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https://www.readbyqxmd.com/read/28030492/stapled-versus-handsewn-a-prospective-emergency-surgery-study-shapes-an-american-association-for-the-surgery-of-trauma-multi-institutional-study
#1
Brandon R Bruns, David S Morris, Martin Zielinski, Nathan T Mowery, Preston R Miller, Kristen Arnold, Herb A Phelan, Jason Murry, David Turay, John Fam, John S Oh, Oliver L Gunter, Toby Enniss, Joseph D Love, David Skarupa, Matthew Benns, Alisan Fathalizadeh, Pak Shan Leung, Matthew M Carrick, Brent Jewett, Joseph Sakran, Lindsay O'Meara, Anthony V Herrera, Hegang Chen, Thomas M Scalea, Jose J Diaz
BACKGROUND: Data from the trauma patient population suggests handsewn anastomoses (HS) are superior to stapled (ST). A recent retrospective study in emergency general surgery (EGS) patients had similar findings. The aim of the current study is to evaluate HS and ST anastomoses in EGS patients undergoing urgent/emergent operations. METHODS: The study was sponsored by the AAST Multi-Institutional Studies Committee. Patients undergoing urgent/emergent bowel resection for EGS pathology were prospectively enrolled from 7/22/2013-12/31/2015...
December 23, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27970407/tct-232-the-glasgow-mri-rotational-atherectomy-study-glamoros-hsra-pci-is-associated-with-a-low-rate-of-peri-procedural-mi-and-a-significant-improvement-in-ischemic-burden
#2
David Corcoran, Colin Berry, Guillaume Clerfond, David Carrick, Kenneth Mangion, Barry Hennigan, John Paul Rocchiccioli, Aleksandra Radjenovic, Mitchell Lindsay, Hany Eteiba, Keith Oldroyd, Margaret McEntegart
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969895/tct-528-glasgow-mri-rotational-atherectomy-study-physiology-reflects-procedural-success-the-glamoros-study
#3
Barry Hennigan, Colin Berry, David Corcoran, David Carrick, Mitchell Lindsay, Hany Eteiba, Stuart Watkins, Keith Oldroyd, Margaret McEntegart
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27959674/tinea-imbricata
#4
Carrick Burns, Johannah Valentine
An 18-year-old Fijian woman presented with a 3-year history of a concentric, scaly rash on her shoulders; the rash was also present on her trunk, arms, and legs (not shown). The rash was pruritic and progressively spread to involve approximately 70% of the body-surface area. Her brother had similar..
December 8, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27956200/anatomic-relationships-of-the-pelvic-autonomic-nervous-system-in-female-cadavers-clinical-applications-to-pelvic%C3%A2-surgery
#5
Christopher M Ripperda, Lindsey A Jackson, John N Phelan, Kelley S Carrick, Marlene M Corton
BACKGROUND: The integrity of the pelvic autonomic nervous system is essential for proper bowel, bladder, and sexual function. OBJECTIVE: The purpose of this study was to characterize the anatomic path of the pelvic autonomic system and to examine relationships to clinically useful landmarks. STUDY DESIGN: Detailed dissections were performed in 17 female cadavers. Relationships of the superior hypogastric plexus to aortic bifurcation and midpoint of sacral promontory were examined; the length and width of plexus was documented...
December 9, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27941903/a-novel-method-for-estimating-myocardial-strain-assessment-of-deformation-tracking-against-reference-magnetic-resonance-methods-in-healthy-volunteers
#6
Kenneth Mangion, Hao Gao, Christie McComb, David Carrick, Guillaume Clerfond, Xiaodong Zhong, Xiaoyu Luo, Caroline E Haig, Colin Berry
We developed a novel method for tracking myocardial deformation using cardiac magnetic resonance (CMR) cine imaging. We hypothesised that circumferential strain using deformation-tracking has comparable diagnostic performance to a validated method (Displacement Encoding with Stimulated Echoes- DENSE) and potentially diagnostically superior to an established cine-strain method (feature-tracking). 81 healthy adults (44.6 ± 17.7 years old, 47% male), without any history of cardiovascular disease, underwent CMR at 1...
