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Heavy ion therapy

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https://www.readbyqxmd.com/read/27885084/analysis-of-neutron-production-in-passively-scattered-ion-beam-therapy
#1
Seunguk Heo, Seunghoon Yoo, Yongkeun Song, Eunho Kim, Jaeik Shin, Soorim Han, Wongyun Jung, Sanghee Nam, Rena Lee, Kitae Lee, Sungho Cho
A new treatment facility for heavy ion therapy since 2010 was constructed. In the broad beam, a range shifter, ridge filter and multi leaf collimator (MLC) for the generation of the spread-out Bragg peak is used. In this case, secondary neutrons produced by the interactions of the ion field with beam-modifying devices (e.g. double-scattering system, beam shaping collimators and range compensators) are very important for patient safety. Therefore, these components must be carefully examined in the context of secondary neutron yield and associated secondary cancer risk...
November 24, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27884156/targeted-myocardial-gene-expression-in-failing-hearts-by-rna-sequencing
#2
Kajari Dhar, Alexandra M Moulton, Eric Rome, Fang Qiu, Jeff Kittrell, Eugenia Raichlin, Ronald Zolty, John Y Um, Michael J Moulton, Hesham Basma, Daniel R Anderson, James D Eudy, Brian D Lowes
BACKGROUND: Myocardial recovery with left ventricular assist device (LVAD) therapy is highly variable and difficult to predict. Next generation ribonucleic acid (RNA) sequencing is an innovative, rapid, and quantitative approach to gene expression profiling in small amounts of tissue. Our primary goal was to identify baseline transcriptional profiles in non-ischemic cardiomyopathies that predict myocardial recovery in response to LVAD therapy. We also sought to verify transcriptional differences between failing and non-failing human hearts...
November 25, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27869095/does-heavy-ion-therapy-work-through-the-immune-system
#3
Marco Durante, David J Brenner, Silvia C Formenti
No abstract text is available yet for this article.
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27853089/disseminated-mycobacterium-tuberculosis-infection-masquerading-as-metastasis-after-heavy-ion-radiotherapy-for-prostate-cancer
#4
Masaru Ando, Yutaka Mukai, Ryo-Ichi Ushijima, Yoshiyuki Shioyama, Kenji Umeki, Fumito Okada, Shin-Ichi Nureki, Hiromitsu Mimata, Jun-Ichi Kadota
Fluorodeoxyglucose (FDG)-positron emission tomography with computed tomography (FDG-PET/CT) is useful in disease monitoring of malignancies after therapy, while an FDG uptake may also be present in benign diseases. We herein demonstrate a case of disseminated Mycobacterium tuberculosis mimicking systemic metastasis of prostate cancer. This case highlights that clinicians should consider Mycobacterium tuberculosis in patients with prostate cancer who demonstrate multifocal FDG uptakes masquerading as metastasis, even when the chest photographs reveal a normal appearance and a sputum examination demonstrates negative results...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27845937/effectiveness-of-respiratory-gated-radiotherapy-with-audio-visual-biofeedback-for-synchrotron-based-scanned-heavy-ion-beam-delivery
#5
Pengbo He, Qiang Li, Ting Zhao, Xinguo Liu, Zhongying Dai, Yuanyuan Ma
A synchrotron-based heavy-ion accelerator operates in pulse mode at a low repetition rate that is comparable to a patient's breathing rate. To overcome inefficiencies and interplay effects between the residual motion of the target and the scanned heavy-ion beam delivery process for conventional free breathing (FB)-based gating therapy, a novel respiratory guidance method was developed to help patients synchronize their breathing patterns with the synchrotron excitation patterns by performing short breath holds with the aid of personalized audio-visual biofeedback (BFB) system...
