keyword
MENU ▼
Read by QxMD icon Read
search

Osteoarthritis treatment

keyword
https://www.readbyqxmd.com/read/28738541/research-progress-on-osteoarthritis-treatment-mechanisms
#1
REVIEW
Yun-Yao Gu, Jian Chen, Zhu-Long Meng, Wan-Yu Ge, Yang-Yang Bian, Shao-Wen Cheng, Chen-Kun Xing, Jiang-Ling Yao, Jian Fu, Lei Peng
Osteoarthritis is a common disease and is frequently encountered in the older population; the incidence rises sharply with age. It is estimated that more than 360 million people suffer from OA. However, the pathogenesis of osteoarthritis remains unclear, and we cannot effectively prevent the progression of OA. The aim of this review was to explore the molecular markers and signaling pathways that induce chondrocyte apoptosis in OA. We searched, using the key words osteoarthritis, chondrocyte apoptosis, autophagy, endoplasmic reticulum stress, molecular targets, and biomarkers, in PubMed, Web of Science, and Google Scholar from 1994 to 2017...
July 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738432/the-stem-cell-market-for-the-treatment-of-knee-osteoarthritis-a-patient-perspective
#2
Nicolas S Piuzzi, Mitchell Ng, Morad Chughtai, Anton Khlopas, Kenneth Ng, Michael A Mont, George F Muschler
No abstract text is available yet for this article.
July 24, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28738079/comparison-between-intra-articular-ozone-and-placebo-in-the-treatment-of-knee-osteoarthritis-a-randomized-double-blinded-placebo-controlled-study
#3
Carlos César Lopes de Jesus, Fânia Cristina Dos Santos, Luciana Maria Oliveira Bueno de Jesus, Iara Monteiro, Maria Sonia Sousa Castro Sant'Ana, Virginia Fernandes Moça Trevisani
OBJECTIVE: The aim of the trial was to determine the effectiveness of oxygen-ozone injections on knee osteoarthritis concerning pain reduction, joint functional improvement, and quality of life. METHODS: In this randomized, double-blinded, placebo controlled clinical trial, 98 patients with symptomatic knee osteoarthritis (OA) were randomized into two groups receiving intra-articular 20 μg/ml of ozone (OZ) or placebo (PBO) for 8 weeks. The efficacy outcomes for knee OA were the Visual Analogue Scale (VAS), Lequesne Index, Timed Up and Go Test (TUG Test), SF-36, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Geriatric Pain Measure (GPM)...
2017: PloS One
https://www.readbyqxmd.com/read/28735841/the-perioperative-effects-of-chronic-preoperative-opioid-use-on-shoulder-arthroplasty-outcomes
#4
Jonathan W Cheah, David C Sing, Dell McLaughlin, Brian T Feeley, C Benjamin Ma, Alan L Zhang
HYPOTHESIS AND BACKGROUND: Chronic opioid therapy is an increasingly used modality for the treatment of osteoarthritis-associated pain. We hypothesized that chronic opioid use would be associated with adverse outcomes in shoulder arthroplasty. METHODS: A retrospective analysis of patients undergoing elective anatomic total shoulder arthroplasty (TSA) and reverse total shoulder arthroplasty (rTSA) at a single institution from 2012-2015 was performed. Patients were stratified by preoperative opioid use (nonusers, short-acting opioid users, and long-acting opioid users), and their postoperative clinical outcomes were assessed...
July 20, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28735822/conservative-management-of-a-traumatic-meniscal-injury-utilising-osteopathy-and-exercise-rehabilitation-a-case-report
#5
Jack Feehan, Chris Macfarlane, Brett Vaughan
Meniscal injury is one of the most common knee soft tissue injuries, commonly affecting young athletes and an older, degenerative population. Treatment largely depends on the type and extent of the injury with arthroscopic repair or meniscectomy being mainstays. Although non-surgical approaches have been described, there is no published literature regarding a combination of indirect osteopathic techniques and rehabilitation in the management of these injuries. The current case report follows a 20-year-old male presenting with a 5-day history of acute knee pain, following trauma during an Australian Rules Football (AFL) match...
