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https://www.readbyqxmd.com/read/29350344/the-relationship-between-exercise-dose-and-health-related-quality-of-life-with-a-phase-iii-cardiac-rehabilitation-program
#1
Borja Del Pozo-Cruz, Graeme Carrick-Ranson, Stacey Reading, Paul Nolan, Lance C Dalleck
PURPOSE: To quantify the relationship between the change in exercise dose and health-related quality of life (HRQoL) in a cohort of patients participating in a community-based phase-3 cardiac rehabilitation (CR) program. METHODS: A retrospective, pre-experimental (no control group) design of 58 participants that completed a phase-3, 12-week exercise-based CR program was used to test the current hypothesis. Self-reported HRQoL (36-Item Short Form Health Survey Version 2, SF-36v2) was assessed prior and after completing the CR program...
January 19, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29341793/platelet-transfusion-does-not-improve-outcomes-in-patients-with-brain-injury-on-antiplatelet-therapy
#2
Jeremy L Holzmacher, Cassandra Reynolds, Mayur Patel, Patrick Maluso, Seth Holland, Nathaniel Gamsky, Henry Moore, Elizabeth Acquista, Matthew Carrick, Richard Amdur, Heather Hancock, Michael Metzler, Julie Dunn, Babak Sarani
INTRODUCTION: Platelet dysfunction following traumatic brain injury (TBI) is associated with worse outcomes. The efficacy of platelet transfusion to reverse antiplatelet medication (APM) remains unknown. Thrombelastography platelet mapping (TEG-PM) assesses platelet function. We hypothesize that platelet transfusion can reverse the effects of APM but does not improve outcomes following TBI. METHODS: An observational study at six US trauma centres was performed. Adult patients on APM with CT evident TBI after blunt injury were enrolled...
January 17, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29298242/contemporary-management-of-high-grade-renal-trauma-results-from-the-american-association-for-the-surgery-of-trauma-aast-genitourinary-trauma-study
#3
Sorena Keihani, Yizhe Xu, Angela P Presson, James M Hotaling, Raminder Nirula, Joshua Piotrowski, Christopher M Dodgion, Cullen M Black, Kaushik Mukherjee, Bradley J Morris, Sarah Majercik, Brian P Smith, Ian Schwartz, Sean P Elliott, Erik S DeSoucy, Scott Zakaluzny, Peter B Thomsen, Bradley A Erickson, Nima Baradaran, Benjamin N Breyer, Brandi Miller, Richard A Santucci, Matthew M Carrick, Timothy Hewitt, Frank N Burks, Jurek F Kocik, Reza Askari, Jeremy B Myers
BACKGROUND: The rarity of renal trauma limits its study and the strength of evidence-based guidelines. Although management of renal injuries has shifted towards a non-operative approach, nephrectomy remains the most common intervention for high-grade renal trauma (HGRT). We aimed to describe the contemporary management of HGRT in the United States and also evaluate clinical factors associated with nephrectomy after HGRT. METHODS: From 2014 to 2017, data on HGRT (American Association for the Surgery of Trauma [AAST] grades III-V) were collected from 14 participating Level-1 trauma centers...
January 2, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29251711/beta-blockers-in-critically-ill-patients-with-traumatic-brain-injury-results-from-a-multi-center-prospective-observational-aast-study
#4
Eric J Ley, Samuel D Leonard, Galinos Barmparas, Navpreet K Dhillon, Kenji Inaba, Ali Salim, Karen R OʼBosky, Danielle Tatum, Hooman Azmi, Chad G Ball, Paul T Engels, Julie A Dunn, Matthew M Carrick, Jonathan P Meizoso, Sarah Lombardo, Bryan A Cotton, Thomas J Schroeppel, Sandro Rizoli, David S J Chang, Luis Alejandro de León, Joao Rezende-Neto, Tomas Jacome, Jimmy Xiao, Gina Mallory, Krishnamurti Rao, Lars Widdel, Samuel Godin, Angela Coates, Leo Andrew Benedict, Raminder Nirula, Sanjeev Kaul, Tong Li
BACKGROUND: Beta blockers, a class of medications that inhibit endogenous catecholamines interaction with beta adrenergic receptors, are often administered to patients hospitalized after traumatic brain injury (TBI). We tested the hypothesis that beta blocker use after TBI is associated with lower mortality, and secondarily compared propranolol to other beta blockers. METHODS: The AAST Clinical Trial Group conducted a multi-institutional, prospective, observational trial in which adult TBI patients who required ICU admission were compared based on beta blocker administration...
