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https://www.readbyqxmd.com/read/28412905/therapeutic-potential-of-heme-oxygenase-1-carbon-monoxide-system-against-ischemia-reperfusion-injury
#1
Yuanyuan Cheng, Jianhui Rong
BACKGROUND: Ischemia-reperfusion (I/R) injury causes the dysfunctions of different major organs, leading to morbidity and mortality on the global scale. Among a battery of therapeutic targets, the heme oxygenase-1 (HO-1)/carbon monoxide (CO) system has been evaluated for the development of new therapies against I/R injury. The enzyme HO-1 catalyzes the degradation of heme into three biologically active end products, namely biliverdin/bilirubin, CO and ferrous ion. Interestingly, CO is one of a few bioactive gaseous molecules with the capability of regulating inflammation, cell survival and growth...
April 13, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28406796/experimental-dosimetric-comparison-of-1-h-4-he-12-c-and-16-o-scanned-ion-beams
#2
T Tessonnier, A Mairani, S Brons, T Haberer, J Debus, K Parodi
At the Heidelberg Ion Beam Therapy Center, scanned helium and oxygen ion beams are available in addition to the clinically used protons and carbon ions for physical and biological experiments. In this work, a study of the basic dosimetric features of the different ions is performed in the entire therapeutic energy range. Depth dose distributions are investigated for pencil-like beam irradiation, with and without a modulating ripple filter, focusing on the extraction of key Bragg curve parameters, such as the range, the peak-width and the distal 80%-20% fall-off...
April 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28399182/clinical-outcomes-using-carbon-ion-radiotherapy-and-dose-volume-histogram-comparison-between-carbon-ion-radiotherapy-and-photon-therapy-for-t2b-4n0m0-non-small-cell-lung-cancer-a-pilot-study
#3
Katsuyuki Shirai, Motohiro Kawashima, Jun-Ichi Saitoh, Takanori Abe, Kyohei Fukata, Yuka Shigeta, Daisuke Irie, Shintaro Shiba, Naoko Okano, Tatsuya Ohno, Takashi Nakano
The safety and efficacy of carbon-ion radiotherapy for advanced non-small cell lung cancer have not been established. We evaluated the clinical outcomes and dose-volume histogram parameters of carbon-ion radiotherapy compared with photon therapy in T2b-4N0M0 non-small cell lung cancer. Twenty-three patients were treated with carbon-ion radiotherapy between May 2011 and December 2015. Seven, 14, and 2 patients had T2b, T3, and T4, respectively. The median age was 78 (range, 53-91) years, with 22 male patients...
2017: PloS One
https://www.readbyqxmd.com/read/28384125/optimizing-the-modified-microdosimetric-kinetic-model-input-parameters-for-proton-and-sup-4-sup-he-ion-beam-therapy-application
#4
Andrea Mairani, Giuseppe Magro, Thomas Tessonnier, Till Boehlen, Silvia Molinelli, Alfredo Ferrari, Katia Parodi, Juergen Debus, Thomas Haberer
Models able to properly predict relative biological effectiveness (RBE) values are needed for an accurate determination of the biological effect with proton and <sup>4</sup>He ion beams. This is particularly important for including RBE calculations in treatment planning studies comparing biologically optimized proton and <sup>4</sup>He ion plans. In this work, we have tailored the predictions of the modified Microdosimetric Kinetic Model (MKM), which is clinically applied for carbon ion beam therapy in Japan, to reproduce RBE with proton and <sup>4</sup>He ion beams...
April 6, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28370020/development-of-the-open-source-dose-calculation-and-optimization-toolkit-matrad
#5
Hans-Peter Wieser, Eduardo Cisternas, Niklas Wahl, Silke Ulrich, Alexander Stadler, Henning Mescher, Lucas-Raphael Müller, Thomas Klinge, Hubert Gabrys, Lucas Burigo, Mark Bangert, Andrea Mairani, Swantje Ecker, Benjamin Ackermann, Malte Ellerbrock, Katia Parodi, Oliver Jäkel
PURPOSE: We report on the development of the open-source cross-platform radiation treatment planning toolkit matRad and its comparison against validated treatment planning systems. The toolkit enables three-dimensional intensity-modulated radiation therapy treatment planning for photons, scanned protons and scanned carbon ions. METHODS: matRad is entirely written in Matlab and is freely available online. It re-implements well-established algorithms employing a modular and sequential software design to model the entire treatment planning workflow...
