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https://www.readbyqxmd.com/read/28105233/mir-574-3p-acts-as-a-tumor-promoter-in-osteosarcoma-by-targeting-smad4-signaling-pathway
#1
Haidong Xu, Xiaozhou Liu, Juan Zhou, Xiaoyun Chen, Jianning Zhao
Human osteosarcoma is the most common primary bone malignancy sarcoma that affects primarily children and people <20 years old. In the present study, it was demonstrated that miR-574-3p was downregulated in human osteosarcoma U2OS, SAOS and MG63 cells lines as well as in osteosarcoma tissue compared with the normal tissues. Downregulation of miR-574-3p by antisense miR-574-3p, inhibited cell growth and induced cell apoptosis. Overexpression of miR-574-3p by transfection with miR-574-3p mimics promoted the growth of U2OS cells...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28088076/in%C3%A2-vivo-visualization-of-endogenous-mir-21-using-hyaluronic-acid-coated-graphene-oxide-for-targeted-cancer-therapy
#2
Do Won Hwang, Han Young Kim, Fangyuan Li, Ji Yong Park, Dohyun Kim, Jae Hyung Park, Hwa Seung Han, Jung Woo Byun, Yun-Sang Lee, Jae Min Jeong, Kookheon Char, Dong Soo Lee
Oncogene-targeted nucleic acid therapy has been spotlighted as a new paradigm for cancer therapeutics. However, in vivo delivery issues and uncertainty of therapeutic antisense drug reactions remain critical hurdles for a successful targeted cancer therapy. In this study, we developed a fluorescence-switchable theranostic nanoplatform using hyaluronic acid (HA)-conjugated graphene oxide (GO), which is capable of both sensing oncogenic miR-21 and inhibiting its tumorigenicity simultaneously. Cy3-labeled antisense miR-21 peptide nucleic acid (PNA) probes loaded onto HA-GO (HGP21) specifically targeted CD44-positive MBA-MB231 cells and showed fluorescence recovery by interacting with endogenous miR-21 in the cytoplasm of the MBA-MB231 cells...
December 31, 2016: Biomaterials
https://www.readbyqxmd.com/read/28070051/-prognostic-value-of-lncrna-hotair-expression-in-%C3%A2-patients-with-cancer-a-meta-analysis
#3
Wenna Xi, Wei Song
To systematically review the prognostic value regarding the expression of long non-coding RNA (lncRNA) Hox transcript antisense intergenic RNA (HOTAIR) in patients with cancer. 
 Methods: Databases including The Cochrane Library, EMBASE, MEDLINE, and PubMed were searched to collect English literature on the correlation between lncRNA HOTAIR expression and overall survival in tumors. The retrieval time was from inception to September 2015. After data were extracted, a Meta-analysis was performed using RevMan 5...
December 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28061540/metallothionein-2a-an-interactive-protein-linking-phosphorylated-fadd-to-nf-%C3%AE%C2%BAb-pathway-leads-to-colorectal-cancer-formation
#4
Faiz M M T Marikar, Guanghui Jin, Wang Sheng, Dingyuan Ma, Zichun Hua
BACKGROUND: The rapid increase in the incidence rate of colorectal cancer has led to the search and identification of biomarkers that can predict risk for and future behavior of this malignancy and management. To study the biological role of the phosphorylated Fas associated death domain (pFADD) gene in colorectal cancer, we performed a GAL4-based yeast two-hybrid screening of a human heart cDNA library. METHODS: A series of two yeast hybrid method was used to identification of protein-protein interaction...
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28052024/single-nucleotide-polymorphisms-in-znrd1-as1-increase-cancer-risk-in-an-asian-population
#5
Ping-Yu Wang, Jing-Hua Li, Yue-Mei Liu, Qing Lv, Ning Xie, Han-Han Zhang, Shu-Yang Xie
Single nucleotide polymorphisms (SNPs) in human zinc ribbon domain containing 1 antisense RNA 1 (ZNRD1-AS1) have been associated with cancer development. In this meta-analysis, we more precisely estimated the associations between three expression quantitative trait loci SNPs in ZNRD1-AS1 (rs3757328, rs6940552, and rs9261204) and cancer susceptibility. The data for three SNPs were extracted from eligible studies, which included 5,293 patients and 5,440 controls. Overall, no significant associations between SNPs in ZNRD1-AS1 (rs3757328, rs6940552, and rs9261204) and cancer risk were observed...