December 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27940095/the-epidemiology-prognosis-and-trends-of-severe-traumatic-brain-injury-with-presenting-glasgow-coma-scale-of-3
#7
Kristin Salottolo, Matthew Carrick, A Stewart Levy, Brent C Morgan, Denetta S Slone, David Bar-Or
PURPOSE: To characterize trends and prognosis of severe traumatic brain injury (TBI). METHODS: This 5-year multicenter retrospective study included patients with TBI and Glasgow Coma Scale of 3. We analyzed demographic and clinical characteristics and mortality using Pearson χ(2) tests, Cochran-Armitage trend tests, and stepwise logistic regression. Analyses were stratified by vehicular and fall etiologies; other etiologies were excluded (24%). RESULTS: Included were 481 patients...
December 2, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27923912/erratum-for-the-research-article-a-computationally-identified-compound-antagonizes-excess-fgf-23-signaling-in-renal-tubules-and-a-mouse-model-of-hypophosphatemia-by-z-xiao-d-riccardi-h-a-velazquez-a-l-chin-c-r-yates-j-d-carrick-j-c-smith-j-baudry-l-d-quarles
#8
https://www.readbyqxmd.com/read/27914661/statin-discontinuation-and-mortality-in-an-older-adult-population-with-traumatic-brain-injury-a-four-year-multi-centre-observational-cohort-study
#9
Alessandro Orlando, Christine Thomas, Matthew Carrick, D Sue Slone, Charles W Mains, David Bar-Or
INTRODUCTION: Statin discontinuation has been investigated in a wide range of diseases and injuries, but there is a paucity of data in the older adult population with traumatic brain injury (TBI). The purpose of this study was to re-examine the extent to which early discontinuation of pre-injury statin (PIS) therapy increases the risk of poor patient outcomes in older adult patients suffering a TBI. METHODS: This was a retrospective observational cohort study of adult trauma patients with a blunt TBI across three trauma centres over four years...
November 25, 2016: Injury
https://www.readbyqxmd.com/read/27903541/lifelong-physical-activity-regardless-of-dose-is-not-associated-with-myocardial-fibrosis
#10
Shuaib M Abdullah, Kyler W Barkley, Paul S Bhella, Jeffrey L Hastings, Susan Matulevicius, Naoki Fujimoto, Shigeki Shibata, Graeme Carrick-Ranson, M Dean Palmer, Nainesh Gandhi, Laura F DeFina, Benjamin D Levine
BACKGROUND: Recent reports have suggested that long-term, intensive physical training may be associated with adverse cardiovascular effects, including the development of myocardial fibrosis. However, the dose-response association of different levels of lifelong physical activity on myocardial fibrosis has not been evaluated. METHODS AND RESULTS: Seniors free of major chronic illnesses were recruited from predefined populations based on the consistent documentation of stable physical activity over >25 years and were classified into 4 groups by the number of sessions/week of aerobic activities ≥30 minutes: sedentary (group 1), <2 sessions; casual (group 2), 2 to 3 sessions; committed (group 3), 4 to 5 sessions; and Masters athletes (group 4), 6 to 7 sessions plus regular competitions...
November 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27881767/daylight-saving-time-can-decrease-the-frequency-of-wildlife-vehicle-collisions
#11
William A Ellis, Sean I FitzGibbon, Benjamin J Barth, Amanda C Niehaus, Gwendolyn K David, Brendan D Taylor, Helena Matsushige, Alistair Melzer, Fred B Bercovitch, Frank Carrick, Darryl N Jones, Cathryn Dexter, Amber Gillett, Martin Predavec, Dan Lunney, Robbie S Wilson
Daylight saving time (DST) could reduce collisions with wildlife by changing the timing of commuter traffic relative to the behaviour of nocturnal animals. To test this idea, we tracked wild koalas (Phascolarctos cinereus) in southeast Queensland, where koalas have declined by 80% in the last 20 years, and compared their movements with traffic patterns along roads where they are often killed. Using a simple model, we found that DST could decrease collisions with koalas by 8% on weekdays and 11% at weekends, simply by shifting the timing of traffic relative to darkness...
