Dan Yang, Wenfei Yu, Jiajia Qu, Yuexing Shen, Jingtong Yu, Ruirui Meng, Zhen Tao, Jiangfei Chen, Wei Du, Haitong Zhe Sun, Yunhui Zhang, Yuanchen Chen, Meirong Zhao
As an important psychoactive substance, cotinine is ubiquitous in aquatic environment and poses a threat to aquatic organisms. However, the mechanism of its adverse health impacts remains unclear. We evaluated the effects of cotinine exposure at environmentally relevant concentrations on the development and locomotor behavior of zebrafish (Danio rerio) larvae using neurotransmitters and whole endogenous metabolism. Mild developmental toxicity and significant neurobehavior disorder, such as spontaneous movement (1-1000 μg/L), 48 hpf tactile response (50, 100, and 1000 μg/L), and 144 hpf swimming speed (1, 10, 100, 500, and 1000 μg/L), were observed in zebrafish...
March 19, 2024: Environmental Pollution