keyword
MENU ▼
Read by QxMD icon Read
search

Inflammasome and the kidneys

keyword
https://www.readbyqxmd.com/read/29742060/renal-involvement-in-autoinflammatory-diseases-and-inflammasome-mediated-chronic-kidney-damage
#1
REVIEW
Roberto Scarpioni, Laura Obici
Unprovoked activation of innate immune pathways and increased secretion of interleukin (IL)-1β and IL-18 are responsible for the protean clinical manifestations and the marked inflammatory response that characterise most hereditary autoinflammatory disorders. The kidney is a major target organ of this inflammatory process. The deposition of the acute-phase reactant serum amyloid A (SAA) as amyloid causes progressive glomerular and vascular damage and leads to organ failure. In this review we focus on the potential impact of hereditary autoinflammatory diseases on renal function, provide red flags that may guide the clinical suspicion of amyloid kidney damage and discuss the relevance of close renal monitoring for early diagnosis and prompt treatment...
January 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29740155/an-update-on-the-genetics-of-hyperuricaemia-and-gout
#2
REVIEW
Tanya J Major, Nicola Dalbeth, Eli A Stahl, Tony R Merriman
A central aspect of the pathogenesis of gout is elevated urate concentrations, which lead to the formation of monosodium urate crystals. The clinical features of gout result from an individual's immune response to these deposited crystals. Genome-wide association studies (GWAS) have confirmed the importance of urate excretion in the control of serum urate levels and the risk of gout and have identified the kidneys, the gut and the liver as sites of urate regulation. The genetic contribution to the progression from hyperuricaemia to gout remains relatively poorly understood, although genes encoding proteins that are involved in the NLRP3 (NOD-, LRR- and pyrin domain-containing 3) inflammasome pathway play a part...
May 8, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29682805/protective-effects-of-sarsasapogenin-against-early-stage-of-diabetic-nephropathy-in-rats
#3
Yao-Wu Liu, Yun-Chao Hao, Ya-Jing Chen, Shen-Yuan Yin, Meng-Ya Zhang, Li Kong, Tao-Yun Wang
Rhizome of Anemarrhena asphodeloides Bunge (AA, family Liliaceae) has been widely used in China for thousands of years to treat febrile diseases and diabetes. Steroidal saponins from AA show good antidiabetes effects and ameliorate diabetic complications. This study was designed to investigate the effects of sarsasapogenin (Sar), a major sapogenin from AA, on diabetic nephropathy (DN) in rats, and to explore the possible mechanisms. Diabetic rats were divided into 3 groups treated orally with Sar (0, 20, or 60 mg/kg) and carboxymethylcellulose sodium, whereas normal rats for Sar (0 or 60 mg/kg) and carboxymethylcellulose sodium...
April 23, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29605095/activated-renal-tubular-wnt-%C3%AE-catenin-signaling-triggers-renal-inflammation-during-overload-proteinuria
#4
Dickson W L Wong, Wai Han Yiu, Kam Wa Chan, Ye Li, Bin Li, Sarah W Y Lok, Makoto M Taketo, Peter Igarashi, Loretta Y Y Chan, Joseph C K Leung, Kar Neng Lai, Sydney C W Tang
Imbalance of Wnt/β-catenin signaling in renal cells is associated with renal dysfunction, yet the precise mechanism is poorly understood. Previously we observed activated Wnt/β-catenin signaling in renal tubules during proteinuric nephropathy with an unknown net effect. Therefore, to identify the definitive role of tubular Wnt/β-catenin, we generated a novel transgenic "Tubcat" mouse conditionally expressing stabilized β-catenin specifically in renal tubules following tamoxifen administration...
