Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
REVIEW
Ali Jendoubi, Claire Pressiat, Quentin De Roux, Anne Hulin, Bijan Ghaleh, Renaud Tissier, Matthias Kohlhauer, Nicolas Mongardon
BACKGROUND AND OBJECTIVE: The use of extracorporeal membrane oxygenation (ECMO) as a cardiocirculatory or respiratory support has tremendously increased in critically ill patients. In the setting of ECMO support, invasive fungal infections are a severe cause of morbidity and mortality. This vulnerable population is at risk of suboptimal antifungal exposure due to an increased volume of distribution (Vd), drug sequestration and decreased clearance. Here, we aimed to summarize ex-vivo and clinical studies on the potential impact of ECMO on the pharmacokinetics (PK) of antifungal agents and dosing requirements...
December 29, 2023: International Journal of Antimicrobial Agents
#22
JOURNAL ARTICLE
Judith Díaz-García, Marina Machado, Luis Alcalá, Elena Reigadas, Ana Pérez-Ayala, Elia Gómez-García de la Pedrosa, Fernando Gónzalez-Romo, María Soledad Cuétara, Coral García-Esteban, Inmaculada Quiles-Melero, Nelly Daniela Zurita, María Muñoz-Algarra, María Teresa Durán-Valle, Aida Sánchez-García, Patricia Muñoz, Pilar Escribano, Jesus Guinea
We previously conducted a multicenter surveillance study on Candida epidemiology and antifungal resistance in Madrid (CANDIMAD study; 2019-2021), detecting an increase in fluconazole-resistant Candida parapsilosis . We here present data on isolates collected in 2022. Furthermore, we report the epidemiology and antifungal resistance trends during the entire period, including an analysis per ward of admission. Candida spp. incident isolates from blood cultures and intra-abdominal samples from patients cared for at 16 hospitals in Madrid, Spain, were tested with the EUCAST E...
November 15, 2023: Antimicrobial Agents and Chemotherapy
#23
REVIEW
Karolina M Czajka, Krishnan Venkataraman, Danielle Brabant-Kirwan, Stacey A Santi, Chris Verschoor, Vasu D Appanna, Ravi Singh, Deborah P Saunders, Sujeenthar Tharmalingam
Candidiasis is a highly pervasive infection posing major health risks, especially for immunocompromised populations. Pathogenic Candida species have evolved intrinsic and acquired resistance to a variety of antifungal medications. The primary goal of this literature review is to summarize the molecular mechanisms associated with antifungal resistance in Candida species. Resistance can be conferred via gain-of-function mutations in target pathway genes or their transcriptional regulators. Therefore, an overview of the known gene mutations is presented for the following antifungals: azoles (fluconazole, voriconazole, posaconazole and itraconazole), echinocandins (caspofungin, anidulafungin and micafungin), polyenes (amphotericin B and nystatin) and 5-fluorocytosine (5-FC)...
November 19, 2023: Cells
#24
MULTICENTER STUDY
Yi Li, Xin Hou, Ruoyu Li, Kang Liao, Ling Ma, Xiaoming Wang, Ping Ji, Haishen Kong, Yun Xia, Hui Ding, Wei Kang, Ge Zhang, Jin Li, Meng Xiao, Yingxing Li, Yingchun Xu
BACKGROUND: Candida glabrata is an important cause of invasive candidiasis. Echinocandins are the first-line treatment of invasive candidiasis caused by C. glabrata. The epidemiological echinocandin sensitivity requires long-term surveillance and the understanding about whole genome characteristics of echinocandin non-susceptible isolates was limited. RESULTS: The present study investigated the echinocandin susceptibility of 1650 C. glabrata clinical isolates in China from August 2014 to July 2019...
November 16, 2023: BMC Microbiology
#25
REVIEW
Kaili Jiang, Pan Luo, Xinxin Wang, Ling Lu
Invasive fungal infections have increased remarkably, which have become unprecedented concern to human health. However, the effectiveness of current antifungal drugs is limited due to drug resistance and toxic side-effects. It is urgently required to establish the effective biosynthetic strategy for developing novel and safe antifungal molecules economically. Echinocandins become a promising option as a mainstay family of antifungals, due to specifically targeting the fungal specific cell wall. To date, three kinds of echinocandins for caspofungin, anidulafungin, and micafungin, which derived from pneumocandin B0 , echinocandin B, and FR901379, are commercially available in clinic and have shown potential in managing invasive fungal infections in a cost-effective manner...
