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Anidulafungin

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https://www.readbyqxmd.com/read/29735833/echinocandins-their-role-in-the-management-of-candida-biofilms
#1
Subramanian Swaminathan, Shweta Kamat, Nalini Adele Pinto
The importance of antifungal agents and their clinical implications has received little attention in comparison to antibiotics, particularly in the health-care setting. However, apart from bacterial infections rising in hospitals, the incidences of fungal infections are growing with the development of resistance to conventional antifungal agents. Newer antifungal agents such as echinocandins (ECs) have been extensively studied over the past decade and are recognised as a superior treatment compared with prior antifungals as a first line of therapy in tertiary institutions...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29725811/genetic-diversity-and-antifungal-susceptibility-of-candida-parapsilosis-sensu-stricto-isolated-from-bloodstream-infections-in-turkish-patients
#2
Süleyha Hilmioğlu-Polat, Somayeh Sharifynia, Yasemin Öz, Müge Aslan, Nuray Gündoğdu, Ayşe Serin, Haleh Rafati, Faezeh Mohammadi, Dilek Yeşim-Metin, Aylin Döğen, Macit Ilkit, Seyedmojtaba Seyedmousavi
Candida parapsilosis sensu stricto is an emerging cause of hospital-acquired Candida infections, predominantly in southern Europe, South America, and Asia. We investigated the genetic diversity and antifungal susceptibility profile of 170 independent C. parapsilosis sensu stricto strains obtained from patients with candidemia who were treated at the Ege University Hospital in Izmir, Turkey, between 2006 and 2014. The identity of each strain was confirmed via PCR amplification and digestion of the secondary alcohol dehydrogenase-encoding gene...
May 3, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29712664/pharmacokinetics-of-anidulafungin-in-obese-and-normal-weight-adults
#3
Roeland E Wasmann, Rob Ter Heine, Eric P van Dongen, David M Burger, Vincent J Lempers, Catherijne A Knibbe, Roger J Brüggemann
In 2025, approximately one out of five adults will be obese. Physiological changes associated with obesity have shown to influence the pharmacokinetics of drugs. Anidulafungin is frequently used in critically ill patients and to achieve optimal efficacy it is essential that its dose is appropriate for each patients' characteristics. We combined data from obese subjects with data from normal-weight subjects and determined an optimal dosing regimen for obese patients by population-PK modeling.Twenty adults, of which twelve were normal-weight healthy subjects (median weight 67...
April 30, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29712651/resistance-to-echinocandins-in-candida-can-be-detected-by-performing-the-etest-directly-on-blood-culture-samples
#4
María Ángeles Bordallo-Cardona, Laura Judith Marcos-Zambrano, Carlos Sánchez-Carrillo, Emilio Bouza, Patricia Muñoz, Pilar Escribano, Jesús Guinea
Background: We examined the rapid evaluation of susceptibility to echinocandins in Candida spp. using the Etest performed directly on positive blood cultures and anidulafungin-containing agar plates. Methods: We prospectively collected 80 positive blood cultures (Bactec™-FX system, Becton-Dickinson, Cockeysville, Maryland, USA) with echinocandin-susceptible Candida spp (n=60) and echinocandin-intermediate C. parapsilosis (n=20) from patients with candidemia. Additionally, blood culture bottles of nonfungemic/bacteremic patients were spiked with 35 echinocandin-resistant Candida spp...
April 30, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29642828/-comparison-of-clinical-laboratory-standards-institute-clsi-and-european-committee-on-antimicrobial-susceptibility-testing-eucast-broth-microdilution-methods-for-determining-the-susceptibilities-of-candida-isolates
#5
Burcu Dalyan Cilo, Tuncay Topaç, Harun Ağca, Sezcan Sağlam, Kadir Efe, Beyza Ener
Candida species are among the top 10 pathogens causing bloodstream infections associated with high morbidity, mortality. In spite of the development of new antifungal drugs, epidemiological studies have shown that resistance to antifungal drugs among Candida isolates is becoming a serious problem. The aim of this study was to compare the antifungal broth microdilution methods of the Clinical and Laboratory Standards Institute (CLSI) and European Committee on Antimicrobial Susceptibility Testing (EUCAST) for amphotericin B, fluconazole, itraconazole, voriconazole, posaconazole and anidulafungin susceptibility of Candida blood isolates...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29610199/absence-of-azole-or-echinocandin-resistance-in-candida-glabrata-isolates-in-india-despite-background-prevalence-of-strains-with-defects-in-dna-mismatch-repair-pathway
#6
Ashutosh Singh, Kelley R Healey, Priyanka Yadav, Gargi Upadhyaya, Neelam Sachdeva, Smita Sarma, Anil Kumar, Bansidhar Tarai, David S Perlin, Anuradha Chowdhary
Candida glabrata infections are increasing world-wide and exhibit greater rates of antifungal resistance than other species. DNA mismatch repair (MMR) gene deletions, such as msh2Δ , in C. glabrata resulting in a mutator phenotype has recently been reported to facilitate rapid acquisition of antifungal resistance. This study determined the antifungal susceptibility profile of 210 C. glabrata isolates, in 10 hospitals in India and investigated the impact of novel MSH 2 polymorphisms on mutation potential. No echinocandin or azole resistant strains were detected among C...
