keyword
MENU ▼
Read by QxMD icon Read
search

Heavy ion therapy

keyword
https://www.readbyqxmd.com/read/29139207/patient-reported-outcomes-of-slow-single-arc-rotation-do-we-need-rotating-gantries
#1
Brendan Whelan, Miriam Welgampola, Leigh McGarvie, Kuldeep Makhija, Robin M Turner, Lois Holloway, Ilana Feain, Michael Jackson, Michael Barton, Paul Keall
INTRODUCTION: Patient rotation could greatly simplify radiation therapy delivery, with particularly important ramifications for fixed beam treatment with protons, heavy ions, MRI-Linacs, and low cost Linacs. Patient tolerance is often cited as a barrier to widespread implementation to patient rotation; however, no quantitative data addressing this issue exists. In this study, patient reported experiences of slow, single arc rotation in upright (sitting) and lying orientations are reported...
November 15, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29121984/carbon-ion-radiotherapy-impact-of-tumor-differentiation-on-local-control-in-experimental-prostate-carcinomas
#2
Christin Glowa, Peter Peschke, Stephan Brons, Oliver C Neels, Klaus Kopka, Jürgen Debus, Christian P Karger
BACKGROUND: To summarize the research activities of the "clinical research group heavy ion therapy", funded by the German Research Foundation (DFG, KFO 214), on the impact of intrinsic tumor characteristics (grading, hypoxia) on local tumor control after carbon ((12)C-) ion- and photon irradiations. METHODS: Three sublines of syngeneic rat prostate tumors (R3327) with various differentiation levels (highly (-H), moderately (-HI) or anaplastic (-AT1), (diameter 10 mm) were irradiated with 1, 2 and 6 fractions of either (12)C-ions or 6 MV photons using increasing dose levels...
November 9, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29092716/the-150-most-important-questions-in-cancer-research-and-clinical-oncology-series-questions-67-75-edited-by-chinese-journal-of-cancer
#3
EDITORIAL
(no author information available yet)
Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology, which sparkle diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. In this article, 9 more questions are presented as followed. Question 67. How could we overcome the resistance of hepatocellular carcinoma against chemotherapeutics? Question 68. Is pursuit of non-covalent small-molecule binders of RAS proteins viable as a strategy of cancer drug discovery? Question 69...
November 1, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29069515/microdosimetric-applications-in-proton-and-heavy-ion-therapy-using-silicon-microdosimeters
#4
L Chartier, L T Tran, D Bolst, S Guatelli, A Pogossov, D A Prokopovich, M I Reinhard, V Perevertaylo, S Anderson, C Beltran, N Matsufuji, M Jackson, A B Rosenfeld
Using the CMRP 'bridge' μ+ probe, microdosimetric measurements were undertaken out-of-field using a therapeutic scanning proton pencil beam and in-field using a 12 C ion therapy field. These measurements were undertaken at Mayo Clinic, Rochester, USA and at HIMAC, Chiba, Japan, respectively. For a typical proton field used in the treatment of deep-seated tumors, we observed dose-equivalent values ranging from 0.62 to 0.99 mSv/Gy at locations downstream of the distal edge. Lateral measurements at depths close to the entrance and along the SOBP plateau were found to reach maximum values of 3...
October 21, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29053152/heart-in-space-effect-of-the-extraterrestrial-environment-on-the-cardiovascular-system
#5
REVIEW
Richard L Hughson, Alexander Helm, Marco Durante
National space agencies and private corporations aim at an extended presence of humans in space in the medium to long term. Together with currently suboptimal technology, microgravity and cosmic rays raise health concerns about deep-space exploration missions. Both of these physical factors affect the cardiovascular system, whose gravity-dependence is pronounced. Heart and vascular function are, therefore, susceptible to substantial changes in weightlessness. The altered cardiovascular function in space causes physiological problems in the postflight period...