October 26, 2023: Microbial Biotechnology
#26
JOURNAL ARTICLE
Jason A Roberts, Fekade Sime, Jeffrey Lipman, Maria Patricia Hernández-Mitre, João Pedro Baptista, Roger J Brüggemann, Jai Darvall, Jan J De Waele, George Dimopoulos, Jean-Yves Lefrant, Mohd Basri Mat Nor, Jordi Rello, Leonardo Seoane, Monica A Slavin, Miia Valkonen, Mario Venditti, Wai Tat Wong, Markus Zeitlinger, Claire Roger
OBJECTIVE: To describe whether contemporary dosing of antifungal drugs achieves therapeutic exposures in critically ill patients that are associated with optimal outcomes. Adequate antifungal therapy is a key determinant of survival of critically ill patients with fungal infections. Critical illness can alter an antifungal agents' pharmacokinetics, increasing the risk of inappropriate antifungal exposure that may lead to treatment failure and/or toxicity. DESIGN SETTING AND PARTICIPANTS: This international, multicentre, observational pharmacokinetic study will comprise adult critically ill patients prescribed antifungal agents including fluconazole, voriconazole, posaconazole, isavuconazole, caspofungin, micafungin, anidulafungin, and amphotericin B for the treatment or prophylaxis of invasive fungal disease...
March 2023: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
#27
JOURNAL ARTICLE
F F Wan, M Zhang, J Guo, W J Wu
Objective: To explore the epidemiological characteristics of sample distribution and antifungal susceptibilities of clinically invasive C. tropicalis isolates from 2017 to 2021 in East China. Methods: Using a retrospective analysis, the East China Invasive Fungal Infection Group (ECIFIG) collected C. tropicalis clinically isolated from 32 hospitals in East China between January 2017 and December 2021. The identification results of the strains were reviewed using mass spectrometry by the central laboratory of the Shanghai East Hospital...
October 6, 2023: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
#28
JOURNAL ARTICLE
Ronald G Hall, Shuhan Liu, William C Putnam, Rajareddy Kallem, Tawanda Gumbo, Manjunath P Pai
Echinocandins like anidulafungin are first-line therapies for candidemia and invasive candidiasis, but their dosing may be suboptimal in obese patients. Our objective was to quantify anidulafungin exposure in a cohort of adults across a wide body size range to test if body size affects anidulafungin pharmacokinetics (PK). We enrolled 20 adults between the ages of 18 and 80 years, with an equal distribution of patients above and below a body mass index of 30 kg/m2 . A single 100-mg dose of anidulafungin was administered, followed by intensive sampling over 72 h...
November 15, 2023: Antimicrobial Agents and Chemotherapy
#29
Kazem Amirizad, Mona Ghazanfari, Javad Javidnia, Mahdi Abastabar, Mohammad Taghi Haghi Ashtiani, Maryam Sotoudeh Anvari, Maryam Fathi, Amirreza Espahbodi, Hamid Badali, Mohammad Taghi Hedayati, Iman Haghani, Seyedmojtaba Seyedmousavi
BACKGROUND: Viral pneumonia such as COVID-19-associated aspergillosis could increase susceptibility to fungal super-infections in critically ill patients. METHODS: Here we report a pediatric case of Aspergillus quadrilineatus cerebral infection in a recently diagnosed COVID-19-positive patient underlying acute lymphocytic leukemia. Morphological, molecular methods, and sequencing were used to identify this emerging species. RESULTS: Histopathological examination showed a granulomatous necrotic area containing dichotomously branching septate hyphae indicating a presumptive Aspergillus structure...
October 5, 2023: Journal of Clinical Laboratory Analysis
#30
REVIEW
Andreas H Groll, Katharina Körholz, Malcolm Holterhus, Thomas Lehrnbecher
Invasive fungal diseases (IFDs) play an important role in the supportive care of paediatric patients with acute leukaemia and those undergoing allogeneic haematopoietic cell transplantation, and they are associated with significantly decreased overall survival rates in affected individuals. Relative to adults, children and adolescents are distinct in terms of host biology, predisposing conditions, presentation and epidemiology of fungal diseases, and in the pharmacology of antifungal agents. The paediatric development of antifungal agents has moved forward in a coordinated manner, and major advances have been made regarding concepts and recommendations for the prevention and treatment of IFDs...
January 2024: Mycoses
#31
JOURNAL ARTICLE
Brandon K Hawkins, Samantha D Walker, Mahmoud A Shorman
Significant increases in antibacterial use were observed during the COVID-19 pandemic. However, subsequent analyses found this increase in antibiotic use to be excessive in comparison with the relatively low rates of bacterial coinfection. Although patients who are critically ill with COVID-19 may be at an increased risk for pulmonary aspergillosis, antifungal use in these populations remained underreported, particularly in later phases of the pandemic. This single-center, population-level cohort analysis compares the monthly use rates of mold-active antifungal drugs in the medical intensive care unit during April 2019-March 2020 (baseline) with those during April 2020-November 2022...
