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https://www.readbyqxmd.com/read/28820315/immune-responses-to-mucorales-growth-forms-do-we-know-everything
#1
Emmanuel Roilides, Maria Simitsopoulou
No abstract text is available yet for this article.
August 18, 2017: Virulence
https://www.readbyqxmd.com/read/28816606/scale-up-of-puf-immobilized-fungal-chitosanase-lipase-preparation-production
#2
Katarzyna Struszczyk-Świta, Łukasz Stańczyk, Mirosława Szczęsna-Antczak, Tadeusz Antczak
Mucor circinelloides IBT-83 mycelium that exhibits both lipolytic (AL) and chitosanolytic (ACH) activities was immobilized into polyurethane foam (PUF) in a 30 L laboratory fermenter. The process of immobilization was investigated in terms of: the carrier porosity, its type, amount and shape, location inside the fermenter, mixing and aeration parameters during the culture, as well as downstream processing operations. The selected conditions allowed for immobilization of approx. 7 g of defatted and dried mycelium in 1 g of carrier, i...
August 17, 2017: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/28812135/pulmonary-mucormycosis-serial-morphologic-changes-on-computed-tomography-correlate-with-clinical-and-pathologic-findings
#3
Bo Da Nam, Tae Jung Kim, Kyung Soo Lee, Tae Sung Kim, Joungho Han, Myung Jin Chung
PURPOSE: To evaluate serial computed tomography (CT) findings of pulmonary mucormycosis correlated with peripheral blood absolute neutrophil count (ANC). MATERIALS AND METHODS: Between February 1997 and June 2016, 20 immunocompromised patients (10 males, 10 females; mean age, 48.9 years) were histopathologically diagnosed as pulmonary mucormycosis. On initial (n=20) and follow-up (n=15) CT scans, the patterns of lung abnormalities and their changing features on follow-up scans were evaluated, and the pattern changes were correlated with ANC changes...
August 10, 2017: European Radiology
https://www.readbyqxmd.com/read/28811815/hepatosplenic-mucormycosis-post-autologous-stem-cell-transplant
#4
Samia Yasmeen, Omer Waqas, Javeria Munir, Faisal Sultan, Abdul Hameed
Mucormycosis is a life threatening fungal infection and remains an important cause of morbidity and mortality in immunocompromised patients after hematopoietic stem cell transplant. We report here a case of hepatosplenic mucormycosis in a patient after autologous stem cell transplant. A young man with anaplastic large cell lymphoma underwent autologous hematopoietic stem cell transplant after achieving complete remission with standard chemotherapy and consolidative radiotherapy. He was found to have incidental hepatosplenic hypodensities on follow up imaging, that were proved to be mucormycosis on histopathology after getting CT-guided biopsy of splenic lesions...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28808367/isolated-renal-mucormycosis-in-immunocompetent-children-a-report-of-two-cases
#5
Sai Saran, Kirti Naranje, Mohan Gurjar, Dharmendra Bhadauria, Anupama Kaul, Banani Poddar
Isolated renal mucormycosis is a rare entity in children. It is potentially fatal when not detected and managed early with antifungal therapy, and surgery as and when needed. We present two immunocompetent children who developed this infection and subsequently succumbed to it. The diagnosis was established postmortem on renal biopsy specimens. We also discuss the 9 cases of isolated renal involvement in children published in literature.
July 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28806568/a-simple-high-performance-liquid-chromatography-mass-spectrometry-method-for-therapeutic-drug-monitoring-of-isavuconazole-and-four-other-antifungal-drugs-in-human-plasma-samples
#6
Giovanna Fatiguso, Fabio Favata, Ilaria Zedda, Amedeo De Nicolò, Jessica Cusato, Valeria Avataneo, Giovanni Di Perri, Antonio D'Avolio
Triazoles chanced the prevention and treatment of invasive fungal infections, but their pharmacokinetic properties are still unclear. In particular, isavuconazole (ISC) is a new broad-spectrum antifungal triazole approved in 2015 as first-line treatment for intravenous and oral use against invasive aspergillosis and for mucormycosis. Nowadays, the optimal management of the treatments with triazoles requires the use of Therapeutic Drug Monitoring (TDM), in order to prevent sub-therapeutic or toxic concentrations...
August 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28806142/mucormycosis-pathogenesis-beyond-rhizopus
#7
Brad Spellberg
No abstract text is available yet for this article.
