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Heavy ion therapy

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https://www.readbyqxmd.com/read/28471199/-zinc-modified-nanotransporter-for-target-drug-therapy-of-breast-cancer
#1
S Skaličková, M Gargulák, M Löffelmann, B Ruttkay-Nedecký, M Kepinská, T Parák, R Kizek
BACKGROUND: In the centre of nanomedical interest stands the nanotechnological modification of anthracycline antibiotics, which are often used in antitumor treatment of hematological malignancies and solid tumors. Chitosan nanoparticles are gaining more attention in the field of targeted transport of drugs because of their stability, low toxicity and simple preparation. The main objective of the project, was the design of chitosan nanotransporter of anthracycline antibiotics with zinc modified surface, for a specific interaction with metallothionein...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28348976/combination-of-photon-and-carbon-ion-irradiation-with-targeted-therapy-substances-temsirolimus-and-gemcitabine-in-hepatocellular-carcinoma-cell-lines
#2
Sarah Dehne, Clarissa Fritz, Stefan Rieken, Daniela Baris, Stephan Brons, Thomas Haberer, Jürgen Debus, Klaus-Josef Weber, Thomas E Schmid, Stephanie E Combs, Daniel Habermehl
BACKGROUND: This work investigates on putative cytotoxic effects in four different hepatocellular carcinoma (HCC) cell lines after irradiation with photons or carbon ions in combination with new targeted molecular therapy using either Temsirolimus (TEM) or Gemcitabine (GEM). METHODS AND MATERIALS: The HCC cell lines HepG2, Hep3B, HuH7, and PLC were cultured and irradiated with photons or carbon ions at the Heidelberg Ion Beam Therapy Center using the raster-scanning method...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28339049/kidney-and-heavy-metals-the-role-of-environmental-exposure-review
#3
Paolo Lentini, Luca Zanoli, Antonio Granata, Salvatore Santo Signorelli, Pietro Castellino, Roberto Dell'Aquila
Heavy metals are extensively used in agriculture and industrial applications such as production of pesticides, batteries, alloys, and textile dyes. Prolonged, intensive or excessive exposure can induce related systemic disorders. Kidney is a target organ in heavy metal toxicity for its capacity to filter, reabsorb and concentrate divalent ions. The extent and the expression of renal damage depends on the species of metals, the dose, and the time of exposure. Almost always acute kidney impairment differs from chronic renal failure in its mechanism and in the magnitude of the outcomes...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28275377/impact-of-particle-irradiation-on-the-immune-system-from-the-clinic-to-mars
#4
REVIEW
Rodrigo Fernandez-Gonzalo, Sarah Baatout, Marjan Moreels
Despite the generalized use of photon-based radiation (i.e., gamma rays and X-rays) to treat different cancer types, particle radiotherapy (i.e., protons and carbon ions) is becoming a popular, and more effective tool to treat specific tumors due to the improved physical properties and biological effectiveness. Current scientific evidence indicates that conventional radiation therapy affects the tumor immunological profile in a particular manner, which in turn, might induce beneficial effects both at local and systemic (i...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28252435/-genomic-variability-in-patients-with-ductal-form-of-breast-cancer-and-the-possibility-of-correction-the-peptide-bioregulator-and-metal-ions
#5
T Jokhadze, J Monaselidze, G Nemsadze, T Buadze, M Gaiozishvili, T Lezhava
Level of genome stability (structural aberrations, aneuploidy and fragile sites) was studied in cells of the lymphocyte culture of ductal breast cancer patients (DBC). Was studied the correctional influence of separate and combinative action of peptide bioregulator (Ala-Glu-Asp-Gly) and heavy metal - nickel. It is shown that DBC patients are characterized by high level of genome instability, which is the result of the chromatin changing state. The used tests makes it possible to conclude that in the case of this form of cancer subordinates to specific epigenetic variation as a hetero- also euchromatic regions of genome...
