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Acute Myocardia Infarction

H He, Z-H Zhao, F-S Han, X-H Liu, R Wang, Y-J Zeng
We assessed the effects of protein kinase C ɛ (PKCɛ) for improving stem cell therapy for acute myocardial infarction (AMI). Primary mesenchymal stem cells (MSCs) were harvested from rat bone marrow. PKCɛ-overexpressed MSCs and control MSCs were transplanted into infarct border zones in a rat AMI model. MSCs and PKCɛ distribution and expression of principal proteins involved in PKCɛ signaling through the stromal cell-derived factor 1 (SDF-1)/CXC chemokine receptor type 4 (CXCR4) axis and the phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT) pathway were analyzed by immunofluorescence and western blot 1 day after transplantation...
2016: Cell Death & Disease
Luis E León, Sweta Rani, Mauricio Fernandez, Martín Larico, Sebastián D Calligaris
The prevalence of cardiac diabetic diseases has been increased around the world, being the most common cause of death and disability among diabetic patients. In particular, diabetic cardiomyopathy is characterized with a diastolic dysfunction and cardiac remodelling without signs of hypertension and coronary artery diseases. In an early stage, it is an asymptomatic disease; however, clinical studies demonstrate that diabetic myocardia are more vulnerable to injury derived by acute myocardial infarct and are the worst prognosis for rehabilitation...
2016: Journal of Diabetes Research
Marianna Janion, Agnieszka Janion-Sadowska
Pregnancy-associated myocardial infarction is rare but potentially fatal. Clinical course is different from nonpregnant patients. As it is predominantly non-atherosclerotic in origin, optimal treatment is not unequivocally established. Common anterior wall involvement results in developing of heart failure and its complications. There is a high risk of coronary artery dissection during percutaneous interventions. Pharmacological treatment, beneficial for mother, may be harmful for fetus. Long term prognosis is unclear...
2015: Przegla̧d Lekarski
Yu Kakimoto, Shinji Ito, Hitoshi Abiru, Hirokazu Kotani, Munetaka Ozeki, Keiji Tamaki, Tatsuaki Tsuruyama
BACKGROUND: Few proteomic studies have examined human cardiac tissue following acute lethal infarction. Here, we applied a novel proteomic approach to formalin-fixed, paraffin-embedded human tissue and aimed to reveal the molecular changes in the very early phase of acute myocardial infarction. METHODS AND RESULTS: Heart tissue samples were collected from 5 patients who died within 7 hours of myocardial infarction and from 5 age- and sex-matched control cases. Infarcted and control myocardia were histopathologically diagnosed and captured using laser microdissection...
2013: Journal of the American Heart Association
Juliana Canedo Sebben, Eduardo Cambruzzi, Luisa Martins Avena, Cristina do Amaral Gazeta, Carlos Antonio Mascia Gottschall, Alexandre Schaan de Quadros
BACKGROUND: Percutaneous Coronary Intervention (PCI) is the most common strategy for the treatment of Acute ST segment elevation Myocardia Infarction (STEMI), and thromboaspiration has been increasingly utilized for removal of occlusive thrombi. OBJECTIVES: To analyze the influence of histopathological features of coronary thrombi in clinical outcomes of patients with STEMI, and the association of these variables with clinical, angiographic, and laboratory features and medications used in hospitalization...
December 2013: Arquivos Brasileiros de Cardiologia
Yong-chun Cui, Kai Li, Yi Tian, Zhong Tian, Fu-liang Luo, Jia-fei Luo, Yue Tang
OBJECTIVE: To explore a new method of establishing acute myocardial infarction model in diabetic miniature pigs through video-assisted thoracoscopic surgery (VATS). METHODS: Seven normal miniature pigs and 7 diabetic miniature pigs underwent VATS by selectively ligating left anterior descending coronary artery and then were evaluated through serology, imaging and histology. RESULTS: The serum levels of troponin (cTni) and myoglobin (MYO) in both groups significantly increased by over 10 folds of upper normal limit after VATS...