April 1, 2017: Medical Physics
https://www.readbyqxmd.com/read/28350950/spine-oncology-metastatic-spine-tumors
#6
David Choi, Mark Bilsky, Michael Fehlings, Charles Fisher, Ziya Gokaslan
Surgery for spinal metastases remains the mainstay treatment for pain, instability, and neurological deterioration due to tumor infiltration of the spine. However, several new therapies are emerging which may improve outcomes further, and in some cases even replace the need for surgery. We now have a better understanding of which factors influence survival and quality of life after surgery, and this underpins the development and application of new treatments, and assessment of outcome.Depending on genetic subtyping of tumors, novel immunotherapies and chemotherapies may be very effective in prolonging quality of life...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28348976/combination-of-photon-and-carbon-ion-irradiation-with-targeted-therapy-substances-temsirolimus-and-gemcitabine-in-hepatocellular-carcinoma-cell-lines
#7
Sarah Dehne, Clarissa Fritz, Stefan Rieken, Daniela Baris, Stephan Brons, Thomas Haberer, Jürgen Debus, Klaus-Josef Weber, Thomas E Schmid, Stephanie E Combs, Daniel Habermehl
BACKGROUND: This work investigates on putative cytotoxic effects in four different hepatocellular carcinoma (HCC) cell lines after irradiation with photons or carbon ions in combination with new targeted molecular therapy using either Temsirolimus (TEM) or Gemcitabine (GEM). METHODS AND MATERIALS: The HCC cell lines HepG2, Hep3B, HuH7, and PLC were cultured and irradiated with photons or carbon ions at the Heidelberg Ion Beam Therapy Center using the raster-scanning method...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28344441/successful-treatment-of-periodic-paralysis-with-coenzyme-q10-two-case-reports
#8
Yuwei Da, Lin Lei, Karin Jurkat-Rott, Frank Lehmann-Horn
Primary periodic paralyses (PPs) are autosomal dominant ion channel disorders characterized by episodic flaccid weakness associated with variations in serum potassium level. The main prophylactic therapy of choice for PPsis carbonic anhydrase inhibitors that are not always effective. In this report, we described two PP patients who were successfully treated with coenzyme Q10. They remained asymptomatic since initiation of treatment, which may be associated with promotion of energy synthesis, anti-oxidant activity, influence of the fiber type composition and regulation of the expression of gene...
October 2016: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
https://www.readbyqxmd.com/read/28342377/live-cell-biosensing-platforms-using-graphene-based-hybrid-nanomaterials
#9
REVIEW
Tae-Hyung Kim, Donghyun Lee, Jeong-Woo Choi
A novel strategy to precisely detect or monitor various biomaterials in living cells poses paramount importance in understanding cellular processes. Graphene, a newly emerged two-dimensional carbon material, has been widely utilized for biosensors owing to its multifarious characteristics including mechanical, electrical, and optical properties (e.g. stability, conductivity, fluorescence quenching and photoluminescence). In addition, graphene derivatives and their innate characteristics, such as biocompatibility low cytotoxicity and water solubility have facilitated the use of graphene-based materials for live cell biosensing, wherein graphene is utilized as a core material by itself or in combination with other functional nanomaterials to load target-specific probes, fluorescent dyes, and other signaling molecules...
March 18, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28339788/intravenous-dendritic-cell-administration-enhances-suppression-of-lung-metastasis-induced-by-carbon-ion-irradiation
#10
Ken Ando, Hidetoshi Fujita, Akihiro Hosoi, Liqiu Ma, Masaru Wakatsuki, Ken-Ichiro Seino, Kazuhiro Kakimi, Takashi Imai, Takashi Shimokawa, Takashi Nakano
Carbon-ion radiotherapy (CIRT) is an advanced radiotherapy and has achieved good local control, even in tumors that are resistant to conventional photon beam radiotherapy (PBRT). However, distant metastasis control is an important issue. Recently, the combination of radiotherapy and immunotherapy has attracted the attention. In immunotherapy, dendritic cells (DCs) play a pivotal role in the anti-tumor immune system. However, the mechanisms underlying the combination therapy of DCs and radiotherapy have been unclear...