January 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28214420/prevention-of-radiotherapy-induced-neurocognitive-dysfunction-in-survivors-of-paediatric-brain-tumours-the-potential-role-of-modern-imaging-and-radiotherapy-techniques
#6
REVIEW
Thankamma Ajithkumar, Stephen Price, Gail Horan, Amos Burke, Sarah Jefferies
Neurocognitive dysfunction is the leading cause of reduced quality of life in long-term survivors of paediatric brain tumours. Radiotherapy is one of the main contributors to neurocognitive sequelae. Current approaches for prevention and reduction of neurocognitive dysfunction include avoidance of radiotherapy in young children and reduction of the radiotherapy dose and volume of brain irradiated. Substantial advances have been made in brain imaging, especially with functional imaging and fibre tracking with the use of diffusion tensor imaging...
February 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28183656/facile-synthesis-of-carbon-dot-and-residual-carbon-nanobeads-implications-for-ion-sensing-medicinal-and-biological-applications
#7
Rohit Ranganathan Gaddam, Sudip Mukherjee, Neelambaram Punugupati, D Vasudevan, Chitta Ranjan Patra, Ramanuj Narayan, Raju Vsn Kothapalli
Synthesis of carbon dots (Cdots) via chemical route involves disintegration of carbon materials into nano-domains, wherein, after extraction of Cdots, the remaining carbon material is discarded. The present work focuses on studying even the leftover carbon residue namely, carbon nanobeads (CNBs) as an equally important material for applications on par with that of carbon dot. It employs oxidative treatment of carbonised gum olibanum resin (GOR) to produce the carbons namely Cdots and CNBs (as the residue). The Cdots (~5-10nm) exhibit blue-green fluorescence with an optical absorption at ~300nm unlike the CNBs (40-50nm) which fail to exhibit fluorescence...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28151733/correction-factors-to-convert-microdosimetry-measurements-in-silicon-to-tissue-in-12-c-ion-therapy
#8
David Bolst, Susanna Guatelli, Linh T Tran, Lachlan Chartier, Michael L F Lerch, Naruhiro Matsufuji, Anatoly B Rosenfeld
Silicon microdosimetry is a promising technology for heavy ion therapy (HIT) quality assurance, because of its sub-mm spatial resolution and capability to determine radiation effects at a cellular level in a mixed radiation field. A drawback of silicon is not being tissue-equivalent, thus the need to convert the detector response obtained in silicon to tissue. This paper presents a method for converting silicon microdosimetric spectra to tissue for a therapeutic (12)C beam, based on Monte Carlo simulations...
March 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28114112/secondary-radiation-measurements-for-particle-therapy-applications-prompt-photons-produced-by-4-he-12-c-and-16-o-ion-beams-in-a-pmma-target
#9
I Mattei, F Bini, F Collamati, E De Lucia, P M Frallicciardi, E Iarocci, C Mancini-Terracciano, M Marafini, S Muraro, R Paramatti, V Patera, L Piersanti, D Pinci, A Rucinski, A Russomando, A Sarti, A Sciubba, E Solfaroli Camillocci, M Toppi, G Traini, C Voena, G Battistoni
Charged particle beams are used in particle therapy (PT) to treat oncological patients due to their selective dose deposition in tissues with respect to the photons and electrons used in conventional radiotherapy. Heavy (Z  >  1) PT beams can additionally be exploited for their high biological effectiveness in killing cancer cells. Nowadays, protons and carbon ions are used in PT clinical routines. Recently, interest in the potential application of helium and oxygen beams has been growing. With respect to protons, such beams are characterized by their reduced multiple scattering inside the body, increased linear energy transfer, relative biological effectiveness and oxygen enhancement ratio...