October 20, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/29034910/from-boron-clusters-to-gold-clusters-new-label-free-colorimetric-sensors
#6
Bin Qi, Chenchen Wu, Ling Xu, Wenjing Wang, Jin Cao, Jun Liu, Shuai Zhang, Detlef Gabel, Haibo Zhang, Xiaohai Zhou
A fundamental boron cluster, [closo-B12H12](2-), mainly known as an inert agent for boron neutron capture therapy, can also serve as a bi-functional reductant and a capping agent for the formation of monodispersed size-controlled gold nanoparticles (AuNPs) under mild reaction conditions. The obtained AuNPs remained thermo-dynamically stable over 3 months, and exhibited high performance in phase transfer and sensing of heavy metal ions.
August 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28929085/the-potential-of-heavy-ion-therapy-to-improve-outcomes-for-locally-advanced-non-small-cell-lung-cancer
#7
Stephen G Chun, Timothy D Solberg, David R Grosshans, Quynh-Nhu Nguyen, Charles B Simone, Radhe Mohan, Zhongxing Liao, Stephen M Hahn, Joseph M Herman, Steven J Frank
No abstract text is available yet for this article.
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28910671/delayed-effects-of-accelerated-heavy-ions-on-the-induction-of-hprt-mutations-in-v79-hamster-cells
#8
Pavel Bláha, Nataliya A Koshlan, Igor V Koshlan, Daria V Petrova, Yulia V Bogdanova, Raisa D Govorun, Viliam Múčka, Evgeny A Krasavin
Fundamental research on the harmful effects of ionizing radiation on living cells continues to be of great interest. Recently, priority has been given to the study of high-charge and high-energy (HZE) ions that comprise a substantial part of the galactic cosmic ray (GCR) spectra that would be encountered during long-term space flights. Moreover, predictions of the delayed genetic effects of high linear energy transfer (LET) exposure is becoming more important as heavy ion therapy use is increasing. This work focuses mainly on the basic research on the delayed effects of HZE ions on V79 Chinese hamster cells, with emphasis on the induction of HPRT mutations after prolonged expression times (ET)...
October 2017: Mutation Research
https://www.readbyqxmd.com/read/28832343/a-new-formalism-for-modelling-parameters-%C3%AE-and-%C3%AE-of-the-linear-quadratic-model-of-cell-survival-for-hadron-therapy
#9
Oleg N Vassiliev, David R Grosshans, Radhe Mohan
We propose a new formalism for calculating parameters α and β of the linear quadratic model of cell survival. This formalism, primarily intended for calculating relative biological effectiveness (RBE) for treatment planning in hadron therapy, is based on a recently proposed microdosimetric revision of the single-target multi-hit model. The main advantage of our formalism is that it reliably produces α and β that have correct general properties with respect to their dependence on physical properties of the beam, including the asymptotic behavior for very low and high linear energy transfer (LET) beams...
August 23, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28714067/technical-note-evaluation-of-plastic-scintillator-detector-for-small-field-stereotactic-patient-specific-quality-assurance
#10
Yujiao Qin, Stephen J Gardner, Joshua Kim, Yimei Huang, Ning Wen, Anthony Doemer, Indrin J Chetty
PURPOSE: To evaluate the performance of a commercial plastic scintillator detector (PSD) for small-field stereotactic patient-specific quality assurance (QA) measurements using flattening-filter-free beam. METHODS: A total of 10 spherical targets [volume range: (0.03 cc-2 cc)] were planned with two techniques: (a) dynamic conformal arc (DCA-10 plans) and (b) volumetric modulated arc therapy (VMAT-10 plans). All plans were generated using Varian Eclipse treatment planning system, and AcurosXB v...
October 2017: Medical Physics
https://www.readbyqxmd.com/read/28650058/dynamically-tuning-near-infrared-induced-photothermal-performances-of-tio2-nanocrystals-by-nb-doping-for-imaging-guided-photothermal-therapy-of-tumors
#11
Nuo Yu, Yong Hu, Xiaoyong Wang, Gang Liu, Zhaojie Wang, Zixiao Liu, Qiwei Tian, Meifang Zhu, Xiangyang Shi, Zhigang Chen
Conventional wide bandgap semiconductors can absorb UV/visible light but have no photoabsorption band in the near-infrared (NIR) region, leading to difficulty in their use as NIR-responsive agents. With TiO2 as an example, we report the tuning from UV-responsive TiO2 nanocrystals to blue TiO2 nanocrystals with newly appeared NIR absorption band through the Nb-doping strategy. A strong NIR band should result from the localized surface plasmon resonances due to the considerable free electrons originating from the efficient incorporation of Nb(5+) ions (<15...