June 25, 2013: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Jui-Yu Hsieh, Hsei-Wei Wang, Shing-Jyh Chang, Ko-Hsun Liao, I-Hui Lee, Wei-Shiang Lin, Chun-Hsien Wu, Wen-Yu Lin, Shu-Meng Cheng
Mesenchymal stem cells (MSCs) are promising tools for the treatment of diseases such as infarcted myocardia and strokes because of their ability to promote endogenous angiogenesis and neurogenesis via a variety of secreted factors. MSCs found in the Wharton's jelly of the human umbilical cord are easily obtained and are capable of transplantation without rejection. We isolated MSCs from Wharton's jelly and bone marrow (WJ-MSCs and BM-MSCs, respectively) and compared their secretomes. It was found that WJ-MSCs expressed more genes, especially secreted factors, involved in angiogenesis and neurogenesis...
2013: PloS One
Yong Kang Tao, Shui Ping Zhao, Pu Lin Yu, Jing Shi, Cheng Dong Gu, Hong Tao Sun, Guo Qiang Zhang
OBJECTIVE: The mechanism through which platelet activating factor (PAF) induces cardiac electrical activity and arrhythmia is not well understood and previous studies have suggested a potential involvement of ion channels in its action. The present study was aimed to clarify the role of PAF in fatal arrhythmias following acute myocardia infarction (AMI) and the underlying mechanism. METHODS: (1) Blood PAF levels were measured among 72 AMI patients at the time of diagnosis with AMI and 48 h later, and their electrocardiogram (ECG) was recorded continuously...
May 2013: Biomedical and Environmental Sciences: BES
Jian Li, Fang-Fang Yin, Ying-Long Hou
The aim of this study was to detect early changes (within 1-4 h) in the brain natriuretic peptide (BNP) levels of rats with acute myocardial infarction (AMI). A total of 35 Wistar rats were established as models of AMI and 30 sham-operated rats were used as the control group. The myocardia of the two groups were observed using a transmission electron microscope (TEM) prior to and following surgery. A double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) was used to detect the serum BNP and cardiac troponin I (cTnI) concentrations before and 1-4 h after surgery...
April 2013: Experimental and Therapeutic Medicine
Hua Meng, Jun Guo, Ji-Yuan Sun, Jian-Ming Pei, Yue-Min Wang, Miao-Zhang Zhu, Chen Huang
Angelica and ChuanXiong are used to cure ischemic heart disease in China. Previous studies found that these two herbs could increase myocardial blood flow, oxygen-supply and keep myocardial oxygen balance, etc. However, the mechanisms of angiogenic effects of these two herbs are not well-known. The purpose of this study was to assess the effects of Angelica and ChuanXiong on vascular endothelial growth factor (VEGF) expression in rat myocardial infarction, on endothelial cell proliferation and quantity of vessels on chick embryo chorioallantoic membrane (CAM)...
2008: American Journal of Chinese Medicine
Said Audi, Michael Poellmann, Xiaoguang Zhu, Zhixin Li, Ming Zhao
OBJECTIVE: It was recently demonstrated that the radiolabeled C2A domain of synaptotagmin I accumulates avidly in the area at risk after ischemia and reperfusion. The objective was to quantitatively characterize the dynamic uptake of radiolabeled C2A in normal and ischemically injured myocardia using a compartmental model. METHODS: To induce acute myocardial infarction, the left descending coronary artery was ligated for 18 min, followed by reperfusion. [99mTc]C2A-GST or its inactivated form, [99mTc]C2A-GST-NHS, was injected intravenously at 2 h after reperfusion...
November 2007: Nuclear Medicine and Biology
Yue-Xia Jia, Jing-Hui Yang, Chun-Shui Pan, Bin Geng, Jing Zhang, Yang Xiao, Jing Zhao, Helen Gerns, Jun Yang, Jaw-Kang Chang, Jin Kun Wen, Chao-Shu Tang, Yong-Fen Qi
Intermedin is a novel member of the calcitonin/calcitonin gene-related peptide (CGRP) family peptide, which has vasodilatory and hypotensive actions identical to those of adrenomedullin and CGRP. Cleavage sites located between 2 basic amino acids at Arg93-Arg94 result in the production of prepro-intermedin95-147, namely intermedin1-53. The bioactive action of intermedin1-53 and its physiological significance are unclear. In this work, we aimed to explore the effects of intermedin1-53 on acute myocardial injury induced by isoproterenol...
November 7, 2006: European Journal of Pharmacology
Steffen Huber, Raja Muthupillai, Brenda Lambert, Mercedes Pereyra, Alicia Napoli, Scott D Flamm
PURPOSE: To determine whether contrast between acutely infarcted and normal myocardia in T1-rho-weighted cine TFE (T1rho-TFE) and delayed-enhancement (DE) images (measured using a metric percent enhancement (PE)) varied with the dose or time of imaging after contrast administration. MATERIALS AND METHODS: Eighteen patients with acute myocardial infarction (AMI) were randomly divided into three groups according to the dose of gadoversetamide (0.1, 0.2, or 0.3 mmol/kg) administered...
