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https://www.readbyqxmd.com/read/28646276/rhizopus-arrhizus-invasive-infection-due-to-self-inflicted-scratch-injuries-in-a-diabetic-patient-with-non-ketotic-acidosis
#1
Luis Buzón Martín, Miguel Ángel Morán Rodríguez, Nicole Mercier, Maria Ortega Lafont, Eva Ojeda Fernández, Ana Ruiz de la Parte, Miguel Estefanía
Mucormycosis is a rare infection caused by members included in the subphylum Mucoromycotina. Characterized by the histopathological hallmark of angioinvasion, these infections affect most often patients with certain underlying conditions carrying immunosuppression (haematological neoplasias, diabetic ketoacidosis and other forms of acidosis, and iron overload) or immunocompetent patients with traumatic mucocutaneous barriers breakdown and direct inoculation of the mould. A case is presented in which a rare underlying condition (non-ketotic acidosis) and a rare cause of cutaneous injuries collide...
June 23, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28639065/nosocomial-rhinocerebral-mucormycosis-two-cases-with-a-temporal-relationship
#2
Justo Sánchez-Gil, Emilio Guirao-Arrabal, Ginés David Parra-García, María Del Pilar Luzón-García, Maria Fe Bautista-Marín, Matías Barayobre-Barayobre, Andrés Fontalba-Navas
Mucormycosis is an unusual fungal infection that usually affects immunosuppressed patients. Small outbreaks of mucormycosis have been previously reported. We present two clinical cases of fatal rhinocerebral mucormycosis with a close temporal relationship between them and a possible nosocomial transmission: case 1 was a 75-year-old male with diabetes and COPD, treated with antibiotics and systemic corticosteroids, who developed rhinocerebral mucormycosis. Case 2 was an 88-year-old woman who was treated with systemic antibiotics and corticosteroids and developed the same infection after insertion of a nasogastric tube...
June 21, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28637506/improved-%C3%AE-linolenic-acid-production-in-mucor-circinelloides-by-homologous-overexpressing-of-delta-12-and-delta-6-desaturases
#3
Yao Zhang, Xiao Luan, Huaiyuan Zhang, Victoriano Garre, Yuanda Song, Colin Ratledge
BACKGROUND: γ-Linolenic acid (GLA) is important because of its nutritional value and medicinal applications. Although the biosynthetic pathways of some plant and microbial GLA have been deciphered, current understanding of the correlation between desaturases and GLA synthesis in oleaginous fungi is incomplete. In previous work, we found that a large amount of oleic acid (OA) had not been converted to linoleic acid (LA) or GLA in Mucor circinelloides CBS 277.49, which may be due to inadequate activities of the delta-12 or delta-6 desaturases, and thus leading to the accumulation of OA and LA...
June 21, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28623532/rhizopus-homothallicus-causing-invasive-infections-series-of-three-cases-from-a-single-centre-in-north-india
#4
Prathyusha Kokkayil, Mragnayani Pandey, Reshu Agarwal, Pratibha Kale, Gagandeep Singh, Immaculata Xess
Mucormycoses are opportunistic fungal infections with a high mortality rate. Rhizopus oryzae is the most common agent implicated in human infections. Although R. homothallicus has been previously reported to be a cause of pulmonary mucormycosis, it is the first time that we are reporting as a causative agent of rhino-orbital and cutaneous mucormycosis.
June 16, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28622118/imaging-spectrum-of-invasive-fungal-and-fungal-like-infections
#5
Hilary L P Orlowski, Sebastian McWilliams, Vincent M Mellnick, Sanjeev Bhalla, Meghan G Lubner, Perry J Pickhardt, Christine O Menias
Invasive fungal and fungal-like infections contribute to substantial morbidity and mortality in immunocompromised individuals. The incidence of these infections is increasing-largely because of rising numbers of immunocompromised patients, including those with neutropenia, human immunodeficiency virus, chronic immunosuppression, indwelling prostheses, burns, and diabetes mellitus, and those taking broad-spectrum antibiotics. Invasive fungal pathogens include primary mycotic organisms such as Histoplasma capsulatum, Coccidioides immitis, Blastomyces dermatitidis, and Paracoccidioides brasiliensis, which are true pathogens and inherently virulent...