December 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27836119/a-multi-institutional-analysis-of-prospective-studies-of-carbon-ion-radiotherapy-for-prostate-cancer-a-report-from-the-japan-carbon-ion-radiation-oncology-study-group-j-cros
#6
Takuma Nomiya, Hiroshi Tsuji, Hidemasa Kawamura, Tatsuya Ohno, Shingo Toyama, Yoshiyuki Shioyama, Yuko Nakayama, Kenji Nemoto, Hirohiko Tsujii, Tadashi Kamada
BACKGROUND AND PURPOSE: A multi-institutional observational study (J-CROS1501PR) has been carried out to analyze outcomes of carbon-ion radiotherapy (CIRT) for patients with prostate cancer. PATIENTS AND METHODS: Data of the patients enrolled in prospective studies of following 3 CIRT institutions were analyzed: National Institute of Radiological Sciences (NIRS; Chiba, Japan), Gunma University Heavy Ion Medical Center (GHMC; Gunma, Japan), and Ion Beam Therapy Center, SAGA HIMAT Foundation (HIMAT; Saga, Japan)...
November 8, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27806584/triple-ionization-chamber-method-for-clinical-dose-monitoring-with-a-be-covered-li-bnct-field
#7
Thanh Tat Nguyen, Tsuyoshi Kajimoto, Kenichi Tanaka, Chien Cong Nguyen, Satoru Endo
PURPOSE: Fast neutron, gamma-ray, and boron doses have different relative biological effectiveness (RBE). In boron neutron capture therapy (BNCT), the clinical dose is the total of these dose components multiplied by their RBE. Clinical dose monitoring is necessary for quality assurance of the irradiation profile; therefore, the fast neutron, gamma-ray, and boron doses should be separately monitored. To estimate these doses separately, and to monitor the boron dose without monitoring the thermal neutron fluence, the authors propose a triple ionization chamber method using graphite-walled carbon dioxide gas (C-CO2), tissue-equivalent plastic-walled tissue-equivalent gas (TE-TE), and boron-loaded tissue-equivalent plastic-walled tissue-equivalent gas [TE(B)-TE] chambers...
November 2016: Medical Physics
https://www.readbyqxmd.com/read/27782720/a-general-algorithm-for-calculation-of-recombination-losses-in-ionization-chambers-exposed-to-ion-beams
#8
Jeppe Brage Christensen, Heikki Tölli, Niels Bassler
PURPOSE: Dosimetry with ionization chambers in clinical ion beams for radiation therapy requires correction for recombination effects. However, common radiation protocols discriminate between initial and general recombination and provide no universal correction method for the presence of both recombination types in ion beams of charged particles heavier than protons. The advent of multiple field optimization in ion beams, allowing for complex patterns of dose delivery in both temporal and spatial domains, results in new challenges for recombination correction where the resulting recombination depends on the plan delivered...
October 2016: Medical Physics
https://www.readbyqxmd.com/read/27770265/hadrontherapy-from-the-italian-radiation-oncologist-point-of-view-face-the-reality-the-italian-society-of-oncological-radiotherapy-airo-survey
#9
Giulia Marvaso, Barbara Vischioni, Barbara Alicja Jereczek-Fossa, Delia Ciardo, Piero Fossati, Tommaso Giandini, Sara Morlino, Mauro Carrara, Paola Romanelli, Elvio Russi, Francesca Valvo, Riccardo Valdagni, Roberto Orecchia
Hadrontherapy has been in constant progress in the past decades. Due to the increasing interest in this field and the spreading of the technique in Italy and worldwide, the Italian Society of Radiation Oncology surveyed (by an online survey) its members regarding their perception of hadrontherapy. The survey outline addressed different items all related to hadrontherapy, such as: demographics (3 items), personal knowledge (5 items), actual use in clinical practice (5 items), and future perspectives and development (5 items)...