February 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28077128/treatment-planning-comparison-of-impt-vmat-and-4%C3%AF-radiotherapy-for-prostate-cases
#10
Angelia Tran, Jingjing Zhang, Kaley Woods, Victoria Yu, Dan Nguyen, Gary Gustafson, Lane Rosen, Ke Sheng
BACKGROUND: Intensity-modulated proton therapy (IMPT), non-coplanar 4π intensity-modulated radiation therapy (IMRT), and volumetric-modulated arc therapy (VMAT) represent the most advanced treatment methods based on heavy ion and X-rays, respectively. Here we compare their performance for prostate cancer treatment. METHODS: Ten prostate patients were planned using IMPT with robustness optimization, VMAT, and 4π to an initial dose of 54 Gy to a clinical target volume (CTV) that encompassed the prostate and seminal vesicles, then a boost prescription dose of 25...
January 11, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28048551/we-fg-brb-02-spatial-mapping-of-the-rbe-of-scanned-particle-beams
#11
D Grosshans
The physical pattern of energy deposition and the enhanced relative biological effectiveness (RBE) of protons and carbon ions compared to photons offer unique and not fully understood or exploited opportunities to improve the efficacy of radiation therapy. Variations in RBE within a pristine or spread out Bragg peak and between particle types may be exploited to enhance cell killing in target regions without a corresponding increase in damage to normal tissue structures. In addition, the decreased sensitivity of hypoxic tumors to photon-based therapies may be partially overcome through the use of more densely ionizing radiations...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048194/we-fg-brb-01-clinical-significance-of-rbe-variations-in-proton-therapy
#12
H Paganetti
The physical pattern of energy deposition and the enhanced relative biological effectiveness (RBE) of protons and carbon ions compared to photons offer unique and not fully understood or exploited opportunities to improve the efficacy of radiation therapy. Variations in RBE within a pristine or spread out Bragg peak and between particle types may be exploited to enhance cell killing in target regions without a corresponding increase in damage to normal tissue structures. In addition, the decreased sensitivity of hypoxic tumors to photon-based therapies may be partially overcome through the use of more densely ionizing radiations...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048070/su-f-t-149-development-of-the-monte-carlo-simulation-platform-using-geant4-for-designing-heavy-ion-therapy-beam-nozzle
#13
Jae-Ik Shin, SeungHoon Yoo, Sungho Cho, Eun Ho Kim, Yongkeun Song, Won-Gyun Jung
PURPOSE: The significant issue of particle therapy such as proton and carbon ion was a accurate dose delivery from beam line to patient. For designing the complex delivery system, Monte Carlo simulation can be used for the simulation of various physical interaction in scatters and filters. In this report, we present the development of Monte Carlo simulation platform to help design the prototype of particle therapy nozzle and performed the Monte Carlo simulation using Geant4. Also we show the prototype design of particle therapy beam nozzle for Korea Heavy Ion Medical Accelerator (KHIMA) project in Korea Institute of Radiological and Medical Science(KIRAMS) at Republic of Korea...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047192/su-c-204-04-irradiation-of-human-cell-lines-using-various-ions
#14
Y Lin, C Tessa, A Rusek, S McMahon, T Kaminuma, K Held
PURPOSE: The purpose of this study is to investigate and quantify the biological effects of ion radiation using several human cell lines. We aim to answer the question of whether carbon ion the most ideal ion species for heavy ion radiotherapy. METHODS: The cells were irradiated at different positions along the pristine Bragg peak of several ions with different atomic number. The biological effectiveness was evaluated using the clonogenic cell survival assay. Irradiation of three human lung cancer cell lines and a fibroblast cell line were undertaken using the charged particle beam at the NASA Space Radiation Laboratory at Brookhaven National Lab...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047170/su-f-t-376-the-efficiency-of-calculating-photonuclear-reaction-on-high-energy-photon-therapy-by-monte-carlo-method
#15
S Hirayama, T Fujibuchi
