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Assaf A Barg, Sarah Malkiel, Maya Bartuv, Gahl Greenberg, Amos Toren, Nathan Keller
BACKGROUND: Invasive mold infections (IMIs) are a leading cause of mortality among immunocompromised patients. Isavuconazole is a new drug that shows promise in the adult population for the treatment of IMIs. No data regarding the use of isavuconazole in pediatric patients have been published. METHODS: Patients with a diagnosis of IMI from our pediatric hemato-oncology division, treated with isavuconazole between 2010 and 2016, were identified using the hospital's computerized database...
June 22, 2018: Pediatric Blood & Cancer
J Springer, I McCormick Smith, S Hartmann, R Winkelmann, D Wilmes, O Cornely, J Kessel, J Löffler, V Rickerts
Establishing the etiology of invasive fungal infections is important to guide therapeutic options and for epidemiologic purposes. Formalin-fixed, paraffin-embedded (FFPE) tissue specimens from patients with proven invasive fungal infections are valuable to determine the etiology of systemic fungal infections. We compared different polymerase chain reaction (PCR) amplification strategies from FFPE tissue blocks to identify agents of invasive fungal infections. We found that specific PCR assays show superior sensitivity in the identification of DNA of Mucorales and Aspergillus and mixed infections caused by both as compared to broad-range PCR assays...
June 19, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Elisabeth Maurer, Caroline Hörtnagl, Michaela Lackner, Denise Grässle, Verena Naschberger, Patrizia Moser, Esther Segal, Margarita Semis, Cornelia Lass-Flörl, Ulrike Binder
Mucorales can cause cutaneous to deep-seated infections, mainly in the immunocompromised host, resulting in high mortality rates due to late and inefficient treatment. In this study, Galleria mellonella larvae were evaluated as a heterologous invertebrate host to study pathogenicity of clinically relevant mucormycetes (Rhizopus spp., Rhizomucor spp., Lichtheimia spp., Mucor spp.). All tested species were able to infect G. mellonella larvae. Virulence potential was species-specific and correlated to clinical relevance...
June 19, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Yilun Wang, Min Zhu, Yunqi Bao, Li Li, Liping Zhu, Feng Li, Jinhua Xu, Jun Liang
RATIONALE: Cutaneous mucormycosis is an uncommon disease and occurs rarely in immunocompetent patients. PATIENT CONCERNS: We reported the case of a 37-year-old man presenting with a skin lesion on the left side of the chest wall with no history of trauma or primary diseases. He was firstly misdiagnosed as tuberculosis and the proper treatment was thus delayed. DIAGNOSES: Histopathological examination and fungal culture of the lesion confirmed cutaneous mucormycosis...
June 2018: Medicine (Baltimore)
Seindé Touré, Morgane Barthélémy, Jonathan Sorres, Grégory Genta-Jouve, Isabelle Dusfour, Véronique Eparvier, Didier Stien
The newly discovered macrolactone, mucorolactone, along with eight known compounds, was isolated from an ethyl acetate extract of the insect-borne fungus Mucor sp. All structures were elucidated using 1D and 2D NMR and MS spectroscopic experiments. Relative and absolute configurations of the original skeleton of mucorolactone was deduced from NOESY experiments, from the 13 C NMR chemical shift calculation based on the DP4 probability method, and from the comparison of experimental and calculated electronic circular dichroism spectra...
June 20, 2018: Organic Letters
Chengfang Geng, Xuelian Lv, Jie Li, Qing Jiang, Rongya Yang, Ping Zhan
Lichtheimia (formerly Absidia), is a genus of saprotrophic zygomycetous fungi which causes invasive mucormycosis in immunocompromised human hosts, e.g, patient with haematological malignancy, neutropenia, diabetes mellitus and organ transplantations, as well as long period of corticosteroid and immunosuppressant application. There has been an increase of Lichtheimia infections worldwide and the most common agents are reported to be Lichtheimia corymbifera. Primary cutaneous and subcutaneous infection is usually associated with immunodeficiency or trauma and presents as locally invasive, very rapid aggressive lesions due to this fungi's ability of angioinvasion...
June 17, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Karan Singla, Tanvir Samra, Nidhi Bhatia
Mucormycosis is an aggressive fungal infection caused by zygomycetes from the order of Mucorales . Immunocompromised patients or patients with comorbidities are susceptible to this infection. There are many forms of mucormycosis such as rhino-orbito-cerebral, cutaneous, gastrointestinal, and pulmonary. Cutaneous mucormycosis is rare in trauma patients with no comorbidities. Morel-Lavallée lesions are rare degloving injuries in trauma patients. We report a case of cutaneous mucormycosis in a trauma patient with the Morel-Lavallée lesions...