June 16, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28621110/characterization-of-microbial-communities-in-chinese-rice-wine-collected-at-yichang-city-and-suzhou-city-in-china
#6
Yucai Lyu, Yanli Gong, Yajie Li, Zejiang Pan, Yi Yao, Ning Li, Jinling Guo, Dachun Gong, Yihong Ti, Caiyun Peng
Two typical microbial communities from Chinese rice wine fermentation collected in Yichang city and Suzhou city in China were investigated. Both communities could ferment glutinous rice to rice wine in 2 d. The sugar and ethanol contents were 198.67 and 14.47 mg/g, respectively, for rice wine from Yichang city, and 292.50 and 12.31 mg/g, respectively, for rice wine from Suzhou city. Acetic acid and lactic acid were the most abundant organic acids. Abundant fungi and bacteria were detected in both communities by high-throughput sequencing...
June 16, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28616783/a-search-for-glomuferrin-a-potential-siderophore-of-arbuscular-mycorrhizal-fungi-of-the-genus-glomus
#7
Günther Winkelmann
Most fungi are known to synthesize siderophores under iron limitation. However, arbuscular mycorrhizal fungi (AM fungi) have so far not been reported to produce siderophores, although their metabolism is iron-dependent. In an approach to isolate siderophores from AM fungi, we have grown plants of Tagetes patula nana in the presence of spores from AM fungi of the genus Glomus (G. etunicatum, G. mossae & unidentified Glomus sp.) symbiotically under iron limitation and sterile conditions. A siderophore was isolated from infected roots after 2-3 weeks of growth in pots containing low-iron sand with Hoagland solution...
June 14, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28616054/an-investigation-on-non-invasive-fungal-sinusitis-molecular-identification-of-etiologic-agents
#8
Abdolrasoul Mohammadi, Seyed Mostafa Hashemi, Sayed Hamidreza Abtahi, Seyed Mohammad Lajevardi, Sahar Kianipour, Rasoul Mohammadi
BACKGROUND: Fungal sinusitis is increasing worldwide in the past two decades. It is divided into two types including invasive and noninvasive. Noninvasive types contain allergic fungal sinusitis (AFS) and fungus ball. AFS is a hypersensitivity reaction to fungal allergens in the mucosa of the sinonasal tract in atopic individuals. The fungus ball is a different type of noninvasive fungal rhinosinusitis which is delineated as an accumulation of debris and fungal elements inside a paranasal sinus...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28610916/the-rhizoferrin-biosynthetic-gene-in-the-fungal-pathogen-rhizopus-delemar-is-a-novel-member-of-the-nis-gene-family
#9
Cassandra S Carroll, Clark L Grieve, Indu Murugathasan, Andrew J Bennet, Clarissa M Czekster, Huanting Lui, James Naismith, Margo M Moore
Iron is essential for growth and in low iron environments such as serum many bacteria and fungi secrete ferric iron-chelating molecules called siderophores. All fungi produce hydroxamate siderophores with the exception of Mucorales fungi, which secrete rhizoferrin, a polycarboxylate siderophore. Here we investigated the biosynthesis of rhizoferrin by the opportunistic human pathogen, Rhizopus delemar. We searched the genome of R. delemar 99-880 for a homologue of the bacterial NRPS-independent siderophore (NIS) protein, SfnaD, that is involved in biosynthesis of staphyloferrin A in Staphylococcus aureus...
June 10, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28597822/fungi-that-infect-humans
#10
Julia R Köhler, Bernhard Hube, Rosana Puccia, Arturo Casadevall, John R Perfect
Fungi must meet four criteria to infect humans: growth at human body temperatures, circumvention or penetration of surface barriers, lysis and absorption of tissue, and resistance to immune defenses, including elevated body temperatures. Morphogenesis between small round, detachable cells and long, connected cells is the mechanism by which fungi solve problems of locomotion around or through host barriers. Secretion of lytic enzymes, and uptake systems for the released nutrients, are necessary if a fungus is to nutritionally utilize human tissue...
