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https://www.readbyqxmd.com/read/28932071/keratosis-follicularis-spinulosa-decalvans-with-associated-mental-retardation-response-to-isotretinoin
#1
Sarita Sanke, Vibhu Mendiratta, Archana Singh, Ram Chander
No abstract text is available yet for this article.
July 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28932054/darier-disease-a-rare-genodermatosis
#2
Hema Suryawanshi, Akshay Dhobley, Aparna Sharma, Pramod Kumar
Darier disease (DD), also known as keratosis follicularis or dyskeratosis follicularis, is a rare autosomal dominant genodermatosis with high penetrance and variable expressivity. It is caused by mutations of ATP2A2 gene which encodes the sarco/endoplasmic reticulum Ca(2+) ATPase isoform 2. It is clinically manifested by hyperkeratotic papules primarily affecting seborrheic areas on the head, neck and thorax, with less frequent involvement of the oral mucosa. When oral manifestations are present, they primarily affect the palatal and alveolar mucosa, are usually asymptomatic and are discovered in routine dental examination...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28931194/intracapsular-tonsillectomy-for-keratosis-pharyngeous-a-pilot-study-of-postoperative-recovery-and-surgical-efficacy
#3
Philip A Gaudreau, Eric M Gessler
Our objective was to perform a pilot study comparing intracapsular radiofrequency ablation tonsillectomy with subcapsular tonsillectomy in adult patients with keratosis pharyngeous. Patients diagnosed with keratosis pharyngeous between December 2010 and February 2013 were randomized to undergo either intracapsular or subcapsular tonsillectomy using radiofrequency ablation. Postoperative pain scores and amount of pain medication taken were recorded for 2 weeks. A 6-month follow-up questionnaire was used to assess efficacy of the procedure...
September 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28929057/keratosis-obturans-a-disease-of-the-tropics
#4
A W Chong, R Raman
Keratosis obturans appears to be an obscure and relatively uncommon entity, even in literature search of journals and reference texts, so much so that there is not even any prevalence or incidence statistics available. However, the condition did not appear to be as uncommon based on our clinical observations. We have managed to obtain 64 patients representing 67 ears with keratosis obturans in our study period of about 18 months with a pattern of occurrence during this period. Humid weather seemed to play a role in the frequency of its appearance during certain period in our observation...
September 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28925390/alterations-of-micrornas-throughout-the-malignant-evolution-of-cutaneous-squamous-cell-carcinoma-the-role-of-mir-497-in-epithelial-to-mesenchymal-transition-of-keratinocytes
#5
A Mizrahi, A Barzilai, D Gur-Wahnon, I Z Ben-Dov, S Glassberg, T Meningher, E Elharar, M Masalha, J Jacob-Hirsch, H Tabibian-Keissar, I Barshack, J Roszik, R Leibowitz-Amit, Y Sidi, D Avni
Skin carcinogenesis is known to be a multi-step process with several stages along its malignant evolution. We hypothesized that transformation of normal epidermis to cutaneous squamous cell carcinoma (cSCC) is causally linked to alterations in microRNAs (miRNA) expression. For this end we decided to evaluate their alterations in the pathologic states ending in cSCC. Total RNA was extracted from formalin fixed paraffin embedded biopsies of five stages along the malignant evolution of keratinocytes towards cSCC: Normal epidermis, solar elastosis, actinic keratosis KIN1-2, advanced actinic keratosis KIN3 and well-differentiated cSCC...
September 18, 2017: Oncogene
https://www.readbyqxmd.com/read/28925042/clinical-comparison-of-actinic-changes-preceding-squamous-cell-carcinoma-vs-intraepidermal-carcinoma-in-renal-transplant-recipients
#6
Z Jiyad, P O'Rourke, H P Soyer, A C Green
Intraepidermal carcinoma (IEC) is a type of in situ squamous cell carcinoma (SCC), although progression of IEC is rare. We sought to investigate differences between the actinic skin changes preceding the development of both SCC and IEC. Photographs of 63 skin sites at which either SCC or IEC subsequently developed in 37 renal transplant recipients (RTRs) were examined for features of actinic change. We found that areas of skin with an actinic keratosis (AK) > 1 cm(2) in size were four times more likely to develop SCC as opposed to IEC (OR = 4...
September 19, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28920109/papillon-lef%C3%A3-vre-syndrome-a-series-of-three-cases-in-the-same-family-and-a-literature-review
#7
Jasbir D Upadhyaya, Dustin Pfundheller, Mohammed N Islam, Indraneel Bhattacharyya
Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive disorder that exhibits palmoplantar keratosis and early severe periodontitis. The oral disease affects both the primary and permanent dentitions leading to premature exfoliation of teeth. Various etiologic factors, such as genetic mutations, immunologic alterations, and bacteria have been implicated in PLS. Genetic mutations leading to the loss of function of cathepsin C (CTSC) gene, located on chromosome 11q14, is considered pivotal in this condition...
