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Osteoarthritis treatment

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https://www.readbyqxmd.com/read/28647729/analgesic-effects-of-diluted-bee-venom-acupuncture-mediated-by-%C3%AE-opioid-and-%C3%AE-2-adrenergic-receptors-in-osteoarthritic-rats
#1
Jeong-Eun Huh, Byung-Kwan Seo, Jung-Woo Lee, Yeon-Cheol Park, Yong-Hyeon Baek
Context • Pain from osteoarthritis is associated with peripheral nociception and central pain processing. Given the unmet need for innovative, effective, and well-tolerated therapies, many patients, after looking for more satisfactory alternatives, decide to use complementary and alternative modalities. The analgesic mechanism of subcutaneous injections of diluted bee venom into an acupoint is thought to be part of an anti-inflammatory effect and the central modulation of pain processing. Objectives • Using the rat model of collagenase-induced osteoarthritis (CIOA), the study intended to investigate the analgesic effects of bee venom acupuncture (BVA) as they are related to the acupuncture points and dosage used and to determine whether the analgesic mechanisms of BVA for pain were mediated by opioid or adrenergic receptors...
June 23, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28647718/new-meniscal-tears-after-acl-injury-what-is-the-risk-a-systematic-review-protocol
#2
REVIEW
Guri Ranum Ekås, Clare Ardern, Hege Grindem, Lars Engebretsen
BACKGROUND: Secondary meniscal tears after ACL injuries increase the risk of knee osteoarthritis. The current literature on secondary meniscal injuries after ACL injury is not consistent and may have methodological shortcomings. This protocol describes the methods of a systematic review investigating the rate of secondary meniscal injuries in children and adults after treatment (operative or non-operative) for ACL injury. METHODS: We will search electronic databases (Embase, Ovid Medline, Cochrane, CINAHL (Cumulative Index to Nursing and Allied Health Literature), SPORTDiscus, PEDro and Google Scholar) from database inception...
June 24, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28647370/oleanolic-acid-prevents-cartilage-degeneration-in-diabetic-mice-via-ppar%C3%AE-associated-mitochondrial-stabilization
#3
Xia Kang, Zhikui Yang, Jun Sheng, Jin-Biao Liu, Qing-Yun Xie, Wei Zheng, Ken Chen
Hyperglycemia-induced cartilage degeneration induces osteoarthritis (OA). Since oleanolic acid (OLA) have several pharmacological effects such as anti-inflammatory, anti-oxidant, we hypothesized it possesses protection against high glucose injured cartilage. We now report that OLA decreased type X collagen and reversed the cartilage degeneration in growth plate from db/db mice. OLA increased type Ⅱ collagen expression in a concentration-dependent manner (10-50 μΜ) in high glucose-treated chondrocytes. OLA prevented the high glucose induced cell injury and decreased the level of MMP-13, PGE2 and IL-6 due to decreasing mitochondrial membrane potential and stimulated the ATP production...
June 21, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28645770/the-association-between-sedentary-time-and-quality-of-life-from-the-osteoarthritis-initiative-who-might-benefit-most-from-treatment
#4
Daniel Pinto, Jing Song, Jungwha Lee, Rowland W Chang, Pamela A Semanik, Linda S Ehrlich-Jones, Christine A Pellegrini, Dorothy D Dunlop
OBJECTIVE: To investigate the relationship between sedentary behavior and quality adjusted life years (QALY) among participants in the Osteoarthritis Initiative (OAI). DESIGN: 1794 participants from a prospective multicenter, longitudinal cohort were classified into quantile groups based on average daily sedentary time (most sedentary Q1 >=11.6, 10.7<=Q2<11.6, 9.7<=Q3<10.7, least sedentary Q4<9.7 average daily sedentary hours). INTERVENTIONS: None...
June 20, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28645453/choice-of-knee-cartilage-thickness-change-metric-for-different-treatment-goals-in-efficacy-studies
#5
Robert J Buck, Marie-Pierre Hellio Le Graverand, Wolfgang Wirth, Felix Eckstein
INTRODUCTION: In knee osteoarthritis, local increase and decrease in cartilage thickness has been observed over short time intervals. Hence, averaging cartilage change across large regions may not capture the complexity of structural alterations in disease progression. This study aims to examine the relative performance of different metrics of cartilage thickness change for different clinical studies scenarios. MATERIALS AND METHODS: Metrics for assessing cartilage thickness change were characterized by conventional measures of change versus absolute values (the magnitude) of change, and by different methods of summarizing change over (sub-) regions...