June 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28597371/uptake-and-biotransformation-of-pure-commercial-microcystin-lr-versus-microcystin-lr-from-a-natural-cyanobacterial-bloom-extract-in-the-aquatic-fungus-mucor-hiemalis
#11
Maranda Esterhuizen-Londt, Stefanie Hertel, Stephan Pflugmacher
OBJECTIVES: To evaluate the remediation efficiency of Mucor hiemalis by comparing media elimination, uptake, and biotransformation of microcystin-LR with exposure to pure toxin versus a crude bloom extract. RESULTS: With exposure to the extract, the elimination rate of microcystin-LR from the media, which was 0.28 ng MC-LR l(-1) h(-1), was significantly higher compared to that achieved with exposure to the pure toxin (0.16 ng MC-LR l(-1) h(-1)) after 24 h...
June 8, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28596926/invasive-mucormycosis-induced-pneumopericardium-a-rare-cause-of-pneumopericardium-in-an-immunocompromised-patient
#12
Sana Khan, Muhammad Waqar Elahi, Waqas Ullah, Hafez Mohammad Ammar Abdullah, Ejaz Ahmad, Mayar Al Mohajer, Aneela Majeed
Mucor and Rhizopus cause life-threatening infections primarily involving the lungs and sinuses, which disseminate very rapidly by necrosis and infarction of the contiguous tissues. We present a case of a 64-year-old African American posttransplant patient who presented with a productive cough and weight loss. He had a past surgical history of renal transplant for renal cell carcinoma and was on dual immunosuppressive therapy, that is, mycophenolate and tacrolimus. During his hospital stay, he developed a pneumopericardium due to the direct extension of a lung lesion...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28593464/fine-root-endophytes-under-scrutiny-a-review-of-the-literature-on-arbuscule-producing-fungi-recently-suggested-to-belong-to-the-mucoromycotina
#13
REVIEW
Suzanne Orchard, Rachel J Standish, Ian A Dickie, Michael Renton, Christopher Walker, Derrick Moot, Megan H Ryan
Fine root endophytes (FRE) are arbuscule-forming fungi presently considered as a single species-Glomus tenue in the Glomeromycota (Glomeromycotina)-but probably belong within the Mucoromycotina. Thus, FRE are the only known arbuscule-forming fungi not within the arbuscular mycorrhizal fungi (AMF; Glomeromycotina) as currently understood. Phylogenetic differences between FRE and AMF could reflect ecological differences. To synthesize current ecological knowledge, we reviewed the literature on FRE and identified 108 papers that noted the presence of FRE and, in some, the colonization levels for FRE or AMF (or both)...
June 7, 2017: Mycorrhiza
https://www.readbyqxmd.com/read/28591186/increasing-incidence-of-mucormycosis-in-a-large-spanish-hospital-from-2007-to-2015-epidemiology-and-microbiological-characterization-of-the-isolates
#14
Jesús Guinea, Pilar Escribano, Antonio Vena, Patricia Muñoz, María Del Carmen Martínez-Jiménez, Belén Padilla, Emilio Bouza
We studied 19 cases of proven/probable mucormycosis diagnosed from 2007 to 2015 in our hospital and assessed the microbiological characteristics of the isolates. We recorded the incidence of mucormycosis and clinical and microbiological data of infected patients. Isolates were identified to molecular level and tested for their antifungal susceptibility to azoles, amphotericin B, and liposomal amphotericin B according to the CLSI M-38 A2 procedure. The incidence of mucormycosis in cases/100,000 hospital admissions during 2007-2015 increased significantly with respect to that reported in 1988-2006 (3...
2017: PloS One
https://www.readbyqxmd.com/read/28586604/orbital-involvement-in-sinonasal-diseases
#15
Zia-Us-Salam Qazi, Sarfraz Latif, Sadia Maqsood Awan
OBJECTIVE: Orbital involvement in sinonasal diseases can present as proptosis, ophthalmoplegia or even as blindness due to optic nerve damage. There are a number of sinonasal diseases which can involve eyes. The purpose of this study was to enlist diagnoses of all the patients with sinonasal disease, in which orbit was also involved unilaterally or bilaterally and to analyse the management strategy and final outcome in all the cases. METHODS: Hundred consecutive patients having orbital symptoms along with sinonasal complaints that presented in ENT department of Shaikh Zayed federal postgraduate medical institute were included in our prospective study...
