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https://www.readbyqxmd.com/read/29127706/peptide-strand-length-controls-the-energetics-of-self-assembly-and-morphology-of-%C3%AE-sheet-fibrils
#1
Robert P W Davies, Binbin Liu, Steven Maude, Lisa M Carrick, Irina Nyrkova, Tom C McLeish, Sarah A Harris
Self-assembling peptides can be used as versatile, natural, and multifunctional building blocks to produce a variety of well-defined nanostructures, materials and devices for applications in medicine and nanotechnology. Here, we concentrate on the 1D self-assembly of de novo designed Px-2 peptide β-strands into anti-parallel β-sheet tapes and higher order aggregates. We study six members of the Px-2 family, ranging from 3 amino acids (aa) to 13 aa in length, using a range of complementary experimental techniques, computer simulation and theoretical statistical mechanics...
November 11, 2017: Biopolymers
https://www.readbyqxmd.com/read/29077636/effects-of-sedentary-aging-and-lifelong-exercise-on-left-ventricular-systolic-function
#2
Erin J Howden, Graeme Carrick-Ranson, Satyam Sarma, Michinari Hieda, Naoki Fujimoto, Benjamin D Levine
PURPOSE: The current study examined whether age-related changes in left ventricular (LV) longitudinal systolic function is an adaptation to a more sedentary lifestyle and can be preserved by lifelong exercise training. METHODS: A cross-sectional examination of 18 sedentary young (37±6 years), 29 sedentary seniors (71±5 years, 0-3 exercise sessions/wk), and 26 seniors (68±5 years) who had performed a committed level (4-7 exercise sessions/wk) of lifelong (>25 years) exercise...
October 26, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29051544/estimating-prognosis-in-patients-with-acute-myocardial-infarction-using-personalized-computational-heart-models
#3
Hao Gao, Kenneth Mangion, David Carrick, Dirk Husmeier, Xiaoyu Luo, Colin Berry
Biomechanical computational models have potential prognostic utility in patients after an acute ST-segment-elevation myocardial infarction (STEMI). In a proof-of-concept study, we defined two groups (1) an acute STEMI group (n = 6, 83% male, age 54 ± 12 years) complicated by left ventricular (LV) systolic dysfunction; (2) an age- and sex- matched hyper-control group (n = 6, 83% male, age 46 ± 14 years), no prior history of cardiovascular disease and normal systolic blood pressure (SBP < 130 mmHg)...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29044245/biomarkers-of-chronic-inflammation-in-disease-development-and-prevention-challenges-and-opportunities
#4
Christina H Liu, Natalie D Abrams, Danielle M Carrick, Preethi Chander, Johanna Dwyer, Michelle R J Hamlet, Francesca Macchiarini, Mercy PrabhuDas, Grace L Shen, Pushpa Tandon, Merriline M Vedamony
No abstract text is available yet for this article.
October 18, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28984040/equine-chlamydiosis-an-emerging-infectious-disease-requiring-a-one-health-surveillance-approach
#5
K A Taylor, D Durrheim, J Heller, B O'Rourke, K Hope, T Merritt, P Freeman, C Chicken, J Carrick, J Branley, P Massey
Psittacosis is a rare but potentially fatal zoonosis caused by Chlamydia psittaci, an organism that is typically associated with bird contact. However C. psittaci is capable of infecting other non-avian hosts, such as horses, sheep, cattle and goats. Stud staff and veterinarians have significant exposure to parturient animals and reproductive materials in their routine work. To investigate the zoonotic potential associated with the emergence of C. psittaci as an abortifacient agent in horses, we established a programme of joint human and animal surveillance in a sentinel horse-breeding region in Australia...
