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https://www.readbyqxmd.com/read/29765033/an-epizootic-of-chlamydia-psittaci-equine-reproductive-loss-associated-with-suspected-spillover-from-native-australian-parrots
#1
Cheryl Jenkins, Martina Jelocnik, Melinda L Micallef, Francesca Galea, Alyce Taylor-Brown, Daniel R Bogema, Michael Liu, Brendon O'Rourke, Catherine Chicken, Joan Carrick, Adam Polkinghorne
Chlamydia psittaci is an avian pathogen capable of spill-over infections to humans. A parrot C. psittaci strain was recently detected in an equine reproductive loss case associated with a subsequent cluster of human C. psittaci infections. In this study, we screened for C. psittaci in cases of equine reproductive loss reported in regional New South Wales, Australia during the 2016 foaling season. C. psittaci specific-PCR screening of foetal and placental tissue samples from cases of equine abortion (n = 161) and foals with compromised health status (n = 38) revealed C...
May 16, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29741483/incidence-of-procedural-myocardial-infarction-and-cardiac-magnetic-resonance-imaging-detected-myocardial-injury-following-percutaneous-coronary-intervention-with-rotational-atherectomy
#2
Margaret McEntegart, David Corcoran, David Carrick, Guillaume Clerfond, Novalia Sidik, Damien Collison, Keith R Robertson, Aadil Shaukat, Stuart Watkins, Paul R Rocchicholi, Hany Eteiba, Mark P Petrie, Mitchell M Lindsay, Keith G Oldroyd, Colin Berry
No abstract text is available yet for this article.
May 8, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29662708/emergency-peripartum-hysterectomy-in-the-dubai-health-system-a-fifteen-year-experience
#3
Muna Abdulrazzaq Tahlak, Mahera Abdulrahman, Nawal Mahmood Hubaishi, Mushtaq Omar, Fatima Cherifi, Shazia Magray, Frederick Robert Carrick
Objective: To determine the incidence, demographic data, risk factors, indications, outcome and complications of emergency peripartum hysterectomy (EPH) performed in two major tertiary care hospitals in Dubai, and to compare the results with the literature. Materials and Methods: The records of all women who underwent EPH from January 2000 to December 2015 in two major tertiary care hospitals in Dubai were accessed and reviewed. Maternal characteristics, hysterectomy indications, outcomes, and postoperative complications were recorded using descriptive statistics to describe the cohort...
March 2018: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29611317/comparison-of-urine-and-plasma-peptidome-indicates-selectivity-in-renal-peptide-handling
#4
Pedro Magalhães, Claudia Pontillo, Martin Pejchinovski, Justyna Siwy, Magdalena Krochmal, Manousos Makridakis, Emma Carrick, Julie Klein, William Mullen, Joachim Jankowski, Antonia Vlahou, Harald Mischak, Joost P Schanstra, Petra Zürbig, Lars Pape
PURPOSE: Urine is considered to be produced predominantly as a result of plasma filtration in the kidney. However, the origin of the native peptides present in urine has never been investigated in detail. Therefore, we aimed to obtain a first insight into the origin of urinary peptides based on a side-by-side comprehensive analysis of the plasma and urine peptidome. METHODS: Twenty-two matched urine and plasma samples were analyzed for their peptidome using capillary electrophoresis coupled to mass spectrometry (CE-MS; for relative quantification) and CE- or LC coupled to tandem mass spectrometry (CE- or LC- MS/MS; for peptide identification)...
April 3, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29538791/using-recovery-oriented-principles-to-improve-consumer-empowerment-in-a-state-psychiatric-hospital
#5
Tom Bartholomew, Loren Gildar, Gwen Carrick, Angela Saafigueroa, Ruth Cook
The culture of state psychiatric hospitals may make it difficult to implement recovery-oriented principles such as empowerment. The current study describes efforts of one hospital to empower consumers of psychiatric hospital services using focus groups, surveys, and a workgroup to address the issue of low program attendance. The study determined the importance of identifying consumer goals, informing consumers about options for therapeutic group programming, and matching consumer goals to treatment. Identifying these items led to development of a consumer catalog designed to allow consumers of psychiatric hospital services to choose programs that aligned with their goals while also meeting staff needs to address problem areas on a treatment plan...