PURPOSE: Secondary-neutrons having harmful influences to a human body are generated by photonuclear reaction on high-energy photon therapy. Their characteristics are not known in detail since the calculation to evaluate them takes very long time. PHITS(Particle and Heavy Ion Transport code System) Monte Carlo code since versions 2.80 has the new parameter "pnimul" raising the probability of occurring photonuclear reaction forcibly to make the efficiency of calculation. We investigated the optimum value of "pnimul" on high-energy photon therapy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047053/we-h-bra-06-experimental-investigation-of-rbe-for-lung-cancer-cell-lines-as-a-function-of-dose-and-let-in-proton-helium-and-carbon-beams
#16
D Patel, L Bronk, F Guan, C Peeler, D Mirkovic, D Grosshans, O Jakel, A Abdollahi, U Titt, R Mohan
PURPOSE: Investigate and quantify the effect of dose and LET on the RBE of protons, helium and carbon ions. METHODS: High throughput, high accuracy experimental setups were custom designed to investigate the Relative Biological Effectiveness (RBE) dependence on the dose and Linear Energy Transfer (LET) values for proton, helium and carbon ion beams. The experiment was conducted at the HIT facility in collaboration with the DKFZ in Heidelberg/Germany. Clonogenic assays of two human lung cancer cell lines, H460 and H1437, were investigated in this study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046959/we-fg-brb-03-challenges-and-opportunities-for-implementing-biological-optimization-in-particle-therapy
#17
D Carlson
The physical pattern of energy deposition and the enhanced relative biological effectiveness (RBE) of protons and carbon ions compared to photons offer unique and not fully understood or exploited opportunities to improve the efficacy of radiation therapy. Variations in RBE within a pristine or spread out Bragg peak and between particle types may be exploited to enhance cell killing in target regions without a corresponding increase in damage to normal tissue structures. In addition, the decreased sensitivity of hypoxic tumors to photon-based therapies may be partially overcome through the use of more densely ionizing radiations...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046841/su-g-bra-01-a-real-time-tumor-localization-and-guidance-platform-for-radiotherapy-using-us-and-mri
#18
B Bednarz, W Culberson, M Bassetti, A McMillan, C Matrosic, A Shepard, J Zagzebski, S Smith, W Lee, D Mills, K Cao, B Wang, E Fiveland, R Darrow, T Foo
PURPOSE: To develop and validate a real-time motion management platform for radiotherapy that directly tracks tumor motion using ultrasound and MRI. This will be a cost-effective and non-invasive real-time platform combining the excellent temporal resolution of ultrasound with the excellent soft-tissue contrast of MRI. METHODS: A 4D planar ultrasound acquisition during the treatment that is coupled to a pre-treatment calibration training image set consisting of a simultaneous 4D ultrasound and 4D MRI acquisition...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046645/su-f-t-125-radial-dose-distributions-from-carbon-ions-of-therapeutic-energies-calculated-with-geant4-dna
#19
O Vassiliev
PURPOSE: Radial dose distribution D(r) is the dose as a function of lateral distance from the path of a heavy charged particle. Its main application is in modelling of biological effects of heavy ions, including applications to hadron therapy. It is the main physical parameter of a broad group of radiobiological models known as the amorphous track models. Our purpose was to calculate D(r) with Monte Carlo for carbon ions of therapeutic energies, find a simple formula for D(r) and fit it to the Monte Carlo data...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046508/we-fg-brb-00-the-challenges-of-predicting-rbe-effects-in-particle-therapy-and-opportunities-for-improving-cancer-therapy
#20
David Carlson
The physical pattern of energy deposition and the enhanced relative biological effectiveness (RBE) of protons and carbon ions compared to photons offer unique and not fully understood or exploited opportunities to improve the efficacy of radiation therapy. Variations in RBE within a pristine or spread out Bragg peak and between particle types may be exploited to enhance cell killing in target regions without a corresponding increase in damage to normal tissue structures. In addition, the decreased sensitivity of hypoxic tumors to photon-based therapies may be partially overcome through the use of more densely ionizing radiations...
June 2016: Medical Physics
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