March 28, 2018: Kidney International
https://www.readbyqxmd.com/read/29592526/combination-exposure-of-melamine-and-cyanuric-acid-is-associated-with-polyuria-and-activation-of-nlrp3-inflammasome-in-rats
#5
Feifei Wang, Qiaojuan Liu, Lizi Jin, Shan Hu, Renfei Luo, Mengke Han, Yonggong Zhai, Weidong Wang, Chunling Li
The molecular mechanism of melamine-induced renal toxicity have not been fully understood. The purpose of the study aimed to investigate whether melamine and cyanuric acid induced NLRP3 inflammasome activation in the kidney, which may contribute to abnormal water and sodium handling in a rat model. Wistar rats were received melamine (Mel, 200 mg/kg BW/day), cyanuric acid (CA, 200 mg/kg BW/day), or Mel plus CA (Mel+CA, 100 mg/kg BW/day, each) for two weeks. Mel+CA caused damaged tubular epithelial structure and organelles, dilated tubular lumen, and inflammatory responses...
March 28, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29570768/tim-3-exacerbates-kidney-ischemia-reperfusion-injury-through-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway-and-an-nlrc4-inflammasome-activation
#6
Yunshan Guo, Jing Zhang, Xingqiang Lai, Miaojuan Chen, Yunshan Guo
T-cell immunoglobulin domain and mucin domain-containing molecule-3 (Tim-3) as a member of immunoglobulin superfamily, has been shown to play a crucial role in host adaptive immunity and tolerance. However, its role in kidney ischemia-reperfusion injury (IRI) remains unknown. In this study, we investigated the role and mechanism of Tim-3 signaling after kidney IRI. In an established murine model of kidney IRI, we found that Tim-3 expression is enhanced on monocytes/macrophages. Anti-Tim-3 Ab RMT3-23 ameliorates biochemical and histologic kidney injury, reduces apoptosis, decreases macrophage infiltration and cytokine production in ischemic kidneys...
March 23, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29543732/indoxyl-sulfate-promotes-macrophage-il-1%C3%AE-production-by-activating-aryl-hydrocarbon-receptor-nf-%C3%AE%C2%BA-mapk-cascades-but-the-nlrp3-inflammasome-was-not-activated
#7
Takuya Wakamatsu, Suguru Yamamoto, Toru Ito, Yoko Sato, Koji Matsuo, Yoshimitsu Takahashi, Yoshikatsu Kaneko, Shin Goto, Junichiro James Kazama, Fumitake Gejyo, Ichiei Narita
In chronic kidney disease (CKD) patients, accumulation of uremic toxins is associated with cardiovascular risk and mortality. One of the hallmarks of kidney disease-related cardiovascular disease is intravascular macrophage inflammation, but the mechanism of the reaction with these toxins is not completely understood. Macrophages differentiated from THP-1 cells were exposed to indoxyl sulfate (IS), a representative uremic toxin, and changes in inflammatory cytokine production and intracellular signaling molecules including interleukin (IL)-1, aryl hydrocarbon receptor (AhR), nuclear factor (NF)-κ, and mitogen-activated protein kinase (MAPK) cascades as well as the NLRP3 inflammasome were quantified by real-time PCR, Western blot analysis, and enzyme-linked immunosorbent assay...
