keyword
https://read.qxmd.com/read/38535359/fatty-acid-profile-and-escherichia-coli-and-salmonella-sp-load-of-wild-caught-seaweed-fly-fucellia-maritima-haliday-1838-diptera-anthomyiidae
#1
JOURNAL ARTICLE
Felipe Lourenço, Ricardo Calado, Marisa Pinho, Maria Rosário Domingues, Isabel Medina, Olga M C C Ameixa
World aquaculture is expected to continue to grow over the next few decades, which amplifies the need for a higher production of sustainable feed ingredients for aquatic animals. Insects are considered good candidates for aquafeed ingredients because of their ability to convert food waste into highly nutritional biomass. However, commercially available terrestrial insect species lack n-3 long-chain polyunsaturated fatty acids (LC-PUFAs), which are essential biomolecules for marine cultured species. Nevertheless, several coastal insect species feature LC-PUFAs in their natural fatty acid (FA) profile...
February 28, 2024: Insects
https://read.qxmd.com/read/38530954/differences-in-plasma-fatty-acid-composition-related-to-chronic-pancreatitis-a-pilot-study
#2
JOURNAL ARTICLE
Kristyn Gumpper-Fedus, Olivia Crowe, Phil A Hart, Valentina Pita-Grisanti, Ericka Velez-Bonet, Martha A Belury, Mitchell L Ramsey, Rachel M Cole, Niharika Badi, Stacey Culp, Alice Hinton, Luis F Lara, Somashekar G Krishna, Darwin L Conwell, Zobeida Cruz-Monserrate
OBJECTIVES: Chronic pancreatitis (CP) is an inflammatory disease affecting the absorption of fat-soluble nutrients. Signaling in pancreatic cells that lead to inflammation may be influenced by fatty acids (FAs) through diet and de novo lipogenesis. Here, we investigated the relationship between plasma FA composition in CP with heterogeneity of etiology and complications of CP. MATERIALS AND METHODS: Blood and clinical parameters were collected from subjects with CP (n = 47) and controls (n = 22)...
March 13, 2024: Pancreas
https://read.qxmd.com/read/38529280/the-causal-relationship-between-serum-metabolites-and-the-risk-of-psoriasis-a-mendelian-randomization-and-meta-analysis-study
#3
JOURNAL ARTICLE
Yujie Yang, Xuwei Zheng, Haiying Lv, Bin Tang, Yiyuan Zhong, Qianqian Luo, Yang Bi, Kexin Yang, Haixin Zhong, Haiming Chen, Chuanjian Lu
OBJECTIVE: To explore the influence of serum metabolites on the risk of psoriasis. METHODS: In the initial stage, we applied Mendelian randomization to evaluate the association between 1,400 serum metabolites and the risk of psoriasis. Causal effects were primarily assessed through the Inverse-Variance Weighted method and Wald Ratio's odds ratios, and 95% confidence intervals. False Discovery Rate was used for multiple comparison corrections. Sensitivity analyses were conducted using Cochran's Q Test, MR-PRESSO...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38529194/quality-changes-in-chinese-high-quality-indica-rice-under-different-storage-temperatures-with-varying-initial-moisture-contents
#4
JOURNAL ARTICLE
Dongyi Zhu, Tingting Wang, Xiuying Liu, Jie Bi, Wei Zhang, Xuefeng Zeng, Pingping Wang, Zaixi Shu
The planting area of high-quality indica rice varieties has been growing rapidly in China. However, the storage characteristics of these varieties remains unclear. In this research, different moisture contents (13.5, 14.5, and 15.5%) of high-quality rice (variety Xiadao No.1) were stored at different temperatures (15, 20, 25, and 30°C) for 360 d, and then evaluated for lipid metabolism, redox enzyme activities, fatty acid composition, and sensory attributes. With the prolongation of storage, rice displayed an upward trend in fatty acid value, malondialdehyde content, and cooked rice hardness and a downward trend in contents of total fat and non-starch lipid, peroxidase and catalase activities, and sensory score of cooked rice...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38528432/growth-performance-plasma-metabolites-meat-quality-and-meat-and-lipid-health-indices-of-new-zealand-white-rabbits-as-affected-by-dietary-dried-tomato-pomace-powder-supplementation-during-the-summer-season
#5
JOURNAL ARTICLE
Fawzia A Hassan, Manal S Mohamed, Doaa O Othman, Shawky A El-Medany, Rehab Ismail, Balasubramanian Balalmuralikrishnan, Rashed A Alhotan, Youssef A Attia, Fulvia Bovera, Khalid Mahrose
One hundred and twenty New Zealand White rabbits (NZW) (5-week-old; 735.27 ± 27.23 g) were kept in an open-sided house during the summer season. The experiment aims to evaluate the impacts of dried tomato pomace powder (DTPP) supplementation on rabbits' performance, blood metabolites, carcass traits, meat quality, and lipid and health indices of NZW rabbits during 5-13 weeks of age. The four treatments were a standard rabbit feed (control) and the control diet supplemented with 0.5, 1...
