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https://www.readbyqxmd.com/read/28627628/phosphorothioate%C3%A2-modified-antisense-oligonucleotides-against-human-telomerase-reverse-transcriptase-sensitize-cancer-cells-to-radiotherapy
#1
Fei Cao, Xiaoping Ju, Di Chen, Lingong Jiang, Xiaofei Zhu, Shuiwang Qing, Fang Fang, Yuxin Shen, Zhen Jia, Huojun Zhang
Emergence of resistance, unavoidable systemic toxicity and unsatisfactory efficacy arethe main obstacles for traditional cancer therapy. Combination with phosphorothioate modified antisense oligonucleotides (PS‑ASODN) against human telomerase reverse transcriptase (hTERT) may enhance the therapeutic effect of irradiation. However, the effect of PS‑ASODN against hTERT on the anti‑tumor effects of irradiation in liver cancer remain unclear. In the current study, Walker 256 cells were transfected with hTERT PS‑ASODN...
June 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28621612/association-of-anril-gene-polymorphisms-with-prostate-cancer-and-benign-prostatic-hyperplasia-in-an-iranian-population
#2
Mohammad Taheri, Farkhondeh Pouresmaeili, Mir Davood Omrani, Mohsen Habibi, Shaghayegh Sarrafzadeh, Rezvan Noroozi, Azadeh Rakhshan, Arezou Sayad, Soudeh Ghafouri-Fard
AIM: Prostate cancer and benign prostate hyperplasia (BPH) are heterogeneous disorders with high prevalence among men. The antisense noncoding RNA in the INK4 locus codes for a long noncoding RNA whose participation in cancer has been elucidated. METHOD: We analyzed rs1333045, rs4977574, rs1333048 and rs10757278 genotypes from this locus in 125 prostate cancer patients, 125 BPH patients as well as 220 normal age-matched subjects by means of tetra-primer amplification refractory mutation system PCR method...
May 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28620146/mitochondrial-asncmtrna-1-and-asncmtrna-2-as-potent-targets-to-inhibit-tumor-growth-and-metastasis-in-the-renca-murine-renal-adenocarcinoma-model
#3
Vincenzo Borgna, Jaime Villegas, Verónica A Burzio, Sebastián Belmar, Mariela Araya, Emanuel Jeldes, Lorena Lobos-González, Verónica Silva, Claudio Villota, Luciana Oliveira-Cruz, Constanza Lopez, Teresa Socias, Octavio Castillo, Luis O Burzio
Knockdown of antisense noncoding mitochondrial RNAs (ASncmtRNAs) induces apoptosis in several human and mouse tumor cell lines, but not normal cells, suggesting this approach for a selective therapy against different types of cancer. Here we show that in vitro knockdown of murine ASncmtRNAs induces apoptotic death of mouse renal adenocarcinoma RenCa cells, but not normal murine kidney epithelial cells. In a syngeneic subcutaneous RenCa model, treatment delayed and even reversed tumor growth. Since the subcutaneous model does not reflect the natural microenviroment of renal cancer, we used an orthotopic model of RenCa cells inoculated under the renal capsule...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28615361/targeting-kras-dependent-tumors-with-azd4785-a-high-affinity-therapeutic-antisense-oligonucleotide-inhibitor-of-kras
#4
Sarah J Ross, Alexey S Revenko, Lyndsey L Hanson, Rebecca Ellston, Anna Staniszewska, Nicky Whalley, Sanjay K Pandey, Mitchell Revill, Claire Rooney, Linda K Buckett, Stephanie K Klein, Kevin Hudson, Brett P Monia, Michael Zinda, David C Blakey, Paul D Lyne, A Robert Macleod
Activating mutations in KRAS underlie the pathogenesis of up to 20% of human tumors, and KRAS is one of the most frequently mutated genes in cancer. Developing therapeutics to block KRAS activity has proven difficult, and no direct inhibitor of KRAS function has entered clinical trials. We describe the preclinical evaluation of AZD4785, a high-affinity constrained ethyl-containing therapeutic antisense oligonucleotide (ASO) targeting KRAS mRNA. AZD4785 potently and selectively depleted cellular KRAS mRNA and protein, resulting in inhibition of downstream effector pathways and antiproliferative effects selectively in KRAS mutant cells...
June 14, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28612367/association-between-genetic-variants-in-the-promoter-region-of-a-novel-antisense-long-noncoding-rna-rp11-392p7-6-and-colorectal-cancer-risk
#5
Mingjuan Jin, Simeng Gu, Ding Ye, Yingjun Li, Fangyuan Jing, Qilong Li, Kun Chen
There is a widespread occurrence of antisense transcripts' regulation on cancer-related genes in cancer biology. RP11-392P7.6 is antisense to the coding region of cancer-related gene GPRC5D, which has been found recently. The aim of this study was to investigate the associations of tagSNPs in the promoter region of RP11-392P7.6 with the risk of colorectal cancer. We conducted a two-stage case-control study, with a discovery set (320 cases and 319 controls) and a validation set (501 cases and 538 controls). Four tagSNPs (rs1531970, rs1642199, rs4763903, and rs10845671) were selected based on 1000 Genomes Project data and genotyped by using the Sequenom MassARRAY genotyping platform...
