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https://www.readbyqxmd.com/read/29033821/certolizumab-pegol-induced-folliculitis-like-lichenoid-sarcoidosis-in-a-patient-with-rheumatoid-arthritis
#1
Hiroyuki Sakai, Wakana Nomura, Motoshi Sugawara
Anti-tumor necrosis factor α (TNF-α) biologic agents are used for treating refractory sarcoidosis. However, sarcoidosis-like epithelioid cell granulomas may develop during anti-TNF-α treatment. A 63-year-old man suffering from rheumatoid arthritis was treated with oral methotrexate and methylprednisolone for 4 years. He subsequently started biweekly subcutaneous injections of certolizumab pegol. Three months later, light red follicular papules developed on his chest and they spread over the trunk and bilateral upper arms...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29033813/recurrence-of-melanoma-after-starting-apremilast-for-psoriasis
#2
Thomas G Salopek
This is a report on a 32-year-old man with a history of two previous melanomas with concurrent plaque-type psoriasis. His history dates to 2009, when he was diagnosed with his first melanoma on the right occiput, Clark's level IV, tumor thickness 1.53 mm, nonulcerated, mitotic index 1/mm(2). He subsequently developed nodal recurrence after an initial negative sentinel lymph node biopsy and was treated with complete lymph node dissection. In 2012, he was diagnosed with a second primary melanoma on the right upper chest, Clark's level IV, tumor thickness 0...
May 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29028823/novel-mutations-in-darier-disease-and-association-to-self-reported-disease-severity
#3
Ivone U S Leong, Alexander Stuckey, Tara Ahanian, Martin Cederlöf, Jakob D Wikstrom
Darier disease is a rare and severe autosomal dominant skin disease characterised by malodorous keratotic papules in seborrheic areas of the skin. Darier disease affects up to 1 in 30 000 people and is caused by mutations in the ATP2A2 gene, which encodes to the sarco/endoplasmic reticulum calcium-ATPase isoform 2 that pumps calcium into the endoplasmic reticulum. Although many ATP2A2 variants have been described, it is not known if genotype correlates with phenotype, which could be important for prognosis and treatment...
2017: PloS One
https://www.readbyqxmd.com/read/29027009/lipid-lowering-agent-triggered-dermatomyositis-and-polymyositis-a-case-series-and-literature-review
#4
REVIEW
Isabela Bruna Pires Borges, Marilda Guimarães Silva, Rafael Giovane Misse, Samuel Katsuyuki Shinjo
Lipid-lowering agent-triggered dermatomyositis (DM) or polymyositis (PM) is a rare event. Therefore, the aim of the present study was to describe a series of such cases. A retrospective cohort study of 5 DM and 4 PM cases triggered by prior exposure to lipid-lowering agents between 2001 and 2017 was carried out. All patients, except for two cases, had muscle biopsy compatible with inflammatory myopathy and no serum autoantibodies positive for anti-SRP or anti-HMGCoAR. Median age of the patients at time of diagnosis was 68 years...
October 12, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29026548/erythromelanosis-follicularis-faciei-et-colli-with-reticulated-hyperpigmentation-of-the-extremities
#5
Fahad Mohammad Al-Saif, Abdullah Ali Baqays, Hadeel Fahad AlSaif, Ahmed Abdullah Alhumidi
Erythromelanosis follicularis faciei et colli (EFFC) is a distinct, rare, and underdiagnosed condition of unknown etiology that is characterized by well-demarcated erythema, hyperpigmentation, and follicular papules. The pigmentation is usually on both maxillary, preauricular regions, and the cheeks. We report a case of a 12-year-old boy with EFFC that was associated with reticulated pigmentation of the extremities.
October 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29026476/tenofovir-induced-leukocytoclastic-vasculitis
#6
Said A Al-Busafi, Abdulatif Al-Suleimani, Aysha Al-Hamadani, Wasif Rasool
Tenofovir, a nucleotide analog, is one of the first-line medications recommended for the treatment of active chronic hepatitis B virus infection (CHB) and as a primary prophylaxis to prevent hepatitis B reactivation in cases of immunosuppression. We report the first case of tenofovir-induced leukocytoclastic vasculitis (LCV). A 43-year-old obese woman, who was known to have inactive CHB, was diagnosed with chronic immune thrombocytopenic purpura (ITP). She was treated with corticosteroid therapy and was put on tenofovir to prevent hepatitis B virus reactivation...
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29024536/etanercept-induced-lymphocytic-infiltration-of-jessner-kanof
#7
Noémie Abbad, Tristan Lanal, Céline Brenuchon, Gauthier Morel, Xavier Deprez
The patient, a 52-year-old man presented a two-week history of asymptomatic multiple erythematous papules on the upper back (Panel A). The skin lesion had arisen 3 weeks after starting therapy with etanercept for axial spondyloarthritis. For several months, the patient had been taking NSAI and tramadol. A biopsy specimen from a lesion revealed a dense lymphocytic infiltrate of the superficial and mid-dermis (arrow) with perivascular and perifollicular distribution (Panel B). This article is protected by copyright...