March 25, 2024: Journal of Animal Physiology and Animal Nutrition
https://read.qxmd.com/read/38528041/investigation-the-biological-activities-and-the-metabolite-profiles-of-endophytic-fungi-isolated-from-gundelia-tournefortii-l
#6
JOURNAL ARTICLE
Mostafa Ebadi, Fatemeh Ahmadi, Hossein Tahmouresi, Mohammad Pazhang, Saeed Mollaei
Endophytic fungi are microorganisms that are considered as a potential source of natural compounds, and can be applied in various industries. The aims of this research were molecular identification of endophytic fungi isolated from the Gundelia tournefortii stems, and investigation their biological activities as well as phenolic and fatty acid profile. Surface sterilized stems of G. tournefortii were placed on potato dextrose agar (PDA) to isolate the fungal endophytes. Genomic DNA was extracted by CTAB method, and PCR amplification was performed by ITS 1 and ITS 4 as primers...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38527055/inflammatory-response-in-dairy-cows-caused-by-heat-stress-and-biological-mechanisms-for-maintaining-homeostasis
#7
JOURNAL ARTICLE
Hana Kim, Jang-Hoon Jo, Hong-Gu Lee, Woncheoul Park, Hak-Kyo Lee, Jong-Eun Park, Donghyun Shin
Climate change increases global temperatures, which is lethal to both livestock and humans. Heat stress is known as one of the various livestock stresses, and dairy cows react sensitively to high-temperature stress. We aimed to better understand the effects of heat stress on the health of dairy cows and observing biological changes. Individual cows were divided into normal (21-22 °C, 50-60% humidity) and high temperature (31-32 °C, 80-95% humidity), respectively, for 7-days. We performed metabolomic and transcriptome analyses of the blood and gut microbiomes of feces...
