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https://www.readbyqxmd.com/read/28993187/inpatient-glucose-values-determining-the-nondiabetic-range-and-use-in-identifying-patients-at-high-risk-for-diabetes
#1
Mary K Rhee, Sandra E Safo, Sandra L Jackson, Wenqiong Xue, Darin E Olson, Qi Long, Diana Barb, J Sonya Haw, Anne M Tomolo, Lawrence S Phillips
BACKGROUND: Many individuals with diabetes remain undiagnosed, leading to delays in treatment and higher risk for subsequent diabetes complications. Despite recommendations for diabetes screening in high risk groups, the optimal approach is not known. We evaluated the utility of inpatient glucose levels as an opportunistic screening tool for identifying patients at high risk for diabetes. METHODS: We retrospectively examined 462,421 patients in the national VA healthcare system, hospitalized on medical/surgical services in 2000-2010, for ≥3 days, with ≥2 inpatient random plasma glucose (RPG) measurements...
October 6, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28985413/the-challenges-in-the-estimation-of-the-effective-dose-when-wearing-radioprotective-garments
#2
C Saldarriaga Vargas, L Struelens, F Vanhavere
The performance of a single or double dosimetry (SD or DD) algorithm on estimating effective dose wearing radioprotective garments (ERPG) depends on the specific irradiation conditions. This study investigates the photon energies and angles of incidence for which the estimation of ERPG with the personal dose equivalents measured over and under the RPG (Ho and Hu) becomes more challenging. The energy and angular dependences of ERPG, Ho and Hu were Monte Carlo calculated for photon exposures. The personal dosimeter of SCK · CEN was modeled and used to determine Ho and Hu...
June 16, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28888458/the-high-content-of-%C3%AE-carotene-present-in-orange-pulp-fruits-of-carica-papaya-l-is-not-correlated-with-a-high-expression-of-the-cplcy-%C3%AE-2-gene
#3
Arianna C Chan-León, Humberto Estrella-Maldonado, Pascal Dubé, Gabriela Fuentes Ortiz, Francisco Espadas-Gil, Carlos Talavera May, Jorge Ramírez Prado, Yves Desjardins, Jorge M Santamaría
We investigated the transcriptional regulation of six genes involved in carotenoid biosynthesis, together with the carotenoid accumulation during postharvest ripening of three different papaya genotypes of contrasting pulp color. Red-pulp genotype (RPG) showed the lowest content of yellow pigments (YP), such as β-cryptoxanthin, zeaxanthin, and violaxanthin, together with the lowest relative expression levels (REL) of CpLCY-β2 and CpCHX-β genes. On the contrary, the yellow-pulp genotype (YPG) showed the highest content of YP and the highest REL of CpLCY-β2 and CpCHX-β genes...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28813631/rapid-and-targeted-introgression-of-fgr-gene-through-marker-assisted-backcrossing-in-rice-oryza-sativa-l
#4
Acga Cheng, Ismanizan Ismail, Mohamad Osman, Habibuddin Hashim, Nur Samahah Mohd Zainual
While it is crucial for developing countries like Malaysia to achieve self-sufficiency in rice (Oryza sativa L.), it is equally critical to be able to produce high-quality rice, specifically fragrant rice, which demands are often met through importation. The present study was aimed at developing high-yielding fragrant rice, in a timely and cost-effective manner. A marker-assisted backcross (MABC) approach was optimised to introgress the fragrance gene (fgr) into two high-yielding Malaysian varieties; MR84 and MR219, within two years utilising less than fifty molecular markers...
August 16, 2017: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28797628/refuse-derived-fuel-rdf-production-and-gasification-in-a-pilot-plant-integrated-with-an-otto-cycle-ice-through-aspen-plus%C3%A2-modelling-thermodynamic-and-economic-viability
#5
Albany Milena Lozano Násner, Electo Eduardo Silva Lora, José Carlos Escobar Palacio, Mateus Henrique Rocha, Julian Camilo Restrepo, Osvaldo José Venturini, Albert Ratner
This work deals with the development of a Refuse Derived Fuel (RDF) gasification pilot plant using air as a gasification agent. A downdraft fixed bed reactor is integrated with an Otto cycle Internal Combustion Engine (ICE). Modelling was carried out using the Aspen Plus™ software to predict the ideal operational conditions for maximum efficiency. Thermodynamics package used in the simulation comprised the Non-Random Two-Liquid (NRTL) model and the Hayden-O'Connell (HOC) equation of state. As expected, the results indicated that the Equivalence Ratio (ER) has a direct influence over the gasification temperature and the composition of the Raw Produced Gas (RPG), and effects of ER over the Lower Heating Value (LHV) and Cold Gasification Efficiency (CGE) of the RPG are also discussed...
