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https://www.readbyqxmd.com/read/29217228/primary-cutaneous-mucormycosis-due-to-rhizopus-arrhizus-in-an-8-year-old-girl
#1
M F Albízuri-Prado, A Sánchez-Orta, A Rodríguez-Bandera, M Feito-Rodríguez
No abstract text is available yet for this article.
December 4, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29200154/rhinocerebral-mucormycosis-with-temporal-artery-thrombosis-in-an-adolescent-following-hla-haploidentical-stem-cell-transplantation
#2
Yuta Kawahara, Shoya Wada, Hitomi Nijima, Tomomi Hayase, Rieko Furukawa, Kentaro Ashizawa, Akira Morimoto
Rhinocerebral mucormycosis (RCM) can lead to internal carotid artery thrombosis. Here, we report the first case of RCM with temporal artery thrombosis following HLA-haploidentical stem cell transplantation in an adolescent presenting with low-grade fever, right mandibular pain, and right jaw claudication. This case suggests that RCM can cause temporal artery thrombosis and should be considered as a differential diagnosis in severely immunocompromised patients with maxillary sinusitis presenting with jaw claudication...
December 1, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29199126/chitosan-produced-from-mucorales-fungi-using-agroindustrial-by-products-and-its-efficacy-to-inhibit-colletotrichum-species
#3
Lúcia Raquel Ramos Berger, Thayza Christina Montenegro Stamford, Kataryne Árabe Rimá de Oliveira, Adjane de Miranda Pereira Pessoa, Marcos Antonio Barbosa de Lima, Maria Manuela Estevez Pintado, Marcos Paz Saraiva Câmara, Luciana de Oliveira Franco, Marciane Magnani, Evandro Leite de Souza
This study evaluated corn steep liquor (CSL) and papaya peel juice (PPJ) in mixture as substrates for the cultivation (96h, 28°C, pH 5.6, 150rpm) of Mucorales fungi for chitosan production, and determined the growth-inhibitory effect of the fungal chitosan (FuCS) obtained under optimized conditions against phytopathogenic Colletotrichum species. All Mucorales fungi tested were capable of growing in CSL-PPJ medium, showing FuCS production in the range of 5.02 (Fennelomyces heterothalicus SIS 28) - 15.63mg/g (Cunninghamella elegans SIS 41)...
November 30, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29196656/development-of-a-plasmid-free-crispr-cas9-system-for-the-genetic-modification-of-mucor-circinelloides
#4
Gábor Nagy, Csilla Szebenyi, Árpád Csernetics, Amanda Grace Vaz, Eszter Judit Tóth, Csaba Vágvölgyi, Tamás Papp
Mucor circinelloides and other members of Mucorales are filamentous fungi, widely used as model organisms in basic and applied studies. Although genetic manipulation methods have been described for some Mucoral fungi, construction of stable integrative transformants by homologous recombination has remained a great challenge in these organisms. In the present study, a plasmid free CRISPR-Cas9 system was firstly developed for the genetic modification of a Mucoral fungus. The described method offers a rapid but robust tool to obtain mitotically stable mutants of M...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29195769/mucormycete-infiltration-in-the-cardiac-conduction-system
#5
Takashi Nawata, Makoto Kubo, Shigeki Kobayashi, Narumi Nakada, Masaki Maeda, Dan Cui, Tokuhiro Kimura, Eiji Ikeda, Masafumi Yano
No abstract text is available yet for this article.
October 5, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29190812/diagnostic-performance-of-the-1-3-%C3%AE-d-glucan-assay-in-patients-with-pneumocystis-jirovecii-compared-with-those-with-candidiasis-aspergillosis-mucormycosis-and-tuberculosis-and-healthy-volunteers
#6
Hyo-Ju Son, Heungsup Sung, Se Yoon Park, Taeeun Kim, Hyun Jeong Lee, Sun-Mi Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung-Han Kim
BACKGROUND: Diagnosis of pneumocystis pneumonia (PCP) relies on microscopic visualization of P. jirovecii, or detection of Pneumocystis DNA in respiratory specimens, which involves invasive procedures such as bronchoalveolar lavage. The (1-3)-β-D-glucan (BG) assay has been proposed as a less invasive and less expensive diagnostic test to rule out PCP. We therefore compared blood levels of BG in patients with PCP with those of patients with candidemia, chronic disseminated candidiasis (CDC), invasive aspergillosis, mucormycosis, and tuberculosis and those of healthy volunteers...
2017: PloS One
https://www.readbyqxmd.com/read/29189615/multi-modal-treatment-of-rhinocerebral-mucormycosis-in-a-pediatric-patient-with-relapsed-pre-b-acute-lymphoblastic-leukemia
#7
Zephyr D Dworsky, John S Bradley, Matthew T Brigger, Alice L Pong, Dennis John Kuo
A 17-year-old female developed invasive rhinocerebral mucormycosis during intensive re-induction chemotherapy for relapsed pre-B acute lymphoblastic leukemia. Due to the high case fatality rate for invasive mucormycosis in profoundly immunosuppressed patients, an aggressive treatment regimen was pursued. In addition to the standard of care treatments with intravenous amphotericin and aggressive surgical debridements, she received intraventricular amphotericin to the brain via an Ommaya reservoir, hyperbaric oxygen treatments, filgrastim, intravenous immunoglobulin and anti-fungal in vitro synergy testing to allow for more targeted antifungal therapy with the addition of micafungin...
