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Carbon ion therapy

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https://www.readbyqxmd.com/read/28190704/high-risk-prostate-cancer-and-radiotherapy-the-past-and-the-future-a-benchmark-for-a-new-mixed-beam-radiotherapy-approach
#1
Giulia Marvaso, Barbara A Jereczek-Fossa, Giulia Riva, Camilla Bassi, Cristiana Fodor, Delia Ciardo, Raffaella Cambria, Floriana Pansini, Dario Zerini, Paolo De Marco, Federica Cattani, Ottavio De Cobelli, Roberto Orecchia
BACKGROUND: The prognosis for patients with high-risk prostate cancer is poor. No consensus exists on the most effective treatment. The aim of this retrospective study was to identify the biochemical progression-free survival and the toxicity profile of patients with localized high-risk prostate cancer treated with external beam radiation therapy. These results will constitute a benchmark for a prospective "mixed beam" trial: a boost with carbon ions followed by a pelvic photon intensity-modulated radiotherapy (NCT02672449 [clinicaltrials...
January 18, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28183656/facile-synthesis-of-carbon-dot-and-residual-carbon-nanobeads-implications-for-ion-sensing-medicinal-and-biological-applications
#2
Rohit Ranganathan Gaddam, Sudip Mukherjee, Neelambaram Punugupati, D Vasudevan, Chitta Ranjan Patra, Ramanuj Narayan, Raju Vsn Kothapalli
Synthesis of carbon dots (Cdots) via chemical route involves disintegration of carbon materials into nano-domains, wherein, after extraction of Cdots, the remaining carbon material is discarded. The present work focuses on studying even the leftover carbon residue namely, carbon nanobeads (CNBs) as an equally important material for applications on par with that of carbon dot. It employs oxidative treatment of carbonised gum olibanum resin (GOR) to produce the carbons namely Cdots and CNBs (as the residue). The Cdots (~5-10nm) exhibit blue-green fluorescence with an optical absorption at ~300nm unlike the CNBs (40-50nm) which fail to exhibit fluorescence...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28152251/diffusion-weighted-mri-treatment-monitoring-of-primary-hypofractionated-proton-and-carbon-ion-prostate-cancer-irradiation-using-raster-scan-technique
#3
Maya B Wolf, Christopher Edler, Diana Tichy, Matthias C Röthke, Heinz-Peter Schlemmer, Klaus Herfarth, David Bonekamp
PURPOSE: To investigate parametric changes in the apparent diffusion coefficient (ADC) at multiple timepoints during and after completion of primary proton and carbon ion irradiation of prostate cancer (PCa) as compared with normal-appearing prostate parenchyma. MATERIALS AND METHODS: In all, 92 patients with histologically confirmed PCa received either proton or carbon ion hypofractionated radiotherapy (RT). All were prospectively evaluated with diffusion-weighted magnetic resonance imaging (DWI-MRI) at five timepoints: baseline, day 10 during therapy and 6 weeks, 6 months, and 18 months after treatment...
February 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28151733/correction-factors-to-convert-microdosimetry-measurements-in-silicon-to-tissue-in-12-c-ion-therapy
#4
David Bolst, Susanna Guatelli, Linh T Tran, Lachlan Chartier, Michael L F Lerch, Naruhiro Matsufuji, Anatoly B Rosenfeld
Silicon microdosimetry is a promising technology for heavy ion therapy (HIT) quality assurance, because of its sub-mm spatial resolution and capability to determine radiation effects at a cellular level in a mixed radiation field. A drawback of silicon is not being tissue-equivalent, thus the need to convert the detector response obtained in silicon to tissue. This paper presents a method for converting silicon microdosimetric spectra to tissue for a therapeutic (12)C beam, based on Monte Carlo simulations...
February 2, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28147655/monte-carlo-simulation-of-photon-emission-below-a-few-hundred-kiloelectronvolts-for-beam-monitoring-in-carbon-ion-therapy
#5
Mitsutaka Yamaguchi, Yuto Nagao, Takahiro Satoh, Hiroyuki Sugai, Makoto Sakai, Kazuo Arakawa, Naoki Kawachi
The purpose of this study is to determine whether the main component of the low-energy (63-68 keV) particles emitted perpendicularly to the (12)C beam from the (12)C-irradiated region in a water phantom is secondary electron bremsstrahlung (SEB). Monte Carlo simulations of a (12)C-beam (290 MeV/u) irradiated on a water phantom were performed. A detector was placed beside the water phantom with a lead collimator between the phantom and the detector. To move the Bragg-peak position, a binary filter was placed in an upper stream of the phantom...