April 2, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29572043/bioluminescence-imaging-increases-in-vivo-screening-efficiency-for-antifungal-activity-against-device-associated-candida-albicans-biofilms
#7
Greetje Vande Velde, Soňa Kucharíková, Patrick Van Dijck, Uwe Himmelreich
Fungal infections are a major problem for a growing number of mostly immune-compromised patients. Candida albicans is an important human fungal pathogen causing mucosal and deep tissue infections of which the majority is associated with biofilm formation on medical implants. The animal models that are currently in use to test antifungal drugs are limited to ex vivo analyses, requiring host sacrifice that excludes longitudinal monitoring of dynamic processes during biofilm formation in the live host. As a solution, we introduce non-invasive, dynamic imaging and quantification of C...
March 20, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29536323/susceptibility-profile-of-echinocandins-azoles-and-amphotericin-b-against-yeast-phase-of-talaromyces-marneffei-isolated-from-hiv-infected-patients-in-guangdong-china
#8
H-L Lei, L-H Li, W-S Chen, W-N Song, Y He, F-Y Hu, X-J Chen, W-P Cai, X-P Tang
Talaromyces marneffei (T. marneffei) can cause talaromycosis, a fatal systemic mycosis, in patients with AIDS. With the increasing number of talaromycosis cases in Guangdong, China, we aimed to investigate the susceptibility of 189 T. marneffei clinical strains to eight antifungal agents, including three echinocandins (anidulafungin, micafungin, and caspofungin), four azoles (posaconazole, itraconazole, voriconazole, and fluconazole), and amphotericin B, with determining minimal inhibition concentrations (MIC) by Sensititre YeastOne™ YO10 assay in the yeast phase...
March 13, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29530844/potent-activities-of-luliconazole-lanoconazole-and-eight-comparators-against-molecularly-characterized-fusarium-species
#9
Mahdi Abastabar, Abdullah M S Al-Hatmi, Mohammad Vafaei Moghaddam, G Sybren de Hoog, Iman Haghani, Seyed Reza Aghili, Tahereh Shokohi, Mohammad Taghi Hedayati, Roshanak Daie Ghazvini, Reza Kachuei, Ali Rezaei-Matehkolaei, Koichi Makimura, Jacques F Meis, Hamid Badali
A collection of clinical ( n = 47) and environmental ( n = 79) Fusarium isolates were tested against 10 antifungal drugs, including 2 novel imidazoles. Luliconazole and lanoconazole demonstrated very low geometric mean MIC values of 0.005 and 0.013 μg/ml, respectively, compared with 0.51 μg/ml for micafungin, 0.85 μg/ml for efinaconazole, 1.12 μg/ml for natamycin, 1.18 μg/ml for anidulafungin, 1.31 μg/ml for voriconazole, 1.35 μg/ml for caspofungin, 1.9 μg/ml for amphotericin B, and 4.08 μg/ml for itraconazole...
May 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29488180/first-report-of-candida-bracarensis-in-mexico-hydrolytic-enzymes-and-antifungal-susceptibility-pattern
#10
Rogelio de J Treviño-Rangel, José F Espinosa-Pérez, Hiram Villanueva-Lozano, Alexandra M Montoya, Angel Andrade, Alexandro Bonifaz, Gloria M González
Candida bracarensis is an emerging cryptic species within the Candida glabrata clade. To date, little is known about its epidemiology, virulence, and antifungal susceptibility. This study documents the occurrence of C. bracarensis for the first time in Mexico and focuses on its in vitro production of hydrolytic enzymes, as well as antifungal susceptibility to echinocandins. This strain was isolated from a vaginal swab of a female with vulvovaginal candidosis; exhibited a very strong activity of aspartyl proteinase, phospholipase, and hemolysin; and was susceptible to caspofungin, anidulafungin, and micafungin (MIC = 0...
