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https://www.readbyqxmd.com/read/28643430/platinum-containing-regimens-for-metastatic-breast-cancer
#1
REVIEW
Sam J Egger, Melina L Willson, Jenna Morgan, Harriet S Walker, Sue Carrick, Davina Ghersi, Nicholas Wilcken
BACKGROUND: Studies have reported high tumour response rates for platinum-containing regimens in the treatment of women with metastatic breast cancer. Most of these studies were conducted prior to the 'intrinsic subtype' era, and did not specifically focus on metastatic triple-negative breast cancers (mTNBCs). OBJECTIVES: To identify and review the evidence from randomised trials comparing platinum-containing chemotherapy regimens with regimens not containing platinum in the management of women with metastatic breast cancer...
June 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28593195/lake-bacterial-assemblage-composition-is-sensitive-to-biological-disturbance-caused-by-an-invasive-filter-feeder
#2
Vincent J Denef, Hunter J Carrick, Joann Cavaletto, Edna Chiang, Thomas H Johengen, Henry A Vanderploeg
One approach to improve forecasts of how global change will affect ecosystem processes is to better understand how anthropogenic disturbances alter bacterial assemblages that drive biogeochemical cycles. Species invasions are important contributors to global change, but their impacts on bacterial community ecology are rarely investigated. Here, we studied direct impacts of invasive dreissenid mussels (IDMs), one of many invasive filter feeders, on freshwater lake bacterioplankton. We demonstrated that direct effects of IDMs reduced bacterial abundance and altered assemblage composition by preferentially removing larger and particle-associated bacteria...
May 2017: MSphere
https://www.readbyqxmd.com/read/28582672/work-zone-sign-design-for-increased-driver-compliance-and-worker-safety
#3
Md Mahmudur Rahman, Lesley Strawderman, Teena Garrison, Deborah Eakin, Carrick C Williams
Many studies have investigated the effect of dynamic message signs (DMS) on drivers' speed reduction and compliance in work zones, yet only a few studies have examined the design of sign content of DMS. The purpose of this study was to develop design standards for DMS to improve driver compliance and worker safety. This study investigated the impact of sign content, frame refresh rate, and sign placement on driver speed reduction, compliance, and eye movements. A total of 44 participants were recruited for this study...
June 2, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28558603/social-media-awareness-and-implications-in-nursing-leadership
#4
Candace W Burton, Monica R McLemore, Laura Perry, Jenny Carrick, Mona Shattell
Many nursing professionals-may be reluctant to engage in or are confused about appropriate use of social media in a clinical, research, or policy context. To address this issue, we developed a study to enhance nurse leaders' facility with social media in the context of a national professional meeting. This study examined a social media campaign at the 2015 American Academy of Nursing conference. The campaign was intended to bridge the gap between active social media users and nonusers attending the conference...
November 2016: Policy, Politics & Nursing Practice
https://www.readbyqxmd.com/read/28541728/methamphetamine-and-psychiatry-a-story-of-the-colourless-substance-of-abuse
#5
Shuichi Suetani, Jill Reddan, Carrick Anderson
OBJECTIVE: The current paper aims to provide an overview of methamphetamine in its historical context, integrated with a current understanding derived from animal studies and clinical experience. CONCLUSION: Despite over a century of clinical experience, methamphetamine remains a troublesome substance. There remains an urgent need at multiple levels from various sectors to combat this ongoing problem, and psychiatry has an essential role in this endeavour.
June 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28538638/perioperative-use-of-nonsteroidal-anti-inflammatory-drugs-and-the-risk-of-anastomotic-failure-in-emergency-general-surgery
#6
Nadeem N Haddad, Brandon R Bruns, Toby M Enniss, David Turay, Joseph V Sakran, Alisan Fathalizadeh, Kristen Arnold, Jason S Murry, Matthew M Carrick, Matthew Hernandez, Margaret H Lauerman, Martin D Zielinski
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used analgesic and anti-inflammatory adjuncts. NSAID administration may potentially increase the risk of postoperative gastrointestinal anastomotic failure (AF). We aim to determine if perioperative NSAID utilization influences gastrointestinal anastomotic failure in emergency general surgery (EGS) patients undergoing gastrointestinal resection and anastomosis. METHODS: Post hoc analysis of a multi-institutional prospectively collected database was performed...
May 22, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28522657/near-drowning-in-a-48-year-old-man
#7
Kirsty McDowell, David Carrick, Robin Weir
No abstract text is available yet for this article.
May 18, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28490566/a-retrospective-cohort-study-of-the-utility-of-the-modified-early-warning-score-for-interfacility-transfer-of-patients-with-traumatic-injury
#8
Kristin Salottolo, Matthew Carrick, Jacob Johnson, Mark Gamber, David Bar-Or
OBJECTIVE: The modified early warning score (MEWS) is a 'track and trigger' score using routine physiological vital signs. The objective is to determine if the pretransfer MEWS can be used for predicting outcomes in trauma patients requiring interfacility transfer to higher levels of care. DESIGN, SETTING AND PARTICIPANTS: Retrospective study of consecutively transferred trauma patients into a level-II trauma centre from 2013 to 2014. INTERVENTIONS: None...