December 14, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29249435/the-effects-of-remote-ischaemic-preconditioning-on-coronary-artery-function-in-patients-with-stable-coronary-artery-disease
#5
D Corcoran, R Young, P Cialdella, P McCartney, A Bajrangee, B Hennigan, D Collison, D Carrick, A Shaukat, R Good, S Watkins, M McEntegart, J Watt, P Welsh, N Sattar, A McConnachie, K G Oldroyd, C Berry
BACKGROUND: Remote ischaemic preconditioning (RIPC) is a cardioprotective intervention invoking intermittent periods of ischaemia in a tissue or organ remote from the heart. The mechanisms of this effect are incompletely understood. We hypothesised that RIPC might enhance coronary vasodilatation by an endothelium-dependent mechanism. METHODS: We performed a prospective, randomised, sham-controlled, blinded clinical trial. Patients with stable coronary artery disease (CAD) undergoing elective invasive management were prospectively enrolled, and randomised to RIPC or sham (1:1) prior to angiography...
February 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29242240/persistence-of-infarct-zone-t2-hyperintensity-at-6-months-after-acute-st-segment-elevation-myocardial-infarction-incidence-pathophysiology-and-prognostic-implications
#6
Jaclyn Carberry, David Carrick, Caroline Haig, Nadeem Ahmed, Ify Mordi, Margaret McEntegart, Mark C Petrie, Hany Eteiba, Stuart Hood, Stuart Watkins, Mitchell Lindsay, Andrew Davie, Ahmed Mahrous, Ian Ford, Naveed Sattar, Paul Welsh, Aleksandra Radjenovic, Keith G Oldroyd, Colin Berry
BACKGROUND: The incidence and clinical significance of persistent T2 hyperintensity after acute ST-segment-elevation myocardial infarction (STEMI) is uncertain. METHODS AND RESULTS: Patients who sustained an acute STEMI were enrolled in a cohort study (BHF MR-MI: NCT02072850). Two hundred eighty-three STEMI patients (mean age, 59±12 years; 75% male) had cardiac magnetic resonance with T2 mapping performed at 2 days and 6 months post-STEMI. Persisting T2 hyperintensity was defined as infarct T2 >2 SDs from remote T2 at 6 months...
December 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29242043/sweep-tone-evoked-stimulus-frequency-otoacoustic-emissions-in-humans-development-of-a-noise-rejection-algorithm-and-normative-features
#7
Srikanta K Mishra, Carrick L Talmadge
In recent years, there has been a growing interest to measure stimulus frequency otoacoustic emissions (SFOAEs) using sweep tones. While there are several advantages of the sweep-tone technique, one of the major problems with sweep-tone methodologies is the lack of an objective analysis procedure that considers and rejects individual noisy recordings or noisy segments. A new efficient data-driven method for rejecting noisy segments in SFOAE analysis is proposed and the normative features of SFOAEs are characterized in fifty normal-hearing young adults...
November 20, 2017: Hearing Research
https://www.readbyqxmd.com/read/29240412/integration-of-on-column-chemical-reactions-in-protein-characterization-by-lc-ms-cross-path-reactive-chromatography
#8
Jake Pawlowski, Ian Carrick, Igor A Kaltashov
Profiling of complex proteins by means of mass spectrometry (MS) frequently requires that certain chemical modifications of their covalent structure (e.g., reduction of disulfide bonds) be carried out prior to the MS or MS/MS analysis. Traditionally, these chemical reactions take place in the off-line mode to allow the excess reagents (the majority of which interfere with the MS measurements and degrade the analytical signal) to be removed from the protein solution prior to MS measurements. In addition to a significant increase in the analysis time, chemical reactions may result in a partial or full loss of the protein if the modifications adversely affect its stability, e...
December 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29153575/persistent-iron-within-the-infarct-core%C3%A2-after-st-segment-elevation-myocardial-infarction-implications-for-left-ventricular-remodeling-and-health%C3%A2-outcomes
#9
Jaclyn Carberry, David Carrick, Caroline Haig, Nadeem Ahmed, Ify Mordi, Margaret McEntegart, Mark C Petrie, Hany Eteiba, Stuart Hood, Stuart Watkins, Mitchell Lindsay, Andrew Davie, Ahmed Mahrous, Ian Ford, Naveed Sattar, Paul Welsh, Aleksandra Radjenovic, Keith G Oldroyd, Colin Berry
OBJECTIVES: This study sought to determine the incidence and prognostic significance of persistent iron in patients post-ST-segment elevation myocardial infarction (STEMI). BACKGROUND: The clinical significance of persistent iron within the infarct core after STEMI complicated by acute myocardial hemorrhage is poorly understood. METHODS: Patients who sustained an acute STEMI were enrolled in a cohort study (BHF MR-MI [Detection and Significance of Heart Injury in ST Elevation Myocardial Infarction])...