October 12, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29023980/agminated-segmental-plaque-type-blue-nevus-associated-with-hypertrichosis-and-soft-tissue-hypertrophy-report-of-a-case-and-review-of-the-literature
#8
Manrup K Hunjan, Desiree Mohandas, Alina G Bridges, Megha Tollefson
Blue nevi are common skin neoplasms that typically present as asymptomatic solitary papules, although they may rarely occur in an agminated configuration. We describe a case of agminated blue nevus in a segmental facial distribution associated with soft tissue hypertrophy and hypertrichosis in a 16-year-old boy and present a review of the literature. Although they are generally considered to be benign, concurrent soft tissue changes occurring within an agminated blue nevus should be investigated thoroughly to exclude alternate diagnoses...
October 11, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29019823/from-classical-to-unusual-report-on-5-cases-of-transient-reactive-aquagenic-pseudokeratoderma-and-review-of-the-literature
#9
Adriana Guadalupe Peña-Romero, Sonia Toussaint-Caire, Yann Charli-Joseph, Fernando Dela Barreda-Becerril, Judith Domínguez-Cherit
Transient reactive aquagenic pseudokeratoderma is characterized by transient whitish and translucent papules after water exposure in palms and soles. We report 5 additional cases and their histopathologic features. Patient 5 showed a topography that had not been reported before; this demonstrates that it is not an exclusive condition of palms and soles. Patient 2 presents very subtle clinical findings, making difficult the diagnosis. And the other 3 patients have a typical presentation. Transient reactive aquagenic pseudokeratoderma has heterogeneous clinical features; in some cases, histopathologic findings, although subtle, help to confirm the diagnosis...
October 3, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29018145/acute-pancreatitis-with-eruptive-xanthoma
#10
Serkan Duzayak, Zeynel Abidin Sayiner, Suna Erkılıç, Huseyin Serhat Inaloz
Eruptive xanthomas are benign skin lesions caused by localised deposition of lipids in the dermis. Xanthomas can present as early manifestations of systemic disorders, which are typically caused by elevated levels of serum triglycerides and uncontrolled diabetes. Early recognition and treatment of the underlying condition decreases morbidity and mortality. After treatment of the underlying metabolic disorders, lesions mostly disappear without leaving scars. We present a case with multiple yellowish, erythematous papules on the extremities suggestive of eruptive xanthomas admitted to our hospital with acute pancreatitis...
October 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29016541/a-novel-treatment-of-acne-keloidalis-nuchae-by-long-pulsed-alexandrite-laser
#11
Abeer Tawfik, Mai Abdelraouf Osman, Iman Rashwan
BACKGROUND: Acne keloidalis nuchae (AKN) is a dermatological condition characterized by follicular-based papules and pustules that later form hypertrophic or keloid-like scars. Laser-assisted hair reduction such as 810-nm diode laser and 1,064-nm Nd:YAG laser have been used for treating AKN with promising results. OBJECTIVE: To evaluate the therapeutic effect and safety of alexandrite laser in the treatment of different lesions of AKN. METHODS: Seventeen male patients with AKN received 6 sessions of 755-nm alexandrite laser...
October 6, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29016328/intralesional-infiltration-with-meglumine-antimoniate-for-the-treatment-of-leishmaniasis-recidiva-cutis-in-ecuador
#12
Manuel Calvopiña, William Cevallos, Yolanda Paredes, Edison Puebla, Jessica Flores, Richard Loor, José Padilla
Meglumine Antimoniate (MA), administered intramuscularly for 21 continuous days is the recommended treatment of leishmaniases in Ecuador. However, because of its toxicity and requirement for intramuscular injections, treatment is frequently abandoned before completion. In addition, therapeutic failure and reactivation are not uncommon. Here we evaluate the efficacy and safety of MA administered intralesionally (IL) in leishmaniasis recidiva cutis (LRC). LRC is a special clinical variant of cutaneous leishmaniasis, characterized by reactivation at the edges of a primary cured lesion, presenting with active papules around the scar...
September 5, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29016295/ignoring-the-itch-the-global-health-problem-of-scabies
#13
Lola V Stamm, Lindsay C Strowd
Infestation with Sarcoptes scabiei var. hominis is a common human parasitic affliction endemic in tropical developing countries. Scabies is transmitted by close person-person contact, and outbreaks have been reported in reception centers for asylum seekers. Scabies presents clinically as extremely pruritic excoriated papules and linear burrows in the skin. This infestation predisposes to bacterial skin infections that can result in serious complications affecting the kidneys and possibly the heart. Treatment of individuals with scabies and their close contacts involves the use of antiparasitic agents...