May 1, 2018: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/29538224/reshapes-increasing-aast-egs-grade-is-associated-with-anastomosis-type
#6
Matthew C Hernandez, Brandon R Bruns, Nadeem Haddad, Margaret Lauerman, David S Morris, Kristen Arnold, Herb A Phelan, David Turay, Jason Murry, John S Oh, Toby Enniss, Matthew M Carrick, Thomas M Scalea, Martin Zielinski
INTRODUCTION: Threatened, perforated, and infarcted bowel is managed with conventional resection and anastomosis (hand sewn (HS) or stapled (ST)). The SHAPES analysis demonstrated equivalence between HS and ST techniques, yet surgeons appeared to prefer (HS) for the critically ill. We hypothesized that HS is more frequent in patients with higher disease severity as measured by the AAST EGS grading system. METHODS: We performed a post hoc analysis of the SHAPES database...
March 12, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29522086/re-current-challenges-and-new-opportunities-for-gene-environment-interaction-studies-of-complex-diseases
#7
Danielle Mercatante Carrick, Anthony Dickherber, Rao L Divi
No abstract text is available yet for this article.
May 1, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29521777/heads-up-describing-and-implementing-a-time-saving-head-strike-protocol-at-a-level-ii-trauma-center
#8
Sharon Wacht, Kristin Salottolo, Amy Atnip, Michelle Hooks, Mary Bailie, Matthew Carrick
Head strikes can be fatal for patients taking blood thinners (anticoagulants or antiplatelets). Our trauma center instituted the "head strike protocol" to provide uniform and expedited care for adult trauma patients taking preinjury anticoagulants and antiplatelet medications with suspected head injury. The purpose of this article is to describe the development and implementation of the head strike protocol and compare time metrics and outcomes before and after implementing the protocol. Per the head strike protocol, patients with suspected traumatic intracranial hemorrhage (tICH) were screened for anticoagulants or antiplatelet medications by emergency medical service personnel/at first contact, activated as a Level II trauma and received a computed tomographic scan of the head within 30 min of arrival, and started reversal of blood products within 30 min of tICH confirmation...
March 2018: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/29350344/the-relationship-between-exercise-dose-and-health-related-quality-of-life-with-a-phase-iii-cardiac-rehabilitation-program
#9
Borja Del Pozo-Cruz, Graeme Carrick-Ranson, Stacey Reading, Paul Nolan, Lance C Dalleck
PURPOSE: To quantify the relationship between the change in exercise dose and health-related quality of life (HRQoL) in a cohort of patients participating in a community-based phase-3 cardiac rehabilitation (CR) program. METHODS: A retrospective, pre-experimental (no control group) design of 58 participants that completed a phase-3, 12-week exercise-based CR program was used to test the current hypothesis. Self-reported HRQoL (36-Item Short Form Health Survey Version 2, SF-36v2) was assessed prior and after completing the CR program...
April 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29341793/platelet-transfusion-does-not-improve-outcomes-in-patients-with-brain-injury-on-antiplatelet-therapy
#10
Jeremy L Holzmacher, Cassandra Reynolds, Mayur Patel, Patrick Maluso, Seth Holland, Nathaniel Gamsky, Henry Moore, Elizabeth Acquista, Matthew Carrick, Richard Amdur, Heather Hancock, Michael Metzler, Julie Dunn, Babak Sarani
INTRODUCTION: Platelet dysfunction following traumatic brain injury (TBI) is associated with worse outcomes. The efficacy of platelet transfusion to reverse antiplatelet medication (APM) remains unknown. Thrombelastography platelet mapping (TEG-PM) assesses platelet function. We hypothesize that platelet transfusion can reverse the effects of APM but does not improve outcomes following TBI. METHODS: An observational study at six US trauma centres was performed. Adult patients on APM with CT evident TBI after blunt injury were enrolled...
2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29298242/contemporary-management-of-high-grade-renal-trauma-results-from-the-american-association-for-the-surgery-of-trauma-genitourinary-trauma-study
#11
Sorena Keihani, Yizhe Xu, Angela P Presson, James M Hotaling, Raminder Nirula, Joshua Piotrowski, Christopher M Dodgion, Cullen M Black, Kaushik Mukherjee, Bradley J Morris, Sarah Majercik, Brian P Smith, Ian Schwartz, Sean P Elliott, Erik S DeSoucy, Scott Zakaluzny, Peter B Thomsen, Bradley A Erickson, Nima Baradaran, Benjamin N Breyer, Brandi Miller, Richard A Santucci, Matthew M Carrick, Timothy Hewitt, Frank N Burks, Jurek F Kocik, Reza Askari, Jeremy B Myers
BACKGROUND: The rarity of renal trauma limits its study and the strength of evidence-based guidelines. Although management of renal injuries has shifted toward a nonoperative approach, nephrectomy remains the most common intervention for high-grade renal trauma (HGRT). We aimed to describe the contemporary management of HGRT in the United States and also evaluate clinical factors associated with nephrectomy after HGRT. METHODS: From 2014 to 2017, data on HGRT (American Association for the Surgery of Trauma grades III-V) were collected from 14 participating Level-1 trauma centers...