November 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29127706/peptide-strand-length-controls-the-energetics-of-self-assembly-and-morphology-of-%C3%AE-sheet-fibrils
#10
Robert P W Davies, Binbin Liu, Steven Maude, Lisa M Carrick, Irina Nyrkova, Tom C McLeish, Sarah A Harris
Self-assembling peptides can be used as versatile, natural, and multifunctional building blocks to produce a variety of well-defined nanostructures, materials and devices for applications in medicine and nanotechnology. Here, we concentrate on the 1D self-assembly of de novo designed Px-2 peptide β-strands into anti-parallel β-sheet tapes and higher order aggregates. We study six members of the Px-2 family, ranging from 3 amino acids (aa) to 13 aa in length, using a range of complementary experimental techniques, computer simulation and theoretical statistical mechanics...
November 11, 2017: Biopolymers
https://www.readbyqxmd.com/read/29077636/effects-of-sedentary-aging-and-lifelong-exercise-on-left-ventricular-systolic-function
#11
Erin J Howden, Graeme Carrick-Ranson, Satyam Sarma, Michinari Hieda, Naoki Fujimoto, Benjamin D Levine
PURPOSE: The current study examined whether age-related changes in left ventricular (LV) longitudinal systolic function is an adaptation to a more sedentary lifestyle and can be preserved by lifelong exercise training. METHODS: A cross-sectional examination of 18 sedentary young (37±6 years), 29 sedentary seniors (71±5 years, 0-3 exercise sessions/wk), and 26 seniors (68±5 years) who had performed a committed level (4-7 exercise sessions/wk) of lifelong (>25 years) exercise...
October 26, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29051544/estimating-prognosis-in-patients-with-acute-myocardial-infarction-using-personalized-computational-heart-models
#12
Hao Gao, Kenneth Mangion, David Carrick, Dirk Husmeier, Xiaoyu Luo, Colin Berry
Biomechanical computational models have potential prognostic utility in patients after an acute ST-segment-elevation myocardial infarction (STEMI). In a proof-of-concept study, we defined two groups (1) an acute STEMI group (n = 6, 83% male, age 54 ± 12 years) complicated by left ventricular (LV) systolic dysfunction; (2) an age- and sex- matched hyper-control group (n = 6, 83% male, age 46 ± 14 years), no prior history of cardiovascular disease and normal systolic blood pressure (SBP < 130 mmHg)...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29044245/biomarkers-of-chronic-inflammation-in-disease-development-and-prevention-challenges-and-opportunities
#13
Christina H Liu, Natalie D Abrams, Danielle M Carrick, Preethi Chander, Johanna Dwyer, Michelle R J Hamlet, Francesca Macchiarini, Mercy PrabhuDas, Grace L Shen, Pushpa Tandon, Merriline M Vedamony
No abstract text is available yet for this article.
October 18, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28984040/equine-chlamydiosis-an-emerging-infectious-disease-requiring-a-one-health-surveillance-approach
#14
K A Taylor, D Durrheim, J Heller, B O'Rourke, K Hope, T Merritt, P Freeman, C Chicken, J Carrick, J Branley, P Massey
Psittacosis is a rare but potentially fatal zoonosis caused by Chlamydia psittaci, an organism that is typically associated with bird contact. However C. psittaci is capable of infecting other non-avian hosts, such as horses, sheep, cattle and goats. Stud staff and veterinarians have significant exposure to parturient animals and reproductive materials in their routine work. To investigate the zoonotic potential associated with the emergence of C. psittaci as an abortifacient agent in horses, we established a programme of joint human and animal surveillance in a sentinel horse-breeding region in Australia...