May 30, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28645132/platelet-rich-plasma-for-the-treatment-of-knee-osteoarthritis-a-review
#6
Nicolas S Piuzzi, Morad Chughtai, Anton Khlopas, Steven F Harwin, Anthony Miniaci, Michael A Mont, George F Muschler
No abstract text is available yet for this article.
June 23, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28644942/total-wrist-arthroplasty-versus-wrist-fusion-utilization-and-complication-rates-as-reported-by-abos-part-ii-candidates
#7
Richard M Hinds, John T Capo, Marco Rizzo, James R Roberson, Michael B Gottschalk
BACKGROUND: The aim of this study was to assess national trends in the utilization and complication rates of total wrist arthroplasty (TWA) and total wrist fusion (WF) as identified via review of the American Board of Orthopedic Surgery (ABOS) Part II candidate database. METHODS: The ABOS Part II candidate database is a collection of cases reported by candidates of the ABOS Part II board certification oral exam. The ABOS database was queried for all TWA and WF cases performed from 2005 to 2014...
July 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28644392/development-of-bone-targeting-drugs
#8
REVIEW
Molly Stapleton, Kazuki Sawamoto, Carlos J Alméciga-Díaz, William G Mackenzie, Robert W Mason, Tadao Orii, Shunji Tomatsu
The skeletal system, comprising bones, ligaments, cartilage and their connective tissues, is critical for the structure and support of the body. Diseases that affect the skeletal system can be difficult to treat, mainly because of the avascular cartilage region. Targeting drugs to the site of action can not only increase efficacy but also reduce toxicity. Bone-targeting drugs are designed with either of two general targeting moieties, aimed at the entire skeletal system or a specific cell type. Most bone-targeting drugs utilize an affinity to hydroxyapatite, a major component of the bone matrix that includes a high concentration of positively-charged Ca(2+)...
June 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28643827/anti-oxidant-and-immune-modulatory-properties-of-sulfated-alginate-derivatives-on-human-chondrocytes-and-macrophages
#9
Anne Kerschenmeyer, Øystein Arlov, Vera Malheiro, Matthias Steinwachs, Markus Rottmar, Katharina Maniura-Weber, Gemma Palazzolo, Marcy Zenobi-Wong
Degeneration of articular cartilage represents one of the most common causes of pain and disability in our aging society. Current treatments only address the symptoms of joint disease, but not their underlying causes which include oxidative stress and inflammation in cartilage and surrounding tissues. Sulfated biopolymers that mimic aspects of the native extracellular environment of cartilage are recently gaining interest as a means to slow the inflammatory events responsible for tissue degeneration. Here we show that the natural polysaccharide alginate and particularly its sulfated derivatives have potent anti-oxidant, anti-inflammatory and anti-immunogenic properties in vitro...
June 23, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28643466/anemonin-attenuates-osteoarthritis-progression-through-inhibiting-the-activation-of-il-1%C3%AE-nf-%C3%AE%C2%BAb-pathway
#10
Zuqiang Wang, Junlan Huang, Siru Zhou, Fengtao Luo, Wei Xu, Quan Wang, Qiaoyan Tan, Liang Chen, Jun Wang, Hangang Chen, Lin Chen, Yangli Xie, Xiaolan Du
The osteoarthritis (OA) progression is now considered to be related to inflammation. Anemonin (ANE) is a small natural molecule extracted from various kinds of Chinese traditional herbs and has been shown to inhibiting inflammation response. In this study, we examined whether ANE could attenuate the progression of OA via suppression of IL-1β/NF-κB pathway activation. Destabilization of the medial meniscus (DMM) was performed in 10-week-old male C57BL/6J mice. ANE was then intra-articularly injected into joint capsule for 8 and 12 weeks...
