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Maria cristina paganini

Rachele Ciccocioppo, Alessandra Gallia, Maria A Avanzini, Elena Betti, Cristina Picone, Alessandro Vanoli, Chiara Paganini, Federico Biagi, Rita Maccario, Gino R Corazza
Type II refractory celiac disease (RCD), as defined according to the amount of aberrant intraepithelial lymphocytes, is a condition characterized by severe malabsorption syndrome and poor prognosis, with no effective treatment. Based on the regenerative and immunomodulatory properties of mesenchymal stem cells (MSCs), we investigated the feasibility, safety, and efficacy of serial infusions of autologous bone marrow-derived MSCs in a 51-year-old woman with type II RCD. Mesenchymal stem cells were isolated, expanded, and characterized following standard protocols...
June 2016: Mayo Clinic Proceedings
Michelle Freire Baliza, Regina Szylit Bousso, Kátia Poles, Maiara Rodrigues Dos Santos, Lucía Silva, Maria Cristina Paganini
OBJECTIVE: To identify the factors that influence the Intensive Care Unit nurse in the decision-making process in end-of-life situations. METHOD: Ethnographic case study, which used the theoretical framework of medical anthropology. Data were collected through semi-structured interviews with 10 nurses. RESULTS: The inductive thematic analysis enabled us to identify four themes:The cultural context of the Intensive Care Unit: decision-making in situations of end-of-life; Beliefs and subjectivity of care in end-of-life situations; Professional experience and context characteristics of end-of-life care situations; and Humanization practices in end-of-life situations: the patient and family centered care...
August 2015: Revista da Escola de Enfermagem da U S P
Ann Gallagher, Regina Szylit Bousso, Joan McCarthy, Helen Kohlen, Tom Andrews, Maria Cristina Paganini, Nasser Ibrahim Abu-El-Noor, Anna Cox, Margit Haas, Anne Arber, Mysoon Khalil Abu-El-Noor, Michelle Freire Baliza, Katia Grillo Padilha
BACKGROUND: Intensive care units (ICUs) focus on treatment for those who are critically ill and interventions to prolong life. Ethical issues arise when decisions have to be made regarding the withdrawal and withholding of life-sustaining treatment and the shift to comfort and palliative care. These issues are particularly challenging for nurses when there are varying degrees of uncertainty regarding prognosis. Little is known about nurses' end-of-life (EoL) decision-making practice across cultures...
April 2015: International Journal of Nursing Studies
José Ramón González-Porras, María Eva Mingot-Castellano, Marcio M Andrade, Rafael Alonso, Isabel Caparrós, María Carmen Arratibel, Fernando Fernández-Fuertes, Maria José Cortti, Cristina Pascual, Blanca Sánchez-González, Silvia Bernat, Miguel Angel Fuertes-Palacio, Juan Andrés Vázquez-Paganini, Pavel E Olivera, María Teresa Alvarez-Román, Isidro Jarque, Montserrat Cortés, Violeta Martínez-Robles, Francisco Javier Díaz-Gálvez, María Calbacho, Carmen Fernández-Miñano, Javier Garcia-Frade, Tomás José González-López
The thrombopoietin receptor agonists (THPO-RAs), romiplostim and eltrombopag, are effective and safe in immune thrombocytopenia (ITP). However, the value of their sequential use when no response is achieved or when adverse events occur with one THPO-RA has not been clearly established. Here we retrospectively evaluated 51 primary ITP adult patients treated with romiplostim followed by eltrombopag. The median age of our cohort was 49 (range, 18-83) years. There were 32 women and 19 men. The median duration of romiplostim use before switching to eltrombopag was 12 (interquartile range 5-21) months...
April 2015: British Journal of Haematology
Tomás José González-López, Cristina Pascual, María Teresa Álvarez-Román, Fernando Fernández-Fuertes, Blanca Sánchez-González, Isabel Caparrós, Isidro Jarque, María Eva Mingot-Castellano, José Angel Hernández-Rivas, Mónica Martín-Salces, Laura Solán, Paola Beneit, Reyes Jiménez, Silvia Bernat, Marcio M Andrade, Montserrat Cortés, Maria José Cortti, Susana Pérez-Crespo, Marta Gómez-Núñez, Pavel E Olivera, Gloria Pérez-Rus, Violeta Martínez-Robles, Rafael Alonso, Angeles Fernández-Rodríguez, María Carmen Arratibel, María Perera, Carmen Fernández-Miñano, Miguel Angel Fuertes-Palacio, Juan Andrés Vázquez-Paganini, Isabel Gutierrez-Jomarrón, Inés Valcarce, Erik de Cabo, Adriana Sainz, Rosa Fisac, Carlos Aguilar, María Paz Martínez-Badas, María Jesús Peñarrubia, María Calbacho, Carmen de Cos, Manuel González-Silva, Erika Coria, Arancha Alonso, Alberto Casaus, Armando Luaña, Pilar Galán, Cristina Fernández-Canal, Javier Garcia-Frade, José Ramón González-Porras
Eltrombopag is effective and safe in immune thrombocytopenia (ITP). Some patients may sustain their platelet response when treatment is withdrawn but the frequency of this phenomenon is unknown. We retrospectively evaluated 260 adult primary ITP patients (165 women and 95 men; median age, 62 years) treated with eltrombopag after a median time from diagnosis of 24 months. Among the 201 patients who achieved a complete remission (platelet count >100 × 10(9) /l), eltrombopag was discontinued in 80 patients...
