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https://www.readbyqxmd.com/read/28651352/circular-rna-profiling-reveals-that-circular-rnas-from-anxa2-can-be-used-as-new-biomarkers-for-multiple-sclerosis
#1
Iparraguirre Leire, Muñoz-Culla Maider, Prada Iñigo, Castillo-Triviño Tamara, Olascoaga Javier, Otaegui David
Multiple Sclerosis is an autoimmune disease, with higher prevalence in women, in whom the immune system is dysregulated. This dysregulation has been shown to correlate with changes in transcriptome expression as well as in gene-expression regulators, such as non-coding RNAs (e.g. microRNAs). Indeed, some of these have been suggested as biomarkers for multiple sclerosis even though few biomarkers have reached the clinical practice.Recently, a novel family of non-coding RNAs, circular RNAs, has emerged as a new player in the complex network of gene-expression regulation...
June 23, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28651345/prioritizing-quality-measure-concepts-at-the-interface-of-behavioral-and-physical-healthcare
#2
Harold Alan Pincus, Mingjie Li, Deborah M Scharf, Brigitta Spaeth-Rublee, Matthew L Goldman, Parashar P Ramanuj, Erin K Ferenchick
Objective: Integrated healthcare models can increase access to care, improve healthcare quality, and reduce cost for individuals with behavioral and general medical healthcare needs, yet there are few instruments for measuring the quality of integrated care. In this study, we identified and prioritized concepts that can represent the quality of integrated behavioral health and general medical care. Design: We conducted a literature review to identify candidate measure concepts...
June 23, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28651344/uterine-responses-to-early-pre-attachment-embryos-in-the-domestic-dog-and-comparisons-with-other-domestic-animal-species
#3
Felix R Graubner, Aykut Gram, Ewa Kautz, Stefan Bauersachs, Selim Aslan, Ali R Agaoglu, Alois Boos, Mariusz P Kowalewski
In the dog there is no luteolysis in the absence of pregnancy. Thus, this species lacks any anti-luteolytic endocrine signal as found in other species that modulate uterine function during the critical period of pregnancy establishment. Nevertheless, in the dog an embryo-maternal communication must occur in order to prevent rejection of embryos. Based on this hypothesis, we performed microarray analysis of canine uterine samples collected during pre-attachment phase (days 10-12) and in corresponding non-pregnant controls, in order to elucidate the embryo attachment signal...
June 23, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28651334/tsgsis-a-high-dimensional-grouped-variable-selection-approach-for-detection-of-whole-genome-snp-snp-interactions
#4
Yao-Hwei Fang, Jie-Huei Wang, Chao A Hsiung
Motivation: Identification of single nucleotide polymorphism (SNP) interactions is an important and challenging topic in genome-wide association studies (GWAS). Many approaches have been applied to detecting whole-genome interactions. However, these approaches to interaction analysis tend to miss causal interaction effects when the individual marginal effects are uncorrelated to trait, while their interaction effects are highly associated with the trait. Results: A grouped variable selection technique, called two-stage grouped sure independence screening (TS-GSIS), is developed to study interactions that may not have marginal effects...
June 23, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28651216/ultra-sensitive-suspended-atomically-thin-layered-black-phosphorus-mercury-sensors
#5
Peng Li, Dongzhi Zhang, Chuanxing Jiang, Xiaoqi Zong, Yuhua Cao
The extraordinary properties of black phosphorus (BP) make it a promising candidate for next-generation transistor chemical sensors. However, BP films reported so far are supported on substrate, and substrate scattering drastically deteriorates its electrical properties. Consequentially, the potential sensing capability of intrinsic BP is highly underestimated and its sensing mechanism is masked. Additionally, the optimum sensing regime of BP remains unexplored. This article is the first demonstration of suspended BP sensor operated in subthreshold regime...