August 7, 2017: Waste Management
https://www.readbyqxmd.com/read/28739803/chromatin-remodeling-swi-snf-complex-regulates-coenzyme-q6-synthesis-and-a-metabolic-shift-to-respiration-in-yeast
#6
Agape M Awad, Srivats Venkataramanan, Anish Nag, Anoop Raj Galivanche, Michelle C Bradley, Lauren T Neves, Stephen Douglass, Catherine F Clarke, Tracy L Johnson
Despite its relatively streamlined genome, there are many important examples of regulated RNA splicing in Saccharomyces cerevisiae Here, we report a role for the chromatin remodeler SWI/SNF in respiration, partially via the regulation of splicing. We find that a nutrient-dependent decrease in Snf2 leads to an increase in splicing of the PTC7 transcript. The spliced PTC7 transcript encodes a mitochondrial phosphatase regulator of biosynthesis of coenzyme Q6 (ubiquinone or CoQ6) and a mitochondrial redox-active lipid essential for electron and proton transport in respiration...
September 8, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28717973/design-and-development-of-repaglinide-microemulsion-gel-for-transdermal-delivery
#7
Ujwala A Shinde, Sheela H Modani, Kavita H Singh
Microemulsion formulation of repaglinide, a BCS class II hypoglycemic agent with limited oral bioavailability, was developed considering its solubility in various oils, surfactants, and cosurfactants. The pseudo-ternary phase diagrams for microemulsion regions were constructed by water titration method at K m 1:1 and characterized for optical birefringence, percentage transmittance, pH, refractive index, globule size, zeta potential, viscosity, drug content, and thermodynamic stability. To enhance the drug permeation and residence time, the optimized microemulsions having mean globule size of 36...
July 17, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28678925/gestational-protein-restriction-increases-cardiac-connexin-43-mrna-levels-in-male-adult-rat-offspring
#8
Kamila Fernanda Rossini, Camila Andrea de Oliveira, Hércules Jonas Rebelato, Marcelo Augusto Marreto Esquisatto, Rosana Catisti
Background: The dietary limitation during pregnancy influences the growth and development of the fetus and offspring and their health into adult life. The mechanisms underlying the adverse effects of gestational protein restriction (GPR) in the development of the offspring hearts are not well understood. Objectives: The aim of this study was to evaluate the effects of GPR on cardiac structure in male rat offspring at day 60 after birth (d60). Methods: Pregnant Wistar rats were fed a normal-protein (NP, 17% casein) or low-protein (LP, 6% casein) diet...
July 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28660457/marker-assisted-breeding-for-introgression-of-opaque-2-allele-into-elite-maize-inbred-line-bml-7
#9
M S R Krishna, S Sokka Reddy, Sadam D V Satyanarayana
Improvement of quality protein maize (QPM) along with high content of lysine and tryptophan had foremost importance in maize breeding program. The efficient and easiest way of developing QPM hybrids was by backcross breeding in marker aided selection. Hence, the present investigation aimed at conversion of elite maize inbred line BML-7 into QPM line. CML-186 was identified to be a donor variety as it revealed high-quality polymorphism with BML-7 for opaque-2 gene specific marker umc1066. Non-QPM inbred line BML-7 was crossed with QPM donor CML-186 and produced F1 followed by the development of BC1F1 and BC2F1 population...
July 2017: 3 Biotech
https://www.readbyqxmd.com/read/28479356/quantitative-analysis-of-complex-drug-drug-interactions-between-repaglinide-and-cyclosporin-a-gemfibrozil-using-physiologically-based-pharmacokinetic-models-with-in%C3%A2-vitro-transporter-enzyme-inhibition-data
#10
Soo-Jin Kim, Kota Toshimoto, Yoshiaki Yao, Takashi Yoshikado, Yuichi Sugiyama
Quantitative analysis of transporter- and enzyme-mediated complex drug-drug interactions (DDIs) is challenging. Repaglinide (RPG) is transported into the liver by OATP1B1 and then is metabolized by CYP2C8 and CYP3A4. The purpose of this study was to describe the complex DDIs of RPG quantitatively based on unified physiologically based pharmacokinetic (PBPK) models using in vitro Ki values for OATP1B1, CYP3A4, and CYP2C8. Cyclosporin A (CsA) or gemfibrozil (GEM) increased the blood concentrations of RPG. The time profiles of RPG and the inhibitors were analyzed by PBPK models, considering the inhibition of OATP1B1 and CYP3A4 by CsA or OATP1B1 inhibition by GEM and its glucuronide and the mechanism-based inhibition of CYP2C8 by GEM glucuronide...