August 23, 2023: Antibiotics
#32
JOURNAL ARTICLE
Elaine Cristina Francisco, Felipe de Camargo Ribeiro, João Nobrega Almeida Junior, Diego Betto Pedoni, Daniel Archimedes da Matta, Maribel Dolande, Analy Salles de Azevedo Melo, Ricardo Ferreira Lima, Valério Rodrigues Aquino, Dora E Corzo-León, Jeannete Zurita, Jorge Alberto Cortes, Marcio Nucci, Arnaldo Lopes Colombo
Members of the Meyerozyma guilliermondii species complex are able to cause superficial and life-threatening systemic infections with low susceptibility to azoles and echinocandins. We tested 130 bloodstream M. guilliermondii complex isolates collected from eight Latin American medical centers over 18 years (period 1 = 2000-2008 and period 2 = 2009-2018) to investigate trends in species distribution and antifungal resistance. The isolates were identified by rDNA ITS region sequencing, and antifungal susceptibility tests were performed against fluconazole, voriconazole, anidulafungin, and amphotericin B using the CLSI microbroth method...
September 12, 2023: Microbiology Spectrum
#33
JOURNAL ARTICLE
Wellington Fernandes da Silva, Fernanda Rodrigues Mendes, Raphael da Costa Bandeira de Melo, Elvira Deolinda Rodrigues Pereira Velloso, Vanderson Rocha, Eduardo Magalhaes Rego
INTRODUCTION: Invasive fungal infection (IFI) accounts for substantial morbidity during the treatment of acute myeloid leukemia (AML) in adults. Antifungal prophylaxis (AP) is needed during intensive chemotherapy, and posaconazole is not widely available. In this study, we aimed to examine the impact of prophylactic anidulafungin during intensive AML remission induction. METHODS: This is a retrospective cohort encompassing newly diagnosed AML adult patients. All subjects received intensive chemotherapy and were divided into three groups: patients who did not receive any AP and patients who received fluconazole (150-400 mg/day) or anidulafungin (100 mg/day)...
September 2, 2023: Journal de Mycologie Médicale
#34
REVIEW
Helmut J F Salzer
BACKGROUND: Invasive fungal infections caused by Candida or Aspergillus are associated with a high mortality. Knowledge about the risk factors, diagnosis and treatment management is crucial for improving the survival of those affected. OBJECTIVE: To give a practical overview about risk factors and treatment management of Candida and Aspergillus infections as well as providing an outlook on new antifungal agents. MATERIAL AND METHODS: Summary of the relevant literature and recommendations on candidemia and invasive candidiasis as well as invasive and chronic pulmonary aspergillosis...
September 2023: Medizinische Klinik, Intensivmedizin und Notfallmedizin
#35
JOURNAL ARTICLE
Judith Díaz-García, Marina Machado, Luis Alcalá, Elena Reigadas, Carlos Sánchez-Carrillo, Ana Pérez-Ayala, Elia Gómez-García de la Pedrosa, Fernando González-Romo, Paloma Merino, María Soledad Cuétara, Coral García-Esteban, Inmaculada Quiles-Melero, Nelly Daniela Zurita, María Muñoz-Algarra, María Teresa Durán-Valle, Gabriela Andrea Martínez-Quintero, Aída Sánchez-García, Patricia Muñoz, Pilar Escribano, Jesús Guinea, Aina Mesquida, Ana Gómez, Rosaura Pérez Muñoz, María Del Carmen Vera González, Elia Gómez-García De La Pedrosa, Fernando González Romo, Paloma Merino-Amador, Oscar Manuel Muñoz Clemente, Víctor Antón Berenguer, Oscar Cuevas Lobato, Guadalupe Bernal, Nelly Zurita, Ainhoa Gutiérrez Cobos, Isabel Sánchez Romero, Florinda San Juan Delgado, Yolanda Gil Romero, Arturo Manuel Fraile Torres
OBJECTIVES: Antifungal susceptibility testing is mostly conducted on blood-cultured Candida spp isolates. Since the intra-abdominal cavity has been highlighted as a hidden echinocandin-resistant C. glabrata reservoir, we assessed whether testing sequential isolates from a given patient might increase the chances of detecting antifungal resistance. METHODS: Intra-abdominal initial and sequential isolates from the same species from patients included in the CANDIMAD study (January 2019 to June 2022) were studied...