2024: PloS One
https://read.qxmd.com/read/38525014/influence-of-different-ratios-of-dspe-peg2k-on-ester-prodrug-self-assembly-nanoparticles-for-cell-migration-and-proliferation-suppression
#8
JOURNAL ARTICLE
Huiyun Zhang, Shunru Wei, Yunfei Hu, Yu Zhang, Hao Yao, Gang Qi, Michael Adu-Frimpong, Congyong Sun
BACKGROUND: Bufalin (BFL, an active anti-tumor compound derived from toad venom ) is limited in its application due to high toxicity and rapid metabolism of the cardiotonic steroid. Ester prodrug self-assembly nanoparticles have shown significant improved effects in addressing the above-mentioned issues. METHODS: An ester bond was formed between linoleic acid and bufalin to synthesize linoleic acid-bufalin prodrug (LeB). The self-assembly nanoparticles (LeB-PSNs) containing different mass ratios of DSPE-PEG2k and prodrug (6:4, 7:3, 8:2, 9:1 and 10:0) were prepared via co-precipitation method and defined as 6:4-PSNs, 7:3-PSNs, 8:2-PSNs, 9:1-PSNs and LeB-PSNs, respectively...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38523644/the-anti-cholestatic-effects-of-coptis-chinensis-franch-alone-and-combined-with-tetradium-ruticarpum-a-jussieu-t-g-hartley-dual-effects-on-fecal-metabolism-and-microbial-diversity
#9
JOURNAL ARTICLE
Jun Han, Peijie Wu, Zongying Xu, Chao Liu, Qian Chen, Fenghua Zhang, Huan Tao, Dan Luo, Li Zhou, Bo Wang, Zhe Gao, Tao Shen, Yueqiang Wen, Han Yu
Introduction: Drug dosages and combinations are the main factors that affect the efficacy of pleiotropic traditional Chinese medicine (TCM). Coptis chinensis Franch. (CF) is a representative TCM with multiple effects and is often combined with Tetradium ruticarpum (A. Jussieu) T. G. Hartley (TR) to treat cholestasis. The present study assessed the influence of CF dose and its combination with TR on the efficacy of CF in cholestasis treatment, including their effects on fecal metabolism and fecal microorganisms...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38520147/discovery-of-small-molecule-entry-inhibitors-targeting-the-linoleic-acid-binding-pocket-of-sars-cov-2-spike-protein
#10
JOURNAL ARTICLE
Roshny Prasad, Anil Kadam, Vinitha Vinod Padippurackal, Aparna Pulikuttymadom Balasubramanian, Naveen Kumar Chandrakumaran, Kartik Suresh Rangari, Pawan Dnyaneshwar Khangar, Harikrishnan Ajith, Kathiresan Natarajan, Rajesh Chandramohanadas, Shijulal Nelson-Sathi
Spike glycoprotein has a significant role in the entry of SARS-CoV-2 to host cells, which makes it a potential drug target. Continued accumulation of non-synonymous mutations in the receptor binding domain of spike protein poses great challenges in identifying antiviral drugs targeting this protein. This study aims to identify potential entry inhibitors of SARS-CoV-2 using virtual screening and molecular dynamics (MD) simulations from three distinct chemical libraries including Pandemic Response Box, Drugbank and DrugCentral, comprising 6971 small molecules...
March 23, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38519185/aqueous-enzymatic-extraction-of-macauba-acrocomia-aculeata-pulp-oil-a-green-and-sustainable-approach-for-high-quality-oil-production
#11
JOURNAL ARTICLE
Guilherme Dallarmi Sorita, Simone Palma Favaro, Dasciana de Sousa Rodrigues, Wellington Paula da Silva Junior, Wesley Gabriel de Oliveira Leal, Alan Ambrosi, Marco Di Luccio
Aqueous enzymatic extraction (AEE) of macauba pulp oil (MPO) was performed in this study with five commercial enzymatic pools. The chemical, nutritional, and thermal properties of the oils with high oil efficiency by AEE were evaluated and compared with mechanical pressing (MP) and organic solvent extraction (SE). Among the AEE processes, the pectinase pool (at pH 5.5 and 50 °C) exhibited the highest process efficiency (88.6 %). The oils presented low acidity values (0.4-3.1 %) and low molar absorptivities, indicating minimal oil degradation...
April 2024: Food Research International
https://read.qxmd.com/read/38519173/exploration-of-markers-in-oxidized-rancidity-walnut-kernels-based-on-lipidomics-and-volatolomics
#12
JOURNAL ARTICLE
Jiaying Huo, Wu Peng, Hui Ouyang, Xiaolong Liu, Ping Wang, Xiongwei Yu, Tingting Xie, Shugang Li
Walnut kernels are prone to oxidation and rancidity due to their rich lipid composition, but the existing evaluation indicators are not sensitive enough to promote their industrial development. This study aims to investigate the potential markers in oxidative rancidity walnut kernels using lipidomics and volatolomics. The results showed that the antioxidant capacity of walnut kernels significantly decreased after oxidation, with the decreasing of total phenolic content from 36276.34 mg GAE/kg to 31281...
