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Carbon ion therapy

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https://www.readbyqxmd.com/read/29325596/late-normal-tissue-response-in-the-rat-spinal-cord-after-carbon-ion-irradiation
#1
Maria Saager, Peter Peschke, Thomas Welzel, Lifi Huang, Stephan Brons, Rebecca Grün, Michael Scholz, Jürgen Debus, Christian P Karger
BACKGROUND: The present work summarizes the research activities on radiation-induced late effects in the rat spinal cord carried out within the "clinical research group ion beam therapy" funded by the German Research Foundation (DFG, KFO 214). METHODS AND MATERIALS: Dose-response curves for the endpoint radiation-induced myelopathy were determined at 6 different positions (LET 16-99 keV/μm) within a 6 cm spread-out Bragg peak using either 1, 2 or 6 fractions of carbon ions...
January 11, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29320576/targeting-dna-repair-with-pnkp-inhibition-sensitizes-radioresistant-prostate-cancer-cells-to-high-let-radiation
#2
Pallavi Srivastava, Asitikantha Sarma, Chandra Mohini Chaturvedi
High linear energy transfer (LET) radiation or heavy ion such as carbon ion radiation is used as a method for advanced radiotherapy in the treatment of cancer. It has many advantages over the conventional photon based radiotherapy using Co-60 gamma or high energy X-rays from a Linear Accelerator. However, charged particle therapy is very costly. One way to reduce the cost as well as irradiation effects on normal cells is to reduce the dose of radiation by enhancing the radiation sensitivity through the use of a radiomodulator...
2018: PloS One
https://www.readbyqxmd.com/read/29319842/quantitative-evaluation-of-potential-irradiation-geometries-for-carbon-ion-beam-grid-therapy
#3
Toshiro Tsubouchi, Thomas Henry, Ana Ureba, Alexander Valdman, Niels Bassler, Albert Siegbahn
PURPOSE: Radiotherapy using grids containing cm-wide beam elements has been carried out sporadically for more than a century. During the past two decades, preclinical research on radiotherapy with grids containing small beam elements, 25 μm - 0.7 mm wide, has been performed. Grid therapy with larger beam elements is technically easier to implement, but the normal-tissue tolerance to the treatment is decreasing. In this work, a new approach in grid therapy, based on irradiations with grids containing narrow carbon-ion beam elements was evaluated dosimetrically...
January 10, 2018: Medical Physics
https://www.readbyqxmd.com/read/29311417/theoretical-and-experimental-comparison-of-proton-and-helium-beam-radiography-using-silicon-pixel-detectors
#4
Tim Gehrke, Carlo Amato, Simon Berke, Maria Martisikova
Ion-beam radiography (iRAD) could potentially improve the quality control of ion-beam therapy. The main advantage of iRAD is the possibility to directly measure the integrated stopping power. Until now there is no clinical implementation of iRAD. Topics of ongoing research include developing dedicated detection systems to achieve the desired spatial resolution (SR) and investigating different ion types as imaging radiation. This work focuses on the theoretical and experimental comparison of proton (pRAD) and helium-beam radiography (αRAD)...