October 5, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28953818/the-federation-of-student-islamic-societies-programme-to-challenge-mental-health-stigma-in-muslim-communities-in-england-the-fosis-birmingham-study
#6
Ahmed Hankir, Sajjaad Khalil, Qasim Wadood, Daanyaal Madarbukus, Habibah Arifah Yunus, Saleena Bibi, Frederick R Carrick, Rashid Zaman
BACKGROUND: 1 in 4 people experience mental health problems at some point during their lives and Muslims are no exception. Exacerbating the morbidity and mortality associated with mental health problems in Muslims is Islamophobia. Stigma and shame are major barriers to accessing and using mental health services and many Muslims with mental health problems do not receive the treatment they need. The Federation of Student Islamic Societies (FOSIS) United Kingdom branch organized a mental health conference to challenge the stigma attached to psychological problems in Muslims and to encourage care seeking in this group...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28953810/-a-labour-of-love-a-king-s-college-london-psychiatry-society-event-to-challenge-the-stigma-attached-to-mental-health-problems-in-post-natal-women
#7
Ahmed Hankir, Phillipa Brothwood, Bethany Crocker, Mao Fong Lim, Isabel Lever, Frederick Carrick, Rashid Zaman, Charlotte Wilson Jones
BACKGROUND: On the 9(th) October 2000, Dr Daksha Emson, a London based psychiatrist with bipolar affective disorder, tragically killed herself and her three-month-old baby daughter during a psychotic episode. An independent inquiry into Dr Emson's death concluded that mental health stigma in the National Health Service was a factor that contributed to her death. Despite the morbidity and mortality attributed to the stigma attached to post-natal mental health problems there are very few programmes that have been developed to challenge it...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28953808/a-king-s-college-london-undergraduate-psychiatry-society-event-to-challenge-the-stigma-attached-to-psychological-problems-in-healthcare-professionals-and-students
#8
Ahmed Hankir, Rashid Zaman, Mao Fong Lim, Isabel Lever, Phillipa Brothwood, Frederick R Carrick, Jamie Hacker Hughes, Charlotte Wilson Jones
BACKGROUND: There are higher levels of psychological distress in healthcare professionals and students compared to the general population. Yet, despite the availability of effective treatment, many in this group continue to suffer in silence. Fear of exposure to stigmatization has been identified to be a major barrier to accessing and using mental health services. King's College London Undergraduate Psychiatry Society (KCL PsychSoc) organized an event entitled, 'What does bipolar disorder even mean? Psychological distress: How can we challenge the stigma?'...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28953784/predictors-of-postpartum-depression-in-dubai-a-rapidly-growing-multicultural-society-in-the-united-arab-emirates
#9
Salwa M Alhammadi, Lien Abou Hashem, Zainah R Abusbeih, Fatima S Alzaabi, Salama N Alnuaimi, Ala F Jalabi, Satish C Nair, Frederick R Carrick, Mahera Abdulrahman
BACKGROUND: Postpartum depression (PPD) is a significant public health problem adversely affecting mothers, their newborns, and other members of the family. Although PPD is common and potentially dangerous, only a minority of the cases are identified in primary health care settings during routine care, and the majority of depressed mothers in the community lies unrecognized and therefore untreated. SUBJECTS AND METHODS: In this study, a total of 1500 mothers were approached randomly, 808 accepted to participate, and 504 were within the inclusion criteria (women who had a birth of a singleton full-term healthy infant, had an uncomplicated pregnancy, and were within their one week to six months postpartum)...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28953783/the-wounded-healer-film-a-london-college-of-communication-event-to-challenge-mental-health-stigma-through-the-power-of-motion-picture
#10
Ahmed Hankir, Rashid Zaman, Benjamin Geers, Gus Rosie, Grainne Breslin, Lilly Barr, Frederick R Carrick, Sal Anderson
BACKGROUND: There is a preponderance of mental health problems in students on a global scale which can have a considerable effect on their academic performance and a profound impact on their quality of life. Many universities offer free counselling services however despite this a recent study in the US revealed that up to 84% of students who screened positive for depression or anxiety did not receive any treatment. There are many obstacles that students with mental health problems encounter that prevents them from receiving care, foremost among these is stigma...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28953782/harnessing-the-power-of-film-to-combat-mental-health-stigma-a-university-college-london-psychiatry-society-event
#11
Samara Linton, Ahmed Hankir, Sal Anderson, Frederick R Carrick, Rashid Zaman
AIMS: To conduct a pilot study on a motion picture based, anti-stigma programme entitled, "The Wounded Healer film" to measure if it is associated with any changes in stigma variables in healthcare students and if it encouraged care seeking in this group. BACKGROUND: The 2008 Stigma Shout Survey of almost 4000 people using mental health services and carers revealed that healthcare professionals are a common source of stigma reported by people with mental illness...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28953778/the-federation-of-student-islamic-societies-programme-to-challenge-mental-health-stigma-in-muslim-communities-in-ireland-the-fosis-dublin-study
#12
Ahmed Hankir, Hannah Pendegast, Frederick R Carrick, Rashid Zaman
BACKGROUND: Mental health problems are common in Muslim communities however due to fear of exposure to stigmatization many people in this group continue to suffer in silence despite the availability of effective treatment. The Federation of Student Islamic Societies (FOSIS) organized the first ever Muslim mental health conference in Ireland to challenge the stigma attached to mental health problems in Muslims and to encourage care seeking in this group. As far as the authors are aware there are no intervention studies on mental health stigma in Muslim communities reported in the literature...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28953763/the-performing-arts-and-psychological-well-being