March 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29251711/beta-blockers-in-critically-ill-patients-with-traumatic-brain-injury-results-from-a-multicenter-prospective-observational-american-association-for-the-surgery-of-trauma-study
#12
Eric J Ley, Samuel D Leonard, Galinos Barmparas, Navpreet K Dhillon, Kenji Inaba, Ali Salim, Karen R OʼBosky, Danielle Tatum, Hooman Azmi, Chad G Ball, Paul T Engels, Julie A Dunn, Matthew M Carrick, Jonathan P Meizoso, Sarah Lombardo, Bryan A Cotton, Thomas J Schroeppel, Sandro Rizoli, David S J Chang, Luis Alejandro de León, Joao Rezende-Neto, Tomas Jacome, Jimmy Xiao, Gina Mallory, Krishnamurti Rao, Lars Widdel, Samuel Godin, Angela Coates, Leo Andrew Benedict, Raminder Nirula, Sanjeev Kaul, Tong Li
BACKGROUND: Beta blockers, a class of medications that inhibit endogenous catecholamines interaction with beta adrenergic receptors, are often administered to patients hospitalized after traumatic brain injury (TBI). We tested the hypothesis that beta blocker use after TBI is associated with lower mortality, and secondarily compared propranolol to other beta blockers. METHODS: The American Association for the Surgery of Trauma Clinical Trial Group conducted a multi-institutional, prospective, observational trial in which adult TBI patients who required intensive care unit admission were compared based on beta blocker administration...
February 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29249435/the-effects-of-remote-ischaemic-preconditioning-on-coronary-artery-function-in-patients-with-stable-coronary-artery-disease
#13
D Corcoran, R Young, P Cialdella, P McCartney, A Bajrangee, B Hennigan, D Collison, D Carrick, A Shaukat, R Good, S Watkins, M McEntegart, J Watt, P Welsh, N Sattar, A McConnachie, K G Oldroyd, C Berry
BACKGROUND: Remote ischaemic preconditioning (RIPC) is a cardioprotective intervention invoking intermittent periods of ischaemia in a tissue or organ remote from the heart. The mechanisms of this effect are incompletely understood. We hypothesised that RIPC might enhance coronary vasodilatation by an endothelium-dependent mechanism. METHODS: We performed a prospective, randomised, sham-controlled, blinded clinical trial. Patients with stable coronary artery disease (CAD) undergoing elective invasive management were prospectively enrolled, and randomised to RIPC or sham (1:1) prior to angiography...
February 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29242240/persistence-of-infarct-zone-t2-hyperintensity-at-6-months-after-acute-st-segment-elevation-myocardial-infarction-incidence-pathophysiology-and-prognostic-implications
#14
Jaclyn Carberry, David Carrick, Caroline Haig, Nadeem Ahmed, Ify Mordi, Margaret McEntegart, Mark C Petrie, Hany Eteiba, Stuart Hood, Stuart Watkins, Mitchell Lindsay, Andrew Davie, Ahmed Mahrous, Ian Ford, Naveed Sattar, Paul Welsh, Aleksandra Radjenovic, Keith G Oldroyd, Colin Berry
BACKGROUND: The incidence and clinical significance of persistent T2 hyperintensity after acute ST-segment-elevation myocardial infarction (STEMI) is uncertain. METHODS AND RESULTS: Patients who sustained an acute STEMI were enrolled in a cohort study (BHF MR-MI: NCT02072850). Two hundred eighty-three STEMI patients (mean age, 59±12 years; 75% male) had cardiac magnetic resonance with T2 mapping performed at 2 days and 6 months post-STEMI. Persisting T2 hyperintensity was defined as infarct T2 >2 SDs from remote T2 at 6 months...
December 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29242043/sweep-tone-evoked-stimulus-frequency-otoacoustic-emissions-in-humans-development-of-a-noise-rejection-algorithm-and-normative-features
#15
Srikanta K Mishra, Carrick L Talmadge
In recent years, there has been a growing interest to measure stimulus frequency otoacoustic emissions (SFOAEs) using sweep tones. While there are several advantages of the sweep-tone technique, one of the major problems with sweep-tone methodologies is the lack of an objective analysis procedure that considers and rejects individual noisy recordings or noisy segments. A new efficient data-driven method for rejecting noisy segments in SFOAE analysis is proposed and the normative features of SFOAEs are characterized in fifty normal-hearing young adults...
