keyword
MENU ▼
Read by QxMD icon Read
search

Aspergill*

keyword
https://www.readbyqxmd.com/read/28749255/pharmacokinetics-of-orally-administered-voriconazole-in-african-penguins-spheniscus-demersus-after-single-and-multiple-doses
#1
Michael W Hyatt, Nathan P Wiederhold, William W Hope, Katharine E Stott
Aspergillosis is a common respiratory fungal disease in African penguins ( Spheniscus demersus ) under managed care, and treatment failures with itraconazole due to drug resistance are increasingly common, leading to recent use of voriconazole. Empirical dosing with voriconazole based on other avian studies has resulted in adverse clinical drug effects in penguins. The objective of this study was to determine oral voriconazole pharmacokinetics (PK) in African penguins (n = 18). Single and once daily multiple oral doses of 5 mg/kg voriconazole were evaluated with a 4-mo washout period between trials...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28748288/talaromyces-sayulitensis-acidiella-bohemica-and-penicillium-citrinum-in-brazilian-oil-shale-by-products
#2
Kelly C G P de Goes, Josué J da Silva, Gisele M Lovato, Beatriz T Iamanaka, Fernanda P Massi, Diva S Andrade
Fine shale particles and retorted shale are waste products generated during the oil shale retorting process. These by-products are small fragments of mined shale rock, are high in silicon and also contain organic matter, micronutrients, hydrocarbons and other elements. The aims of this study were to isolate and to evaluate fungal diversity present in fine shale particles and retorted shale samples collected at the Schist Industrialization Business Unit (Six)-Petrobras in São Mateus do Sul, State of Paraná, Brazil...
July 26, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28748285/toward-the-standardization-of-mycological-examination-of-sputum-samples-in-cystic-fibrosis-results-from-a-french-multicenter-prospective-study
#3
Noémie Coron, Marc Pihet, Emilie Fréalle, Yolande Lemeille, Claudine Pinel, Hervé Pelloux, Gilles Gargala, Loic Favennec, Isabelle Accoceberry, Isabelle Durand-Joly, Frédéric Dalle, Frédéric Huet, Annlyse Fanton, Amale Boldron, Guy-André Loeuille, Philippe Domblides, Bérengère Coltey, Isabelle Pin, Catherine Llerena, Françoise Troussier, Christine Person, Christophe Marguet, Nathalie Wizla, Caroline Thumerelle, Dominique Turck, Stéphanie Bui, Michael Fayon, Alain Duhamel, Anne Prévotat, Benoit Wallaert, Sylvie Leroy, Jean-Philippe Bouchara, Laurence Delhaes
Fungal respiratory colonization of cystic fibrosis (CF) patients emerges as a new concern; however, the heterogeneity of mycological protocols limits investigations. We first aimed at setting up an efficient standardized protocol for mycological analysis of CF sputa that was assessed during a prospective, multicenter study: "MucoFong" program (PHRC-06/1902). Sputa from 243 CF patients from seven centers in France were collected over a 15-month period and submitted to a standardized protocol based on 6 semi-selective media...
July 26, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28747940/surgical-treatment-for-pulmonary-aspergilloma-early-and-long-term-results
#4
Mariusz Kasprzyk, Kornel Pieczyński, Krystian Mania, Piotr Gabryel, Cezary Piwkowski, Wojciech Dyszkiewicz
INTRODUCTION: Pulmonary aspergilloma is a difficult therapeutic problem due to the low effectiveness of conservative treatment and high surgical morbidity. AIM: To analyze the early and late results of surgical treatment for pulmonary aspergilloma. MATERIAL AND METHODS: From 2005 to 2015, 49 patients were treated surgically for pulmonary aspergilloma. Symptoms occurred in 85.7% of cases, including recurrent hemoptysis in 53%. A history of immunosuppressive therapy or chemotherapy was noted in 24...
