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https://www.readbyqxmd.com/read/27923154/socioeconomic-position-john-henryism-and-incidence-of-acute-myocardial-infarction-in-finnish-men
#1
Mahasin S Mujahid, Sherman A James, George A Kaplan, Jukka T Salonen
Previous cross-sectional studies examining whether John Henryism (JH), or high-effort coping with socioeconomic adversity, potentiates the inverse association between socioeconomic position (SEP) and cardiovascular health have focused mainly on hypertension in African Americans. We conducted the first longitudinal test of this hypothesis on incident acute myocardial infarction (AMI) using data from the Kuopio Ischemic Heart Disease Risk Factor Study in Finland (N = 1405 men, 42-60 years). We hypothesized that the expected inverse gradient between SEP and AMI risk would be stronger for men scoring high on JH than for those scoring low...
November 25, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/27922910/impact-of-medicare-s-nonpayment-program-on-hospital-acquired-conditions
#2
Caroline P Thirukumaran, Laurent G Glance, Helena Temkin-Greener, Meredith B Rosenthal, Yue Li
BACKGROUND: Medicare's Nonpayment Program of 2008 (hereafter called Program) withholds hospital reimbursement for costs related to hospital-acquired conditions (HACs). Little is known whether a hospital's Medicare patient load [quantified by the hospital's Medicare utilization ratio (MUR), which is the proportion of inpatient days financed by Medicare] influences its response to the Program. OBJECTIVE: To determine whether the Program was associated with changes in HAC incidence, and whether this association varies across hospitals with differential Medicare patient load...
December 5, 2016: Medical Care
https://www.readbyqxmd.com/read/27921405/thrombolytic-therapy-up-regulates-inflammatory-mediators-compared-to-percutaneous-coronary-intervention-pci
#3
Alireza Garjani, Bahram Sohrabi, Ali Akbar Movassaghpour, Sina Andalib, Mehriar Shokri, Bahar Taherkhanchi, Bahador Bagheri
The important role of reperfusion therapies in the treatment of acute myocardial infarction is well documented. However, reperfusion therapies can initiate inflammatory response and may damage the myocardium. The purpose of current study was to compare the effects of percutaneous coronary intervention and thrombolytic therapy on inflammatory markers in the setting of ST elevation myocardial infarction (STEMI). Eighty three patients with STEMI were enrolled in this study. 40 patients underwent percutaneous coronary intervention (PCI), and 43 patients received streptokinase (1...
August 2016: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/27920833/the-association-between-defibrillation-shock-energy-and-acute-cardiac-damage-in-patients-with-implantable-cardioverter-defibrillators
#4
Daisuke Ishigaki, Daisuke Kutsuzawa, Takanori Arimoto, Tadateru Iwayama, Naoaki Hashimoto, Yu Kumagai, Satoshi Nishiyama, Hiroki Takahashi, Tetsuro Shishido, Takuya Miyamoto, Joji Nitobe, Akio Fukui, Tetsu Watanabe, Isao Kubota
BACKGROUND: The aim of this study was to establish a minimally invasive defibrillation testing (DT) protocol for patients with implantable cardioverter defibrillators (ICDs). METHODS: Two different energy DTs were performed, immediately after (15 J-DT) and 7 days after (≤10 J-DT) device implantation, in 20 consecutive ICD implantation patients. Cardiac-troponin T (c-TNT) and heart-type fatty acid binding protein (H-FABP) levels were measured before implantation, 2 h after implantation, and 1 day after each DT...
December 2016: Journal of Arrhythmia
https://www.readbyqxmd.com/read/27920547/predictive-value-of-nt-probnp-for-30-day-mortality-in-patients-with-non-st-elevation-acute-coronary-syndromes-a-comparison-with-the-grace-and-timi-risk-scores
#5
Dirk Aam Schellings, Ahmet Adiyaman, Jan-Henk E Dambrink, At Marcel Gosselink, Elvin Kedhi, Vincent Roolvink, Jan Paul Ottervanger, Arnoud Wj Van't Hof
BACKGROUND: The biomarker N-terminal pro-brain natriuretic peptide (NT-proBNP) predicts outcome in patients with non-ST-elevation acute coronary syndromes (NSTE-ACS). Whether NT-proBNP has incremental prognostic value beyond established risk strategies is still questionable. PURPOSE: To evaluate the predictive value of NT-proBNP for 30-day mortality over and beyond the Global Registry of Acute Coronary Events (GRACE) and Thrombolysis In Myocardial Infarction (TIMI) risk scores in patients with NSTE-ACS...