January 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28140352/initial-development-of-gocmc-a-gpu-oriented-fast-cross-platform-monte-carlo-engine-for-carbon-ion-therapy
#6
Nan Qin, Marco Pinto, Zhen Tian, Georgios Dedes, Arnold Pompos, Steve Jiang, Katia Parodi, Xun Jia
Monte Carlo (MC) simulation is considered as the most accurate method for calculation of absorbed dose and fundamental physics quantities related to biological effects in carbon ion therapy. To improve its computational efficiency, we have developed a GPU-oriented fast MC package named goCMC, for carbon therapy. goCMC simulates particle transport in voxelized geometry with kinetic energy up to 450 MeV/u. Class II condensed history simulation scheme with a continuous slowing down approximation was employed. Energy straggling and multiple scattering were modeled...
January 31, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28133027/-an-85-year-old-man-with-lymph-node-metastasis-of-recurrent-rectal-cancer-treated-usingproton-beam-therapy
#7
Kohei Murata, Tomohiro Kitahara, Yoichiro Nushijima, Shu Okamura, Takayuki Minoji, Rie Hamano, Nariaki Fukuchi, Chikara Ebisui, Tetsu Yanagisawa, Hideoki Yokouchi, Masakatsu Kinuta, Yusuke Demizu, Tomoaki Okimoto
There are few reports that describe the efficacy of proton beam therapy for lymph node metastasis of recurrent rectal cancer, and carbon ion radiotherapy yields higher local tumor control rates. Proton beam therapy needs a longer treatment period but is less toxic to adjacent healthy organs compared to carbon ion radiotherapy. Here we report an 85-year-old man who underwent curative surgery for rectal and sigmoid cancer at the age of 76 years. After 4 years and 2 months, he had liver metastases at S3 and S8, both of which were resected...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28114112/secondary-radiation-measurements-for-particle-therapy-applications-prompt-photons-produced-by-4-he-12-c-and-16-o-ion-beams-in-a-pmma-target
#8
I Mattei, F Bini, F Collamati, E De Lucia, P M Frallicciardi, E Iarocci, C Mancini-Terracciano, M Marafini, S Muraro, R Paramatti, V Patera, L Piersanti, D Pinci, A Rucinski, A Russomando, A Sarti, A Sciubba, E Solfaroli Camillocci, M Toppi, G Traini, C Voena, G Battistoni
Charged particle beams are used in particle therapy (PT) to treat oncological patients due to their selective dose deposition in tissues with respect to the photons and electrons used in conventional radiotherapy. Heavy (Z  >  1) PT beams can additionally be exploited for their high biological effectiveness in killing cancer cells. Nowadays, protons and carbon ions are used in PT clinical routines. Recently, interest in the potential application of helium and oxygen beams has been growing. With respect to protons, such beams are characterized by their reduced multiple scattering inside the body, increased linear energy transfer, relative biological effectiveness and oxygen enhancement ratio...
February 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28111101/design-of-a-new-tracking-device-for-on-line-beam-range-monitor-in-carbon-therapy
#9
Giacomo Traini, Giuseppe Battistoni, Angela Bollella, Francesco Collamati, Erika De Lucia, Riccardo Faccini, Fernando Ferroni, Paola Maria Frallicciardi, Carlo Mancini-Terracciano, Michela Marafini, Ilaria Mattei, Federico Miraglia, Silvia Muraro, Riccardo Paramatti, Luca Piersanti, Davide Pinci, Antoni Rucinski, Andrea Russomando, Alessio Sarti, Adalberto Sciubba, Martina Senzacqua, Elena Solfaroli-Camillocci, Marco Toppi, Cecilia Voena, Vincenzo Patera
Charged particle therapy is a technique for cancer treatment that exploits hadron beams, mostly protons and carbon ions. A critical issue is the monitoring of the beam range so to check the correct dose deposition to the tumor and surrounding tissues. The design of a new tracking device for beam range real-time monitoring in pencil beam carbon ion therapy is presented. The proposed device tracks secondary charged particles produced by beam interactions in the patient tissue and exploits the correlation of the charged particle emission profile with the spatial dose deposition and the Bragg peak position...