#13
Ahmed Hankir, Bruce Kirkcaldy, Frederick R Carrick, Asad Sadiq, Rashid Zaman
Although psychotropic drugs have been hailed as, 'One of the success stories of modern psychiatry' the prescribing of these medicines has not been without commotion, concern and controversy. Moreover, the President of the World Psychiatry Association Professor Dinesh Bhugra and colleagues, after conducting a recent large-scale study (n=25,522) on psychiatric morbidity in the UK, collectively issued the clarion call that, 'The mental health of the nation was unlikely to be improved by treatment with psychotropic medication alone'...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28953759/part-ii-muslims-perceptions-of-british-cobat-troops
#14
Ahmed Hankir, Frederick R Carrick, Rashid Zaman, Jamie Hacker Hughes
BACKGROUND: On the 22(nd) May 2017, suicide bomber Salman Abedi detonated an improvised explosive device (IED) in the Manchester Arena killing 22 people and injuring 116 others. Following the 'massacre in Manchester', the leader of the Labour Party, Jeremy Corbyn, linked UK foreign policy with terrorism on British soil. Controversial and contentious though Corbyn's claims may be, the terrorists themselves have also reported that what motivates them to carry out their abominable atrocities are British military operations in Muslim majority countries...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28953758/part-i-muslims-social-inclusion-and-the-west-exploring-challenges-faced-by-stigmatized-groups
#15
Ahmed Hankir, Frederick R Carrick, Rashid Zaman
The rise of radicalisation, the 'demonization' of Muslims in the media and the immigration crisis in Europe have all contributed and colluded to heightened levels of Islamophobia in the West. The stigmatisation of Muslims can and has resulted in negative outcomes in this group such as elevated levels of psychological distress and an increase in hate crime and terrorist attacks perpetrated against Muslims from members of the far right. There are 1.6 billion Muslims on the planet and Islam is the fastest growing religion in the world...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28930958/perioperative-use-of-nonsteroidal-anti-inflammatory-drugs-and-the-risk-of-anastomotic-failure-in-emergency-general-surgery
#16
Nadeem N Haddad, Brandon R Bruns, Toby M Enniss, David Turay, Joseph V Sakran, Alisan Fathalizadeh, Kristen Arnold, Jason S Murry, Matthew M Carrick, Matthew C Hernandez, Margaret H Lauerman, Asad J Choudhry, David S Morris, Jose J Diaz, Herb A Phelan, Martin D Zielinski
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used analgesic and anti-inflammatory adjuncts. Nonsteroidal anti-inflammatory drug administration may potentially increase the risk of postoperative gastrointestinal anastomotic failure (AF). We aim to determine if perioperative NSAID utilization influences gastrointestinal AF in emergency general surgery (EGS) patients undergoing gastrointestinal resection and anastomosis. METHODS: Post hoc analysis of a multi-institutional prospectively collected database was performed...
October 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28918704/professionalism-among-multicultural-medical-students-in-the-united-arab-emirates
#17
Mahera Abdulrahman, Shahd Alsalehi, Zahra S M Husain, Satish C Nair, Frederick Robert Carrick
BACKGROUND: Moral competencies and ethical practices of medical professionals are among the desired outcomes of academic training. Unfortunately, academic dishonesty and misconduct are reported from medical colleges across the world. This study investigates the level of academic dishonesty/misconduct among multicultural medical students. OBJECTIVE: The aim of this study is to investigate the level of academic dishonesty/misconduct among multicultural medical students...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28915394/overcoming-the-warburg-effect-is-it-the-key-to-survival-in-sepsis
#18
REVIEW
David Bar-Or, Matthew Carrick, Allen Tanner, Mark J Lieser, Leonard T Rael, Edward Brody
Sepsis is a leading cause of mortality in the U.S. and Europe. Sepsis and septic shock are the results of severe metabolic abnormalities following infection. Aerobic glycolysis (the Warburg Effect) is as much a hallmark of sepsis as it is of cancer. Warburg observed that cancer cells generated energy through glycolysis (generation of ATP through degradation of glucose, usually associated with anaerobic conditions) rather than through oxidative phosphorylation (generation of ATP through the mitochondrial inner membrane via the tricarboxylic acid cycle, usually associated with aerobic conditions)...
September 8, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28878731/head-eye-vestibular-motion-therapy-affects-the-mental-and-physical-health-of-severe-chronic-postconcussion-patients
#19
Frederick Robert Carrick, Joseph F Clark, Guido Pagnacco, Matthew M Antonucci, Ahmed Hankir, Rashid Zaman, Elena Oggero
CONTEXT: Approximately 1.8-3.6 million annual traumatic brain injuries occur in the United States. An evidence-based treatment for concussions that is reliable and effective has not been available. OBJECTIVE: The objective of this study is to test whether head-eye vestibular motion (HEVM) therapy is associated with decreased symptoms and increased function in postconcussive syndrome (PCS) patients that have been severely impaired for greater than 6 months after a mild traumatic brain injury...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28806309/single-center-experience-of-over-a-hundred-implantations-of-a-transcutaneous-bone-conduction-device
#20
Panagiotis A Dimitriadis, Daniel Hind, Kay Wright, Vicki Proctor, Larissa Greenwood, Suzanne Carrick, Jaydip Ray
OBJECTIVE: To assess outcomes with a novel passive transcutaneous bone conduction device (t-BCD). STUDY DESIGN: Prospective data collection and patient review. SETTING: Tertiary referral center. PATIENTS: Patients who underwent implantation with the t-BCD between November 2013 and September 2016. INTERVENTION: Implantation of BAHA Attract. MAIN OUTCOME MEASURES: Surgical outcome, patient reported outcomes including the "Glasgow Benefit Inventory" and the "Client Oriented Scale of Improvement" for adults and the "Speech, Spatial and Qualities of Hearing scale" (SSQ-12) for children...
October 2017: Otology & Neurotology
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