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https://www.readbyqxmd.com/read/28921785/cancer-specific-mortality-of-high-risk-prostate-cancer-after-carbon-ion-radiotherapy-plus-long-term-androgen-deprivation-therapy
#1
Goro Kasuya, Hitoshi Ishikawa, Hiroshi Tsuji, Yasuo Haruyama, Gen Kobashi, Daniel K Ebner, Koichiro Akakura, Hiroyoshi Suzuki, Tomohiko Ichikawa, Jun Shimazaki, Hirokazu Makishima, Takuma Nomiya, Tadashi Kamada, Hirohiko Tsujii
The treatment outcomes of patients with high-risk localized prostate cancer (PC) after carbon-ion radiotherapy (CIRT) combined with long-term androgen deprivation therapy (LTADT) were analyzed, and compared with those of other treatment modalities, focusing on PC-specific mortality (PCSM). A total of 1247 patients were enrolled in three phase II clinical trials of fixed-dose CIRT between 2000 and 2013. Excluding patients with T4 disease, 608 patients with high- or very-high-risk PC, according to the National Comprehensive Cancer Network classification system, who received CIRT with LTADT were evaluated...
September 16, 2017: Cancer Science
https://www.readbyqxmd.com/read/28918686/sensitivity-of-post-treatment-positron-emission-tomography-computed-tomography-to-detect-inter-fractional-range-variations-in-scanned-ion-beam-therapy
#2
Josefine Handrack, Thomas Tessonnier, Wenjing Chen, Jakob Liebl, Jürgen Debus, Julia Bauer, Katia Parodi
BACKGROUND: Ion therapy, especially with modern scanning beam delivery, offers very sharp dose gradients for highly conformal cancer treatment. However, it is very sensitive to uncertainties of tissue stopping properties as well as to anatomical changes and setup errors, making range verification highly desirable. To this end, positron emission tomography (PET) can be used to measure decay products of β(+)-emitters created in interactions inside the patient. This work investigates the sensitivity of post treatment PET/CT (computed tomography) to detect inter-fractional range variations...
September 18, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28895552/measurement-of-track-structure-parameters-of-low-and-medium-energy-helium-and-carbon-ions-in-nanometric-volumes
#3
G Hilgers, M U Bug, H Rabus
Ionization cluster size distributions produced in the sensitive volume of an ion-counting wall-less nanodosimeter by monoenergetic carbon ions with energies between 45 MeV and 150 MeV were measured at the TANDEM-ALPI ion accelerator facility complex of the LNL-INFN in Legnaro. Those produced by monoenergetic helium ions with energies between 2 MeV and 20 MeV were measured at the accelerator facilities of PTB and with a (241)Am alpha particle source. C3H8 was used as the target gas. The ionization cluster size distributions were measured in narrow beam geometry with the primary beam passing the target volume at specified distances from its centre, and in broad beam geometry with a fan-like primary beam...
September 12, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28886211/homogeneity-study-of-proton-and-carbon-ion-scanning-beams-using-combinations-of-different-spot-sizes-and-grid-sizes
#4
Ying Xing, Xianwei Wu, Yongqiang Li, Jun Zhao
PURPOSE: Different scanning ion beam delivery systems have different delivery accuracies, and the resulting delivery errors will affect field homogeneity. This study was performed to determine an appropriate combination of spot size (FWHM) and spot grid size (GS), which can provide homogenous dose distributions for both proton and carbon ion scanning beam radiotherapy. The combination of the two parameters is represented by a combination factor named n, which is the quotient of FWHM divided by GS...
September 8, 2017: Medical Physics
https://www.readbyqxmd.com/read/28880368/optimization-of-monte-carlo-particle-transport-parameters-and-validation-of-a-novel-high-throughput-experimental-setup-to-measure-the-biological-effects-of-particle-beams
#5
Darshana Patel, Lawrence Bronk, Fada Guan, Christopher R Peeler, Stephan Brons, Ivana Dokic, Amir Abdollahi, Claudia Rittmüller, Oliver Jäkel, David Grosshans, Radhe Mohan, Uwe Titt
PURPOSE: Accurate modeling of the relative biological effectiveness (RBE) of particle beams requires increased systematic in vitro studies with human cell lines with care towards minimizing uncertainties in biologic assays as well as physical parameters. In this study we describe a novel high-throughput experimental setup and an optimized parameterization of the Monte Carlo (MC) simulation technique that is universally applicable for accurate determination of RBE of clinical ion beams...