February 27, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28339740/margin-estimation-and-disturbances-of-irradiation-field-in-layer-stacking-carbon-ion-beams-for-respiratory-moving-targets
#11
Shinya Tajiri, Mutsumi Tashiro, Tomohiro Mizukami, Chihiro Tsukishima, Masami Torikoshi, Tatsuaki Kanai
Carbon-ion therapy by layer-stacking irradiation for static targets has been practised in clinical treatments. In order to apply this technique to a moving target, disturbances of carbon-ion dose distributions due to respiratory motion have been studied based on the measurement using a respiratory motion phantom, and the margin estimation given by the square root of the summation Internal margin2+Setup margin2 has been assessed. We assessed the volume in which the variation in the ratio of the dose for a target moving due to respiration relative to the dose for a static target was within 5%...
February 23, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28333688/treatment-planning-of-intensity-modulated-composite-particle-therapy-with-dose-and-linear-energy-transfer-optimization
#12
Taku Inaniwa, Nobuyuki Kanematsu, Koji Noda, Tadashi Kamada
The biological effect of charged-particle beams depends on both dose and radiation quality. The radiation quality of charged-particle beams has been most commonly represented by the linear energy transfer (LET) in radiation biology studies. We investigated a new therapeutic technique using two or more ion species in one treatment session, which we call an Intensity Modulated composite PArtiCle Therapy (IMPACT), for optimizing the physical dose and dose-averaged LET distributions in a patient as its proof of principle...
March 23, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28332989/multicenter-study-of-carbon-ion-radiation-therapy-for-mucosal-melanoma-of-the-head-and-neck-subanalysis-of-the-japan-carbon-ion-radiation-oncology-study-group-j-cros-study-1402-hn
#13
Masashi Koto, Yusuke Demizu, Jun-Ichi Saitoh, Hiroaki Suefuji, Hiroshi Tsuji, Tomoaki Okimoto, Tatsuya Ohno, Yoshiyuki Shioyama, Ryo Takagi, Kenji Nemoto, Takashi Nakano, Tadashi Kamada
PURPOSE: To evaluate the efficacy and safety of carbon-ion radiation therapy (RT) for mucosal melanoma of the head and neck (MMHN) in the Japan Carbon-Ion Radiation Oncology Study Group study. METHODS AND MATERIALS: Patients with MMHN with N0-1M0 status who were treated with carbon-ion RT at 4 institutions in Japan between November 2003 and December 2014 were analyzed retrospectively. Two hundred sixty patients (male, 111; female, 149; median age, 68 years) with histologically proven MMHN were enrolled...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28302921/deciphering-the-acute-cellular-phosphoproteome-response-to-irradiation-with-x-rays-protons-and-carbon-ions
#14
Martin Winter, Ivana Dokic, Julian Schlegel, Uwe Warnken, Jürgen Debus, Amir Abdollahi, Martina Schnölzer
Radiotherapy is a cornerstone of cancer therapy. The recently established particle therapy with raster-scanning protons and carbon ions landmarks a new era in the field of high-precision cancer medicine. However, molecular mechanisms governing radiation induced intracellular signaling remain elusive. Here, we present the first comprehensive proteomic and phosphoproteomic study applying stable isotope labeling by amino acids in cell culture (SILAC) in combination with high-resolution mass spectrometry to decipher cellular response to irradiation with X-rays, protons and carbon ions...
March 16, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28275377/impact-of-particle-irradiation-on-the-immune-system-from-the-clinic-to-mars
#15
REVIEW
Rodrigo Fernandez-Gonzalo, Sarah Baatout, Marjan Moreels
Despite the generalized use of photon-based radiation (i.e., gamma rays and X-rays) to treat different cancer types, particle radiotherapy (i.e., protons and carbon ions) is becoming a popular, and more effective tool to treat specific tumors due to the improved physical properties and biological effectiveness. Current scientific evidence indicates that conventional radiation therapy affects the tumor immunological profile in a particular manner, which in turn, might induce beneficial effects both at local and systemic (i...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28252446/the-fluka-monte-carlo-code-coupled-with-the-nirs-approach-for-clinical-dose-calculations-in-carbon-ion-therapy
#16
Giuseppe Magro, Tordis Dahle, Silvia Molinelli, Mario Ciocca, Piero Fossati, Alfredo Ferrari, Taku Inaniwa, Naruhiro Matsufuji, Kristian Ytre-Hauge, Andrea Mairani
Particle therapy facilities often require Monte Carlo (MC) simulations to overcome intrinsic limitations of analytical treatment planning systems (TPS) related to the description of the mixed radiation field and beam interaction with tissue inhomogeneities. Some of these uncertainties may affect the computation of effective dose distributions; therefore, particle therapy dedicated MC codes should provide both absorbed and biological doses. Two biophysical models are currently applied clinically in particle therapy: the Local Effect Model (LEM) and the Microdosimetric Kinetic Model (MKM)...
March 2, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28252445/comparing-the-dosimetric-impact-of-interfractional-anatomical-changes-in-photon-proton-and-carbon-ion-radiotherapy-for-pancreatic-cancer-patients
#17
Antonetta C Houweling, Koen Crama, Jorrit Visser, Kyohei Fukata, Coen R N Rasch, Tatsuya Ohno, Arjan Bel, Astrid van der Horst
Radiotherapy using charged particles is characterized by a low dose to the surrounding healthy organs, while delivering a high dose to the tumor. However, interfractional anatomical changes can greatly affect the robustness of particle therapy. Therefore, we compared the dosimetric impact of interfractional anatomical changes (i.e. body contour differences and gastrointestinal gas volume changes) in photon, proton and carbon ion therapy for pancreatic cancer patients. In this retrospective planning study, photon, proton and carbon ion treatment plans were created for 9 patients...
April 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28236644/theoretical-dosimetric-evaluation-of-carbon-and-oxygen-minibeam-radiation-therapy
#18
Wilfredo González, Cécile Peucelle, Yolanda Prezado
PURPOSE: Charged particles have several advantages over x-ray radiations, both in terms of physics and radiobiology. The combination of these advantages with those of minibeam radiation therapy (MBRT) could help enhancing the therapeutic index for some cancers with poor prognosis. Among the different ions explored for therapy, carbon ions are considered to provide the optimum physical and biological characteristics. Oxygen could be advantageous due to a reduced oxygen enhancement ratio along with a still moderate biological entrance dose...
February 25, 2017: Medical Physics
https://www.readbyqxmd.com/read/28218247/laser-driven-ion-acceleration-from-plasma-micro-channel-targets
#19
D B Zou, A Pukhov, L Q Yi, H B Zhou, T P Yu, Y Yin, F Q Shao
Efficient energy boost of the laser-accelerated ions is critical for their applications in biomedical and hadron research. Achiev-able energies continue to rise, with currently highest energies, allowing access to medical therapy energy windows. Here, a new regime of simultaneous acceleration of ~100 MeV protons and multi-100 MeV carbon-ions from plasma micro-channel targets is proposed by using a ~10(20) W/cm(2) modest intensity laser pulse. It is found that two trains of overdense electron bunches are dragged out from the micro-channel and effectively accelerated by the longitudinal electric-field excited in the plasma channel...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28190704/high-risk-prostate-cancer-and-radiotherapy-the-past-and-the-future-a-benchmark-for-a-new-mixed-beam-radiotherapy-approach
#20
Giulia Marvaso, Barbara A Jereczek-Fossa, Giulia Riva, Camilla Bassi, Cristiana Fodor, Delia Ciardo, Raffaella Cambria, Floriana Pansini, Dario Zerini, Paolo De Marco, Federica Cattani, Ottavio De Cobelli, Roberto Orecchia
BACKGROUND: The prognosis for patients with high-risk prostate cancer is poor. No consensus exists on the most effective treatment. The aim of this retrospective study was to identify the biochemical progression-free survival and the toxicity profile of patients with localized high-risk prostate cancer treated with external beam radiation therapy. These results will constitute a benchmark for a prospective "mixed beam" trial: a boost with carbon ions followed by a pelvic photon intensity-modulated radiotherapy (NCT02672449 [clinicaltrials...
January 18, 2017: Clinical Genitourinary Cancer
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