January 9, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29310404/extracorporeal-membrane-oxygenation-combined-with-continuous-renal-replacement-therapy-in-cutaneous-burn-and-inhalation-injury-caused-by-hydrofluoric-acid-and-nitric-acid
#5
Qinhua Pu, Jinxian Qian, Weiyi Tao, Aixiang Yang, Jian Wu, Yaodong Wang
RATIONALE: Hydrofluoric acid (HF) is a highly corrosive agent and can cause corrosive burns. HF can penetrate deeply into tissues through intact skin and the lipid barrier, leading to painful liquefactive necrosis, and inducing hypocalcemia and hypomagnesemia. In this study, we hypothesize that continuous renal replacement therapy (CRRT) may be beneficial in addressing hemodynamic instability in cases of HF poisoning. PATIENT CONCERNS: A 25-year-old man fell into an electroplating pool containing 10% HF and 50% nitric acid...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29304828/oncogene-addiction-and-radiation-oncology-effect-of-radiotherapy-with-photons-and-carbon-ions-in-alk-eml4-translocated-nsclc
#6
Ying Dai, Quanxiang Wei, Christian Schwager, Janina Hanne, Cheng Zhou, Klaus Herfarth, Stefan Rieken, Kenneth E Lipson, Jürgen Debus, Amir Abdollahi
BACKGROUND: Patients with Echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) positive lung cancer are sensitive to ALK-kinase inhibitors. TAE684 is a potent second generation ALK inhibitor that overcomes Crizotinib resistance. Radiotherapy is an integral therapeutic component of locally advanced lung cancer. Therefore, we sought to investigate the effects of combined radiotherapy and ALK-inhibition via TAE684 in ALK-positive vs. wild type lung cancer cells...
January 5, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29261194/calcium-based-biomaterials-for-diagnosis-treatment-and-theranostics
#7
REVIEW
Chao Qi, Jing Lin, Lian-Hua Fu, Peng Huang
Calcium-based (CaXs) biomaterials including calcium phosphates, calcium carbonates, calcium silicate and calcium fluoride have been widely utilized in the biomedical field owing to their excellent biocompatibility and biodegradability. In recent years, CaXs biomaterials have been strategically integrated with imaging contrast agents and therapeutic agents for various molecular imaging modalities including fluorescence imaging, magnetic resonance imaging, ultrasound imaging or multimodal imaging, as well as for various therapeutic approaches including chemotherapy, gene therapy, hyperthermia therapy, photodynamic therapy, radiation therapy, or combination therapy, even imaging-guided therapy...
December 20, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/29260843/hyperthemia-promoted-cytosolic-and-nuclear-delivery-of-copper-carbon-quantum-dot-crosslinked-nanosheets-multimodal-imaging-guided-photothermal-cancer-therapy
#8
Yan-Wen Bao, Xian-Wu Hua, Yan-Hong Li, Hao-Ran Jia, Fu-Gen Wu
Copper-containing nanomaterials have been applied in various fields due to their appealing physical, chemical, and biomedical properties/functions. Herein, for the first time, a facile, room-temperature and one-pot method of simply mixing copper ions and sulfur-doped CDs is developed for the synthesis of copper/carbon quantum dot (or carbon dot, CD)-crosslinked nanosheets (CuCD NSs). The thus-obtained CuCD NSs with the size of 20-30 nm had a high photothermal conversion efficiency of 41.3% and good photothermal stability...
December 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29240558/a-modified-microdosimetric-kinetic-model-for-relative-biological-effectiveness-calculation
#9
Yizheng Chen, Junli Li, Chunyan Li, Rui Qiu, Zhen Wu
In the heavy ion therapy, not only the distribution of physical absorbed dose, but also the relative biological effectiveness (RBE) weighted dose needs to be taken into account. The microdosimetric kinetic model (MKM) can predict the RBE value of heavy ions with saturation-corrected dose-mean specific energy, which has been used in clinical treatment planning at the National Institute of Radiological Sciences. In the theoretical assumption of the MKM, the yield of the primary lesion is independent of the radiation quality, while the experimental data shows that DNA double strand break (DSB) yield, considered as the main primary lesion, depends on the LET of the particle...
December 14, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29235991/imaging-of-monochromatic-beams-by-measuring-secondary-electron-bremsstrahlung-for-carbon-ion-therapy-using-a-pinhole-x-ray-camera
#10
Mitsutaka Yamaguchi, Yuto Nagao, Koki Ando, Seiichi Yamamoto, Makoto Sakai, Raj Kumar Parajuli, Kazuo Arakawa, Naoki Kawachi
A feasibility study on the imaging of monochromatic carbon-ion beams for carbon-ion therapy was performed. The evaluation was based on Monte Carlo simulations and beam-irradiation experiments, using a pinhole X-ray camera, which measured secondary electron bremsstrahlung (SEB). The simulation results indicated that the trajectories of the carbon-ion beams with injection energies of 278, 249 and 218 MeV/u in a water phantom, were clearly imaged by measuring the SEB with energies from 30 to 60 keV, using a pinhole camera...