August 14, 2017: Virulence
https://www.readbyqxmd.com/read/28805339/what-happens-in-the-pith-stays-in-the-pith-tissue-localized-defense-responses-facilitate-chemical-niche-differentiation-between-two-spatially-separated-herbivores
#8
Gisuk Lee, Youngsung Joo, Sang-Gyu Kim, Ian T Baldwin
Herbivore attack is known to elicit systemic defense responses that spread throughout the hostplant and influence the performance of other herbivores. While these plant-mediated indirect competitive interactions are well-described, and the co-existence of herbivores from different feeding guilds is common, the mechanisms of co-existence are poorly understood. In both field and glasshouse experiments with a native tobacco, Nicotiana attenuata, we found no evidence of negative interactions when plants were simultaneously attacked by two spatially separated herbivores: a leaf chewer Manduca sexta and a stem borer Trichobaris mucorea...
August 14, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28802855/antifungal-resistance-in-mucorales
#9
E Dannaoui
The order Mucorales, which includes the agents of mucormycosis, comprises a large number of species. These fungi are characterized by high-level resistance to most currently available antifungal drugs. Standardized antifungal susceptibility testing methods are now available, allowing a better understanding of the in vitro activity of antifungal drugs against members of Mucorales. Such tests have made apparent that antifungal susceptibility within this group may be species-specific. Experimental animal models of mucormycosis have also been developed and are of great importance in bridging the gap between in vitro results and clinical trials...
August 9, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28800827/modelling-the-effect-of-water-activity-reduction-by-sodium-chloride-or-glycerol-on-conidial-germination-and-radial-growth-of-filamentous-fungi-encountered-in-dairy-foods
#10
Nicolas Nguyen Van Long, Karim Rigalma, Louis Coroller, Robin Dadure, Stella Debaets, Jérôme Mounier, Valérie Vasseur
Water activity (aw) is one of the most influential abiotic factors affecting fungal development in foods. The effects of aw reduction on conidial germination and radial growth are generally studied by supplementing culture medium with the non-ionic solute glycerol despite food aw can also depend on the concentration of ionic solutes such as sodium chloride (NaCl). The present study aimed at modelling and comparing the effects of aw, either modified using NaCl or glycerol, on radial growth and/or conidial germination parameters for five fungal species occurring in the dairy environment...
December 2017: Food Microbiology
https://www.readbyqxmd.com/read/28797495/emergence-of-the-molds-other-than-aspergillus-in-immunocompromised-patients
#11
REVIEW
Sana Arif, John R Perfect
Immunocompromised patients are at high risk for invasive fungal infections (IFIs); although Aspergillus remains the most common IFI caused by molds, other fungi, such as Mucorales, dematiaceous molds, and Fusarium spp, are being seen with increasing frequency. Presentations can vary, but sinopulmonary and disseminated infections are common. Our understanding of the pathogenesis of these infections is rudimentary. Fungal cultures and histopathology remain the backbone of diagnostics, as no good serologic markers are available...
September 2017: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/28794960/gastric-perforation-after-duodenopancreatectomy
#12
Henrik Bäcker, Frank Jp Beeres, Marco Rossi, Andreas Scheiwiller
Fungal and bacterial infections are often which may cause sepsis. Mucormycosis is an unfrequent, but often life-threatening disease. A timely diagnosis and treatment is the cornerstone of success. An increase in incidence can be expected, given an aging population and increasing incidence of obesity, diabetes and cancer. We present a rare case where early diagnosis has helped to treat the patient mainly with antifungal therapy as surgical therapy has had high risk of complications.
December 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28792370/molecular-diagnosis-of-rhino-orbito-cerebral-mucormycosis-from-fresh-tissue-samples
#13
Kamran Zaman, Shivaprakash Mandya Rudramurthy, Ashim Das, Naresh Panda, Prasanna Honnavar, Harsimran Kaur, Arunaloke Chakrabarti
PURPOSE: We aimed to evaluate a PCR-based technique for the diagnosis of mucormycosis and the identification of fungi from fresh tissue specimens in patients with rhino-orbito-cerebral-mucormycosis (ROCM). METHODOLOGY: Fifty cases of ROCM were included in the study. Conventional identification was performed using microscopy and culture. Molecular diagnosis was performed by amplifying the ribosomal DNA using pan-fungal ITS primers and semi-nested Mucorales-specific primers of the 18S region...
August 9, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28783439/mucorales-spores-induce-a-proinflammatory-cytokine-response-in-human-mononuclear-phagocytes-and-harbor-no-rodlet-hydrophobins
#14
Sebastian Wurster, Vanessa Thielen, Philipp Weis, Paul Walther, Johannes Elias, Ana Maria Waaga-Gasser, Mariola Dragan, Thomas Dandekar, Hermann Einsele, Jürgen Löffler, Andrew J Ullmann
Mucormycoses are life-threatening infections in immunocompromised patients. This study characterizes the response of human mononuclear cells to different Mucorales and Ascomycota. PBMC, monocytes, and monocyte derived dendritic cells (moDCs) from healthy donors were stimulated with resting and germinated stages of Mucorales and Ascomycota. Cytokine response and expression of activation markers were studied. Both inactivated germ tubes and resting spores of Rhizopus arrhizus and other human pathogenic Mucorales species significantly stimulated mRNA synthesis and secretion of proinflammatory cytokines...
August 7, 2017: Virulence
https://www.readbyqxmd.com/read/28781150/2016-guidelines-for-the-use-of-antifungal-agents-in-patients-with-invasive-fungal-diseases-in-taiwan
#15
REVIEW
Hsiang-Chi Kung, Po-Yen Huang, Wei-Ting Chen, Bor-Sheng Ko, Yee-Chun Chen, Shan-Chwen Chang, Yin-Ching Chuang
The Infectious Diseases Society of Taiwan, Medical Foundation in Memory of Dr. Deh-Lin Cheng, Foundation of Professor Wei-Chuan Hsieh for Infectious Diseases Research and Education, and CY Lee's Research Foundation for Pediatric Infectious Diseases and Vaccines have updated the guidelines for the use of antifungal agents in adult patients with invasive fungal diseases in Taiwan. This guideline replaces the 2009 version. Recommendations are provided for Candida, Cryptococcus, Aspergillus and Mucormycetes. The focus is based on up-to-date evidence on indications for treatment or prophylaxis of the most common clinical problems...
July 25, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28771587/molecular-mechanisms-of-mucormycosis-the-bitter-and-the-sweet
#16
Clara Baldin, Ashraf S Ibrahim
No abstract text is available yet for this article.
August 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28767050/filamentous-fungal-human-pathogens-from-food-emphasising-aspergillus-fusarium-and-mucor
#17
REVIEW
R Russell M Paterson, Nelson Lima
Disease caused by filamentous fungal human pathogens (FFHP) is increasing. These organisms cause severe mycoses in immunosuppressed individuals, such as those: (a) with AIDS; (b) having undergone transplantation; and/or (c) undergoing chemotherapy. Immunocompetent people can become infected. Some FFHP are isolated from foods which may be fomites. However, the information concerning particular species on specific food is large, dispersed and difficult to obtain. Reports of filamentous fungi from food/crops and causing human disease are frequently only available in the literature of food mycology/plant pathology and medical mycology, respectively: it is seldom cross-referenced...
August 2, 2017: Microorganisms
https://www.readbyqxmd.com/read/28764159/otomycosis-in-a-rural-community-attending-a-tertiary-care-hospital-assessment-of-risk-factors-and-identification-of-fungal-and-bacterial-agents
#18
Priti Agarwal, Leimapokpam Sumitra Devi
INTRODUCTION: Otomycosis is one of the frequently encountered fungal infections of external auditory canal, commonly seen in tropical and subtropical regions of the world. Various host (local, systemic) and environmental factors can predispose a person to otomycosis. Although clinical presentations along with otoscopic findings of the patients are well suggestive of fungal infection, proper identification of causative agents is mandatory in order to prevent recurrences and complications...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28761224/mucormycosis-and-cytomegalovirus-co-infection-in-renal-transplant-recipients
#19
COMMENT
K L Gupta
No abstract text is available yet for this article.
July 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28757006/-pulmonary-mucormycosis-in-a-patient-with-kidney-transplant-and-uncontrolled-haemoptysis
#20
Dulce Iliana Navarro Vergara, Gloria Barragán Pola, Alexandro Bonifaz, Carlos Núñez Pérez-Redondo, Omar Choreño García, Raúl Cicero Sabido
BACKGROUND: Pulmonary mucormycosis is a rare opportunistic infection with high mortality that is caused by species of Mucorales. The most common species involved are Rhizopus, Mucor, Lichtheimia, and Rhizomucor. CASE REPORT: A 56 year-old woman presented with a clinical history of diabetes mellitus type 2 and chronic renal disease. She underwent a cadaveric kidney transplantation two years before her admission, for which immunomodulating therapy with thymoglobulin, tacrolimus, mofetil-microphenolate and prednisone was established...
July 27, 2017: Revista Iberoamericana de Micología
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