January 19, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28109567/evaluation-of-residual-abdominal-tumour-motion-in-carbon-ion-gated-treatments-through-respiratory-motion-modelling
#10
Giorgia Meschini, Matteo Seregni, Andrea Pella, Mario Ciocca, Piero Fossati, Francesca Valvo, Marco Riboldi, Guido Baroni
At the Italian National Centre for Oncologic Hadrontherapy (CNAO) patients with upper-abdominal tumours are being treated with carbon ion therapy, adopting the respiratory gating technique in combination with layered rescanning and abdominal compression to mitigate organ motion. Since online imaging of the irradiated volume is not feasible, this study proposes a modelling approach for the estimation of residual motion of the target within the gating window. The model extracts a priori respiratory motion information from the planning 4DCT using deformable image registration (DIR), then combines such information with the external surrogate signal recorded during dose delivery...
January 18, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28092630/comparative-monte-carlo-study-on-the-performance-of-integration-and-list-mode-detector-configurations-for-carbon-ion-computed-tomography
#11
Sebastian Meyer, Chiara Gianoli, Lorena Magallanes, Benedikt Kopp, Thomas Tessonnier, Guillaume Landry, George Dedes, Bernd Voss, Katia Parodi
Ion beam therapy offers the possibility of a highly conformal tumor-dose distribution; however, this technique is extremely sensitive to inaccuracies in the treatment procedures. Ambiguities in the conversion of Hounsfield units of the treatment planning x-ray CT to relative stopping power (RSP) can cause uncertainties in the estimated ion range of up to several millimeters. Ion CT (iCT) represents a favorable solution allowing to directly assess the RSP. In this simulation study we investigate the performance of the integration-mode configuration for carbon iCT, in comparison with a single-particle approach under the same set-up...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28091564/mitotic-catastrophe-is-a-putative-mechanism-underlying-the-weak-correlation-between-sensitivity-to-carbon-ions-and-cisplatin
#12
Daijiro Kobayashi, Takahiro Oike, Atsushi Shibata, Atsuko Niimi, Yoshiki Kubota, Makoto Sakai, Napapat Amornwhichet, Yuya Yoshimoto, Yoshihiko Hagiwara, Yuka Kimura, Yuka Hirota, Hiro Sato, Mayu Isono, Yukari Yoshida, Takashi Kohno, Tatsuya Ohno, Takashi Nakano
In cancer therapy today, carbon ion radiotherapy is used mainly as monotherapy, whereas cisplatin is used concomitantly with X-ray radiotherapy. The effectiveness of concomitant carbon ions and cisplatin is unclear. To obtain the information on the mechanisms potentially shared between carbon ions or X-rays and cisplatin, we assessed the correlation of sensitivity to the single treatments. In 20 human cancer cell lines, sensitivity to X-rays strongly correlated with sensitivity to cisplatin, indicating the presence of potentially shared target mechanisms...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28090633/magnetic-field-effects-on-particle-beams-and-their-implications-for-dose-calculation-in-mr-guided-particle-therapy
#13
Hermann Fuchs, Philipp Moser, Martin Gröschl, Dietmar Georg
PURPOSE: To investigate and model effects of magnetic fields on proton and carbonion beams for dose calculation. METHODS: In a first step Monte Carlo simulations using Gate 7.1/Geant4.10.0.p03 were performed for proton and carbon ion beams in magnetic fields ranging from 0 to 3 T. Initial particle energies ranged from 60-250 MeV (protons) and 120-400 MeV/u (carbon ions), respectively. The resulting dose distributions were analyzed focusing on beam deflection, dose deformation as well as the impact of material het- erogeneities...
January 16, 2017: Medical Physics
https://www.readbyqxmd.com/read/28073579/robustness-of-4d-optimized-scanned-carbon-ion-beam-therapy-against-interfractional-changes-in-lung-cancer
#14
Christian Graeff
BACKGROUND AND PURPOSE: Moving targets could be conformally treated with actively scanned carbon ion beams using 4D-optimization. As this heavily exploits 4D-CTs, an important question is whether the conformity also upholds in the context of interfractional changes, i.e. variable positioning, anatomy and breathing patterns. MATERIALS AND METHODS: In 4 lung cancer patients, 6 weekly 4D-CTs were available. 4D-CTs and their phases were non-rigidly registered to propagate contours and 4D-doses...
