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https://www.readbyqxmd.com/read/27792215/an-up-todate-on-the-methabolic-syndrome-s-epigenomic-risk
#1
Rosanna Perricone, Antonio Pizzuti
The primitive genome's and the individual phenotype's modifications by epygenesys surveyes are crucial to evaluate the methabolic syndrome risk and its prevention. Through the most recent surveys, this analysis is aimed to several processes by which the various epigenetic types who are different from one to another subject may act on the methabolism key-genes, like that they even indirectly arouse the straight onset of one or more methabolic syndromes: the risk of passing this syndrome to next offsprings is more or less high...
October 28, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27568334/neuroprotective-effect-of-magnesium-acetyltaurate-against-nmda-induced-excitotoxicity-in-rat-retina
#2
Lidawani Lambuk, Azliana Jusnida Ahmad Jafri, Natasha Najwa Nor Arfuzir, Igor Iezhitsa, Renu Agarwal, Khairul Nizam Bin Rozali, Puneet Agarwal, Nor Salmah Bakar, Methil Kannan Kutty, Ahmad Pauzi Md Yusof, Anna Krasilnikova, Alexander Spasov, Alexander Ozerov, Nafeeza Mohd Ismail
Glutamate excitotoxicity plays a major role in the loss of retinal ganglion cells (RGCs) in glaucoma. The toxic effects of glutamate on RGCs are mediated by the overstimulation of N-methyl-D-aspartate (NMDA) receptors. Accordingly, NMDA receptor antagonists have been suggested to inhibit excitotoxicity in RGCs and delay the progression and visual loss in glaucoma patients. The purpose of the present study was to examine the potential neuroprotective effect of Mg acetyltaurate (MgAT) on RGC death induced by NMDA...
August 27, 2016: Neurotoxicity Research
https://www.readbyqxmd.com/read/27331031/nutraceutical-supplement-in-the-management-of-tendinopathies-a-systematic-review
#3
REVIEW
Federico Fusini, Salvatore Bisicchia, Carlo Bottegoni, Antonio Gigante, Fabio Zanchini, Alberto Busilacchi
BACKGROUND: nutraceuticals are common support therapy for management of tendinopathies. Even if they are widely diffused, our knowledge is still poor. The aim of this systematic review is to analyze the most commonly used nutraceuticals and their effects on tendons. METHODS: glucosamine and chondroitin sulphate, vitamin C, hydrolazed type 1 collagen, arginine alpha-keto-glutarate, bromelain, curcumin, boswellic acid, and methil-sulfonil-methane were considered. During the last week of Dicember 2015 a comprehensive research of main databases for each substance was made in relation with tendinopathy...
January 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/27012609/protective-effect-of-magnesium-acetyltaurate-against-endothelin-induced-retinal-and-optic-nerve-injury
#4
N N N Arfuzir, L Lambuk, A J A Jafri, R Agarwal, I Iezhitsa, S Sidek, P Agarwal, N S Bakar, M K Kutty, A P Md Yusof, A Krasilnikova, A Spasov, A Ozerov, N Mohd Ismail
Vascular dysregulation has long been recognized as an important pathophysiological factor underlying the development of glaucomatous neuropathy. Endothelin-1 (ET1) has been shown to be a key player due to its potent vasoconstrictive properties that result in retinal ischemia and oxidative stress leading to retinal ganglion cell (RGC) apoptosis and optic nerve (ON) damage. In this study we investigated the protective effects of magnesium acetyltaurate (MgAT) against retinal cell apoptosis and ON damage. MgAT was administered intravitreally prior to, along with or after administration of ET1...
June 14, 2016: Neuroscience
https://www.readbyqxmd.com/read/26933278/current-trends-of-liposuction-in-india-survey-and-analysis
#5
Bijoy Methil
BACKGROUND: Liposuction is the commonest aesthetic procedure performed by Indian plastic surgeons. However, there exists substantial disparity amongst Indian surgeons about guidelines concerning liposuction. To address this disparity, a nationwide email survey (Association of Plastic Surgeons of India [APSI] database) was started in December 2013 and continued for 5 months. MATERIAL AND METHODS: The survey was developed with software from www.fluidsurveys.com. The study was designed to cover most aspects of patient selection, perioperative management, technical considerations, postoperative management and complications...