April 2024: Food Research International
https://read.qxmd.com/read/38518967/elucidating-the-hepatoprotective-mechanisms-of-cholic-acid-against-ccl-4-induced-acute-liver-injury-a-transcriptomic-and-metabolomic-study
#13
JOURNAL ARTICLE
Zhihong Zhang, Yanping Sun, Yuanning Zeng, Na Cui, Biao Li, Wensen Zhang, Haodong Bai, Na Xing, Haixue Kuang, Qiuhong Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Cholic acid (CA) is one of the main active ingredients in Calculus Bovis, a traditional Chinese medicine, which helps to regulate the heart and liver meridians, clearing the heart, opening the mouth, cooling the liver and calming the wind. However, the molecular mechanism of its liver protective effect is still unclear. AIM OF THE STUDY: Growing attention has been directed towards traditional Chinese medicine (TCM), particularly Calculus Bovis, as a potential solution for liver protection...
March 20, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38515683/comparison-of-characteristics-and-antioxidant-activities-of-sesame-protein-hydrolysates-and-their-fractions
#14
JOURNAL ARTICLE
Rodjana Noptana, David Julian McClements, Lynne A McLandsborough, Ekasit Onsaard
Sesame meal is a by-product obtained from oil extraction. We investigated the characteristics and antioxidant activities of a sesame protein hydrolysate (SPH-B), as well as its peptide fractions. Four peptide fractions (F1; >100 kDa, F2; 10-100 kDa, F3; 1-10 kDa, and F4; <1 kDa) of SPH-B were prepared. The characteristics and antioxidant properties of SPH-B and its peptide fractions were evaluated. Sesame protein (SP) contained protein fractions with molecular weights ranging from 10 to 44 kDa, whereas SPH-B had peptide fractions ranging from 8 to 44 kDa...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38513941/environmentally-relevant-exposure-to-cotinine-induces-neurobehavioral-toxicity-in-zebrafish-danio-rerio-a-study-using-neurobehavioral-and-metabolomic-approaches
#15
JOURNAL ARTICLE
Dan Yang, Wenfei Yu, Jiajia Qu, Yuexing Shen, Jingtong Yu, Ruirui Meng, Zhen Tao, Jiangfei Chen, Wei Du, Haitong Zhe Sun, Yunhui Zhang, Yuanchen Chen, Meirong Zhao
As an important psychoactive substance, cotinine is ubiquitous in aquatic environment and poses a threat to aquatic organisms. However, the mechanism of its adverse health impacts remains unclear. We evaluated the effects of cotinine exposure at environmentally relevant concentrations on the development and locomotor behavior of zebrafish (Danio rerio) larvae using neurotransmitters and whole endogenous metabolism. Mild developmental toxicity and significant neurobehavior disorder, such as spontaneous movement (1-1000 μg/L), 48 hpf tactile response (50, 100, and 1000 μg/L), and 144 hpf swimming speed (1, 10, 100, 500, and 1000 μg/L), were observed in zebrafish...
March 19, 2024: Environmental Pollution
https://read.qxmd.com/read/38513517/application-of-benzothiadiazole-to-cabernet-gernischt-grapes-vitis-vinifera-l-for-quality-improvement-effects-on-aroma-metabolism-precursors-and-related-genes-expression
#16
JOURNAL ARTICLE
Jianfeng Wang, Yuqi Han, Faisal Eudes Sam, Qihui Wang, Bo Zhang, Tengzhen Ma, Jixin Li, Lidan Feng, Yumei Jiang
Pre-harvest spraying of benzothiadiazole (BTH) can improve the winemaking properties of grapes, especially their aroma compounds and phenolics. Limited research has explored the molecular mechanisms by which BTH influences the accumulation of grape aroma precursors during early grape development. This study investigated the effects and putative molecular mechanisms of applying 0.37 mM BTH through whole-plant spraying on the accumulation of aroma metabolism precursors and gene expression in Cabernet Gernischt grapes during ripening...