June 23, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28642490/relationship-between-kellgren-lawrence-score-and-3d-kinematic-gait-analysis-of-patients-with-medial-knee-osteoarthritis-using-a-new-gait-system
#11
Xiaolong Zeng, Limin Ma, Zefeng Lin, Wenhan Huang, Zhiqiang Huang, Yu Zhang, Chuanbin Mao
Knee osteoarthritis (KOA) is reported to have characteristic kinematics during walking. However, the relationship between Kellgren-Lawrence (K/L) score and the 3D kinematic gait of patients with medial KOA remains unclear. Here, ninety-seven patients with medial KOA and thirty-eight asymptomatic participants were involved. Patients with medial KOA were divided into early, moderate, and severe KOA based on the K/L score. Through kinematic gait analysis, we found a relationship between K/L score and 3D kinematic gait for patients...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28642243/anti-inflammatory-and-anti-osteoarthritis-effects-of-tectorigenin
#12
Cheng-Long Wang, De Li, Chuan-Dong Wang, Fei Xiao, Jun-Feng Zhu, Chao Shen, Bin Zuo, Yi-Min Cui, Hui Wang, Yuan Gao, Guo-Li Hu, Xiao-Ling Zhang, Xiao-Dong Chen
Osteoarthritis (OA) is a common and dynamic joint disease, including the articular cartilage, underlying bones, and synovium. In particular, OA is considered as the degeneration of the cartilage. Tectorigenin (Tec) can affect many biological processes. However, its effect on articular chondrocytes remains unclear. This study aimed to assess the role of Tec in articular cartilage. In vitro, Tec inhibited the expression levels of type X collagen, cyclooxigenase-2, matrix metalloproteinase (MMP)-3, and MMP-13 gene but enhanced those of Runx1, type II collagen, and aggrecan in the presence of IL-1β...
June 22, 2017: Biology Open
https://www.readbyqxmd.com/read/28642164/joint-loading-and-proximal-tibia-subchondral-trabecular-bone-microarchitecture-differ-with-walking-gait-patterns-in-end-stage-knee-osteoarthritis
#13
Bryant C Roberts, Lucian B Solomon, Graham Mercer, Karen J Reynolds, Dominic Thewlis, Egon Perilli
OBJECTIVES: To (1) stratify subgroups according to their distinct walking gait patterns in end-stage knee osteoarthritis (OA) patients; (2) compare measures of joint loading and proximal tibia subchondral trabecular bone (STB) microarchitecture among subgroups. DESIGN: Twenty-five knee OA patients undergoing total knee arthroplasty had pre-operative gait analysis. Following surgery, excised tibial plateaus were micro-CT-scanned and STB microarchitecture analysed in four tibial condylar regions of interest...
June 19, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28640896/beneficial-effects-of-a-gait-used-while-wearing-a-kimono-to-decrease-the-knee-adduction-moment-in-healthy-adults
#14
Susumu Ota, Yukari Ogawa, Hiroki Ota, Tomoya Fujiwara, Tadashi Sugiyama, Akira Ochi
The knee adduction moment (KAM) relates to medial knee osteoarthritis (OA). Several gait modifications to reduce the KAM for the prevention of knee OA have been studied. Most of the modifications, however, involve voluntary changes in leg alignment. Here we investigated the biomechanical effects for reducing the KAM of a walking style with a small trunk rotation and arm swing gait, which is a natural walking style used while wearing a kimono (Nanba walk) that shifts the ground reaction force toward the stance leg (reduced lever arm)...
2017: PloS One
https://www.readbyqxmd.com/read/28640163/mistletoe-fig-ficus-deltoidea-jack-leaf-extract-prevented-postmenopausal-osteoarthritis-by-attenuating-inflammation-and-cartilage-degradation-in-rat-model
#15
Nur Adeelah Che Ahmad Tantowi, Paisal Hussin, Seng Fong Lau, Suhaila Mohamed
OBJECTIVE: Ficus deltoidea Jack (mistletoe fig) is an ornamental plant found in various parts of the world and used as traditional herbal medicine in some countries. This study investigated the potential use of F deltoidea leaf extract to mitigate osteoarthritis (OA) in ovariectomized (estrogen-deficient postmenopausal model) rats and the mechanisms involved. Diclofenac was used for comparison. METHODS: Sprague-Dawley female rats (12 weeks old) were divided randomly into five groups (n = 6): healthy; nontreated OA; OA + diclofenac (5 mg/kg); OA + extract (200 mg/kg); and OA + extract (400 mg/kg)...