August 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28733296/a-unified-multi-level-model-approach-to-assessing-patient-responsiveness-including-return-to-normal-minimally-important-differences-and-minimal-clinically-important-improvement-for-patient-reported-outcome-measures
#6
Adrian Sayers, Vikki Wylde, Erik Lenguerrand, Rachael Gooberman-Hill, Jill Dawson, David Beard, Andrew Price, Ashley W Blom
OBJECTIVE: This article reviews and compares four commonly used approaches to assess patient responsiveness with a treatment or therapy (return to normal (RTN), minimal important difference (MID), minimal clinically important improvement (MCII), OMERACT-OARSI [Outcome Measures in Rheumatology-Osteoarthris Reseach Society International] (OO)) and demonstrates how each of the methods can be formulated in a multilevel modelling (MLM) framework. DESIGN: Cohort study...
July 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28733093/hydrotherapy-improves-pain-and-function-in-older-women-with-knee-osteoarthritis-a-randomized-controlled-trial
#7
João Marcos Dias, Lígia Cisneros, Rosângela Dias, Carolina Fritsch, Wellington Gomes, Leani Pereira, Mary Luci Santos, Paulo Henrique Ferreira
BACKGROUND: Currently, there is poor evidence of the effect of hydrotherapy alone on patients with hip or knee osteoarthritis. OBJECTIVES: The study aimed to assess the impact of hydrotherapy on pain, function, and muscle function in older women with knee osteoarthritis. METHODS: A randomized controlled trial was conducted to evaluate the efficacy of hydrotherapy in women with knee osteoarthritis. Seventy-three women aged 65 and older were randomized to hydrotherapy (n=36) or a control group (n=37)...
July 5, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28732855/effects-of-thermosensitive-chitosan-gelatin-based-hydrogel-containing-glutathione-on-cisd2-deficient-chondrocytes-under-oxidative-stress
#8
Yung-Hsin Cheng, Eddy Chavez, Kun-Ling Tsai, Kai-Chiang Yang, Wei-Ting Kuo, Yi-Ping Yang, Shih-Hwa Chiou, Feng-Huei Lin
Aging is considered as a primary risk factor in the development of osteoarthritis (OA) which associated with mitochondrial dysfunction and oxidative stress. CDGSH iron sulfur domain 2 (Cisd2) deficiency causes mitochondrial dysfunction and drive premature aging. In the present study, thermosensitive chitosan-gelatin based hydrogel containing glutathione was developed as injectable drug delivery system for administration by minimal invasive surgery for the treatment of OA. Cisd2 deficiency (Cisd2(-/-)) mouse induced pluripotent stem cells-derived chondrocytes were established and characterized...
October 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28732700/evaluation-of-trabecular-structure-changes-in-osteoarthritis-of-the-temporomandibular-joint-with-cone-beam-computed-tomography-imaging
#9
Xin Liang, Shuming Liu, Xingmin Qu, Zhihui Wang, Jianbo Zheng, Xiaoyan Xie, Guowu Ma, Zuyan Zhang, Xuchen Ma
OBJECTIVES: To explore the possibility of using 2-dimensional image assessments in combination with cone beam computed tomography (CBCT) in patients with temporomandibular joint osteoarthritis (TMJOA) to enhance the clinical significance and applicability of the CBCT findings on TMJOA changes. STUDY DESIGN: Fifty-two patients with unilateral TMJOA and 40 healthy adults who had undergone CBCT in preparation for orthodontic treatment were selected for this study. Temporomandibular joint images were acquired with CBCT...
June 8, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28731170/isorhamnetin-inhibits-il%C3%A2-1%C3%AE-%C3%A2-induced-expression-of-inflammatory-mediators-in-human-chondrocytes
#10
Jin Li, Ruishan Wu, Xiaoping Qin, Dongyang Liu, Fenjie Lin, Qinglu Feng
Isorhamnetin (ISH) is a flavonoid primarily obtained from the fruit of Hippophae rhamnoides L., which possesses anti‑inflammatory properties. However, the effect of ISH on the expression of inflammatory mediators in response to interleukin (IL)‑1β stimulation has not been elucidated. The present study investigated the effects of ISH on the expression of inflammatory mediators in human chondrocytes, induced by IL‑1β. The results of the present study demonstrated that pretreatment with ISH inhibited the expression of stromelysin‑1 and collagenase 3 in chondrocytes, induced by IL‑1β...