May 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28452877/incompatible-type-a-plasma-transfusion-in-patients-requiring-massive-transfusion-protocol-outcomes-of-an-eastern-association-for-the-surgery-of-trauma-multicenter-study
#9
W Tait Stevens, Bryan C Morse, Andrew Bernard, Daniel L Davenport, Valerie G Sams, Michael D Goodman, Russell Dumire, Matthew M Carrick, Patrick McCarthy, James R Stubbs, Timothy A Pritts, Christopher J Dente, Xian Luo-Owen, Jason A Gregory, David Turay, Dina Gomaa, Juan C Quispe, Caitlin A Fitzgerald, Nadeem N Haddad, Asad Choudhry, Jose F Quesada, Martin D Zielinski
With a relative shortage of type AB plasma, many centers have converted to type A plasma for resuscitation of patients whose blood type is unknown. The goal of this study is to determine outcomes for trauma patients who received incompatible plasma transfusions as part of a massive transfusion protocol (MTP). METHODS: As part of an Eastern Association for the Surgery of Trauma multi-institutional trial, registry and blood bank data were collected from eight trauma centers for trauma patients (age, ≥ 15 years) receiving emergency release plasma transfusions as part of MTPs from January 2012 to August 2016...
July 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28431413/novel-oral-anticoagulants-and-trauma-the-results-of-a-prospective-american-association-for-the-surgery-of-trauma-multi-institutional-trial
#10
Leslie Kobayashi, Galinos Barmparas, Patrick Bosarge, Carlos V Brown, Marko Bukur, Matthew M Carrick, Richard D Catalano, Jan Holly-Nicolas, Kenji Inaba, Stephen Kaminski, Amanda L Klein, Tammy Kopelman, Eric J Ley, Ericca M Martinez, Forrest O Moore, Jason Murry, Raminder Nirula, Douglas Paul, Jacob Quick, Omar Rivera, Martin Schreiber, Raul Coimbra
BACKGROUND: The number of anticoagulated trauma patients is increasing. Trauma patients on warfarin have been found to have poor outcomes, particularly after intracranial hemorrhage (ICH). However, the effect of novel oral anticoagulants (NOAs) on trauma outcomes is unknown. We hypothesized that patients on NOAs would have higher rates of ICH, ICH progression, and death compared with patients on traditional anticoagulant and antiplatelet agents. METHODS: This was a prospective observational trial across 16 trauma centers...
May 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28364045/diagnostic-accuracy-of-3-0-t-magnetic-resonance-t1-and-t2-mapping-and-t2-weighted-dark-blood-imaging-for-the-infarct-related-coronary-artery-in-non-st-segment-elevation-myocardial-infarction
#11
Jamie Layland, Samuli Rauhalammi, Matthew M Y Lee, Nadeem Ahmed, Jaclyn Carberry, Vannesa Teng Yue May, Stuart Watkins, Christie McComb, Kenneth Mangion, John D McClure, David Carrick, Anna O'Donnell, Arvind Sood, Margaret McEntegart, Keith G Oldroyd, Aleksandra Radjenovic, Colin Berry
BACKGROUND: Patients with recent non-ST-segment elevation myocardial infarction commonly have heterogeneous characteristics that may be challenging to assess clinically. METHODS AND RESULTS: We prospectively studied the diagnostic accuracy of 2 novel (T1, T2 mapping) and 1 established (T2-weighted short tau inversion recovery [T2W-STIR]) magnetic resonance imaging methods for imaging the ischemic area at risk and myocardial salvage in 73 patients with non-ST-segment elevation myocardial infarction (mean age 57±10 years, 78% male) at 3...
March 31, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28252992/the-case-of-the-missing-visual-details-occlusion-and-long-term-visual-memory
#12
Carrick C Williams, Kyle A Burkle
To investigate the critical information in long-term visual memory representations of objects, we used occlusion to emphasize 1 type of information or another. By occluding 1 solid side of the object (e.g., top 50%) or by occluding 50% of the object with stripes (like a picket fence), we emphasized visible information about the object, processing the visible details in the former and the object's overall form in the latter. On a token discrimination test, surprisingly, memory for solid or stripe occluded objects at either encoding (Experiment 1) or test (Experiment 2) was the same...
March 2, 2017: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/28251012/ectopic-thyroid-tissue-in-the-mediastinum-characterized-by-histology-and-functional-imaging-with-i-123-spect-ct
#13
Jed Hummel, Jason Wachsmann, Kelley Carrick, Orhan K Oz, Dana Mathews, Fangyu Peng
Ectopic thyroid tissue is a rare entity and when discovered it is typically along the pathway of embryologic migration of the thyroid. We present a case of incidental finding of ectopic thyroid tissue within mediastinum in a 61-year-old female patient with a history of total thyroidectomy for thyroiditis and nodules. The patient presented to emergency room with cough and right chest pain and underwent a chest computed tomographic angiogram (CTA) to exclude pulmonary embolism as part of chest pain workup. One right paratracheal mediastinal soft tissue nodule was visualized on the images of CTA...