February 27, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29486356/rezafungin-cd101-a-next-generation-echinocandin-a-systematic-literature-review-and-assessment-of-possible-place-in-therapy
#11
Amelia K Sofjan, Ardath Mitchell, Dhara N Shah, Tam Nguyen, Mui Sim, Ashley Trojcak, Nicholas D Beyda, Kevin W Garey
BACKGROUND: Rezafungin (CD101) is a novel echinocandin currently under development. The purpose of this study was to perform a systematic literature review of published evidence on CD101 and an antimicrobial stewardship audit of real-world use of echinocandins to determine areas of unmet medical need and potential places in therapy for rezafungin. METHODS: A systematic literature review on rezafungin identified eight peer-reviewed manuscripts and 19 separate abstracts...
February 24, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29463544/gene-expression-of-pneumocystis-murina-after-treatment-with-anidulafungin-results-in-strong-signals-for-sexual-reproduction-cell-wall-integrity-and-cell-cycle-arrest-indicating-a-requirement-for-ascus-formation-for-proliferation
#12
Melanie T Cushion, Alan Ashbaugh, Keeley Hendrix, Michael J Linke, Nikeya Tisdale, Steven G Sayson, Aleksey Porollo
The echinocandins are a class of antifungal agents that target β-1,3-d-glucan (BG) biosynthesis. In the ascigerous Pneumocystis species, treatment with these drugs depletes the ascus life cycle stage, which contains BG, but large numbers of forms which do not express BG remain in the infected lungs. In the present study, the gene expression profiles of Pneumocystis murina were compared between infected, untreated mice and mice treated with anidulafungin for 2 weeks to understand the metabolism of the persisting forms...
May 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29463527/a-new-marker-of-echinocandin-activity-in-an-in-vitro-pharmacokinetic-pharmacodynamic-model-correlates-with-an-animal-model-of-aspergillus-fumigatus-infection
#13
Joseph Meletiadis, Maria Siopi, Athanassios Tsakris, Johan W Mouton, Spyros Pournaras
The lack of a quantifiable marker for echinocandin activity hinders in vitro pharmacokinetic/pharmacodynamic (PK/PD) studies for Aspergillus spp. We developed an in vitro PK/PD model simulating the pharmacokinetics of anidulafungin and assessing its pharmacodynamics against Aspergillus fumigatus with a new, easily quantifiable, sensitive, and reproducible marker. Two clinical A. fumigatus isolates previously used in animals (AZN8196 and V52-35) with identical anidulafungin EUCAST (0.03 μg/ml) and CLSI (0.015 μg/ml) minimal effective concentrations (MEC) and one isolate (strain AFU79728) with an MEC of >16 μg/ml were tested in a two-compartment PK/PD dialysis/diffusion closed model containing a dialysis membrane (DM) tube inoculated with 103 CFU/ml...
May 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29439960/anidulafungin-pharmacokinetics-in-ascites-fluid-and-pleural-effusion-of-critically-ill-patients
#14
R Welte, P Eller, I Lorenz, M Joannidis, R Bellmann
Anidulafungin concentrations were quantified with high-pressure liquid chromatography (HPLC) and UV detection of the ascites fluid and pleural effusion of 10 adult critically ill patients. Samples were collected from ascites fluid and from pleural drains or during paracentesis and thoracentesis, respectively. Anidulafungin levels in ascites fluid (0.12 to 0.99 μg/ml) and in pleural effusion (0.32 to 2.02 μg/ml) were below the simultaneous levels in plasma (1.04 to 7.70 and 2.48 to 13.36 μg/ml, respectively) and below the MIC values for several pathogenic Candida strains...
April 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29416360/clinical-characteristics-of-the-first-cases-of-invasive-candidiasis-in-china-due-to-pan-echinocandin-resistant-candida-tropicalis-and-candida-glabrata-isolates-with-delineation-of-their-resistance-mechanisms
#15
Meng Xiao, Xin Fan, Xin Hou, Sharon Ca Chen, He Wang, Fanrong Kong, Zi-Yong Sun, Yun-Zhuo Chu, Ying-Chun Xu
Echinocandin antifungal agents have become the first-line therapy for invasive candidiasis (IC) in many countries. Despite their increasing use, resistance to this class of drug is, overall, still uncommon. Here, we report two patients from the People's Republic of China with IC, one with infection caused by pan-echinocandin-resistant Candida tropicalis and the other by pan-echinocandin-resistant Candida glabrata . We also describe the mechanisms of drug resistance of these isolates. The echinocandin-resistant C...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29383574/a-fatal-case-of-candida-auris-and-candida-tropicalis-candidemia-in-neutropenic-patient
#16
Ratna Mohd Tap, Teck Choon Lim, Nur Amalina Kamarudin, Stephanie Jane Ginsapu, Mohd Fuat Abd Razak, Norazah Ahmad, Fairuz Amran
We report a fatal case of Candida auris that was involved in mixed candidemia with Candida tropicalis, isolated from the blood of a neutropenic patient. Identification of both isolates was confirmed by amplification and sequencing of internal transcribed spacer and D1/D2 domain of large subunit in rRNA gene. Antifungal susceptibility test by E-test method revealed that C. auris was resistant to amphotericin B, anidulafungin, caspofungin, fluconazole, itraconazole and voriconazole. On the other hand, C. tropicalis was sensitive to all antifungal tested...