June 2017: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/28747900/fungal-and-bacterial-diversity-isolated-from-aquilaria-malaccensis-tree-and-soil-induces-agarospirol-formation-within-3-months-after-artificial-infection
#5
Hemraj Chhipa, Nutan Kaushik
Aquilaria malaccensis Lam, commonly known as Agarwood, is a highly valuable species used in production of agar oil from its infected wood, which is utilized in pharmaceutical and perfumery industry. Agar oil formation in agarwood takes years through the natural process which is induced by natural or artificial injury or microbial infection. The role of soil fungi and bacteria in artificial induction is still an unexplored area. In the present study, we isolated the fungal and bacterial community residing inside the stem of A...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28747316/mitotic-nuclear-pore-complex-segregation-involves-nup2-in-aspergillus-nidulans
#6
Subbulakshmi Suresh, Sarine Markossian, Aysha H Osmani, Stephen A Osmani
Transport through nuclear pore complexes (NPCs) during interphase is facilitated by the nucleoporin Nup2 via its importin α- and Ran-binding domains. However, Aspergillus nidulans and vertebrate Nup2 also locate to chromatin during mitosis, suggestive of mitotic functions. In this study, we report that Nup2 is required for mitotic NPC inheritance in A. nidulans Interestingly, the role of Nup2 during mitotic NPC segregation is independent of its importin α- and Ran-binding domains but relies on a central targeting domain that is necessary for localization and viability...
July 26, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28747259/effects-of-biochar-amendment-on-bacterial-and-fungal-diversity-for-co-composting-of-gelatin-industry-sludge-mixed-with-organic-fraction-of-municipal-solid-waste
#7
Mukesh Kumar Awasthi, Jiao Li, Sunil Kumar, Sanjeev Kumar Awasthi, Quan Wang, Hongyu Chen, Meijing Wang, Xiuna Ren, Zengqiang Zhang
The aim of the study was to evaluate the bacterial and fungal diversities of 18contrastivecomposts applied with 17 different sources mad biochars applied treatments using 16S rRNA and 18S rDNA technology, while T-1 used as a control. The results showed that bacterial species of the phyla Actinobacteria, Proteobacteria and Chloroflexi, and fungi of the phylum Ascomycota and Basidiomycota were pre-dominant among the all treatments. The bacterial genus Subgroup_6_norank, Nocardioides, Pseudonocardia, Sphingomonas, Solirubrobacter and RB41_norank are first time identified in composting ecosystem...
July 14, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28746736/defensive-repertoire-of-drosophila-larvae-in-response-to-toxic-fungi
#8
Monika Trienens, Ken Kraaijeveld, Bregje Wertheim
Chemical warfare including insecticidal secondary metabolites is a well-known strategy for environmental microbes to monopolize a food source. Insects in turn have evolved behavioural and physiological defences to eradicate or neutralize the harmful microorganisms. We studied the defensive repertoire of insects in this interference competition by combining behavioural and developmental assays with whole-transcriptome time-series analysis. Confrontation with the toxic filamentous fungus Aspergillus nidulans severely reduced the survival of Drosophila melanogaster larvae...
July 26, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28746396/recovery-of-metallo-tolerant-and-antibiotic-resistant-psychrophilic-bacteria-from-siachen-glacier-pakistan
#9
Muhammad Rafiq, Muhammad Hayat, Alexandre M Anesio, Syed Umair Ullah Jamil, Noor Hassan, Aamer Ali Shah, Fariha Hasan
Cultureable bacterial diversity of previously unexplored Siachen glacier, Pakistan, was studied. Out of 50 isolates 33 (66%) were Gram negative and 17 (34%) Gram positive. About half of the isolates were pigment producers and were able to grow at 4-37°C. 16S rRNA gene sequences revealed Gram negative bacteria dominated by Proteobacteria (especially γ-proteobacteria and β-proteobacteria) and Flavobacteria. The genus Pseudomonas (51.51%, 17) was dominant among γ- proteobacteria. β-proteobacteria constituted 4 (12...
2017: PloS One
https://www.readbyqxmd.com/read/28745839/transcription-factor-agseb1-affects-development-osmotic-stress-response-and-secondary-metabolism-in-marine-derived-aspergillus-glaucus
#10
Yuan Wu, Yanna Ren, Xiangshan Zhou, Menghao Cai, Yuanxing Zhang
Fungi possess sophisticated regulatory systems to respond to a vast array of environmental signals. Among these responsive networks, some genes play critical roles in the regulation of various cellular processes. Here, we identified a putative transcriptional factor Agseb1 in Aspergillus glaucus, a marine-derived filamentous fungus. Agseb1 encodes a protein with two C2 H2 zinc fingers at the C-terminus, similar to the placement of these motifs in msn2/4 of Saccharomyces cerevisia, where they are positioned to allow binding to the CCCCT-box of stress-specific genes...