July 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/28599495/investigation-of-the-relative-biological-effectiveness-and-uniform-isobiological-killing-effects-of-irradiation-with-a-clinical-carbon-sobp-beam-on-dna-repair-deficient-cho-cells
#12
Shigeaki Sunada, Ian M Cartwright, Hirokazu Hirakawa, Akira Fujimori, Mitsuru Uesaka, Takamitsu A Kato
Spread-out Bragg peak (SOBP) C ions have been used clinically in charged particle radiation therapy for years. An SOBP beam consists of various monoenergetic Bragg peaks; however, the biological effect of irradiation with an SOBP beam track has not been well-studied. In order to determine the clinically prospective molecular targets, radiosensitivity to the beam track in DNA repair deficient cell lines was investigated. A total of four distinct Chinese hamster ovary (CHO) cell lines, including CHO10B2 (wild-type), V3 (protein kinase DNA-activated catalytic polypeptide deficient), 51D1 (RAD51 paralog D deficient) and PADR9 [poly(ADP-ribose) polymerase (PARP) deficient], were irradiated with gamma-rays, C ions (290 MeV/n) and Fe ions (500 MeV/n), in order to compare cellular lethality...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28594467/biochemical-characterization-of-lr769-a-new-recombinant-factor-viia-bypassing-agent-produced-in-the-milk-of-transgenic-rabbits
#13
G Chevreux, N Tilly, Y Leblanc, C Ramon, V Faid, M Martin, F Dhainaut, N Bihoreau
BACKGROUND: The bypassing agent factor VII (FVIIa) is a first-line therapy for the treatment of acute bleeding episodes in patients with haemophilia and high-titre inhibitors. FVIIa is a highly post-translationally modified protein that requires eukaryotic expression systems to produce a fully active molecule. A recombinant FVIIa was produced in the milk of transgenic rabbits to increase expression and provide an efficient, safe and affordable product after purification to homogeneity (LR769)...
June 8, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28586136/benchmarking-geant4-hadronic-models-for-prompt-%C3%AE-monitoring-in-carbon-ion%C3%A2-therapy
#14
Marie Vanstalle, Ilaria Mattei, Alessio Sarti, Fabio Bellini, Fabiano Bini, Francesco Collamati, Erika De Lucia, Marco Durante, Riccardo Faccini, Fernando Ferroni, Christian Finck, Salvatore Fiore, Michela Marafini, Vincenzo Patera, Luca Piersanti, Marta Rovituso, Christoph Schuy, Adalberto Sciubba, Giacomo Traini, Cecilia Voena, Chiara La Tessa
PURPOSE: The real-time monitoring of the spread-out Bragg peak would allow the planned dose delivered during treatment to be directly verified, but this poses a major challenge in modern ion beam therapy. A possible method to achieve this goal is to exploit the production of secondary particles by the nuclear reactions of the beam with the patient and correlate their emission profile to the planned target volume position. In this study, we present both the production rate and energy spectra of the prompt-γ produced by the interactions of the (12) C ion beam with a polymethyl methacrylate (PMMA) target...
August 2017: Medical Physics
https://www.readbyqxmd.com/read/28557800/lateral-variations-of-radiobiological-properties-of-therapeutic-fields-of-sup-1-sup-h-sup-4-sup-he-sup-12-sup-c-and-sup-16-sup-o-ions-studied-with-geant4-and-microdosimetric-kinetic-model
#15
Sophie Dewey, Lucas Burigo, Igor A Pshenichnov, Igor Mishustin, Marcus Bleicher
As known, in cancer therapy with ion beams the relative biological effectiveness (RBE) of ions changes in the course of their propagation in tissues. Such changes are caused not only by increasing the linear energy transfer (LET) of beam particles with the penetration depth towards the Bragg peak, but also by nuclear reactions induced by beam nuclei leading to the production of various secondary particles. Although the changes of RBE along the beam axis have been studied quite well, much less attention has been paid to the evolution of RBE in the transverse direction, perpendicular to the beam axis...