September 2015: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/26621556/combinations-of-phytomedicines-with-different-lipid-lowering-activity-for-dyslipidemia-management-the-available-clinical-data
#6
Arrigo F G Cicero, Alessandro Colletti
BACKGROUND: Cardiovascular diseases are the primary cause of death and the leading cause of disability in industrialized countries. Dyslipidemia is a major independent and reversible risk factor for these diseases: it is estimated that a reduction of 1 mmol/l (38 mg/dl) of LDL cholesterol is associated with a risk of developing a cardiovascular complication reduced by 25%, a reduction potentially achieved by life-style improvement associated to adequate dietary supplementation with bioactive substances...
October 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/26424219/topical-trans-resveratrol-ameliorates-steroid-induced-anterior-and-posterior-segment-changes-in-rats
#7
Norhafiza Razali, Renu Agarwal, Puneet Agarwal, Minaketan Tripathy, Marina Y Kapitonova, Methil K Kutty, Alexey Smirnov, Zalizah Khalid, Nafeeza M Ismail
Steroid-induced hypertension and glaucoma is associated with increased extracellular meshwork (ECM) deposition in trabecular meshwork (TM). Previous studies have shown that single drop application of trans-resveratrol lowers IOP in steroid-induced ocular hypertensive (SIOH) rats. This IOP lowering is attributed to activation of adenosine A1 receptors, which may lead to increased matrix metalloproteinase (MMP)-2 activity. This study evaluated the effect of repeated topical application of trans-resveratrol for 21 days in SIOH animals on IOP, changes in MMP-2 level in aqueous humor, trabecular meshwork and retinal morphology and retinal redox status...
February 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/25740651/detection-of-sarcocystosis-in-goats-in-malaysia-by-light-microscopy-histology-and-pcr
#8
Methil Kannan Kutty, Baha Latif, Azdayanti Muslim, Jamal Hussaini, Aqil Mohammad Daher, Chong Chin Heo, Sulaiman Abdullah
A number of methods have been used for the detection of the presence of microsarcocysts in animals, but little information exists on the value between the various methods. This study therefore examined for Sarcocystis spp. using three different methods in 105 samples of skeletal muscle collected from goats slaughtered in an abattoir in Selangor, Malaysia from January to February 2014. Three methods were used, direct light microscopy of squashed fresh muscle tissues; histological examination of fixed, sectioned, and hematoxylin and eosin (H&E)-stained samples of muscle; and molecular identification by polymerase chain reaction (PCR)...
April 2015: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/25481859/anterior-and-posterior-segment-changes-in-rat-eyes-with-chronic-steroid-administration-and-their-responsiveness-to-antiglaucoma-drugs
#9
Norhafiza Razali, Renu Agarwal, Puneet Agarwal, Marina Y Kapitonova, Methil Kannan Kutty, Alexey Smirnov, Nor Salmah Bakar, Nafeeza M Ismail
Steroid-induced ocular hypertension (SIOH) is associated with topical and systemic use of steroids. However, SIOH-associated anterior and posterior segment morphological changes in rats have not been described widely. Here we describe the pattern of intraocular pressure (IOP) changes, quantitative assessment of trabecular meshwork (TM) and retinal morphological changes and changes in retinal redox status in response to chronic dexamethasone treatment in rats. We also evaluated the responsiveness of steroid-pretreated rat eyes to 5 different classes of antiglaucoma drugs that act by different mechanisms...
February 15, 2015: European Journal of Pharmacology
https://www.readbyqxmd.com/read/23872256/evaluation-of-the-anti-inflammatory-activity-of-riparin-ii-o-methil-n-2-hidroxi-benzoyl-tyramine-in-animal-models
#10
Alyne Mara Rodrigues de Carvalho, Nayrton Flávio Moura Rocha, Leonardo Freire Vasconcelos, Emiliano Ricardo Vasconcelos Rios, Marília Leite Dias, Maria Izabel Gomes Silva, Marta Maria de França Fonteles, José Maria Barbosa Filho, Stanley Juan Chavez Gutierrez, Francisca Cléa Florenço de Sousa
Riparin II (RipII), an alkamide isolated from the green fruit of Aniba riparia, was tested in the various animal models of inflammation to investigate its anti-inflammatory activity. Male Wistar rats (180-240g) were treated with RipII by gavage at doses 25 or 50mg/kg, before initiating the inflammatory responses. The tests used were paw edema induced by carrageenan, dextran, histamine or serotonin; peritonitis induced by carrageenan and fMLP, as well as the measurement of MPO activity, TNF-α and Il-1β amount in the peritoneal fluid...