November 2016: Biology Letters
https://www.readbyqxmd.com/read/27879395/a-computationally-identified-compound-antagonizes-excess-fgf-23-signaling-in-renal-tubules-and-a-mouse-model-of-hypophosphatemia
#12
Zhousheng Xiao, Demian Riccardi, Hector A Velazquez, Ai L Chin, Charles R Yates, Jesse D Carrick, Jeremy C Smith, Jerome Baudry, L Darryl Quarles
Fibroblast growth factor-23 (FGF-23) interacts with a binary receptor complex composed of α-Klotho (α-KL) and FGF receptors (FGFRs) to regulate phosphate and vitamin D metabolism in the kidney. Excess FGF-23 production, which causes hypophosphatemia, is genetically inherited or occurs with chronic kidney disease. Among other symptoms, hypophosphatemia causes vitamin D deficiency and the bone-softening disorder rickets. Current therapeutics that target the receptor complex have limited utility clinically. Using a computationally driven, structure-based, ensemble docking and virtual high-throughput screening approach, we identified four novel compounds predicted to selectively inhibit FGF-23-induced activation of the FGFR/α-KL complex...
November 22, 2016: Science Signaling
https://www.readbyqxmd.com/read/27826551/noncoding-rna-regulation-of-dopamine-signaling-in-diseases-of-the-central-nervous-system
#13
REVIEW
William T Carrick, Brandi Burks, Murray J Cairns, Jannet Kocerha
Dopaminergic neurotransmission mediates a majority of the vital central nervous system functions. Disruption of these synaptic events provokes a multitude of neurological pathologies, including Parkinson's, schizophrenia, depression, and addiction. Growing evidence supports a key role for noncoding RNA (ncRNA) regulation in the synapse. This review will discuss the role of both short and long ncRNAs in dopamine signaling, including bioinformatic examination of the pathways they target. Specifically, we focus on the contribution of ncRNAs to dopaminergic dysfunction in neurodegenerative as well as psychiatric disease...
2016: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/27809761/leveraging-genetically-simple-traits-to-identify-small-effect-variants-for-complex-phenotypes
#14
K E Kemper, M D Littlejohn, T Lopdell, B J Hayes, L E Bennett, R P Williams, X Q Xu, P M Visscher, M J Carrick, M E Goddard
BACKGROUND: Polymorphisms underlying complex traits often explain a small part (less than 1 %) of the phenotypic variance (σ(2)P). This makes identification of mutations underling complex traits difficult and usually only a subset of large-effect loci are identified. One approach to identify more loci is to increase sample size of experiments but here we propose an alternative. The aim of this paper is to use secondary phenotypes for genetically simple traits during the QTL discovery phase for complex traits...
November 3, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27803036/comparative-prognostic-utility-of-indexes-of-microvascular-function-alone-or-in-combination-in-patients-with-an-acute-st-segment-elevation-myocardial-infarction
#15
David Carrick, Caroline Haig, Nadeem Ahmed, Jaclyn Carberry, Vannesa Teng Yue May, Margaret McEntegart, Mark C Petrie, Hany Eteiba, Mitchell Lindsay, Stuart Hood, Stuart Watkins, Andrew Davie, Ahmed Mahrous, Ify Mordi, Ian Ford, Aleksandra Radjenovic, Keith G Oldroyd, Colin Berry
BACKGROUND: Primary percutaneous coronary intervention is frequently successful at restoring coronary artery blood flow in patients with acute ST-segment-elevation myocardial infarction; however, failed myocardial reperfusion commonly passes undetected in up to half of these patients. The index of microvascular resistance (IMR) is a novel invasive measure of coronary microvascular function. We aimed to investigate the pathological and prognostic significance of an IMR>40, alone or in combination with a coronary flow reserve (CFR≤2...
December 6, 2016: Circulation
https://www.readbyqxmd.com/read/27791437/urinary-biomarkers-for-renal-tract-malformations
#16
Pedro Magalhães, Joost P Schanstra, Emma Carrick, Harald Mischak, Petra Zürbig
Renal tract malformations (RTMs) are congenital anomalies of the kidneys and urinary tract, which are the major cause of end-stage renal disease in children. Using immunoassay-based approaches (ELISA, western blot), individual urinary proteins including transforming growth factor β, tumor necrosis factor and monocyte attractant proteins 1 were found to be associated to RTMs. However, only mass spectrometry (MS) based methods leading to the identification of panels of protein-based markers composed of fragments of the extracellular matrix allowed the prediction of progression of RTMs and its complications...