June 19, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28639519/knee-joint-kinetics-in-response-to-multiple-three-dimensional-printed-customised-foot-orthoses-for-the-treatment-of-medial-compartment-knee-osteoarthritis
#16
Richard Allan, James Woodburn, Scott Telfer, Mandy Abbott, Martijn Pm Steultjens
The knee adduction moment is consistently used as a surrogate measure of medial compartment loading. Foot orthoses are designed to reduce knee adduction moment via lateral wedging. The 'dose' of wedging required to optimally unload the affected compartment is unknown and variable between individuals. This study explores a personalised approach via three-dimensional printed foot orthotics to assess the biomechanical response when two design variables are altered: orthotic length and lateral wedging. Foot orthoses were created for 10 individuals with symptomatic medial knee osteoarthritis and 10 controls...
June 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28638242/cost-utility-of-a-single-injection-combined-corticosteroid-hyaluronic-acid-formulation-vs-a-2-injection-regimen-of-sequential-corticosteroid-and-hyaluronic-acid-injections
#17
Etienne L Belzile, Robert T Deakon, Christopher Vannabouathong, Mohit Bhandari, Martin Lamontagne, Robert McCormack
Research has shown early and sustained relief with a combination therapy of a corticosteroid (CS) and hyaluronic acid (HA) in knee osteoarthritis (OA) patients. This can be administered via a single injection containing both products or as separate injections. The former may be more expensive when considering only product cost, but the latter incurs the additional costs and time of a second procedure. The purpose of this study was to compare the cost-utility of the single injection with the 2-injection regimen...
2017: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28638116/laser-ultrasonic-delivery-of-agents-into-articular-cartilage
#18
Heikki J Nieminen, Gonçalo Barreto, Mikko A Finnilä, Alejandro García-Pérez, Ari Salmi, Sanjeev Ranjan, Kari K Eklund, Kenneth P H Pritzker, Simo Saarakkala, Edward Hæggström
Research is ongoing to develop drug therapies to manage osteoarthritis (OA) and articular cartilage (AC) injuries. However, means to deliver drug to localized AC lesions are highly limited and not clinically available. This study investigates the capability of laser ultrasound (laser-induced plasma sound source) to deliver agents (methylene blue, MB, in PBS) into bovine AC. Treatment samples (n = 10) were immersed in MB solution simultaneously with LU exposure, while adjacent control 1 tissue (n = 10) was pre-treated with LU followed by immersion in MB and adjacent control 2 tissue (n = 10) was only immersed in MB...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28636468/do-ligamentum-teres-tears-portend-inferior-outcomes-in-patients-with-borderline-dysplasia-undergoing-hip-arthroscopic-surgery-a-match-controlled-study-with-a-minimum-2-year-follow-up
#19
Edwin O Chaharbakhshi, Itay Perets, Lyall Ashberg, Brian Mu, Christopher Lenkeit, Benjamin G Domb
BACKGROUND: Arthroscopic surgery in borderline dysplastic hips remains controversial, but the role of the ligamentum teres (LT) has not been studied in this setting. HYPOTHESIS: Borderline dysplastic patients with LT tears have worse short-term outcomes than those without LT tears. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: Data were prospectively collected on patients who underwent arthroscopic surgery between February 2008 and April 2014...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28634785/-imaging-and-preoperative-planning-for-osteotomies-around-the-knee
#20
REVIEW
D Pape, A Hoffmann, R Seil
Physiologic alignment of the human lower leg is well defined. The etiology for malalignment comprises constitutional, degenerative and posttraumatic conditions. Osteotomies around the knee can correct the malalignment, provided that the origin of deviation is in proximity of the knee center. Crucial factors for the evaluation of axis deviation are the weight-bearing line, the mechanical axes of femur and tibia, the joint line angles and the center of the hip, knee and upper ankle joint. Careful preoperative planning is mandatory for reproducible clinical results...
June 20, 2017: Operative Orthopädie und Traumatologie
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