2017: Case Reports in Radiology
https://www.readbyqxmd.com/read/28167013/intermediate-outcomes-of-a-transcutaneous-bone-conduction-hearing-device-in-a-paediatric-population
#14
Panagiotis A Dimitriadis, Suzanne Carrick, Jaydip Ray
OBJECTIVE: The aim of this study was to review the outcomes of Bone Anchored Hearing Aid (BAHA(®)) Attract implantation in a cohort of paediatric patients. METHODS: Prospective data collection and case review were undertaken in a paediatric tertiary referral centre. We have included patients under the age of 16 years with unilateral or bilateral hearing loss that met the criteria for BAHA(®) Attract implantation. The main outcome measures were surgical complications and Patient Reported Outcomes including the 'Speech, Spatial and Qualities of Hearing scale' (SSQ-12) and 'Qualitative Feedback for BAHA(®) 5 Hearing Aids'...
March 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28135632/elevated-c-reactive-protein-and-posttraumatic-stress-pathology-among-survivors-of-the-9-11-world-trade-center-attacks
#15
Rebecca L Rosen, Nomi Levy-Carrick, Joan Reibman, Ning Xu, Yongzhao Shao, Mengling Liu, Lucia Ferri, Angeliki Kazeros, Caralee E Caplan-Shaw, Deepak R Pradhan, Michael Marmor, Isaac R Galatzer-Levy
BACKGROUND: Systemic inflammation has emerged as a promising marker and potential mechanism underlying post-traumatic stress disorder (PTSD). The relationship between posttraumatic stress pathology and systemic inflammation has not, however, been consistently replicated and is potentially confounded by comorbid illness or injury, common complications of trauma exposure. METHODS: We analyzed a large naturalistic cohort sharing a discrete physical and mental health trauma from the destruction of the World Trade Center (WTC) towers on September 11, 2001 (n = 641)...
January 16, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28030492/stapled-versus-hand-sewn-a-prospective-emergency-surgery-study-an-american-association-for-the-surgery-of-trauma-multi-institutional-study
#16
Brandon Robert Bruns, David S Morris, Martin Zielinski, Nathan T Mowery, Preston R Miller, Kristen Arnold, Herb A Phelan, Jason Murry, David Turay, John Fam, John S Oh, Oliver L Gunter, Toby Enniss, Joseph D Love, David Skarupa, Matthew Benns, Alisan Fathalizadeh, Pak Shan Leung, Matthew M Carrick, Brent Jewett, Joseph Sakran, Lindsay O'Meara, Anthony V Herrera, Hegang Chen, Thomas M Scalea, Jose J Diaz
BACKGROUND: Data from the trauma patient population suggests handsewn (HS) anastomoses are superior to stapled (ST). A recent retrospective study in emergency general surgery (EGS) patients had similar findings. The aim of the current study was to evaluate HS and ST anastomoses in EGS patients undergoing urgent/emergent operations. METHODS: The study was sponsored by the American Association for the Surgery of Trauma Multi-Institutional Studies Committee. Patients undergoing urgent/emergent bowel resection for EGS pathology were prospectively enrolled from July 22, 2013 to December 31, 2015...
March 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27970407/tct-232-the-glasgow-mri-rotational-atherectomy-study-glamoros-hsra-pci-is-associated-with-a-low-rate-of-peri-procedural-mi-and-a-significant-improvement-in-ischemic-burden
#17
David Corcoran, Colin Berry, Guillaume Clerfond, David Carrick, Kenneth Mangion, Barry Hennigan, John Paul Rocchiccioli, Aleksandra Radjenovic, Mitchell Lindsay, Hany Eteiba, Keith Oldroyd, Margaret McEntegart
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969895/tct-528-glasgow-mri-rotational-atherectomy-study-physiology-reflects-procedural-success-the-glamoros-study
#18
Barry Hennigan, Colin Berry, David Corcoran, David Carrick, Mitchell Lindsay, Hany Eteiba, Stuart Watkins, Keith Oldroyd, Margaret McEntegart
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27959674/tinea-imbricata
#19
Carrick Burns, Johannah Valentine
An 18-year-old Fijian woman presented with a 3-year history of a concentric, scaly rash on her shoulders; the rash was also present on her trunk, arms, and legs (not shown). The rash was pruritic and progressively spread to involve approximately 70% of the body-surface area. Her brother had similar..
December 8, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27956200/anatomic-relationships-of-the-pelvic-autonomic-nervous-system-in-female-cadavers-clinical-applications-to-pelvic%C3%A2-surgery
#20
Christopher M Ripperda, Lindsey A Jackson, John N Phelan, Kelley S Carrick, Marlene M Corton
BACKGROUND: The integrity of the pelvic autonomic nervous system is essential for proper bowel, bladder, and sexual function. OBJECTIVE: The purpose of this study was to characterize the anatomic path of the pelvic autonomic system and to examine relationships to clinically useful landmarks. STUDY DESIGN: Detailed dissections were performed in 17 female cadavers. Relationships of the superior hypogastric plexus to aortic bifurcation and midpoint of sacral promontory were examined; the length and width of plexus was documented...
April 2017: American Journal of Obstetrics and Gynecology
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