2017: Quintessence International
https://www.readbyqxmd.com/read/28917462/human-papilloma-virus-expression-in-immunocompetent-patients-with-actinic-keratosis-a-case-series
#8
Caterina Dianzani, Francesca Paolini, Claudio Conforti, Elisabetta Riva, Emanuela Beninati, Aldo Venuti
No abstract text is available yet for this article.
October 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28916031/dermatosis-papulosa-nigra-a-clinically-and-histopathologically-distinct-entity
#9
Simon Arda Metin, Brian W Lee, William Clark Lambert, Lawrence Charles Parish
Dermatosis papulosa nigra was first described by Aldo Castellani (1874-1971) more than 90 years ago, and it has since been presumed to be a variant of seborrheic keratosis. Despite their morphologic similarities both macroscopically and microscopically, key differences have yet to be explained. These lesions also exhibit different demographics, with dermatosis papulosa nigra having a predilection for dark-skinned individuals and a female predominance. No studies to date have investigated this, but studies assessing the mechanisms of similar dermatologic conditions may yield significant clues...
September 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28915278/differential-diagnosis-of-seborrheic-keratosis-clinical-and-dermoscopic-features
#10
Ralph P Braun, Sabine Ludwig, Ashfaq A Marghoob
<p>Seborrheic keratosis (SK) is a benign epidermal keratinocytic tumor that is extremely common, particularly in individuals over the age of 50. Most individuals with SK will have more than one lesion and the presence of over 10 lesions in the same person is not uncommon. Although the clinical morphology of most SK with their stuck-on, symmetric, keratotic, and waxy appearance makes them easy to identify, many manifest a morphology resembling melanoma or squamous cell carcinoma. One can argue that such cases will ultimately not prove to be problematic since a simple biopsy will easily reveal their benign nature and eliminate any concerns...
September 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28913302/eccrine-poroma-of-the-postauricular-area
#11
Hyun Rok Lee, Gyu Yong Jung, Hea Kyeong Shin, Dong Lark Lee, Jong Im Lee, Jung Hwan Kim
Eccrine poroma is a common benign cutaneous tumor that originates in an intraepidermal eccrine duct. This tumor exhibits acral distribution (sole, palm), and is rarely encountered in the head and neck area. In fact eccrine poroma in the postauricular area has only been rarely reported. A 55-year-old female visited our hospital with a main complaint of a mass that first developed in the left postauricular area about a year previously. The mass was painless, soft, protruding, domed, and dark red in color, and had slowly enlarged (at presentation it measured 1×1 cm)...
March 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28906092/prevalence-of-actinic-keratosis-in-a-french-cohort-of-elderly-people-the-proof-study
#12
Elisa Cinotti, Jean L Perrot, Bruno Labeille, Amandine Mora Gues, Christelle Chol, Amaury Leclerq, Cécile Jaffelin, Anne C Biron, Jean C Barthélémy, Frédéric Cambazard
No abstract text is available yet for this article.
October 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28905836/rare-ocular-manifestations-in-keratosis-follicularis-darier-white-disease
#13
Savitha H Kanakpur, Divya Upendra Caculo
Keratosis follicularis (Darier's disease) is a rare (1 in 30,000-100,000) genetic autosomal-dominant predominantly dermatological disorder characterized by hyperkeratosis and acantholysis due to a defective calcium transport in the cells. Ocular findings, if present, are very rare in this condition. Here, we are reporting a case of keratosis follicularis (Darier's disease) with ocular manifestations that have not been reported so far to the best of our knowledge.
September 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28902028/a-101-a-proprietary-topical-formulation-of-high-concentration-hydrogen-peroxide-solution-a-randomized-double-blind-vehicle-controlled-parallel-group-study-of-the-dose-response-profile-in-subjects-with-seborrheic-keratosis-of-the-face
#14
Janet C DuBois, Michael Jarratt, Brian B Beger, Mark Bradshaw, Christopher V Powala, Stuart D Shanler
BACKGROUND: Seborrheic keratosis (SK) is a common benign skin tumor, yet no topical treatments are approved in the United States. OBJECTIVE: To evaluate the proprietary, stabilized, high-concentration hydrogen peroxide-based topical solution A-101 (32.5% and 40% concentrations) for treatment of facial SK lesions. MATERIALS AND METHODS: In this multicenter, double-blind, vehicle-controlled study, eligible subjects were randomly assigned to receive up to 2 treatments of A-101 40%, A-101 32...