December 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/28051254/mir-214-negatively-regulates-proliferation-and-wnt-%C3%AE-catenin-signaling-in-breast-cancer
#6
S-J Yi, L-L Li, W-B Tu
OBJECTIVE: To analyze the function and mechanism of miR-214 in regulating breast cancer cell proliferation. MATERIALS AND METHODS: MiR-214 expression level was measured by quantitative reverse transcription Polymerase Chain Reaction (qRT-PCR). The protein level of β-catenin, PCNA and WNT targets (cyclin D1 and c-Myc) was evaluated by Western blot analysis. The effects of miR-214 on cell proliferation and cisplatin sensitivity were assessed by Cell Counting Kit-8 (CCK-8) assay and/or 5-bromo-2'-deoxyuridine (BrdU) assay...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28045030/small-rna-zippers-lock-mirna-molecules-and-block-mirna-function-in-mammalian-cells
#7
Lingyu Meng, Cuicui Liu, Jinhui Lü, Qian Zhao, Shengqiong Deng, Guangxue Wang, Jing Qiao, Chuyi Zhang, Lixiao Zhen, Ying Lu, Wenshu Li, Yuzhen Zhang, Richard G Pestell, Huiming Fan, Yi-Han Chen, Zhongmin Liu, Zuoren Yu
MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed 'small RNA zipper'. It is designed to connect miRNA molecules end to end, forming a DNA-RNA duplex through a complementary interaction with high affinity, high specificity and high stability. Two miRNAs, miR-221 and miR-17, are tested in human breast cancer cell lines, demonstrating the 70∼90% knockdown of miRNA levels by 30-50 nM small RNA zippers...
January 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/28042781/mir-21-an-oncogenic-target-mirna-for-cancer-therapy-molecular-mechanisms-and-recent-advancements-in-chemo-and-radio-resistance
#8
Sanaz Javanmardi, Mahmoud Reza Aghamaali, Samira Sadat Abolmaali, Samaneh Mohammadi, Ali Mohammad Tamaddon
In the past decade, miRNAs have been extensively attracted the scientist's attentions as tumor suppressors or oncogenes that have been implicated in tumor progression, metastasis and intrinsic resistance to various cancer therapies. microRNA-21 (miR-21) demonstrates a potential oncogenic function and target tumor inhibitor proteins in almost all types of cancer. miR-21 overexpression has been studied in terms of cell proliferation, migration, invasion, metastasis, and apoptosis regulation.Inhibition of miRNA expression using antisense technology by various nanovectors of different sizes, shapes and compositions has been evolved progressively to overcome the barriers confronted by miRNA delivery...
January 1, 2017: Current Gene Therapy
https://www.readbyqxmd.com/read/28036257/epigenetic-therapy-in-urologic-cancers-an-update-on-clinical-trials
#9
REVIEW
Inês Faleiro, Ricardo Leão, Alexandra Binnie, Ramon Andrade de Mello, Ana-Teresa Maia, Pedro Castelo-Branco
Epigenetic dysregulation is one of many factors that contribute to cancer development and progression. Numerous epigenetic alterations have been identified in urologic cancers including histone modifications, DNA methylation changes, and microRNA expression. Since these changes are reversible, efforts are being made to develop epigenetic drugs that restore the normal epigenetic patterns of cells, and many clinical trials are already underway to test their clinical potential. In this review we analyze multiple clinical trials (n=51) that test the efficacy of these drugs in patients with urologic cancers...
December 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/28032932/androgen-induced-lncrna-potef-as1-regulates-apoptosis-related-pathway-to-facilitate-cell-survival-in-prostate-cancer-cells
#10
Aya Misawa, Ken-Ichi Takayama, Tetsuya Fujimura, Yukio Homma, Yutaka Suzuki, Satoshi Inoue
Although long noncoding RNAs (lncRNA) have been associated with a variety of cancers, the interplay between lncRNAs and androgen receptor (AR) signaling in prostate cancer is still unclear. Here, we identified an androgen-dependent lncRNA, prostate, ovary, testis expressed protein family member-F antisense transcript-1 (POTEF-AS1), whose expression was regulated by AR in two androgen-dependent cells by using directional RNA-seq analysis. POTEF-AS1 promoted cell growth, repressed genes related to the toll-like receptor (TLR) signaling and apoptosis pathways and inhibited apoptosis in docetaxel-treated LNCaP cells...