March 2015: American Journal of Hematology
Valentina Brunella, Maria Cristina Paganini
Three different samples of ultra high molecular weight polyethylene have been irradiated with a high energy source (electron beam), and radicals have been generated. Different radical species have been assigned on the basis of their electron paramagnetic resonance spectra. Electron paramagnetic resonance data have been used also to evaluate the amount of each kind of radical that has been generated on different starting materials. The structure of the polymer (number of double bonds or crystallinity) is strictly connected to the response of the sample itself to the irradiation...
March 2015: Magnetic Resonance in Chemistry: MRC
Luca Artiglia, Stefano Agnoli, Maria Cristina Paganini, Mattia Cattelan, Gaetano Granozzi
The Ce4+↔Ce3+ redox switch is at the basis of an all-inorganic catalytic cycle that is capable of mimicking the activity of several natural redox enzymes. The efficiency of these artificial enzymes (nanozymes) strongly depends on the Ce4+/Ce3+ ratio. By capitalizing on the results obtained on oxide/oxide model systems, we implemented a simple and effective procedure to obtain conformal TiO2@CeOx core-shell nanoparticles whose thickness is controlled with single-layer precision. Since the Ce3+ species are stabilized only at the interface by the electronic hybridization with the TiO2 states, the modulation of the shell thickness offers a simple method to tailor the Ce4+/Ce3+ ratio and therefore the catalytic properties...
November 26, 2014: ACS Applied Materials & Interfaces
Maria Cristina Paganini, Regina Szylit Bousso
BACKGROUND: The intensive care unit environment focuses on interventions and support therapies that prolong life. The exercise by nurses of their autonomy impacts on perception of the role they assume in the multidisciplinary team and on their function in the intensive care unit context. There is much international research relating to nurses' involvement in end-of-life situations; however, there is a paucity of research in this area in Brazil. In the Brazilian medical scenario, life support limitation generated a certain reluctance of a legal nature, which has now become unjustifiable with the publication of a resolution by the Federal Medical Council...
November 2015: Nursing Ethics
Chiara Gionco, Elio Giamello, Lorenzo Mino, Maria Cristina Paganini
The interaction of oxygen with the surface of CeO2-TiO2 mixed oxides prepared via sol-gel was investigated by means of electron paramagnetic resonance (EPR). Upon admission of molecular oxygen onto the surface of the as prepared materials (which underwent final oxidative calcination) the formation of superoxide O2(-) ions is observed without the need for preliminary annealing in a vacuum and consequent oxygen depletion. The superoxide species is symmetrically adsorbed ("side-on" structure) on the top of a Ce(4+) ion...
October 21, 2014: Physical Chemistry Chemical Physics: PCCP
Mario Chiesa, Maria Cristina Paganini, Stefano Livraghi, Elio Giamello
Electron Paramagnetic Resonance (EPR) techniques have been employed to investigate charge carrier trapping in the two main TiO2 polymorphs, anatase and rutile, with particular attention to the features of electron trapping sites (formally Ti(3+) ions). The classic CW-EPR technique in this case provides signals based on the g tensor only. Nevertheless a systematic analysis of the signals obtained in the various cases (anatase and rutile, surface and bulk centers, regular and defective sites) has been performed providing useful guidelines on a field affected by some confusion...
June 28, 2013: Physical Chemistry Chemical Physics: PCCP
Francesca R Grati, Francesca Malvestiti, Beatrice Grimi, Elisa Gaetani, Anna Maria Di Meco, Anna Trotta, Rosaria Liuti, Sara Chinetti, Francesca Dulcetti, Anna Maria Ruggeri, Cristina Agrati, Giuditta Frascoli, Silvia Milani, Simona De Toffol, Lorenza Martinoni, Silvia Paganini, Livia Marcato, Federico Maggi, Giuseppe Simoni
OBJECTIVES: Karyotyping on chorionic villous samples (CVS) includes the analysis of both cytotrophoblast (STC) and mesenchyme (LTC). This approach requires complex laboratory organization and trained technicians. The introduction of quantitative fluorescent polymerase chain reaction (QF-PCR) instead of conventional karyotyping in low-risk pregnancies opened its application in CVS analysis. Discordant QF-PCR and CVS cytogenetic results were reported, and strategies for CVS analysis were introduced to minimize this risk...
May 2013: Prenatal Diagnosis
Keite da Silva Nogueira, Maria Cristina Paganini, Andréia Conte, Laura Lúcia Cogo, Iara Taborda de Messias Reason, Márcio José da Silva, Libera Maria Dalla-Costa
BACKGROUND: Extended-spectrum β-lactamases (ESBLs) are increasingly prevalent in Enterobacter spp., posing a challenge to the treatment of infections caused by this microorganism. The purpose of this retrospective study was to evaluate the prevalence, risk factors, and clinical outcomes of inpatients with bacteremia caused by ESBL and non ESBL-producing Enterobacter spp. in a tertiary hospital over the period 2004-2008. METHODS: The presence of blaCTX-M, blaTEM, blaSHV, and blaPER genes was detected by polymerase chain reaction (PCR) and nucleotide sequence analysis...