2016: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/27919348/hdl-function-is-impaired-in-acute-myocardial-infarction-independent-of-plasma-hdl-cholesterol-levels
#6
Wijtske Annema, Hendrik M Willemsen, Jan Freark de Boer, Arne Dikkers, Markus van der Giet, Wybe Nieuwland, Anneke C Muller Kobold, L Joost van Pelt, Riemer H J A Slart, Iwan C C van der Horst, Robin P F Dullaart, René A Tio, Uwe J F Tietge
BACKGROUND: High-density lipoproteins (HDLs) protect against the development of atherosclerotic cardiovascular disease. HDL function represents an emerging concept in cardiovascular research. OBJECTIVE: This study investigated the association between HDL functionality and acute myocardial infarction (MI) independent of HDL-cholesterol plasma levels. METHODS: Participants (non-ST-segment elevation MI, non-STEMI, n = 41; STEMI, n = 37; non-MI patients, n = 33) from a prospective follow-up study enrolling patients with acute chest pain were matched for age and plasma HDL cholesterol...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27919293/perioperative-statin-therapy-in-cardiac-surgery-a-meta-analysis-of-randomized-controlled-trials
#7
Alessandro Putzu, Bruno Capelli, Alessandro Belletti, Tiziano Cassina, Enrico Ferrari, Michele Gallo, Gabriele Casso, Giovanni Landoni
BACKGROUND: Several studies suggest beneficial effects of perioperative statin therapy on postoperative outcome after cardiac surgery. However, recent randomized controlled trials (RCTs) show potential detrimental effects. The objective of this systematic review is to examine the association between perioperative statin therapy and clinical outcomes in cardiac surgery patients. METHODS: Electronic databases were searched up to 1 November 2016 for RCTs of preoperative statin therapy versus placebo or no treatment in adult cardiac surgery...
December 5, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27918806/differences-in-electrocardiographic-findings-between-acute-isolated-right-ventricular-myocardial-infarction-and-acute-anterior-myocardial-infarction
#8
Brooks Myrick Walsh, Stephen W Smith
No abstract text is available yet for this article.
December 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27918805/differences-in-electrocardiographic-findings-between-acute-isolated-right-ventricular-myocardial-infarction-and-acute-anterior-myocardial-infarction
#9
Masami Kosuge, Kazuo Kimura
No abstract text is available yet for this article.
December 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27917389/impact-of-chronic-kidney-insufficiency-on-cardiovascular-outcomes-in-patients-that-undergo-coronary-revascularization-a-historical-review
#10
Koh Choong Hou, Kenny Sin Yoong Kong, Terence Kee Yi Shern, Jack Tan Wei Chieh
Chronic kidney disease (CKD) is associated with poorer short and long-term cardiovascular morbidity and mortality. Even after the commencement of haemodialysis in end stage renal failure patients, mortality exceeds 20% in the first year(1). More than 50% of these deaths are contributed by cardiovascular diseases (CVD), of which 20% are caused by acute myocardial infarction(2). Consequent to these findings, the degree and impact of coronary revascularization on CKD patients represents a clinical challenge, especially in the setting of advanced stages of CKD...
November 2016: ASEAN Heart Journal: Official Journal of the ASEAN Federation of Cardiology
https://www.readbyqxmd.com/read/27917140/can-illness-perceptions-predict-lower-heart-rate-variability-following-acute-myocardial-infarction
#11
Mary Princip, Marco Scholz, Rebecca E Meister-Langraf, Jürgen Barth, Ulrich Schnyder, Hansjörg Znoj, Jean-Paul Schmid, Julian F Thayer, Roland von Känel
Objective: Decreased heart rate variability (HRV) has been reported to be a predictor of mortality after myocardial infarction (MI). Patients' beliefs and perceptions concerning their illness may play a role in decreased HRV. This study investigated if illness perceptions predict HRV at 3 months following acute MI. Methods: 130 patients referred to a tertiary cardiology center, were examined within 48 h and 3 months following acute MI. At admission, patients' cognitive representations of their MI were assessed using the German version of the self-rated Brief Illness Perception Questionnaire (Brief IPQ)...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27916154/cancer-history-portends-worse-acute-and-long-term-noncardiac-but-not-cardiac-mortality-after-primary-percutaneous-coronary-intervention-for-acute-st-segment-elevation-myocardial-infarction
#12
Feilong Wang, Rajiv Gulati, Ryan J Lennon, Bradley R Lewis, Jae Park, Gurpreet S Sandhu, R Scott Wright, Amir Lerman, Joerg Herrmann
OBJECTIVE: To define the effect of a history of cancer on in-hospital and long-term mortality after primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). PATIENTS AND METHODS: In this retrospective cohort study of 2346 patients with STEMI enrolled in the Mayo Clinic PCI registry from November 1, 2000, through October 31, 2010, we identified 261 patients (11.1%) with a history of cancer. The in-hospital and long-term outcomes (median follow-up, 6...