June 14, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/28600629/knockdown-of-long-non-coding-rna-kcnq1ot1-depressed-chemoresistance-to-paclitaxel-in-lung-adenocarcinoma
#6
Kaiming Ren, Ran Xu, Jingshan Huang, Jungang Zhao, Wenjun Shi
Lung cancer, with the highest morbidity and second highest death rates, is one of the most common cancers in both males and females worldwide. Lung adenocarcinoma (LAD) is the main lung cancer class. KCNQ1 Opposite Strand/Antisense Transcript 1 (KCNQ1OT1) gene is an lncRNA which had been reported high-expression in colorectal cancer. In this study, the expression of KCNQ1OT1 was confirmed to be highly expressed in LAD tissues and cells contrast to control tissues and cells, and high KCNQ1OT1 expression correlated to malignant behaviors of LAD, including big tumor size, poor differentiation, positive lymphatic metastasis and high TNM stages...
June 9, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28600545/hotair-rs7958904-polymorphism-is-associated-with-increased-cervical-cancer-risk-in-a-chinese-population
#7
Hua Jin, Xiaoyun Lu, Jing Ni, Jinfang Sun, Bin Gu, Bo Ding, Haixia Zhu, Chao Ma, Mengjing Cui, Yuling Xu, Zhengdong Zhang, Martin Lercher, Jian Chen, Na Gao, Shizhi Wang
Previously, we have identified single nucleotide polymorphisms (SNPs) rs7958904 and rs4759314 in long non-coding RNA HOX transcript antisense RNA (HOTAIR) were significantly associated with risk of colorectal and gastric cancer, respectively. Here, we aimed to investigate the association between HOTAIR SNPs and cervical cancer (CC) susceptibility. A total of 1209 cases and 1348 controls were enrolled for association study and genotyped with TaqMan allelic discrimination method. The Cancer Genome Atlas (TCGA) database was utilized for in vivo analysis of allele-specific HOTAIR expression...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28599289/enhanced-antiproliferative-activity-of-antibody-functionalized-polymeric-nanoparticles-for-targeted-delivery-of-anti-mir-21-to-her2-positive-gastric-cancer
#8
Feng-Lei Wu, Jian Zhang, Wei Li, Bao-Xiang Bian, Yi-Dong Hong, Zi-Yan Song, Hui-Yu Wang, Fang-Bo Cui, Ru-Tian Li, Qin Liu, Xiao-Dong Jiang, Xiao-Min Li, Jun-Nian Zheng
MiR-21 is an oncogenic miR frequently elevated in gastric cancer. Overexpression of miR-21 decreases the sensitivity of gastric cancer cells to trastuzumab, which is a humanized monoclonal antibody targeting human epidermal growth factor receptor 2. However, optimization of miRNA or its anti-miRNA oligonucleotides (AMOs) for delivery is a challenge. Receptor-mediated endocytosis plays a crucial role in the delivery of biotherapeutics including AMOs. This study is a continuation of our earlier findings involving poly(ε-caprolactone) (PCL)-poly (ethylene glycol) (PEG) nanoparticles (PEG-PCL NPs), which were coated with trastuzumab to target gastric cancer cells with HER2 receptor over-expression using anti-miRNA-21 antisense oligonucleotides (AMO-21)...
May 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28594398/loss-of-the-novel-mitochondrial-protein-fam210b-promotes-metastasis-via-pdk4-dependent-metabolic-reprogramming
#9
Shujuan Sun, Jia Liu, Meisong Zhao, Yingyan Han, Pingbo Chen, Qingqing Mo, Beibei Wang, Gang Chen, Yong Fang, Yuan Tian, Jianfeng Zhou, Ding Ma, Qinglei Gao, Peng Wu
Recent advances in tumor metabolism have revealed that metabolic reprogramming could dramatically promote caner metastasis. However, the relation and mechanism between metastasis and metabolic reprogramming are not thoroughly explored. Cell proliferation, colony formation, and invasion analysis were performed to evaluate the role of FAM210B in human cancer cells. Human ovarian cancer xenograft model was used to determine the effects of inhibiting FAM210B by shRNA on tumor metastasis. Microarray analysis was used to determine the target genes of FAM210B...