August 26, 2023: Clinical Microbiology and Infection
#36
JOURNAL ARTICLE
Laura N Silva, Lívia S Ramos, Simone S C Oliveira, Lucas B Magalhães, Jefferson Cypriano, Fernanda Abreu, Alexandre J Macedo, Marta H Branquinha, André L S Santos
Echinocandins, used for the prevention and treatment of invasive fungal infections, have led to a rise in breakthrough infections caused by resistant Candida species. Among these species, those belonging to the Candida haemulonii complex are rare multidrug-resistant (MDR) yeasts that are frequently misidentified but have emerged as significant healthcare-associated pathogens causing invasive infections. The objectives of this study were to investigate the evolutionary pathways of echinocandin resistance in C...
August 18, 2023: Journal of Fungi (Basel, Switzerland)
#37
JOURNAL ARTICLE
Huilin Su, Weiwei Jiang, Paul E Verweij, Li Li, Junhao Zhu, Jiande Han, Min Zhu, Shuwen Deng
INTRODUCTION: The emergence of resistance in Trichophyton rubrum to azoles and terbinafine has become increasingly evident in recent years, necessitating the development of novel antifungal drugs and the exploration of new indications for existing agents. METHODS: In this study, we retrospectively evaluated the in vitro antifungal activity of 3 echinocandins (anidulafungin, caspofungin, and micafungin) against 73 clinical isolates of T. rubrum collected from a teaching hospital in Shanghai, China, using EUCAST E...
2023: Infection and Drug Resistance
#38
Mohammad O Khalil, Laith A Ayasa, Anas Odeh, Husain Alawadhi
We present a case of a 57-year-old male patient with a history of prolonged intensive care unit (ICU) stay for coronavirus disease 2019 (COVID-19) who developed fungal spondylodiscitis, a rare complication. The patient initially presented complaining of respiratory symptoms and was subsequently treated with tocilizumab, remdesivir, enoxaparin, and dexamethasone. Following ICU discharge, he experienced recurrent infections, including extended-spectrum beta-lactamase Klebsiella urinary tract infection. Two months later, he developed back pain; magnetic resonance imaging (MRI) revealed inflammatory spondylodiscitis...
July 2023: Curēus
#39
JOURNAL ARTICLE
Huiping Lin, Jian Guo, Yueting Li, Chenlu Xiao, Liang Hu, Hui Chen, Xiuhai Lu, Wenjuan Wu
Aspergillus species is a widespread environmental mould that can cause aspergillosis. The purpose of this study was to investigate the antifungal susceptibility profile and genotypic characterization of clinical Aspergillus isolates from different provinces in Eastern China. The data included the antifungal susceptibility distributions with eight common antifungal drugs, cyp51A gene mutations of triazole-resistant A. fumigatus sensu stricto, and the genotypic relationships among the A. fumigatus sensu stricto isolates based on microsatellite typing...
August 14, 2023: Medical Mycology
#40
JOURNAL ARTICLE
Maiken Cavling Arendrup, Sevtap Arikan-Akdagli, Karin Meinike Jørgensen, Aleksandra Barac, Jörg Steinmann, Cristina Toscano, Valentina Arsic Arsenijevic, Assunta Sartor, Cornelia Lass Flörl, Axel Hamprecht, Tadeja Matos, Benedict R S Rogers, Inmaculada Quiles, Jochem Buil, Volkan Özenci, Robert Krause, Matteo Bassetti, Laura Loughlin, Blandine Denis, Anna Grancini, P Lewis White, Katrien Lagrou, Birgit Willinger, Riina Rautemaa-Richardson, Petr Hamal, Beyza Ener, Tugce Unalan-Altintop, Ebru Evren, Suleyha Hilmioglu-Polat, Yasemin Oz, Ozlem Koyuncu Ozyurt, Faruk Aydin, Filip Růžička, Eelco F J Meijer, Jean Pierre Gangneux, Deborah E A Lockhart, Nina Khanna, Clare Logan, Ulrike Scharmann, Guillaume Desoubeaux, Emmanuel Roilides, Alida Fe Talento, Karin van Dijk, Philipp Koehler, Jon Salmanton-García, Oliver A Cornely, Martin Hoenigl
The objectives of this study were to assess Candida spp. distribution and antifungal resistance of candidaemia across Europe. Isolates were collected as part of the third ECMM Candida European multicentre observational study, conducted from 01-07-2018 to 31-03-2022. Each centre (maximum number/country determined by population size) included ~10 consecutive cases. Isolates were referred to central laboratories and identified by morphology and MALDI-TOF, supplemented by ITS-sequencing when needed. EUCAST MICs were determined for five antifungals...
August 5, 2023: Journal of Infection
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