July 26, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/28745291/biogenic-fabrication-of-cunps-cu-bioconjugates-and-in-vitro-assessment-of-antimicrobial-and-antioxidant-activity
#11
Raksha Pandit, Swapnil Gaikwad, Mahendra Rai
In the present study, the authors synthesised copper nanoparticles (CuNPs) by using extract of Zingiber officinale (ginger) and later the NPs were bioconjugated with nisin, which shows antimicrobial activity against food spoilage microorganisms. CuNPs and its bioconjugate were characterised by ultraviolet-vis spectroscopy, NP tracking analysis, Zetasizer, transmission electron microscopy analysis, X-ray diffraction and Fourier transform infra-red (FTIR) spectroscopy. Zeta potential of CuNPs and its bioconjugate were found to be very stable...
August 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28745287/copper-nanoflowers-as-effective-antifungal-agents-for-plant-pathogenic-fungi
#12
Avinash P Ingle, Mahendra Rai
Flower-shaped copper nanoparticles were synthesised by a green and ecofriendly chemical reduction approach using copper sulphate and cytyltrimethal ammonium bromide. The UV-vis spectrophotometer analysis showed maximum absorption at about 552 nm, which is specifically reported for copper nanoparticles. The crystal lattice structure of copper nanoflowers was confirmed by X-ray diffraction analysis. Further, the transmission electron microscopic studies revealed the flower shape copper nanoparticles in the size range of 100-500 nm...
August 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28744084/singular-observation-of-a-desirable-change-after-bronchial-artery-embolization-for-hemoptysis-in-intracavitary-aspergilloma
#13
B P K Prasad, Brijesh Ray
Aspergillomas are fungal balls developing in pre-existing lung cavities, which are most commonly secondary to tuberculosis. Aspergillomas can cause hemoptysis due to erosion of the blood vessels in cavity walls, which can often be recurrent, massive, and life-threatening. Bronchial artery embolization is considered to be the treatment of choice for short-term control of hemoptysis, and lobectomy as the definitive treatment for aspergilloma. We present a unique observation in two cases of aspergilloma where the fungal balls disappeared radiologically after bronchial artery embolization performed for massive hemoptysis...
April 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28743811/structural-and-in-vivo-studies-on-trehalose-6-phosphate-synthase-from-pathogenic-fungi-provide-insights-into-its-catalytic-mechanism-biological-necessity-and-potential-for-novel-antifungal-drug-design
#14
Yi Miao, Jennifer L Tenor, Dena L Toffaletti, Stacey A Maskarinec, Jiuyu Liu, Richard E Lee, John R Perfect, Richard G Brennan
The disaccharide trehalose is critical to the survival of pathogenic fungi in their human host. Trehalose-6-phosphate synthase (Tps1) catalyzes the first step of trehalose biosynthesis in fungi. Here, we report the first structures of eukaryotic Tps1s in complex with substrates or substrate analogues. The overall structures of Tps1 from Candida albicans and Aspergillus fumigatus are essentially identical and reveal N- and C-terminal Rossmann fold domains that form the glucose-6-phosphate and UDP-glucose substrate binding sites, respectively...
July 25, 2017: MBio
https://www.readbyqxmd.com/read/28743702/progressive-dispersion-of-azole-resistance-in-aspergillus-fumigatus-fatal-invasive-aspergillosis-in-a-patient-with-acute-myeloid-leukemia-infected-with-an-a-fumigatus-strain-with-a-cyp51a-tr46-y121f-m172i-t289a-allele
#15
Susann Rößler, Oliver Bader, Friedrich Stölzel, Ulrich Sommer, Birgit Spiess, Stephan Geibel, Dieter Buchheidt, Uwe Groß, Gustavo Baretton, Enno Jacobs, Luis Ostrosky-Zeichner
Patients with hematologic malignancies as well as allogeneic hematopoietic stem cell transplantation (HSCT) patients are at high risk for invasive aspergillosis. Here, we report a culture- and autopsy-proven fatal invasive aspergillosis in an allogeneic HSTC patient which he developed despite posaconazole prophylaxis. The agent was determined to be an azole-resistant Aspergillus fumigatus strain bearing the cyp51A mutation combination TR46 Y121F M172I T289A. At increasing frequency, the azole resistance of A...