March 15, 2018: Toxins
https://www.readbyqxmd.com/read/29535716/roles-of-macrophage-exosomes-in-immune-response-to-calcium-oxalate-monohydrate-crystals
#8
Nilubon Singhto, Rattiyaporn Kanlaya, Angkhana Nilnumkhum, Visith Thongboonkerd
In kidney stone disease, macrophages secrete various mediators via classical secretory pathway and cause renal interstitial inflammation. However, whether their extracellular vesicles, particularly exosomes, are involved in kidney stone pathogenesis remained unknown. This study investigated alterations in exosomal proteome of U937-derived macrophages (by phorbol-12-myristate-13-acetate activation) after exposure to calcium oxalate monohydrate (COM) crystals for 16-h using 2-DE-based proteomics approach. Six significantly altered proteins in COM-treated exosomes were successfully identified by nanoscale liquid chromatography-electrospray ionization-electron transfer dissociation tandem mass spectrometry as proteins involved mainly in immune processes, including T-cell activation and homeostasis, Fcγ receptor-mediated phagocytosis, interferon-γ (IFN-γ) regulation, and cell migration/movement...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29519318/kidney-protection-effects-of-dihydroquercetin-on-diabetic-nephropathy-through-suppressing-ros-and-nlrp3-inflammasome
#9
Tao Ding, Shaofei Wang, Xuyao Zhang, Wenjing Zai, Jiajun Fan, Wei Chen, Qi Bian, Jingyun Luan, Yilan Shen, Yanda Zhang, Dianwen Ju, Xiaobin Mei
BACKGROUND: Diabetic nephropathy (DN), the leading cause of end-stage renal disease, is acknowledged as an independent risk factor for cardiovascular disease, which underlines the urgent need for new medications to DN. Dihydroquercetin (DHQ), an important natural dihydroflavone, exerts significant antioxidant, anti-inflammatory, and antifibrotic properties, but its effects on DN have not been investigated yet. PURPOSE: We aimed to explore the kidney protection effects of DHQ on DN rats induced by high-fat diet/streptozotocin in vivo and the underlying mechanisms of DHQ on renal cells including HBZY-1 and HK2 exposed to high glucose in vitro...
March 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29518608/rip3-deficience-attenuates-potassium-oxonate-induced-hyperuricemia-and-kidney-injury
#10
Kang Wang, Lei Hu, Jian-Kang Chen
Recent preclinical and clinical evidence suggests that hyperuricemia (HU) is an independent risk factor for metabolic syndrome, hypertension, cardiovascular disease and chronic kidney disease. Receptor-interacting protein 3 (RIP3) is an important contributor in inducing programmed necrosis, representing a newly identified mechanism of cell death combining features of both apoptosis and necrosis. In our study, RIP3 was strongly expressed in mice with hyperuricemia. RIP3 deficiency attenuated hyperuricemia in mice, evidenced by reduced serum uric acid and creatinine and enhanced urinary uric acid and creatinine, as well as the improved histological alterations in renal sections...
May 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29514047/deletion-of-nlrx1-increases-fatty-acid-metabolism-and-prevents-diet-induced-hepatic-steatosis-and-metabolic-syndrome
#11
Lotte Kors, Elena Rampanelli, Geurt Stokman, Loes M Butter, Ntsiki M Held, Nike Claessen, Per W B Larsen, Joanne Verheij, Coert J Zuurbier, Gerhard Liebisch, Gerd Schmitz, Stephen E Girardin, Sandrine Florquin, Riekelt H Houtkooper, Jaklien C Leemans
NOD-like receptor (NLR)X1 (NLRX1) is an ubiquitously expressed inflammasome-independent NLR that is uniquely localized in mitochondria with as yet unknown effects on metabolic diseases. Here, we report that NLRX1 is essential in regulating cellular metabolism in non-immune parenchymal hepatocytes by decreasing mitochondrial fatty acid-dependent oxidative phosphorylation (OXPHOS) and promoting glycolysis. NLRX1 loss in mice has a profound impact on the prevention of diet-induced metabolic syndrome parameters, non-alcoholic fatty liver disease (NAFLD) progression, and renal dysfunction...
May 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29512688/in-vivo-effects-of-the-nlrp1-nlrp3-inflammasome-pathway-on-latent-respiratory-virus-infection
#12
Yong-Huai Li, Xiang Wei, Shuang Ji, Shu-Yu Gui, Su-Mei Zhang
The present study aimed to investigate the effects of nucleotide-binding domain leucine-rich repeat protein (NLRP)1/NLRP3 inflammasome pathways on latent viral infection of the respiratory tract. A total of 55 BALB/c mice were assigned to the control, bleomycin (BLM)‑treated, murine cytomegalovirus (MCMV), MCMV+BLM and MCMV+BLM+CD4+ T‑cell groups. The viral loads were detected in the salivary glands, kidney, liver and lung tissues via polymerase chain reaction (PCR). The weight, lung coefficient and hydroxyproline (HYP) were detected...