December 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27916115/highly-sensitive-and-specific-derivatization-strategy-to-profile-and-quantitate-eicosanoids-by-uplc-ms-ms
#13
Ting Hu, Cai Tie, Zhe Wang, Jin-Lan Zhang
Eicosanoids are signaling molecules mainly oxidized from arachidonic acid (ARA) and eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). They have attracted increasing attention from the scientists attributing to their essential physiological functions. However, their quantification have long been challenged by the low abundance, high structure similarity, poor stability and limited ionization efficiency. In this paper, an ultra-high performance liquid chromatograph coupled with tandem mass spectrometry (UPLC-MS/MS) strategy was developed for the comprehensive profiling of more than 60 eicosanoids based on an efficient derivatization reagent 2,4-bis(diethylamino)-6-hydrazino-1,3,5-triazine (T3) and general multiple reaction monitoring (MRM) parameters...
January 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27916047/-the-impact-of-different-doses-of-atorvastatin-on-plasma-endothelin-and-platelet-function-in-acute-st-segment-elevation-myocardial-infarction-after-emergency-percutaneous-coronary-intervention
#14
X R Xu, K B Li, P Wang, L Xu, Y Liu, Z S Yang, X C Yang
Objective: To investigate the effects of different doses of atorvastatin on plasma endothelin and platelet function in acute ST-segment elevation myocardial infarction (STEMI) patients after emergency percutaneous coronary intervention(PCI). Methods: A total of 120 patients with acute STEMI treated with emergency PCI were enrolled and randomly divided into 20 mg of atorvastatin treatment group (standard group, n=60), and 40 mg of atorvastatin treatment group (intensive group, n=60). The blood C reactive protein (CRP), blood lipid profiles, plasma endothelin (ET) were measured before atorvastatin treatment and after 7 days of treatment, respectively...
December 1, 2016: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/27915331/screening-of-bioactive-ingredients-in-ligusticum-chuanxiong-hort-for-protection-against-myocardial-ischemia
#15
Xu Liu, Xiuzhong Li, Songgang Ji, Xiaobo Cui, Mingchun Li
BACKGROUND/AIMS: To study the spectrum-effect relationship and effective components of Ligusticum Chuanxiong Hort. (LCH) on the protection of canine myocardial ischemia. METHODS: Fingerprint spectrum of LCH extracts was developed using high performance liquid chromatography (HPLC), and a canine model of acute myocardial ischemia was established by ligating the coronary artery. Bivariate correlation analysis and multivariate regression analysis were used to correlate the pharmacodynamics of LCH extract and its common peaks in HPLC...
December 5, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27915162/high-fat-diet-induces-metabolic-changes-and-reduces-oxidative-stress-in-female-mouse-hearts
#16
Ignasi Barba, Elisabet Miró-Casas, José L Torrecilla, Eulàlia Pladevall, Sergi Tejedor, Rubén Sebastián-Pérez, Marisol Ruiz-Meana, José R Berrendero, Antonio Cuevas, David García-Dorado
After an acute myocardial infarction, obese patients generally have a better prognosis than their leaner counterparts, known as the "obesity paradox". In addition, female sex is associated with a lower risk of cardiac ischemic events and smaller infarct size compared to males. The objective of the present work was to study the metabolic phenotype and mitochondrial function associated to female sex and short-term high-fat diet. (1)H NMR spectra of mice heart extracts were analysed by mRMR variable selection and linear discriminant analysis was used to evaluate metabolic changes...
