Gregorio Romero-González, Néstor Rodríguez-Chitiva, Carles Cañameras, Javier Paúl-Martínez, Marina Urrutia-Jou, Maribel Troya, Jordi Soler-Majoral, Fredzzia Graterol Torres, Maya Sánchez-Bayá, Jordi Calabia, Jordi Bover
Kidneys have an amazing ability to adapt to adverse situations, both acute and chronic. In the presence of injury, the kidney is able to activate mechanisms such as autoregulation or glomerular hyperfiltration to maintain the glomerular filtration rate (GFR). While these adaptive mechanisms can occur in physiological situations such as pregnancy or high protein intake, they can also occur as an early manifestation of diseases such as diabetes mellitus or as an adaptive response to nephron loss. Although over-activation of these mechanisms can lead to intraglomerular hypertension and albuminuria, other associated mechanisms related to the activation of inflammasome pathways, including endothelial and tubular damage, and the hemodynamic effects of increased activity of the renin-angiotensin-aldosterone system, among others, are recognized pathways for the development of albuminuria...
January 29, 2024: Journal of Clinical Medicine