June 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29511302/nlrp3-inflammasome-inhibition-ameliorates-tubulointerstitial-injury-in-the-remnant-kidney-model
#13
Orestes Foresto-Neto, Victor Ferreira Ávila, Simone Costa Alarcon Arias, Fernanda Florencia Fregnan Zambom, Lisienny Campoli Tono Rempel, Viviane Dias Faustino, Flavia Gomes Machado, Denise Maria Avancini Costa Malheiros, Hugo Abensur, Niels Olsen Saraiva Camara, Roberto Zatz, Clarice Kazue Fujihara
Recent studies suggest that NLRP3 inflammasome activation is involved in the pathogenesis of chronic kidney disease (CKD). Allopurinol (ALLO) inhibits xanthine oxidase (XOD) activity, and, consequently, reduces the production of uric acid (UA) and reactive oxygen species (ROS), both of which can activate the NLRP3 pathway. Thus, ALLO can contribute to slow the progression of CKD. We investigated whether inhibition of XOD by ALLO reduces NLRP3 activation and renal injury in the 5/6 renal ablation (Nx) model...
March 6, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29508169/combined-sglt2-and-dpp4-inhibition-reduces-the-activation-of-the-nlrp3-asc-inflammasome-and-attenuates-the-development-of-diabetic-nephropathy-in-mice-with-type-2-diabetes
#14
Yochai Birnbaum, Mandeep Bajaj, Hsiu-Chiung Yang, Yumei Ye
BACGROUND: Sodium-glucose cotransporter 2 (SGLT2) inhibitors and dipeptidyl peptidase-4 inhibitors (DPP4I) are used to treat type 2 diabetes (T2DM). DPP4 inhibitors (DPP4) attenuate Nlrp3 inflammasome activation in the kidney. SGLT2 inhibition reduces inflammation and attenuates the progression of diabetic nephropathy (DN). The effects of dapagliflozin (Dapa) on the activation of the Nlrp3 inflammasome and the combined effect of SGLT2 and DPP4 on T2DM-induced inflammasome activation and progression of DN have not been previously studied...
March 5, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29500339/hydroxychloroquine-attenuates-renal-ischemia-reperfusion-injury-by-inhibiting-cathepsin-mediated-nlrp3-inflammasome-activation
#15
Tao-Tao Tang, Lin-Li Lv, Ming-Ming Pan, Yi Wen, Bin Wang, Zuo-Lin Li, Min Wu, Feng-Mei Wang, Steve D Crowley, Bi-Cheng Liu
Inflammation is a major contributor to the pathogenesis of ischemic acute kidney injury (AKI), which complicates the post-operative outcomes of large numbers of hospitalized surgical patients. Hydroxychloroquine (HCQ), a well-known anti-malarial drug, is commonly used in clinical practice for its anti-inflammatory actions. However, little is known about its role in renal ischemia/reperfusion (I/R) injury. In the current study, mice were subjected to I/R injury and HCQ was administered for seven days by gavage prior to surgery...
March 2, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29490620/development-of-tissue-inflammation-accompanied-by-nlrp3-inflammasome-activation-in-rabbits-infected-with-treponema-pallidum-strain-nichols
#16
Li-Rong Lin, Yao Xiao, Wei Liu, Yu-Yan Chen, Xiao-Zhen Zhu, Zheng-Xiang Gao, Kun Gao, Man-Li Tong, Hui-Lin Zhang, Shu-Lian Li, Hui-Ling Lin, Wen-Dong Li, Xian-Ming Liang, Yong Lin, Li-Li Liu, Tian-Ci Yang
BACKGROUND: The inflammasome responses in Treponema pallidum infection have been poorly understood to date. This study aimed to investigate the expression of the nucleotide-binding leucine-rich receptor protein 3 (NLRP3) inflammasome in the development of tissue inflammation in rabbits infected with T. pallidum. METHODS: Forty-five rabbits were randomly assigned to a blank group or an infection group, and the latter was divided into no benzathine penicillin G (BPG) and BPG treatment subgroups...