October 2016: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28584996/endpoint-assessment-in-rabbit-models-of-invasive-pulmonary-aspergillosis-and-mucormycosis
#16
Vidmantas Petraitis, Ruta Petraitiene, William W Hope, Thomas J Walsh
Multiple animal models have been developed to study the pathogenesis of invasive pulmonary aspergillosis, as well as to evaluate the efficacy, pharmacokinetics, and pharmacodynamics of various antifungal agents and vaccines. Each model is beneficial depending on the questions that are asked. In this chapter, we will discuss the endpoints assessment of the persistently neutropenic rabbit models of invasive pulmonary aspergillosis and invasive pulmonary mucormycosis.
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28584912/new-cryptotanshinone-derivatives-with-anti-influenza-a-virus-activities-obtained-via-biotransformation-by-mucor-rouxii
#17
Wenni He, Yao Li, Yuejie Qin, Xiaomei Tong, Zhijun Song, Yu Zhao, Ran Wei, Li Li, Huanqin Dai, Wenzhao Wang, Houwei Luo, Xin Ye, Lixin Zhang, Xueting Liu
This paper provides an efficient platform to diversify the structure and pharmaceutical potentials of known natural products. Seven metabolites were obtained via the biotransformation of cryptotanshinone by the fungus Mucor rouxii AS 3.3447, and assigned as 13R-14R-hydroxy-anhydride of 16R-cryptotanshinone (1), 1S-hydroxy-anhydride of 16R-cryptotanshinone (2), 1R-hydroxy-anhydride of 16R-cryptotanshinone (3), 3S-hydroxy-epicryptoacetalide (4), 3S-hydroxy-cryptoacetalide (5), epicryptoacetalide (6), and cryptoacetalide (7)...
June 5, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28580534/fatal-pulmonary-mucormycosis-due-to-rhizopus-homothallicus
#18
Fabrice Compain, Nawel Aït-Ammar, Françoise Botterel, Laure Gibault, Francoise Le Pimpec Barthes, Eric Dannaoui
We report here a case of cavitary pneumonia due to Rhizopus homothallicus in a diabetic patient. This is the first proven case of R. homothallicus infection in Western countries and the third case described worldwide. The organism was isolated from lung biopsy and identified after amplification and sequencing of the internal transcribed spacer region.
June 3, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28580237/combination-liposomal-amphotericin-b-posaconazole-and-oral-amphotericin-b-for-treatment-of-gastrointestinal-mucorales-in-an-immunocompromised-patient
#19
Anthony Anderson, Dayna McManus, Sarah Perreault, Ying-Chun Lo, Stuart Seropian, Jeffrey E Topal
Mucormycosis is a life threatening infection caused by fungi in the order Mucorales. Mucormycosis can affect any organ system with rhino-orbital-cerebral and pulmonary infections being the most predominant infection types. Gastrointestinal mucormycosis is rare and accounts for only 4-7% of all cases. Here, we present a case of invasive gastrointestinal mucormycosis in an immunocompromised host treated with systemic and topical anti-mold therapy.
September 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28577122/successful-treatment-of-pulmonary-mucormycosis-caused-by-cunninghamella-bertholletiae-with-high-dose-liposomal-amphotericin-b-10%C3%A2-mg-kg-day-followed-by-a-lobectomy-in-cord-blood-transplant-recipients
#20
Hikari Ota, Hisashi Yamamoto, Muneyoshi Kimura, Hideki Araoka, Takeshi Fujii, Takashi Umeyama, Hideaki Ohno, Yoshitsugu Miyazaki, Daisuke Kaji, Yuki Taya, Aya Nishida, Kazuya Ishiwata, Masanori Tsuji, Shinsuke Takagi, Yuki Asano-Mori, Go Yamamoto, Naoyuki Uchida, Koji Izutsu, Kazuhiro Masuoka, Atsushi Wake, Akiko Yoneyama, Shigeyoshi Makino, Shuichi Taniguchi
Infection caused by Cunninghamella bertholletiae carries one of the highest mortality rates among mucormycosis, and there are no reported cases that survived from the infection in allogeneic hematopoietic stem cell transplantation recipients occurring before neutrophil engraftment. Here, we present two cases of pulmonary mucormycosis caused by C. bertholletiae occurring before neutrophil engraftment after cord blood transplantation. Both were successfully treated with high-dose liposomal amphotericin B (10 mg/kg/day) combined with micafungin, which was then followed by neutrophil recovery, reduction in immunosuppressive agents, and a subsequent lobectomy...
June 2, 2017: Mycopathologia
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