keyword
MENU ▼
Read by QxMD icon Read
search

Carbon ion therapy

keyword
https://www.readbyqxmd.com/read/28092630/comparative-monte-carlo-study-on-the-performance-of-integration-and-list-mode-detector-configurations-for-carbon-ion-computed-tomography
#1
Sebastian Meyer, Chiara Gianoli, Lorena Magallanes, Benedikt Kopp, Thomas Tessonnier, Guillaume Landry, George Dedes, Bernd Voss, Katia Parodi
Ion beam therapy offers the possibility of a highly conformal tumor-dose distribution; however, this technique is extremely sensitive to inaccuracies in the treatment procedures. Ambiguities in the conversion of Hounsfield units of the treatment planning x-ray CT to relative stopping power (RSP) can cause uncertainties in the estimated ion range of up to several millimeters. Ion CT (iCT) represents a favorable solution allowing to directly assess the RSP. In this simulation study we investigate the performance of the integration-mode configuration for carbon iCT, in comparison with a single-particle approach under the same set-up...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28091564/mitotic-catastrophe-is-a-putative-mechanism-underlying-the-weak-correlation-between-sensitivity-to-carbon-ions-and-cisplatin
#2
Daijiro Kobayashi, Takahiro Oike, Atsushi Shibata, Atsuko Niimi, Yoshiki Kubota, Makoto Sakai, Napapat Amornwhichet, Yuya Yoshimoto, Yoshihiko Hagiwara, Yuka Kimura, Yuka Hirota, Hiro Sato, Mayu Isono, Yukari Yoshida, Takashi Kohno, Tatsuya Ohno, Takashi Nakano
In cancer therapy today, carbon ion radiotherapy is used mainly as monotherapy, whereas cisplatin is used concomitantly with X-ray radiotherapy. The effectiveness of concomitant carbon ions and cisplatin is unclear. To obtain the information on the mechanisms potentially shared between carbon ions or X-rays and cisplatin, we assessed the correlation of sensitivity to the single treatments. In 20 human cancer cell lines, sensitivity to X-rays strongly correlated with sensitivity to cisplatin, indicating the presence of potentially shared target mechanisms...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28090633/magnetic-field-effects-on-particle-beams-and-their-implications-for-dose-calculation-in-mr-guided-particle-therapy
#3
Hermann Fuchs, Philipp Moser, Martin Gröschl, Dietmar Georg
PURPOSE: To investigate and model effects of magnetic fields on proton and carbonion beams for dose calculation. METHODS: In a first step Monte Carlo simulations using Gate 7.1/Geant4.10.0.p03 were performed for proton and carbon ion beams in magnetic fields ranging from 0 to 3 T. Initial particle energies ranged from 60-250 MeV (protons) and 120-400 MeV/u (carbon ions), respectively. The resulting dose distributions were analyzed focusing on beam deflection, dose deformation as well as the impact of material het- erogeneities...
January 16, 2017: Medical Physics
https://www.readbyqxmd.com/read/28073579/robustness-of-4d-optimized-scanned-carbon-ion-beam-therapy-against-interfractional-changes-in-lung-cancer
#4
Christian Graeff
BACKGROUND AND PURPOSE: Moving targets could be conformally treated with actively scanned carbon ion beams using 4D-optimization. As this heavily exploits 4D-CTs, an important question is whether the conformity also upholds in the context of interfractional changes, i.e. variable positioning, anatomy and breathing patterns. MATERIALS AND METHODS: In 4 lung cancer patients, 6 weekly 4D-CTs were available. 4D-CTs and their phases were non-rigidly registered to propagate contours and 4D-doses...