July 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28730727/better-arthritis-care-patients-expectations-and-priorities-the-competencies-that-community-based-health-professionals-need-to-improve-their-care-of-people-with-arthritis
#11
J Erwin, K Edwards, A Woolf, S Whitcombe, S Kilty
OBJECTIVE: The aim of the present study was to identify the competencies that patients think non-specialist community-based nurses and allied health professionals (AHPs) need to enable them to assess, care for and manage arthritis appropriately. METHODS: Four face-to-face focus groups were held with a total of 16 women and nine men with arthritis, to discuss the care they received from community-based health professionals, the skills and knowledge they expected from community-based health professionals and what they prioritized...
July 21, 2017: Musculoskeletal Care
https://www.readbyqxmd.com/read/28730231/chondroprotective-effects-of-pulsed-shortwave-therapy-in-rabbits-with-experimental-osteoarthritis
#12
Rodica Ana Ungur, Adrian Florea, Alexandru Flaviu Tăbăran, Iuliu Călin Scurtu, Ioan Onac, Ileana Monica Borda, László Irsay, Viorela Mihaela Ciortea, Eleonora Dronca, Mihnea Tudor Zdrenghea, ŞoimiŢa Mihaela Suciu
INTRODUCTION: Osteoarthritis (OA) represents a public health challenge since the pathogenic treatment, able to induce cartilage regeneration, still remains unknown. Ageing of the population and increasing OA prevalence have led to a lot of research, aiming to identify treatments acting on chondrocytes that play a determinant role in cartilage degeneration÷regeneration balance. Pulsed shortwave therapy (with the classical application form - Diapulse) is a physiotherapy method with anabolic effects demonstrated on nervous, conjunctive and vascular tissues, but its effects on OA cartilage are not known...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28729949/modeling-the-effect-of-blunt-impact-on-mitochondrial-function-in-cartilage-implications-for-development-of-osteoarthritis
#13
Georgi I Kapitanov, Bruce P Ayati, James A Martin
OBJECTIVE: Osteoarthritis (OA) is a disease characterized by degeneration of joint cartilage. It is associated with pain and disability and is the result of either age and activity related joint wear or an injury. Non-invasive treatment options are scarce and prevention and early intervention methods are practically non-existent. The modeling effort presented in this article is constructed based on an emerging biological hypothesis-post-impact oxidative stress leads to cartilage cell apoptosis and hence the degeneration observed with the disease...
2017: PeerJ
https://www.readbyqxmd.com/read/28728848/endoplasmic-reticulum-stress-participates-in-the-progress-of-senescence-and-apoptosis-of-osteoarthritis-chondrocytes
#14
Yake Liu, Hai Zhu, Xin Yan, Haoye Gu, Zhifeng Gu, Fan Liu
Endoplasmic reticulum stress (ERS) has been shown to participate in many disease pathologies. Recent reports have reported that ERS exists in human osteoarthritis (OA) chondrocytes. During OA, chondrocytes exhibit increased level of some senescence marker, such as senescence-associated β-galactosidase (SA β-gal) activity. However, the persistence and accumulation of senescent cells in various tissues can also impair function and have been involved in the pathogenesis of many age-related diseases, including OA...
July 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28728820/role-of-piezo-channels-in-joint-health-and-injury
#15
W Lee, F Guilak, W Liedtke
Cartilage is an intrinsically mechanically sensitive tissue composed of chondrocytes as the only cell type. Chondrocyte mechanotransduction is not well understood, but recently we identified critical components of the mechanotransduction machinery demonstrating how mechanical stimulation of these cells can be converted into cellular calcium signals. Physiologic mechanical cues induce anabolic responses of (post-mitotic) chondrocytes via transient receptor potential vanilloid 4 ion channels, whereas injurious mechanical stress is transduced by Piezo1 jointly with Piezo2 ion channels...