September 7, 2017: Medical Physics
https://www.readbyqxmd.com/read/28871995/a-multicenter-study-of-carbon-ion-radiation-therapy-for-head-and-neck-adenocarcinoma
#6
Jun-Ichi Saitoh, Masashi Koto, Yusuke Demizu, Hiroaki Suefuji, Tatsuya Ohno, Hiroshi Tsuji, Tomoaki Okimoto, Yoshiyuki Shioyama, Kenji Nemoto, Takashi Nakano, Tadashi Kamada
PURPOSE: Head and neck (HN) adenocarcinoma is rare, and to date, there have been no reports of prospective studies. We retrospectively evaluated the efficacy and safety of carbon-ion radiation therapy (C-ion RT) for HN adenocarcinoma in institutions in Japan. METHODS AND MATERIALS: HN adenocarcinoma patients with N0M0 or N1M0 disease who were treated with C-ion RT at institutions in Japan between November 2003 and December 2014 were analyzed retrospectively. We enrolled 47 patients (30 male and 17 female patients; median age, 60 years) with HN adenocarcinoma...
October 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28871342/a-systematic-review-of-publications-on-charged-particle-therapy-for-hepatocellular-carcinoma
#7
REVIEW
Hiroshi Igaki, Masashi Mizumoto, Toshiyuki Okumura, Kiyoshi Hasegawa, Norihiro Kokudo, Hideyuki Sakurai
Charged particle therapy (proton beam therapy and carbon ion therapy) is a form of radiotherapy which has the unique characteristic of superior depth dose distribution, and has been used for the treatment of hepatocellular carcinoma (HCC) in a limited number of patients, especially in Japan. We undertook a systematic review to define the clinical utility of charged particle therapy for patients with HCC. We searched the MEDLINE database from 1983 to June 2016 to identify clinical studies on charged particle therapy for HCC...
September 4, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28865463/carbon-ion-radiotherapy-for-non-small-cell-lung-cancer-with-interstitial-lung-disease-a%C3%A2-retrospective-analysis
#8
Mio Nakajima, Naoyoshi Yamamoto, Kazuhiko Hayashi, Masataka Karube, Daniel K Ebner, Wataru Takahashi, Makoto Anzai, Kenji Tsushima, Yuji Tada, Koichiro Tatsumi, Tadaaiki Miyamoto, Hiroshi Tsuji, Takehiko Fujisawa, Tadashi Kamada
BACKGROUND: Lung cancer is frequently complicated by interstitial lung disease (ILD). Treatment protocols for lung cancer patients with ILD have not been established; surgery, chemotherapy, and radiotherapy can all cause acute exacerbation of ILD. This study evaluated the toxicity and efficacy of carbon ion radiotherapy (CIRT) in patients with non-small cell lung cancer (NSCLC) and ILD. METHODS: Between June 2004 and November 2014, 29 patients diagnosed with NSCLC and ILD were treated with CIRT...
September 2, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28862152/tumor-control-in-ion-beam-radiotherapy-with-different-ions-in-presence-of-hypoxia-an-oxygen-enhancement-ratio-model-based-on-the-microdosimetric-kinetic-model
#9
Lidia Strigari, Francesca Torriani, Lorenzo Manganaro, Taku Inaniwa, Federico Dalmasso, Roberto Cirio, Andrea Attili
Few attempts to include the oxygen enhancement ratio (OER) in treatment planning for ion beam therapy have been made and systematic studies to evaluate the impact of hypoxia in treatments with beam of different ion species are missing. The radiobiological models used to quantify the OER in such studies are mainly based on the dose-averaged LET estimates and do not explicitly distinguish between ion species and fractionation schemes. In this study a new OER modelling, based on the microdosimetric kinetic model, taking into account the specificity of the different ions, LET spectra, tissues and fractionation schemes, has been developed...
September 1, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28841579/oxygen-beams-for-therapy-advanced-biological-treatment-planning-and-experimental-verification
#10
O Sokol, E Scifoni, W Tinganelli, W Kraft-Weyrather, J Wiedemann, A Maier, D Boscolo, T Friedrich, S Brons, M Durante, M Krämer
Nowadays there is a rising interest towards exploiting new therapeutical beams beyond carbon ions and protons. In particular, [Formula: see text]O ions are being widely discussed due to their increased LET distribution. In this contribution, we report on the first experimental verification of biologically optimized treatment plans, accounting for different biological effects, generated with the TRiP98 planning system with [Formula: see text]O beams, performed at HIT and GSI. This implies the measurements of 3D profiles of absorbed dose as well as several biological measurements...