January 7, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28068231/establishing-evidence-based-indications-for-proton-therapy-an-overview-of-current-clinical-trials
#5
Mark V Mishra, Sameer Aggarwal, Soren M Bentzen, Nancy Knight, Minesh P Mehta, William F Regine
PURPOSE: To review and assess ongoing proton beam therapy (PBT) clinical trials and to identify major gaps. METHODS AND MATERIALS: Active PBT clinical trials were identified from clinicaltrials.gov and the World Health Organization International Clinical Trials Platform Registry. Data on clinical trial disease site, age group, projected patient enrollment, expected start and end dates, study type, and funding source were extracted. RESULTS: A total of 122 active PBT clinical trials were identified, with target enrollment of >42,000 patients worldwide...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28048754/su-f-j-204-carbon-digitally-reconstructed-radiography-cdrr-a-gpu-based-tool-for-fast-and-versatile-carbonimaging-simulation
#6
M F Dias, J Seco, G Baroni, M Riboldi
PURPOSE: Research in carbon imaging has been growing over the past years, as a way to increase treatment accuracy and patient positioning in carbon therapy. The purpose of this tool is to allow a fast and flexible way to generate CDRR data without the need to use Monte Carlo (MC) simulations. It can also be used to predict future clinically measured data. METHODS: A python interface has been developed, which uses information from CT or 4DCT and thetreatment calibration curve to compute the Water Equivalent Path Length (WEPL) of carbon ions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048551/we-fg-brb-02-spatial-mapping-of-the-rbe-of-scanned-particle-beams
#7
D Grosshans
: The physical pattern of energy deposition and the enhanced relative biological effectiveness (RBE) of protons and carbon ions compared to photons offer unique and not fully understood or exploited opportunities to improve the efficacy of radiation therapy. Variations in RBE within a pristine or spread out Bragg peak and between particle types may be exploited to enhance cell killing in target regions without a corresponding increase in damage to normal tissue structures. In addition, the decreased sensitivity of hypoxic tumors to photon-based therapies may be partially overcome through the use of more densely ionizing radiations...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048464/su-c-brc-06-opencl-based-cross-platform-monte-carlo-simulation-package-for-carbon-ion-therapy
#8
N Qin, M Pinto, Z Tian, G Dedes, A Pompos, S Jiang, K Parodi, X Jia
PURPOSE: Monte Carlo (MC) simulation is considered to be the most accurate method for calculation of absorbed dose and fundamental physical quantities related to biological effects in carbon ion therapy. Its long computation time impedes clinical and research applications. We have developed an MC package, goCMC, on parallel processing platforms, aiming at achieving accurate and efficient simulations for carbon therapy. METHODS: goCMC was developed under OpenCL framework...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048340/su-f-j-190-time-resolved-range-measurement-system-using-scintillator-and-ccd-camera-for-the-slow-beam-extraction
#9
N Saotome, T Furukawa, K Mizushima, E Takeshita, Y Hara, Y Saraya, R Tansho, T Shirai, K Noda
PURPOSE: To investigate the time structure of the range, we have verified the rang shift due to the betatron tune shift with several synchrotron parameters. METHODS: A cylindrical plastic scintillator block and a CCD camera were installed on the black box. Using image processing, the range was determined the 80 percent of distal dose of the depth light distribution. The root mean square error of the range measurement using the scintillator and CCD system is about 0...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048194/we-fg-brb-01-clinical-significance-of-rbe-variations-in-proton-therapy
#10
H Paganetti
: The physical pattern of energy deposition and the enhanced relative biological effectiveness (RBE) of protons and carbon ions compared to photons offer unique and not fully understood or exploited opportunities to improve the efficacy of radiation therapy. Variations in RBE within a pristine or spread out Bragg peak and between particle types may be exploited to enhance cell killing in target regions without a corresponding increase in damage to normal tissue structures. In addition, the decreased sensitivity of hypoxic tumors to photon-based therapies may be partially overcome through the use of more densely ionizing radiations...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048070/su-f-t-149-development-of-the-monte-carlo-simulation-platform-using-geant4-for-designing-heavy-ion-therapy-beam-nozzle
#11
Jae-Ik Shin, SeungHoon Yoo, Sungho Cho, Eun Ho Kim, Yongkeun Song, Won-Gyun Jung
PURPOSE: The significant issue of particle therapy such as proton and carbon ion was a accurate dose delivery from beam line to patient. For designing the complex delivery system, Monte Carlo simulation can be used for the simulation of various physical interaction in scatters and filters. In this report, we present the development of Monte Carlo simulation platform to help design the prototype of particle therapy nozzle and performed the Monte Carlo simulation using Geant4. Also we show the prototype design of particle therapy beam nozzle for Korea Heavy Ion Medical Accelerator (KHIMA) project in Korea Institute of Radiological and Medical Science(KIRAMS) at Republic of Korea...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048036/su-f-t-200-dosimetric-variation-of-organs-at-risk-for-recurrent-nasopharyngeal-carcinoma-rnpc-patients-treated-by-carbon-ion-beams
#12
W Wang, Y Sheng, K Shahnazi
PURPOSE: Investigate the factors which affect the doses of organs at risk (OARs) for head and neck carbon ion therapy. METHODS: Ten locally recurrent nasopharyngeal carcinoma cases with similar prescriptions were selected. All patients' organs at risk (OARs) as well as CTVs were contoured by an experienced physician. Carbon ion treatment plans were created using a Syngo treatment planning system (Siemens, Germany). The CTVs were expanded to make optimized target volumes (OTVs) by considering treatment uncertainties and OAR protections...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047192/su-c-204-04-irradiation-of-human-cell-lines-using-various-ions
#13