October 5, 2013: Chemico-biological Interactions
https://www.readbyqxmd.com/read/22994106/-the-influence-of-water-soluble-antioxidant-agent-mexidol-on-optic-nerve-and-blood-flow-velocity-in-ocular-and-orbital-arteries-in-patients-with-primary-open-angle-glaucoma
#11
RANDOMIZED CONTROLLED TRIAL
I A Volchegorskiĭ, E V Tur, O V Soliannikova, V S Rykun, E V Berdnikova, M S Sumina, V N Dmitrienko
The prospective single-blind placebo-controlled randomized trial is devoted to influence of mexidol (2-ethil-6-methil-3-hydroxipiridine succinate) on dynamics of optic nerve electrophysiologic profile and velocity indices of blood flow in ocular and orbital arteries in correlation with changes of retinal photosensitivity, visual acuity and visual field size during course of intravenous mexidol infusions and standard treatment of primary open-angle glaucoma. 2 weeks of intravenous infusions of 300 mg mexidol daily was found to cause depression of optic nerve electrical sensitivity threshold and widening of total visual field (16 mm2 test stimulus) after 14 days of treatment...
July 2012: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/22771633/review-of-stem-cell-deregulation-and-breast-cancer-an-emerging-hypothesis
#12
REVIEW
Darnal Hari Kumar, Methil Kannan Kutty
Cancer is fundamentally a cellular genetic disease capable of transferring the "disease" to the next generation of mutated cells. Similar proliferative and information transferring capacity exists in the stem cells of various organ systems in the human body. Understanding the bio-mechanism of stem cell metabolism and its regulation by signaling molecules and extracellular micro-environment is an important step toward successful prevention and treatment of cancer. According to the cancer stem cell hypothesis, both hereditary and sporadic cancers can arise from deregulation of these cancer stem cells (CSCs), triggered by genetic and environmental factors...
April 2012: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/21526401/palm-tocotrienols-decrease-levels-of-pro-angiogenic-markers-in-human-umbilical-vein-endothelial-cells-huvec-and-murine-mammary-cancer-cells
#13
Kanga Rani Selvaduray, Ammu K Radhakrishnan, Methil Kannan Kutty, Kalanithi Nesaretnam
Anti-angiogenic therapy is widely being used to halt tumour angiogenesis. In this study, the anti-angiogenic activity of palm tocotrienol-rich fraction (TRF) and its individual components (γ- and δ-tocotrienol) were first investigated in vitro in human umbilical vein endothelial cells (HUVEC) and 4T1 mouse mammary cancer cells. Results showed reduced levels of Interkeukin (IL)-8 and IL-6, two pro-angiogenic cytokines in HUVEC treated with palm tocotrienols compared with α-tocopherol (α-T) and control cells (P < 0...
January 2012: Genes & Nutrition
https://www.readbyqxmd.com/read/21495889/human-accidents-involving-rhinocricus-spp-a-common-millipede-genus-observed-in-urban-areas-of-brazil
#14
Eduardo Mello De Capitani, Ronan José Vieira, Fábio Bucaretchi, Luciane C R Fernandes, Adriana Safioti Toledo, Adriana C Camargo
OBJECTIVE: The most important millipede species causing accidents in Brazil is Rhinocricus padbergi (order Spirobolida, family Rhinocricidae), a vegetarian scavenger distributed from Central to South America. Eleven clinical cases of dermal and oral accidental exposures to secretions from Rhinocricus spp. milipedes are described. CASE SERIES: Eleven cases of skin and oral involvement after accidental contact with the secretions of Rhinocricus spp. in patients from 1to 46 years are detailed...
March 2011: Clinical Toxicology
https://www.readbyqxmd.com/read/21121862/palm-tocotrienols-inhibit-proliferation-of-murine-mammary-cancer-cells-and-induce-expression-of-interleukin-24-mrna
#15
Kanga Rani Selvaduray, Ammu K Radhakrishnan, Methil Kannan Kutty, Kalanithi Nesaretnam
Several mechanisms have been postulated for the anticancer effects of tocotrienols. In this study, for the first time, the anticancer effect of tocotrienols is linked to increased expression of interleukin-24 (IL-24) mRNA, a cytokine reported to have antitumor effects in many cancer models. Tocotrienol isomers (α-T3, γ-T3, and δ-T3) and tocotrienol-rich fraction (TRF) inhibited the growth of the 4T1 murine mammary cancer cells (P < 0.05), with IC₅₀ values 8.99, 4.79, 3.73, and 8.63 μg/mL, respectively...