March 16, 2024: Plant Physiology and Biochemistry: PPB
https://read.qxmd.com/read/38507293/the-impact-of-dietary-oregano-essential-oil-supplementation-on-fatty-acid-composition-and-lipid-stability-in-eggs-stored-at-room-temperature
#17
JOURNAL ARTICLE
A M Johnson, J Charre-Perales, A Todd, M Arguelles-Ramos, A A B Ali
1. In many countries, eggs are not refrigerated and must be stored at room temperature. The objective of this study was to explore the effects of dietary oregano oil (275 mg<mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mo>/</mml:mo></mml:mrow></mml:math>kg; ORE) versus an unsupplemented control diet (CON) on laying hens on the shelf life and fatty acid profile of eggs.2. Treatments were randomly distributed into 10 pens containing 27 birds each...
March 20, 2024: British Poultry Science
https://read.qxmd.com/read/38506160/tyrosol-regulates-hepatic-lipid-metabolism-in-high-fat-diet-induced-nafld-mice
#18
JOURNAL ARTICLE
Yu Wang, Jihang Hou, Xiaoping Li, Pan Chen, Fang Chen, Yao Pan, Zeyuan Deng, Jing Li, Rong Liu, Ting Luo
This study aimed to elucidate the effect of tyrosol (TYR) on the amelioration of nonalcoholic fatty liver disease (NAFLD). Male C57BL/6J mice were fed a low-fat diet (LFD), a high-fat diet (HFD), or a HFD supplemented with 0.025% (w/w) TYR (TYR) for 16 weeks. Following a 16-week intervention, the TYR cohort exhibited diminished final body weight and hepatic lipid accumulation, compared to HFD fed mice. Liver metabolomics analysis revealed that TYR increased the hepatic levels of spermidine, taurine, linoleic acid, malic acid and eicosapentaenoic acid (EPA), indicating the beneficial effect of TYR on lipid homeostasis...
March 20, 2024: Food & Function
https://read.qxmd.com/read/38503857/dietary-linoleic-acid-supplementation-protects-against-obesity-induced-microglial-reactivity-in-mice
#19
JOURNAL ARTICLE
Lucas Jantzen, Stéphanie Dumontoy, Bahrie Ramadan, Christophe Houdayer, Emmanuel Haffen, Aziz Hichami, Naim Akhtar Khan, Vincent Van Waes, Lidia Cabeza
We investigated whether linoleic acid (LA) supplementation could modulate emotional behavior and microglia-related neuroinflammation. For that, male mice of C57BL/6J genetic background fed either a high-fat diet (HFD) or a standard diet (STD) for 12 weeks, were treated with a vehicle or LA solution for 5 weeks before being evaluated for emotional behavior using a battery of behavioral tests. The animals were subsequently sacrificed and their brains collected and processed for immunofluorescence staining, targeting microglia-specific calcium-binding proteins (IBA-1)...
March 19, 2024: Scientific Reports
https://read.qxmd.com/read/38503788/evaluation-of-synergistic-antagonistic-antibacterial-activities-of-fatty-oils-from-apricot-date-grape-and-black-seeds
#20
JOURNAL ARTICLE
Farah M Joujou, Nada El Darra, Hiba N Rajha, Elie Salem Sokhn, Nisreen Alwan
The increasing antimicrobial resistance requires continuous investigation of new antimicrobial agents preferably derived from natural sources. New powerful antibacterial agents can be produced by simply combining oils that are known for their antibacterial activities. In this study, apricot seed oil (ASO), date seed oil (DSO), grape seed oil (GSO), and black seed oil (BSO) alone and in binary mixtures were assessed. Fatty acid profiles of individual oils and oil mixtures showed linoleic acid, oleic acid, palmitic acid, stearic acid, and linolenic acid contents...
March 19, 2024: Scientific Reports
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