September 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28815184/evaluation-of-risk-factors-for-vertebral-compression-fracture-after-carbon-ion-radiotherapy-for-primary-spinal-and-paraspinal-sarcoma
#11
Yoshihiro Matsumoto, Makoto Shinoto, Makoto Endo, Nokitaka Setsu, Keiichiro Iida, Jun-Ichi Fukushi, Kenichi Kawaguchi, Seiji Okada, Hirofumi Bekki, Reiko Imai, Tadashi Kamada, Yoshiyuki Shioyama, Yasuharu Nakashima
BACKGROUND AND PURPOSE: Carbon-ion radiotherapy (C-ion RT) was effective therapy for inoperable spinal and paraspinal sarcomas. However, a significant adverse event following radiotherapies is vertebral compression fractures (VCFs). In this study, we investigated the incidence of and risk factors for post-C-ion RT VCFs in patients with spinal or paraspinal sarcomas. MATERIAL AND METHODS: Thirty consecutive patients with spinal or paraspinal sarcomas treated with C-ion RT were retrospectively reviewed...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28810881/comparison-of-photon-volumetric-modulated-arc-therapy-intensity-modulated-proton-therapy-and-intensity-modulated-carbon-ion-therapy-for-delivery-of-hypo-fractionated-thoracic-radiotherapy
#12
Alexander Chi, Lien-Chun Lin, Sijin Wen, Haijuan Yan, Wen-Chien Hsi
PURPOSE: The aim of the present study was to compare the dose distribution generated from photon volumetric modulated arc therapy (VMAT), intensity modulated proton therapy (IMPT), and intensity modulated carbon ion therapy (IMCIT) in the delivery of hypo-fractionated thoracic radiotherapy. METHODS AND MATERIALS: Ten selected patients who underwent thoracic particle therapy between 2015 and 2016 were re-planned to receive a relative biological effectiveness (RBE) weighted dose of 60 Gy (i...
August 15, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28791440/therapeutic-potentials-of-short-interfering-rnas
#13
REVIEW
Chit Tam, Jack Ho Wong, Randy Chi Fai Cheung, Tao Zuo, Tzi Bun Ng
Short interfering RNA (siRNA) is one of the members of the family of RNA interference (RNAi). Coupled with the RNA-induced silencing complex (RISC), siRNA is able to trigger the cleavage of target RNAs which serve as a defensive system against pathogens. Meanwhile, siRNA in gene silencing opens a new avenue for the treatment of various diseases. SiRNA can effectively inhibit viral infection and replication and suppress tumorigenesis and various inflammation-associated diseases and cardiovascular diseases by inactivation of viral genes and downregulation of oncogene expression...
August 8, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28764925/profile-of-european-proton-and-carbon-ion-therapy-centers-assessed-by-the-eortc-facility-questionnaire
#14
Damien C Weber, André Abrunhosa-Branquinho, Alessandra Bolsi, Andrzej Kacperek, Rémi Dendale, Dirk Geismar, Barbara Bachtiary, Annika Hall, Jens Heufelder, Klaus Herfarth, Jürgen Debus, Maurizio Amichetti, Mechthild Krause, Roberto Orecchia, Vladimir Vondracek, Juliette Thariat, Tomasz Kajdrowicz, Kristina Nilsson, Cai Grau
BACKGROUND: We performed a survey using the modified EORTC Facility questionnaire (pFQ) to evaluate the human, technical and organizational resources of particle centers in Europe. MATERIAL AND METHODS: The modified pFQ consisted of 235 questions distributed in 11 sections accessible on line on an EORTC server. Fifteen centers from 8 countries completed the pFQ between May 2015 and December 2015. RESULTS: The average number of patients treated per year and per particle center was 221 (range, 40-557)...
July 29, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28762335/helium-ions-at-the-heidelberg-ion-beam-therapy-center-comparisons-between-fluka-monte-carlo-code-predictions-and-dosimetric-measurements
#15
T Tessonnier, A Mairani, S Brons, P Sala, F Cerutti, A Ferrari, T Haberer, J Debus, K Parodi
In the field of particle therapy helium ion beams could offer an alternative for radiotherapy treatments, owing to their interesting physical and biological properties intermediate between protons and carbon ions. We present in this work the comparisons and validations of the Monte Carlo FLUKA code against in-depth dosimetric measurements acquired at the Heidelberg Ion Beam Therapy Center (HIT). Depth dose distributions in water with and without ripple filter, lateral profiles at different depths in water and a spread-out Bragg peak were investigated...