June 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28651197/ascorbic-acid-protects-coccomyxa-subellipsoidea-against-metal-toxicity-through-modulation-of-ros-no-balance-and-metal-uptake
#6
Jozef Kováčik, Gabriela Rotková, Marek Bujdoš, Petr Babula, Viera Peterková, Peter Matúš
Impact of exogenous ascorbic acid (AsA, 100μM) on acute metal toxicity (Pb and Hg, 24h of exposure to 100μM) in unicellular green alga Coccomyxa subellipsoidea was studied. Hg (often extensively) depleted amount of pigments, potassium, soluble proteins, endogenous AsA, non-protein thiols and nitric oxide signal but elevated ROS signal and activities of catalase and superoxide dismutase. Responses to Pb application (if any) were less visible with ROS signal being slightly elevated and amount of non-protein thiols being slightly reduced...
June 16, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28651186/circulating-malondialdehyde-modified-low-density-lipoprotein-mda-ldl-as-a-novel-predictor-of-clinical-outcome-after-endovascular-therapy-in-patients-with-peripheral-artery-disease-pad
#7
Taka-Aki Takamura, Taketsugu Tsuchiya, Minako Oda, Makoto Watanabe, Ryuhei Saito, Ryoko Sato-Ishida, Hironobu Akao, Yasuyuki Kawai, Michihiko Kitayama, Kouji Kajinami
BACKGROUND AND AIMS: Despite advances in the treatment of peripheral artery disease (PAD), cardiovascular events and death rates remain high. This study aimed at identifying markers of outcome in patients with PAD undergoing endovascular therapy (EVT). METHODS: Consecutive patients undergoing EVT were recruited. Markers of oxidative stress (malondialdehyde-modified low-density lipoprotein [MDA-LDL]), inflammation (IL-6; high-sensitivity C-reactive protein [hsCRP]) and fibrinolysis (D-dimer) were measured pre-EVT and at post-EVT time-points to 36 h...
June 16, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28651134/effect-of-salt-type-and-concentration-on-the-growth-and-lipid-content-of-chlorella-vulgaris-in-synthetic-saline-wastewater-for-biofuel-production
#8
Jared Church, Jae-Hoon Hwang, Keug-Tae Kim, Rebecca McLean, You-Kwan Oh, Bora Nam, Jin Chul Joo, Woo Hyoung Lee
Microalgae can offer several benefits for wastewater treatment with their ability to produce large amounts of lipids for biofuel production and the high economic value of harvested biomass for biogas and fertilizer. This study found that salt concentration (∼45gL(-1)) had more of an effect than salt type on metabolisms of Chlorella vulgaris for wastewater treatment and biofuel production. Salinity stress decreased the algal growth rate in wastewater by 0.003day(-1)permScm(-1) and slightly reduced nutrient removal rates...
June 17, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28651081/inactivation-of-pathogenic-microorganisms-in-freshwater-using-hso5-uv-a-led-and-hso5-m-n-uv-a-led-oxidation-processes
#9
Jorge Rodríguez-Chueca, Tatiana Silva, José R Fernandes, Marco S Lucas, Gianluca Li Puma, José A Peres, Ana Sampaio
Freshwater disinfection using photolytic and catalytic activation of peroxymonosulphate (PMS) through PMS/UV-A LED and PMS/M(n+)/UV-A LED [M(n+) = Fe(2+) or Co(2+)] processes was evaluated through the inactivation of three different bacteria: Escherichia coli (Gram-negative), Bacillus mycoides (sporulated Gram-positive), Staphylococcus aureus (non-sporulated Gram-positive), and the fungus Candida albicans. Photolytic and catalytic activation of PMS were effective in the total inactivation of the bacteria using 0...
June 10, 2017: Water Research
https://www.readbyqxmd.com/read/28651026/binding-of-human-plasminogen-and-high-molecular-mass-kininogen-by-cell-surface-exposed-proteins-of-candida-parapsilosis
#10
Justyna Karkowska-Kuleta, Dorota Zajac, Grazyna Bras, Oliwia Bochenska, Maria Rapala-Kozik, Andrzej Kozik
Pathogenic microbes can recruit to their cell surface human proteins that are components of important proteolytic cascades involved in coagulation, fibrinolysis and innate immune response. Once located at the bacterial or fungal surface, such deployed proteins might be utilized by pathogens to facilitate invasion and dissemination within the host organism by interfering with functionality of these systems or by exploiting specific activity of the bound enzymes. Aim of the study presented here was to characterize this phenomenon in Candida parapsilosis (Ashford) Langeron et Talice - an important causative agent of systemic fungal infections (candidiases and candidemias) in humans...