March 1, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29488356/p2x-7-receptor-antagonism-ameliorates-renal-dysfunction-in-a-rat-model-of-sepsis
#17
Nishkantha Arulkumaran, Marije L Sixma, Sean Pollen, Elias Ceravola, Elisa Jentho, Maria Prendecki, Paul S Bass, Frederick W K Tam, Robert J Unwin, Mervyn Singer
Sepsis is a major clinical problem associated with significant organ dysfunction and high mortality. The ATP-sensitive P2X7 receptor activates the NLRP3 inflammasome and is a key component of the innate immune system. We used a fluid-resuscitated rat model of fecal peritonitis and acute kidney injury (AKI) to investigate the contribution of this purinergic receptor to renal dysfunction in sepsis. Six and 24 h time-points were chosen to represent early and established sepsis, respectively. A selective P2X7 receptor antagonist (A-438079) dissolved in dimethyl sulfoxide (DMSO) was infused 2 h following induction of sepsis...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29477360/mros-txnip-axis-activates-nlrp3-inflammasome-to-mediate-renal-injury-during-ischemic-aki
#18
Yi Wen, Yi-Ran Liu, Tao-Tao Tang, Ming-Ming Pan, Sheng-Chun Xu, Kun-Ling Ma, Lin-Li Lv, Hong Liu, Bi-Cheng Liu
Ischemia/reperfusion (I/R) is a critical risk factor for acute kidney injury (AKI). Recent studies provided evidence that tubular epithelial cells (TEC)-associated inflammation aggravates kidney injury and impairs tissue repair after I/R injury. Here we demonstrated that the Nod-like receptor protein 3 (NLRP3) inflammasome is activated by mitochondrial reactive oxygen species (mROS) during I/R injury via direct interactions between the inflammasome and thioredoxin-interacting protein (TXNIP). Firstly, we found that NLRP3 inflammasome activation was induced by I/R injury, peaking at day 3 after reperfusion...
May 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29475133/reactive-oxygen-species-promote-tubular-injury-in-diabetic-nephropathy-the-role-of-the-mitochondrial-ros-txnip-nlrp3-biological-axis
#19
Yachun Han, Xiaoxuan Xu, Chengyuan Tang, Peng Gao, Xianghui Chen, Xiaofen Xiong, Ming Yang, Shikun Yang, Xuejing Zhu, Shuguang Yuan, Fuyou Liu, Li Xiao, Yashpal S Kanwar, Lin Sun
NLRP3/IL-1β activation via thioredoxin (TRX)/thioredoxin-interacting protein (TXNIP) following mitochondria ROS (mtROS) overproduction plays a key role in inflammation. However, the involvement of this process in tubular damage in the kidneys of patients with diabetic nephropathy (DN) is unclear. Here, we demonstrated that mtROS overproduction is accompanied by decreases in TRX expression and TXNIP up-regulation. In addition, we discovered that mtROS overproduction is also associated with increases in NLRP3/IL-1β and TGF-β expression in the kidneys of patients with DN and db/db mice...
June 2018: Redox Biology
https://www.readbyqxmd.com/read/29446486/interleukin-17a-participates-in-podocyte-injury-by-inducing-il-1%C3%AE-secretion-through-ros-nlrp3-inflammasome-caspase-1-pathway
#20
J Yan, Y Li, H Yang, L Zhang, B Yang, M Wang, Q Li
Studies show that the Th17/IL-17A axis plays an important role in the pathogenesis of kidney diseases. Previously, we also showed that IL-17A may play a role in the pathogenesis of primary nephrotic syndrome; however, the underlying mechanism(s) is unclear. The aim of this study was to explore the molecular mechanism of IL-17A-inducing podocyte injury in vitro. In this study, the NLRP3 inflammasome activation and the morphology of podocytes were detected by Western blot and immunofluorescence. The results showed that podocytes persistently expressed IL-17A receptor and that NLRP3 inflammasome in these cells was activated upon exposure to IL-17A...
April 2018: Scandinavian Journal of Immunology
keyword
keyword
54260
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"