May 4, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28338880/the-yield-and-feasibility-of-integrated-screening-for-tb-diabetes-and-hiv-in-four-public-hospitals-in-ethiopia
#11
Degu Jerene, Nebiyu Hiruy, Ilili Jemal, Wondimu Gebrekiros, Tadesse Anteneh, Dereje Habte, Muluken Melese, Pedro Suarez, Gloria Sangiwa
Background: Our objective was to demonstrate the feasibility of integrated care for TB, HIV and diabetes mellitus (DM) in a pilot project in Ethiopia. Methods: Healthcare workers in four hospitals screened patients with TB for HIV and DM; patients with HIV for DM and TB; and patients with DM for TB. Fasting and random plasma glucose (RPG) tests were used to confirm the diagnosis of DM. We used screening checklists for TB and DM, and additional risk scoring criteria to identify patients at risk of DM...
March 1, 2017: International Health
https://www.readbyqxmd.com/read/28276787/granulated-colloidal-silicon-dioxide-based-self-microemulsifying-tablets-as-a-versatile-approach-in-enhancement-of-solubility-and-therapeutic-potential-of-anti-diabetic-agent-formulation-design-and-in-vitro-in-vivo-evaluation
#12
Vikas Pandey, Ritu M Gilhotra, Seema Kohli
The current research work was executed with an aim to explore and promote the potential of self-microemusifying drug delivery systems (SMEDDS) in the form of tablets, in order to enhance solubility and oral bioavailability of poorly aqueous soluble drug Repaglinide (RPG). RPG-loaded liquid SMEDDS were developed consisting Labrafil M 1944CS, Kolliphor EL and Propylene glycol, which were then characterized on various parameters. After characterization and optimization, liquid SMEDDS were converted into solid form by adsorbing on Aeroperl® 300 pharma and polyplasdone(TM) XL...
June 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28264936/deletion-of-ribosomal-protein-genes-is-a-common-vulnerability-in-human-cancer-especially-in-concert-with-tp53-mutations
#13
Ram Ajore, David Raiser, Marie McConkey, Magnus Jöud, Bernd Boidol, Brenton Mar, Gordon Saksena, David M Weinstock, Scott Armstrong, Steven R Ellis, Benjamin L Ebert, Björn Nilsson
Heterozygous inactivating mutations in ribosomal protein genes (RPGs) are associated with hematopoietic and developmental abnormalities, activation of p53, and altered risk of cancer in humans and model organisms. Here we performed a large-scale analysis of cancer genome data to examine the frequency and selective pressure of RPG lesions across human cancers. We found that hemizygous RPG deletions are common, occurring in about 43% of 10,744 cancer specimens and cell lines. Consistent with p53-dependent negative selection, such lesions are underrepresented in TP53-intact tumors (P ≪ 10(-10)), and shRNA-mediated knockdown of RPGs activated p53 in TP53-wild-type cells...
April 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28063165/diabetes-plasma-glucose-and-incidence-of-pancreatic-cancer-a-prospective-study-of-0-5-million-chinese-adults-and-a-meta-analysis-of-22-cohort-studies
#14
Yuanjie Pang, Christiana Kartsonaki, Yu Guo, Fiona Bragg, Ling Yang, Zheng Bian, Yiping Chen, Andri Iona, Iona Y Millwood, Jun Lv, Canqing Yu, Junshi Chen, Liming Li, Michael V Holmes, Zhengming Chen
Diabetes is associated with an increased risk of pancreatic cancer (PC) in Western populations. Uncertainty remains, however, about the relevance of plasma glucose for PC among people without diabetes and about the associations of diabetes and high blood glucose with PC in China where the increase in diabetes prevalence has been very recent. The prospective China Kadoorie Biobank (CKB) study recruited 512,000 adults aged 30-79 years from 10 diverse areas of China during 2004-2008, recording 595 PC cases during 8 years of follow-up...
April 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28060464/rna-polymerase-ii-components-and-rrn7-form-a-preinitiation-complex-on-the-homold-box-to-promote-ribosomal-protein-gene-expression-in-schizosaccharomyces-pombe
#15
Matías Montes, Sandra Moreira-Ramos, Diego A Rojas, Fabiola Urbina, Norbert F Käufer, Edio Maldonado
In Schizosaccharomyces pombe, ribosomal protein gene (RPG) promoters contain a TATA box analog, the HomolD box, which is bound by the Rrn7 protein. Despite the importance of ribosome biogenesis for cell survival, the mechanisms underlying RPG transcription remain unknown. In this study, we found that components of the RNA polymerase II (RNAPII) system, consisting of the initiation or general transcription factors (GTFs) TFIIA, IIB, IIE, TATA-binding protein (TBP) and the RNAPII holoenzyme, interacted directly with Rrn7 in vitro, and were able to form a preinitiation complex (PIC) on the HomolD box...