June 24, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28651018/meta-analysis-of-mirna-expression-profiles-for-prostate-cancer-recurrence-following-radical-prostatectomy
#11
Elnaz Pashaei, Elham Pashaei, Maryam Ahmady, Mustafa Ozen, Nizamettin Aydin
BACKGROUND: Prostate cancer (PCa) is a leading reason of death in men and the most diagnosed malignancies in the western countries at the present time. After radical prostatectomy (RP), nearly 30% of men develop clinical recurrence with high serum prostate-specific antigen levels. An important challenge in PCa research is to identify effective predictors of tumor recurrence. The molecular alterations in microRNAs are associated with PCa initiation and progression. Several miRNA microarray studies have been conducted in recurrence PCa, but the results vary among different studies...
2017: PloS One
https://www.readbyqxmd.com/read/28651011/indications-of-airway-stenting-for-severe-central-airway-obstruction-due-to-advanced-cancer
#12
Hiroaki Nagano, Tomoo Kishaba, Yuichirou Nei, Shin Yamashiro, Hiroaki Takara
BACKGROUND: Management of severe central airway obstruction due to advanced cancer is a medical and technical challenge. The impact of airway stenting on the clinical outcome of such patients is unclear. METHOD: This single-center, retrospective study evaluated 21 patients who underwent airway stenting for advanced cancer. We examined predictors of the post-stenting mortality, including age, serum albumin, tracheal diameter, smoking, opioid use, respiratory failure, and performance status (PS)...
2017: PloS One
https://www.readbyqxmd.com/read/28650989/tumor-tissue-protein-signatures-reflect-histological-grade-of-breast-cancer
#13
Petter Skoog, Mattias Ohlsson, Mårten Fernö, Lisa Rydén, Carl A K Borrebaeck, Christer Wingren
Histological grade is one of the most commonly used prognostic factors for patients diagnosed with breast cancer. However, conventional grading has proven technically challenging, and up to 60% of the tumors are classified as histological grade 2, which represents a heterogeneous cohort less informative for clinical decision making. In an attempt to study and extend the molecular puzzle of histologically graded breast cancer, we have in this pilot project searched for additional protein biomarkers in a new space of the proteome...
2017: PloS One
https://www.readbyqxmd.com/read/28650978/a-study-of-ticks-and-tick-borne-livestock-pathogens-in-pakistan
#14
Shahid Karim, Khemraj Budachetri, Nabanita Mukherjee, Jaclyn Williams, Asma Kausar, Muhammad Jawadul Hassan, Steven Adamson, Scot E Dowd, Dmitry Apanskevich, Abdullah Arijo, Zia Uddin Sindhu, Muhammad Azam Kakar, Raja Muhammad Dilpazir Khan, Shafiq Ullah, Muhammad Sohail Sajid, Abid Ali, Zafar Iqbal
BACKGROUND: As obligate blood-feeding arthropods, ticks transmit pathogens to humans and domestic animals more often than other arthropod vectors. Livestock farming plays a vital role in the rural economy of Pakistan, and tick infestation causes serious problems with it. However, research on tick species diversity and tick-borne pathogens has rarely been conducted in Pakistan. In this study, a systematic investigation of the tick species infesting livestock in different ecological regions of Pakistan was conducted to determine the microbiome and pathobiome diversity in the indigenous ticks...
June 26, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28650835/a-new-representation-in-pso-for-discretization-based-feature-selection
#15
Binh Tran, Bing Xue, Mengjie Zhang
In machine learning, discretization and feature selection (FS) are important techniques for preprocessing data to improve the performance of an algorithm on high-dimensional data. Since many FS methods require discrete data, a common practice is to apply discretization before FS. In addition, for the sake of efficiency, features are usually discretized individually (or univariate). This scheme works based on the assumption that each feature independently influences the task, which may not hold in cases where feature interactions exist...