June 8, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28591050/clinicopathological-and-prognostic-significance-of-homeobox-transcript-antisense-rna-expression-in-various-cancers-a-meta-analysis
#10
Sai-Nan Min, Tai Wei, Xiang-Ting Wang, Li-Ling Wu, Guang-Yan Yu
BACKGROUND: Increased expression of the homeobox (HOX) transcript antisense RNA (HOTAIR) has been reported in multiple types of malignancies and enhances the proliferation and migration of cancer cells. However, the association between HOTAIR expression and tumor progression and prognosis remains controversial. We performed a meta-analysis to clarify the association between the expression of HOTAIR and the clinicopathological features and prognosis in different cancers. METHODS: A systematic search of the PubMed, Web of Science, EMBASE, and Ovid databases was conducted, up to September 2016, for eligible studies involving HOTAIR expression and malignancies...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28580310/anril-genetic-variants-in-iranian-breast-cancer-patients
#11
Hamid Reza Khorshidi, Mohammad Taheri, Rezvan Noroozi, Shaghayegh Sarrafzadeh, Arezou Sayad, Soudeh Ghafouri-Fard
OBJECTIVE: The genetic variants of the long non-coding RNA ANRIL (an antisense noncoding RNA in the INK4 locus) as well as its expression have been shown to be associated with several human diseases including cancers. The aim of this study was to examine the association of ANRIL variants with breast cancer susceptibility in Iranian patients. MATERIALS AND METHODS: In this case-control study, we genotyped rs1333045, rs4977574, rs1333048 and rs10757278 single nucleotide polymorphisms (SNPs) in 122 breast can- cer patients as well as in 200 normal age-matched subjects by tetra-primer amplification refractory mutation system polymerase chain reaction (T-ARMS-PCR)...
2017: Cell Journal
https://www.readbyqxmd.com/read/28577281/acquired-tamoxifen-resistance-in-mcf-7-breast-cancer-cells-requires-hyperactivation-of-eif4f-mediated-translation
#12
Dedra H Fagan, Lynsey M Fettig, Svetlana Avdulov, Heather Beckwith, Mark S Peterson, Yen-Yi Ho, Fan Wang, Vitaly A Polunovsky, Douglas Yee
While selective estrogen receptor modulators, such as tamoxifen, have contributed to increased survival in patients with hormone receptor-positive breast cancer, the development of resistance to these therapies has led to the need to investigate other targetable pathways involved in oncogenic signaling. Approval of the mTOR inhibitor everolimus in the therapy of secondary endocrine resistance demonstrates the validity of this approach. Importantly, mTOR activation regulates eukaryotic messenger RNA translation...
June 2, 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/28565838/hotair-is-a-promising-novel-biomarker-in-patients-with-thyroid-cancer
#13
Yifei Zhang, Sui Yu, Lixin Jiang, Xixun Wang, Xiaojing Song
Thyroid cancer (TC) is the most common endocrine malignancy. Lack of effective early diagnostic tools is one of the clinical obstacles for TC treatment. Thus, enhanced comprehension of the molecular changes in TC tumorigenesis is urgently needed to develop novel strategies for the diagnosis and treatment of TC. Long non-coding RNAs (lncRNAs) manage fundamental biochemical and cellular processes in tumorigenesis and development. One of the best-described lncRNAs, HOX transcript antisense RNA (HOTAIR), functions as a regulatory molecule in a wide variety of biological processes, and represses gene expression through recruitment of the chromatin modifying complex...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28561791/epigenetic-control-of-human-endogenous-retrovirus-expression-focus-on-regulation-of-long-terminal-repeats-ltrs
#14
REVIEW
Tara P Hurst, Gkikas Magiorkinis
Transposable elements, including endogenous retroviruses (ERVs), comprise almost 45% of the human genome. This could represent a significant pathogenic burden but it is becoming more evident that many of these elements have a positive contribution to make to normal human physiology. In particular, the contributions of human ERVs (HERVs) to gene regulation and the expression of noncoding RNAs has been revealed with the help of new and emerging genomic technologies. HERVs have the common provirus structure of coding open reading frames (ORFs) flanked by two long-terminal repeats (LTRs)...