December 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29225692/recent-advances-in-radiation-oncology
#11
REVIEW
Cristina Garibaldi, Barbara Alicja Jereczek-Fossa, Giulia Marvaso, Samantha Dicuonzo, Damaris Patricia Rojas, Federica Cattani, Anna Starzyńska, Delia Ciardo, Alessia Surgo, Maria Cristina Leonardi, Rosalinda Ricotti
Radiotherapy (RT) is very much a technology-driven treatment modality in the management of cancer. RT techniques have changed significantly over the past few decades, thanks to improvements in engineering and computing. We aim to highlight the recent developments in radiation oncology, focusing on the technological and biological advances. We will present state-of-the-art treatment techniques, employing photon beams, such as intensity-modulated RT, volumetric-modulated arc therapy, stereotactic body RT and adaptive RT, which make possible a highly tailored dose distribution with maximum normal tissue sparing...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29213338/particle-therapy-and-nanomedicine-state-of-art-and-research-perspectives
#12
REVIEW
Sandrine Lacombe, Erika Porcel, Emanuele Scifoni
Cancer radiation therapy with charged particle beams, called particle therapy, is a new therapeutic treatment presenting major advantages when compared to conventional radiotherapy. Because ions have specific ballistic properties and a higher biological effectiveness, they are superior to x-rays. Numerous medical centres are starting in the world using mostly protons but also carbon ions as medical beams. Several investigations are attempting to reduce the cost/benefit ratio and enlarge the range of therapeutic indications...
2017: Cancer Nanotechnology
https://www.readbyqxmd.com/read/29195556/immobilization-for-carbon-ion-beam-ablation-of-cardiac-structures-in-a-porcine-model
#13
Matthias Prall, Anna Eichhorn, Daniel Richter, H Immo Lehmann, Anna Constantinescu, Robert Kaderka, Patrick Lugenbiel, Dierk Thomas, Christoph Bert, Douglas L Packer, Marco Durante, Christian Graeff
INTRODUCTION: Whereas hadron therapy of static targets is clinically established, treatment of moving organs remains a challenge. One strategy is to minimize motion of surrounding tissue mechanically and to mitigate residual motion with an appropriate irradiation technique. In this technical note, we present and characterize such an immobilization technique for a novel noncancerous application: the irradiation of small targets in hearts with scanned carbon ion beams in a porcine model for elimination of arrhythmias...
November 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29195506/treatment-of-meningioma-and-glioma-with-protons-and-carbon-ions
#14
REVIEW
Sebastian Adeberg, Semi B Harrabi, Vivek Verma, Denise Bernhardt, Nicole Grau, Jürgen Debus, Stefan Rieken
The rapid rise of particle therapy across the world necessitates evidence to justify its ever-increasing utilization. This narrative review summarizes the current status of these technologies on treatment of both meningiomas and gliomas, the most common benign and malignant primary brain tumors, respectively. Proton beam therapy (PBT) for meningiomas displays high rates of long-term local control, low rates of symptomatic deterioration, along with the potential for safe dose-escalation in select (but not necessarily routine) cases...