June 23, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28650830/feature-selection-based-on-neighborhood-discrimination-index
#16
Changzhong Wang, Qinghua Hu, Xizhao Wang, Degang Chen, Yuhua Qian, Zhe Dong
Feature selection is viewed as an important preprocessing step for pattern recognition, machine learning, and data mining. Neighborhood is one of the most important concepts in classification learning and can be used to distinguish samples with different decisions. In this paper, a neighborhood discrimination index is proposed to characterize the distinguishing information of a neighborhood relation. It reflects the distinguishing ability of a feature subset. The proposed discrimination index is computed by considering the cardinality of a neighborhood relation rather than neighborhood similarity classes...
June 23, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28650812/alpha-matting-with-kl-divergence-based-sparse-sampling
#17
Levent Karacan, Aykut Erdem, Erkut Erdem
In this paper, we present a new sampling-based alpha matting approach for the accurate estimation of foreground and background layers of an image. Previous sampling-based methods typically rely on certain heuristics in collecting representative samples from known regions, and thus their performance deteriorates if the underlying assumptions are not satisfied. To alleviate this, we take an entirely new approach and formulate sampling as a sparse subset selection problem where we propose to pick a small set of candidate samples that best explains the unknown pixels...
June 22, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28650731/combination-treatments-with-luteolin-and-fisetin-enhance-anti-inflammatory-effects-in-high-glucose-treated-thp-1-cells-through-histone-acetyltransferase-histone-deacetylase-regulation
#18
Arang Kim, Jung-Mi Yun
Hyperglycemia leads to diabetes and its diabetic complications. In this study, we investigated the synergistic effects of luteolin and fisetin on proinflammatory cytokine secretion and its underlying epigenetic regulation in human monocytes exposed to hyperglycemic (HG) concentrations. Human monocytic cells (THP-1) were cultured under controlled (14.5 mM mannitol), normoglycemic (5.5 mM glucose), or HG (20 mM glucose) conditions in the absence or presence of the two phytochemicals for 48 h. Whereas HG conditions significantly induced histone acetylation, nuclear factor-kappa B (NF-κB) activation, interleukin 6, and tumor necrosis factor-α release from THP-1 cells; combination treatments with the two phytochemicals (500 nM fisetin, and l μM and 500 nM luteolin) suppressed NF-κB activity and inflammatory cytokine release...
June 26, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28650717/heart-type-fatty-acid-binding-protein-is-a-sensitive-biomarker-for-early-ami-detection-in-troponin-negative-patients-a-pilot-study
#19
Luisa Agnello, Giulia Bivona, Giuseppina Novo, Concetta Scazzone, Roberto Muratore, Piero Levantino, Chiara Bellia, Bruna Lo Sasso, Marcello Ciaccio
BACKGROUND: Early detecting AMI in individuals presenting to the ED with chest pain continues to be a challenge. cTn is the gold standard for AMI diagnosis but early presenters (<1 hours from symptom onset) maybe cTn negative on admission. We analysed the diagnostic value of h-FABP and hs-TnI in patients presenting to ED with chest pain and no cTnI elevations. METHODS: 28 AMI and 28 no-AMI individuals both presented to ED within one hour from pain onset were included...
June 26, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28650657/noncovalent-pegylation-through-protein-polyelectrolyte-interaction-kinetic-experiment-and-molecular-dynamics-simulation
#20
Takaaki Kurinomaru, Kengo Kuwada, Shunsuke Tomita, Tomoshi Kameda, Kentaro Shiraki
Noncovalent binding of polyethylene glycol (PEG) to a protein surface is a unique protein handling technique to control protein function and stability. A diblock copolymer containing PEG and polyelectrolyte chains (PEGylated polyelectrolyte) is a promising candidate for noncovalent attachment of PEG to a protein surface because of the binding through multiple electrostatic interactions without protein denaturation. To obtain a deeper understanding of protein-polyelectrolyte interaction at the molecular level, we investigated the manner in which cationic PEGylated polyelectrolyte binds to anionic α-amylase in enzyme kinetic experiments and molecular dynamics (MD) simulations...
June 26, 2017: Journal of Physical Chemistry. B
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