May 31, 2017: Viruses
https://www.readbyqxmd.com/read/28553126/rna-binding-protein-hur-promotes-bladder-cancer-progression-by-competitively-binding-to-the-long-noncoding-hotair-with-mir-1
#15
Dapeng Yu, Chao Zhang, Junqing Gui
The elevated expressions of RNA-binding protein HuR and long noncoding HOX transcript antisense RNA (HOTAIR) are observed in numerous cancers. And HuR often exerts its promotive effects on tumorigenesis via binding to AU-rich elements in target transcripts and thus regulating the expression of target transcripts. However, the roles and related mechanisms of HuR/HOTAIR in bladder cancer progression have never been formally tested. Here, we found that the expression level of HuR was higher in clinical bladder cancer samples than in normal adjacent samples, mirroring that of HOTAIR, and their expression showed strong correlation...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28550682/long-noncoding-rna-anril-promotes-cervical-cancer-development-by-acting-as-a-sponge-of-mir-186
#16
Jun-Jun Zhang, Dan-Dan Wang, Chen-Xiang Du, Yan Wang
Cervical cancer is a common malignancy of female reproductive system. Long non-coding RNA (lncRNA) has been reported tomodulate tumor progression in multiple cancers. The lncRNA antisense non-coding RNA in the INK4 locus (ANRIL) has been testified as oncogenic molecular in series tumors, however, the function and underlying mechanism involved in cervical cancer oncogenesis is still unclear. In present study, RT-PCR showed that ANRIL expression was significantly up-regulated in cervical cancer tumors and cell lines...
May 22, 2017: Oncology Research
https://www.readbyqxmd.com/read/28545465/an-increase-in-long-non-coding-rna-pandar-is-associated-with-poor-prognosis-in-clear-cell-renal-cell-carcinoma
#17
Yi Xu, Yanyue Tong, Jianyong Zhu, Zhangming Lei, Lijun Wan, Xiuwen Zhu, Feng Ye, Liping Xie
BACKGROUND: Nearly 30% of clear cell renal cell carcinoma (ccRCC) patients present with metastasis at the time of diagnosis, and the prognosis for these patients is poor. Therefore, novel potential prognostic biomarkers and therapeutic targets for ccRCC could be helpful. Emerging evidence indicates that lncRNAs play important roles in cancer tumorigenesis and could be used as potential biomarkers or therapeutic targets. PANDAR (promoter of CDKN1A antisense DNA damage activated RNA) is a relatively novel lncRNA that plays an important role in the development of multiple cancers...
May 25, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28545023/long-non-coding-rna-hoxa-as2-promotes-proliferation-and-invasion-of-breast-cancer-by-acting-as-a-mir-520c-3p-sponge
#18
Yu Fang, Jingxuan Wang, Feng Wu, Ying Song, Shu Zhao, Qingyuan Zhang
The long non-coding RNA (lncRNA) HOXA cluster antisense RNA2 (HOXA-AS2) has recently been shown to be dysregulated and involved in the progression of several cancers. However, the biological role and clinical significance of HOXA-AS2 in the carcinogenesis of breast cancer are still unclear. In the present study, we found that HOXA-AS2 was up-regulated in human breast cancer tissues and cell lines and associated with clinicopathological characteristics. Silencing of HOXA-AS2 inhibited the progression of breast cancer cells in vitro and in vivo...
May 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28544466/simultaneous-imaging-of-endogenous-survivin-mrna-and-on-demand-drug-release-in-live-cells-by-using-a-mesoporous-silica-nanoquencher
#19
Peiyan Yuan, Xin Mao, Kok Chan Chong, Jiaqi Fu, Sijun Pan, Shuizhu Wu, Changmin Yu, Shao Q Yao
The design of multifunctional drug delivery systems capable of simultaneous target detection, imaging, and therapeutics in live mammalian cells is critical for biomedical research. In this study, by using mesoporous silica nanoparticles (MSNs) chemically modified with a small-molecule dark quencher, followed by sequential drug encapsulation, MSN capping with a dye-labeled antisense oligonucleotide, and bioorthogonal surface modification with cell-penetrating poly(disulfide)s, the authors have successfully developed the first mesoporous silica nanoquencher (qMSN), characterized by high drug-loading and endocytosis-independent cell uptake, which is able to quantitatively image endogenous survivin mRNA and release the loaded drug in a manner that depends on the survivin expression level in tumor cells...
May 24, 2017: Small
https://www.readbyqxmd.com/read/28534499/cis-perturbation-of-cancer-drivers-by-the-htlv-1-blv-proviruses-is-an-early-determinant-of-leukemogenesis
#20
Nicolas Rosewick, Keith Durkin, Maria Artesi, Ambroise Marçais, Vincent Hahaut, Philip Griebel, Natasa Arsic, Véronique Avettand-Fenoel, Arsène Burny, Carole Charlier, Olivier Hermine, Michel Georges, Anne Van den Broeke
Human T-cell leukaemia virus type-1 (HTLV-1) and bovine leukaemia virus (BLV) infect T- and B-lymphocytes, respectively, provoking a polyclonal expansion that will evolve into an aggressive monoclonal leukaemia in ∼5% of individuals following a protracted latency period. It is generally assumed that early oncogenic changes are largely dependent on virus-encoded products, especially TAX and HBZ, while progression to acute leukaemia/lymphoma involves somatic mutations, yet that both are independent of proviral integration site that has been found to be very variable between tumours...
May 23, 2017: Nature Communications
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