November 15, 2016: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27699259/microvascular-resistance-of-the-culprit-coronary-artery-in-acute-st-elevation-myocardial-infarction
#17
David Carrick, Caroline Haig, Jaclyn Carberry, Vannesa Teng Yue May, Peter McCartney, Paul Welsh, Nadeem Ahmed, Margaret McEntegart, Mark C Petrie, Hany Eteiba, Mitchell Lindsay, Stuart Hood, Stuart Watkins, Ahmed Mahrous, Samuli M O Rauhalammi, Ify Mordi, Ian Ford, Aleksandra Radjenovic, Naveed Sattar, Keith G Oldroyd, Colin Berry
BACKGROUND: Failed myocardial reperfusion is common and prognostically important after acute ST-elevation myocardial infarction (STEMI). The purpose of this study was to investigate coronary flow reserve (CFR), a measure of vasodilator capacity, and the index of microvascular resistance (IMR; mmHg × s) in the culprit artery of STEMI survivors. METHODS: IMR (n = 288) and CFR (n = 283; mean age [SD], 60 [12] years) were measured acutely using guide wire-based thermodilution...
May 5, 2016: JCI Insight
https://www.readbyqxmd.com/read/27642494/oxidation-reduction-potential-as-a-biomarker-for-severity-and-acute-outcome-in-traumatic-brain-injury
#18
Kimberly B Bjugstad, Leonard T Rael, Stewart Levy, Matthew Carrick, Charles W Mains, Denetta S Slone, David Bar-Or
There are few reliable markers for assessing traumatic brain injury (TBI). Elevated levels of oxidative stress have been observed in TBI patients. We hypothesized that oxidation-reduction potential (ORP) could be a potent biomarker in TBI. Two types of ORP were measured in patient plasma samples: the static state of oxidative stress (sORP) and capacity for induced oxidative stress (icORP). Differences in ORP values as a function of time after injury, severity, and hospital discharge were compared using ANOVAs with significance at p ≤ 0...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27635065/the-prostate-lung-colorectal-and-ovarian-cancer-plco-screening-trial-pathology-tissue-resource
#19
Claire S Zhu, Wen-Yi Huang, Paul F Pinsky, Christine D Berg, Mark Sherman, Kelly J Yu, Danielle M Carrick, Amanda Black, Robert Hoover, Petra Lenz, Craig Williams, Laura Hawkins, Matthew Chaloux, Susan Yurgalevitch, Sunitha Mathew, Amy Miller, Vanessa Olivo, Asia Khan, Shannon M Pretzel, Deborah Multerer, Patricia Beckmann, Karen G Broski, Neal D Freedman
BACKGROUND: Pathology tissue specimens with associated epidemiologic and clinical data are valuable for cancer research. The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial undertook a large-scale effort to create a public resource of pathology tissues from PLCO participants who developed a cancer during the trial. METHODS: Formalin-fixed paraffin-embedded tissue blocks were obtained from pathology laboratories on a loan basis for central processing of tissue microarrays, with additional free-standing tissue cores collected for nucleic acid extraction...
December 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27607872/distance-from-cervicovaginal-junction-to-anterior-peritoneal-reflection-measured-during-vaginal-hysterectomy
#20
Sunil Balgobin, Cherine A Hamid, Kelley S Carrick, T Ignacio Montoya, Joseph I Schaffer, Marlene M Corton
OBJECTIVE: To quantify the distance of the dissection plane from the cervicovaginal junction to the anterior peritoneal reflection for vaginal hysterectomy. METHODS: This is a descriptive study examining the dissection plane for anterior colpotomy in 22 surgical patients undergoing vaginal hysterectomy and in nine cadaver specimens. Intraoperatively, the distance from the vaginal incision to the anterior peritoneal reflection was measured on the uterus after removal...
October 2016: Obstetrics and Gynecology
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