May 30, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28554507/track-structure-model-of-microscopic-energy-deposition-by-protons-and-heavy-ions-in-segments-of-neuronal-cell-dendrites-represented-by-cylinders-or-spheres
#16
Murat Alp, Francis A Cucinotta
Changes to cognition, including memory, following radiation exposure are a concern for cosmic ray exposures to astronauts and in Hadron therapy with proton and heavy ion beams. The purpose of the present work is to develop computational methods to evaluate microscopic energy deposition (ED) in volumes representative of neuron cell structures, including segments of dendrites and spines, using a stochastic track structure model. A challenge for biophysical models of neuronal damage is the large sizes (> 100µm) and variability in volumes of possible dendritic segments and pre-synaptic elements (spines and filopodia)...
May 2017: Life Sciences in Space Research
https://www.readbyqxmd.com/read/28471199/-zinc-modified-nanotransporter-for-target-drug-therapy-of-breast-cancer
#17
S Skaličková, M Gargulák, M Löffelmann, B Ruttkay-Nedecký, M Kepinská, T Parák, R Kizek
BACKGROUND: In the centre of nanomedical interest stands the nanotechnological modification of anthracycline antibiotics, which are often used in antitumor treatment of hematological malignancies and solid tumors. Chitosan nanoparticles are gaining more attention in the field of targeted transport of drugs because of their stability, low toxicity and simple preparation. The main objective of the project, was the design of chitosan nanotransporter of anthracycline antibiotics with zinc modified surface, for a specific interaction with metallothionein...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28348976/combination-of-photon-and-carbon-ion-irradiation-with-targeted-therapy-substances-temsirolimus-and-gemcitabine-in-hepatocellular-carcinoma-cell-lines
#18
Sarah Dehne, Clarissa Fritz, Stefan Rieken, Daniela Baris, Stephan Brons, Thomas Haberer, Jürgen Debus, Klaus-Josef Weber, Thomas E Schmid, Stephanie E Combs, Daniel Habermehl
BACKGROUND: This work investigates on putative cytotoxic effects in four different hepatocellular carcinoma (HCC) cell lines after irradiation with photons or carbon ions in combination with new targeted molecular therapy using either Temsirolimus (TEM) or Gemcitabine (GEM). METHODS AND MATERIALS: The HCC cell lines HepG2, Hep3B, HuH7, and PLC were cultured and irradiated with photons or carbon ions at the Heidelberg Ion Beam Therapy Center using the raster-scanning method...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28339049/kidney-and-heavy-metals-the-role-of-environmental-exposure-review
#19
Paolo Lentini, Luca Zanoli, Antonio Granata, Salvatore Santo Signorelli, Pietro Castellino, Roberto Dell'Aquila
Heavy metals are extensively used in agriculture and industrial applications such as production of pesticides, batteries, alloys, and textile dyes. Prolonged, intensive or excessive exposure can induce related systemic disorders. Kidney is a target organ in heavy metal toxicity for its capacity to filter, reabsorb and concentrate divalent ions. The extent and the expression of renal damage depends on the species of metals, the dose, and the time of exposure. Almost always acute kidney impairment differs from chronic renal failure in its mechanism and in the magnitude of the outcomes...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28275377/impact-of-particle-irradiation-on-the-immune-system-from-the-clinic-to-mars
#20
REVIEW
Rodrigo Fernandez-Gonzalo, Sarah Baatout, Marjan Moreels
Despite the generalized use of photon-based radiation (i.e., gamma rays and X-rays) to treat different cancer types, particle radiotherapy (i.e., protons and carbon ions) is becoming a popular, and more effective tool to treat specific tumors due to the improved physical properties and biological effectiveness. Current scientific evidence indicates that conventional radiation therapy affects the tumor immunological profile in a particular manner, which in turn, might induce beneficial effects both at local and systemic (i...
2017: Frontiers in Immunology
keyword
keyword
54246
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"