October 21, 2016: La Radiologia Medica
https://www.readbyqxmd.com/read/27726113/late-sacral-recurrence-of-rectal-cancer-treated-by-heavy-ion-radiotherapy-a-case-report
#10
Hiroyuki Matsuzaki, Soichiro Ishihara, Kazushige Kawai, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Hiroaki Nozawa, Shigeru Yamada, Toshiaki Watanabe
BACKGROUND: The need for surveillance of rare late recurrence of rectal cancer has not yet been established. Local control of unresectable skeletal metastasis is important for palliation of symptoms and support for systemic chemotherapy. CASE PRESENTATION: A Japanese man underwent preoperative pelvic irradiation (50.4 Gy/28 Fr) and low anterior resection at the age of 57 years. The pathological stage was II (T3N0M0). Nine years after the surgery, his carcinoembryonic antigen (CEA) level showed rapid elevation, although he had no symptoms...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27675134/optimized-strategy-for-multimodality-treatment-planning-of-single-beam-heavy-ion-therapy-plus-photon-intensity-modulated-radiation-therapy-exemplified-by-pelvic-bone-sarcomas
#11
C Schuppert, A Mohr, A Schwahofer, S Nill, J Debus, F Sterzing
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27659746/-analysis-of-the-2015%C3%A2-british-guidelines-on-the-prevention-and-management-of-tumor-lysis-syndrome
#12
A Dupré, C Mousseaux, A Bouguerba, S Ayed, J Barchazs, M Boukari, D Goldgran-Toledano, C Bornstain, F Vincent
Whether it appears spontaneously or is induced by therapy, the tumor lysis syndrome is responsible for a massive release of ions and puric bases degradation of products in the circulation exceeding the renal excretion capacity. Some, such as uric acid, xanthine, and calcium phosphate, can precipitate in the renal tubules or parenchyma. It must be known to any practitioner supporting patients with hematologic malignancies, mainly high-grade but also some solid tumors. The 2015 publication of the British recommendations pertaining to patients suffering from hematological diseases should be broadcast...
September 19, 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/27659007/review-of-geant4-dna-applications-for-micro-and-nanoscale-simulations
#13
S Incerti, M Douglass, S Penfold, S Guatelli, E Bezak
Emerging radiotherapy treatments including targeted particle therapy, hadron therapy or radiosensitisation of cells by high-Z nanoparticles demand the theoretical determination of radiation track structure at the nanoscale. This is essential in order to evaluate radiation damage at the cellular and DNA level. Since 2007, Geant4 offers physics models to describe particle interactions in liquid water at the nanometre level through the Geant4-DNA Package. This package currently provides a complete set of models describing the event-by-event electromagnetic interactions of particles with liquid water, as well as developments for the modelling of water radiolysis...
September 19, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27541302/heavy-ions-in-cancer-therapy
#14
Arnold Pompos, Marco Durante, Hak Choy
No abstract text is available yet for this article.
August 18, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27455642/the-radiation-enhancement-of-15-nm-citrate-capped-gold-nanoparticles-exposed-to-70-kev-%C3%AE-m-carbon-ions
#15
Yan Liu, Xi Liu, Xiaodong Jin, Pengbo He, Xiaogang Zheng, Fei Ye, Weiqiang Chen, Qiang Li
Radiotherapy is an important modality for tumor treatment. The central goal of radiotherapy is to deliver a therapeutic dose to the tumor as much as possible whilst sparing the surrounding normal tissues. On one hand, heavy ion radiation induces maximum damage at the end of the track (called the Bragg Peak). Hadron therapy based on heavy ions is considered superior to conventional X-rays and γ-rays radiations for tumors sited in sensitive tissues, childhood cases and radioresistant cancers. On the other hand, radiation sensitizers enhanced the radiation effects in tumors by increasing the dose specifically to the tumor cells...