November 15, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27915044/a-novel-aldosterone-synthase-inhibitor-ameliorates-mortality-in-pressure-overload-mice-with-heart-failure
#17
Shinji Furuzono, Masaki Meguro, Satoru Miyauchi, Shinichi Inoue, Tsuyoshi Homma, Keisuke Yamada, Yoh-Ichi Tagawa, Futoshi Nara, Takahiro Nagayama
It has been elucidated that mineralocorticoid receptor antagonists reduce mortality in patients with congestive heart failure and post-acute myocardial infarction. A direct inhibition of aldosterone synthase (CYP11B2) is also expected to have therapeutic benefits equal in quality to mineralocorticoid receptor antagonists in terms of reducing mineralocorticoid receptor signaling. Therefore, we have screened our chemical libraries and identified a novel and potent aldosterone synthase inhibitor, 2,2,2-trifluoro-1-{4-[(4-fluorophenyl)amino]pyrimidin-5-y}-1-[1-(methylsulfonyl)piperidin-4-yl]ethanol (compound 1), by lead optimization...
November 30, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27914667/high-sensitivity-troponin-t-and-the-risk-of-recurrent-readmissions-after-hospitalisation-for-acute-heart-failure
#18
D Escribano, E Santas, G Miñana, A Mollar, S García-Blas, E Valero, A Payá, F J Chorro, J Sanchis, J Núñez
OBJECTIVES: High-sensitivity troponin is a biomarker of myocardial damage and is associated with a greater risk of mortality and disease progression in patients with acute heart failure (AHF). However, its relationship with the risk of future readmissions is less known. The aim of this study was to assess the association between ultrasensitive troponin T (TnT-us) values in patients with AHF and the risk of recurrent readmissions in the follow-up. METHODS: We prospectively included a cohort of 621 consecutive patients with AHF, excluding those patients with acute coronary syndrome...
November 30, 2016: Revista Clínica Española
https://www.readbyqxmd.com/read/27914504/on-treatment-analysis-of-the-improved-reduction-of-outcomes-vytorin-efficacy-international-trial-improve-it
#19
Michael A Blazing, Robert P Giugliano, James A de Lemos, Christopher P Cannon, Andrew Tonkin, Christie M Ballantyne, Basil S Lewis, Thomas A Musliner, Andrew M Tershakovec, Yuliya Lokhnygina, Jennifer A White, Craig Reist, Amy McCagg, Eugene Braunwald
BACKGROUND: We aimed to determine the efficacy and safety of adding ezetimibe (Ez) to simvastatin (S) in a post-acute coronary syndrome (ACS) population in a prespecified on-treatment analysis. METHODS: We evaluated 17,706 post-ACS patients from the IMPROVE-IT trial who had low-density lipoprotein cholesterol values between 50 and 125 mg/dL and who received Ez 10 mg/d with S 40 mg/d (Ez/S) or placebo with simvastatin 40 mg/d (P/S). The primary composite end point was cardiovascular death, myocardial infarction, unstable angina, coronary revascularization ≥30 days postrandomization, or stroke...
December 2016: American Heart Journal
https://www.readbyqxmd.com/read/27914488/safety-of-6-month-duration-of-dual-antiplatelet-therapy-after-percutaneous-coronary-intervention-in-patients-with-acute-coronary-syndromes-rationale-and-design-of-the-smart-angioplasty-research-team-safety-of-6-month-duration-of-dual-antiplatelet-therapy-after
#20
Joo Myung Lee, Deok-Kyu Cho, Joo-Yong Hahn, Young Bin Song, Taek Kyu Park, Ju-Hyeon Oh, Jin Bae Lee, Joon-Hyung Doh, Sang-Hyun Kim, Jeong Hoon Yang, Jin-Ho Choi, Seung-Hyuck Choi, Sang Hoon Lee, Hyeon-Cheol Gwon
BACKGROUND AND RATIONALE: Dual antiplatelet therapy (DAPT) is a fundamental treatment that optimizes clinical outcomes after percutaneous coronary intervention, especially in patients with acute coronary syndrome (ACS). Although current international guidelines recommend DAPT for at least 12 months after implantation of a drug-eluting stent in patients with ACS, these recommendations are not based on randomized controlled trials dedicated to ACS population. STUDY DESIGN: The SMART-DATE trial is a prospective, multicenter, randomized, and open-label study to demonstrate the noninferiority of 6-month DAPT compared with 12 months or longer DAPT in patients with ACS undergoing percutaneous coronary intervention...
December 2016: American Heart Journal
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