December 1, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29187480/clinical-efficacy-of-carbon-ion-radiotherapy-for-unresectable-chondrosarcomas
#15
Reiko Imai, Tadashi Kamada, Nobuhito Araki
BACKGROUND: Carbon ion radiotherapy has precise dose distribution and high biological effectiveness and is likely a promising therapy for patients with sarcomas. We evaluated the outcomes of carbon ion radiotherapy in patients with unresectable chondrosarcomas. PATIENTS AND METHODS: A retrospective analysis of 75 tumors in 73 patients treated with carbon ion radiotherapy was performed. There were 26 spinal, 38 pelvic, and 11 other types of tumors. Seventy conventional and five dedifferentiated chondrosarcomas were treated in 69 and four patients, respectively...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29121984/carbon-ion-radiotherapy-impact-of-tumor-differentiation-on-local-control-in-experimental-prostate-carcinomas
#16
Christin Glowa, Peter Peschke, Stephan Brons, Oliver C Neels, Klaus Kopka, Jürgen Debus, Christian P Karger
BACKGROUND: To summarize the research activities of the "clinical research group heavy ion therapy", funded by the German Research Foundation (DFG, KFO 214), on the impact of intrinsic tumor characteristics (grading, hypoxia) on local tumor control after carbon ((12)C-) ion- and photon irradiations. METHODS: Three sublines of syngeneic rat prostate tumors (R3327) with various differentiation levels (highly (-H), moderately (-HI) or anaplastic (-AT1), (diameter 10 mm) were irradiated with 1, 2 and 6 fractions of either (12)C-ions or 6 MV photons using increasing dose levels...
November 9, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29119856/radiological-properties-of-healthy-carcinoma-and-equivalent-breast-tissues-for-photon-and-charged-particle-interactions
#17
M Büyükyıldız, M Kurudirek
PURPOSE: In this paper, the effective atomic numbers (Zeff), electron densities (Neff), exposure buildup factor (EBF) and energy absorption buildup factor (EABF) of healthy (H), carcinoma (C) and equivalent (E) breast tissues were investigated to quantify differences in radiological parameters between the tissues in the continuous energy region. For these purposes, Zeffs and Neffs, of healthy, carcinoma and equivalent (H-C-E) breast tissues were calculated for interaction of gamma rays and charged particles with selected tissues...
November 9, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29114615/risk-of-carotid-blowout-after-reirradiation-with-particle-therapy
#18
Jon Espen Dale, Silvia Molinelli, Elisa Ciurlia, Mario Ciocca, Maria Bonora, Viviana Vitolo, Alfredo Mirandola, Stefania Russo, Roberto Orecchia, Olav Dahl, Piero Fossati
Purpose: Carotid blowout (CB) is a serious complication in retreatment of neoplasms in the head and neck (H&N) region. Rates seem to increase in hypofractionated or accelerated hyperfractionated regimens. In this study, we investigate the CB rate and the cumulative doses received by the carotid artery (CA) in a cohort of patients who were reirradiated at CNAO with particle therapy in the H&N region. Methods and materials: The dosimetric information, medical records, and tumor characteristics of 96 patients were analyzed...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29114600/abscopal-effect-in-recurrent-colorectal-cancer-treated-with-carbon-ion-radiation-therapy-2-case-reports
#19
Daniel K Ebner, Tadashi Kamada, Shigeru Yamada
No abstract text is available yet for this article.
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29100701/robustness-of-patient-positioning-for-interfractional-error-in-carbon-ion-radiotherapy-for-stage-i-lung-cancer-bone-matching-versus-tumor-matching
#20
Makoto Sakai, Yoshiki Kubota, Jun-Ichi Saitoh, Daisuke Irie, Katsuyuki Shirai, Ryosuke Okada, Masami Torikoshi, Tatsuya Ohno, Takashi Nakano
BACKGROUND AND PURPOSE: Patient positioning was compared by tumor matching (TM) and conventional bony structure matching (BM) in carbon ion radiotherapy for stage I non-small cell lung cancer to evaluate the robustness of TM and BM in determining interfractional error. MATERIAL AND METHODS: Sixty irradiation fields were analyzed. Computed tomography (CT) images acquired before treatment initiation for confirmation (Conf-CT) were obtained under the same settings as the treatment planning CT images and used to evaluate both positioning methods...
October 31, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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