October 5, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28953818/the-federation-of-student-islamic-societies-programme-to-challenge-mental-health-stigma-in-muslim-communities-in-england-the-fosis-birmingham-study
#15
Ahmed Hankir, Sajjaad Khalil, Qasim Wadood, Daanyaal Madarbukus, Habibah Arifah Yunus, Saleena Bibi, Frederick R Carrick, Rashid Zaman
BACKGROUND: 1 in 4 people experience mental health problems at some point during their lives and Muslims are no exception. Exacerbating the morbidity and mortality associated with mental health problems in Muslims is Islamophobia. Stigma and shame are major barriers to accessing and using mental health services and many Muslims with mental health problems do not receive the treatment they need. The Federation of Student Islamic Societies (FOSIS) United Kingdom branch organized a mental health conference to challenge the stigma attached to psychological problems in Muslims and to encourage care seeking in this group...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28953810/-a-labour-of-love-a-king-s-college-london-psychiatry-society-event-to-challenge-the-stigma-attached-to-mental-health-problems-in-post-natal-women
#16
Ahmed Hankir, Phillipa Brothwood, Bethany Crocker, Mao Fong Lim, Isabel Lever, Frederick Carrick, Rashid Zaman, Charlotte Wilson Jones
BACKGROUND: On the 9th October 2000, Dr Daksha Emson, a London based psychiatrist with bipolar affective disorder, tragically killed herself and her three-month-old baby daughter during a psychotic episode. An independent inquiry into Dr Emson's death concluded that mental health stigma in the National Health Service was a factor that contributed to her death. Despite the morbidity and mortality attributed to the stigma attached to post-natal mental health problems there are very few programmes that have been developed to challenge it...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28953808/a-king-s-college-london-undergraduate-psychiatry-society-event-to-challenge-the-stigma-attached-to-psychological-problems-in-healthcare-professionals-and-students
#17
Ahmed Hankir, Rashid Zaman, Mao Fong Lim, Isabel Lever, Phillipa Brothwood, Frederick R Carrick, Jamie Hacker Hughes, Charlotte Wilson Jones
BACKGROUND: There are higher levels of psychological distress in healthcare professionals and students compared to the general population. Yet, despite the availability of effective treatment, many in this group continue to suffer in silence. Fear of exposure to stigmatization has been identified to be a major barrier to accessing and using mental health services. King's College London Undergraduate Psychiatry Society (KCL PsychSoc) organized an event entitled, 'What does bipolar disorder even mean? Psychological distress: How can we challenge the stigma?'...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28953784/predictors-of-postpartum-depression-in-dubai-a-rapidly-growing-multicultural-society-in-the-united-arab-emirates
#18
Salwa M Alhammadi, Lien Abou Hashem, Zainah R Abusbeih, Fatima S Alzaabi, Salama N Alnuaimi, Ala F Jalabi, Satish C Nair, Frederick R Carrick, Mahera Abdulrahman
BACKGROUND: Postpartum depression (PPD) is a significant public health problem adversely affecting mothers, their newborns, and other members of the family. Although PPD is common and potentially dangerous, only a minority of the cases are identified in primary health care settings during routine care, and the majority of depressed mothers in the community lies unrecognized and therefore untreated. SUBJECTS AND METHODS: In this study, a total of 1500 mothers were approached randomly, 808 accepted to participate, and 504 were within the inclusion criteria (women who had a birth of a singleton full-term healthy infant, had an uncomplicated pregnancy, and were within their one week to six months postpartum)...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28953783/the-wounded-healer-film-a-london-college-of-communication-event-to-challenge-mental-health-stigma-through-the-power-of-motion-picture
#19
Ahmed Hankir, Rashid Zaman, Benjamin Geers, Gus Rosie, Grainne Breslin, Lilly Barr, Frederick R Carrick, Sal Anderson
BACKGROUND: There is a preponderance of mental health problems in students on a global scale which can have a considerable effect on their academic performance and a profound impact on their quality of life. Many universities offer free counselling services however despite this a recent study in the US revealed that up to 84% of students who screened positive for depression or anxiety did not receive any treatment. There are many obstacles that students with mental health problems encounter that prevents them from receiving care, foremost among these is stigma...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28953782/harnessing-the-power-of-film-to-combat-mental-health-stigma-a-university-college-london-psychiatry-society-event
#20
Samara Linton, Ahmed Hankir, Sal Anderson, Frederick R Carrick, Rashid Zaman
AIMS: To conduct a pilot study on a motion picture based, anti-stigma programme entitled, "The Wounded Healer film" to measure if it is associated with any changes in stigma variables in healthcare students and if it encouraged care seeking in this group. BACKGROUND: The 2008 Stigma Shout Survey of almost 4000 people using mental health services and carers revealed that healthcare professionals are a common source of stigma reported by people with mental illness...
September 2017: Psychiatria Danubina
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