December 29, 2016: Cancer Science
https://www.readbyqxmd.com/read/28029658/the-inhibition-of-45a-ncrna-expression-reduces-tumor-formation-affecting-tumor-nodules-compactness-and-metastatic-potential-in-neuroblastoma-cells
#11
Ilaria Penna, Arianna Gigoni, Delfina Costa, Serena Vella, Debora Russo, Alessandro Poggi, Federico Villa, Antonella Brizzolara, Claudio Canale, Andrea Mescola, Antonio Daga, Claudio Russo, Mario Nizzari, Tullio Florio, Paola Menichini, Aldo Pagano
We recently reported the in vitro over-expression of 45A, a RNA polymerase III-transcribed non-coding (nc)RNA, that perturbs the intracellular content of FE65L1 affecting cell proliferation rate, short-term response to genotoxic stress, substrate adhesion capacity and, ultimately, increasing the tumorigenic potential of human neuroblastoma cells. In this work, to deeply explore the mechanism by which 45A ncRNA contributes to cancer development, we targeted in vitro and in vivo 45A levels by the stable overexpression of antisense 45A RNA...
December 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/28026821/the-role-of-survivin-in-the-diagnosis-and-therapy-of-gynaecological-cancers
#12
Marta Denel-Bobrowska, Agnieszka Marczak
Survivin is a member of the family of apoptosis inhibitors. It regulates several essential cellular processes, i.e. it inhibits apoptosis and promotes cell proliferation, DNA repair and autophagy. Survivin is responsible for development of the cell's resistance to chemotherapy and radiotherapy. Overexpression of survivin generally correlates with poor prognosis. Its presence has been detected in most types of human tumours. Currently much attention is paid to the possibilities of using this protein as a diagnostic marker of cancer or a prognostic factor...
December 8, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28026123/liposomal-spherical-nucleic-acids-for-regulating-long-noncoding-rnas-in-the-nucleus
#13
Anthony J Sprangers, Liangliang Hao, Resham J Banga, Chad A Mirkin
Emerging evidence indicates that long noncoding RNAs (lncRNAs) are actively involved in a number of developmental and tumorigenic processes. Here, the authors describe the first successful use of spherical nucleic acids as an effective nanoparticle platform for regulating lncRNAs in cells; specifically, for the targeted knockdown of the nuclear-retained metastasis associated lung adenocarcinoma transcript 1 (Malat1), a key oncogenic lncRNA involved in metastasis of several cancers. Utilizing the liposomal spherical nucleic acid (LSNA) constructs, the authors first explored the delivery of antisense oligonucleotides to the nucleus...
December 27, 2016: Small
https://www.readbyqxmd.com/read/27992999/systematic-evaluation-of-biophysical-and-functional-characteristics-of-selenomethylene-locked-nucleic-acid-mediated-inhibition-of-mir-21
#14
Smita Nahar, Amrita Singh, Kunihiko Morihiro, Yoshihiro Moai, Tetsuya Kodama, Satoshi Obika, Souvik Maiti
miRNAs constitute an important layer of gene regulation mediated by sequence-specific targeting of mRNAs. Aberrant expression of miRNAs contributes to a host of pathological states. Promoting cancer, miR-21 is upregulated in variety of cancers and promotes tumor progresion by suppressing a network of tumor suppressor genes. Here we describe a novel class of bicyclic RNA analogues, selenomethylene-locked nucleic acid (SeLNA), that display high affinity, improved metabolic stability, and increased potency for miR-21 inhibition...
December 20, 2016: Biochemistry
https://www.readbyqxmd.com/read/27986121/intracellular-progesterone-receptor-mediates-the-increase-in-glioblastoma-growth-induced-by-progesterone-in-the-rat-brain
#15
Liliana Germán-Castelán, Joaquín Manjarrez-Marmolejo, Aliesha González-Arenas, Ignacio Camacho-Arroyo
BACKGROUND AND AIMS: Progesterone (P) is a steroid hormone involved in the development of several types of cancer including astrocytomas, the most common and malignant brain tumors. We undertook this study to investigate the effects of P on the growth and infiltration of a tumor caused by the xenotransplant of U87 cells derived from a human astrocytoma grade IV (glioblastoma) in the cerebral cortex of male rats and the participation of intracellular progesterone receptor (PR) on these effects...