November 16, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29189511/invasive-fungal-disease-in-pediatric-acute-leukemia-in-the-nontransplant-setting-8-years-experience-from-a-tertiary-care-center-in-north-india
#8
Anirban Das, Sapna Oberoi, Amita Trehan, Arunaloke Chakrabarti, Deepak Bansal, Akshay K Saxena, Kushaljit S Sodhi, Nandita Kakkar, Radhika Srinivasan
BACKGROUND/AIM: The aim of this article is to study the spectrum, changing prevalence, and predictors for mortality of invasive fungal disease (IFD) in pediatric leukemia in a resource-limited setting. OBSERVATIONS: Prevalence was 7% (proven, 69%; probable, 16.4%; possible, 14.6%) and did not differ between acute lymphoblastic leukemia and acute myeloid leukemia. Lungs were frequently involved (46%). Aspergillus was the commonest fungus (47%). Visceral abscesses were frequent with candidiasis as compared with invasive molds (P=0...
November 17, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29188178/tumor-shape-pulmonary-mucormycosis-associated-with-sinonasal-aspergillosis-in-a-diabetic-patient
#9
Sophie Point, Frédéric Gabriel, Hugues Bégueret, Jacques Jougon, Fanny Lanternier, Frédéric Grenouillet, Manal Abdel Fattah, Emilie Catherinot, Chantal Raherison, Elodie Blanchard
Mucormycosis is a rare and life-threatening fungal infection of the Mucorales order occurring mainly in immunosuppressed patients. The most common forms are rhinocerebral but pulmonary or disseminated forms may occur. We report the case of a 61-year-old patient in whom pulmonary mucormycosis was diagnosed during his first-ever episode of diabetic ketoacidosis. While receiving liposomal amphotericin B, a sinusal aspergillosis due to Aspergillus fumigatus occurred. Evolution was slowly favorable under antifungal tritherapy by liposomal amphotericin B, posaconazole and caspofungin...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29187564/a-comparison-of-aspergillus-and-mucorales-pcr-testing-of-different-bal-fractions-from-patients-with-suspected-invasive-pulmonary-fungal-disease
#10
Jan Springer, P Lewis White, Johanna Kessel, Imke Wieters, Daniel Teschner, Daniel Korczynski, Tobias Liebregts, Oliver A Cornely, Stefan Schwartz, Thomas Elgeti, Lisa Meintker, Stefan W Krause, Raquel B Posso, Werner J Heinz, Sandra Fuhrmann, Jörg Janne Vehreschild, Hermann Einsele, Volker Rickerts, Juergen Loeffler
In patients with haematological malignancies, bronchoalveolar lavage fluid specimens (BALF) are commonly used for the diagnosis of mould infections. However, it is not clear whether the cellular pellet (P) or the supernatant fraction (S) of the BALF is optimal for molecular diagnostic testing. Thus, 99 BALF specimens from 96 haematology patients with or without allogeneic hematopoietic stem cell transplant were collected. Pellets and supernatants were processed alone and in combination (S/P) by two fungal-specific real-time PCR assays compliant with international recommendations...
November 29, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29186341/invasive-fungal-sinusitis-due-to-mucor-species-in-a-patient-on-ibrutinib
#11
David Phillip Serota, Aneesh K Mehta, Varun K Phadke
No abstract text is available yet for this article.
November 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29186239/cutaneous-mucormycosis
#12
Ana Daniela Castrejón-Pérez, Esperanza C Welsh, Ivett Miranda, Jorge Ocampo-Candiani, Oliverio Welsh
Cutaneous mucormycosis is an emerging fungal infection caused by opportunistic fungi of the phylum Glomeromycota. It is frequent in poorly controlled diabetic patients and individuals with immunosuppression. It is usually acquired by direct inoculation through trauma. The clinical presentation is nonspecific, but an indurated plaque that rapidly evolves to necrosis is a common finding. Diagnosis should be confirmed by demonstration of the etiological agent and new molecular diagnostic tools have recently been described...
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29184190/bacterial-endosymbionts-influence-host-sexuality-and-reveal-reproductive-genes-of-early-divergent-fungi
#13
Stephen J Mondo, Olga A Lastovetsky, Maria L Gaspar, Nicole H Schwardt, Colin C Barber, Robert Riley, Hui Sun, Igor V Grigoriev, Teresa E Pawlowska
Many heritable mutualisms, in which beneficial symbionts are transmitted vertically between host generations, originate as antagonisms with parasite dispersal constrained by the host. Only after the parasite gains control over its transmission is the symbiosis expected to transition from antagonism to mutualism. Here, we explore this prediction in the mutualism between the fungus Rhizopus microsporus (Rm, Mucoromycotina) and a beta-proteobacterium Burkholderia, which controls host asexual reproduction. We show that reproductive addiction of Rm to endobacteria extends to mating, and is mediated by the symbiont gaining transcriptional control of the fungal ras2 gene, which encodes a GTPase central to fungal reproductive development...
