteristics, treatment approaches, and outcomes of children suffering acute neurologic illness or injury (ANI) in an urban and rural site in the Democratic Republic of the Congo. Over 12 months, 471 out of 6,563 children admitted met diagnostic criteria for ANI, giving a hospital-based prevalence of 72/1,000 admissions...
May 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29492737/treatment-of-tuberculous-meningitis-and-its-complications-in-adults
#16
REVIEW
Angharad Davis, Graeme Meintjes, Robert J Wilkinson
PURPOSE OF REVIEW: Tuberculous meningitis (TBM) is a global health problem. In this review, we systematically evaluate the evidence for current and emerging antimicrobials, host-directed therapies and supportive managements. RECENT FINDINGS: Current antimicrobial regimes do not factor the differing ability of drugs to cross the blood-brain barrier. Rifampicin may be more effective at higher doses yet the most recent clinical trial failed to demonstrate survival benefit at 15 mg/kg/day...
February 28, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29482717/a-randomised-double-blind-placebo-controlled-phase-2-trial-of-adjunctive-aspirin-for-tuberculous-meningitis-in-hiv-uninfected-adults
#17
Nguyen Th Mai, Nicholas Dobbs, Nguyen Hoan Phu, Romain A Colas, Le Tp Thao, Nguyen Tt Thuong, Ho Dt Nghia, Nguyen Hh Hanh, Nguyen T Hang, A Dorothee Heemskerk, Jeremy N Day, Lucy Ly, Do DA Thu, Laura Merson, Evelyne Kestelyn, Marcel Wolbers, Ronald Geskus, David Summers, Nguyen Vv Chau, Jesmond Dalli, Guy E Thwaites
Adjunctive dexamethasone reduces mortality from tuberculous meningitis (TBM) but not disability, which is associated with brain infarction. We hypothesised that aspirin prevents TBM-related brain infarction through its anti-thrombotic, anti-inflammatory, and pro-resolution properties. We conducted a randomised controlled trial in HIV-uninfected adults with TBM of daily aspirin 81 mg or 1000 mg, or placebo, added to the first 60 days of anti-tuberculosis drugs and dexamethasone (NCT02237365). The primary safety endpoint was gastro-intestinal or cerebral bleeding by 60 days; the primary efficacy endpoint was new brain infarction confirmed by magnetic resonance imaging or death by 60 days...
February 27, 2018: ELife
https://www.readbyqxmd.com/read/29468622/diagnosis-of-chronic-leptomeningitis-by-using-meningeal-biopsy-a-case-report-of-tuberculous-meningitis
#18
Li-Kai Huang, Chien-Min Lin, Chi-Jen Chen, Chaur-Jong Hu
No abstract text is available yet for this article.
September 15, 2017: Acta Neurologica Taiwanica
https://www.readbyqxmd.com/read/29456899/facial-weakness-diplopia-and-fever-in-a-31-year-old-an-atypical-case-of-tuberculous-meningitis
#19
Ahmed H Qavi, Tasnim F Imran, Zachariah Hasan, Fariha Ilyas
Tuberculous meningitis (TBM) is an infection of the central nervous system (CNS) meninges that carries high morbidity and mortality. It is important to recognize, as patients may present with atypical symptoms. We describe the case of a 31-year-old man with a history of diabetes who presented with a sub-acute onset of right-sided facial weakness and right gaze difficulty with diplopia. History revealed low-grade fever, right-sided headache, fatigue and moderate weight loss for the past several weeks. The patient did not report neck stiffness, rigidity, fever, chills or cough...
December 7, 2017: Curēus
https://www.readbyqxmd.com/read/29446860/development-of-a-clinical-prediction-rule-for-tuberculous-meningitis-in-adults-in-lima-peru
#20
Lely Solari, Alonso Soto, Patrick Van der Stuyft
OBJECTIVES: Diagnosis of tuberculous meningitis (TM) is a challenge in countries with a high burden of the disease and constrained resources and clinical prediction rules (CPRs) could be of assistance. We aimed at developing a CPR for diagnosis of TM in a Latin American setting with high tuberculosis incidence and a concentrated HIV epidemic. METHODS: We enrolled adult patients with clinical suspicion of TM attending two hospitals in Lima, Peru. We obtained information on potential anamnestic, clinical and laboratory predictive findings that are easy to collect and promptly available...
April 2018: Tropical Medicine & International Health: TM & IH
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