May 2018: Indian Journal of Critical Care Medicine
Debasis Gochhait, Arun Alexender, Priyadarshini Dehuri, Vidhyalakshmi Rangarajan, Sajini Elizabeth Jacob, Neelaiah Siddaraju
Isolated invasive Mucormycosis of the parotid gland is rarely reported in the literature (1). Mucormycosis most commonly manifests as rhino-oculocerebral and pulmonary infections in the patients with altered immunity (uncontrolled Diabetes mellitus, recipients of immunosupressive therapy and underlying hematological malignancies) (2). Rarely, it causes infection in the immunocompetent individuals (3) with the involvement of unusual sites like gastrointestinal tract, ear, soft tissue and skin (4, 5). This article is protected by copyright...
June 15, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Claire Aguilar, Shahid Husain, Olivier Lortholary
Background: Undergoing solid organ transplantation (SOT) exposes the recipient to various infectious risks, including possible transmission of pathogen by the transplanted organ, post-surgical infections, reactivation of latent pathogens, or novel infections. Recent advances: In the last few years, the emergence of Zika virus has raised concerns in the transplant community. Few cases have been described in SOT patients, and these were associated mainly with moderate disease and favorable outcome; the notable exception is a recent case of fatal meningo-encephalopathy in a heart transplant recipient...
2018: F1000Research
Saeed Nezafati, Abdolhassan Kazemi, Kasra Asgari, Amir Bahrami, Behrooz Naghili, Javad Yazdani
Inadequate data are available on the global epidemiology of mucormycosis, mainly derived from the evaluation of specific population groups. Rhinocerebral mucormycosis is an invading and fatal mycosis, particularly among diabetic patients. In the present study, patients hospitalized in Imam Reza Hospital in Tabriz, from 2007 to 2017, were evaluated. The hospital information system (HIS) was used to collect the records of the patients. A total of 42 patients with a diagnosis of mucormycosis were included in the study, 40 cases (95%) of which had a diagnosis of the rhinocerebral form...
June 13, 2018: Mycoses
Elisabeth Wehrle-Wieland, Kristina Affolter, Daniel Goldenberger, Sarah Tschudin Sutter, Joerg Halter, Jakob Passweg, Michael Tamm, Nina Khanna, Daiana Stolz
BACKGROUND: Accurate diagnosis of invasive mold diseases (IMD) remains challenging. Here, the performance of panfungal PCR, Aspergillus and Mucorales PCR in bronchoalveolar lavage (BAL) was evaluated. METHODS: We conducted a single-center study including 167 hematologic patients at risk for IMD with BAL performed 2011-2014. Diagnostic performance of single tests (Aspergillus-, Mucorales-and panfungal PCR, galactomannan (GM)≥0.5 and ≥1, culture/cytology) or in combination was calculated for predicting IMD comparing proven/probable or proven/probable/possible IMD versus no IMD, respectively...
June 13, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Joël E T Ateba, Rufin M K Toghueo, Angelbert F Awantu, Brice M Mba'ning, Sebastian Gohlke, Dinkar Sahal, Edson Rodrigues-Filho, Etienne Tsamo, Fabrice F Boyom, Norbert Sewald, Bruno N Lenta
There is continuing need for new and improved drugs to tackle malaria, which remains a major public health problem, especially in tropical and subtropical regions of the world. Natural products represent credible sources of new antiplasmodial agents for antimalarial drug development. Endophytes that widely colonize healthy tissues of plants have been shown to synthesize a great variety of secondary metabolites that might possess antiplasmodial benefits. The present study was carried out to evaluate the antiplasmodial potential of extracts from endophytic fungi isolated from Symphonia globulifera against a chloroquine-resistant strain of Plasmodium falciparum (PfINDO )...
June 12, 2018: Journal of Fungi (Basel, Switzerland)
Daiana Macedo, Florencia Leonardelli, Catiana Dudiuk, Laura Theill, Matías S Cabeza, Soledad Gamarra, Guillermo Garcia-Effron
Rhizopus oryzae is the most prevalent causative agent of Mucormycosis, an increasingly reported opportunistic fungal infection. These mucormycetes are intrinsically resistant to Candida - and Aspergillus -active antifungal azole drugs such as fluconazole and voriconazole, respectively. Despite of its importance, the molecular mechanisms of its intrinsic azole resistance have not been elucidated yet. The aim of this work is to establish if the Rhizopus oryzae CYP51 genes are the unique responsible for voriconazole and fluconazole intrinsic resistance in these fungal pathogens...
June 11, 2018: Antimicrobial Agents and Chemotherapy
Ming-Yu Lien, Chia-Hui Chou, Ching-Chan Lin, Li-Yuan Bai, Chang-Fang Chiu, Su-Peng Yeh, Mao-Wang Ho
This study investigated the epidemiology and risk factors associated with invasive fungal infections (IFIs) during induction chemotherapy in a cohort of Taiwanese patients with newly-diagnosed acute myeloid leukemia (AML). IFIs are a significant complication in the management of immunocompromised cancer patients; such infections are associated with a high incidence of morbidity and mortality, particularly in many South-Asian countries, where IFI rates are increasing. We retrospectively analyzed IFI incidence data from 105 patients with newly diagnosed AML at a single center undergoing their first course of induction chemotherapy without primary antifungal prophylaxis between November 2008 and December 2014...
2018: PloS One
Shalu Rai, Deepankar Misra, Akansha Misra, Ankit Jain, Prerna Jain, Ayush Dhawan
Mucormycosis is an acute, fulminating, fungal disease that frequently involves oral, cranial, and facial structures. It is an opportunistic fatal infection which occurs in debilitating and immunosuppressive states. This report documents a rare case of localized maxillary mucormycosis in a patient with uncontrolled diabetes, with emphasis on early and prompt diagnosis of the same.
April 2018: Contemporary Clinical Dentistry
Emeline E Scherer, Xavier Iriart, Anne Pauline Bellanger, Damien Dupont, Juliette Guitard, Frederic Gabriel, Sophie Cassaing, Eléna Charpentier, Sarah Guenounou, Murielle Cornet, Françoise Botterel, Steffi Rocchi, Ana Berceanu, Laurence Millon
Early diagnosis and treatment are essential to improving the outcome of mucormycosis. The aim of this retrospective study was to assess the contribution of quantitative PCR detection of Mucorales DNA in bronchoalveolar lavage fluids for early diagnosis of pulmonary mucormycosis.Bronchoalveolar lavage fluids (n=450) from 374 patients with pneumonia and immunosuppressive conditions were analyzed using a combination of 3 quantitative PCR assays targeting the main genera involved in mucormycosis in France ( Rhizomucor, Mucor/Rhizopus, Lichtheimia )...
June 6, 2018: Journal of Clinical Microbiology
Milissa U Jones, Michelle S Flores, Rasheda J Vereen, Sabrina R Szabo, Nicholas F Logemann, Matthew D Eberly
A 7-week-old girl, born at 30 weeks' gestational age, presented to clinic for evaluation of a crop of vesicular lesions that were noted after removal of a bandage that had been in place for 4 days. A punch biopsy of the lesion revealed fungal elements that were later identified as Rhizopus spp. The lesion began to self-resolve, and no further treatment was needed, with full resolution of the lesion by 1 month after presentation. Clinicians should be aware of the variable presentations of mucormycosis and consider fungal infection in the differential diagnosis when evaluating vulnerable patients with skin eruptions...
May 30, 2018: Pediatric Dermatology
R Usha Devi, Anitha Balachandran, C N Kamalarathnam, S Pappathi
BACKGROUND: Mucormycosis of the gastrointestinal tract is a rare fungal infection of neonates. CASE CHARACTERISTICS: 48-hours-old term neonate presented with intestinal obstruction and perforation. No significant risk factors were present. Histopathological examination of the resected gangrenous bowel revealed mucormycosis. Cutaneous involvement due to systemic spread led to dermal necrosis in toes. OUTCOME: Though cutaneous lesions responded promptly to antifungal therapy, gastrointestinal manifestations required multiple antifungal therapy for prolonged period apart from surgical debridement...
May 15, 2018: Indian Pediatrics
Inga Bazukyan, Lusine Matevosyan, Anna Toplaghaltsyan, Armen Trchounian
Different strains of lactobacilli isolated from Armenian dairy products (matsoun, sour cream and different types of cheeses), were studied for antifungal activity. Lactobacillus rhamnosus MDC 9661 strain was shown to have inhibitory activity against Penicillium aurantioviolaceum and Mucor plumbeus growth. Bacterial cell-free supernatant didn't show antifungal activity. The L. rhamnosus antifungal activity was stable to the wide range of pH from 3 to 10. This activity was high after treatment with both low temperature (- 30 °C) and lysozyme and with ultrasound...
May 28, 2018: AMB Express
A Sharifpour, N Gholinejad-Ghadi, R Ghasemian, Z Seifi, S R Aghili, E Zaboli, R Abdi, T Shokohi
The patients with hematologic malignancies and hematopoietic stem cell transplantation (HSCT) recipients are at high risk for invasive fungal diseases (IFDs) mainly due to the severe and prolonged neutropenia related to high-dose chemotherapy. Voriconazole prophylaxis is recommended for possible IFDs. Mucormycosis is a fulminant infection, which may occur after voriconazole prophylaxis for invasive aspergillosis in immunocompromised hosts. Here, we report mucormycosis after 4 months of voriconazole prophylaxis in a young patient with relapsed acute lymphoblastic leukemia and hematopoietic stem cell transplant failure and discuss the clinical manifestation, imaging, laboratory findings and therapeutic regimens...
May 25, 2018: Journal de Mycologie Médicale
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