Tirppur C R Ramakrishnan, Somasundaram Kumaravelu, Sunil K Narayan, Sai S Buddha, Ch Murali, Palakkapparampil H A Majeed, Salvadeeswaran Meenakshi-Sundaram, Rustom S Wadia, Vikram Sharma, Indraneel Basu, Pamidimukkala Vijaya, Kizhakkaniyakath A Salam, Shahid Barmare, Zubin Vaid, K K Nirmal Raj, Pandurang R Wattamwar, Konbappan Asokan, Vijaykumar Dhonge, Shankara Nellikunja, Deepak Namjoshi, Rangasetty Srinivasa, Deepak S Laddhad, Shirish D Deshpande, Balakrishnan Raghunath, Jayantee Kalita, Mritunjai Kumar, Usha K Misra, Methil Pradeep
BACKGROUND: Tenecteplase (TNK-tPA) is a promising third-generation plasminogen activator, because of its greater fibrin specificity and longer half-life than alteplase. There is a paucity of studies on intravenous thrombolysis using TNK-tPA in developing countries. The present study has been undertaken to compare the efficacy and safety of TNK-tPA with alteplase. METHODS: Two studies were conducted. Study I was an open-label, randomized study in which two doses of TNK-tPA (0...
October 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions