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https://www.readbyqxmd.com/read/28730646/prospective-observational-study-of-carbon-ion-radiotherapy-for-non-squamous-cell-carcinoma-of-the-head-and-neck
#1
Katsuyuki Shirai, Jun-Ichi Saitoh, Atsushi Musha, Takanori Abe, Daijiro Kobayashi, Takeo Takahashi, Tomoaki Tamaki, Hidemasa Kawamura, Yukihiro Takayasu, Masato Shino, Minoru Toyoda, Katsumasa Takahashi, Junko Hirato, Satoshi Yokoo, Kazuaki Chikamatsu, Tatsuya Ohno, Takashi Nakano
To evaluate the efficacy and safety of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck. Thirty-five patients were enrolled in this prospective study. The primary endpoint was the 3-year local control rate, while secondary endpoints included the 3-year overall survival rate and adverse events. Acute and late adverse events were evaluated according to the Common Terminology Criteria for Adverse Events, version 4.0. The median follow-up time for all patients was 39 months. Thirty-two and 3 patients received 64...
July 21, 2017: Cancer Science
https://www.readbyqxmd.com/read/28727901/carbon-ion-radiotherapy-for-isolated-para-aortic-lymph-node-recurrence-from-colorectal-cancer
#2
Yuka Isozaki, Shigeru Yamada, Shohei Kawashiro, Shigeo Yasuda, Naomi Okada, Daniel Ebner, Hiroshi Tsuji, Tadashi Kamada, Hisahiro Matsubara
BACKGROUND: The safety and effectiveness of carbon-ion radiotherapy (CIRT) for isolated para-aortic lymph node (PALN) metastasis was evaluated retrospectively. METHODS: CIRT for isolated PALN metastasis from CRC was performed in 34 cases from June 2006 to August 2015 in our institute. A median dose of 52.8 Gy(RBE) (range, 48-52.8 Gy(RBE)) was delivered with a median daily dose of 4.4 Gy(RBE) (range, 4.0-4.4 Gy(RBE)). RESULTS: The median follow-up duration for all patients was 24...
July 20, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28718770/benchmarking-gate-geant4-for-sup-16-sup-o-ion-beam-therapy
#3
Andreas Franz Resch, Hermann Fuchs, Dietmar Georg
Oxygen (<sup>16</sup>O) ions are a potential alternative to carbon ions in ion beam therapy. Their enhanced linear energy transfer indicates a higher relative biological effectiveness and a reduced oxygen enhancement ratio. Due to the limited availability of <sup>16</sup>O ion beams, Monte Carlo (MC) transport codes are important research tools to investigate their potential. The purpose of this study was to validate GATE/Geant4 for <sup>16</sup>O ion beam therapy on experimental data from literature...
July 18, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28703340/core-satellite-polydopamine-gadolinium-metallofullerene-nanotheranostics-for-multimodal-imaging-guided-combination-cancer-therapy
#4
Sheng Wang, Jing Lin, Zhantong Wang, Zijian Zhou, Ruiliang Bai, Nan Lu, Yijing Liu, Xiao Fu, Orit Jacobson, Wenpei Fan, Junle Qu, Siping Chen, Tianfu Wang, Peng Huang, Xiaoyuan Chen
Integration of magnetic resonance imaging (MRI) and other imaging modalities is promising to furnish complementary information for accurate cancer diagnosis and imaging-guided therapy. However, most gadolinium (Gd)-chelator MR contrast agents are limited by their relatively low relaxivity and high risk of released-Gd-ions-associated toxicity. Herein, a radionuclide-(64) Cu-labeled doxorubicin-loaded polydopamine (PDA)-gadolinium-metallofullerene core-satellite nanotheranostic agent (denoted as CDPGM) is developed for MR/photoacoustic (PA)/positron emission tomography (PET) multimodal imaging-guided combination cancer therapy...
July 13, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28661074/a-review-of-recent-developments-of-mesoporous-materials
#5
REVIEW
Steven L Suib
This personal account concerns novel recent discoveries in the area of mesoporous materials. Most of the papers discussed have been published within the last two to three years. A major emphasis of most of these papers is the synthesis of unique mesoporous materials by a variety of synthetic methods. Many of these articles focus on the control of the pore sizes and shapes of mesoporous materials. Synthetic methods of various types have been used for such control of porosity including soft templating, hard templating, nano-casting, electrochemical methods, surface functionalization, and trapping of species in pores...
June 29, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28650846/dosimetric-verification-in-water-of-a-monte-carlo-treatment-planning-tool-for-proton-helium-carbon-and-oxygen-ion-beams-at-the-heidelberg-ion-beam-therapy-center
#6
Thomas Tessonnier, Till Tobias Boehlen, Francesco Cerutti, Alfredo Ferrari, Paola Roberta Sala, Stephan Brons, Thomas Haberer, Juergen Debus, Katia Parodi, Andrea Mairani
The introduction of "new" ion species in particle therapy needs to be supported by a thorough assessment of their dosimetric properties and by treatment planning comparisons with clinically used proton and carbon ion beams. In addition to the latter two ions, helium and oxygen ion beams are foreseen at the Heidelberg Ion beam Therapy (HIT) center as potential assets for improving clinical outcomes in the near future. We present in this study a dosimetric validation of a FLUKA-based Monte Carlo Treatment Planning tool (MCTP) for protons, helium, carbon and oxygen ions for spread-out Bragg peaks...
June 26, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28623674/cathepsin-k-in-lymphangioleiomyomatosis-lam-cell-fibroblast-interactions-enhance-protease-activity-by-extracellular-acidification
#7
Arundhati Dongre, Debbie Clements, Andrew J Fisher, Simon R Johnson
Lymphangioleiomyomatosis (LAM) is a rare disease in which clonal LAM cells infiltrate the lungs and lymphatics. In association with recruited fibroblasts, LAM cells form nodules adjacent to lung cysts. It is hypothesized that LAM nodule-derived proteases lead to cyst formation. On protease gene-expression profiling in whole-lung tissue, cathepsin K was 40-fold overexpressed in LAM compared with control lungs (P ≤ 0.0001). Immunohistochemistry confirmed cathepsin K protein in LAM nodules but not in control lungs...
June 14, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28599495/investigation-of-the-relative-biological-effectiveness-and-uniform-isobiological-killing-effects-of-irradiation-with-a-clinical-carbon-sobp-beam-on-dna-repair-deficient-cho-cells
#8
Shigeaki Sunada, Ian M Cartwright, Hirokazu Hirakawa, Akira Fujimori, Mitsuru Uesaka, Takamitsu A Kato
Spread-out Bragg peak (SOBP) C ions have been used clinically in charged particle radiation therapy for years. An SOBP beam consists of various monoenergetic Bragg peaks; however, the biological effect of irradiation with an SOBP beam track has not been well-studied. In order to determine the clinically prospective molecular targets, radiosensitivity to the beam track in DNA repair deficient cell lines was investigated. A total of four distinct Chinese hamster ovary (CHO) cell lines, including CHO10B2 (wild-type), V3 (protein kinase DNA-activated catalytic polypeptide deficient), 51D1 (RAD51 paralog D deficient) and PADR9 [poly(ADP-ribose) polymerase (PARP) deficient], were irradiated with gamma-rays, C ions (290 MeV/n) and Fe ions (500 MeV/n), in order to compare cellular lethality...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28595643/planning-strategies-for-inter-fractional-robustness-in-pancreatic-patients-treated-with-scanned-carbon-therapy
#9
Vania Batista, Daniel Richter, Stephanie E Combs, Oliver Jäkel
BACKGROUND: Managing inter-fractional anatomy changes is a challenging task in radiotherapy of pancreatic tumors, especially in scanned carbon-ion delivery. This treatment planning study aims to focus on clinically feasible solutions, such as the beam angle selection and margin design to increase the robustness against inter-fractional uncertainties. METHODS: This study included 10 patients with weekly 3D-CT imaging and physician-approved Clinical Target Volume (CTV)...
June 8, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28587003/photon-volumetric-modulated-arc-therapy-versus-intensity-modulated-proton-therapy-versus-intensity-modulated-carbon-ion-therapy-in-the-delivery-of-hypofractionated-thoracic-radiation-therapy
#10
A Chi, L C Lin, S Wen, H Yan, W C Hsi
No abstract text is available yet for this article.
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28586136/benchmarking-geant4-hadronic-models-for-prompt-%C3%AE-monitoring-in-carbon-ion-therapy
#11
Marie Vanstalle, Christian Finck, Ilaria Mattei, Alessio Sarti, Erika De Lucia, Luca Piersanti, Fabio Bellini, Francesco Collamati, Riccardo Faccini, Fernando Ferroni, Vincenzo Patera, Adalberto Sciubba, Giacomo Traini, Cecilia Voena, Fabiano Bini, Marco Durante, Marta Rovitus, Christoph Schuy, Salvatore Fiore, Michela Marafini, Chiara La Tessa
PURPOSE: The real-time monitoring of the spread-out Bragg peak would allow the planned dose delivered during treatment to be directly verified, but this poses a major challenge in modern ion beam therapy. A possible method to achieve this goal is to exploit the production of secondary particles by the nuclear reactions of the beam with the patient and correlate their emission profile to the planned target volume position. In this study, we present both the production rate and energy spectra of the prompt-γ produced by the interactions of the (12) C ion beam with a polymethyl methacrylate (PMMA) target...
June 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/28576582/visualization-of-air-and-metal-inhomogeneities-in-phantoms-irradiated-by-carbon-ion-beams-using-prompt-secondary-ions
#12
T Gaa, M Reinhart, B Hartmann, J Jakubek, P Soukup, O Jäkel, M Martišíková
PURPOSE: Non-invasive methods for monitoring of the therapeutic ion beam extension in the patient are desired in order to handle deteriorations of the dose distribution related to changes of the patient geometry. In carbon ion radiotherapy, secondary light ions represent one of potential sources of information about the dose distribution in the irradiated target. The capability to detect range-changing inhomogeneities inside of an otherwise homogeneous phantom, based on single track measurements, is addressed in this paper...
May 30, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28561011/rapid-implementation-of-the-repair-misrepair-fixation-rmf-model-facilitating-online-adaption-of-radiosensitivity-parameters-in-ion-therapy
#13
F Kamp, D J Carlson, J J Wilkens
INTRODUCTION: Treatment planning for ion therapy must account for physical properties of the beam as well as differences in the relative biological effectiveness (RBE) of ions compared to photons. In this work, we present a fast RBE calculation approach, based on the decoupling of physical properties and the [Formula: see text] ratio commonly used to describe the radiosensitivity of irradiated cells or organs. MATERIAL AND METHODS: In the framework of the mechanistic repair-misrepair-fixation (RMF) model, the biological modeling can be decoupled from the physical dose...
July 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28556241/carbon-and-oxygen-minibeam-radiation-therapy-an-experimental-dosimetric-evaluation
#14
Immaculada Martínez-Rovira, Wilfredo González, Stephan Brons, Yolanda Prezado
PURPOSE: To perform dosimetric characterization of a minibeam collimator in both carbon and oxygen ion beams to guide optimal set up geometry and irradiation for future radiobiological studies using these beams. METHODS: Carbon and oxygen minibeams were generated using a prototype tungsten multislit collimator presenting line apertures 700 μm wide, which are spaced 3500 μm centre-to-centre distance apart. Several radiation beam spots generated the desired field size of 15X15 mm(2) and production of a 50 mm long spread out Bragg peak (SOBP) centered at 80 mm-depth in water...
May 29, 2017: Medical Physics
https://www.readbyqxmd.com/read/28540940/modelling-charge-transfer-processes-in-c-2-tetrahydrofuran-collision-for-ion-induced-radiation-damage-in-dna-building-blocks
#15
Ewa Erdmann, Marie-Christine Bacchus-Montabonel, Marta Łabuda
Investigations of collision-induced processes involving carbon ions and molecules of biological interest, in particular DNA building blocks, are crucial to model the effect of radiation on cells in order to improve medical treatments for cancer therapy. Using carbon ions appears to be one of the most efficient ways to increase biological effectiveness to damage cancerous cells by irradiating deep-seated tumors. Therefore, interest in accurate calculations to understand fundamental processes occurring in ion-molecule collision systems has been growing recently...
May 25, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28535963/usefulness-of-11-c-methionine-pet-for-predicting-the-efficacy-of-carbon-ion-radiation-therapy-for-head-and-neck-mucosal-malignant-melanoma
#16
M Hasebe, K Yoshikawa, R Nishii, K Kawaguchi, T Kamada, Y Hamada
The aim of this study was to determine whether l-methyl-[(11)C]-methionine (MET) positron emission tomography (PET) allows the prediction of outcomes in patients with head and neck mucosal malignant melanoma treated with carbon ion radiation therapy (CIRT). This was a retrospective cohort study involving 85 patients who underwent a MET-PET or MET-PET/computed tomography (CT) examination before and after CIRT. MET uptake in the tumour was evaluated semi-quantitatively using the tumour-to-normal tissue ratio (TNR)...
May 20, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28474791/multi-institutional-retrospective-study-of-mucoepidermoid-carcinoma-treated-with-carbon-ion-radiotherapy
#17
Katsuyuki Shirai, Masashi Koto, Yusuke Demizu, Hiroaki Suefuji, Tatsuya Ohno, Hiroshi Tsuji, Tomoaki Okimoto, Yoshiyuki Shioyama, Jun-Ichi Saitoh, Kenji Nemoto, Takashi Nakano, Tadashi Kamada
This study aimed to evaluate the clinical outcomes of patients with mucoepidermoid carcinomas in the head and neck treated with carbon-ion radiotherapy. Data from 26 patients who underwent carbon-ion radiotherapy in four facilities were analyzed in this multi-institutional retrospective study: the Japan Carbon-ion Radiation Oncology Study Group. The median follow-up time was 34 months. One patient experienced local recurrence, and the 3-year local control rate was 95%. One patient developed lymph node recurrence and five developed distant metastases...
July 2017: Cancer Science
https://www.readbyqxmd.com/read/28463156/particle-therapy-using-protons-or-carbon-ions-for-unresectable-or-incompletely-resected-bone-and-soft-tissue-sarcomas-of-the-pelvis
#18
Yusuke Demizu, Dongcun Jin, Nor Shazrina Sulaiman, Fumiko Nagano, Kazuki Terashima, Sunao Tokumaru, Takashi Akagi, Osamu Fujii, Takashi Daimon, Ryohei Sasaki, Nobukazu Fuwa, Tomoaki Okimoto
PURPOSE: To retrospectively analyze the treatment outcomes of particle therapy using protons or carbon ions for unresectable or incompletely resected bone and soft tissue sarcomas (BSTSs) of the pelvis. METHODS AND MATERIALS: From May 2005 to December 2014, 91 patients with nonmetastatic histologically proven unresectable or incompletely resected pelvic BSTSs underwent particle therapy with curative intent. The particle therapy used protons (52 patients) or carbon ions (39 patients)...
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28412905/therapeutic-potential-of-heme-oxygenase-1-carbon-monoxide-system-against-ischemia-reperfusion-injury
#19
Yuanyuan Cheng, Jianhui Rong
BACKGROUND: Ischemia-reperfusion (I/R) injury causes the dysfunctions of different major organs, leading to morbidity and mortality on the global scale. Among a battery of therapeutic targets, the heme oxygenase-1 (HO-1)/carbon monoxide (CO) system has been evaluated for the development of new therapies against I/R injury. The enzyme HO-1 catalyzes the degradation of heme into three biologically active end products, namely biliverdin/bilirubin, CO and ferrous ion. Interestingly, CO is one of a few bioactive gaseous molecules with the capability of regulating inflammation, cell survival and growth...
April 13, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28406796/experimental-dosimetric-comparison-of-1-h-4-he-12-c-and-16-o-scanned-ion-beams
#20
T Tessonnier, A Mairani, S Brons, T Haberer, J Debus, K Parodi
At the Heidelberg Ion Beam Therapy Center, scanned helium and oxygen ion beams are available in addition to the clinically used protons and carbon ions for physical and biological experiments. In this work, a study of the basic dosimetric features of the different ions is performed in the entire therapeutic energy range. Depth dose distributions are investigated for pencil-like beam irradiation, with and without a modulating ripple filter, focusing on the extraction of key Bragg curve parameters, such as the range, the peak-width and the distal 80%-20% fall-off...
May 21, 2017: Physics in Medicine and Biology
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