August 1, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28730646/prospective-observational-study-of-carbon-ion-radiotherapy-for-non-squamous-cell-carcinoma-of-the-head-and-neck
#16
Katsuyuki Shirai, Jun-Ichi Saitoh, Atsushi Musha, Takanori Abe, Daijiro Kobayashi, Takeo Takahashi, Tomoaki Tamaki, Hidemasa Kawamura, Yukihiro Takayasu, Masato Shino, Minoru Toyoda, Katsumasa Takahashi, Junko Hirato, Satoshi Yokoo, Kazuaki Chikamatsu, Tatsuya Ohno, Tatsuya Nakano
To evaluate the efficacy and safety of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck, 35 patients were enrolled in this prospective study. The primary end-point was the 3-year local control rate, and the secondary end-points included the 3-year overall survival rate and adverse events. Acute and late adverse events were evaluated according to the Common Terminology Criteria for Adverse Events, version 4.0. The median follow-up time for all patients was 39 months. Thirty-two and three patients received 64...
July 21, 2017: Cancer Science
https://www.readbyqxmd.com/read/28727901/carbon-ion-radiotherapy-for-isolated-para-aortic-lymph-node-recurrence-from-colorectal-cancer
#17
Yuka Isozaki, Shigeru Yamada, Shohei Kawashiro, Shigeo Yasuda, Naomi Okada, Daniel Ebner, Hiroshi Tsuji, Tadashi Kamada, Hisahiro Matsubara
BACKGROUND: The safety and effectiveness of carbon-ion radiotherapy (CIRT) for isolated para-aortic lymph node (PALN) metastasis was evaluated retrospectively. METHODS: CIRT for isolated PALN metastasis from CRC was performed in 34 cases from June 2006 to August 2015 in our institute. A median dose of 52.8 Gy(RBE) (range, 48-52.8 Gy(RBE)) was delivered with a median daily dose of 4.4 Gy(RBE) (range, 4.0-4.4 Gy(RBE)). RESULTS: The median follow-up duration for all patients was 24...
July 20, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28718770/benchmarking-gate-geant4-for-16-o-ion-beam-therapy
#18
Andreas F Resch, Hermann Fuchs, Dietmar Georg
Oxygen ([Formula: see text]) ions are a potential alternative to carbon ions in ion beam therapy. Their enhanced linear energy transfer indicates a higher relative biological effectiveness and a reduced oxygen enhancement ratio. Due to the limited availability of [Formula: see text] ion beams, Monte Carlo (MC) transport codes are important research tools for investigating their potential. The purpose of this study was to validate GATE/Geant4 for [Formula: see text] ion beam therapy using experimental data from literature...
September 5, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28703340/core-satellite-polydopamine-gadolinium-metallofullerene-nanotheranostics-for-multimodal-imaging-guided-combination-cancer-therapy
#19
Sheng Wang, Jing Lin, Zhantong Wang, Zijian Zhou, Ruiliang Bai, Nan Lu, Yijing Liu, Xiao Fu, Orit Jacobson, Wenpei Fan, Junle Qu, Siping Chen, Tianfu Wang, Peng Huang, Xiaoyuan Chen
Integration of magnetic resonance imaging (MRI) and other imaging modalities is promising to furnish complementary information for accurate cancer diagnosis and imaging-guided therapy. However, most gadolinium (Gd)-chelator MR contrast agents are limited by their relatively low relaxivity and high risk of released-Gd-ions-associated toxicity. Herein, a radionuclide-(64) Cu-labeled doxorubicin-loaded polydopamine (PDA)-gadolinium-metallofullerene core-satellite nanotheranostic agent (denoted as CDPGM) is developed for MR/photoacoustic (PA)/positron emission tomography (PET) multimodal imaging-guided combination cancer therapy...
September 2017: Advanced Materials
https://www.readbyqxmd.com/read/28661074/a-review-of-recent-developments-of-mesoporous-materials
#20
REVIEW
Steven L Suib
This personal account concerns novel recent discoveries in the area of mesoporous materials. Most of the papers discussed have been published within the last two to three years. A major emphasis of most of these papers is the synthesis of unique mesoporous materials by a variety of synthetic methods. Many of these articles focus on the control of the pore sizes and shapes of mesoporous materials. Synthetic methods of various types have been used for such control of porosity including soft templating, hard templating, nano-casting, electrochemical methods, surface functionalization, and trapping of species in pores...
June 29, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
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