August 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28742650/reliable-and-easy-to-use-liquid-chromatography-tandem-mass-spectrometry-method-for-simultaneous-analysis-of-fluconazole-isavuconazole-itraconazole-hydroxy-itraconazole-posaconazole-and-voriconazole-in-human-plasma-and-serum
#16
Carsten Müller, David Gehlen, Cornelia Blaich, Domenik Prozeller, Blasius Liss, Thomas Streichert, Martin H J Wiesen
BACKGROUND: A fast and easy-to-use liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination and quantification of six triazoles (fluconazole (FLZ), isavuconazole (ISZ), itraconazole (ITZ), hydroxy-itraconazole (OH-ITZ), posaconazole (PSZ), voriconazole (VRZ)) in human plasma and serum was developed and validated for therapeutic drug monitoring (TDM). METHODS: Sample preparation was based on protein precipitation with acetonitrile and subsequent centrifugation...
July 24, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28742113/addition-of-17-allylamino-17-demethoxygeldanamycin-to-a-suboptimal-caspofungin-treatment-regimen-in-neutropenic-rats-with-invasive-pulmonary-aspergillosis-delays-the-time-to-death-but-does-not-enhance-the-overall-therapeutic-efficacy
#17
Jeannine M Refos, Alieke G Vonk, Marian T Ten Kate, Kimberly Eadie, Henri A Verbrugh, Irma A J M Bakker-Woudenberg, Wendy W J van de Sande
Caspofungin (CAS) which is used as salvage therapy in patients with invasive pulmonary aspergillosis (IPA) inhibits the 1,3-β-D-glucan synthesis in Aspergillus fumigatus. Inhibiting 1,3-β-D-glucan synthesis induces a stress response and in an invertebrate model it was demonstrated that inhibiting this response with geldamycin enhanced the therapeutic efficacy of CAS. Since geldamycin itself is toxic to mammalians, the therapeutic efficacy of combining geldamycin with CAS was not studied in rodent models. Therefore in this study we investigated if the geldamycin derivate 17-(allylamino)-17-demethoxygeldanamycin (17-AAG) was able to enhance the therapeutic efficacy of CAS in vitro and in our IPA model in transiently neutropenic rats...
2017: PloS One
https://www.readbyqxmd.com/read/28741738/aspergillus-calidoustus-case-series-and-review-of-the-literature
#18
Justin Seroy, Philip Antiporta, Shellee A Grim, Laurie A Proia, Kamaljit Singh, Nina M Clark
Aspergillus calidoustus, previously classified as Aspergillus ustus, is an emerging pathogen in immunocompromised persons. We describe four recent cases of A. calidoustus and review 37 additional cases of A. calidoustus (n=16) or A. ustus (n=25) published through June 2016. Twenty (49%) cases occurred in patients with hematologic malignancy and/or receipt of hematopoietic cell transplantation, and 13 (32%) occurred in solid organ transplant recipients. Antifungal susceptibility was reported in 49% of cases and in 42% treatment failed...
July 25, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28741551/disseminated-aspergillosis-in-an-hiv-positive-cannabis-user-taking-steroid-treatment
#19
Alex P Salam, Anton L Pozniak
No abstract text is available yet for this article.
August 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28740180/aspergillus-labruscus-sp-nov-a-new-species-of-aspergillus-section-nigri-discovered-in-brazil
#20
Maria Helena P Fungaro, Larissa S Ferranti, Fernanda P Massi, Josué J da Silva, Daniele Sartori, Marta H Taniwaki, Jens C Frisvad, Beatriz T Iamanaka
A novel fungal species, Aspergillus labruscus sp. nov., has been found in Brazil during an investigation of the fungal species present on the surface of grape berries (Vitis labrusca L.) for use in the production of concentrated grape juice. It seems to be associated to V. labrusca, and has never been recovered from Vitis vinifera. This new species belonging to Aspergillus subgenus Circumdati section Nigri is described here using morphological characters, extrolite profiling, partial sequence data from the BenA and CaM genes, and internal transcribed spacer sequences of ribosomal DNA...
July 24, 2017: Scientific Reports
keyword
keyword
54242
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"