2017: Current Topics in Membranes
https://www.readbyqxmd.com/read/28728606/levels-of-serum-biomarkers-from-a-two-year-multicentre-trial-are-associated-with-treatment-response-on-knee-osteoarthritis-cartilage-loss-as-assessed-by-magnetic-resonance-imaging-an-exploratory-study
#16
Johanne Martel-Pelletier, Jean-Pierre Raynauld, François Mineau, François Abram, Patrice Paiement, Philippe Delorme, Jean-Pierre Pelletier
BACKGROUND: There is an obvious need to identify biomarkers that could predict patient response to an osteoarthritis (OA) treatment. This post hoc study explored in a 2-year randomized controlled trial in patients with knee OA, the likelihood of some serum biomarkers to be associated with a better response to chondroitin sulfate in reducing cartilage volume loss. METHODS: Eight biomarkers were studied: hyaluronic acid (HA), C reactive protein (CRP), adipsin, leptin, N-terminal propeptide of collagen IIα (PIIANP), C-terminal crosslinked telopeptide of type I collagen (CTX-1), matrix metalloproteinase-1 (MMP-1), and MMP-3...
July 20, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28728078/femoral-head-necrosis-a-finite-element-analysis-of-common-and-novel-surgical-techniques
#17
Myriam Cilla, Sara Checa, Bernd Preininger, Tobias Winkler, Carsten Perka, Georg N Duda, Matthias Pumberger
BACKGROUND: Femoral head necrosis is a common cause of secondary osteoarthritis. At the early stages, treatment strategies are normally based on core decompression techniques, where the number, location and diameter of the drilling holes varies depending on the selected approach. The purpose of this study was to investigate the risk of femoral head, neck and subtrochanteric fracture following six different core decompression techniques. MATERIALS: Five common and a newly proposed techniques were analyzed in respect to their biomechanical consequences using finite element analysis...
July 6, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28727103/effects-of-dietary-calcium-fructoborate-supplementation-on-joint-comfort-and-flexibility-and-serum-inflammatory-markers-in-dogs-with-osteoarthritis
#18
A K Price, M R C de Godoy, T A Harper, K E Knap, S Joslyn, Z Pietrzkowski, B K Cross, K B Detweiler, K S Swanson
Our objective was to evaluate the short-term effects of calcium fructoborate (CFB) on gait, joint range of motion, serum inflammatory markers, and owner perception of pain in client-owned dogs. We used 59 osteoarthritic dogs with impairment, with dogs being randomly assigned to 4 treatments: placebo (60 mg fructose; = 15), low dose (69 mg CFB; = 14), high dose (127 mg CFB; = 14), or combination (69 mg CFB, 500 mg glucosamine hydrochloride and 200 mg chondroitin sulfate; = 16). Dogs up to 22.9 kg received 1 capsule/d, while dogs weighing 23 to 50 kg received 2 capsules/d...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726510/the-effect-of-probiotic-lactobacillus-casei-shirota-on-knee-osteoarthritis-a-randomised-double-blind-placebo-controlled-clinical-trial
#19
M Lei, C Guo, D Wang, C Zhang, L Hua
Knee osteoarthritis (OA) treatment is challenging due to inefficacy and adverse effects of current medications. Probiotic treatment has been shown to promote bone metabolism, reduce pain and inflammatory responses of age-related musculoskeletal disorders, including OA. We aimed to investigate the effect of probiotic Lactobacillus casei Shirota (LcS) on patients with knee OA. 537 patients with knee OA were enrolled in this double-blind, placebo-controlled trial, who were randomised to receive skimmed milk containing either LcS or placebo daily for 6 months...
July 20, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28725633/exploiting-leech-saliva-to-treat-osteoarthritis-a-provocative-perspective
#20
Edwin L Cooper, Natalie Mologne
Plant and animal-derived products are crucial components in complementary and alternative medicine. Although modern medicine has provided numerous innovations and advancements, these often fail to reveal new and dependable, inexpensive treatments nor real cures that are relatively free of adverse side effects. We present evidence that hirudotherapy, which utilizes leeches, improves certain diseases, including osteoarthritis. Osteoarthritis, a disease in joints, could benefit from use of medicinal peptides found in leech saliva, components of its immune system...
July 2017: Journal of Traditional and Complementary Medicine
keyword
keyword
54259
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"