December 2010: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/20734801/-infringement-of-the-seasonal-rhythm-of-fluctuations-of-the-oxidized-and-methylated-guanine-s-contents-in-urine-of-mice-after-the-irradiation
#16
A S Solov'eva, L K Obukhova, A A Konradov
The lifetime research of the oxidized and methilated guanine's contents in urine of intact and radiated mice was carried out. For statistical processing of results we used the method of the trial periods. This method has been created by A.A. Konradov, but has not been published during a life of the author. It has allowed finding out oscillatory part of age-related dependences. For intact animals the most probable (p = 0.001) is the period of 7 months. The infringement of a seasonal rhythm of fluctuations of oxidized and methilated guanine's concentration in urine is marked for the radiated mice...
May 2010: Radiatsionnaia Biologiia, Radioecologiia
https://www.readbyqxmd.com/read/16256857/liens-entre-r%C3%A3-sistance-et-%C3%A3-chec-dans-les-infections-respiratoires-communautaires
#17
J-P Bru, P Léophonte, C Carbon
Resistance is one of failure's reasons. We tried, through clinical experience, to approach the magnitude and nature of the links, between phenotypically defined acquired resistance and clinical failure, in community acquired respiratory infections. An efficient resistance mecanism, able to suppress antibiotic action, is clearely associated to a risk of clinical failure (e.g. betalactamase secretion, target modification using methilation for macrolides, target mutation for fluoroquinoles). Resistance mecanism due to reduction of target affinity (pneumococcus and betalactams) progressively decreasing beta lactam activity depending on its expression, is at present time, not clearely associeted with clinical failure...
August 2005: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/16245386/-link-between-resistance-and-failure-in-community-acquired-respiratory-infections
#18
REVIEW
J P Bru, P Léophonte, C Carbon
Resistance is one of failure's reasons. We tried, through clinical experience, to approach the magnitude and nature of the links, between phenotypically defined acquired resistance and clinical failure, in community acquired respiratory infections. An efficient resistance mecanism, able to suppress antibiotic action, is clearely associated to a risk of clinical failure (e.g. betalactamase secretion, target modification using methilation for macrolides, target mutation for fluoroquinoles). Resistance mecanism due to reduction of target affinity (pneumococcus and betalactams) progressively decreasing beta lactam activity depending on its expression, is at present time, not clearely associeted with clinical failure...
August 2005: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/15935531/does-the-absence-of-the-palmaris-longus-affect-grip-and-pinch-strength
#19
S J Sebastin, A Y T Lim, W H Bee, T C M Wong, B V Methil
The palmaris longus tendon is the most frequently harvested tendon for reconstructive plastic and hand surgical procedures. A question patients often ask is whether loss of the palmaris longus will result in any functional deficit. In order to answer this question, the presence or absence of the palmaris longus muscle was clinically determined in 418 normal Asian subjects. All subjects also had their grip and pinch strengths measured. No statistically significant difference was seen in the grip or pinch strength measurements between subjects who had a palmaris longus tendon and those who did not...
August 2005: Journal of Hand Surgery: Journal of the British Society for Surgery of the Hand
https://www.readbyqxmd.com/read/14608269/-diagnosis-and-differential-diagnosis-of-obesity-in-childhood
#20
REVIEW
A Crinò, N A Greggio, L Beccaria, R Schiaffini, A Pietrobelli, C Maffeis
About 2-3% of "essential" obesity in pediatric age is of endocrine or genetic origin (secondary obesity). The clinical picture of these forms is almost always characteristic; however, some patients affected by secondary obesity can present with an incomplete or atypical aspect. The aim of this review is to offer the pediatrician useful indications to correctly diagnose children presenting with obesity. It is advisable to make a careful anamnesis and an accurate medical examination in order to ascertain the causes that may have contributed to the onset and increase of weight gain...
October 2003: Minerva Pediatrica
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