Y Lin, C Tessa, A Rusek, S McMahon, T Kaminuma, K Held
PURPOSE: The purpose of this study is to investigate and quantify the biological effects of ion radiation using several human cell lines. We aim to answer the question of whether carbon ion the most ideal ion species for heavy ion radiotherapy. METHODS: The cells were irradiated at different positions along the pristine Bragg peak of several ions with different atomic number. The biological effectiveness was evaluated using the clonogenic cell survival assay. Irradiation of three human lung cancer cell lines and a fibroblast cell line were undertaken using the charged particle beam at the NASA Space Radiation Laboratory at Brookhaven National Lab...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047053/we-h-bra-06-experimental-investigation-of-rbe-for-lung-cancer-cell-lines-as-a-function-of-dose-and-let-in-proton-helium-and-carbon-beams
#14
D Patel, L Bronk, F Guan, C Peeler, D Mirkovic, D Grosshans, O Jakel, A Abdollahi, U Titt, R Mohan
PURPOSE: Investigate and quantify the effect of dose and LET on the RBE of protons, helium and carbon ions. METHODS: High throughput, high accuracy experimental setups were custom designed to investigate the Relative Biological Effectiveness (RBE) dependence on the dose and Linear Energy Transfer (LET) values for proton, helium and carbon ion beams. The experiment was conducted at the HIT facility in collaboration with the DKFZ in Heidelberg/Germany. Clonogenic assays of two human lung cancer cell lines, H460 and H1437, were investigated in this study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046959/we-fg-brb-03-challenges-and-opportunities-for-implementing-biological-optimization-in-particle-therapy
#15
D Carlson
: The physical pattern of energy deposition and the enhanced relative biological effectiveness (RBE) of protons and carbon ions compared to photons offer unique and not fully understood or exploited opportunities to improve the efficacy of radiation therapy. Variations in RBE within a pristine or spread out Bragg peak and between particle types may be exploited to enhance cell killing in target regions without a corresponding increase in damage to normal tissue structures. In addition, the decreased sensitivity of hypoxic tumors to photon-based therapies may be partially overcome through the use of more densely ionizing radiations...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046745/tu-ab-brc-02-accuracy-evaluation-of-gpu-based-opencl-carbon-monte-carlo-package-gocmc-in-biological-dose-and-microdosimetry-in-comparison-to-fluka-simulations
#16
R Taleei, C Peeler, N Qin, S Jiang, X Jia
PURPOSE: One of the most accurate methods for radiation transport is Monte Carlo (MC) simulation. Long computation time prevents its wide applications in clinic. We have recently developed a fast MC code for carbon ion therapy called GPU-based OpenCL Carbon Monte Carlo (goCMC) and its accuracy in physical dose has been established. Since radiobiology is an indispensible aspect of carbon ion therapy, this study evaluates accuracy of goCMC in biological dose and microdosimetry by benchmarking it with FLUKA...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046645/su-f-t-125-radial-dose-distributions-from-carbon-ions-of-therapeutic-energies-calculated-with-geant4-dna
#17
O Vassiliev
PURPOSE: Radial dose distribution D(r) is the dose as a function of lateral distance from the path of a heavy charged particle. Its main application is in modelling of biological effects of heavy ions, including applications to hadron therapy. It is the main physical parameter of a broad group of radiobiological models known as the amorphous track models. Our purpose was to calculate D(r) with Monte Carlo for carbon ions of therapeutic energies, find a simple formula for D(r) and fit it to the Monte Carlo data...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046508/we-fg-brb-00-the-challenges-of-predicting-rbe-effects-in-particle-therapy-and-opportunities-for-improving-cancer-therapy
#18
David Carlson
: The physical pattern of energy deposition and the enhanced relative biological effectiveness (RBE) of protons and carbon ions compared to photons offer unique and not fully understood or exploited opportunities to improve the efficacy of radiation therapy. Variations in RBE within a pristine or spread out Bragg peak and between particle types may be exploited to enhance cell killing in target regions without a corresponding increase in damage to normal tissue structures. In addition, the decreased sensitivity of hypoxic tumors to photon-based therapies may be partially overcome through the use of more densely ionizing radiations...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046397/we-h-bra-07-mechanistic-modelling-of-the-relative-biological-effectiveness-of-heavy-charged-particles
#19
S McMahon, A McNamara, J Schuemann, K Prise, H Paganetti
Purpose Uncertainty in the Relative Biological Effectiveness (RBE) of heavy charged particles compared to photons remains one of the major uncertainties in particle therapy. As RBEs depend strongly on clinical variables such as tissue type, dose, and radiation quality, more accurate individualised models are needed to fully optimise treatments. MethodsWe have developed a model of DNA damage and repair following X-ray irradiation in a number of settings, incorporating mechanistic descriptions of DNA repair pathways, geometric effects on DNA repair, cell cycle effects and cell death...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046299/we-fg-brb-04-rbes-for-human-lung-cancer-cells-exposed-to-protons-and-heavier-ions-implications-for-clinical-use-of-charged-particles-in-cancer-therapy
#20
K Held
: The physical pattern of energy deposition and the enhanced relative biological effectiveness (RBE) of protons and carbon ions compared to photons offer unique and not fully understood or exploited opportunities to improve the efficacy of radiation therapy. Variations in RBE within a pristine or spread out Bragg peak and between particle types may be exploited to enhance cell killing in target regions without a corresponding increase in damage to normal tissue structures. In addition, the decreased sensitivity of hypoxic tumors to photon-based therapies may be partially overcome through the use of more densely ionizing radiations...
June 2016: Medical Physics
keyword
keyword
54248
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"