August 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27982018/sio2-antisense-molecules-covered-by-nepetalactone-extracted-from-nepeta-gloeocephala-inhibits-ilk-phosphorylation-and-downstream-pkb-akt-signaling-in-hela-cells
#16
M Dehghany Ashkezary, F Aboee-Mehrizi, P Moradi
In this study, the anticancer property of SiO2@antisense molecules (SiO2@AMs) and SiO2@AM covered by nepetalactone (SiO2@AM/CN), extracted from Nepeta gloeocephala, was investigated. Here integrin-linked kinase (ILK) phosphorylation and protein kinase B/AKT (PKB/AKT) signaling was studied when HeLa cells were exposed to SiO2@AM and SiO2@AM/CN. First, N. gloeocephala was identified at the Iranian National Herbarium. Then, its essential oil (EO) was obtained by the hydrodistillation method. In the next step, 4aα,7α,7aα-nepetalactone was extracted from the EO, based on the spectroscopic data...
December 16, 2016: Cancer Gene Therapy
https://www.readbyqxmd.com/read/27979710/hotair-facilitates-hepatic-stellate-cells-activation-and-fibrogenesis-in-the-liver
#17
Er-Bao Bian, Yuan-Yuan Wang, Yang Yang, Bao-Ming Wu, Tao Xu, Xiao-Ming Meng, Cheng Huang, Lei Zhang, Xiong-Wen Lv, Zhi-Gang Xiong, Jun Li
Long non-coding RNAs (lncRNAs) are increasingly recognized as major players in regulating various biological processes. LncRNA HOX transcript antisense RNA (Hotair) has been extensively studied in cancer. However, the role of Hotair in liver fibrosis remains unknown. Here we observed that Hotair expression was significantly increased in CCl4-induced mouse liver fibrosis models, human fibrotic livers and activated hepatic stellate cells (HSCs) by TGF-β1 stimulation. Enforced expression of Hotair in LX-2 cells promoted cell proliferation and activation while inhibition of its expression had an opposite effect...
December 13, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27978767/clusterin-as-a-therapeutic-target
#18
Mark R Wilson, Amina Zoubeidi
Clusterin (CLU) is a stress-activated, ATP-independent molecular chaperone, normally secreted from cells, that is up-regulated in Alzheimer disease and in many cancers. It plays important roles in protein homeostasis/proteostasis, inhibition of cell death pathways, and modulation of pro-survival signalling and transcriptional networks. Changes in the CLU gene locus are highly associated with Alzheimer disease, and many therapy-resistant cancers over-express CLU. The extensive post-translational processing and heterogeneous oligomerization of CLU have so far prevented any definitive structure determination...
December 16, 2016: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/27977315/antibody-sirna-conjugates-drugging-the-undruggable-for-anti-leukemic-therapy
#19
Jogender Tushir-Singh
Generating effective RNAi-based therapies with the potential to achieve leukemia remission remains critical unmet need. Despite a growing number of leukemia clinical trials, tissue specific delivery of therapeutic siRNA is a major roadblock in translating its clinical potential. The most recent reports in the antibody-siRNA-conjugates (ARCs) field add new dimensions to leukemic therapy, where a covalently ligated therapeutic antisense-RNA with the potential to repress the oncogenic transcript is selectively delivered into the cancer cells...
December 23, 2016: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/27966450/upregulated-nnt-as1-a-long-noncoding-rna-contributes-to-proliferation-and-migration-of-colorectal-cancer-cells-in-vitro-and-in-vivo
#20
Qian Wang, Lei Yang, Xin Hu, Yuliang Jiang, Yizhang Hu, Zhe Liu, Jian Liu, Tao Wen, Yingmin Ma, Guangyu An, Guosheng Feng
The expression patterns of the long non-coding RNA Nicotinamide Nucleotide Transhydrogenase-antisense RNA1 (NNT-AS1) have not been investigated in the context of cancer. In this study, we aim to investigate the NNT-AS1 expression level in colorectal cancer (CRC) patients and its potential roles in tumor biology. We measured the expression of NNT-AS1 in 70 paired tumor tissues and adjacent normal tissues. NNT-AS1 was expressed higher in tumor tissues than that in adjacent noncancer tissues, and higher expression of NNT-AS1 was significantly correlated with lymph node metastasis (Yes vs...
December 9, 2016: Oncotarget
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