November 29, 2017: Nature Communications
https://www.readbyqxmd.com/read/29182775/transcriptional-profile-of-the-human-skin-pathogenic-fungus-mucor-irregularis-in-response-to-low-oxygen
#14
Wenqi Xu, Jingwen Peng, Dongmei Li, Clement K M Tsui, Zhimin Long, Qiong Wang, Huan Mei, Weida Liu
No abstract text is available yet for this article.
November 22, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29178247/isavuconazole-shortens-the-qtc-interval
#15
Sibylle C Mellinghoff, Matteo Bassetti, Daniela Dörfel, Stefan Hagel, Nicola Lehners, Andrzej Plis, Enrico Schalk, Antonio Vena, Oliver A Cornely
BACKGROUND: Isavuconazole is a novel antifungal drug, approved for treatment of adults with invasive aspergillosis and mucormycosis. While azoles as a class effect are known to prolong QTc interval, clinical trials have shown that isavuconazole administration may cause shortening in a dose-related manner. Here, we assessed the effects of isavuconazole on the length of QTc interval. OBJECTIVES: To describe changes of the QTc interval induced by isavuconazole treatment...
November 25, 2017: Mycoses
https://www.readbyqxmd.com/read/29177719/structural-features-influential-to-enzymatic-hydrolysis-of-cellulose-solvent-based-pretreated-pinewood-and-elmwood-for-ethanol-production
#16
Behzad Satari, Keikhosro Karimi, Maryam Molaverdi
Dissolution of lignocelluloses in N-methylmorpholine-N-oxide (NMMO or NMO) at moderate conditions, e.g., 120 °C for 3 h under atmospheric pressure, and regeneration with water, is among the most effective nonderivatization pretreatment for the improvement of enzymatic hydrolysis and ethanol production. The effects of the pretreatment on two different types of wood, hardwood elm and softwood pine, were compared via physicochemical structural analyses, i.e., FTIR, XRD, SEM, TGA, and enzyme adsorption techniques, to relate their properties to the extent of enzymatic conversion...
November 24, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29175660/chemo-enzymatic-synthesis-of-the-glucagon-containing-n-linked-oligosaccharide-and-its-characterization
#17
Takayuki Higashiyama, Midori Umekawa, Masaya Nagao, Toshihiko Katoh, Hisashi Ashida, Kenji Yamamoto
The chemo-enzymatic synthesis of an artificially N-glycosylated derivative of glucagon, a peptide hormone that regulates the blood sugar level, is described. We synthesized the glycosylated glucagon by chemical synthesis of an N-acetylglucosaminyl peptide and enzymatic transfer of an oligosaccharide using the transglycosylation activity of the glycosynthase-like mutant of Mucor hiemalis endo-β-N-acetylglucosaminidase (Endo-M) and sialo-oligosaccharide oxazoline as a donor substrate. The sialo-oligosaccharide-attached glucagon synthesized showed high resistance against protease degradation and stimulated the release of glucose from mouse hepatocytes when added to cells...
November 13, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/29172240/disseminated-mucormycosis-masquerading-as-rejection-early-after-orthotopic-heart-transplantation
#18
Lindsay Margoles, David DeNofrio, Ayan Patel, Yoav Golan, Amanda Vest, Knarik Arkun, Helen Boucher, Michael Kiernan, Jenica Upshaw
Mucorales organisms are an uncommon cause of invasive fungal infections after solid organ transplantation but are associated with great morbidity and mortality. We report a fatal case of disseminated Cunninghamella infection early after heart transplantation. The patient developed graft dysfunction and elevated markers of myocyte injury and autopsy revealed fulminant fungal myocarditis. This case highlights the need for a high index of suspicion in immunocompromised patients who are not improving with standard antimicrobial therapy...
November 24, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29171398/primary-cutaneous-mucormycosis-as-a-complication-of-erosive-dermatitis-two-cases
#19
Devy Lu, Camille Hua, Amandine Servy, Francoise Foulet, Francoise Botterel, Nicolas De Prost, Olivier Ellrodt, Berline Sigha, Dragos Popescu, Nicolas Ortonne, Pierre Wolkenstein, Saskia Ingen-Housz-Oro, Olivier Chosidow
No abstract text is available yet for this article.
November 24, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29170658/fungal-community-structure-and-as-resistant-fungi-in-a-decommissioned-gold-mine-site
#20
Silvia Crognale, Alessandro D'Annibale, Lorena Pesciaroli, Silvia R Stazi, Maurizio Petruccioli
Although large quantities of heavy metal laden wastes are released in an uncontrolled manner by gold mining activities with ensuing contamination of the surrounding areas, there is scant information on the mycobiota of gold-mine sites. Thus, the present study was aimed to describe the fungal community structure in three differently As- and Hg-polluted soils collected from the Pestarena decommissioned site by using Illumina® metabarcoding. Fungal richness was found to increase as the contamination level increased while biodiversity was not related to the concentrations of inorganic toxicants...
2017: Frontiers in Microbiology
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