November 2006: Journal of Magnetic Resonance Imaging: JMRI
Ming Li, Cheuk Man Yu, Lei Cheng, Mei Wang, Xuemei Gu, Ka Ho Lee, Tian Wang, Yn Tz Sung, John E Sanderson
BACKGROUND: It has become apparent recently that cardiac myocytes can divide after myocardial infarction, a circumstance that challenges the orthodox view that myocytes may be terminally differentiated. Replacement of the necrosed heart tissue by newly regenerated functional myocardium is a therapeutic ideal, but attempts to reconstitute functional myocardia and coronary vessels have been less successful. METHODS: We isolated a fraction containing 5 compounds from the Chinese herb Geum japonicum, which stimulates the processes of angiogenesis and cardiomyogenesis...
August 2006: Clinical Chemistry
Koen Nieman, Ricardo C Cury, Maros Ferencik, Cesar H Nomura, Suhny Abbara, Udo Hoffmann, Herman K Gold, Ik-Kyung Jang, Thomas J Brady
Clinical use of cardiac computed tomography is rapidly expanding, and its purpose may reach beyond noninvasive coronary angiography. We investigated the ability of 64-slice multidetector computed tomography to differentiate between recent and long-standing myocardial infarction (MI). Contrast-enhanced coronary computed tomographic (CT) scans (Siemens Sensation 64) of patients with a recent MI (< 7 days, n = 16), long-standing MI (> 12 months, n = 13), and no MI (n = 13) were retrospectively evaluated...
August 1, 2006: American Journal of Cardiology
Yukitoshi Shirakawa, Yoshiki Sawa, Yoshiaki Takewa, Eisuke Tatsumi, Yasufumi Kaneda, Yoshiyuki Taenaka, Hikaru Matsuda
BACKGROUND: Although a left ventricular assist device is often used to provide circulatory support until transplantation in severe heart failure, the mortality of long-term use of left ventricular assist devices remains high. We have shown that hepatocyte growth factor causes angiogenesis, antifibrosis, and antiapoptosis in the myocardium. Therefore, gene therapy with hepatocyte growth factor-complementary DNA plasmids may enhance the chance of "bridge to recovery." In this study, we performed gene therapy with hepatocyte growth factor in the impaired goat heart with a left ventricular assist device...
September 2005: Journal of Thoracic and Cardiovascular Surgery
No abstract text is available yet for this article.
June 1951: Delaware Medical Journal
Q Liu, Z Lu
To evaluate the effect of Salvia Miltiorrhiza on coronary collateral circulation in dogs with experimental acute myocardial infarction, 12 dogs were randomly divided into Salvia Miltiorrhiza group (group D) and control group (group C). Acute myocardial infarction model was established in all dogs, Salvia Miltiorrhiza or saline was administered to the 2 groups respectively for 21 days. Coronary angiography was performed before and after ligation of coronary artery. The capillaries and distribution vessel density in tissue sections of myocardia were assessed...
1999: Journal of Tongji Medical University, Tong Ji Yi Ke da Xue Xue Bao
M Spindler, B Illing, M Horn, M de Groot, G Ertl, S Neubauer
This review describes the temporal changes of high-energy phosphate metabolites during the cardiac cycle. Under baseline condition, the extent of cyclical changes ("cycling") of ATP, phosphocreatine and inorganic phosphate varies between 10-15%. Such energy oscillations are not augmented under various forms of metabolic stress including 1) inotropic stimulation, 2) acute hypoxia and 3) failing, chronically infarcted hearts. Thus, the concentrations of high-energy phosphates over the cardiac cycle are a tightly regulated entity, even when energetic needs are substantially augmented...
November 2001: Basic Research in Cardiology
J R Swanson, T A Pearson
BACKGROUND: The National Cholesterol Education Program strongly recommends screening family members of patients with early cardiovascular disease (CVD) for coronary risk factors, but the physician and patient compliance with this recommendation has not been extensively studied. The American College of Cardiology Evaluation of Preventive Therapeutics (ACCEPT) study, a national survey conducted in 1996-1997, determined if physicians were screening first-degree relatives of patients with early CVD...
January 2001: American Journal of Preventive Medicine
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