February 2017: FEBS Journal
https://www.readbyqxmd.com/read/27901104/development-and-evaluation-of-near-isogenic-lines-for-brown-planthopper-resistance-in-rice-cv-9311
#16
Cong Xiao, Jie Hu, Yi-Ting Ao, Ming-Xing Cheng, Guan-Jun Gao, Qing-Lu Zhang, Guang-Cun He, Yu-Qing He
Brown planthopper (BPH) is the most destructive pest of rice in Asia. To date 29 BPH resistance genes have been identified, but only a few genes are being used in breeding due to inefficient markers for marker-assisted selection (MAS) and little knowledge of the real effects of the genes. In this study we individually transferred 13 genes or QTLs (Bph14, QBph3, QBph4, Bph17, Bph15, Bph20, Bph24, Bph6, Bph3, Bph9, Bph10, Bph18 and Bph21) into cultivar 9311 by marker assisted backcross breeding (MABB). Through positive and negative selection we narrowed the segments from donors containing Bph14, Bph15, Bph6 and Bph9 to 100-400 kb...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27871205/the-effects-of-two-different-swimming-training-periodization-on-physiological-parameters-at-various-exercise-intensities
#17
Vicente Javier Clemente-Suárez, Athanasios Dalamitros, João Ribeiro, Ana Sousa, Ricardo J Fernandes, J Paulo Vilas-Boas
This study analysed the effects of two different periodization strategies on physiological parameters at various exercise intensities in competitive swimmers. Seventeen athletes of both sexes were divided to two groups, the traditional periodization (TPG, n = 7) and the reverse periodization group (RPG, n = 10). Each group followed a 10-week training period based on the two different periodization strategies. Before and after training, swimming velocity (SV), energy expenditure (EE), energy cost (EC) and percentage of aerobic (%Aer) and anaerobic (%An) energy contribution to the swimming intensities corresponding to the aerobic threshold (AerT), the anaerobic threshold (AnT) and the velocity at maximal oxygen uptake (vVO2max) were measured...
May 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/27862082/influence-of-salt-tolerant-trichoderma-spp-on-growth-of-maize-zea-mays-under-different-salinity-conditions
#18
Krishna Kumar, K Manigundan, Natarajan Amaresan
In the present study, a total of 70 Trichoderma spp. were isolated from the rhizosphere soils of vegetable and spice crops that were grown in Andaman and Nicobar Islands, India. Initial screening of Trichoderma spp. for salt tolerant properties showed 32 isolates were able to tolerate 10% NaCl. Furthermore, these isolates were screened for their potential plant growth-promoting characteristics such as IAA production, phosphate solubilization, and siderophore production. Among 32 isolates, nine isolates were able to produce IAA, siderophore, and solubilize phosphate...
February 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/27818142/a-molecular-titration-system-coordinates-ribosomal-protein-gene-transcription-with-ribosomal-rna-synthesis
#19
Benjamin Albert, Britta Knight, Jason Merwin, Victoria Martin, Diana Ottoz, Yvonne Gloor, Maria Jessica Bruzzone, Adam Rudner, David Shore
Cell growth potential is determined by the rate of ribosome biogenesis, a complex process that requires massive and coordinated transcriptional output. In the yeast Saccharomyces cerevisiae, ribosome biogenesis is highly regulated at the transcriptional level. Although evidence for a system that coordinates ribosomal RNA (rRNA) and ribosomal protein gene (RPG) transcription has been described, the molecular mechanisms remain poorly understood. Here we show that an interaction between the RPG transcriptional activator Ifh1 and the rRNA processing factor Utp22 serves to coordinate RPG transcription with that of rRNA...
November 17, 2016: Molecular Cell
https://www.readbyqxmd.com/read/27778337/marker-assisted-introgression-of-broad-spectrum-blast-resistance-genes-into-the-cultivated-mr219-rice-variety
#20
Gous Miah, Mohd Y Rafii, Mohd R Ismail, Adam B Puteh, Harun A Rahim, Mohammad A Latif
BACKGROUND: The rice cultivar MR219 is famous for its better yield and long and fine grain quality; however, it is susceptible to blast disease. The main objective of this study was to introgress blast resistance genes into MR219 through marker-assisted selection (MAS). The rice cultivar MR219 was used as the recurrent parent, and Pongsu Seribu 1 was used as the donor. RESULTS: Marker-assisted foreground selection was performed using RM6836 and RM8225 to identify plants possessing blast resistance genes...
October 24, 2016: Journal of the Science of Food and Agriculture
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