October 2, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28983955/associations-between-anti-melanoma-differentiation-associated-gene-5-antibody-and-demographics-clinical-characteristics-and-laboratory-results-of-patients-with-dermatomyositis-a-systematic-meta-analysis
#14
Ju Li, Yan Liu, Yongsheng Li, Fang Li, Kai Wang, Wenyou Pan, Deqian Meng
Anti-melanoma differentiation-associated gene 5 (MDA5) antibody is a specific biomarker in patients with dermatomyositis (DM). Results from several studies that examined the relationship between anti-MDA5 antibody and the demographics, clinical characteristics and laboratory results of DM patients have been conflicting. The purpose of this study was to identify the relationship, if any, of anti-MDA5 antibody with demographics, clinical characteristics and laboratory results of DM patients. PubMed, Web of Science, Embase and the Cochrane Library databases were searched for studies without language restrictions conducted before 16 March 2017...
October 6, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28979883/skindia-quiz-41-asymptomatic-skin-colored-papule-on-the-scalp-skin
#15
Isa An, Ibrahim Ibiloglu, Omer Akburak, Sedat Akdeniz
No abstract text is available yet for this article.
September 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28978321/a-case-of-pseudoxanthoma-elasticum-with-proliferative-diabetic-retinopathy
#16
Keigo Kakurai, Maiko Hayashi, Kanako Yamada, Norihiko Ishizaki, Yumiko Yonemoto, Seita Morishita, Ryohsuke Kohmoto, Takaki Sato, Teruyo Kida, Tsunehiko Ikeda
BACKGROUND: To report the case of a patient with pseudoxanthoma elasticum (PXE) and proliferative diabetic retinopathy (PDR), and discuss the relationship between PXE and diabetic retinopathy (DR). CASE PRESENTATION: A 47-year-old man with PXE presented with angioid streaks and DR in both eyes, and bilateral panretinal photocoagulation was performed for treatment. Vitrectomy had previously been performed in his right eye for vitreous hemorrhage due to PDR. Systemic findings included multiple, discrete, symmetrical, small yellow papules bilaterally in the axilla and inguinal region...
October 4, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28976126/unilateral-angiokeratoma-of-vulva-a-rare-clinic-entity
#17
Aytekin Tokmak, Demet Kokanalı, Nagihan Özcan Cengaver, Gülçin Yıldırım, Ali I Rfan Güzel, Nafiye Yılmaz
The aim of this study is to present a very rare dermatologic condition of the vulva. Angiokeratoma is a benign dilation of ectatic thin-walled blood vessels and congested capillaries in the superficial dermal layer of skin. It occurs predominantly in men and extremely rare in women. Angiokeratoma presents as single or multiple papular lesions on the vulva with smooth or verrucous surface. These lesions are easily confused with infectious disease, inflammatory lesions, and epithelial tumors. In this report, we presented a 42 year old unmarried woman who was admitted to our clinic with complaints of two papuler lesions of the right labium majus with vaginal discharge, vulvar pruritis, and vulvar edema...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28971780/herpes-labialis-an-update
#18
Alexander K C Leung, Benjamin Barankin
BACKGROUND: Herpes labialis is characterized by recurrent vesicular eruptions primarily on the lips and perioral skin. The condition is contagious, can cause significant discomfort/pain, and can have an adverse effect on quality of life. OBJECTIVE: To update the evaluation and treatment of herpes labialis. METHODS: A PubMed search was completed in Clinical Queries using the key term "herpes labialis". Patents were searched using the key term "herpes labialis" from www...
October 3, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28971181/coexistence-of-eruptive-syringoma-and-bilateral-nipple-vitiligo-could-there-be-a-common-immunopathogenesis
#19
Sirin Yasar, Nurhan Doner, Pembegul Gunes
The rarely seen eruptive syringoma (ES) is characterized by small, skin-colored, papules. Lesions are benign; however, treatment is often unsuccessful. Recent studies have a suggested role of the autoimmune response, rather than reactive proliferation of acrosyringium in the pathogenesis of ES. There are reports in the literature of an association between syringoma and diabetes mellitus as well as alopecia areata, which support a theory of an autoimmune role; however, there has been no report of coexistence of ES and vitiligo thus far...
2017: Northern Clinics of Istanbul
https://www.readbyqxmd.com/read/28963879/accuracy-of-serum-ige-concentrations-and-papule-diameter-in-the-diagnosis-of-cow-s-milk-allergy
#20
Jackeline M Franco, Ana Paula S G Pinheiro, Sarah C F Vieira, Íkaro Daniel C Barreto, Ricardo Q Gurgel, Renata R Cocco, Dirceu Solé
OBJECTIVE: To compare serum concentrations of specific IgE and mean papule diameters induced in the immediate skin reactivity test with cow's milk (CM) and its fractions with results of the oral challenge test (OCT), and to establish cutoff points capable of predicting clinical reactivity to CM in patients treated at a referral service. METHODS: One hundred and twenty-two children (median of 17 months) with a history of immediate reactions to CM and presence of specific IgE for CM and/or its fractions (positive skin and/or IgE serum tests) were submitted to open OCT with CM...
September 27, 2017: Jornal de Pediatria
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