January 7, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28068231/establishing-evidence-based-indications-for-proton-therapy-an-overview-of-current-clinical-trials
#15
Mark V Mishra, Sameer Aggarwal, Soren M Bentzen, Nancy Knight, Minesh P Mehta, William F Regine
PURPOSE: To review and assess ongoing proton beam therapy (PBT) clinical trials and to identify major gaps. METHODS AND MATERIALS: Active PBT clinical trials were identified from clinicaltrials.gov and the World Health Organization International Clinical Trials Platform Registry. Data on clinical trial disease site, age group, projected patient enrollment, expected start and end dates, study type, and funding source were extracted. RESULTS: A total of 122 active PBT clinical trials were identified, with target enrollment of >42,000 patients worldwide...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28048754/su-f-j-204-carbon-digitally-reconstructed-radiography-cdrr-a-gpu-based-tool-for-fast-and-versatile-carbonimaging-simulation
#16
M F Dias, J Seco, G Baroni, M Riboldi
PURPOSE: Research in carbon imaging has been growing over the past years, as a way to increase treatment accuracy and patient positioning in carbon therapy. The purpose of this tool is to allow a fast and flexible way to generate CDRR data without the need to use Monte Carlo (MC) simulations. It can also be used to predict future clinically measured data. METHODS: A python interface has been developed, which uses information from CT or 4DCT and thetreatment calibration curve to compute the Water Equivalent Path Length (WEPL) of carbon ions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048551/we-fg-brb-02-spatial-mapping-of-the-rbe-of-scanned-particle-beams
#17
D Grosshans
: The physical pattern of energy deposition and the enhanced relative biological effectiveness (RBE) of protons and carbon ions compared to photons offer unique and not fully understood or exploited opportunities to improve the efficacy of radiation therapy. Variations in RBE within a pristine or spread out Bragg peak and between particle types may be exploited to enhance cell killing in target regions without a corresponding increase in damage to normal tissue structures. In addition, the decreased sensitivity of hypoxic tumors to photon-based therapies may be partially overcome through the use of more densely ionizing radiations...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048464/su-c-brc-06-opencl-based-cross-platform-monte-carlo-simulation-package-for-carbon-ion-therapy
#18
N Qin, M Pinto, Z Tian, G Dedes, A Pompos, S Jiang, K Parodi, X Jia
PURPOSE: Monte Carlo (MC) simulation is considered to be the most accurate method for calculation of absorbed dose and fundamental physical quantities related to biological effects in carbon ion therapy. Its long computation time impedes clinical and research applications. We have developed an MC package, goCMC, on parallel processing platforms, aiming at achieving accurate and efficient simulations for carbon therapy. METHODS: goCMC was developed under OpenCL framework...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048340/su-f-j-190-time-resolved-range-measurement-system-using-scintillator-and-ccd-camera-for-the-slow-beam-extraction
#19
N Saotome, T Furukawa, K Mizushima, E Takeshita, Y Hara, Y Saraya, R Tansho, T Shirai, K Noda
PURPOSE: To investigate the time structure of the range, we have verified the rang shift due to the betatron tune shift with several synchrotron parameters. METHODS: A cylindrical plastic scintillator block and a CCD camera were installed on the black box. Using image processing, the range was determined the 80 percent of distal dose of the depth light distribution. The root mean square error of the range measurement using the scintillator and CCD system is about 0...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048194/we-fg-brb-01-clinical-significance-of-rbe-variations-in-proton-therapy
#20
H Paganetti
: The physical pattern of energy deposition and the enhanced relative biological effectiveness (RBE) of protons and carbon ions compared to photons offer unique and not fully understood or exploited opportunities to improve the efficacy of radiation therapy. Variations in RBE within a pristine or spread out Bragg peak and between particle types may be exploited to enhance cell killing in target regions without a corresponding increase in damage to normal tissue structures. In addition, the decreased sensitivity of hypoxic tumors to photon-based therapies may be partially overcome through the use of more densely ionizing radiations...
June 2016: Medical Physics
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