February 2014: Enfermedades Infecciosas y Microbiología Clínica
Maria Cristina Paganini, Valentina Brunella, Mario Chiesa
Ultra high molecular weight polyethylene (UHMWPE) has been studied with different magnetic resonance techniques to elicit information on the nature and the location of radicals generated during high energy irradiation. Field swept electron paramagnetic resonance, pulsed Davies electron nuclear double resonance and hyperfine sublevel correlation spectroscopic measurements allowed extracting for the first time the full (1) H hyperfine coupling tensors of the most abundant radical, i.e. a secondary alkyl radical and to ascertain the formation of allyl radicals in the first stages of the irradiation process...
September 2012: Magnetic Resonance in Chemistry: MRC
Valentina Brunella, Maria Cristina Paganini
Electron paramagnetic resonance (EPR) technique has been employed to detect and characterise a series of different radical species generated in ultra-high molecular weight polyethylene (UHMWPE) via electron beam irradiation. Three different radical species have been found and assigned on the basis of their EPR spectra and of the related computer simulations. A secondary alkyl species, the prevalent one, is present immediately after irradiation, an allyl species appears only 24 h after irradiation when the alkyl species disappears...
September 2011: Magnetic Resonance in Chemistry: MRC
Stefano Livraghi, Sara Maurelli, Maria Cristina Paganini, Mario Chiesa, Elio Giamello
Reduced states in TiO(2) : (17)O hyperfine sublevel correlation spectroscopy was used to monitor the local environment of stable Ti(3+) ions generated in a (17)O-enriched polycrystalline TiO(2) (rutile) sample. A hyperfine interaction of about 8 MHz is found, which is analogous to that observed for molecular Ti(3+) aqua complex cations and suggests a localized nature of the unpaired electron wave function for these centers at 4 K.
August 22, 2011: Angewandte Chemie
Maria Cristina Paganini, Emiko Yoshikawa Egry
The purpose of this article is to initiate a philosophical discussion about the ethical component of professional competence in nursing from the perspective of Brazilian nurses. Specifically, this article discusses professional competence in nursing practice in the Brazilian health context, based on two different conceptual frameworks. The first framework is derived from the idealistic and traditional approach while the second views professional competence through the lens of historical and dialectical materialism theory...
July 2011: Nursing Ethics
Stefano Livraghi, Ingrid Corazzari, Maria Cristina Paganini, Giacomo Ceccone, Elio Giamello, Bice Fubini, Ivana Fenoglio
A safe UV filter may be obtained by inhibiting the photo-generation of free radicals through modification of the surface of TiO(2) nanoparticles with carbon.
November 28, 2010: Chemical Communications: Chem Comm
Maria Cristina Paganini
No abstract text is available yet for this article.
May 2010: Nursing Ethics
Karina Eugênia Schimith Bier, Simone Oliveira Luiz, Mara Cristina Scheffer, Ana Cristina Gales, Maria Cristina Paganini, Agnaldo José do Nascimento, Evelyn Carignano, Libera Maria Dalla Costa
BACKGROUND: In the last few years, carbapenem-resistant Acinetobacter baumannii isolates (CR-AB) have been identified worldwide. The first description of OXA-23-producing A baumannii in Brazil was from the city of Curitiba in 2003. The aim of the present study was to evaluate the persistence and dissemination of the first OXA-23-producing A baumannii clone isolated from patients in Hospital de Clinicas, Curitiba, Brazil. METHODS: An antimicrobial susceptibility profile of the isolates was determined by the standard agar dilution method...
May 2010: American Journal of Infection Control
Hugo Paganini, María P Della Latta, Beatriz Muller Opet, Gustavo Ezcurra, Macarena Uranga, Clarisa Aguirre, Gabriela Ensinck, Marys Kamiya de Macarrein, María R Miranda, Cristina Ciriaci, Claudia Hernández, Lidia Casimir, María J Rial, Norma Schenonne, Estela Ronchi, María del C Rodríguez, Fabiana Aprile, Catalina De Ricco, Viviana García Saito, Claudia Vrátnica, Laura Pons, Adriana Ernst, Sandra Morinigo, Marcelo Toffoli, Celia Bosque, Victoria Monzani, Andrea Mónaco, José L Pinheiro, María del P López, Leonardo Maninno, Claudia Sarkis
INTRODUCTION: Methicillin-resistant Staphylococcus aureus (MRSA) isolates are increasingly frequent causes of skin and soft-tissue infections or invasive infections in many communities. Local data are scarce. OBJECTIVE: To determine the frequency, clinical features and outcome of infections caused by MRSA. MATERIAL AND METHODS: Prospective and multicentric study of surveillance for community-acquired S. aureus infections in children from Argentina...
October 2008: Archivos Argentinos de Pediatría
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