November 20, 2017: Hearing Research
https://www.readbyqxmd.com/read/29240412/integration-of-on-column-chemical-reactions-in-protein-characterization-by-liquid-chromatography-mass-spectrometry-cross-path-reactive-chromatography
#16
Jake W Pawlowski, Ian Carrick, Igor A Kaltashov
Profiling of complex proteins by means of mass spectrometry (MS) frequently requires that certain chemical modifications of their covalent structure (e.g., reduction of disulfide bonds), be carried out prior to the MS or MS/MS analysis. Traditionally, these chemical reactions take place in the off-line mode to allow the excess reagents (the majority of which interfere with the MS measurements and degrade the analytical signal) to be removed from the protein solution prior to MS measurements. In addition to a significant increase in the analysis time, chemical reactions may result in a partial or full loss of the protein if the modifications adversely affect its stability, e...
January 16, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29153575/persistent-iron-within-the-infarct-core-after-st-segment-elevation-myocardial-infarction-implications-for-left-ventricular-remodeling-and-health-outcomes
#17
Jaclyn Carberry, David Carrick, Caroline Haig, Nadeem Ahmed, Ify Mordi, Margaret McEntegart, Mark C Petrie, Hany Eteiba, Stuart Hood, Stuart Watkins, Mitchell Lindsay, Andrew Davie, Ahmed Mahrous, Ian Ford, Naveed Sattar, Paul Welsh, Aleksandra Radjenovic, Keith G Oldroyd, Colin Berry
OBJECTIVES: This study sought to determine the incidence and prognostic significance of persistent iron in patients post-ST-segment elevation myocardial infarction (STEMI). BACKGROUND: The clinical significance of persistent iron within the infarct core after STEMI complicated by acute myocardial hemorrhage is poorly understood. METHODS: Patients who sustained an acute STEMI were enrolled in a cohort study (BHF MR-MI [Detection and Significance of Heart Injury in ST Elevation Myocardial Infarction])...
November 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29127706/peptide-strand-length-controls-the-energetics-of-self-assembly-and-morphology-of-%C3%AE-sheet-fibrils
#18
Robert P W Davies, Binbin Liu, Steven Maude, Lisa M Carrick, Irina Nyrkova, Tom C McLeish, Sarah A Harris
Self-assembling peptides can be used as versatile, natural, and multifunctional building blocks to produce a variety of well-defined nanostructures, materials and devices for applications in medicine and nanotechnology. Here, we concentrate on the 1D self-assembly of de novo designed Px-2 peptide β-strands into anti-parallel β-sheet tapes and higher order aggregates. We study six members of the Px-2 family, ranging from 3 amino acids (aa) to 13 aa in length, using a range of complementary experimental techniques, computer simulation and theoretical statistical mechanics...
November 11, 2017: Biopolymers
https://www.readbyqxmd.com/read/29077636/effects-of-sedentary-aging-and-lifelong-exercise-on-left-ventricular-systolic-function
#19
Erin J Howden, Graeme Carrick-Ranson, Satyam Sarma, Michinari Hieda, Naoki Fujimoto, Benjamin D Levine
PURPOSE: The current study examined whether age-related changes in left ventricular (LV) longitudinal systolic function is an adaptation to a more sedentary lifestyle and can be preserved by lifelong exercise training. METHODS: A cross-sectional examination of 18 sedentary young (37 ± 6 yr), 29 sedentary seniors (71 ± 5 yr, 0-3 exercise sessions per week), and 26 seniors (68 ± 5 yr) who had performed a committed level (four to seven exercise sessions per week) of lifelong (>25 yr) exercise...
March 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29051544/estimating-prognosis-in-patients-with-acute-myocardial-infarction-using-personalized-computational-heart-models
#20
Hao Gao, Kenneth Mangion, David Carrick, Dirk Husmeier, Xiaoyu Luo, Colin Berry
Biomechanical computational models have potential prognostic utility in patients after an acute ST-segment-elevation myocardial infarction (STEMI). In a proof-of-concept study, we defined two groups (1) an acute STEMI group (n = 6, 83% male, age 54 ± 12 years) complicated by left ventricular (LV) systolic dysfunction; (2) an age- and sex- matched hyper-control group (n = 6, 83% male, age 46 ± 14 years), no prior history of cardiovascular disease and normal systolic blood pressure (SBP < 130 mmHg)...
October 19, 2017: Scientific Reports
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