September 4, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28902026/chemical-peels-indications-and-special-considerations-for-the-male-patient
#15
Jeave Reserva, Amanda Champlain, Seaver L Soon, Rebecca Tung
BACKGROUND: Chemical peels are a mainstay of aesthetic medicine and an increasingly popular cosmetic procedure performed in men. OBJECTIVE: To review the indications for chemical peels with an emphasis on performing this procedure in male patients. MATERIALS AND METHODS: Review of the English PubMed/MEDLINE literature and specialty texts in cosmetic dermatology, oculoplastic, and facial aesthetic surgery regarding sex-specific use of chemical peels in men...
September 4, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28869804/erosive-pustular-dermatosis-of-the-scalp-and-kindler-syndrome-a-new-association
#16
L Atzori, M Lai, A Lappi, M A Brundu, F Rongioletti
Erosive pustular dermatosis of the scalp (EPDS) is a rare inflammatory disease that predominantly affects elderly people, with a chronic course and long-term management.(1) Sterile pustules, superficial erosions and crusted lesions on atrophic skin, resulting in cicatricial alopecia, characterize the typical clinical presentation. (1-3) Triggering factors include several drugs, actinic damage, local trauma, surgery, and physical or chemical procedures for actinic keratosis.(4-6) To the best of our knowledge, no previous association with Kindler syndrome was found in the literature...
September 4, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28859143/the-effect-of-wool-hydrolysates-on-squamous-cell-carcinoma-cells-in-vitro-possible-implications-for-cancer-treatment
#17
Tatsiana Damps, Anna Katarzyna Laskowska, Tomasz Kowalkowski, Monika Prokopowicz, Anna Katarzyna Puszko, Piotr Sosnowski, Joanna Czuwara, Marek Konop, Krzysztof Różycki, Joanna Karolina Borkowska, Aleksandra Misicka, Lidia Rudnicka
Squamous cell carcinoma of the skin is the second most common cutaneous malignancy. Despite various available treatment methods and advances in noninvasive diagnostic techniques, the incidence of metastatic cutaneous squamous cell carcinoma is rising. Deficiency in effective preventive or treatment methods of transformed keratinocytes leads to necessity of searching for new anticancer agents. The present study aims to evaluate the possibility of using wool hydrolysates as such agents. Commercially available compounds such as 5-fluorouracil, ingenol mebutate, diclofenac sodium salt were also used in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28858927/clinical-and-histologic-evaluation-of-ingenol-mebutate-0-015-gel-for-the-cosmetic-improvement-of-photoaged-skin
#18
Marc Z Handler, Bradley S Bloom, David J Goldberg
BACKGROUND: No studies have examined the use of topical ingenol mebutate for improvement of photoaged skin. OBJECTIVE: To evaluate clinical results of ingenol mebutate gel applied to photoaged skin and to quantify improvement at 7, 30, and 60 days after application. MATERIALS AND METHODS: Twenty-five subjects were enrolled in the study. Picato (ingenol mebutate) (LEO Pharma, Parsippany, NJ) gel was applied to an area with a known actinic keratosis daily for 3 days...
August 30, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28857272/acanthoma-planoepitheliale-hyperkeratoticum-lesions-associated-with-braf-inhibitor-in-metastatic-melanoma
#19
M Sokołowska-Wojdyło, B Olszewska, M Sobjanek, M Sławińska, K Sosińska-Mielcarek, W Biernat, R Nowicki
A 68-year-old woman was diagnosed with BRAF V600 mutation positive melanoma of unknown primary (MUP) with metastasis to the lung, liver and brain. According to local standards dabrafenib monotherapy was started in July 2016. Control CT performed after two months revealed disease stabilization. The tolerance of therapy was good, but after 2 months of treatment with dabrafenib the patient developed disseminated skin lesions with extended seborrheic keratosis G2 (according to international common toxicity criteria CTC)...
August 30, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28853982/outcomes-of-two-surgical-techniques-for-major-trichiasis-treatment
#20
Lucieni Cb Ferraz, Roberta Lrs Meneghim, Alicia Galindo-Ferreiro, Ana Cv Wanzeler, Michelli M Saruwatari, Larissa H Satto, Carlos R Padovani, Silvana A Schellini
The purpose of this article is to analyze the outcomes of two surgical techniques to treat major trichiasis. A retrospective chart review of 67 patients (89 eyelids) with major trichiasis was performed who underwent surgical treatment using one of two techniques: intermarginal split lamella with graft (ISLG group) or lid lamella resection (LLR group). There were 30 lids in the ISLG group with mean patient age of 71.8 years and 63.3% were females. There were 59 lids in the LLR group with mean patient age of 72...
August 30, 2017: Orbit
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