January 30, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29371534/activity-of-amphotericin-b-and-anidulafungin-combined-with-rifampicin-clarithromycin-ethylenediaminetetraacetic-acid-n-acetylcysteine-and-farnesol-against-candida-tropicalis-biofilms
#17
Marcelo Ernesto Fernández-Rivero, José L Del Pozo, Amparo Valentín, Araceli Molina de Diego, Javier Pemán, Emilia Cantón
We evaluated the activity of (1) amphotericin-B (AMB), combined with rifampicin (RIF), clarithromycin (CLA), N -acetylcysteine (NAC), ethylenediaminetetraacetic acid (EDTA), and farnesol (FAR) (1000, 1000, 1000, 4000, and 30,000 mg/L, and 300 µM, respectively), against Candida tropicalis biofilms formed on polytetrafluoroethylene (PTFE) and (2) anidulafungin (ANF) combined with the same compounds at 8, 10, 5, 40, and 30 mg/L, and 30 µM, respectively, against biofilms formed on titanium. Biofilm growth kinetics were performed in a CDC Biofilm Reactor (CBR)...
March 22, 2017: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29339229/a-rare-case-of-candida-glabrata-spondylodiscitis-case-report-and-literature-review
#18
REVIEW
Manfredi Gagliano, Costanza Marchiani, Giulia Bandini, Paolo Bernardi, Nicolas Palagano, Elisa Cioni, Martina Finocchi, Silvia Bellando Randone, Alberto Moggi Pignone
BACKGROUND: Spondylodiscitis is an infection of the vertebral column, the incidence of which is increasing due to an increase in the susceptible population and improved ascertainment. This disease has been associated with a wide range of microorganisms. Fungal spondylodiscitis is uncommon (0.5-1.6%) and strongly associated with immunosuppression and diabetes (Gouliouris et al., 2010). A rare case of Candida glabrata spondylodiscitis in a non-neutropenic diabetic patient is reported herein, along with a review of the literature...
March 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29311065/-in-vitro-and-in-vivo-evaluation-of-the-antifungal-activity-of-apx001a-apx001-against-candida-auris
#19
Christopher L Hager, Emily L Larkin, Lisa Long, Fatima Zohra Abidi, Karen J Shaw, Mahmoud A Ghannoum
Candida auris is an emerging multidrug-resistant yeast that has been responsible for invasive infections associated with high morbidity and mortality. C. auris strains often demonstrate high fluconazole and amphotericin B MIC values, and some strains are resistant to all three major antifungal classes. We evaluated the susceptibility of 16 C. auris clinical strains, isolated from a wide geographical area, to 10 antifungal agents, including APX001A, a novel agent that inhibits the fungal protein Gwt1 (glycosylphosphatidylinositol-anchored wall transfer protein 1)...
March 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29311063/mutant-prevention-concentration-and-mutant-selection-window-of-micafungin-and-anidulafungin-in-clinical-candida-glabrata-isolates
#20
María Ángeles Bordallo-Cardona, Laura Judith Marcos-Zambrano, Carlos Sánchez-Carrillo, Elia Gómez G de la Pedrosa, Rafael Cantón, Emilio Bouza, Pilar Escribano, Jesús Guinea
We report the mutant prevention concentration (MPC) and mutant selection window (MSW) for micafungin and anidulafungin administered to treat Candida glabrata We also determine the mutation frequency. We studied 20 echinocandin-susceptible, fluconazole-intermediate, and FKS wild-type C. glabrata isolates. Adjusted inocula were stroked directly onto Sabouraud agar plates containing different concentrations of micafungin or anidulafungin and visually inspected daily for up to 5 days of incubation. Individual colonies growing on the plates containing echinocandins at 1 mg/liter were selected for antifungal susceptibility testing...
March 2018: Antimicrobial Agents and Chemotherapy
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