March 2016: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/27380803/dependence-and-independence-of-survival-parameters-on-linear-energy-transfer-in-cells-and-tissues
#16
Koichi Ando, Dudley T Goodhead
Carbon-ion radiotherapy has been used to treat more than 9000 cancer patients in the world since 1994. Spreading of the Bragg peak is necessary for carbon-ion radiotherapy, and is designed based on the linear-quadratic model that is commonly used for photon therapy. Our recent analysis using in vitro cell kills and in vivo mouse tissue reaction indicates that radiation quality affects mainly the alpha terms, but much less the beta terms, which raises the question of whether this is true in other biological systems...
July 5, 2016: Journal of Radiation Research
https://www.readbyqxmd.com/read/27376029/translational-research-to-improve-the-efficacy-of-carbon-ion-radiotherapy-experience-of-gunma-university
#17
REVIEW
Takahiro Oike, Hiro Sato, Shin-Ei Noda, Takashi Nakano
Carbon ion radiotherapy holds great promise for cancer therapy. Clinical data show that carbon ion radiotherapy is an effective treatment for tumors that are resistant to X-ray radiotherapy. Since 1994 in Japan, the National Institute of Radiological Sciences has been heading the development of carbon ion radiotherapy using the Heavy Ion Medical Accelerator in Chiba. The Gunma University Heavy Ion Medical Center (GHMC) was established in the year 2006 as a proof-of-principle institute for carbon ion radiotherapy with a view to facilitating the worldwide spread of compact accelerator systems...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27376024/short-dna-fragments-are-a-hallmark-of-heavy-charged-particle-irradiation-and-may-underlie-their-greater-therapeutic-efficacy
#18
Dalong Pang, Sergey Chasovskikh, James E Rodgers, Anatoly Dritschilo
Growing interest in proton and heavy ion therapy has reinvigorated research into the fundamental biological mechanisms underlying the therapeutic efficacy of charged-particle radiation. To improve our understanding of the greater biological effectiveness of high-LET radiations, we have investigated DNA double-strand breaks (DSBs) following exposure of plasmid DNA to low-LET Co-60 gamma photon and electron irradiation and to high-LET Beryllium and Argon ions with atomic force microscopy. The sizes of DNA fragments following radiation exposure were individually measured to construct fragment size distributions from which the DSB per DNA molecule and DSB spatial distributions were derived...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27335791/the-initial-case-report-salvage-robotic-assisted-radical-prostatectomy-after-heavy-ion-radiotherapy
#19
Choichiro Ozu, Keisuke Aoki, Ken Nakamura, Yasuto Yagi, Yusuke Muro, Toru Nishiyama, Yuho Kono, Kunihiko Yoshioka, Hiroshi Tsuji, Arafumi Maeshima, Shiro Saito
Salvage radical prostatectomy is one of treatments after radiation therapy to patients with prostate cancer. To date, no case of the salvage robotic assisted radical prostatectomy (RARP) following heavy ion radiotherapy (HIRT) has been published. We report on a 70-year-old man with a history of HIRT for prostate cancer in 2011. For 3 years after. HIRT, his serum PSA levels were permissible range. However, his PSA levels were increased. We had diagnosis localized prostate cancer after HIRT. We had carried out salvage RARP...
July 2016: Urology Case Reports
https://www.readbyqxmd.com/read/27257076/chromosome-thripsis-by-dna-double-strand-break-clusters-causes-enhanced-cell-lethality-chromosomal-translocations-and-53bp1-recruitment
#20
Agnes Schipler, Veronika Mladenova, Aashish Soni, Vladimir Nikolov, Janapriya Saha, Emil Mladenov, George Iliakis
Chromosome translocations are hallmark of cancer and of radiation-induced cell killing, reflecting joining of incongruent DNA-ends that alter the genome. Translocation-formation requires DNA end-joining mechanisms and incompletely characterized, permissive chromatin conditions. We show that chromatin destabilization by clusters of DNA double-strand-breaks (DSBs) generated by the I-SceI meganuclease at multiple, appropriately engineered genomic sites, compromises c-NHEJ and markedly increases cell killing and translocation-formation compared to single-DSBs...
September 19, 2016: Nucleic Acids Research
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